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Search Results (347)

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Keywords = self-healing models

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30 pages, 5412 KB  
Article
Rapid Recovery and Self-Healing Strategies for Power Distribution Systems Based on Dynamic Mesh Networks
by Ye Tian, Taiyu Gu, Rui Li, Jie Zhao, Fugen He, Yidong Zhu and Kejian Shi
Electronics 2026, 15(12), 2629; https://doi.org/10.3390/electronics15122629 - 14 Jun 2026
Viewed by 111
Abstract
With the increasing integration of distributed energy sources, fault restoration in power distribution systems faces challenges in terms of real-time performance and adaptability. To effectively manage the uncertainty and volatility of distributed generation, this paper proposes a rapid self-healing strategy based on a [...] Read more.
With the increasing integration of distributed energy sources, fault restoration in power distribution systems faces challenges in terms of real-time performance and adaptability. To effectively manage the uncertainty and volatility of distributed generation, this paper proposes a rapid self-healing strategy based on a dynamic operational grid. By enabling real-time topological reconfiguration and utilizing adaptive resource allocation, the proposed method accommodates the inherent fluctuations of distributed energy sources. First, a dynamic grid weighted graph theory model is constructed, and an emergency control strategy combining particle preprocessing and stepwise optimization is designed to achieve rapid fault response. Then, a “primary-secondary” two-tier restoration mechanism is established: the primary layer integrates the Floyd algorithm with optimized adaptive dynamic programming to achieve millisecond-level restoration of critical loads; the secondary layer employs an improved particle swarm algorithm incorporating Lévy flight perturbations and adaptive weighting to maximize the restoration of general loads. Simulations on a 56-node system demonstrate that this method achieves 100% restoration of critical loads under various fault scenarios. Even under extreme conditions, it can restore 90.88% of secondary loads and 44.63% of tertiary loads, forming a self-healing system characterized by “second-level detection and minute-level restoration,” thereby significantly enhancing system resilience. Full article
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32 pages, 4090 KB  
Article
Reinforcement Learning-Enhanced Large Language Models for Automated Modeling of Nuclear Thermal-Hydraulic Systems: A Plan-and-Act Agent Framework
by Luo Jun, Xiong Yan, Jing-Chen Lin and Da-Zhi Zhang
Appl. Sci. 2026, 16(12), 5885; https://doi.org/10.3390/app16125885 - 11 Jun 2026
Viewed by 201
Abstract
Automating system-level nuclear thermal-hydraulic (T-H) model construction remains challenging because platform-specific API syntax, graph connectivity, parameter dependency ordering, and solver admissibility must be satisfied simultaneously. This study develops a closed-loop modeling framework on the SAFRI platform by combining supervised fine-tuning (SFT), a Plan-and-Act [...] Read more.
Automating system-level nuclear thermal-hydraulic (T-H) model construction remains challenging because platform-specific API syntax, graph connectivity, parameter dependency ordering, and solver admissibility must be satisfied simultaneously. This study develops a closed-loop modeling framework on the SAFRI platform by combining supervised fine-tuning (SFT), a Plan-and-Act agent with retrieval-grounded parameter completion, and reinforcement learning based on group relative policy optimization (GRPO). The SFT stage uses a 6003-record domain corpus derived from expert-authored or expert-verified SAFRI modeling exemplars, while system-level generalization is evaluated on a held-out 50-case in-house evaluation set separated at the case-template level. At the component level, LoRA-adapted Qwen3-8B achieves 100% code accuracy, compared with 50% for zero-shot and 74% for one-shot prompting. At the system level, the SFT agent attains a 100% syntax success rate (SSR), 90% topology success rate (TSR), and 72.4% physical convergence rate (PCR), showing that local API correctness is insufficient for solver-valid model assembly. After GRPO training with schema, topology, physics, and sequence rewards, the full SAFRI-SFT-RL agent reaches a 100% SSR, 100% TSR, and 88.8% PCR on the in-house evaluation set, while an error self-healing loop resolves execution-time failures in an average of 2.3 corrective iterations. These results show that solver-grounded reinforcement learning is effective for closing the gap between syntactically correct script generation and physically convergent nuclear T-H model construction. Full article
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16 pages, 556 KB  
Article
The Perfection in Weakness Paradox (PIW): An Integrative Review of 2 Corinthians 12:9–10 and Third-Wave Psychotherapies
by Dae Hyun Yoon
Religions 2026, 17(6), 663; https://doi.org/10.3390/rel17060663 - 30 May 2026
Viewed by 259
Abstract
This study conceptualizes the theological principle declared by the Apostle Paul in 2 Corinthians 12:9–10—“My power is made perfect in weakness” (ἡ γὰρ δύναμίς μου ἐν ἀσθενείᾳ τελεῖται)—as the Perfection in Weakness Paradox (PIW) and examines it through an integrative lens with contemporary [...] Read more.
