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13 pages, 1088 KiB  
Article
Mid-Term Recovery of Right Ventricular Function and Improvement of Left Ventricular Function After Da Silva Cone Procedure for Ebstein Anomaly
by Krithika Sundaram, Veenah Stoll, Luciana Da Fonseca Da Silva, Adam Christopher, Arvind Hoskoppal, Jacqueline Kreutzer, David Liddle, Laura Olivieri, Jacqueline Weinberg, Craig P. Dobson, José P. Da Silva and Tarek Alsaied
J. Cardiovasc. Dev. Dis. 2025, 12(7), 276; https://doi.org/10.3390/jcdd12070276 - 17 Jul 2025
Viewed by 388
Abstract
Background: The Da Silva Cone procedure for Ebstein anomaly has dramatically improved tricuspid valve competence and clinical outcomes. However, preoperative left ventricular (LV) dysfunction and immediate postoperative right ventricular (RV) systolic dysfunction are frequently observed. While excellent valve outcomes are well established, recovery [...] Read more.
Background: The Da Silva Cone procedure for Ebstein anomaly has dramatically improved tricuspid valve competence and clinical outcomes. However, preoperative left ventricular (LV) dysfunction and immediate postoperative right ventricular (RV) systolic dysfunction are frequently observed. While excellent valve outcomes are well established, recovery of biventricular function following the Cone remains less defined. This study aimed to evaluate longitudinal changes in RV and LV function postoperatively and over a minimum of six months post-Cone operation. Methods: A single center retrospective review of 134 patients who underwent Cone repair for Ebstein’s anomaly from 2016 to 2024 was performed. Echocardiograms were analyzed at three time points: preoperative (Time 1), hospital discharge (Time 2), and ≥6 months postoperative (Time 3). RV parameters included fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), and tricuspid S′. LV parameters included left ventricular ejection fraction (LVEF), end-diastolic volume indexed to body surface area (LVEDVi), left ventricular stroke volume (LVSVi), and mitral E/E′. Subgroup analyses examined outcomes by prior Glenn, Starnes procedure, and degree of RV dilation. Paired two sample t-tests were used to compare serial measures. Results: Median age at surgery was 7.8 years (IQR: 2.3–17.7). All patients had discharge echocardiograms; 70 had follow-up studies at ≥6 months. RV function declined postoperatively with reductions in FAC (35% to 21%), TAPSE (2.0 to 0.8 cm), and S′ (13 to 5 cm/s), all p < 0.001. By Time 3, these measures improved (FAC to 29%, TAPSE to 1.3 cm, S′ to 7 cm/s) but did not fully return to baseline. LVEDVi and LVSVi increased significantly by Time 3 (LVEDVi: 47 to 54 mL/m2; LVSVi: 30 to 34 mL/m2; p < 0.001), while LVEF remained unchanged. Patients with prior Glenn or Starnes had greater Time 1 LV volumes and lower RV function, but by Time 3, most differences resolved. Moderate–severe preoperative RV dilation was associated with worse RV function at Time 2 and normalized by Time 3. Conclusions: The Da Silva Cone procedure leads to early postoperative RV dysfunction with partial recovery over the mid-term follow-up. Concurrently, LV filling and stroke volume improve, reflecting favorable interventricular interaction. These findings support echocardiographic surveillance to guide functional recovery post-Cone and inform patient counseling. Full article
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15 pages, 2242 KiB  
Review
Early Echocardiographic Markers in Heart Failure with Preserved Ejection Fraction
by Annamaria Tavernese, Vincenzo Rizza, Valeria Cammalleri, Rocco Mollace, Cristina Carresi, Giorgio Antonelli, Nino Cocco, Luca D’Antonio, Martina Gelfusa, Francesco Piccirillo, Annunziata Nusca and Gian Paolo Ussia
J. Cardiovasc. Dev. Dis. 2025, 12(6), 229; https://doi.org/10.3390/jcdd12060229 - 16 Jun 2025
Viewed by 679
Abstract
Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases and remains diagnostically challenging due to its heterogeneous pathophysiology and often subtle myocardial dysfunction. Conventional echocardiographic parameters, such as left ventricular ejection fraction (LVEF) and the left atrial [...] Read more.
Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases and remains diagnostically challenging due to its heterogeneous pathophysiology and often subtle myocardial dysfunction. Conventional echocardiographic parameters, such as left ventricular ejection fraction (LVEF) and the left atrial volume index (LAVI), frequently fail to detect early functional changes. Advanced echocardiographic techniques have emerged as valuable tools for early diagnosis and risk stratification. Global Longitudinal Strain (GLS) allows for the identification of subclinical systolic dysfunction, even with preserved LVEF. Left Atrial Strain (LAS), particularly reservoir and pump strain, provides sensitive markers of diastolic function and elevated filling pressures, offering additional diagnostic and prognostic insights. Myocardial Work (MW), through non-invasive pressure–strain loops, enables load-independent assessment of contractility, while Right Ventricular Free Wall Longitudinal Strain (RVFWLS) captures early right heart involvement, often present in advanced HFpEF. The integration of these advanced parameters can enhance diagnostic precision and guide personalized treatment strategies. This review highlights the current evidence and clinical applications of strain-based imaging in HFpEF, underscoring the importance of a multiparametric, pathophysiology-oriented approach in heart failure evaluation. Full article
(This article belongs to the Special Issue Role of Cardiovascular Imaging in Heart Failure)
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43 pages, 6641 KiB  
Systematic Review
A Meta-Analysis of Clinical and Echocardiographic Outcomes of Physiological Versus Conventional Pacing
by Patrycja Paluszkiewicz, Adrian Martuszewski, Jacek Smereka and Jacek Gajek
Biomedicines 2025, 13(6), 1359; https://doi.org/10.3390/biomedicines13061359 - 31 May 2025
Viewed by 585
Abstract
Background: Conduction system pacing (CSP), encompassing His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), has emerged as an alternative to conventional pacing methods such as right ventricular pacing (RVP) and biventricular pacing (BVP). This meta-analysis aimed to compare the [...] Read more.
Background: Conduction system pacing (CSP), encompassing His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), has emerged as an alternative to conventional pacing methods such as right ventricular pacing (RVP) and biventricular pacing (BVP). This meta-analysis aimed to compare the effects of CSP versus conventional pacing on left ventricular function and selected clinical and electrophysiological outcomes. Methods: Prospective and retrospective studies (randomized, observational, registry-based) reporting pre-post data or direct comparisons between CSP (HBP, LBBAP) and conventional methods (BVP, RVP) for at least one of LVEF, LVESV, LVEDV, QRS duration, NYHA class, NT-proBNP, R-wave, or pacing threshold were included. PubMed and Web of Science databases were searched up to 31 March 2025. Quality assessment (QualSyst), publication bias (Egger’s test, trim-and-fill), subgroup analyses, and meta-regression (follow-up duration) were performed. The review was registered in the INPLASY database (INPLASY202540050). Results: 28 studies (8777 patients, 47 comparisons) were included. CSP significantly improved LVEF (SMD = 1.16; 95%CI: 0.94–1.38), shortened QRS duration (SMD = 0.75; 95%CI: 0.24–1.26), and reduced NYHA class (SMD = 1.94; 95%CI: 1.59–2.29), NT-proBNP levels (SMD = 1.27; 95%CI:0.85–1.69), LVEDV (SMD = 0.90; 95%CI: 0.42–1.38), and LVESV (SMD = 1.31; 95%CI: 0.81–1.81). In head-to-head comparisons, LBBAP and HBP showed similar efficacy, both superior to conventional pacing. Improvement in LVEF significantly correlated with longer follow-up (p = 0.004). Publication bias was non-significant (Egger p = 0.15), despite high heterogeneity (I2 > 90%). Conclusions: CSP demonstrated superior clinical and echocardiographic outcomes compared to conventional pacing. Limitations include the predominance of non-randomized studies, high heterogeneity, and variability in follow-up duration, supporting the need for high-quality randomized trials. Full article
(This article belongs to the Special Issue Cardiomyopathies and Heart Failure: Charting the Future)
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9 pages, 362 KiB  
Article
Syncope in Pulmonary Thromboembolism: A Cross-Sectional Analysis of Risk Factors and the Prognostic Value of Syncope
by Songul Ozyurt, Neslihan Ozcelik, Elvan Senturk Topaloglu, Abdurrahman Kotan, Aziz Gumus and Unal Sahin
J. Clin. Med. 2025, 14(7), 2501; https://doi.org/10.3390/jcm14072501 - 6 Apr 2025
Viewed by 732
Abstract
Background/Objectives: This study investigated the frequency of syncope, factors associated with syncope, and the relationship between syncope and mortality in patients with pulmonary thromboembolism (PTE). Methods: This study was planned as single-center retrospective and cross-sectional research. The PTE diagnosis was confirmed [...] Read more.
