Search Results (49)

Background/Objectives: In this study, we present a green, scalable platform for the production of water-dispersible powders co-encapsulating the lipophilic bioactives curcumin (Cur) and eugenol (Eug) within the amphiphilic polymer Soluplus^® (SP) via low-temperature spray drying. Methods: The amount of Cur (1%, 5%, and 10%) and Eug (5%, 10%, 15%, and 20%) was varied to achieve single- and double-loaded water-soluble powders with the maximum amount of active substances. The powders containing a higher loading of Cur, 5% and 10% (and Eug), were obtained from water/ethanol mixtures (2:1 and 5:1 v/v ratio), while the formulation with 1% of Cur was spray-dried by using water as a solvent. Results: By leveraging aqueous or aqueous–ethanolic feed systems, we achieved high loading of the bioactive substances—up to 10% Cur and 20% Eug (w/w)—while minimizing organic solvent use. Myo-inositol was incorporated as a stabilizing excipient to modulate particle morphology, improve powder flowability, and enhance redispersibility. Physicochemical characterization revealed nanoscale micellization (53–127 nm), amorphization of both actives as confirmed by XRD and DSC, and the absence of crystalline residue. Encapsulation efficiencies exceeded 95% for Cur and 93% for Eug. Dissolution tests demonstrated a rapid release from the 5% Cur/5% Eug formulation (>85% in 5 min), while higher-loaded single-formulations showed progressively slower release (up to 45 min). Conclusions: This work demonstrates a robust and environmentally responsible encapsulation strategy, suitable for delivering poorly water-soluble phytochemicals with potential applications in oral nutraceuticals and pharmaceutical dosage forms. Full article

In this study, cellulose nanocrystals (CNCs) were successfully isolated through the acid hydrolysis of freeze-dried and oven-dried bacterial nanocellulose (BNC) recovered from the floating pellicle generated during Kombucha tea production. The influence of the BNC drying method and its concentration on the yield and main characteristics of the CNCs obtained were studied. Additionally, selected CNC suspensions at various pH levels were subjected to freeze-drying and oven-drying, followed by an assessment of their dispersibility in water after undergoing different mechanical treatments. Results demonstrate the potential of utilizing byproducts from the expanding Kombucha industry as an alternative cellulose source for CNC production. Furthermore, the drying method applied to the BNC and its initial concentration in the hydrolysis medium were found to significantly impact the properties of the resulting CNCs, which exhibited diverse size distributions and Z-potential values. Finally, the redispersion studies highlighted the beneficial effect of drying CNCs from neutral and alkaline dispersions, as well as the requirement of ultrasound treatments to achieve the proper dispersion of dehydrated CNC powders. Full article

This study developed a vinyl acetate-ethylene rapid repair mortar (VAE-RRM) by using a binary blended cementitious system (ordinary Portland cement and sulfoaluminate cement) and vinyl acetate-ethylene (VAE) redispersible polymer powder. The effects of the polymer-to-cement ratio (P/C: 0~2.0%) on setting time, mechanical properties, interfacial bonding, and microstructure were systematically investigated. The results reveal that VAE delayed cement hydration via physical encapsulation and chemical chelation, extending the initial setting time to 182 min at P/C = 2.0%. At the optimal P/C = 0.9%, a synergistic organic–inorganic network enhanced flexural strength (14.62 MPa at 28 d, 34.0% increase) and interfacial bonding (2.74 MPa after interface treatment), though compressive strength decreased to 65.7 MPa due to hydration inhibition. Excessive VAE (P/C ≥ 1.5%) suppressed AFt/C-S-H growth, increasing harmful pores (>1 μm) and degrading performance. Microstructural analysis via scanning electron microscopy (SEM) and mercury intrusion porosimetry (MIP) demonstrates that VAE films bridged hydration products, filled interfacial transition zones (ITZ), and refined pore structures, reducing the most probable pore size from 62.8 nm (reference) to 23.5 nm. VAE-RRM 3 (P/C = 0.9%) exhibited rapid hardening (initial setting time: 75 min), high substrate recovery (83.3%), and low porosity (<10%), offering an efficient solution for urban infrastructure repair. This work elucidates the dual mechanisms of pore refinement and interface reinforcement driven by VAE, providing theoretical guidance for designing high-performance repair materials. Full article

