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17 pages, 2424 KiB  
Article
Abundance, Diet and Foraging of Galápagos Barn Owls (Tyto furcata punctatissima)
by Hermann Wagner, Sebastian Cruz, Gustavo Jiménez-Uzcátegui, Katherine Albán, Galo Quezada and Paolo Piedrahita
Animals 2025, 15(15), 2283; https://doi.org/10.3390/ani15152283 - 5 Aug 2025
Viewed by 43
Abstract
We studied Galápagos barn owls on Santa Cruz Island in the Galápagos Archipelago. We collected and analyzed pellets to determine diet composition. Barn-owl diet consisted—in terms of biomass—of ~89% rodents and ~10% insects. Bird remains occurred in 1% of the pellets. Foraging was [...] Read more.
We studied Galápagos barn owls on Santa Cruz Island in the Galápagos Archipelago. We collected and analyzed pellets to determine diet composition. Barn-owl diet consisted—in terms of biomass—of ~89% rodents and ~10% insects. Bird remains occurred in 1% of the pellets. Foraging was studied with data loggers, a method not previously applied to the study of Galápagos barn owls. Owls rested during the day in natural and human-built roosts such as lava holes, trees, or huts. Night-time foraging was characterized by periods during which the bird moved and periods during which the bird stayed within one place, with the latter amounting to ~56% of the time away from the day roost. Birds began foraging shortly after sunset and returned to their day roost before sunrise. The duration of foraging was approximately 11 h per night. Foraging areas were small (median value: 0.28 km2). Although our data demonstrate a continued presence of the subspecies, we regard the situation for this subspecies as labile, as multiple threats, such as road kills, poisoning, and intentional killing by farmers, have increased recently, and suggest the development of a management plan to improve its conservation. Full article
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6 pages, 876 KiB  
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An Exceptionally Rare Predation on a Chameleon Species (Squamata: Chamaeleonidae) by a Eurasian Eagle-Owl (Aves: Strigidae)
by Apostolos Christopoulos, Luca Cornacchia, Christos Kotselis and Yiannis G. Zevgolis
Diversity 2025, 17(5), 333; https://doi.org/10.3390/d17050333 - 4 May 2025
Viewed by 1169
Abstract
The Eurasian eagle-owl (Bubo bubo) is a large, generalist predator widely distributed across Eurasia, including mainland Greece, where it occupies a broad range of habitats. Its diet is known to consist primarily of mammals and birds, with reptiles occasionally included. However, [...] Read more.
The Eurasian eagle-owl (Bubo bubo) is a large, generalist predator widely distributed across Eurasia, including mainland Greece, where it occupies a broad range of habitats. Its diet is known to consist primarily of mammals and birds, with reptiles occasionally included. However, to date, chameleons have not been documented among its prey. Here, we report the first confirmed case of B. bubo preying on an African chameleon (Chamaeleo africanus) in the western Peloponnese of southern Greece—a region where the two species occur in limited sympatry. C. africanus, native to North Africa and introduced to Greece since antiquity, is a diurnal, slow-moving, arboreal lizard with highly cryptic behavior and specialized anti-predator strategies. Despite these traits, our observation highlights its potential vulnerability to nocturnal avian predators. This rare predation event offers novel insights into the trophic ecology of B. bubo and raises important considerations for the conservation of C. africanus, a species listed as Critically Endangered in Greece and increasingly threatened by habitat loss, illegal collection, and road traffic collisions. Full article
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3 pages, 157 KiB  
Editorial
The Gluten-Free Diet: The Road Ahead
by Carlo Catassi and Fernando Gabriel Chirdo
Nutrients 2025, 17(7), 1226; https://doi.org/10.3390/nu17071226 - 31 Mar 2025
Cited by 1 | Viewed by 807
Abstract
The gluten-free diet (GFD) is the resolutive and safe treatment of celiac disease (CeD), i [...] Full article
(This article belongs to the Special Issue Recent Advances in Gluten-Free Diet and Celiac Disease)
13 pages, 1326 KiB  
Article
Assessing Energy Availability and Glucose Dynamics in Adolescent Cyclists: Implications for Nutritional Interventions During the Competitive Season
by Matteo Tarocchi, Alessio Pellegrino, Kristina Skroce, Andrea Zignoli, Letizia Clara Cavadini, Chiara Bodini, Giuditta Pagliai, Loira Toncelli, Laura Stefani, Simone Vanni, Maria Boddi, Alessandra Modesti and Pietro Amedeo Modesti
Nutrients 2024, 16(22), 3824; https://doi.org/10.3390/nu16223824 - 7 Nov 2024
Viewed by 1868
Abstract
Background: The risk of developing a state of low energy availability (LEA) (<30 kcals/kg free-fat mass) in endurance athletes is known and recommendations for nutrition are available. However, information on male adolescent cyclists and the influence of hot temperatures is limited. Objectives: The [...] Read more.
