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20 pages, 8469 KiB  
Review
Electrochemical Biosensors for Oilseed Crops: Nanomaterial-Driven Detection and Smart Agriculture
by Youwei Jiang, Kun Wan, Aiting Chen, Nana Tang, Na Liu, Tao Zhang, Qijun Xie and Quanguo He
Foods 2025, 14(16), 2881; https://doi.org/10.3390/foods14162881 (registering DOI) - 20 Aug 2025
Abstract
Electrochemical biosensors have emerged as a promising tool for the early detection of diseases in oilseed crops such as rapeseed, soybean, and peanut. These biosensors offer high sensitivity, portability, and cost-effectiveness. Timely diagnosis is critical, as many pathogens exhibit latent infection phases or [...] Read more.
Electrochemical biosensors have emerged as a promising tool for the early detection of diseases in oilseed crops such as rapeseed, soybean, and peanut. These biosensors offer high sensitivity, portability, and cost-effectiveness. Timely diagnosis is critical, as many pathogens exhibit latent infection phases or produce invisible metabolic toxins, leading to substantial yield losses before visible symptoms occur. This review summarises recent advances in the field of nanomaterial-assisted electrochemical sensing for oilseed crop diseases, with a particular focus on sensor mechanisms, interface engineering, and biomolecular recognition strategies. The following innovations are highlighted: nanostructured electrodes, aptamer- and antibody-based probes, and signal amplification techniques. These innovations have enabled the detection of pathogen DNA, enzymes, and toxins at ultra-low concentrations. Notwithstanding these achievements, challenges persist, including signal interference from plant matrices, limitations in device miniaturization, and the absence of standardized detection protocols. Future research should explore the potential of AI-assisted data interpretation, the use of biodegradable sensor materials, and the integration of these technologies with agricultural IoT networks. The aim of this integration is to enable real-time, field-deployable disease surveillance. The integration of laboratory innovations with field applications has been demonstrated to have significant potential in supporting sustainable agriculture and strengthening food security through intelligent crop health monitoring. Full article
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13 pages, 690 KiB  
Article
Design and Optimization of Polarization-Maintaining Low-Loss Hollow-Core Anti-Resonant Fibers Based on a Multi-Objective Genetic Algorithm
by Zhiling Li, Yingwei Qin, Jingjing Ren, Xiaodong Huang and Yanan Bao
Photonics 2025, 12(8), 826; https://doi.org/10.3390/photonics12080826 (registering DOI) - 20 Aug 2025
Abstract
In this work, a novel polarization-maintaining hollow-core fiber structure featuring a semi-circular nested dual-ring geometry is proposed. To simultaneously optimize two inherently conflicting performance metrics, namely, birefringence and confinement loss, a multi objective genetic algorithm is employed for geometric parameter tuning, resulting in [...] Read more.
In this work, a novel polarization-maintaining hollow-core fiber structure featuring a semi-circular nested dual-ring geometry is proposed. To simultaneously optimize two inherently conflicting performance metrics, namely, birefringence and confinement loss, a multi objective genetic algorithm is employed for geometric parameter tuning, resulting in a set of Pareto-optimal solutions. At the target wavelength of 1550 nm, the first optimal design achieves birefringence exceeding 1×104 over a 1275 nm bandwidth while maintaining confinement loss around 100 dB/m; the second design maintains birefringence above 1×104 across a 1000 nm spectral range, with confinement loss on the order of 101 dB/m. These optimized designs offer a promising approach for improving the performance of polarization-sensitive applications such as interferometric sensing and high coherence laser systems. The results confirm the suitability of multi-objective genetic algorithms for integrated multi-objective fiber optimization and provide a new strategy for designing low-loss and high-birefringence fiber devices. Full article
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36 pages, 2830 KiB  
Review
Real-Time, Continuous Monitoring of Tissue Chips as an Emerging Opportunity for Biosensing
by John S. Cognetti and Benjamin L. Miller
Sensors 2025, 25(16), 5153; https://doi.org/10.3390/s25165153 - 19 Aug 2025
Abstract
Tissue chips (TCs), otherwise known as organs-on-a-chip (OoC), organ chips (OCs), or microphysiological systems (MPS), are rapidly gaining prominence as an extension of or even replacement for traditional animal models of disease physiology. They also have recognized utility in the context of drug [...] Read more.