Objectives: Micelles, liposomes, and solid lipid nanoparticles (SLNs) are promising drug delivery vehicles; however, poor aqueous stability requires post-processing drying methods for maintaining long-term stability. The objective of this study was to compare the potential of lipid-based micelles, liposomes, and SLNs for producing stable re-dispersible spray-dried powders with trehalose or a combination of trehalose and L-leucine. This study provides novel insights into the implementation of spray drying as a technique to enhance long-term stability for these lipid-based nanocarriers. Methods: Aqueous dispersions of LDV-targeted micelles, liposomes, and SLNs loaded with paclitaxel (PTX) were converted into re-dispersible powders using spray drying. The physicochemical properties of the nanocarriers were determined via scanning electron microscopy (SEM), Karl Fischer titration, differential scanning calorimetry (DSC), and dynamic light scattering (DLS). Short-term stability of all nanocarrier formulations was compared by measuring particle size, polydispersity index (PDI), and paclitaxel retention over 7 days at room temperature and at 4 °C. Results: Paclitaxel-loaded micelles, liposomes, and SLN formulations were successfully converted into well-dispersed spray-dried powders with acceptable yields (71.5 to 83.5%), low moisture content (<2%), and high transition temperatures (95.1 to 100.8 °C). SEM images revealed differences in morphology, where nanocarriers spray-dried with trehalose or a combination of trehalose and L-leucine produced smooth or corrugated particle surfaces, respectively. Reconstituted spray-dried nanocarriers maintained their nanosize and paclitaxel content over 7 days at 4 °C. Conclusions: The results of this study demonstrate the potential for the development of spray-dried lipid-based nanocarriers for long-term stability. Full article

Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within a hydrophilic matrix, to the scope of improving local delivery and enhancing healing. Hydroxyapatite (HXA), often used as a bone substitute, was added to prevent post-extraction alveolus volume reduction. Methods: The mLNP-RSV dispersion was mixed with seven different polymers in various mLNP/polymer ratios. Following freeze-drying, the powders were redispersed, and the resulting dispersions were tested by DLS experiments. Then, the best two nanocomposites underwent extensive characterization by SEM, XRD, FTIR, Raman spectroscopy, and thermal analysis as well as in vitro partitioning studies aimed at verifying their ability to yield the mLNP-RSV from the hydrophilic matrix to a lipophilic tissue. The characterizations led to identify the best nanocomposite, which was further combined with HXA to obtain hybrid nanocomposites, further evaluated as pharmaceutical powders or in form of mini-tablets. Results: PEG-based nanocomposites emerged as optimal and, following HXA insertion, the resulting powders revealed adequate bulk properties, making them useful as a pharmaceutical intermediate to produce ≈59 mm³ mini-tablets, compliant with the post-extraction socket. Moreover, they were proven ex vivo to be able to promote RSV and GA accumulation into the buccal tissue over time. Conclusions: The here-proposed mini-tablet offers an innovative therapeutic approach for alveolar wound healing promotion as they led to a standardized dose administration, while being handy and stable in terms of physical solid identity as long as it takes to suture the wound. Full article

