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17 pages, 2000 KiB  
Article
Can 3D Exoscopy-Assisted Surgery Replace the Traditional Endoscopy in Septoplasty? Analysis of Our Two-Year Experience
by Luciano Catalfamo, Alessandro Calvo, Samuele Cicchiello, Antonino La Fauci, Francesco Saverio De Ponte, Calogero Scozzaro and Danilo De Rinaldis
J. Clin. Med. 2025, 14(15), 5279; https://doi.org/10.3390/jcm14155279 - 25 Jul 2025
Viewed by 302
Abstract
Background/Objectives: Septoplasty is a commonly performed surgical procedure aimed at correcting nasal septal deviations, to improve nasal airflow and respiratory function. Traditional approaches to septal correction rely on either direct visualization or endoscopic guidance. Recently, a novel technology known as exoscopy has [...] Read more.
Background/Objectives: Septoplasty is a commonly performed surgical procedure aimed at correcting nasal septal deviations, to improve nasal airflow and respiratory function. Traditional approaches to septal correction rely on either direct visualization or endoscopic guidance. Recently, a novel technology known as exoscopy has been introduced into surgical practice. Exoscopy is an “advanced magnification system” that provides an enlarged, three-dimensional view of the operating field. In this article, we present our experience with exoscope-assisted septoplasty, developed over the last two years, and compare it with our extensive experience using the endoscopic approach. Methods: Our case series includes 26 patients, predominantly males and young adults, who underwent exoscope-assisted septoplasty. We discuss the primary advantages of this technique and, most importantly, provide an analysis of its learning curve. The cohort of patients treated using the exoscopic approach was compared with a control group of 26 patients who underwent endoscope-guided septoplasty, randomly selected from our broader clinical database. Finally, we present a representative surgical case that details all phases of the exoscope-assisted procedure. Results: Our surgical experience has demonstrated that exoscopy is a safe and effective tool for performing septoplasty. Moreover, the learning curve associated with this technique exhibits a rapid and progressive improvement. Notably, exoscopy provides a substantial educational benefit for trainees and medical students, as it enables them to share the same visual perspective as the lead surgeon. Conclusions: Although further studies are required to validate this approach, we believe that exoscopy represents a promising advancement for a wide range of head and neck procedures, and certainly for septoplasty. Full article
(This article belongs to the Special Issue Recent Advances in Reconstructive Oral and Maxillofacial Surgery)
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8 pages, 399 KiB  
Article
Bovine Pericardium Graft as a Salvage Option in Septoplasties at Risk of Septal Perforation
by Alvaro Sánchez Barrueco, Pilar Benavent Marín, Gonzalo Díaz Tapia, Ignacio Alcalá Rueda, William Aragonés Sanzen-Baker, Luz López Flórez, Jessica Mireya Santillán Coello and José Miguel Villacampa Aubá
J. Clin. Med. 2025, 14(13), 4592; https://doi.org/10.3390/jcm14134592 - 28 Jun 2025
Viewed by 370
Abstract
Background: Septoplasty is a widely performed surgical procedure to correct nasal septal deviations and improve respiratory function. One of its most significant complications is septal perforation, which can severely impact the patient’s quality of life. This study evaluates the use of bovine pericardium [...] Read more.