This study conceptualizes the theological principle declared by the Apostle Paul in 2 Corinthians 12:9–10—“My power is made perfect in weakness” (ἡ γὰρ δύναμίς μου ἐν ἀσθενείᾳ τελεῖται)—as the Perfection in Weakness Paradox (PIW) and examines it through an integrative lens with contemporary third-wave psychotherapies. A Reformed theological exegesis of 2 Corinthians 12:9–10 identifies two foundational axes: sola gratia (grace alone) and the acknowledgment of weakness. The core mechanisms of Self-Compassion (Neff), Acceptance and Commitment Therapy (ACT; Hayes), Post-Traumatic Growth (PTG; Tedeschi and Calhoun), and Rumination-Focused Cognitive Behavioral Therapy (RFCBT; Watkins) are then analyzed for their systematic parallels with PIW’s theological structure—acceptance of weakness, dissolution of self-criticism, meaning-making through suffering, and transformation of rumination. The evidence-based framework of Spiritual Psychiatry is applied to examine the relationship between spiritual practices and mental health from neuroscientific and clinical perspectives. The central thesis is bidirectional: (1) the revelatory principle of 2 Corinthians provides theological foundations for the healing mechanisms of third-wave psychotherapies, and (2) the empirical evidence of these psychotherapeutic theories offers convergent support for and strengthens the theological interpretation of 2 Corinthians in a contemporary clinical context. This integrative framework proposes a new model for interdisciplinary dialogue between theology and psychiatry and discusses implications for clinical practice. Full article
(This article belongs to the Special Issue The Roles of Religion and Spirituality in Healthcare)
24 pages, 10636 KB  
Article
A Scallop Active Peptide-Incorporated Carboxymethyl Chitosan/Oxidized Sodium Alginate Hydrogel for Accelerating Skin Wound Healing and Tissue Regeneration
by Lingfeng Kou, Huan Yang and Yunquan Zheng
Gels 2026, 12(6), 467; https://doi.org/10.3390/gels12060467 - 28 May 2026
Viewed by 263
Abstract
In this study, a novel composite hydrogel was developed based on oxidized sodium alginate (OSA), synthesized via sodium periodate oxidation, and incorporated into a carboxymethyl chitosan (CMCS) matrix. Scallop active peptides (SAPs), a marine-derived bioactive component with outstanding antioxidant and pro-regenerative activities, was [...] Read more.