Background: The risk of developing a state of low energy availability (LEA) (<30 kcals/kg free-fat mass) in endurance athletes is known and recommendations for nutrition are available. However, information on male adolescent cyclists and the influence of hot temperatures is limited. Objectives: The aim of this study was to investigate the impact on energy availability of two 4-day nutritional intervention strategies: (1) supplementary carbohydrate (CHO) intake during exercise and (2) designing and implementing individual nutritional interventions. Methods: Each intervention was preceded by a 4-day basal assessment. Eight competitive male junior road cyclists (aged 16–17 years) were investigated using a 4-day diet and activity records, alongside bioelectric impedance analysis. Their real-time power output, interstitial glucose, and temperature were recorded via sensors and a bike computer. Their energy intake (EI) was estimated from daily, self-reported food diaries. Results: Overall, 100% and 71% of the cyclists were in a state of LEA during the baseline assessment of the supplementary CHO and nutritional interventions, respectively. LEA prevalence, not modified by supplementary CHO intake alone (from 100% to 87%, ns), was markedly reduced by the individual nutritional intervention (from 71% to 14%, p < 0.05). When considering all the data as a whole, LEA was positively influenced by the training load (OR 1.06; 95% Cl 1.03 to 1.09) and free-fat mass (OR 1.46; 1.04 to 2.04) and was negatively affected by EI (OR 0.994; 0.991 to 0.997). A hot environment (air temperature) failed to influence the LEA or glucose dynamics. Conclusions: the nutritional intervention, but not the supplementary CHO intake, markedly reduced the prevalence of LEA in adolescents, who often fail to match their energy expenditure with their energy intake during the competitive season. Nutritional education is essential for adolescent endurance cycling teams. Full article
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20 pages, 263 KiB  
Article
The Effects of Electrolytic Multivitamins and Neomycin on Antioxidant Capacity and Intestinal Damage in Transported Lambs
by Cui Xia, Chunhui Duan, Conghui Chen, Xinyu Yang, Yingjie Zhang, Yueqin Liu and Yuzhong Ma
Animals 2024, 14(6), 824; https://doi.org/10.3390/ani14060824 - 7 Mar 2024
Cited by 2 | Viewed by 1223
Abstract
Transport stress can cause damage to animals. In this experiment, 60 four-month-old lambs were randomly divided into three groups: CG (basal diet), EG (basal diet + 375 mg/d/lamb electrolytic multivitamin), and NG (basal diet + 200 mg/d/lamb neomycin). The results were as follows: [...] Read more.
Transport stress can cause damage to animals. In this experiment, 60 four-month-old lambs were randomly divided into three groups: CG (basal diet), EG (basal diet + 375 mg/d/lamb electrolytic multivitamin), and NG (basal diet + 200 mg/d/lamb neomycin). The results were as follows: during road transport, in all groups, the levels of SOD, T-AOC, and GSP-Px, and mRNA expressions of CAT, SOD, Nrf2, HO-1, and Bcl-2 in the jejunum and colon decreased (p < 0.01). However, mRNA expressions of Keap1, IL-1β, IL-2, IL-12, Bax, and Caspase3 in the jejunum and colon and the level of MDA increased (p < 0.01). The concentrations of IgA, IgG, and sIgA in the jejunum and colon also decreased (p < 0.01). In the EG and NG, the levels of SOD (p < 0.05) and T-AOC (p < 0.01) increased, and the level of MDA decreased (p < 0.01). However, in the jejunum, the levels of SOD and T-AOC, the concentrations of IgA and IgG, and mRNA expression of Bcl-2 increased (p < 0.05). mRNA expressions of IL-1, IL-2, and Caspase 3 (p < 0.05), and mRNA expression of IL-12 (p < 0.01) decreased. In the colon, SOD activity and the concentration of sIgA increased (p < 0.01). The level of MDA and mRNA expressions of IL-2 and Caspase 3 also decreased (p < 0.05). In the jejunum and colon, mRNA expression of SOD (p < 0.05) and mRNA expression of Nrf2 increased (p < 0.01). mRNA expression of Keap1 (p < 0.05) and Bax (p < 0.01) decreased. In summary, road transport can cause a decrease in antioxidant activity and immunity of lambs and an increase in oxidative damage. Electrolytic multivitamins and neomycin can improve immune function and potentially reduce oxidative damage to the jejunum and colon. Full article
(This article belongs to the Special Issue Animal Stress and Welfare During Transport and Slaughtering)
29 pages, 1504 KiB  
Review
Global Food Security and Sustainability Issues: The Road to 2030 from Nutrition and Sustainable Healthy Diets to Food Systems Change
by Theodoros Varzakas and Slim Smaoui
Foods 2024, 13(2), 306; https://doi.org/10.3390/foods13020306 - 18 Jan 2024
Cited by 60 | Viewed by 23422
Abstract
The accomplishment of food/nutrition security for all across sustainable food systems (SFS) is tied to the Sustainable Development Goals (SDGs). SFS is connected to all SDGs via the traditional framework of social inclusion, economic development, environmental safety, inclusivity, and the development of sustainable [...] Read more.