Background: Septoplasty is a widely performed surgical procedure to correct nasal septal deviations and improve respiratory function. One of its most significant complications is septal perforation, which can severely impact the patient’s quality of life. This study evaluates the use of bovine pericardium grafts to enhance mucosal healing, thereby reducing the risk of postoperative septal perforation in cases with intraoperative bilateral mucosal defects. Methods: A retrospective study was conducted on patients who underwent septoplasty between January 2018 and January 2025 in whom bovine pericardium grafts were interposed due to the presence of bilateral opposing mucosal defects. Epidemiological and surgical variables were recorded, and outcomes and complications were analyzed. Results: Out of the 4151 septoplasties performed, 30 cases (0.72%) required bovine pericardium interposition. The mean patient age was 42.87 years. Postoperative absence of septal perforation was confirmed in 90% of cases, with only three postoperative perforations, all asymptomatic and approximately 2 mm in size. Complications were recorded in three patients (10%), all of which were resolved with conservative treatment and without sequelae. Conclusions: For the first time in routine surgical practice, bovine pericardium emerges as a viable option for preventing postoperative septal perforation in cases with bilateral opposing mucosal defects. With a high closure rate and a low incidence of adverse events, this material represents a promising tool in septal surgery. Full article
(This article belongs to the Special Issue Otolaryngology—Head and Neck Surgery: Current Trends and Challenges)
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14 pages, 16518 KiB  
Article
Long-Term Outcomes of Crooked Nose Correction: The Value of Instrumental Diagnosis Trough Nasal Grid Analysis
by Riccardo Nocini
Diagnostics 2025, 15(9), 1121; https://doi.org/10.3390/diagnostics15091121 - 28 Apr 2025
Viewed by 527
Abstract
Background: Rhinoplasty is a leading cosmetic surgery, with the crooked nose being one of the most complex challenges due to its combination of functional and aesthetic issues. Involving multiple nasal components, a crooked nose remains difficult to correct, with a high recurrence [...] Read more.
Background: Rhinoplasty is a leading cosmetic surgery, with the crooked nose being one of the most complex challenges due to its combination of functional and aesthetic issues. Involving multiple nasal components, a crooked nose remains difficult to correct, with a high recurrence rate. The aim of this study was to analyze the long-term outcomes and stability of the nasal pyramid after surgery through a nasal grid analysis. Methods: A retrospective study was conducted on 360 patients (20 men and 16 women) treated for moderate to severe nasal deviation between January 2014 and January 2020. All patients underwent surgery by the same expert surgeon, with follow-ups extending to at least 24 months. Medical records, physical exams, and standardized photographic evaluations were used to assess outcomes. A nasal grid was adapted to analyze the long-term stability of nasal corrections, focusing on individual post-operative changes. Results: The study involved 360 patients, mostly men aged 22 to 65, with the majority having nasal deviations caused by extrinsic trauma (e.g., sports injuries). Nasal deviations affected various parts of the nose, and all patients underwent follow-up evaluations using a nasal grid to compare pre- and post-operative measurements. The results showed long-term stability in nasal corrections, with minimal changes observed between 1 month and 24 months post-surgery. Only one case had partial recurrence, requiring revision surgery, which was successful. Conclusions: The surgical correction of a crooked nose is complex and requires a personalized approach, particularly for severe septal deviations. Complete anatomical reconstruction, using advanced techniques like extracorporeal septal reconstruction and laser osteotomies, provides stable long-term results. The adapted nasal grid proved to be not only an effective post-operative assessment tool but also shows potential for the pre-operative classification of nasal deformity complexity. Although this study focused on a standardized surgical technique, future comparative analyses with alternative approaches are recommended to further validate the outcomes. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment in Otolaryngology)
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11 pages, 1162 KiB  
Article
Correlation Between Nasal Anatomical Variants and SNOT-22 in Patients Affected by Odontogenic Sinusitis: A Retrospective Study
by Federico Sireci, Filippo Cascio, Francesco Lorusso, Francesco Gazia, Angelo Immordino, Salvatore Gallina, Valerio Campofiorito, Andrea Comparetto, Ignazio Gerardi and Francesco Dispenza
J. Clin. Med. 2025, 14(7), 2337; https://doi.org/10.3390/jcm14072337 - 28 Mar 2025
Viewed by 666
Abstract
Objectives: The aim of this study is to analyze the correlation between the nasal anatomical variants and the clinical and radiological features of odontogenic sinusitis to demonstrate their possible involvement in the genesis of the disease. Methods: This is a retrospective [...] Read more.