Background/Objectives: This study investigated the frequency of syncope, factors associated with syncope, and the relationship between syncope and mortality in patients with pulmonary thromboembolism (PTE). Methods: This study was planned as single-center retrospective and cross-sectional research. The PTE diagnosis was confirmed by partial or complete filling defects in at least one branch of the pulmonary circulation seen on pulmonary spiral computed tomography angiography. Patients’ demographic data, symptoms, location of pulmonary embolism, Simplified Pulmonary Embolism Severity Index (sPESI) risk group, European Society of Cardiology (ESC) risk group, in-hospital mortality rate, and 30-day mortality rate were recorded. The presence of syncope and associated factors as well as the relationship between syncope and mortality were investigated. Results: This study included 589 consecutive patients diagnosed with PTE. The mean age was 70 ± 15 years, and 58.7% of the patients were women. Syncope was detected in 12.4% of the patients. Female sex, pulse rate, thrombosis in the main pulmonary artery, and right ventricular dysfunction on an echocardiogram were more prevalent in the syncope group. In-hospital mortality was 2.1 times higher in the syncope group. Elevated troponin levels increased the occurrence of syncope by 4.9-fold, whereas the presence of thrombosis in the main pulmonary artery and signs of right ventricular failure increased syncope occurrence by 4.3- and 3.1-fold, respectively. Conclusions: In the presence of syncope, patients with pulmonary thromboembolism, embolism in the main pulmonary arteries, high troponin values, right heart failure, and a high sPESI risk group should be carefully assessed and closely monitored for mortality, and reperfusion therapy should be considered as necessary. Full article
(This article belongs to the Section Respiratory Medicine)
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38 pages, 2181 KiB  
Review
Is Inducible Nitric Oxide Synthase (iNOS) Promising as a New Target Against Pulmonary Hypertension?
by Piotr Ryszkiewicz, Eberhard Schlicker and Barbara Malinowska
Antioxidants 2025, 14(4), 377; https://doi.org/10.3390/antiox14040377 - 21 Mar 2025
Cited by 1 | Viewed by 1516
Abstract
Pulmonary hypertension (PH) is a progressive disease characterized by elevated blood pressure in the pulmonary arteries, associated also with inflammation and oxidative stress. Inducible nitric oxide synthase (iNOS) is one of the key mediators of inflammation and immune system activation. Although preclinical studies [...] Read more.
Pulmonary hypertension (PH) is a progressive disease characterized by elevated blood pressure in the pulmonary arteries, associated also with inflammation and oxidative stress. Inducible nitric oxide synthase (iNOS) is one of the key mediators of inflammation and immune system activation. Although preclinical studies mostly suggest a detrimental role of iNOS overactivation in PH, there is a lack of exhaustive analyses and summaries. Therefore, this literature overview aims to fill this gap. The involvement of iNOS in the pathogenesis of the four main clinical groups of PH is discussed to assess whether targeting iNOS could be a promising way to treat PH. iNOS expression patterns in the organs primarily affected by PH are analyzed both in animals and in humans. Consequently, the effectiveness of pharmacological iNOS inhibition and/or iNOS gene deletion is discussed and compared, also with reference to the activity of constitutive NOS isoforms, particularly endothelial NOS (eNOS). Overall, our overview suggests that selective iNOS inhibitors could be considered as a novel treatment strategy for PH, as decreases in right ventricular and pulmonary artery pressure, the alleviation of ventricular hypertrophy, and improvements of pulmonary and cardiac function were observed, among others. Nevertheless, further research efforts in this area are needed. Full article
(This article belongs to the Special Issue Nitric Oxide and Redox Mechanisms)
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10 pages, 686 KiB  
Article
Utility of Simultaneous Left Atrial Strain–Volume Relationship During Passive Leg Lift to Identify Elevated Left Ventricular Filling Pressure—A Proof-of-Concept Study
by Ashwin Venkateshvaran, Urban Wiklund, Per Lindqvist and Thomas Lindow
J. Clin. Med. 2024, 13(24), 7629; https://doi.org/10.3390/jcm13247629 - 14 Dec 2024
Viewed by 1100
Abstract
Background: The assessment of left ventricular (LV) filling pressure in heart failure (HF) poses a diagnostic challenge, as HF patients may have normal LV filling pressures at rest but often display elevated LV filling pressures during exercise. Rapid preload increase during passive [...] Read more.