The accomplishment of food/nutrition security for all across sustainable food systems (SFS) is tied to the Sustainable Development Goals (SDGs). SFS is connected to all SDGs via the traditional framework of social inclusion, economic development, environmental safety, inclusivity, and the development of sustainable food systems. We suggest that, for the world to achieve sustainable development, a shift to SFS is necessary to guarantee food/nutrition security for all, while operating within planetary boundaries to protect ecosystems and adapt to and mitigate climate change. Therefore, there is a requirement for original approaches that implement systemic and more participatory methods to engage with a wider range of food system stakeholders. However, the lack of skills and tools regarding novel methodologies for food system transformation is a key obstacle to the deployment of such approaches in practice. In the first part of this review, a summary of some challenges that occur in the governance of food system transformation is given. Through a case study of plant-based proteins and their biological and chemical modification as diets shift towards alternative proteins, we demonstrate that resource-efficient food systems and food waste, through system transformation, are useful in understanding both (i) how food system transformation has ensued and (ii) how the required transformation is prohibited. Finally, we discuss the implications of food system transformation in terms of nutrition and sustainable healthy diets, which are needed to achieve changes in food safety systems in the future. The linkage of food and the environment is evident, focusing on nutrition and sustainable healthy diets. This cannot be accomplished without system change and research towards new foods and, more specifically, new proteins such as plant-based ones and their biological and chemical modification. Full article
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10 pages, 2473 KiB  
Article
Comparison of Estimated Wild Giant Anteater (Myrmecophaga tridactyla Linnaeus, 1758) Diets with Commercial Diets for Insectivores: Implications for Anteater Health
by Heidi Bissell, Mario H. Alves, Débora R. Yogui, Margarita Woc Colburn and Arnaud L. J. Desbiez
Animals 2023, 13(23), 3606; https://doi.org/10.3390/ani13233606 - 22 Nov 2023
Cited by 4 | Viewed by 4106
Abstract
Using the stomach contents of 24 wild road-killed giant anteaters as proxies for their diet, we found that estimated wild diets were much lower in calcium (about ten times less) and phosphorus compared with manufactured feeds commonly fed to anteaters under human care. [...] Read more.
Using the stomach contents of 24 wild road-killed giant anteaters as proxies for their diet, we found that estimated wild diets were much lower in calcium (about ten times less) and phosphorus compared with manufactured feeds commonly fed to anteaters under human care. Indicators of soil consumption, such as ash, iron, and manganese were higher in the stomach contents than in either wild termites or manufactured diets, likely due to high levels of soil ingestion during feeding in the wild. Protein and fat levels in insects, stomach contents, and commercial diets all met carnivore recommendations. Both giant anteaters and tamanduas in managed care often develop hypercalcemia, perhaps because these taxa have an enhanced ability to retain calcium allowing them to survive on such low calcium diets. Results from this study indicate that, for anteaters in managed care, it is important to keep dietary calcium and vitamins D and K within recommended levels to prevent nutritional diseases such as hyper- and hypocalcemia and vitamin K deficiency. Full article
(This article belongs to the Section Animal Nutrition)
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19 pages, 3120 KiB  
Article
The Long-Term Mortality Effects Associated with Exposure to Particles and NOx in the Malmö Diet and Cancer Cohort
by Henrik Olstrup, Erin Flanagan, Jan-Olov Persson, Ralf Rittner, Hanne Krage Carlsen, Leo Stockfelt, Yiyi Xu, Lars Rylander, Susanna Gustafsson, Mårten Spanne, Daniel Oudin Åström, Gunnar Engström and Anna Oudin
Toxics 2023, 11(11), 913; https://doi.org/10.3390/toxics11110913 - 7 Nov 2023
Cited by 4 | Viewed by 6026
Abstract
In this study, the long-term mortality effects associated with exposure to PM10 (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM2.5 (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), and [...] Read more.