Objectives: The aim of this study is to analyze the correlation between the nasal anatomical variants and the clinical and radiological features of odontogenic sinusitis to demonstrate their possible involvement in the genesis of the disease. Methods: This is a retrospective multicentric study of 70 patients with odontogenic sinusitis (OS). Before surgery, all patients performed the classic and mini 22-item Sino-Nasal Outcome Test (SNOT-22 and SNOT-8) and Lund–Mackay Score (LMS). Each nasal anatomical anomaly was collected, including paradoxical middle turbinate (PMT), chonca bullosa (CB), and nasal septal deviation (NSD) on the same side as the sinusitis. Results: The patients presented a significantly higher SNOT-22 and SNOT-8 score only in case of association with NSD and PMT/CB. Logistic regression showed that the variables were significantly associated (p = 0.02 and 0.04). No significant correlation was found between LMS and anatomical variations. Conclusions: This study showed that nasal anatomical variables are correlated with SNOT-22 and SNOT-8. Having a combination of NSD and CB or PMT, on the same side as an OS, is related to a worse quality of life in patients affected by this disease. Regarding the radiological features of OS, no significant correlation was found between LMS and anatomical variations. Full article
(This article belongs to the Section Otolaryngology)
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11 pages, 3788 KiB  
Article
Aesthetic and Functional Outcomes of Combined Use of Extended Spreader Graft and Septal Extension Graft
by Yung Jin Jeon, Tae-Hun Lee, Yeon-Hee Joo and Sang-Wook Kim
Life 2025, 15(4), 546; https://doi.org/10.3390/life15040546 - 26 Mar 2025
Viewed by 860
Abstract
Deviation of the cartilaginous midvault and caudal nasal septum can cause both aesthetic misalignment and functional impairment of the nasal valves. This study explores the technical considerations and outcomes of combining extended spreader graft and septal extension graft in septorhinoplasty to correct these [...] Read more.
Deviation of the cartilaginous midvault and caudal nasal septum can cause both aesthetic misalignment and functional impairment of the nasal valves. This study explores the technical considerations and outcomes of combining extended spreader graft and septal extension graft in septorhinoplasty to correct these deviations. A retrospective analysis of 24 patients who underwent primary septorhinoplasty between January 2022 and July 2023, performed by a single surgeon, was conducted with a mean follow-up of 11.28 months. Unilateral or bilateral extended spreader grafts and septal extension grafts were placed on the concave side of the deviation. Clinical charts, surgical records, standardized photographs, and acoustic rhinometry data were analyzed for objective and subjective outcomes. Among 24 patients (21 males, 3 females; mean age 35.2 ± 15.0 years), successful correction of C-shaped nasal deviation was achieved with no significant complications observed in the short-term follow-up (p < 0.0001). Functional improvements were observed in nasal volume and minimum cross-sectional area (p < 0.0001). Most patients reported high satisfaction with both functional and aesthetic outcomes. Compared to traditional septorhinoplasty techniques, this combined approach offers a structured method to address both cosmetic and functional concerns. These findings suggest that the combined use of extended spreader grafts and septal extension grafts offers a promising approach for addressing both cosmetic and functional concerns in septorhinoplasty. Full article
(This article belongs to the Section Medical Research)
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13 pages, 4512 KiB  
Article
The Nasal Septal Swell Body May Have a Regulatory Role in Nasal Airway Passage That Depends on the Degree of Septal Deviation
by Tomohisa Hirai, Takehiro Sera, Sachio Takeno, Yukako Okamoto, Tomohiro Kawasumi, Chie Ishikawa, Takashi Oda, Manabu Nishida, Yuichiro Horibe, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda and Nobuhisa Ishikawa
J. Otorhinolaryngol. Hear. Balance Med. 2025, 6(1), 5; https://doi.org/10.3390/ohbm6010005 - 4 Mar 2025
Viewed by 1389
Abstract
Background: The nasal septal swell body (NSB) is a thickened area of the nasal septum with erectile tissues, located above the nasal floor. We hypothesized that the presence of the NSB in this space exerts favorable effects to generate laminar nasal airflow by [...] Read more.