Background: The assessment of left ventricular (LV) filling pressure in heart failure (HF) poses a diagnostic challenge, as HF patients may have normal LV filling pressures at rest but often display elevated LV filling pressures during exercise. Rapid preload increase during passive leg lift (PLL) may unmask HF in such challenging scenarios. We explored the dynamic interplay between simultaneous left atrial (LA) function and volume using LA strain/volume loops during rest and PLL and compared its diagnostic performance with conventional echocardiographic surrogates to detect elevated LV filling pressure. Methods: We retrospectively reviewed 35 patients with clinical HF who underwent simultaneous echocardiography and right heart catheterization before and immediately after PLL. Patients with atrial fibrillation (n = 4) were excluded. Twenty age-matched, healthy controls were added as controls. LA reservoir strain (LASr) was analyzed using speckle-tracking echocardiography. LA strain–volume loops were generated, including the best-fit linear regression line employing simultaneous LASr and LA volume. Results: LA strain–volume slope was lower for HF patients when compared with controls (0.71 vs. 1.22%/mL, p < 0.001). During PLL, the LA strain–volume slope displayed a moderately strong negative correlation with invasive pulmonary arterial wedge pressure (PAWP) (r = −0.71, p < 0.001). At a 0.74%/mL cut-off, the LA strain–volume slope displayed 88% sensitivity and 86% specificity to identify elevated PAWP (AUC 0.89 [0.76–1.00]). In comparison, LASr demonstrated strong but numerically lower diagnostic performance (AUC 0.82 [0.67–0.98]), and mitral E/e’ showed poor performance (AUC 0.57 [0.32–0.82]). Conclusions: In this proof-of-concept study, LA strain–volume characteristics provide incremental diagnostic value over conventional echocardiographic measures in the identification of elevated LV filling pressure. Full article
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9 pages, 1724 KiB  
Article
Time Interval Between Right Ventricular Early Diastolic Velocity by Tissue and Pulse Wave Doppler: An Index of Right Atrial Pressure in Pulmonary Hypertension Patients
by Costanza Natalia Julia Colombo, Francesco Corradi, Valentino Dammassa, Davide Colombo, Alessandro Fasolino, Mauro Acquaro, Susanna Price, Stefano Ghio and Guido Tavazzi
J. Clin. Med. 2024, 13(21), 6349; https://doi.org/10.3390/jcm13216349 - 23 Oct 2024
Cited by 1 | Viewed by 1096
Abstract
Background: A reversal of time difference between the onset of early diastolic velocity (e’) during tissue Doppler imaging and the onset of mitral inflow (E) has been observed in cases of elevated left atrial pressure. Whether this interval (Te’-E) may be [...] Read more.
Background: A reversal of time difference between the onset of early diastolic velocity (e’) during tissue Doppler imaging and the onset of mitral inflow (E) has been observed in cases of elevated left atrial pressure. Whether this interval (Te’-E) may be useful to assess right atrial pressure has never been investigated, neither in healthy subjects nor in pulmonary hypertension patients. Methods: Right ventricular Te’-E was assessed in patients with pre-capillary pulmonary hypertension and compared with healthy volunteers who underwent comprehensive echocardiography examination. Te’-E is the difference between the interval from R wave at the superimposed electrocardiogram to the e’ wave during right ventricular tissue Doppler imaging and the interval from the R wave to transtricuspid E wave during pulsed wave Doppler imaging. Right atrial pressure was invasively measured in pulmonary hypertension patients. Results: Fifty-six patients were enrolled. Te’-E was prolonged in pulmonary hypertension subjects compared with healthy subjects (p < 0.001). Amongst the pulmonary hypertension patients, strong correlations were found between Te’-E and right atrial pressure (r = −0.885, p < 0.001), systolic pulmonary pressure (r = −0.85, p < 0.001) and the duration of tricuspid regurgitation (r = 0.72, p < 0.001). The area under the receiver operating characteristic curve of Te’-E in identifying right atrial pressure higher than 15 mm of mercury was 0.992 (sensitivity 100%, specificity 83%). Conclusions: In contrast to the left ventricle, there is a delay in the proto-diastolic filling in pulmonary hypertension patients, which correlates with the increase in systolic pulmonary arterial pressure, right atrial pressure, tricuspid regurgitation duration and restrictive diastolic pattern. Full article
(This article belongs to the Section Intensive Care)
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12 pages, 915 KiB  
Article
Exercise Intolerance Is Associated with Cardiovascular Dysfunction in Long COVID-19 Syndrome
by Angelos Vontetsianos, Nikolaos Chynkiamis, Maria Ioanna Gounaridi, Christina Anagnostopoulou, Christiana Lekka, Stavroula Zaneli, Nektarios Anagnostopoulos, Evangelos Oikonomou, Manolis Vavuranakis, Nikoletta Rovina, Andriana I. Papaioannou, Georgios Kaltsakas, Nikolaos Koulouris and Ioannis Vogiatzis
J. Clin. Med. 2024, 13(14), 4144; https://doi.org/10.3390/jcm13144144 - 16 Jul 2024
Cited by 1 | Viewed by 2637
Abstract
Background/Objectives: Cardiorespiratory complications are commonly reported among patients with long COVID-19 syndrome. However, their effects on exercise capacity remain inconclusive. We investigated the impact of long COVID-19 on exercise tolerance combining cardiopulmonary exercise testing (CPET) with resting echocardiographic data. Methods: Forty-two patients (55 [...] Read more.