In this study, the long-term mortality effects associated with exposure to PM10 (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM2.5 (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), and NOx (nitrogen oxides) were analyzed in a cohort in southern Sweden during the period from 1991 to 2016. Participants (those residing in Malmö, Sweden, born between 1923 and 1950) were randomly recruited from 1991 to 1996. At enrollment, 30,438 participants underwent a health screening, which consisted of questionnaires about lifestyle and diet, a clinical examination, and blood sampling. Mortality data were retrieved from the Swedish National Cause of Death Register. The modeled concentrations of PM10, PM2.5, BC, and NOx at the cohort participants’ home addresses were used to assess air pollution exposure. Cox proportional hazard models were used to estimate the associations between long-term exposure to PM10, PM2.5, BC, and NOx and the time until death among the participants during the period from 1991 to 2016. The hazard ratios (HRs) associated with an interquartile range (IQR) increase in each air pollutant were calculated based on the exposure lag windows of the same year (lag0), 1–5 years (lag1–5), and 6–10 years (lag6–10). Three models were used with varying adjustments for possible confounders including both single-pollutant estimates and two-pollutant estimates. With adjustments for all covariates, the HRs for PM10, PM2.5, BC, and NOx in the single-pollutant models at lag1–5 were 1.06 (95% CI: 1.02–1.11), 1.01 (95% CI: 0.95–1.08), 1.07 (95% CI: 1.04–1.11), and 1.11 (95% CI: 1.07–1.16) per IQR increase, respectively. The HRs, in most cases, decreased with the inclusion of a larger number of covariates in the models. The most robust associations were shown for NOx, with statistically significant positive HRs in all the models. An overall conclusion is that road traffic-related pollutants had a significant association with mortality in the cohort. Full article
(This article belongs to the Special Issue Ambient Air Pollution Exposure and Human Health)
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17 pages, 2525 KiB  
Review
All Roads Lead to the Gut: The Importance of the Microbiota and Diet in Migraine
by Eleonóra Spekker and Gábor Nagy-Grócz
Neurol. Int. 2023, 15(3), 1174-1190; https://doi.org/10.3390/neurolint15030073 - 13 Sep 2023
Cited by 8 | Viewed by 6187
Abstract
Migraine, a prevalent neurological condition and the third most common disease globally, places a significant economic burden on society. Despite extensive research efforts, the precise underlying mechanism of the disease remains incompletely comprehended. Nevertheless, it is established that the activation and sensitization of [...] Read more.
Migraine, a prevalent neurological condition and the third most common disease globally, places a significant economic burden on society. Despite extensive research efforts, the precise underlying mechanism of the disease remains incompletely comprehended. Nevertheless, it is established that the activation and sensitization of the trigeminal system are crucial during migraine attacks, and specific substances have been recognized for their distinct involvement in the pathomechanism of migraine. Recently, an expanding body of data indicates that migraine attacks can be prevented and treated through dietary means. It is important to highlight that the various diets available pose risks for patients without professional guidance. This comprehensive overview explores the connection between migraine, the gut microbiome, and gastrointestinal disorders. It provides insight into migraine-triggering foods, and discusses potential diets to help reduce the frequency and severity of migraine attacks. Additionally, it delves into the benefits of using pre- and probiotics as adjunctive therapy in migraine treatment. Full article
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23 pages, 2511 KiB  
Article
The Venom Composition of the Snake Tribe Philodryadini: ‘Omic’ Techniques Reveal Intergeneric Variability among South American Racers
by Emilly Campos Tioyama, Juan David Bayona-Serrano, José A. Portes-Junior, Pedro Gabriel Nachtigall, Vinicius Carius de Souza, Emidio Beraldo-Neto, Felipe Gobbi Grazziotin, Inácio L. M. Junqueira-de-Azevedo, Ana Maria Moura-da-Silva and Luciana Aparecida Freitas-de-Sousa
Toxins 2023, 15(7), 415; https://doi.org/10.3390/toxins15070415 - 27 Jun 2023
Cited by 8 | Viewed by 2754
Abstract
Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse group of rear-fanged snakes widespread in different ecological conditions, including habitats and diet. However, little is known about the composition and effects of their venoms despite their relevance [...] Read more.
Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse group of rear-fanged snakes widespread in different ecological conditions, including habitats and diet. However, little is known about the composition and effects of their venoms despite their relevance for understanding the evolution of these snakes or even their impact on the occasional cases of human envenoming. In this study, we integrated venom gland transcriptomics, venom proteomics and functional assays to characterize the venoms from eight species of the Philodryadini tribe, which includes the genus Philodryas, Chlorosoma and Xenoxybelis. The most abundant components identified in the venoms were snake venom metalloproteinases (SVMPs), cysteine-rich secretory proteins (CRISPs), C-type lectins (CTLs), snake endogenous matrix metalloproteinases type 9 (seMMP-9) and snake venom serinoproteinases (SVSPs). These protein families showed a variable expression profile in each genus. SVMPs were the most abundant components in Philodryas, while seMMP-9 and CRISPs were the most expressed in Chlorosoma and Xenoxybelis, respectively. Lineage-specific differences in venom composition were also observed among Philodryas species, whereas P. olfersii presented the highest amount of SVSPs and P. agassizii was the only species to express significant amounts of 3FTx. The variability observed in venom composition was confirmed by the venom functional assays. Philodryas species presented the highest SVMP activity, whereas Chlorosoma species showed higher levels of gelatin activity, which may correlate to the seMMP-9 enzymes. The variability observed in the composition of these venoms may be related to the tribe phylogeny and influenced by their diets. In the presented study, we expanded the set of venomics studies of the Philodryadini tribe, which paves new roads for further studies on the evolution and ecology of Dipsadidae snakes. Full article
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18 pages, 1071 KiB  
Article
Eating Behaviors, Lifestyle, and Ischemic Stroke: A Lebanese Case-Control Study
by Elise Maalouf, Souheil Hallit, Pascale Salameh and Hassan Hosseini
Int. J. Environ. Res. Public Health 2023, 20(2), 1487; https://doi.org/10.3390/ijerph20021487 - 13 Jan 2023
Cited by 20 | Viewed by 4761
Abstract
Background: Stroke is the second leading cause of death and the third leading cause of disability on a global scale. Most clinicians tend to underestimate the importance of diet and inadequate or dysfunctional eating attitudes in patients with a complicated relationship with food. [...] Read more.
Background: Stroke is the second leading cause of death and the third leading cause of disability on a global scale. Most clinicians tend to underestimate the importance of diet and inadequate or dysfunctional eating attitudes in patients with a complicated relationship with food. Concerned about the potential of an independent Lebanese approach, and also because prior international research has revealed a link between eating intake or choice and ischemic stroke risk, it was considered vital to broaden the scope of the literature and evaluate further the association of disordered eating attitudes and focus on the distinct relationship with food in the case of orthorexia nervosa (ON) in the Lebanese community. Consequently, the purpose of the present study is to investigate the potential association between pre-existing disordered eating attitudes, specifically ON, and ischemic stroke risk, with an emphasis on the evidence supporting a Mediterranean-style diet. Methods: This research is a case-control survey study involving 113 Lebanese individuals with ischemic stroke and 451 age-(within 5 years) and sex-matched controls recruited from several hospitals in Lebanon (April 2020–April 2021). Results: According to the findings of our first regression model, living 100 m from a crowded road (adjusted odds ratio [aOR]: 3.421, 95% confidence interval [CI]: 1.585–7.387), living 100 m from an electricity generator (aOR: 3.686, 95% CI: 1.681–8.085), higher waterpipe dependence (aOR: 1.204, 95% CI: 1.117–1.297), higher exposure to passive smoking (aOR: 2.651, 95% CI: 2.051–3.426), being married (aOR: 3.545, 95% CI: 1.297–9.689), having a low educational attainment (aOR: 0.239, 95% CI: 0.084–0.679), vigorous physical activity (aOR: 1.003, 95% CI: 1.001–1.006), and