Tissue chips (TCs), otherwise known as organs-on-a-chip (OoC), organ chips (OCs), or microphysiological systems (MPS), are rapidly gaining prominence as an extension of or even replacement for traditional animal models of disease physiology. They also have recognized utility in the context of drug development: for example, data from TCs can now be submitted in place of some animal testing to the FDA. In principle, TCs are structured to allow measurement of any number of outputs that yield information about the tissue. However, to date, measurements made during experiments with TCs have been largely restricted to immunofluorescence microscopy and benchtop assays performed on media extracted from the cell culture within the device. With the development of biosensors that are sensitive and have an ever-shrinking footprint, on-board biosensing is now in the early stages of exploration. This review discusses the importance of tissue chips and the advances in sensing that will aid the complexity and utility of tissue chip research moving forward. We cover several sensing modalities, including electrical and optical sensing modes. Finally, challenges and opportunities for the future are discussed. Full article
(This article belongs to the Special Issue Feature Review Papers in Optical Sensors)
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19 pages, 6768 KiB  
Article
Two-Stage Online Task Assignment in Mobile Crowdsensing
by Hongjian Zeng, Yonghua Xiong and Jinhua She
Appl. Sci. 2025, 15(16), 9094; https://doi.org/10.3390/app15169094 - 18 Aug 2025
Abstract
The development of modern communication technologies and smart mobile devices has driven the evolution of mobile crowdsensing (MCS). Optimizing the task assignment process under constrained resources to maximize utility is a key challenge in MCS. However, most existing studies presuppose a sufficient pool [...] Read more.
The development of modern communication technologies and smart mobile devices has driven the evolution of mobile crowdsensing (MCS). Optimizing the task assignment process under constrained resources to maximize utility is a key challenge in MCS. However, most existing studies presuppose a sufficient pool of available workers during the task assignment process, overlooking the impact of temporal fluctuations in worker numbers under online scenarios. Additionally, existing studies commonly publish sensing tasks to the MCS platform for immediate assignment upon their arrival. However, the uncertainty in the number of available workers in online scenarios may fail to meet task demands. To address these challenges, this paper proposes a two-stage online task assignment scheme. The first stage introduces an adaptive task pre-assignment strategy based on worker quantity prediction, which determines task acceptance and assigns tasks to suitable subareas. The second stage employs a dynamic online recruitment method to select workers for the assigned tasks, aiming to maximize platform utility. Finally, the simulation experiments conducted on two real-world datasets demonstrate that the proposed methods effectively solve the challenges of online task assignment in MCS. Full article
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14 pages, 1167 KiB  
Article
REEV SENSE IMUs for Gait Analysis in Stroke: A Clinical Study on Lower Limb Kinematics
by Thibault Marsan, Sacha Clauzade, Xiang Zhang, Nicolas Grandin, Tatiana Urman, Evan Linton, Ingy Elsayed-Aly, Catherine E. Ricciardi and Robin Temporelli
Sensors 2025, 25(16), 5123; https://doi.org/10.3390/s25165123 - 18 Aug 2025
Abstract
Human gait analysis is essential for clinical evaluation and rehabilitation monitoring, particularly in post-stroke individuals, where joint kinematics provide valuable insights into motor recovery. While optical motion capture (OMC) is the gold standard, its high cost and restricted use in laboratory settings limit [...] Read more.