Background/Objectives: Cardiorespiratory complications are commonly reported among patients with long COVID-19 syndrome. However, their effects on exercise capacity remain inconclusive. We investigated the impact of long COVID-19 on exercise tolerance combining cardiopulmonary exercise testing (CPET) with resting echocardiographic data. Methods: Forty-two patients (55 ± 13 years), 149 ± 92 days post-hospital discharge, and ten healthy age-matched participants underwent resting echocardiography and an incremental CPET to the limit of tolerance. Left ventricular global longitudinal strain (LV-GLS) and the left ventricular ejection fraction (LVEF) were calculated to assess left ventricular systolic function. The E/e’ ratio was estimated as a surrogate of left ventricular end-diastolic filling pressures. Tricuspid annular systolic velocity (SRV) was used to assess right ventricular systolic performance. Through tricuspid regurgitation velocity and inferior vena cava diameter, end-respiratory variations in systolic pulmonary artery pressure (PASP) were estimated. Peak work rate (WRpeak) and peak oxygen uptake (VO2peak) were measured via a ramp incremental symptom-limited CPET. Results: Compared to healthy participants, patients had a significantly (p < 0.05) lower LVEF (59 ± 4% versus 49 ± 5%) and greater left ventricular end-diastolic diameter (48 ± 2 versus 54 ± 5 cm). In patients, there was a significant association of E/e’ with WRpeak (r = −0.325) and VO2peak (r = −0.341). SRV was significantly associated with WRpeak (r = 0.432) and VO2peak (r = 0.556). LV-GLS and PASP were significantly correlated with VO2peak (r = −0.358 and r = −0.345, respectively). Conclusions: In patients with long COVID-19 syndrome, exercise intolerance is associated with left ventricular diastolic performance, left ventricular end-diastolic pressure, PASP and SRV. These findings highlight the interrelationship of exercise intolerance with left and right ventricular performance in long COVID-19 syndrome. Full article
(This article belongs to the Section Cardiovascular Medicine)
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12 pages, 2502 KiB  
Review
The Role of Speckle Tracking Echocardiography in the Evaluation of Advanced-Heart-Failure Patients
by Luca Martini, Matteo Lisi, Maria Concetta Pastore, Francesca Maria Righini, Andrea Rubboli, Michael Y. Henein and Matteo Cameli
J. Clin. Med. 2024, 13(14), 4037; https://doi.org/10.3390/jcm13144037 - 10 Jul 2024
Cited by 5 | Viewed by 3230
Abstract
Health care is currently showing a fall in heart failure (HF) incidence and prevalence, particularly in developed countries, but with only a subset receiving appropriate therapy to protect the heart against maladaptive processes such as fibrosis and hypertrophy. Appropriate markers of advanced HF [...] Read more.
