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Keywords = resonant grating

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22 pages, 5354 KB  
Article
Enhanced Sensitivity in D-Shaped Optical Fiber SPR Sensor via Ag-α-Fe2O3 Grating
by Shuai Yuan, Bingyang Yuan and Jiu Deng
Micromachines 2026, 17(2), 183; https://doi.org/10.3390/mi17020183 - 29 Jan 2026
Viewed by 78
Abstract
The development of high-performance optical fiber sensors based on surface plasmon resonance (SPR) represents a significant advancement in precision detection technology, particularly for biomedical and environmental monitoring applications requiring real-time response and minimal sample consumption. This research conducts a systematic numerical investigation of [...] Read more.
The development of high-performance optical fiber sensors based on surface plasmon resonance (SPR) represents a significant advancement in precision detection technology, particularly for biomedical and environmental monitoring applications requiring real-time response and minimal sample consumption. This research conducts a systematic numerical investigation of a D-shaped fiber SPR sensor incorporating an optimized silver-hematite (Ag-α-Fe2O3) composite grating structure. Through comprehensive finite element simulations and parameter analysis, we demonstrate that controlling the silver layer thickness at 45 nm while maintaining the α-Fe2O3 thickness at 12 nm achieves optimal electric field confinement. The grating gap width optimization at 30 nm enables maximum sensitivity through enhanced localized surface plasmon resonance effects, while the residual cladding thickness of 0.5 μm provides the ideal balance between detection accuracy and sensitivity. The research establishes fundamental design principles for high-performance SPR sensors by elucidating the critical relationships between geometric parameters and sensing characteristics, providing valuable insights for developing next-generation sensors with enhanced performance for advanced sensing applications in environmental monitoring and medical diagnostics. Full article
(This article belongs to the Special Issue Integrated Photonics and Optoelectronics, 3rd Edition)
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20 pages, 4673 KB  
Review
Spiral-Grating Tapered Gold Tip Used for Micro-Nanoscale Multi-Functional Sensing
by Rongtao Huang, Yuxin Chen and Zhi-Yuan Li
Sensors 2026, 26(2), 704; https://doi.org/10.3390/s26020704 - 21 Jan 2026
Viewed by 103
Abstract
Optical fiber surface plasmon resonance (SPR) sensing, as a label-free, highly sensitive, rapid-response and in situ detection technology, has demonstrated significant utility in various physical, chemical and biological detection applications. This paper focuses on a fiber-integrated microscale spiral-grating tapered gold tip SPR sensor. [...] Read more.
Optical fiber surface plasmon resonance (SPR) sensing, as a label-free, highly sensitive, rapid-response and in situ detection technology, has demonstrated significant utility in various physical, chemical and biological detection applications. This paper focuses on a fiber-integrated microscale spiral-grating tapered gold tip SPR sensor. We first introduce the working principle and sensing capability with high space–time resolution of this SPR microsensor. Then we provide a comprehensive description of its application in the study on the important fundamental scientific issue of liquid–liquid diffusion. Finally, we demonstrate the application of the spiral-grating tapered gold tip to plasmonic enhanced fluorescence and scanning near-field optical microscopy. By systematically summarizing the excellent multifunctional sensing performance of the microscale spiral-grating tapered gold tip, this paper aims to provide new optical schemes and tools for the study on complex physicochemical processes and light-matter interactions at microscale and nanoscale. Full article
(This article belongs to the Special Issue Nanophotonic Materials and Sensor Devices)
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26 pages, 4053 KB  
Article
Design and Characterization of Gold Nanorod Hyaluronic Acid Hydrogel Nanocomposites for NIR Photothermally Assisted Drug Delivery
by Alessandro Molinelli, Leonardo Bianchi, Elisa Lacroce, Zoe Giorgi, Laura Polito, Ada De Luigi, Francesca Lopriore, Francesco Briatico Vangosa, Paolo Bigini, Paola Saccomandi and Filippo Rossi
Gels 2026, 12(1), 88; https://doi.org/10.3390/gels12010088 - 19 Jan 2026
Viewed by 193
Abstract
The combination of gold nanoparticles (AuNPs) with hydrogels has drawn significant interest in the design of smart materials as advanced platforms for biomedical applications. These systems endow light-responsiveness enabled by the AuNPs localized surface plasmon resonance (LSPR) phenomenon. In this study, we propose [...] Read more.