To address the severe damage caused by voids beneath cement concrete pavement slabs, which compromise pavement performance and lifespan, there is an urgent need to develop an economical and efficient grouting material for slab void repair. This study employed a two-step orthogonal experiment design (OED) method to optimize the composition of grouting material. Results show that the plain cement mortar achieves the best flowability, setting time, compressive strength, or flexural strength when the water-to-binder ratio is 0.375, with 20% quartz sand, 2% coal ash, and 5% ground calcium carbonate. For the high-performance cement mortar developed, the optimal water-to-binder ratio is 0.35, with 0.5% redispersible latex powder, 0.2% polypropylene fiber, 0.6% water-reducing agent, 0.8% early-strength agent, and 2.0% expansion agent. Under these optimal conditions, the grouting material with a flowability of 15 s has a compressive strength and flexural strength of 76.98 MPa and 11.89 MPa, respectively, and achieves 77.4% of its 28-day compressive strength and 94.0% of its 28-day flexural strength by day 3. This grouting material also possesses a slight expansion within 0.1% at 3, 7, and 28 days, categorizing it as a micro-expansion mortar. The bond strength at the mortar-concrete interface exceeds the tensile strength of the mortar itself, ensuring no debonding at the interface before grouting material failure. The XRD, SEM, and infrared spectra results explain the early strength development mechanism of this cement mortar. Full article

The popularity of additive technologies in construction is increasing every year. At the same time, there are still a significant number of unresolved issues in this area related to the complexity of ensuring uniformity of printing due to technical difficulties with the mortar. One of the main issues is the adhesion of printed layers. This is especially true for continuing the printing process after it has been suspended with the formation of a cold joint. The authors consider the possibility of improving the technological properties of 3D construction printing (3DCP) mortars by introducing redispersible polymer powders (RPPs) and surface-active substances (SASs) into their composition. A comprehensive analysis of the effectiveness of various RPPs and SASs was carried out using standard testing methods to identify the most effective options and combinations of admixtures depending on their structure and mechanism of action. Laboratory tests of the mortar composition for 3DCP using the selected RPPs and SASs were carried out with the imitation of the formation of a cold joint. The most effective combination of RPPs and SASs was used to create the mortar for making the form-forming element using a construction 3D printer. Based on the results of the tests, the patterns of RPPs and SASs influence on the adhesive strength of such mixtures were determined. Full article

Background. Lipid–polymer hybrid nanoparticles (LPHNPs) offer a promising method for delivering methylprednisolone (MePD) to treat lung inflammation, addressing aggregation issues seen with polymer-only formulations. Objectives. This study aimed to develop LPHNPs for MePD delivery, assessing their physicochemical properties, drug loading, cytocompatibility, and release profiles, ultimately enabling inhalable microparticle-based powder. Methods. The nanoparticles were formulated using α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-g-Rhodamine B-g-poly(lactic acid) (PHEA-g-RhB-g-PLA) and phospholipids DPPC, DOTAP, and DSPE-PEG2000 in a 45:30:25 weight ratio. Their size, redispersion after freeze-drying, drug loading (DL%), and controlled release were evaluated. Cytocompatibility was assessed on 16-HBE cell lines, measuring anti-inflammatory effects via IL-6 and IL-8 levels. Spray drying was optimized to produce microparticles using mannitol (MAN), leucine (LEU), and N-acetylcysteine (NAC). Results. The nanoparticles had a size of 186 nm and a DL% of 2.9% for MePD. They showed good cytocompatibility, significantly reducing IL-6 and IL-8 levels. Spray drying yielded microparticles with a fine particle fraction (FPF) of 62.3% and a mass median aerodynamic diameter (MMAD) of 3.9 µm. Inclusion of LPHNPs@MePD (0.25% w/v) resulted in FPF and MMAD values of 56.7% and 4.4 µm. In conclusion, this study described the production of novel inhalable powders as carriers for MePD-loaded nanostructures with favorable physicochemical properties, cytocompatibility, and promising aerosol performance, indicating their potential as an effective inhalable therapy for lung inflammation with corticosteroids, especially for treating chronic diseases. Full article