In this study, a novel composite hydrogel was developed based on oxidized sodium alginate (OSA), synthesized via sodium periodate oxidation, and incorporated into a carboxymethyl chitosan (CMCS) matrix. Scallop active peptides (SAPs), a marine-derived bioactive component with outstanding antioxidant and pro-regenerative activities, was introduced to endow the hydrogel with enhanced biological functions, which is of great significance for breaking the functional limitations of traditional single-component hydrogels. The construction of a dynamic covalent network, driven by the Schiff base reaction, was confirmed through structural characterization using FT-IR and 1H-NMR. The hydrogel exhibited favorable physicochemical properties, including shear-thinning behavior, significant self-healing capability, and a uniform porous microstructure that effectively mimics the extracellular matrix (ECM). In vitro evaluations revealed excellent biocompatibility and potent pro-angiogenic potential, as evidenced by enhanced HUVEC migration and tube formation. In a rat model of full-thickness skin wounds, the CMCS/OSA/SAPs hydrogel significantly accelerated wound closure and promoted re-epithelialization and organized collagen deposition. Furthermore, immunohistochemical analysis confirmed upregulated VEGF and α-SMA expression, alongside reduced inflammatory levels (decreased iNOS), indicating potent tissue-regenerative and immunomodulatory functions. Overall, this work presents a multifunctional hydrogel system that integrates antioxidant, anti-inflammatory, and tissue-regenerative properties, offering a promising strategy for deep-wound healing. This study highlights the significant potential of marine-derived bioactive proteins/peptides in the development of advanced biomedical materials. Full article
(This article belongs to the Special Issue Polysaccharide-Based Gels)
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17 pages, 1520 KB  
Article
A Time-Entangled Self-Reconstructing Framework for Fault Tolerance in Distributed Real-Time Systems
by Nodirbek Yusupbekov, Shukhrat Gulyamov, Ulugbek Mukhamedkhanov, Dilshod Mirzaev, Barno Yeshmatova, Nasiba Khojieva and Shakhnoza Muksimova
Electronics 2026, 15(11), 2277; https://doi.org/10.3390/electronics15112277 - 25 May 2026
Viewed by 230
Abstract
Fault tolerance in distributed real-time systems has, up till now, relied on static redundancy, replication, or predictive mechanisms, which introduce latency, resource overhead, and inadaptability under dynamic failure conditions. This paper presents Chrono Weave (CW) as a revolutionary new idea that describes how [...] Read more.
Fault tolerance in distributed real-time systems has, up till now, relied on static redundancy, replication, or predictive mechanisms, which introduce latency, resource overhead, and inadaptability under dynamic failure conditions. This paper presents Chrono Weave (CW) as a revolutionary new idea that describes how a system is working as a flow of a time-ordered field of states, so that even if the system is broken, it can recover without explicit redundancy or replication. CW does not replicate computation but rather encodes system evolution into temporally entangled microstates; therefore, recovery is made possible through deterministic temporal interpolation. The Temporal Consistency Field (TCF), a new concept, is presented to measure system integrity over time, enabling fault localization and instant reconstruction. The new system does not require standby replicas, and recovery is achieved just by way of using temporal coherence that is inherent. From a theoretical viewpoint, it is shown that CW can reduce recovery latency asymptotically towards zero as long as the drift is bounded. From the perspective of distributed control, simulation experiments have still managed to show great recovery speed and system reliability improvements over the traditional ones. This paper opens fault-tolerant computing to a new mode of operation where instead of being based on redundancies, time-structured, self-healing systems are used. Full article
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25 pages, 4687 KB  
Article
Finite-Element Analysis of the Quasi-Static Response of Concrete Specimens Containing Polymeric Self-Healing Microcapsules
by Todor Zhelyazov
Polymers 2026, 18(11), 1289; https://doi.org/10.3390/polym18111289 - 24 May 2026
Viewed by 328
Abstract
Healing agent encapsulated in polymeric microcapsules has proven its ability to seal surface and internal cracks. Focused on mitigating the negative impact of capsules on the properties of fresh cement paste and hardened cementitious matrix, uncertainties in self-healing triggering, and poor control of [...] Read more.