The combination of gold nanoparticles (AuNPs) with hydrogels has drawn significant interest in the design of smart materials as advanced platforms for biomedical applications. These systems endow light-responsiveness enabled by the AuNPs localized surface plasmon resonance (LSPR) phenomenon. In this study, we propose a nanocomposite hydrogel in which gold nanorods (AuNRs) are included in an agarose–carbomer–hyaluronic acid (AC-HA)-based hydrogel matrix to study the correlation between light irradiation, local temperature increase, and drug release for potential light-assisted drug delivery applications. The gel is obtained through a facile microwave-assisted polycondensation reaction, and its properties are investigated as a function of both the hyaluronic acid molecular weight and ratio. Afterwards, AuNRs are incorporated in the AC-HA formulation, before the sol–gel transition, to impart light-responsiveness and optical properties to the otherwise inert polymeric matrix. Particular attention is given to the evaluation of AuNRs/AC-HA light-induced heat generation and drug delivery performances under near-infrared (NIR) laser irradiation in vitro. Spatiotemporal thermal profiles and high-resolution thermal maps are registered using fiber Bragg grating (FBG) sensor arrays, enabling accurate probing of maximum internal temperature variations within the composite matrix. Lastly, using a high-steric-hindrance protein (BSA) as a drug mimetic, we demonstrate that moderate localized heating under short-time repeated NIR exposure enhances the release from the nanocomposite hydrogel. Full article
(This article belongs to the Special Issue Hydrogels for Tissue Repair: Innovations and Applications)
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15 pages, 2703 KB  
Article
Fabrication and Plasmonic Characterization of Metasurfaces Patterned via Tunable Pyramidal Interference Lithography
by Saim Bokhari, Yazan Bdour and Ribal Georges Sabat
Micromachines 2026, 17(1), 104; https://doi.org/10.3390/mi17010104 - 13 Jan 2026
Viewed by 285
Abstract
Large-area metasurfaces were fabricated via a tunable pyramidal interference lithography (PIL) technique, which uses custom-built 2-faced, 3-faced, and 4-faced pyramidal prisms to create metasurfaces with customizable nano- and micro-scale surface feature periodicities. The 2-faced prism produced linear surface relief diffraction gratings, while the [...] Read more.
Large-area metasurfaces were fabricated via a tunable pyramidal interference lithography (PIL) technique, which uses custom-built 2-faced, 3-faced, and 4-faced pyramidal prisms to create metasurfaces with customizable nano- and micro-scale surface feature periodicities. The 2-faced prism produced linear surface relief diffraction gratings, while the 3-faced prism produced metasurfaces with triangular lattices and the 4-faced prism produced metasurfaces with square lattices, all on azobenzene thin films. A double inline prism set-up enabled control over the metasurface feature periodicity, allowing systematic increase in the pattern size. Additional tunability was achieved by placing a prism inline with a lens, allowing precise control over the metasurface feature periodicity. A theoretical model was derived and successfully matched to the experimental results. The resulting metasurfaces were coated with gold and exhibited distinct surface plasmon resonance (SPR) and surface plasmon resonance imaging (SPRi) responses, confirming their functionality. Overall, this work establishes PIL as a cost-effective and highly adaptable metasurface fabrication method for producing customizable periodic metasurfaces for photonic, plasmonic, and sensing applications. Full article
(This article belongs to the Special Issue Metasurface-Based Devices and Systems)
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10 pages, 2349 KB  
Article
Long Period Grating Modified with Quasi-2D Perovskite/PAN Hybrid Nanofibers for Relative Humidity Measurement
by Dingyi Feng, Changjiang Zhang, Syed Irshad Haider, Jing Tian, Jiandong Wu, Fu Liu and Biqiang Jiang
Nanomaterials 2026, 16(2), 99; https://doi.org/10.3390/nano16020099 - 12 Jan 2026
Cited by 1 | Viewed by 260 | Correction
Abstract
Metal halide perovskites have emerged as promising photoactive materials for highly efficient photodetectors; however, the inherent instability of perovskite materials in oxygen and moisture limits their practical applications. In this study, the highly moisture-sensitive characteristics of the quasi-2D perovskite nanocrystals were used to [...] Read more.
