Search Results (1,264)

Climate change is intensifying water scarcity in the Mediterranean region, placing the Antalya province of Türkiye at significant risk due to declining water availability, rapid population growth, and intense tourism activities which increase seasonal demand. This study forecasts population and urban water demand until 2050 and evaluates several water loss reduction scenarios for the city’s drinking water distribution network. In developing the forecasted water demand, the analysis incorporates several water loss reduction scenarios. These include a baseline scenario maintaining current water loss levels, a moderate improvement scenario aligned with Türkiye’s national regulatory targets, and an advanced scenario achieving international best practices. Results show that reducing water losses, caused mainly by aging infrastructure, pressure fluctuations, and leaks, can substantially decrease total water demand. Improved network efficiency is therefore essential for maintaining long-term water security and supporting climate change adaptation efforts in Antalya. Full article

With intensifying measures related to investor and policy requirements, corporate governance and sectoral environmental performance became a focal point for sustainability disclosure, especially in energy-intensive industries with high environmental externalities. This study evaluates whether corporate environmental governance practices in key sectors correspond to their pollution intensity and economic output, analysing a panel dataset across EU member states, for the 2000–2021 period. The empirical methodology includes ordinary least squares (OLS), fixed- and random-effects models, and dynamic system generalised method of moments (GMM) panel estimation to account for sectoral heterogeneity. Results prove that sectoral value added is an influential factor of greenhouse gas emissions, with carbon dioxide exhibiting the highest elasticity to economic activity, followed by methane emissions, and nitrous oxide displaying cross-country variations due to structural and regulatory differences. While services and manufacturing sectors partially decouple via cleaner technologies, overall growth positively correlates with emissions, and renewable energy offers limited mitigation due to scale and integration challenges. Conclusions emphasise robust governance frameworks in high-value energy sectors to meet EU climate-neutrality goals, as stronger environmental accountability attracts capital and supports sustainable development, underscoring the needs for targeted decarbonisation, regulatory coordination, and accelerated technological innovation within persistent industry disparities. Full article

For over 70 years, microalgae have been considered promising ingredients for developing sustainable, nutritionally rich foods. Their high protein content, presence of essential amino acids, fatty acids, natural pigments, and a myriad of bioactive compounds position them as potential alternatives to conventional ingredient sources. However, despite their significant potential, the large-scale incorporation of microalgae into food products remains limited. This study presents a critical analysis of the main challenges associated with the use of microalgae in the food industry. Key bottlenecks include high production costs, technological difficulties related to biomass processing, and challenges in extracting desirable compounds. Additionally, the strong flavor, odor, and intense coloration of microalgal biomass can negatively affect sensory acceptance in food products. Other limitations involve scalability issues in cultivation systems, risks of contamination during production, and regulatory constraints related to food safety approval. Consumer perception and limited familiarity with microalgae-based foods also contribute to slower market adoption. Therefore, although microalgae represent a promising and sustainable food resource, overcoming technological, economic, and sensory barriers is essential for their broader integration into the food industry and for achieving successful market consolidation. Full article

Green fintech operates at the intersection of sustainable finance, digital innovation, and financial-sector risk governance. It promises to improve the allocation of capital toward environmentally sustainable activities by lowering information costs, scaling disclosure tools, automating environmental verification, and widening access to green investment products. Yet the same digital features that make green fintech attractive—speed, scalability, data intensity, platform intermediation, cross-border distribution, and algorithmic decision-making—can also transform apparently local regulatory weaknesses into broader financial-stability concerns. This article examines how regulatory risk associated with green fintech may evolve into systemic risk under conditions of market concentration, weak data governance, regulatory fragmentation, greenwashing amplification, and financial interconnectedness. It develops a mechanism-based conceptual framework rather than an econometric test. The framework connects three regulatory dimensions—regulatory clarity and scope, supervisory consistency, and innovation facilitation—with five systemic-risk transmission channels: market concentration, data and model risk, regulatory arbitrage, greenwashing amplification, and financial interconnectedness. The article draws on sustainable-finance regulation, the financial-stability literature, fintech scholarship, and official supervisory documents, including the EU Sustainable Finance Disclosure Regulation, the EU Taxonomy Regulation, the Digital Operational Resilience Act, and the ESG Ratings Regulation. The central argument is cautious but policy-relevant: green fintech does not automatically create systemic risk, but regulatory uncertainty and supervisory gaps may become systemic when they are embedded in digital infrastructures that scale quickly and are relied upon by multiple financial institutions. The article contributes to risk scholarship by shifting the analysis from compliance-level regulatory risk to transmission mechanisms through which green-finance innovation may affect market integrity and financial stability. Full article