Healing agent encapsulated in polymeric microcapsules has proven its ability to seal surface and internal cracks. Focused on mitigating the negative impact of capsules on the properties of fresh cement paste and hardened cementitious matrix, uncertainties in self-healing triggering, and poor control of the released quantity, researchers report technological improvements in predominantly experimental studies. However, practical applications will necessitate lightweight models that capture all the characteristics of practical importance. Analysis of the scientific literature reveals the lack of such models adapted for cementitious composites. In this paper, a model rooted in continuum damage mechanics, tuned based on empirical data, is used in the finite element analysis of concrete specimens containing polymer self-healing microcapsules to quantify self-healing efficiency and local damage-healing behavior. The predicted increase in the self-healing rate is more pronounced for specimens subjected to compression compared to that for elements subjected to four-point bending. Thus, for a 20% increase in healing efficiency, strength recovery in compression increases from 18.5% to 32% for C25 and C30, respectively, whereas the corresponding values for tension in the tension-be-flexure setup are 3.5% and 5.3%. Full article
(This article belongs to the Special Issue Application of Polymers in Cementitious Materials)
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21 pages, 13187 KB  
Article
Natural-Origin Bioadhesive Injectable Hydrogels Composed of Polyphenol and Chitosan with Antibacterial Activity for Wound Healing
by Hongyu Zheng, Shikui Wu, Yujie Liu, Yuzhu Zhang, Yushu Xing, Jianye Wang, Xin Yue, Lijun Sun, Xiao Li, Ying Zhang, Jiannan Ma, Xiaoli Du, Yan Xue, Juan Yu, Huiwen Zhang and Huanyun Wang
Gels 2026, 12(5), 448; https://doi.org/10.3390/gels12050448 - 20 May 2026
Viewed by 409
Abstract
This study aimed to develop antibacterial polyphenol–chitosan hydrogel dressings and, more importantly, to compare how three structurally distinct low-cost natural polyphenols—protocatechuic acid (PCA), gallic acid (GA), and tannic acid (TA)—regulate hydrogel performance within the same chitosan platform. PCA, GA, and TA were incorporated [...] Read more.
This study aimed to develop antibacterial polyphenol–chitosan hydrogel dressings and, more importantly, to compare how three structurally distinct low-cost natural polyphenols—protocatechuic acid (PCA), gallic acid (GA), and tannic acid (TA)—regulate hydrogel performance within the same chitosan platform. PCA, GA, and TA were incorporated into chitosan to obtain the corresponding hydrogels, denoted CS-PCA, CS-GA, and CS-TA. Scanning electron microscopy confirmed that all formulations possessed a three-dimensional porous network. Rheological characterization revealed favorable viscoelastic behavior for all polyphenol-containing hydrogels, with CS-TA showing the highest mechanical strength in the present system. The hydrogels also exhibited pH-responsive swelling, good tissue adhesion, self-healing ability, and injectability. In vitro antibacterial assays demonstrated activity against both Gram-positive and Gram-negative microorganisms, with CS-TA showing the most favorable overall antibacterial performance under the tested conditions. In a rat full-thickness wound model, hydrogel treatment accelerated wound closure, while H&E staining indicated enhanced granulation tissue formation, collagen deposition, and reduced inflammatory cell infiltration. Collectively, these findings support the use of polyphenol–chitosan composite hydrogels as promising wound-dressing candidates and highlight the value of a side-by-side comparison of PCA, GA, and TA for understanding structure–property–function relationships in this class of materials. Full article
(This article belongs to the Section Gel Chemistry and Physics)
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19 pages, 479 KB  
Article
Unrealised Divine Healing Expectations in Australian Pentecostalism
by Christopher David Cat
Religions 2026, 17(5), 582; https://doi.org/10.3390/rel17050582 - 12 May 2026
Viewed by 1340
Abstract
Despite common Pentecostal rhetoric positioning divine healing as normative and imminent, it remains rare, unpredictable, and temporary. This disconnect creates substantial pastoral and psychological challenges for Pentecostals experiencing chronic disease. Drawing on Pentecostal history, theology, and Pargament’s psychology of religion and coping, this [...] Read more.