Metal halide perovskites have emerged as promising photoactive materials for highly efficient photodetectors; however, the inherent instability of perovskite materials in oxygen and moisture limits their practical applications. In this study, the highly moisture-sensitive characteristics of the quasi-2D perovskite nanocrystals were used to fabricate a long-period grating (LPG) humidity sensor based on the perovskite/polyacrylonitrile (PAN) hybrid nanofibers film. The pure-bromide quasi-2D perovskite nanocrystals were in situ synthesized and encapsulated in the PAN matrix on the fiber grating via an electrospinning technique. Humidity-induced variation in the complex permittivity of perovskites can alter the evanescent field of the co-propagating cladding modes, resulting in changes in both resonant amplitude and wavelength in the transmission spectrum of the LPG. These effects yielded an intensity sensitivity of ~0.21 dB/%RH and a wavelength sensitivity of ~18.2 pm/%RH, respectively, in the relative humidity range of 50–80%RH. The proposed LPG sensor demonstrated a good performance, indicating its potential application in the humidity-sensing field. Full article
(This article belongs to the Special Issue Nanomaterials for Optical Fiber Sensing)
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18 pages, 5762 KB  
Article
Intrinsically Safe Optical Fiber Hydrogen Sensor Using Pt-SiO2 Coated Long-Period Fiber Grating
by Xuhui Zhang, Liang Guo, Xinran Wei, Fangzhou Mao, Yuzhang Liang, Junsheng Wang and Wei Peng
Nanomaterials 2026, 16(2), 95; https://doi.org/10.3390/nano16020095 - 12 Jan 2026
Viewed by 204
Abstract
Hydrogen, a promising clean energy carrier, needs safe detection due to its flammability. Conventional electrical hydrogen sensors have drawbacks like high operating temperatures, poor selectivity and ignition risks. We propose an optical sensor using long-period fiber gratings (LPGs) coated with Pt-SiO2 nanomaterials. [...] Read more.
Hydrogen, a promising clean energy carrier, needs safe detection due to its flammability. Conventional electrical hydrogen sensors have drawbacks like high operating temperatures, poor selectivity and ignition risks. We propose an optical sensor using long-period fiber gratings (LPGs) coated with Pt-SiO2 nanomaterials. It works via catalytic reaction: H2 reacts with O2 on Pt nanoparticles, releasing heat that shifts LPG’s resonant wavelength. Structural characterization showed porous SiO2 with uniform Pt, ensuring efficiency and stability. Experiments proved it sensitively responds to 0.5–2.5% H2 (max wavelength shift 7.544 nm), with fast response/recovery, good repeatability/reversibility. Logistic fitting (R2 = 0.999) confirmed strong correlation. This sensor, safe, sensitive and stable, has great potential for real-time H2 monitoring in critical environments. Full article
(This article belongs to the Special Issue Advanced Low-Dimensional Materials for Sensing Applications)
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14 pages, 1968 KB  
Article
Multispectral Camouflage Photonic Structure for Visible–IR–LiDAR Bands with Radiative Cooling
by Lehong Huang, Yuting Gao, Bo Peng and Caiwen Ma
Photonics 2026, 13(1), 31; https://doi.org/10.3390/photonics13010031 - 30 Dec 2025
Viewed by 278
Abstract
The rapid development of detection technologies has increased the demand for multispectral camouflage materials capable of broadband concealment and effective thermal management. To address the conflicting optical requirements between infrared camouflage and LiDAR camouflage, we propose a composite design combining a germanium–ytterbium fluoride [...] Read more.