Fire safety in high-rise buildings represents a critical challenge in the United Arab Emirates (UAE), where intensive urbanization, extreme climatic conditions, and multilayered regulatory frameworks impose unique competency demands on architects and Fire Safety Engineering (FSE) consultants. Despite this, no empirically validated competency framework exists that simultaneously addresses both professional groups and is tailored to the specificities of the UAE context. This study aimed to construct and empirically validate such a framework. A three-phase sequential exploratory mixed-method design was employed. In the first phase, a systematic literature review yielded a preliminary set of 69 competency indicators organized within a Knowledge, Skills and Attitudes (KSA) structure. In the second phase, a three-round Delphi technique with an expert panel of 18 specialists validated the set to 62 final indicators. In the third phase, importance–performance analysis (IPA) was conducted on a sample of 250 professionals actively engaged in fire safety projects across four UAE. IPA identified 16 priority competency gaps, most pronounced in digital transformation (BIM, CFD, AI; gap = 1.23), proactive client advisory competencies (gap = 1.21), and regulatory navigation and Civil Defence coordination (gap = 1.00). A counterintuitive finding emerged whereby architects systematically rated competencies higher than FSE consultants across all dimensions (all p < 0.05). Psychometric validation confirmed excellent instrument reliability (Cronbach’s Alpha > 0.95) and a theoretically consistent three-factor KSA structure explaining 70.06% of variance. The developed framework of 62 empirically validated indicators represents the first competency model of its kind for architects and FSE consultants in the Gulf Cooperation Council (GCC) region. Its findings provide a direct empirical basis for curriculum reform, Continuing Professional Development (CPD) programmes, and professional licencing standards in the UAE and across the GCC region. The study makes three original contributions: the first empirically validated UAE-specific competency framework for these professional groups; a methodological combination of Delphi, IPA, EFA, Mann–Whitney, and Kruskal–Wallis not previously applied in fire safety competency research; and empirical confirmation that 74% of indicators required original development or adaptation, demonstrating the limitations of generic international competency models in the UAE context. Full article

Major infrastructure investments alter accessibility and urban development patterns, yet their impact on housing prices varies significantly across regions. The prevailing interpretation attributes this heterogeneity to supply differences or regulatory constraints, treating land use regulations as exogenous variables. Nevertheless, even two regions with a nominally similar regulatory framework may produce substantially different outcomes in the housing market, depending on the effectiveness of rule implementation. This paper argues that this approach overlooks a critical variable: the ability of regional authorities to coordinate, regulate, permit, and implement spatial development in a predictable and timely manner. In line with this, a conceptual framework is developed, grounded in the literature on spatial and multi-level governance, in which regional institutional capacity is proposed as a potential mediator of capitalization around project milestones (announcement, funding, construction, operation), rather than as a backdrop. This capacity shapes outcomes through three interrelated dimensions: the responsiveness of supply, which depends on administrative capacity and regulatory consistency; the coherence of governance across jurisdictions within functional urban areas; and the management of land value through land value capture instruments. From this framework, testable propositions are derived regarding the intensity, timing, and spatial distribution of price effects. The study does not empirically estimate changes in housing prices, nor does it test the propositions put forward. Instead, it develops the conceptual framework and organizes the spatial and institutional units of observation required for a subsequent empirical test. The framework is specified spatially through Section A, Line 4 of the Athens Metro to organize the project’s spatial units, administrative jurisdictions, land uses, and milestones for future analysis. The contribution is threefold: conceptual, as it elevates regional institutional capacity from a contextual to an explanatory variable; theoretical, in that it bridges urban economics with the governance literature; and policy-relevant, since it repositions the reform of regional governance as a constituent element of housing policy and as a factor that may shape sustainable spatial development outcomes. Full article