Human gait analysis is essential for clinical evaluation and rehabilitation monitoring, particularly in post-stroke individuals, where joint kinematics provide valuable insights into motor recovery. While optical motion capture (OMC) is the gold standard, its high cost and restricted use in laboratory settings limit its accessibility. This study aimed to evaluate the accuracy of REEV SENSE, a novel magnetometer-free inertial measurement unit (IMU), in capturing knee and ankle joint angles during overground walking in post-stroke individuals using assistive devices. Twenty participants with chronic stroke walked along a 10-m walkway with their usual assistive device (cane or walker), while joint kinematics were simultaneously recorded using OMC and IMUs. Agreement between the systems was assessed using the mean absolute error, root mean square error, 95% confidence intervals, and Pearson’s correlation coefficient. Knee angles measured with the IMUs showed a strong correlation with the OMC (r > 0.9) and low errors (MAE < 5°), consistent with clinical acceptability. Ankle angle accuracy was lower for participants using walkers, while knee measurements remained stable regardless of the assistive device. These findings demonstrate that REEV SENSE IMUs provide clinically relevant kinematic data and support their use as a practical wearable tool for gait analysis in real-world or remote clinical settings. Full article
(This article belongs to the Special Issue Wearable Inertial Sensors for Human Movement Analysis)
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7 pages, 1290 KiB  
Communication
Direct Nanoparticle Sensing in Liquids with Free-Space Excited Optical Whispering-Gallery-Mode Microresonators
by Davide D’Ambrosio, Saverio Avino and Gianluca Gagliardi
Sensors 2025, 25(16), 5111; https://doi.org/10.3390/s25165111 - 18 Aug 2025
Abstract
Whispering-gallery-mode (WGM) microresonators are amongst the most promising optical sensors for detecting bio-chemical targets. A number of laser interrogation methods have been proposed and demonstrated over the last decade, based on scattering and absorption losses or resonance splitting and shift, harnessing the high-quality [...] Read more.
Whispering-gallery-mode (WGM) microresonators are amongst the most promising optical sensors for detecting bio-chemical targets. A number of laser interrogation methods have been proposed and demonstrated over the last decade, based on scattering and absorption losses or resonance splitting and shift, harnessing the high-quality factor and ultra-small volume of WGMs. Actually, regardless of the sensitivity enhancement, their practical sensing operation may be hampered by the complexity of coupling devices as well as the signalprocessing required to extract the WGM response. Here, we use a silica microsphere immersed in an aqueous environment and efficiently excite optical WGMs with a free-space visible laser, thus collecting the relevant information from the transmitted and back-scattered light without any optical coupler, fiber, or waveguide. We show that a 640-nm diode laser, actively frequency-locked on resonance, provides real-time, fast sensing of dielectric nanoparticles approaching the surface with direct analog readout. Thanks to our illumination scheme, the sensor can be kept in water and operate for days without degradation or loss of sensitivity. Diverse noise contributions are carefully considered and quantified in our system, showing a minimum detectable particle size below 1 nm essentially limited by the residual laser microcavity jitter. Further analysis reveals that the inherent laserfrequency instability in the short, -mid-term operation regime sets an ultimate bound of 0.3 nm. Based on this work, we envisage the possibility to extend our method in view of developing new viable approaches for detection of nanoplastics in natural water without resorting to complex chemical laboratory methods. Full article
(This article belongs to the Section Communications)
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41 pages, 6372 KiB  
Review
Metal–Organic-Framework-Based Optical Biosensors: Recent Advances in Pathogen Detection and Environmental Monitoring
by Alemayehu Kidanemariam and Sungbo Cho
Sensors 2025, 25(16), 5081; https://doi.org/10.3390/s25165081 - 15 Aug 2025
Viewed by 146
Abstract
Metal–organic frameworks (MOFs) have emerged as highly versatile materials for the development of next-generation optical biosensors owing to their tunable porosity, large surface area, and customizable chemical functionality. Recently, MOF-based platforms have shown substantial potential in various optical transduction modalities, including fluorescence, luminescence, [...] Read more.