Background: The nasal septal swell body (NSB) is a thickened area of the nasal septum with erectile tissues, located above the nasal floor. We hypothesized that the presence of the NSB in this space exerts favorable effects to generate laminar nasal airflow by developing its morphology as adjusted to nasal septal deviation (NSD). Patients and Methods: We objectively measured the NSB morphology in 152 patients by computed tomography (CT) and assessed its relationship with the width of the inferior turbinate (IT), the severity of NSD, and the patency of the nasal airflow passage (NAP). Results: In the patients with moderate or severe NSD, the mean widths of the NSB, IT, and NAP were significantly narrower at the convex side compared to the paired concave side, with the degree being more prominent in the severe-NSD group. A positive correlation was observed between the degree of the NSD angles and the difference in the widths of the NSB (r = 0.805) and IT (r = 0.609). Conclusions: These results imply novel roles of the NSB in the maintenance of physiological nasal airflow to generate a laminar airflow from the nostrils toward the middle nasal meatus at a constant rate. Full article
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13 pages, 2335 KiB  
Article
Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache
by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci and Daniela Messineo
Diagnostics 2025, 15(2), 121; https://doi.org/10.3390/diagnostics15020121 - 7 Jan 2025
Viewed by 1146
Abstract
Background/Objectives: Rhinogenic contact point headache (RCPH) is a controversial secondary headache disorder involving mucosal contact points in the nasal sinuses. The efficacy of surgical versus medical management has been debated, with some studies showing excellent long-term outcomes but others citing placebo effects. This [...] Read more.
Background/Objectives: Rhinogenic contact point headache (RCPH) is a controversial secondary headache disorder involving mucosal contact points in the nasal sinuses. The efficacy of surgical versus medical management has been debated, with some studies showing excellent long-term outcomes but others citing placebo effects. This study aimed to clarify the correlation with nasal anatomical variation detected by CT and RCPH treatment outcomes. Methods: A prospective cohort study was conducted on 90 RCPH patients undergoing surgery or medical therapy. Patients were diagnosed using CT scans, endoscopy, and lidocaine testing. The surgery group had endoscopic procedures to remove contact points. The medical group received intranasal steroids. Outcomes were measured by visual analog scale (VAS) for pain and headache frequency. Predictors like age, gender, and nasal anatomical variations were analyzed. Results: The surgery group showed significant reductions in VAS scores (6.02 to 2.51, p < 0.001) and headache frequency (9.11 to 3.04, p < 0.001). The medical group did not improve significantly. All nasal subtypes improved with surgery but concha bullosa had worse VAS outcomes (4.0) than septal deviation (1.8, p < 0.001) or spur (1.73, p < 0.001). Multivariate analysis found nasal anomalies predicted postoperative VAS scores (p < 0.001) but not headache frequency (p = 0.255). Conclusions: Surgery demonstrated superiority over medications for RCPH. This study provides new evidence that preoperative CT scans should be considered a non-invasive gold standard for analyzing nasal subtypes as they significantly influence surgical success, with concha bullosa associated with worse pain relief. Larger studies should validate these findings to optimize RCPH management. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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11 pages, 2627 KiB  
Article
Patient Age Predicts Nasal Septal Deviation in Orthognathic Surgery: A Non-Randomized Clinical Trial of 102 Participants
by Juergen Taxis, Henrik-Robert Florian, Gerardo Napodano, Maximilian Rink, Felix Nieberle, Katja Himmelstoß, Sophia R. Lindner, Tobias Ettl, Torsten E. Reichert and Waltraud Waiss
Medicina 2024, 60(12), 2000; https://doi.org/10.3390/medicina60122000 - 3 Dec 2024
Viewed by 1305
Abstract
Background and Objectives: Orthognathic surgery is used to restore a correct anatomical and functional relationship between the jaws, with postoperative nasal septal deviation (NSD) being a common complication of Le Fort I osteotomy (LF-IO). The aim of this study was to evaluate [...] Read more.