The rapid development of detection technologies has increased the demand for multispectral camouflage materials capable of broadband concealment and effective thermal management. To address the conflicting optical requirements between infrared camouflage and LiDAR camouflage, we propose a composite design combining a germanium–ytterbium fluoride (Ge/YbF3) selective emitter with an amorphous silicon (a-Si) two-dimensional periodic microstructure. The multilayer film, optimized using the transfer-matrix method and a particle swarm optimisation algorithm, achieves low emissivity in the 3–5 μm and 8–14 μm infrared atmospheric windows and high emissivity within 5–8 μm for radiative cooling, while introducing a narrowband absorption peak at 1.55 μm. Additionally, the a-Si microstructure provides strong narrowband absorption at 10.6 μm via a grating-resonance mechanism. FDTD simulations confirm low emissivity in the infrared windows, high absorptance at LiDAR wavelengths, and good angular and polarization robustness. This work demonstrates a multifunctional photonic structure capable of integrating infrared camouflage, laser camouflage, and thermal-radiation control. Full article
(This article belongs to the Section Optoelectronics and Optical Materials)
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12 pages, 5567 KB  
Article
A Long-Period Grating Based on Double-Clad Fiber for Multi-Parameter Sensing
by Wenchao Li, Hongye Wang, Xinyan Ze, Shuqin Wang, Xiangwei Hao, Yan Bai, Shuanglong Cui, Jian Xing and Xuelan He
Photonics 2025, 12(12), 1235; https://doi.org/10.3390/photonics12121235 - 17 Dec 2025
Viewed by 315
Abstract
This paper proposes a long-period grating (LPG) based on double-clad fibers (DCFs) for multi-parameter sensing. The sensor consists of cascaded-input single-mode fibers (SMF), DCF, and output SMF. Multi-parameter detection is realized by utilizing the different sensing characteristics of the resonance peak under different [...] Read more.
This paper proposes a long-period grating (LPG) based on double-clad fibers (DCFs) for multi-parameter sensing. The sensor consists of cascaded-input single-mode fibers (SMF), DCF, and output SMF. Multi-parameter detection is realized by utilizing the different sensing characteristics of the resonance peak under different physical parameters. The experiment results show that within the temperature range of 30–100 °C, the maximum sensitivity is 66.37 pm/°C. For the refractive index (RI) measurement, the tested range is 1.3309–1.3888 and the maximum sensitivity is −45.84 nm/RIU. Regarding curvature detection, the tested range is 0.6928–1.6971 m−1 and the maximum sensitivity is −2.022 nm/m−1. In addition, the sensor has a symmetrical structure, so its measurement is not restricted by the incident direction of light, thus having flexibility in practical use. This research not only contributes to the advancement of optical fiber sensor technology but also has significant implications for practical applications in industry, the environment, and healthcare. Full article
(This article belongs to the Special Issue Advances in Optical Fiber Sensing Technology)
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14 pages, 4136 KB  
Article
Tuning Surface-Enhanced Raman Scattering (SERS) via Filling Fraction and Period in Gold-Coated Bullseye Gratings
by Ziqi Li, Yaming Cheng, Carlos Fernandes, Xiaolu Wang and Harry E. Ruda
Nanomaterials 2025, 15(24), 1863; https://doi.org/10.3390/nano15241863 - 11 Dec 2025
Cited by 1 | Viewed by 565
Abstract
Surface-enhanced Raman scattering (SERS) is a highly sensitive analytical technique capable of single-molecule detection, yet its performance strongly depends on the underlying plasmonic architecture. In this study, we developed a robust SERS platform based on long-range–ordered bullseye plasmonic nano-gratings with tunable period and [...] Read more.