Metal–organic frameworks (MOFs) have emerged as highly versatile materials for the development of next-generation optical biosensors owing to their tunable porosity, large surface area, and customizable chemical functionality. Recently, MOF-based platforms have shown substantial potential in various optical transduction modalities, including fluorescence, luminescence, and colorimetric sensing, enabling the highly sensitive and selective detection of biological analytes. This review provides a comprehensive overview of recent advancements in MOF-based optical biosensors, focusing on their applications in pathogen detection and environmental monitoring. We highlight key design strategies, including MOF functionalization, hybridization with nanoparticles or dyes, and integration into microfluidic and wearable devices. Emerging methods, such as point-of-care diagnostics, label-free detection, and real-time monitoring, are also discussed. Finally, the current challenges and future directions for the practical deployment of MOF-based optical biosensors in clinical and field environments are discussed. Full article
(This article belongs to the Special Issue Feature Review Papers in Biosensors Section 2025)
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20 pages, 3967 KiB  
Article
A Flexible Frequency-Coded Electromagnetic Sensing Array for Contactless Biological Tissues Health Monitoring
by Angelica Masi, Danilo Brizi, Eliana Canicattì, Sabrina Rotundo and Agostino Monorchio
Appl. Sci. 2025, 15(16), 9015; https://doi.org/10.3390/app15169015 - 15 Aug 2025
Viewed by 120
Abstract
In this study, we present a wearable sensing system for monitoring the physiological status of damaged biological tissues based on a flexible, frequency-coded electromagnetic spiral resonator array. The physiological parameter evaluation is performed in a contactless way, avoiding the placing of electronically active [...] Read more.
In this study, we present a wearable sensing system for monitoring the physiological status of damaged biological tissues based on a flexible, frequency-coded electromagnetic spiral resonator array. The physiological parameter evaluation is performed in a contactless way, avoiding the placing of electronically active elements directly upon the patient’s skin, thus ensuring safety and comfort. Firstly, we report in detail the physical principles behind the sensing strategy: a passive array is interrogated through an actively fed external single-loop probe that is inductively coupled with the double-layer spiral unit cells. The variation in the physiological parameters influences the array response, thus providing sensing information, due to the different complex dielectric permittivity values related to the tissue status. Moreover, the proposed frequency-coded approach allows for spatial information on the lesion to be retrieved, thus increasing the sensing ability. In order to prove the validity of this general methodology, we created a numerical test case, designing a practical implementation of the wearable sensing system working at a radiofrequency regime (10–100 MHz). In addition, we also fabricated prototypes, exploiting PCB technology, and realized stratified phantoms by incorporating opportune additives to control the dielectric properties. The numerical results and the experimental verification demonstrated the validity of the developed sensing strategy, showing satisfying agreement and, thus, proving the good sensibility and spatial resolution of the frequency-coded array. These results can open the path to a radically novel approach for self-care and monitoring of inflamed status and, more generally, for wearable sensing devices in biomedical applications. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
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28 pages, 2383 KiB  
Article
CIM-LP: A Credibility-Aware Incentive Mechanism Based on Long Short-Term Memory and Proximal Policy Optimization for Mobile Crowdsensing
by Sijia Mu and Huahong Ma
Electronics 2025, 14(16), 3233; https://doi.org/10.3390/electronics14163233 - 14 Aug 2025
Viewed by 121
Abstract
In the field of mobile crowdsensing (MCS), a large number of tasks rely on the participation of ordinary mobile device users for data collection and processing. This model has shown great potential for applications in environmental monitoring, traffic management, public safety, and other [...] Read more.