Background and Objectives: Orthognathic surgery is used to restore a correct anatomical and functional relationship between the jaws, with postoperative nasal septal deviation (NSD) being a common complication of Le Fort I osteotomy (LF-IO). The aim of this study was to evaluate the occurrence of NSD after LF-IO and to identify possible risk factors. Materials and Methods: Pre- and postoperative cone beam computed tomography (CBCT) scans from 2018 to 2023 of 102 patients after LF-IO were analyzed. After categorizing the preoperative NSDs according to the Mladina classification, the next step was to measure the angle of deviation and classify the severity grades. Pre- and postoperative NSDs were compared using a paired Wilcoxon signed-rank test and postoperative changes in NSD were correlated with surgery-relevant characteristics by calculating Spearman’s correlation coefficients. Results: Postoperatively, an increase in NSD was observed in 62 cases and 35 patients showed a decrease. In both cases with an increase and a decrease in NSD, the preoperatively measured deviations showed a highly significant difference compared to postoperative NSDs (both p < 0.001). Age correlated significantly with increases in deviation (r = 0.28, p = 0.014, CI: −1.0–−0.068) and anterior maxillary displacement showed a significant correlation with a decrease in NSD (r = 0.296, p = 0.042, CI: 0.006–1.0). Gender, cranial and caudal movements of the maxilla had no influence on the results of the NSDs. Conclusions: LF-IO has an influence on NSD and can both intensify and attenuate it. In addition, the risk of an increase in nasal deviation after this surgical procedure rises with the patient’s age and decreases with anterior displacement of the maxilla. Full article
(This article belongs to the Special Issue Challenges and Features Facing Contemporary Orthognathic Surgery)
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8 pages, 417 KiB  
Article
Nasal Septal Deviation Classifications Associated with Revision Septoplasty
by Karina Bayer, Johannes Brady-Praun, Gerold Besser, Faris F. Brkic, Markus Haas, Christian A. Mueller and David T. Liu
J. Otorhinolaryngol. Hear. Balance Med. 2024, 5(2), 14; https://doi.org/10.3390/ohbm5020014 - 27 Sep 2024
Viewed by 2790
Abstract
Background: This study aimed to identify clinical characteristics and classifications of nasal septal deviations associated with revision septoplasty. Methods: The cross-sectional study design included 652 patients undergoing septoplasty at a tertiary referral center. We classified patients according to Baumann’s validated septal deviation classification [...] Read more.
Background: This study aimed to identify clinical characteristics and classifications of nasal septal deviations associated with revision septoplasty. Methods: The cross-sectional study design included 652 patients undergoing septoplasty at a tertiary referral center. We classified patients according to Baumann’s validated septal deviation classification and assessed similarities and differences regarding septal pathologies and types of nasal septal deviations in both groups. Results: The sample comprised 600 primary surgery cases and 52 revision cases. In primary surgeries, type 1 septal deviations were most common (60.3%), followed by type 5 (10.5%) and type 3 (10.0%). In revision surgeries, type 1 deviations (36.5%) were most common, followed by type 3 (25.0%) and type 2 (17.3%). Group comparisons revealed that type 2 and type 3 septal deviations, high septal deviations, and septal perforations were significantly more frequent in revision cases. Common septal pathologies included an oblique septum (98.0%), ipsilateral septal crest (76.4%), contralateral turbinal hyperplasia (42.5%), and vomeral spur (39.9%). Conclusions: This study suggests that using validated classification systems for septal deviations, which combine various pathologies, can provide a more clinically relevant assessment and improve patient counseling and treatment. Full article
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14 pages, 1210 KiB  
Article
Objective and Subjective Outcomes Following Radiofrequency of Inferior Turbinates in Patients with Sleep-Disordered Breathing
by Alfonso Luca Pendolino, Samit Unadkat, Ryan Chin Taw Cheong, Ankit Patel, Joshua Ferreira, Bruno Scarpa and Peter J. Andrews
Diagnostics 2024, 14(16), 1820; https://doi.org/10.3390/diagnostics14161820 - 21 Aug 2024
Viewed by 1897
Abstract
Background: Nasal obstruction is a frequent problem amongst patients with sleep-disordered breathing (SDB). Radiofrequency of the inferior turbinates (RFIT) is commonly utilized for inferior turbinate (IT) reduction but its effectiveness in SDB patients remains unproven. We aim to evaluate long-term objective and subjective [...] Read more.