Health care is currently showing a fall in heart failure (HF) incidence and prevalence, particularly in developed countries, but with only a subset receiving appropriate therapy to protect the heart against maladaptive processes such as fibrosis and hypertrophy. Appropriate markers of advanced HF remain unidentified, which would help in choosing the most suitable therapy and avoid major compliance problems. Speckle tracking echocardiography (STE) is a good choice, being a non-invasive imaging technique which is able to assess cardiac deformation in a variety of conditions. Several multicenter studies and meta-analyses have demonstrated the clinical application and accuracy of STE in early and late stages of HF, as well as its association with both left ventricular (LV) filling pressures and myocardial oxygen consumption. Furthermore, STE assists in assessing right ventricular free-wall longitudinal strain (RVFWLS), which is a solid predictor of right ventricle failure (RVF) following LV assist device (LVAD) implantation. However, STE is known for its limitations; despite these, it has been shown to explain symptoms and signs and also to be an accurate prognosticator. The aim of this review is to examine the advantages of STE in the early evaluation of myocardial dysfunction and its correlation with right heart catheterization (RHC) parameters, which should have significant clinical relevance in the management of HF patients. Full article
(This article belongs to the Section Cardiovascular Medicine)
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14 pages, 2909 KiB  
Article
CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF
by Annika Weidenhammer, Suriya Prausmüller, Clemens Partsch, Georg Spinka, Bianca Luckerbauer, Mirella Larch, Henrike Arfsten, Ramy Abdel Mawgoud, Philipp E. Bartko, Georg Goliasch, Stefan Kastl, Christian Hengstenberg, Martin Hülsmann and Noemi Pavo
Cells 2023, 12(24), 2832; https://doi.org/10.3390/cells12242832 - 13 Dec 2023
Cited by 3 | Viewed by 1718
Abstract
Background: CILP-1 regulates myocardial fibrotic response and remodeling and was reported to indicate right ventricular dysfunction (RVD) in pulmonary hypertension (PH) and heart failure (HF). This study examines CILP-1 as a potential biomarker for RVD and prognosis in heart failure with reduced ejection [...] Read more.
Background: CILP-1 regulates myocardial fibrotic response and remodeling and was reported to indicate right ventricular dysfunction (RVD) in pulmonary hypertension (PH) and heart failure (HF). This study examines CILP-1 as a potential biomarker for RVD and prognosis in heart failure with reduced ejection fraction (HFrEF) patients on guideline-directed medical therapy. Methods: CILP-1 levels were measured in 610 HFrEF patients from a prospective registry with biobanking (2016–2022). Correlations with echocardiographic and hemodynamic data and its association with RVD and prognosis were analyzed. Results: The median age was 62 years (Q1–Q3: 52–72), 77.7% of patients were male, and the median NT-proBNP was 1810 pg/mL (Q1–Q3: 712–3962). CILP-1 levels increased with HF severity, as indicated by NT-proBNP and NYHA class (p < 0.0001, for both). CILP-1 showed a weak–moderate direct association with increased left ventricular filling pressures and its sequalae, i.e., backward failure (LA diameter rs = 0.15, p = 0.001; sPAP rs = 0.28, p = 0.010; RVF rs = 0.218, p < 0.0001), but not with cardiac index (CI) and systemic vascular resistance (SVR). CILP-1 trended as a risk factor for all-cause mortality (crude HR for 500 pg/mL increase: 1.03 (95%CI: 1.00–1.06), p = 0.053) but lost significance when it was adjusted for NT-proBNP (adj. HR: 1.00 (95%CI: 1.00–1.00), p = 0.770). No association with cardiovascular hospitalization was observed. Conclusions: CILP-1 correlates with HFrEF severity and may indicate an elevated risk for all-cause mortality, though it is not independent from NT-proBNP. Increased CILP-1 is associated with backward failure and RVD rather than forward failure. Whether CILP-1 release in this context is based on elevated pulmonary pressures or is specific to RVD needs to be further investigated. Full article
(This article belongs to the Special Issue Understanding Biomarkers in Cardiology Volume II)
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12 pages, 7358 KiB  
Article
The Left Atrial Area Derived Cardiovascular Magnetic Resonance Left Ventricular Filling Pressure Equation Shows Superiority over Integrated Echocardiography
by Ciaran Grafton-Clarke, Gareth Matthews, Rebecca Gosling, Peter Swoboda, Alexander Rothman, Jim M. Wild, David G. Kiely, Robin Condliffe, Samer Alabed, Andrew J. Swift and Pankaj Garg
Medicina 2023, 59(11), 1952; https://doi.org/10.3390/medicina59111952 - 4 Nov 2023
Cited by 2 | Viewed by 1879
Abstract
Background and objectives: Evaluating left ventricular filling pressure (LVFP) plays a crucial role in diagnosing and managing heart failure (HF). While traditional assessment methods involve multi-parametric transthoracic echocardiography (TTE) or right heart catheterisation (RHC), cardiovascular magnetic resonance (CMR) has emerged as a [...] Read more.