Despite common Pentecostal rhetoric positioning divine healing as normative and imminent, it remains rare, unpredictable, and temporary. This disconnect creates substantial pastoral and psychological challenges for Pentecostals experiencing chronic disease. Drawing on Pentecostal history, theology, and Pargament’s psychology of religion and coping, this paper employs practical theology to investigate contemporary Australian healing praxis. 17 pastoral caregivers and 8 care receivers experiencing chronic diseases were interviewed to contrast expectations and actual experiences of healing ministry. The findings reveal that, even when healing does not manifest, caregivers maintain high healing expectations founded on atonement theology and faith-motivated prayer, and their praxis tends to blame recipients for insufficient faith or unconfessed sin, appeals to God’s mysterious sovereignty, and resists re-evaluation. Using Pargament’s means-and-ends model, the analysis demonstrates that inflexible praxis hindered coping, creating guilt, self-doubt, and religious trauma. While caregivers demonstrated genuine concern and practical support, care receivers felt pressured to hide ongoing struggles and privately developed acceptance strategies. Disconnectedly, caregivers remain confused by the expectation-experience gap while receivers quietly embrace suffering as God’s will. This paper invites Pentecostals toward greater self-awareness, recommending reforms: recognising faith and suffering as compatible, honest acknowledgment of healing rarity, expanded engagement with coping resources, and person-centred care. Full article
(This article belongs to the Special Issue Religion, Ritual, and Healing—2nd Edition)
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34 pages, 15443 KB  
Review
Plasma-Sprayed YSZ Thermal Barrier Coatings: Process–Microstructure–Degradation Relationships
by Xiaogang Ding, Ruilin Zeng, Shequan Wang, Ninghua Long, Chao Yin, Kongming Yan, Qun Wang and Chidambaram Seshadri Ramachandran
Coatings 2026, 16(5), 562; https://doi.org/10.3390/coatings16050562 - 8 May 2026
Viewed by 1235
Abstract
Plasma-sprayed yttria-stabilized zirconia (YSZ) coatings are critical to enhancing the performance of thermal barrier coatings in gas turbines and aero-engines; however, their service life is significantly constrained by microstructural evolution and multi-mechanism coupling effects. Focusing on plasma spraying process routes (atmospheric plasma spraying, [...] Read more.
Plasma-sprayed yttria-stabilized zirconia (YSZ) coatings are critical to enhancing the performance of thermal barrier coatings in gas turbines and aero-engines; however, their service life is significantly constrained by microstructural evolution and multi-mechanism coupling effects. Focusing on plasma spraying process routes (atmospheric plasma spraying, APS; suspension plasma spraying/solution precursor plasma spraying, SPS/SPPS; low-pressure plasma spraying, LPPS) and key process parameters as primary input variables, this review systematically analyzes their regulatory roles in microstructural characteristics such as porosity and crack density. Available studies indicate that distinct process routes give rise to pronounced structural differences: the porosity of APS coatings is 10%–20%, that of SPS/SPPS coatings is 15%–30%, and that of LPPS coatings is 1%–8%. After thermal exposure above 1100 °C, the porosity decreases to 6%–12%, 8%–18%, and 0.5%–3%, respectively, while the thermal conductivity increases to a maximum of approximately 2.5 W·m−1·K−1 and the Young’s modulus rises to 60–220 GPa. Further analysis reveals that mechanisms such as sintering densification, phase destabilization, thermally grown oxide (TGO) interfacial stress accumulation, and calcium–magnesium–alumino-silicate (CMAS) infiltration exert coupled amplification effects through microstructural evolution, thereby accelerating coating failure. On this basis, emerging regulation strategies are evaluated: the CMAS penetration depth of high-entropy oxides at 1300 °C for 5 h is only about 1/7 that of conventional YSZ, the thermal cycling life of self-healing coatings is enhanced by up to 4.2 times, and the crack density is reduced by approximately 35%. Finally, it is proposed that a quantitative prediction model integrating “structural parameters–evolution kinetics–service life” should be established, and that anti-sintering design, gradient structures, and functionalized systems be combined to enable the transition of YSZ coatings from empirical optimization to predictable design. Full article
(This article belongs to the Section Ceramic Coatings and Engineering Technology)
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28 pages, 357 KB  
Review
Review on Clustering and Aggregation Modeling Methods for Distribution Networks with Large-Scale DER Integration
by Ye Yang, Yetong Luo and Jingrui Zhang
Energies 2026, 19(9), 2205; https://doi.org/10.3390/en19092205 - 2 May 2026
Viewed by 522
Abstract
As the global response to climate change and energy crises accelerates, the large-scale integration of heterogeneous distributed energy resources (DERs) is rapidly transforming traditional passive distribution networks into active distribution networks. However, the massive quantity and high stochasticity of these underlying devices trigger [...] Read more.