Global population growth and the demand for sustainable food systems have pushed microalgae into the spotlight as promising novel food resources. They are rich in protein, omega-3 fatty acids, and bioactive pigments including astaxanthin and phycocyanin. Unlike conventional farming, microalgae cultivation can be conducted on non-arable land and may reduce direct competition with conventional food crops for land resources, depending on the production system used. Regulatory progress in China, the European Union (EU), and the United States has resulted in the authorization or approval of several microalgal species and microalgae-derived ingredients for specific food and nutritional applications, including dietary supplements, infant nutrition products, and alternative protein ingredients. Despite these advances, broader commercial adoption remains constrained by several challenges, such as off-flavors and the dark green color, high production costs from closed photobioreactors and energy-intensive downstream purification, fragmented regulatory frameworks across jurisdictions and limited long-term data on bioavailability, allergenicity, safety, and dose–response relationships for some emerging strains. This review focuses on microalgae as novel food resources, covering regulatory approvals, strain selection, high-value utilization, and market translation, synthesizes evidence on nutritional evaluation, application scenarios, and global regulatory differences, analyzes key bottlenecks, and proposes pathways to bridge fundamental research with industrial practice. It also highlights unresolved knowledge gaps to guide future research and policy. Full article

The expansion of remote work has transformed labour market conditions across the developed world, yet access to home-based work remains unequally distributed along occupational, sectoral, regional, and organisational lines. Post-pandemic evidence on the persistence of these inequalities is particularly scarce in Central and Eastern European economies, where historically low remote work prevalence, manufacturing-intensive industrial structures, and pronounced regional disparities create a distinctive structural context. Drawing on primary survey data collected from 390 employees in Slovakia in 2025, this study pursues two interrelated empirical goals: to identify the factors predicting a mismatch between the structural feasibility of working from home and its actual availability to employees, and to examine the determinants of experienced work discomfort. Binary logistic regression, multiple linear regression, and a battery of group difference tests were employed across the two analytical strands. The results reveal a pronounced capital–periphery gradient in remote work access, with employees outside the capital city facing dramatically higher odds of mismatch, and identify organisational support as the most practically actionable determinant of work discomfort. Notably, experiencing a mismatch between remote work feasibility and access was not associated with higher discomfort, a finding that challenges assumptions common in the Western European literature and points to the moderating role of contextual expectations in post-communist labour markets. The findings offer directly applicable evidence for employers seeking to reduce work-related strain through targeted support measures, and for policymakers designing regulatory frameworks to promote equitable access to flexible work arrangements across regions and sectors. Full article

Backfilling the industrial solid waste coal gangue into deep coal mine goafs for CO₂ geological sequestration is a crucial pathway to achieve the synergistic effect of pollution reduction and carbon mitigation. However, in complex deep geological environments, the chemical evolution of multiple mineral phases of coal gangue under gas–water–rock coupling effects and the carbon-controlling mechanism of residual total organic carbon (TOC) remain unclear. In this study, coal gangue from the goaf of the Xiaobaodang Coal Mine was used as the research object. Relying on a customized high-temperature and high-pressure reaction system to simulate the deep in situ environment (45 °C, 10 MPa), and combined with X-ray diffraction (XRD), total organic carbon determination, and isothermal CO₂ adsorption experiments, the geochemical mechanism by which inorganic minerals and organic residual carbon synergistically control the ultimate CO₂ adsorption potential was systematically revealed. The results show that the modification of the CO₂ adsorption potential of coal gangue by gas–water–rock reactions exhibits strong mineral phase differentiation. Systems rich in active silicates generate a large amount of secondary clay minerals through intense carbonation alteration, achieving a significant increase in micro–nano pores and absolute adsorption capacity. Systems rich in carbonates steadily release deep primary adsorption potential by widening mass transfer channels through mineral dissolution. In contrast, systems rich in primary clay minerals face an irreversible attenuation of adsorption space due to physical clogging of pore throats caused by fluid migration. Furthermore, the initial organic carbon content exerts a significant non-linear regulatory effect on the development of the micropore network. The physical adsorption sites provided by the high relative content of layered clay minerals (>41%), coupled with the interfacial enhancement effect exerted by a moderate organic carbon content (0.12~0.16%), constitute an optimal physicochemical synergistic enhancement network, which is the core geological reason for stimulating the ultimate carbon sequestration capacity of coal gangue. The results of this study not only enrich the multiphase interfacial thermodynamic theory of complex heterogeneous geological bodies but also provide solid theoretical support for the precise optimization of target areas and the long-term evaluation of carbon sinks in goaf CO₂ sequestration engineering. Full article