Background and objectives: Evaluating left ventricular filling pressure (LVFP) plays a crucial role in diagnosing and managing heart failure (HF). While traditional assessment methods involve multi-parametric transthoracic echocardiography (TTE) or right heart catheterisation (RHC), cardiovascular magnetic resonance (CMR) has emerged as a valuable diagnostic tool in HF. This study aimed to assess a simple CMR-derived model to estimate pulmonary capillary wedge pressure (PCWP) in a cohort of patients with suspected or proven heart failure and to investigate its performance in risk-stratifying patients. Materials and methods: A total of 835 patients with breathlessness were evaluated using RHC and CMR and split into derivation (85%) and validation cohorts (15%). Uni-variate and multi-variate linear regression analyses were used to derive a model for PCWP estimation using CMR. The model’s performance was evaluated by comparing CMR-derived PCWP with PCWP obtained from RHC. Results: A CMR-derived PCWP incorporating left ventricular mass and the left atrial area (LAA) demonstrated good diagnostic accuracy. The model correctly reclassified 66% of participants whose TTE was ‘indeterminate’ or ‘incorrect’ in identifying raised filling pressures. On survival analysis, the CMR-derived PCWP model was predictive for mortality (HR 1.15, 95% CI 1.04–1.28, p = 0.005), which was not the case for PCWP obtained using RHC or TTE. Conclusions: The simplified CMR-derived PCWP model provides an accurate and practical tool for estimating PCWP in patients with suspected or proven heart failure. Its predictive value for mortality suggests the ability to play a valuable adjunctive role in echocardiography, especially in cases with unclear echocardiographic assessment. Full article
(This article belongs to the Special Issue Application of Cardiac Imaging in Heart Disease)
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11 pages, 2651 KiB  
Article
Is Marfan Syndrome Associated with Primary Structural Changes in the Left Atrium?
by Kun Zhang, Lucas Ernst, Isabel Schobert, Karla Philipp, Georg Böning, Frank R. Heinzel, Leif-Hendrik Boldt and Petra Gehle
Diagnostics 2023, 13(20), 3278; https://doi.org/10.3390/diagnostics13203278 - 23 Oct 2023
Cited by 3 | Viewed by 1884
Abstract
Marfan syndrome (MFS) is an autosomal-dominant multisystem connective tissue disorder that is based on mutations in the FBN1 gene and variably affects different organs, including the heart. In this study, we investigated cardiac function with a focus on the left atrium (LA) in [...] Read more.
Marfan syndrome (MFS) is an autosomal-dominant multisystem connective tissue disorder that is based on mutations in the FBN1 gene and variably affects different organs, including the heart. In this study, we investigated cardiac function with a focus on the left atrium (LA) in a relatively large cohort of patients with MFS. After screening of 1165 patients that had been examined in our center between 2016 and 2020, 231 adult MFS patients with and without aortic operation were included in our study and compared to a healthy control group (n = 106). Cardiac function was assessed by transthoracic echocardiography and NT-proBNP was used as a secretory marker. Most (94.8%) of the patients received genetic testing. Left ventricular function was within normal ranges and not impaired. Interestingly, we found that LA size and secretory activity were increased in MFS patients, despite normal left ventricular filling pressures. This finding was even more pronounced in MFS patients with prior aortic surgery. A correlation between LA size or NT-proBNP levels and the type of pathogenic FBN1 variant could not be identified. Right ventricular function and right atrial size were increased only in MFS patients that had undergone aortic surgery. In conclusion, these findings suggest that MFS leads to structural changes in the LA that are not solely resulting from left ventricular dysfunction, but probably can be considered a primary pathology of MFS. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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12 pages, 1311 KiB  
Article
Computed Tomography Pulmonary Angiography Prediction of Adverse Long-Term Outcomes in Chronic Thromboembolic Pulmonary Hypertension: Correlation with Hemodynamic Measurements Pre- and Post-Pulmonary Endarterectomy
by Deepa Gopalan, Jan Y. J. Riley, Kai’en Leong, Senan Alsanjari, William Auger and Peter Lindholm
Tomography 2023, 9(5), 1787-1798; https://doi.org/10.3390/tomography9050142 - 26 Sep 2023
Cited by 1 | Viewed by 2687
Abstract
CT pulmonary angiography is commonly used in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). This work was conducted to determine if cardiac chamber size on CTPA may also be useful for predicting the outcome of CTEPH treatment. A retrospective analysis of paired CTPA and [...] Read more.