In the field of mobile crowdsensing (MCS), a large number of tasks rely on the participation of ordinary mobile device users for data collection and processing. This model has shown great potential for applications in environmental monitoring, traffic management, public safety, and other areas. However, the enthusiasm of participants and the quality of uploaded data directly affect the reliability and practical value of the sensing results. Therefore, the design of incentive mechanisms has become a core issue in driving the healthy operation of MCS. The existing research, when optimizing long-term utility rewards for participants, has often failed to fully consider dynamic changes in trustworthiness. It has typically relied on historical data from a single point in time, overlooking the long-term dependencies in the time series, which results in suboptimal decision-making and limits the overall efficiency and fairness of sensing tasks. To address this issue, a credibility-aware incentive mechanism based on long short-term memory and proximal policy optimization (CIM-LP) is proposed. The mechanism employs a Markov decision process (MDP) model to describe the decision-making process of the participants. Without access to global information, an incentive model combining long short-term memory (LSTM) networks and proximal policy optimization (PPO), collectively referred to as LSTM-PPO, is utilized to formulate the most reasonable and effective sensing duration strategy for each participant, aiming to maximize the utility reward. After task completion, the participants’ credibility is dynamically updated by evaluating the quality of the uploaded data, which then adjusts their utility rewards for the next phase. Simulation results based on real datasets show that compared with several existing incentive algorithms, the CIM-LP mechanism increases the average utility of the participants by 6.56% to 112.76% and the task completion rate by 16.25% to 128.71%, demonstrating its significant advantages in improving data quality and task completion efficiency. Full article
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12 pages, 11986 KiB  
Article
Design of Long-Wave Fully Polarized HgCdTe Photodetector Based on Silicon Metasurface
by Bo Cheng, Xiaoming Wang, Yuxiao Zou, Guofeng Song, Kunpeng Zhai and Xiaojun Wang
Micromachines 2025, 16(8), 937; https://doi.org/10.3390/mi16080937 - 14 Aug 2025
Viewed by 240
Abstract
Polarization-sensitive photodetection is critical for advanced optical systems, yet achieving simultaneous high-fidelity recognition of the circularly polarized (CP) and linearly polarized (LP) light with compact designs remains challenging. Here, we use COMSOL 5.6 software to demonstrate a silicon metasurface-integrated MCT photodetector that resolves [...] Read more.
Polarization-sensitive photodetection is critical for advanced optical systems, yet achieving simultaneous high-fidelity recognition of the circularly polarized (CP) and linearly polarized (LP) light with compact designs remains challenging. Here, we use COMSOL 5.6 software to demonstrate a silicon metasurface-integrated MCT photodetector that resolves both CP and LP signals through a single ultrathin platform. The device deciphers LP states via four orientation-specific linear gratings for differential detection, while chiral symmetric silicon nanostructures enable direct CP discrimination with an exceptional extinction ratio of 30 dB. The proposed architecture combines two breakthroughs: (1) superior polarization reconstruction capability, achieved via the synergy of grating-induced polarization selectivity and chiral near-field enhancement, and (2) a fabrication-simplified process that eliminates multilayer stacking or complex alignment steps. This work establishes a new paradigm for miniaturized, high-performance polarization optics, with potential applications in polarization imaging, quantum communication, and hyperspectral sensing. Full article
(This article belongs to the Special Issue Photonic and Optoelectronic Devices and Systems, Third Edition)
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18 pages, 4856 KiB  
Article
Comparative Analysis of Multispectral LED–Sensor Architectures for Scalable Waste Material Classification
by Anju Manakkakudy Kumaran, Rahmi Elagib, Andrea De Iacovo, Andrea Ballabio, Jacopo Frigerio, Giovanni Isella, Gaetano Assanto and Lorenzo Colace
Appl. Sci. 2025, 15(16), 8964; https://doi.org/10.3390/app15168964 - 14 Aug 2025
Viewed by 110
Abstract
We present a comprehensive study of LED-based optical sensing systems for the classification of waste materials, analyzing recent developments in the field. Accurate identification of materials such as plastics, glass, aluminum, and paper is a crucial yet challenging task in waste management for [...] Read more.
We present a comprehensive study of LED-based optical sensing systems for the classification of waste materials, analyzing recent developments in the field. Accurate identification of materials such as plastics, glass, aluminum, and paper is a crucial yet challenging task in waste management for recycling. The first approach uses short-wave infrared reflectance spectroscopy with commercial Germanium photodetectors and selected LEDs to keep data complexity and cost at a minimum while achieving classification accuracies up to 98% with machine learning algorithms. The second system employes a voltage-tunable Germanium-on-Silicon photodetector that operates across a broader spectral range (400–1600 nm), in combination with three LEDs in both the visible and short-wave infrared bands. This configuration enables an adaptive spectral response and simplifies the optical setup, supporting energy-efficient and scalable integration. Accuracies up to 99% were obtained with the aid of machine learning algorithms. Across all systems, the strategic use of low-cost LEDs as light sources and compact optical sensors demonstrates the potential of light-emitting devices in the implementation of compact, intelligent, and sustainable solutions for real-time material recognition. This article explores the design, characterization, and performance of such systems, providing insights into the way light-emitting and optoelectronic components can be leveraged for advanced sensing in waste classification applications. Full article
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11 pages, 1072 KiB  
Article
Design and Characteristic Simulation of Polarization-Maintaining Anti-Resonant Hollow-Core Fiber for 2.79 μm Er, Cr: YSGG Laser Transmission
by Lei Huang and Yinze Wang
Optics 2025, 6(3), 37; https://doi.org/10.3390/opt6030037 - 14 Aug 2025
Viewed by 84
Abstract
Anti-resonant hollow-core fibers have exhibited excellent performance in applications such as high-power pulse transmission, network communication, space exploration, and precise sensing. Employing anti-resonant hollow-core fibers instead of light guiding arms for transmitting laser energy at the 2.79 μm band can significantly enhance the [...] Read more.