Surface-enhanced Raman scattering (SERS) is a highly sensitive analytical technique capable of single-molecule detection, yet its performance strongly depends on the underlying plasmonic architecture. In this study, we developed a robust SERS platform based on long-range–ordered bullseye plasmonic nano-gratings with tunable period and filling fraction, fabricated via electron beam lithography and reactive ion etching and uniformly coated with a thin gold film. These concentric nanostructures support efficient surface plasmon resonance and radial SPP focusing, enabling intense electromagnetic field enhancement across the substrate. Using this platform, we achieved quantitative detection of Rhodamine 6G with enhancement factors of 105. Notably, our results reveal a previously unrecognized mechanistic insight: the geometric configuration producing the strongest local electric fields does not yield the highest SERS enhancement, due to misalignment between the dominant field orientation and the molecular polarizability tensor. This finding explains the non-monotonic dependence of SERS performance on grating geometry and introduces a new design principle in which both field strength and field–molecule alignment must be co-optimized. Overall, this work provides a mechanistic framework for rationally engineering plasmonic substrates for sensitive and quantitative molecular detection. Full article
(This article belongs to the Section Nanophotonics Materials and Devices)
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36 pages, 4430 KB  
Review
Emerging Trends in Optical Fiber Biosensing for Non-Invasive Biomedical Analysis
by Sajjad Mortazavi, Somayeh Makouei, Karim Abbasian and Sebelan Danishvar
Photonics 2025, 12(12), 1202; https://doi.org/10.3390/photonics12121202 - 5 Dec 2025
Cited by 1 | Viewed by 788
Abstract
Optical fiber biosensors have evolved into powerful tools for non-invasive biomedical analysis. While foundational principles are well-established, recent years have marked a paradigm shift, driven by advancements in nanomaterials, fabrication techniques, and data processing. This review provides a focused overview of these emerging [...] Read more.
Optical fiber biosensors have evolved into powerful tools for non-invasive biomedical analysis. While foundational principles are well-established, recent years have marked a paradigm shift, driven by advancements in nanomaterials, fabrication techniques, and data processing. This review provides a focused overview of these emerging trends, critically analyzing the innovations that distinguish the current generation of optical fiber biosensors from their predecessors. We begin with a concise summary of fundamental sensing principles, including Surface Plasmon Resonance (SPR) and Fiber Bragg Gratings (FBGs), before delving into the latest breakthroughs. Key areas of focus include integrating novel 2D materials and nanostructures to dramatically enhance sensitivity and advancing synergy with Lab-on-a-Chip (LOC) platforms. A significant portion of this review is dedicated to the rapid expansion of clinical applications, particularly in early cancer detection, infectious disease diagnostics, and continuous glucose monitoring. We highlight the pivotal trend towards wearable and in vivo sensors and explore the transformative role of artificial intelligence (AI) and machine learning (ML) in processing complex sensor data to improve diagnostic accuracy. Finally, we address the persistent challenges—biocompatibility, long-term stability, and scalable manufacturing—that must be overcome for widespread clinical adoption and commercialization, offering a forward-looking perspective on the future of this dynamic field. Full article
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22 pages, 3271 KB  
Article
Mechanical FBG-Based Sensor for Leak Detection in Pressurized Pipes: Design, Modal Tuning, and Validation
by Beatriz Defez, Javier Madrigal, Salvador Sales and Jorge Gosalbez
Sensors 2025, 25(23), 7260; https://doi.org/10.3390/s25237260 - 28 Nov 2025
Viewed by 570
Abstract
This study presents the design, modeling, and experimental validation of a frequency-tuned mechanical sensor (MS) integrating a fiber bragg grating (FBG) for the detection of leak-induced vibrations in pressurized steel pipelines. Unlike conventional bonded FBGs—which directly follow the local wall deformation—the proposed MS [...] Read more.