CT pulmonary angiography is commonly used in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). This work was conducted to determine if cardiac chamber size on CTPA may also be useful for predicting the outcome of CTEPH treatment. A retrospective analysis of paired CTPA and right heart hemodynamics in 33 consecutive CTEPH cases before and after pulmonary thromboendarterectomy (PTE) was performed. Semiautomated and manual CT biatrial and biventricular size quantifications were correlated with mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR) and cardiac output. The baseline indexed right atrioventricular volumes were twice the left atrioventricular volumes, with significant (p < 0.001) augmentation of left heart filling following PTE. Except for the left atrial volume to cardiac index, all other chamber ratios significantly correlated with hemodynamics. Left to right ventricular ratio cut point <0.82 has high sensitivity (91% and 97%) and specificity (88% and 85%) for identifying significant elevations of mPAP and PVR, respectively (AUC 0.90 and 0.95), outperforming atrial ratios (sensitivity 78% and 79%, specificity 82% and 92%, and AUC 0.86 and 0.91). Manual LV:RV basal dimension ratio correlates strongly with semiautomated volume ratio (r 0.77, 95% CI 0.64–0.85) and is an expeditious alternative with comparable prognostic utility (AUC 0.90 and 0.95). LV:RV dimension ratio of <1.03 and ≤0.99 (alternatively expressed as RV:LV ratio of >0.97 and ≥1.01) is a simple metric that can be used for CTEPH outcome prediction. Full article
(This article belongs to the Section Cardiovascular Imaging)
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31 pages, 28195 KiB  
Review
Balloon Dilatation in the Management of Congenital Obstructive Lesions of the Heart: Review of Author’s Experiences and Observations—Part II
by P. Syamasundar Rao
J. Cardiovasc. Dev. Dis. 2023, 10(7), 288; https://doi.org/10.3390/jcdd10070288 - 6 Jul 2023
Cited by 2 | Viewed by 1802
Abstract
While investigating the outcomes of balloon dilatation procedures in patients with congenital obstructive lesions of the heart, several parallel observations were made. The purpose of this review is to present these observations/phenomena/innovations related to balloon dilatation of pulmonary stenosis (PS), aortic stenosis (AS), [...] Read more.
While investigating the outcomes of balloon dilatation procedures in patients with congenital obstructive lesions of the heart, several parallel observations were made. The purpose of this review is to present these observations/phenomena/innovations related to balloon dilatation of pulmonary stenosis (PS), aortic stenosis (AS), and aortic coarctation (AC). In subjects who had balloon pulmonary valvuloplasty (BPV), development of infundibular obstruction, electrocardiographic (ECG) changes, changes in right ventricular filling, role of balloon/annulus ratios on the results of BPV, and double balloon vs. single balloon BPV will be reviewed. In patients who had balloon aortic valvuloplasty (BAV), causes of aortic insufficiency and trans-umbilical venous approach for BAV are tackled. In children who had balloon angioplasty (BA) of AC, aortic remodeling and biophysical response after BA of AC are discussed. Full article
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13 pages, 5637 KiB  
Review
Role of Exercise Stress Echocardiography in Pulmonary Hypertension
by Mojca Škafar, Jana Ambrožič, Janez Toplišek and Marta Cvijić
Life 2023, 13(6), 1385; https://doi.org/10.3390/life13061385 - 14 Jun 2023
Cited by 2 | Viewed by 2963
Abstract
Resting and exercise right heart catheterisation is the gold standard method to diagnose and differentiate types of pulmonary hypertension (PH). As it carries technical challenges, the question arises if non-invasive exercise stress echocardiography may be used as an alternative. Exercise echocardiography can unmask [...] Read more.
Resting and exercise right heart catheterisation is the gold standard method to diagnose and differentiate types of pulmonary hypertension (PH). As it carries technical challenges, the question arises if non-invasive exercise stress echocardiography may be used as an alternative. Exercise echocardiography can unmask exercise PH, detect the early stages of left ventricular diastolic dysfunction, and, therefore, differentiate between pre- and post-capillary PH. Regardless of the underlying aetiology, a developed PH is associated with increased mortality. Parameters of overt right ventricle (RV) dysfunction, including RV dilation, reduced RV ejection fraction, and elevated right-sided filling pressures, are detectable with resting echocardiography and are associated with worse outcome. However, these measures all fail to identify occult RV dysfunction. Echocardiographic measures of RV contractile reserve during exercise echocardiography are very promising and provide incremental prognostic information on clinical outcome. In this paper, we review pulmonary haemodynamic response to exercise, briefly describe the modalities for assessing pulmonary haemodynamics, and discuss in depth the contemporary key clinical application of exercise stress echocardiography in patients with PH. Full article
(This article belongs to the Special Issue New Insights into Cardiovascular and Exercise Physiology)
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