As the global response to climate change and energy crises accelerates, the large-scale integration of heterogeneous distributed energy resources (DERs) is rapidly transforming traditional passive distribution networks into active distribution networks. However, the massive quantity and high stochasticity of these underlying devices trigger a severe “curse of dimensionality,” creating significant computational and communication bottlenecks for coordinated system dispatch. To overcome these challenges, the “clustering followed by equivalence” aggregation modeling paradigm has emerged as a critical technical pathway. This paper reviews the state-of-the-art clustering and aggregation methodologies for distribution networks with high DER penetration. The review begins by synthesizing multi-dimensional feature extraction techniques and cutting-edge clustering algorithms that establish the foundation for dimensionality reduction. It then delves into refined aggregation models tailored to heterogeneous resources, including dynamic data-driven equivalence for renewable generation, Minkowski sum-based boundary approximations for energy storage, and thermodynamic alongside Markov chain mapping methods for flexible loads. Building upon these models, the paper comprehensively discusses the practical applications of generalized aggregators, such as microgrids and virtual power plants, in feasible region error evaluation, coordinated network control, multi-agent market games, and privacy-preserving architectures. Finally, the review outlines future research trajectories, emphasizing hybrid data-model-driven architectures for real-time dispatch, distributionally robust optimization (DRO) for enhancing grid resilience and self-healing, and decentralized trading ecosystems to ensure equitable system-level surplus allocation. This review aims to provide a systematic theoretical reference for the coordinated management and aggregated trading of flexibility resources in novel power systems. Full article
16 pages, 1673 KB  
Review
Research Progress on Nano-TiO2 Photocatalytic Degradation of Automobile Exhaust
by Yang Yang, Sitong Bie, Haiping Liu, Jie Li, Xiaoxue Zhang and Zijun Zhang
Molecules 2026, 31(9), 1439; https://doi.org/10.3390/molecules31091439 - 27 Apr 2026
Viewed by 497
Abstract
Nano-TiO2 is widely used in many industrial fields due to its unique physical and chemical properties. In recent years, it has become a core material in the research of road engineering for degrading automobile exhaust. Under ultraviolet irradiation, it can excite electron-hole [...] Read more.
Nano-TiO2 is widely used in many industrial fields due to its unique physical and chemical properties. In recent years, it has become a core material in the research of road engineering for degrading automobile exhaust. Under ultraviolet irradiation, it can excite electron-hole pairs and use its strong redox capacity to decompose automobile exhaust and improve air quality. From the perspectives of materials, performance and engineering application, this paper briefly describes the structure and physicochemical properties of nano-TiO2, reviews the recent research progress of nano-TiO2 in the photocatalytic degradation of automobile exhaust, systematically compares the effects of various strategies such as incorporation methods and modified materials on exhaust degradation efficiency, and conducts a quantitative analysis of performance differences. It is pointed out that insufficient road durability, poor compatibility with pavement materials and limited adaptability to unconventional environments are the main current problems and challenges in this research direction. The future development directions such as developing self-healing composite systems and constructing machine learning prediction models are also prospected. Full article
(This article belongs to the Special Issue Synthesis, Reaction Mechanism and Application of Photocatalysts)
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28 pages, 3651 KB  
Article
Ready-to-Use or Ready-to-Adapt: Can the Self-Healing Potential of Bacillus licheniformis Be Modified?
by Luka Mejić, Olja Šovljanski, Milada Pezo, Lato Pezo, Tiana Milović and Ana Tomić
Bioengineering 2026, 13(5), 495; https://doi.org/10.3390/bioengineering13050495 - 24 Apr 2026
Cited by 1 | Viewed by 1180
Abstract
In recent years, bacteria-based self-healing has emerged as a promising bioengineering strategy to address the self-repair of cracks in cement-based materials, which represent one of the persistent durability challenges. This approach relies on microbiologically induced calcium carbonate (CaCO3) precipitation (MICP), in [...] Read more.