Background: Nasal obstruction is a frequent problem amongst patients with sleep-disordered breathing (SDB). Radiofrequency of the inferior turbinates (RFIT) is commonly utilized for inferior turbinate (IT) reduction but its effectiveness in SDB patients remains unproven. We aim to evaluate long-term objective and subjective nasal, olfactory and sleep outcomes following RFIT in SDB patients. Methods: Patients were assessed at baseline (T0) and at 3 months (T1), 6 months (T2) and 12 months (T3) following RFIT. At T0, T1, T2 and T3, the patients underwent objective assessments of their nasal airways and smell function and an evaluation of their quality-of-life, sinonasal, olfactory and sleep symptoms. Sleep studies were carried out at T0 and T2. Results: Seventeen patients (with a median age of 42 years) underwent RFIT. A statistically significant objective and subjective improvement of the patients’ nasal airways was demonstrated at T1. No other statistically significant changes were observed in the patients’ nasal airways, smell, sleep study parameters or patient-reported outcomes at the other follow-ups. A multivariate analysis confirmed a statistically significant influence of age (older), sex (male), a higher BMI, the presence of septal deviation and the presence of allergic rhinitis in some of the studies’ parameters. A statistically significant objective and subjective improvement of the patients’ nasal airways was confirmed in the fitted model when considering the influence of the available variables. Conclusions: Our study confirms that the benefits of RFIT alone in SDB patients are limited and possibly only in the short-term period. Patient-related variables can potentially influence the final outcomes. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Sinonasal Disorders)
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6 pages, 6409 KiB  
Case Report
Complete Left-Sided Pericardial Congenital Absence
by Petar Kalaydzhiev, Anelia Partenova, Radostina Ilieva, Kamelia Genova and Elena Kinova
Reports 2024, 7(2), 48; https://doi.org/10.3390/reports7020048 - 20 Jun 2024
Viewed by 1587
Abstract
Background: Congenital absence of pericardium is a rare cardiac disorder with a reported incidence of less than 1 in 10,000. Although most of the cases are of little clinical significance, some of them are associated with serious complications, including risk of herniation and [...] Read more.
Background: Congenital absence of pericardium is a rare cardiac disorder with a reported incidence of less than 1 in 10,000. Although most of the cases are of little clinical significance, some of them are associated with serious complications, including risk of herniation and strangulation or coronary artery compression. Detailed Case Description: We report a case of a 36-year-old male referred for routine cardiovascular examination. He had a medical history of a heart murmur since childhood. Electrocardiogram (ECG) revealed sinus rhythm, normal axis, poor R-wave progression in the precordial leads and repolarization abnormalities with negative T waves in leads V1–V4. On 2D transthoracic echocardiography (TTE), an unusual heart position was noted with poor image quality from the standard acoustic windows. The parasternal long axis view gave the impression of right ventricular dilatation. The findings raised the suspicion of left to right shunt and possible atrial septal defect. For further evaluation, the patient was referred for cardiac magnetic resonance which demonstrated complete left-sided absence of the pericardium. Discussion: Due to indistinct and atypical symptoms and lack of clinical awareness, pericardial congenital absence is frequently misdiagnosed. Patients may complain of atypical chest pain. Patient’s history and physical examination are often nonspecific. In cases with complete pericardial absence, ECG findings may include right axis deviation, right bundle block and sinus bradycardia. Echocardiography findings are also not characteristic, but some may raise the clinical suspicion of this diagnosis. The imaging modalities of choice are computed tomography and cardiac magnetic resonance. Treatment depends on the type of defect and clinical symptoms. Full article
(This article belongs to the Section Cardiology/Cardiovascular Medicine)
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13 pages, 3022 KiB  
Article
Comparison of Nasal Dimensions According to the Facial and Nasal Indices Using Cone-Beam Computed Tomography
by Jeong-Hyun Lee, Hey-Suk Kim and Jong-Tae Park
J. Pers. Med. 2024, 14(4), 415; https://doi.org/10.3390/jpm14040415 - 14 Apr 2024
Cited by 2 | Viewed by 2433
Abstract
The nasal cavity constitutes the foremost portion of the respiratory system, composed of the anterior nasal aperture, nostrils, and choanae. It has an intricate anatomical structure since it has various functions, such as heat exchange, humidification, and filtration. Accordingly, clinical symptoms related to [...] Read more.