Thrombopoietin receptor agonists (TPO-RAs) have become central second-line treatments for children with persistent or chronic immune thrombocytopenia (ITP). Their efficacy has encouraged broad use, but difficult-to-treat patients who respond suboptimally may be exposed to repeated agent switching, prolonged treatment, or doses exceeding approved limits. This commentary uses a focused narrative approach to address whether the risk of treatment-associated marrow fibrosis should be interpreted primarily as a consequence of treatment duration or as a risk marker linked to supraphysiological treatment intensity in non-responders. A recent Haematologica report by Ma and colleagues identified clinically significant bone marrow myelofibrosis in a highly selected cohort of children with chronic ITP undergoing marrow re-evaluation after suboptimal response or loss of efficacy during TPO-RA therapy. The most relevant message is not simply that fibrosis can occur, but that it was independently associated with treatment intensification, particularly overdose and frequent switching. The biological plausibility of this association is supported by the known capacity of sustained megakaryocytic stimulation to promote local pro-fibrotic signaling and reticulin deposition. This commentary places this safety concern in the context of pediatric ITP epidemiology, current regulatory indications, expert approaches to refractory disease, and practical surveillance considerations. TPO-RAs should not be viewed as routine treatment for newly diagnosed pediatric ITP; their principal role remains in selected children with persistent or chronic disease who require second-line therapy. Failure to respond at the maximum approved dose should prompt diagnostic and therapeutic reassessment rather than automatic treatment escalation. The emerging lesson is that response-adapted therapy must also be risk-adapted therapy. Full article

Anthocyanin-rich dark pigmentation is increasingly recognized as more than a simple consequence of flavonoid accumulation. Here, we define the anthocyanin-driven dark phenotype (ADP) as a coordinated stress-responsive state characterized by intense anthocyanin accumulation coupled with cellular and regulatory reprogramming. Recent studies show that reactive oxygen species, sugar signaling, temperature stress, and hormonal crosstalk converge on MYB–bHLH–WD40-centered regulatory networks that integrate pigment biosynthesis with vacuolar organization, transport activity, and stress adaptation. Epigenetic remodeling, chromatin dynamics, and post-transcriptional regulation further influence pigment intensity and persistence. Importantly, ADPs do not represent an alternative biosynthetic pathway or merely pigment abundance, but instead reflect a systems-level regulatory state governed by coordinated transcriptional, hormonal, and epigenetic control of the canonical anthocyanin machinery. However, several important questions remain unresolved, including how plants retain phenotypic stability under various environmental and developmental settings, whether ADPs contribute to long-term stress memory, and how anthocyanin accumulation is balanced with growth and energy expenditures. To translate ADP-associated features into crop development techniques, these gaps must be filled. We also emphasize spatial omics and CRISPR-based engineering as new methods for analyzing and modifying stress-resilient phenotypes. Full article

Host genetic susceptibility to urogenital Chlamydia trachomatis (Ct) reinfection remains poorly understood. Coding variants identified in prior genome-wide association studies (GWAS) explained only a small fraction of the risk of reinfection. Our goal in this study was to characterize whether more risk would be captured by sequence variation that traditional GWAS insufficiently captures. Specifically, we evaluated the risk attributable to SNPs present in regulatory, non-coding regions; post-transcriptional regulation by microRNAs (miRNAs) that may depend on sequence variation in either the miRNA or the target mRNA; and copy number variants (CNVs). We analyzed GWAS data from African American women with or without documented urogenital Ct reinfection. Fine mapping and independent association analyses identified 30 unique index single-nucleotide polymorphisms (iSNPs), which were expanded to variants in linkage disequilibrium. Regulatory annotation was performed using HaploReg, RegulomeDB, FORGEdb, rSNPBase, and GTEx. We examined whether genes identified in the Ct reinfection GWAS are targeted by known Ct infection–associated microRNAs using curated databases. Genome-wide CNV calling was conducted using SNP intensity data, followed by stringent quality control and gene-level association testing. Functional annotation prioritized 7 SNPs with strong regulatory evidence, with stringent criteria for regulatory relevance, using HaploReg, RegulomeDB, FORGEdb, and rSNPBase. The strongest signals were observed at the CHIT1 locus, where multiple intronic variants (including rs2486963 and rs2244385) overlapped regulatory chromatin, altered transcription factor binding motifs, and acted as cis-expression quantitative trait loci for CHIT1 in whole blood. Additional regulatory variants were identified near TDRP, ERICH1, and DLGAP1, showing tissue-specific regulatory effects. MicroRNA analysis revealed extensive post-transcriptional targeting of SOCS6 and SULF1, while CHIT1 showed no curated Ct-associated miRNA interactions. CNV analysis identified 5775 high-confidence events, with nominal gene-level associations observed for ATAD3A, CARD14, TMEM240, and ZNF140. These results indicate that a greater fraction of the susceptibility to urogenital Ct reinfection may be driven by genetic variation affecting immune and epithelial pathways rather than protein-coding changes. Full article