This study presents the design, modeling, and experimental validation of a frequency-tuned mechanical sensor (MS) integrating a fiber bragg grating (FBG) for the detection of leak-induced vibrations in pressurized steel pipelines. Unlike conventional bonded FBGs—which directly follow the local wall deformation—the proposed MS consists of a base-fiber-mass transducer geometrically tuned so that its natural frequencies coincide with the dominant vibration modes of the pipe in the 5–7 kHz range. A combined framework of finite element analysis (FEA), computational fluid dynamics (CFD), and laboratory measurements was developed to assess the coupling between the pipe and the sensor. Results show that the MS behaves as a selective mechanical amplifier, enhancing strain sensitivity and signal-to-noise ratio (SNR) by up to 15 dB compared to a directly bonded FBG. The workflow integrates modal tuning, an equivalent harmonic excitation derived from CFD-based pressure fields, and frequency–response validation, leading to a mechanically optimized FBG transducer capable of discriminating high-frequency leak signatures. The excellent agreement between the simulation and experiment confirms that geometric resonance coupling provides an effective route to amplify leak-induced strain, offering a compact, scalable, and high-sensitivity solution for vibration-based leak detection in industrial pipelines. Full article
(This article belongs to the Section Sensors Development)
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10 pages, 3281 KB  
Article
Multi-Peak Narrowband Perfect Absorber Based on the Strong Coupling Between Fabry–Perot Mode and SPP Waveguide Mode
by Yusheng Zhai, Weiji He and Qian Chen
Photonics 2025, 12(11), 1131; https://doi.org/10.3390/photonics12111131 - 15 Nov 2025
Viewed by 469
Abstract
Plasmonic- or metamaterial-based multi-narrowband perfect absorbers hold significant potential applications in filtering, photodetection, and spectroscopic sensing. However, it is rather challenging to realize multi-peak and narrowband absorption simultaneously only using plasmonic metallic materials due to the single or dual resonance and large optical [...] Read more.
Plasmonic- or metamaterial-based multi-narrowband perfect absorbers hold significant potential applications in filtering, photodetection, and spectroscopic sensing. However, it is rather challenging to realize multi-peak and narrowband absorption simultaneously only using plasmonic metallic materials due to the single or dual resonance and large optical losses in the metallic nanostructure. Here, we numerically demonstrate a new multi-narrowband perfect absorber based on the strong coupling between the Fabry–Perot cavity modes and the surface plasmon polariton waveguide modes in a nanostructure consisting of periodic Ag grating and Ag film separated by a SiO2 waveguide layer. Six absorption peaks, an ultranarrow absorption resonance with FWHM as narrow as 8 nm, and an absorption peak amplitude surpassing 95% have been achieved. Furthermore, the optical properties of the designed nanostructures can be precisely tuned by modulating the grating period, slit width, height, as well as the thickness and refractive index of the waveguide layer. This approach establishes a versatile platform for designing high performance multi-narrowband absorbers, with promising applications in optical filters, nonlinear optics, and biosensors. Full article
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12 pages, 4901 KB  
Article
Tunable Unidirectional Guided Resonances in Momentum Space via a Si-Ge2Sb2Te5 Metasurface
by Zhi-Yuan Zheng and Ying Yu
Photonics 2025, 12(11), 1121; https://doi.org/10.3390/photonics12111121 - 13 Nov 2025
Viewed by 616
Abstract
Unidirectional guided resonances (UGRs) in periodic metasurfaces have recently attracted research interest because of their ability to achieve unidirectional radiation in all-dielectric structures without metal reflectors, which offers new possibilities for efficient grating couplers and unidirectional lasers. Here, we propose a hybrid metasurface [...] Read more.