The nasal cavity constitutes the foremost portion of the respiratory system, composed of the anterior nasal aperture, nostrils, and choanae. It has an intricate anatomical structure since it has various functions, such as heat exchange, humidification, and filtration. Accordingly, clinical symptoms related to the nose, such as nasal congestion, snoring, and nasal septal deviation, are closely linked to the complex anatomical structure of the nasal cavity. Thus, the nasal cavity stands as a paramount structure in both forensic and clinical contexts. The majority of relevant studies have performed comparisons between sexes, with studies making comparisons according to the FI and NI only and examining relative percentages. Furthermore, the nasal cavity was measured in 2D, and not 3D, in most cases. In this study, we conducted a 3D modeling and anthropometric assessment of the nasal cavity using a 3D analysis software. Furthermore, we aimed to investigate whether the size of the nasal cavity differs according to sex, facial index (FI), and nasal index (NI). We retrospectively reviewed the cone-beam computed tomography (CBCT) data of 100 participants (50 males, 50 females) aged 20–29 years who visited the dental hospital of Dankook University (IRB approval no. DKUDH IRB 2020-01-007). Our findings showed that nasal cavity sizes generally differed according to sex, FI, and NI. These findings provide implications for performing patient-tailored surgeries in clinical practice and conducting further research on the nasal cavity. Therefore, we believe that our study makes a significant contribution to the literature. Full article
(This article belongs to the Special Issue New Updates in Oral and Maxillofacial Surgery)
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14 pages, 1406 KiB  
Article
Relationship of Maxillary Sinus Volume and Nasal Septum Deviation: A Cone Beam Computed Tomography Study
by Amanda B. Rodriguez Betancourt, Leidy J. Martinez Somoza, Carlos Romero Mesa, Tolga Fikret Tozum, Carlos Fernando Mourão, Jamil Awad Shibli and Lina J. Suárez
Diagnostics 2024, 14(6), 647; https://doi.org/10.3390/diagnostics14060647 - 19 Mar 2024
Cited by 2 | Viewed by 2845
Abstract
The present study was designed to test the hypothesis that there would be a correlation between nasal septum deviation (NSD) and a decreased maxillary sinus volume (MSV) in a Colombian population, using Cone Beam Computed Tomography (CBCT); other sinusal anatomical structures found during [...] Read more.
The present study was designed to test the hypothesis that there would be a correlation between nasal septum deviation (NSD) and a decreased maxillary sinus volume (MSV) in a Colombian population, using Cone Beam Computed Tomography (CBCT); other sinusal anatomical structures found during the reading were described and analyzed. A retrospective analysis of 537 CBCT scans of adult patients taken between January 2014 and January 2017 included measuring the maxillary sinus diameter in the vertical, horizontal, and sagittal planes. NSD was quantified and related to MSV using the same field of view (FOV). The volume of the right and left maxillary sinuses showed a median and interquartile range (IQR) of 8.18 mm3 (IQR: 6.2–10.33) and 8.3 mm3 (IQR: 6.4–10.36). Statistically significant differences were observed between sex and right and left MSV (p = 0.000), with higher MSV in men. The presence of NSD was observed in 96.81% of the sample and was evaluated in degrees, observing a median of 11° (IQR: 7–16) where 40% of the sample had moderate angles (9–15°). There was no correlation between NSD and a decreased MSV in the population studied. Detailed CBCT analysis with a large FOV is crucial for the analysis of anatomical structures before performing surgical procedures that involve the MS as a preventive diagnostic and therapeutic step for appropriate treatment. Full article
(This article belongs to the Special Issue Advances in Oral and Maxillofacial Radiology)
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10 pages, 2066 KiB  
Article
Upregulation of Platelet-Activating Factor Receptor Expression and Lyso-Platelet-Activating Factor Isoforms in Human Nasal Polyp Tissues
by Jordi Roca-Ferrer, Maria Pérez-González, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantulà, Rosa Muñoz-Cano, Antonio Valero, Iñaki Izquierdo and Joaquim Mullol
J. Clin. Med. 2023, 12(23), 7357; https://doi.org/10.3390/jcm12237357 - 28 Nov 2023
Cited by 1 | Viewed by 1712
Abstract
Background: The Platelet-Activating Factor (PAF)/receptor (PAFR) system is involved in asthma and allergic rhinitis; however, its role in chronic rhinosinusitis (CRS) is still unclear. This study aimed to assess the expression of PAFR and the concentration of Lyso-PAF isoforms in the nasal polyps [...] Read more.