Anti-resonant hollow-core fibers have exhibited excellent performance in applications such as high-power pulse transmission, network communication, space exploration, and precise sensing. Employing anti-resonant hollow-core fibers instead of light guiding arms for transmitting laser energy at the 2.79 μm band can significantly enhance the flexibility of medical laser handles, reduce system complexity, and increase laser transmission efficiency. Nevertheless, common anti-resonant hollow-core fibers do not have the ability to maintain the polarization state of light during laser transmission, which greatly affects their practical applications. In this paper, we propose a polarization-maintaining anti-resonant hollow-core fiber applicable for transmission at the mid-infrared 2.79 μm band. This fiber features a symmetrical geometric structure and an asymmetric refractive index cladding composed of quartz and a type of mid-infrared glass with a higher refractive index. Through optimizing the fiber structure at the wavelength scale, single-polarization transmission can be achieved at the 2.79 μm wavelength, with a polarization extinction ratio exceeding 1.01 × 105, indicating its stable polarization-maintaining performance. Simultaneously, it possesses low-loss transmission characteristics, with the loss in the x-polarized fundamental mode being less than 9.8 × 10−3 dB/m at the 2.79 µm wavelength. This polarization-maintaining anti-resonant hollow-core fiber provides a more reliable option for the light guiding system of the 2.79 μm Er; Cr: YSGG laser therapy device. Full article
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15 pages, 3400 KiB  
Article
Ti3C2TX MXene/Polyaniline-Modified Nylon Fabric Electrode for Wearable Non-Invasive Glucose Monitoring in Sweat
by Lichao Wang, Meng Li, Shengnan Ya, Hang Tian, Kerui Li, Qinghong Zhang, Yaogang Li, Hongzhi Wang and Chengyi Hou
Biosensors 2025, 15(8), 531; https://doi.org/10.3390/bios15080531 - 14 Aug 2025
Viewed by 261
Abstract
Sweat-based electrochemical sensors for wearable applications have attracted substantial interest due to their non-invasive nature, compact design, and ability to provide real-time data. Remarkable advancements have been made in integrating these devices into flexible platforms. While thin-film polymer substrates are frequently employed for [...] Read more.
Sweat-based electrochemical sensors for wearable applications have attracted substantial interest due to their non-invasive nature, compact design, and ability to provide real-time data. Remarkable advancements have been made in integrating these devices into flexible platforms. While thin-film polymer substrates are frequently employed for their durability, the prolonged buildup of sweat on such materials can disrupt consistent sensing performance and adversely affect skin comfort over extended periods. Therefore, investigating lightweight, comfortable, and breathable base materials for constructing working electrodes is essential for producing flexible and breathable sweat electrochemical sensors. In this study, nylon fabric was chosen as the base material for constructing the working electrode. The electrode is prepared using a straightforward printing process, incorporating Ti3C2TX MXene/polyaniline and methylene blue as modification materials in the electronic intermediary layer. The synergistic effect of the modified layer and the multi-level structure of the current collector enhances the electrochemical kinetics on the electrode surface, improves electron transmission efficiency, and enables the nylon fabric-based electrode to accurately and selectively measure glucose concentration in sweat. It exhibits a wide linear range (0.04~3.08 mM), high sensitivity (3.11 μA·mM−1), strong anti-interference capabilities, and high stability. This system can monitor glucose levels and trends in sweat, facilitating the assessment of daily sugar intake for personal health management. Full article
(This article belongs to the Section Biosensor and Bioelectronic Devices)
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43 pages, 3473 KiB  
Review
Biochips on the Move: Emerging Trends in Wearable and Implantable Lab-on-Chip Health Monitors
by Nikolay L. Kazanskiy, Pavel A. Khorin and Svetlana N. Khonina
Electronics 2025, 14(16), 3224; https://doi.org/10.3390/electronics14163224 - 14 Aug 2025
Viewed by 527
Abstract
Wearable and implantable Lab-on-Chip (LoC) biosensors are revolutionizing healthcare by enabling continuous, real-time monitoring of physiological and biochemical parameters in non-clinical settings. These miniaturized platforms integrate sample handling, signal transduction, and data processing on a single chip, facilitating early disease detection, personalized treatment, [...] Read more.