Artificial intelligence (AI) is increasingly integrated into emergency general surgery (EGS), where rapid diagnosis, accurate decision-making, and timely intervention are essential for improving patient outcomes. Recent advances in machine learning, deep learning, computer vision, and predictive analytics have enabled AI-assisted systems to support clinicians throughout the perioperative workflow. Current applications include radiologic image interpretation, diagnosis of acute abdominal conditions, surgical workflow recognition, intraoperative anatomical guidance, postoperative complication prediction, and intensive care monitoring. AI technologies may improve diagnostic accuracy, optimize operative planning, enhance surgical safety, and facilitate personalized perioperative management. In minimally invasive surgery, computer vision and real-time data analysis have shown promising results for intraoperative decision support and surgical education. However, important limitations remain, including concerns regarding data quality, algorithm transparency, ethical governance, regulatory approval, and implementation disparities between healthcare systems. In addition, much of the current evidence is derived from retrospective or highly specialized datasets, limiting broad clinical applicability. This narrative review summarizes the current clinical applications of AI in emergency general surgery and discusses emerging technologies, existing challenges, and future perspectives regarding the integration of AI into acute surgical care. Full article

From the perspective of interactions between energy firm behavior and government intervention strategies, this study develops a contagion control model for energy firm debt default risk utilizing cellular automata and complex network theory. This research investigates the spatio-temporal evolution of risk transmission and evaluates the efficacy of various mitigation protocols through computational simulation. The research results indicate that: (1) An escalation in both the transmission likelihood and the rate of immunity decay significantly amplifies the propagation strength of debt default risks. Conversely, the stability of the energy firm network is bolstered as the probabilities of immunity and recovery increase. (2) The contagion intensity for debt default risk is positively correlated with market noise, the risk appetite of energy firms, and their corporate influence. It is negatively correlated with risk awareness, creditworthiness, regulatory intensity, and policy subsidies. Furthermore, it exhibits an inverted U-shaped relationship with investor sentiment. (3) Within the interconnected network of energy firms, risk contagion can be effectively mitigated not only by enhancing risk perception and credit standing but also by guiding risk preference and managing firm influence. Furthermore, the integration and adjustment of government intervention strategies, such as regulatory intensity and policy subsidies, can more efficiently accelerate the eradication of debt default risk among energy firms. Full article

This exploratory study investigates the application of the EU Taxonomy within the Romanian capital market, focusing on companies included in the BET Index and analyzing discrepancies between declarative sustainability commitments and actual technical compliance. Employing documentary content analysis and descriptive statistical design, the research introduces a convergence matrix that compares declarative intensity with taxonomic potential, mainly reflected through eligible turnover and complemented by CapEx-related indicators. The findings suggest a systemic execution gap. Despite significant eligibility in certain cases, technical alignment tends to remain very limited, mainly due to the bureaucratic and practical constraints involved in demonstrating compliance with the Do No Significant Harm criteria. Consequently, the analysis identifies a possible cross-sectional decoupling pattern: entities with low eligibility tend to compensate through extensive narrative disclosures, whereas those with higher eligibility maintain more pragmatic and technical communication. Furthermore, Capital Expenditure appears to be used as a forward-looking mechanism to project future transition efforts. The study concludes that, in emerging markets, the EU Taxonomy currently operates as a regulatory-technical proxy, emphasizing the need to distinguish substantive compliance from formal, narrative-driven disclosure. Full article