In recent years, bacteria-based self-healing has emerged as a promising bioengineering strategy to address the self-repair of cracks in cement-based materials, which represent one of the persistent durability challenges. This approach relies on microbiologically induced calcium carbonate (CaCO3) precipitation (MICP), in which metabolically active bacteria promote CaCO3 formation of crystals that can heal cracks and restore material integrity. This study compares the self-healing potential of a natural (N-) alkaline soil Bacillus licheniformis strain with a UV-strain (phenotypic mutant) generated through controlled UV exposure followed by adaptive evolution. Both strains were evaluated under conditions relevant to cementitious environments. The UV-strain exhibited enhanced ureolytic performance, reaching urease activity of 0.32 U/mg compared to 0.24 U/mg in the N-strain. This translated into improved biomineralization, with CaCO3 precipitation reaching 2.37 mg versus 2.23 mg/100 mL in the N-strain. Additionally, the UV-strain showed increased cell hydrophobicity and aggregation, indicating improved nucleation potential and surface-mediated mineral deposition. Multivariate analysis confirmed strong correlations between ureolytic metabolism, alkalization, and mineral formation, while artificial neural network (ANN) modeling (MLP 6-10-14) successfully predicted biomineralization-related parameters with high accuracy (R2 > 0.90 for urease activity, NH4+, ΔpH, and CaCO3). The results demonstrate that UV-induced phenotypic adaptation can enhance biomineralization efficiency with minor trade-offs in physiological robustness. For the first time, that controlled UV-induced phenotypic adaptation can be used as a targeted strategy to enhance biomineralization efficiency in B. licheniformis, while maintaining functional stability under cement-relevant conditions. These findings provide a novel framework for tailoring bacterial performance in self-healing systems for construction biotechnology. Full article
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20 pages, 13493 KB  
Article
Modeling of Basalt Fiber Self-Healing Processes in Aggressive Alkaline Environment of OPC Concrete: The Impact of Metakaolin
by Pavlo Kryvenko, Igor Rudenko, Oleksandr Gelevera and Oleksandr Konstantynovskyi
Fibers 2026, 14(5), 45; https://doi.org/10.3390/fib14050045 - 23 Apr 2026
Viewed by 452
Abstract
The paper deals with the concept of how to regulate structure formation in the interfacial transition zone (ITZ) between the Ordinary Portland Cement (OPC) matrix and basalt to ensure the durability of basalt fiber-reinforced concretes. It has been demonstrated that the alkali–silica reaction [...] Read more.
The paper deals with the concept of how to regulate structure formation in the interfacial transition zone (ITZ) between the Ordinary Portland Cement (OPC) matrix and basalt to ensure the durability of basalt fiber-reinforced concretes. It has been demonstrated that the alkali–silica reaction (ASR) can be transformed from a destructive (negative) process into a constructive one in OPC concrete through activation by sodium water glass combined with the incorporation of an Al2O3-containing additive, namely metakaolin. Alkaline activation increased the compressive strength of OPC basalt fiber-reinforced concrete by 1.6–1.9 times. The formation of stable zeolite-like hydration products within the Na2O-CaO-Al2O3-SiO2-H2O system promoted self-healing of the ITZ. This resulted in a 5.6-fold increase in ITZ microhardness compared to the cement matrix, as well as transforming expansion into shrinkage of concrete with a final value of 0.01 mm/m after 360 days. The structure-forming processes in the ITZ ensured a 1.14-fold increase in the compressive strength of 180-day alkali-activated OPC basalt fiber-reinforced concrete compared to its 30-day strength, in contrast to a 0.92-fold decrease in the strength of the non-modified OPC analog under conditions accelerating the development of ASR. Full article
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22 pages, 3899 KB  
Article
A Multifunctional Shape-Adaptive Bilayer Hydrogel for Acute Hemostasis, Wound Repair, and Insect Bite Defense
by Rongyan He, Wenhui Yan, Qiuyu Cao, Chun Zhang, Yuxiu Ye, Yao Chen, Shaoxian Wu, Fei Han and Sulan Luo
Gels 2026, 12(4), 347; https://doi.org/10.3390/gels12040347 - 21 Apr 2026
Viewed by 865
Abstract
Fieldwork carries a high risk of irregular, non-compressible traumatic wounds, which often initiate a vicious cycle of “traumatic bleeding-insect bite-secondary infection”. Conventional dressings cannot combine rapid hemostasis with physical protection against venomous insects, creating an urgent demand for multifunctional field trauma dressings. To [...] Read more.