having more inappropriate eating (aOR: 1.040, 95% CI: 1.006–1.074) were all associated with higher odds of having ischemic stroke. Furthermore, atrial fibrillation (aOR: 2.945, 95% CI: 1.010–8.585), diabetes (aOR: 2.550, 95% CI: 1.169–5.561), heart diseases (aOR: 6.193, 95% CI: 2.196–17.463), and hypertension (aOR: 2.744, 95% CI: 1.049–7.180) were also linked to an increased risk of stroke. Moreover, having more orthorexia nervosa tendencies (aOR: 1.123, 95% CI: 1.021–1.235) was related to a higher odds of having an ischemic stroke, whereas better adherence to the MeD was significantly linked (aOR: 0.691, 95% CI: 0.583–0.819) to lower odds of ischemic stroke. Conclusions: Ischemic stroke patients were more likely to have disordered eating attitudes and orthorexic behaviors. Furthermore, the MeD has been found to be beneficial in reducing ischemic stroke risk. Despite the study’s focus, outdoor pollution, waterpipe dependence, and passive smoking were linked to ischemic stroke. In summary, this review suggests that improving one’s nutritional status and making a few lifestyle changes are key stroke prevention and treatment methods. Full article
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12 pages, 1745 KiB  
Article
Evaluation of the Use of a Road Diet Design: An Urban Corridor Case Study in Washington, DC
by Mohammad A. Aljamal, Derek Voight, Jacob Green, Jianwei Wang and Huthaifa I. Ashqar
Sustainability 2021, 13(16), 8964; https://doi.org/10.3390/su13168964 - 11 Aug 2021
Cited by 6 | Viewed by 4533
Abstract
A traditional road diet design converts a four-lane two-way road to a three-lane road consisting of two through lanes and a center two-way left turn lane. This paper introduces a new application of the road diet design in an urban corridor. Specifically, the [...] Read more.
A traditional road diet design converts a four-lane two-way road to a three-lane road consisting of two through lanes and a center two-way left turn lane. This paper introduces a new application of the road diet design in an urban corridor. Specifically, the new application converts a four-lane two-way road into a two-lane two-way road with full-time parking lanes in both directions. The paper analyzed the traffic impacts of the road diet application on the corridor of New Jersey Avenue, northwest, in the city of Washington, District of Columbia. The corridor included five signalized and one unsignalized intersections. Before-and-after analyses using Synchro 11 simulation and Site-Specific Empirical Bayes analysis were used to evaluate and compare existing and proposed scenarios. The proposed scenario provided various benefits including offering accessibility to the businesses in the area and acting as a traffic calming strategy. For signalized intersections, the overall performance remained the same for most intersections except for one intersection (on P Street), as it is significantly impacted by the road diet design due to the dramatic increase of traffic volumes in its minor streets as a result of diverting traffic volumes from the unsignalized intersection for left and through movements. Results showed that the use of a road diet design enhanced the unsignalized intersection performance due to the traffic volume divergence from its minor streets and enhanced the safety of the study area by decreasing the annual number of predicted crashes. To achieve better operational benefits and reflect traffic demands, the paper recommends to re-optimize signal timings when a road diet design is adopted. Full article
(This article belongs to the Special Issue Road Traffic Engineering and Sustainable Transportation)
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18 pages, 1352 KiB  
Review
Understanding the Long-Lasting Effects of Fetal Nutrient Restriction versus Exposure to an Obesogenic Diet on Islet-Cell Mass and Function
by Stephanie E. O’Hara, Kelly M. Gembus and Lisa M. Nicholas
Metabolites 2021, 11(8), 514; https://doi.org/10.3390/metabo11080514 - 4 Aug 2021
Cited by 7 | Viewed by 3236
Abstract
Early life represents a window of phenotypic plasticity. Thus, exposure of the developing fetus to a compromised nutritional environment can have long term consequences for their health. Indeed, undernutrition or maternal intake of an obesogenic diet during pregnancy leads to a heightened risk [...] Read more.