Background: The Platelet-Activating Factor (PAF)/receptor (PAFR) system is involved in asthma and allergic rhinitis; however, its role in chronic rhinosinusitis (CRS) is still unclear. This study aimed to assess the expression of PAFR and the concentration of Lyso-PAF isoforms in the nasal polyps (NP) of patients suffering from CRS with/without comorbidities such as asthma and NSAID-exacerbated respiratory disease (N-ERD) compared to healthy nasal mucosa (NM) from control subjects. Methods: NM (n = 8) and NP tissues were obtained from patients undergoing surgery for septal deviation/turbinate hypertrophy or endoscopic sinus surgery, respectively. Three phenotypes were studied: CRSwNP with no asthma (n = 6), CRSwNP with non-steroidal anti-inflammatory drug (NSAID)-tolerant asthma (n = 6), and CRSwNP with NSAID-exacerbated respiratory disease (n = 6). PAFR protein and mRNA were assessed via immunochemistry, immunofluorescence, Western blot, and real-time quantitative PCR. Lyso-PAF isoforms (C16, C18, and C18:1) were quantified via mass spectrometry. Results: PAFR protein was expressed in the NM and NP, concretely in epithelial cells and submucosal glands. Compared to NM, PAFR mRNA expression was higher in all NP phenotypes (p < 0.05) while all Lyso-PAF isoform concentrations were higher in the NP from asthmatic patients (p < 0.05). Lyso-PAF C16 and C18 concentrations were higher in the NP from asthmatic patients than in the NP from patients without asthma. Conclusions: The PAF/PAFR system could play a pathophysiological role in CRSwNP pathogenesis. Full article
(This article belongs to the Section Otolaryngology)
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14 pages, 3466 KiB  
Article
Correlation Analysis of Nasal Septum Deviation and Results of AI-Driven Automated 3D Cephalometric Analysis
by Natalia Kazimierczak, Wojciech Kazimierczak, Zbigniew Serafin, Paweł Nowicki, Adam Lemanowicz, Katarzyna Nadolska and Joanna Janiszewska-Olszowska
J. Clin. Med. 2023, 12(20), 6621; https://doi.org/10.3390/jcm12206621 - 19 Oct 2023
Cited by 9 | Viewed by 2680
Abstract
The nasal septum is believed to play a crucial role in the development of the craniofacial skeleton. Nasal septum deviation (NSD) is a common condition, affecting 18–65% of individuals. This study aimed to assess the prevalence of NSD and its potential association with [...] Read more.
The nasal septum is believed to play a crucial role in the development of the craniofacial skeleton. Nasal septum deviation (NSD) is a common condition, affecting 18–65% of individuals. This study aimed to assess the prevalence of NSD and its potential association with abnormalities detected through cephalometric analysis using artificial intelligence (AI) algorithms. The study included CT scans of 120 consecutive, post-traumatic patients aged 18–30. Cephalometric analysis was performed using an AI web-based software, CephX. The automatic analysis comprised all the available cephalometric analyses. NSD was assessed using two methods: maximum deviation from an ideal non-deviated septum and septal deviation angle (SDA). The concordance of repeated manual measurements and automatic analyses was assessed. Of the 120 cases, 90 met the inclusion criteria. The AI-based cephalometric analysis provided comprehensive reports with over 100 measurements. Only the hinge axis angle (HAA) and SDA showed significant (p = 0.039) negative correlations. The rest of the cephalometric analyses showed no correlation with the NSD indicators. The analysis of the agreement between repeated manual measurements and automatic analyses showed good-to-excellent concordance, except in the case of two angular measurements: LI-N-B and Pr-N-A. The CephX AI platform showed high repeatability in automatic cephalometric analyses, demonstrating the reliability of the AI model for most cephalometric analyses. Full article
(This article belongs to the Special Issue Clinical Advances in Head and Neck Imaging including Dentistry)
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