Unidirectional guided resonances (UGRs) in periodic metasurfaces have recently attracted research interest because of their ability to achieve unidirectional radiation in all-dielectric structures without metal reflectors, which offers new possibilities for efficient grating couplers and unidirectional lasers. Here, we propose a hybrid metasurface consisting of silicon and Ge2Sb2Te5 (GST) phase change material for controlled UGR generation in the mid-infrared region. Leveraging GST’s phase-change properties to modulate the optical response of the metasurface, we achieve tunable generation of the UGR, which is demonstrated to carry a topological charge of +1. Moreover, by adjusting the degree of GST phase transition, continuous tuning of the radiation asymmetry ratio from 104 to 1 is achieved for a specific in-plane momentum and operating wavelength. These findings offer a promising avenue for dynamically controllable UGRs, with potential applications in tunable on-chip optical couplers and light sources. Full article
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29 pages, 7280 KB  
Review
Recent Advanced Photodetectors Coupling Optical Structure
by Yangye Lin and Shuo Zhang
Photonics 2025, 12(11), 1096; https://doi.org/10.3390/photonics12111096 - 7 Nov 2025
Viewed by 3491
Abstract
Photodetectors are critical components in a wide range of applications, including military, communications, medical, and aerospace fields. With ongoing advancements in optoelectronics, the strategy of integrating multiple optical structures with photodetectors has led to substantial improvements in detection performance. This review summarizes recent [...] Read more.
Photodetectors are critical components in a wide range of applications, including military, communications, medical, and aerospace fields. With ongoing advancements in optoelectronics, the strategy of integrating multiple optical structures with photodetectors has led to substantial improvements in detection performance. This review summarizes recent research progress in optically coupled photodetectors, providing a systematic analysis of the operational mechanisms and performance characteristics of five key coupling configurations: optical waveguides, surface plasmon resonance structures, microcavities, gratings, and integrated metasurfaces. Furthermore, the main limitations of current coupling technologies and challenges facing the development of future coupled devices are discussed. Recent studies indicate that heterogeneous integration, multi-physical field coupling, and automated fabrication processes are paving the way for high-performance photodetectors with enhanced bandwidth, sensitivity, functional integration, and spectral control capabilities. Full article
(This article belongs to the Special Issue Organic Photodetectors, Displays, and Upconverters)
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15 pages, 2330 KB  
Article
Handheld Lab-on-a-Chip System for Label-Free Dual-Plex Detection of Biomarkers Through On-Chip Plasma Separation
by Chen-Yuan Chang, Yuan-Pei Lei, Chien Chieh Chiang and Cheng-Sheng Huang
Biosensors 2025, 15(11), 743; https://doi.org/10.3390/bios15110743 - 4 Nov 2025
Viewed by 773
Abstract
Rapid and reliable detection of biomarkers in complex fluids such as whole blood is essential for effective disease diagnosis and monitoring, particularly in point-of-care settings. Accordingly, this study developed a handheld lab-on-a-chip (LOC) platform that integrates on-chip plasma separation with label-free optical biosensing [...] Read more.
Rapid and reliable detection of biomarkers in complex fluids such as whole blood is essential for effective disease diagnosis and monitoring, particularly in point-of-care settings. Accordingly, this study developed a handheld lab-on-a-chip (LOC) platform that integrates on-chip plasma separation with label-free optical biosensing for real-time, dual-plex detection of biomarkers. The LOC platform includes a two-stage filtration unit that enables efficient separation of plasma from whole blood. This platform also includes a novel gradient grating period guided-mode resonance sensor array that is capable of simultaneously detecting multiple biomarkers with high sensitivity. A compact handheld reader was developed to acquire and analyze optical signals. By using creatinine and albumin as model biomarkers, we demonstrated that the developed platform could achieve sensitive, specific, and reproducible biomarker detection in both plasma and whole-blood samples. The platform can detect albumin and creatinine at concentrations as low as 0.8 and 1.44 μg/mL, respectively, and it exhibits minimal nonspecific binding. These results highlight the potential of the proposed system as a robust and accessible tool for decentralized diagnostics. Full article
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