Fieldwork carries a high risk of irregular, non-compressible traumatic wounds, which often initiate a vicious cycle of “traumatic bleeding-insect bite-secondary infection”. Conventional dressings cannot combine rapid hemostasis with physical protection against venomous insects, creating an urgent demand for multifunctional field trauma dressings. To solve this problem, this study developed a shape-adaptive bilayer hydrogel that concurrently provides rapid hemostasis, promotes wound repair, and acts as a robust physical barrier. The hydrogel adopts a layered design: the bottom layer (PPTY) achieves autogelation within 3 s upon blood contact, while the top armor protective layer (AP) withstands pressures up to 942 kPa. By incorporating chitosan and sodium citrate into the AP precursor solution, the hydrogel achieved in situ formation within 50 s and developed a stable self-renewing armor layer. The tightly bonded bilayer showed complementary functions. In rat models of femoral artery puncture and tail vein bleeding, PPTY-AP hydrogel significantly reduced blood loss and shortened hemostasis time. Moreover, the hydrogel demonstrated excellent tissue adhesion and moisture retention capacity, promoting full-thickness skin wound healing. This multifunctional, rapidly deployable hydrogel presents a promising solution for field trauma management and offers a new design paradigm for advanced wound dressings. Full article
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23 pages, 4757 KB  
Article
Autologous Chondrocyte Implantation on Polyethersulfone Scaffolds in a Rabbit Model of Grade III Lesions
by Maciej Płończak, Monika Wasyłeczko, Tomasz Jakutowicz, Andrzej Chwojnowski and Jarosław Czubak
Molecules 2026, 31(8), 1302; https://doi.org/10.3390/molecules31081302 - 16 Apr 2026
Viewed by 359
Abstract
Articular cartilage has a limited capacity for self-repair, and effective strategies for its regeneration remain a major clinical challenge. Full-thickness cartilage defects extending to the subchondral bone induce an enhanced inflammatory response and impair spontaneous healing. This study aimed to evaluate the regenerative [...] Read more.
Articular cartilage has a limited capacity for self-repair, and effective strategies for its regeneration remain a major clinical challenge. Full-thickness cartilage defects extending to the subchondral bone induce an enhanced inflammatory response and impair spontaneous healing. This study aimed to evaluate the regenerative potential of autologous chondrocyte transplantation using an insoluble polyethersulfone (PES) scaffold in a rabbit model of grade III articular cartilage lesions. Chondrocytes were isolated and expanded in vitro and subsequently seeded onto PES membranes. Sixty-two rabbit knees with defects extending to the subchondral bone were divided into three groups: group I received chondrocyte-seeded PES scaffolds (n = 25), group II received cell-free PES scaffolds (n = 25), and group III served as an untreated control (n = 12). Cartilage regeneration was evaluated macroscopically and histologically over 52 weeks. In addition, the chondrogenic differentiation potential of cells cultured on PES scaffolds was assessed. This study extends our previous investigations of PES scaffolds in grade IV cartilage defects to a clinically relevant grade III lesion model, enabling evaluation of regenerative outcomes at an earlier stage of cartilage degeneration. The results demonstrated superior tissue regeneration in defects treated with chondrocyte-seeded PES scaffolds compared to both control groups. These findings indicate that synthetic PES scaffolds support cartilage repair and represent a promising biomaterial for the development of cell-based therapies in articular cartilage regeneration. Full article
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