Wearable and implantable Lab-on-Chip (LoC) biosensors are revolutionizing healthcare by enabling continuous, real-time monitoring of physiological and biochemical parameters in non-clinical settings. These miniaturized platforms integrate sample handling, signal transduction, and data processing on a single chip, facilitating early disease detection, personalized treatment, and preventive care. This review comprehensively explores recent advancements in LoC biosensing technologies, emphasizing their application in skin-mounted patches, smart textiles, and implantable devices. Key innovations in biocompatible materials, nanostructured transducers, and flexible substrates have enabled seamless integration with the human body, while fabrication techniques such as soft lithography, 3D printing, and MEMS have accelerated development. The incorporation of nanomaterials significantly enhances sensitivity and specificity, supporting multiplexed and multi-modal sensing. We examine critical application domains, including glucose monitoring, cardiovascular diagnostics, and neurophysiological assessment. Design considerations related to biocompatibility, power management, data connectivity, and long-term stability are also discussed. Despite promising outcomes, challenges such as biofouling, signal drift, regulatory hurdles, and public acceptance remain. Future directions focus on autonomous systems powered by AI, hybrid wearable–implantable platforms, and wireless energy harvesting. This review highlights the transformative potential of LoC biosensors in shaping the future of smart, patient-centered healthcare through continuous, minimally invasive monitoring. Full article
(This article belongs to the Special Issue Lab-on-Chip Biosensors)
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64 pages, 20332 KiB  
Review
Reviewing a Decade of Structural Health Monitoring in Footbridges: Advances, Challenges, and Future Directions
by JP Liew, Maria Rashidi, Khoa Le, Ali Matin Nazar and Ehsan Sorooshnia
Remote Sens. 2025, 17(16), 2807; https://doi.org/10.3390/rs17162807 - 13 Aug 2025
Viewed by 186
Abstract
Aging infrastructure is a growing concern worldwide, with many bridges exceeding 50 years of service, prompting questions about their structural integrity. Over the past decade, the deterioration of bridges has driven extensive research into Structural Health Monitoring (SHM), a tool for early detection [...] Read more.
Aging infrastructure is a growing concern worldwide, with many bridges exceeding 50 years of service, prompting questions about their structural integrity. Over the past decade, the deterioration of bridges has driven extensive research into Structural Health Monitoring (SHM), a tool for early detection of structural deterioration, with particular emphasis on remote-sensing technologies. This review combines a scientometric analysis and a state-of-the-art review to assess recent advancements in the field. From a dataset of 702 publications (2014–2024), 171 relevant papers were analyzed, covering key SHM aspects including sensing devices, data acquisition, processing, damage detection, and reporting. Results show a 433% increase in publications, with the United States leading in output (28.65%), and Glisic, B., with collaborators forming the largest research cluster (11.7%). Accelerometers are the most commonly used sensors (50.88%), and data processing dominates the research focus (50.29%). Key challenges identified include cost (noted in 17.5% of studies), data corruption, and WSN limitations, particularly energy supply. Trends show a notable growth in AI applications (400%), and increasing interest in low-cost, crowdsource-based SHM using smartphones, MEMS, and cameras. These findings highlight both progress and future opportunities in SHM of footbridges. Full article
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