Early life represents a window of phenotypic plasticity. Thus, exposure of the developing fetus to a compromised nutritional environment can have long term consequences for their health. Indeed, undernutrition or maternal intake of an obesogenic diet during pregnancy leads to a heightened risk of type 2 diabetes (T2D) and obesity in her offspring in adult life. Given that abnormalities in beta-cell function are crucial in delineating the risk of T2D, studies have investigated the impact of these exposures on islet morphology and beta-cell function in the offspring in a bid to understand why they are more at risk of T2D. Interestingly, despite the contrasting maternal metabolic phenotype and, therefore, intrauterine environment associated with undernutrition versus high-fat feeding, there are a number of similarities in the genes/biological pathways that are disrupted in offspring islets leading to changes in function. Looking to the future, it will be important to define the exact mechanisms involved in mediating changes in the gene expression landscape in islet cells to determine whether the road to T2D development is the same or different in those exposed to different ends of the nutritional spectrum. Full article
(This article belongs to the Special Issue Islet Biology and Metabolism)
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22 pages, 2409 KiB  
Article
Perceived Importance of Public Health Risks in Greece: A Nationwide Survey of the Adult Population
by Anna Tzortzi, Melpo Kapetanstrataki, Georgios Rachiotis, Vaso Evangelopoulou, Eleni Leventou and Panagiotis Behrakis
Int. J. Environ. Res. Public Health 2021, 18(16), 8256; https://doi.org/10.3390/ijerph18168256 - 4 Aug 2021
Cited by 3 | Viewed by 2840
Abstract
The current study is the first to examine the perceptions of the Greek public towards selected health risks and prioritize perceived risk importance and the needs to be addressed for public health promotion. Participants were asked to consider the individual importance of selected [...] Read more.
The current study is the first to examine the perceptions of the Greek public towards selected health risks and prioritize perceived risk importance and the needs to be addressed for public health promotion. Participants were asked to consider the individual importance of selected risks and the top three most important risks. Data collection took place on February 2020 in a representative sample of the adult Greek population. Differences between groups were assessed with Chi-square tests. Logistic regression models were used to identify perceptions based on participants’ characteristics. Analysis was conducted in Stata 14, and 1976 adults participated in the survey: 48% male and 52% female. Road accidents, cancer and air pollution and environmental protection were considered the top three most important public health risks. Differences were observed between sexes; females were more concerned regarding the importance of the examined public health risks, and between age groups, younger ages considered STDs and contraception more important than older ages. Finally, non-smokers considered exercise and smoking to be more important than smokers. This is the first study to present and grade the public’s perceptions on the importance of public health risks in Greece. Our study’s prioritization of health risks could aid health authorities in improving and promoting the overall public health in Greece. Full article
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14 pages, 4288 KiB  
Article
Microscopic Traffic Simulation as a Decision Support System for Road Diet and Tactical Urbanism Strategies
by Bernice Liu, Amirarsalan Mehrara Molan, Anurag Pande, Jonathan Howard, Serena Alexander and Zhiliang Luo
Sustainability 2021, 13(14), 8076; https://doi.org/10.3390/su13148076 - 20 Jul 2021
Cited by 11 | Viewed by 5037
Abstract
Urban street networks in the United States have been primarily designed for automobile traffic with negligible considerations to non-motorized transportation users. Due to environmental issues and quality of life concerns, communities are reclaiming street spaces for active modes and slowing the speeds in [...] Read more.
Urban street networks in the United States have been primarily designed for automobile traffic with negligible considerations to non-motorized transportation users. Due to environmental issues and quality of life concerns, communities are reclaiming street spaces for active modes and slowing the speeds in their downtown. Moreover, tactical urbanism, i.e., the use of street space for innovative purposes other than moving automobile traffic, is becoming attractive due to reduced automobile travel demand and the need for outdoor activities in the age of the COVID-19 pandemic. This study provides details of the modeling of an urban downtown network (in the City of San Jose) using microscopic traffic simulation. The model is then applied to evaluate the effectiveness of street design changes at varying demand scenarios. The microsimulation approach was chosen because it allows for the detailed modeling and visualization of the transportation networks, including movements of individual vehicles, bicyclists, and pedestrians. The street design change demonstrated here involves one-way to two-way street conversion, but the framework of network-wide impact evaluation may also be used for complete street conversions. The base conditions network was also tested under different travel demand reduction scenarios (10%, 20%, and 30%) to identify the corridors in the city network in which the tactical urbanism strategies (e.g., open-air dining) may be best accommodated. The study provides framework for the use of a microscopic model as part of a decision support system to evaluate and effectively implement complete streets/tactical urbanism strategies. Full article
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