This research focuses on a mineral–cement mixture containing bitumen emulsion, designed for cold recycling procedures, the formulation of which includes 80% (m/m) of waste material. Deep cold recycling technology from the MCE mixture guarantees the implementation of a sustainable development policy in the field of road construction. The utilised waste materials include 50% (m/m) reclaimed asphalt pavement (RAP) from damaged asphalt layers and 30% (m/m) recycled aggregate (RA) sourced from the substructure. In order to assess the possibility of using a significant amount of waste materials in the composition of the mineral–cement–emulsion (MCE) mixture, it is necessary to optimise the MCE mix. Optimisation was carried out with respect to the quantity and type of binding agents, such as Portland cement (CEM), bitumen emulsion (EMU), and redispersible polymer powder (RPP). The examination of the impact of the binding agents on the physico-mechanical characteristics of the MCE blend was performed using a Box–Behnken trivalent fractional design. This method has not been used before to optimise MCE mixture composition. This is a novelty in predicting MCE mixture properties. Examinations of the physical properties, mechanical properties, resistance to the effects of climatic factors, and stiffness modulus were conducted on Marshall samples prepared in laboratory settings. Mathematical models determining the variability of the attributes under analysis in correlation with the quantity of the binding agents were determined for the properties under investigation. The MCE mixture composition was optimised through the acquired mathematical models describing the physico-mechanical characteristics, resistance to climatic factors, and rigidity modulus. The optimisation was carried out through the generalised utility function U^III. The optimisation resulted in indicating the proportional percentages of the binders, enabling the assurance of the required properties of the cold recycled mix while utilising the maximum quantity of waste materials. Full article

Cellulose in the nano regime, defined as nanocellulose, has been intensively used for water treatment. Nanocellulose can be produced in various forms, including colloidal, water redispersible powders, films, membranes, papers, hydrogels/aerogels, and three-dimensional (3D) objects. They were reported for the removal of water contaminants, e.g., heavy metals, dyes, drugs, pesticides, pharmaceuticals, microbial cells, and other pollutants from water systems. This review summarized the recent technologies for water treatment using nanocellulose-based materials. A scientometric analysis of the topic was also included. Cellulose-based materials enable the removal of water contaminants, and salts offer advanced technologies for water desalination. They are widely used as substrates, adsorbents, and catalysts. They were applied for pollutant removal via several methods such as adsorption, filtration, disinfection, coagulation/flocculation, chemical precipitation, sedimentation, filtration (e.g., ultrafiltration (UF), nanofiltration (NF)), electrofiltration (electrodialysis), ion-exchange, chelation, catalysis, and photocatalysis. Processing cellulose into commercial products enables the wide use of nanocellulose-based materials as adsorbents and catalysts. Full article

The present study compared vacuum drum drying (VDD) and conventional spray drying (SD) for solidifying crystalline ABT-199 nanosuspensions into redispersible oral drug products. The aim was to optimize formulation compositions and process conditions to maintain nanoparticle size after tablet redispersion. The impact of drug load (22%, 33%, 44%) and type of drying protectant (mannitol, mannitol/trehalose mix (1:1), trehalose) on redispersibility and material powder properties were investigated. Moreover, compression analysis was performed assessing the influence of compaction pressure on primary nanocrystal redispersibility and tablet disintegration. Higher drug loads and lower drying protectant levels resulted in particle growth, confirming a drug load dependence on redispersibility behavior. Notably, all drying protectants showed similar protection properties at properly chosen drying process parameters (T_g-dependent), except when VDD was used for mannitol formulations. Differences between the applied drying processes were observed in terms of downstream processing and tabletability: mannitol-containing formulations solidified via VDD showed an improved processability compared to formulations with trehalose. In conclusion, VDD is a promising drying technique that offers advantageous downstream processability compared to SD and represents an attractive novel processing technology for the pharmaceutical industry. As demonstrated in the present study, VDD combines higher yields with a leaner manufacturing process flow. The improved bulk properties provide enhanced tabletability and enable direct compression. Full article

Cannabigerol (CBG), a cannabinoid from Cannabis sativa L., recently attracted noteworthy attention for its dermatological applications, mainly due to its anti-inflammatory, antioxidant, and antimicrobial effectiveness similar to those of cannabidiol (CBD). In this work, based on results from studies of in vitro permeation through biomimetic membranes performed with CBG and CBD in the presence and in the absence of a randomly substituted methyl-β-cyclodextrin (MβCD), a new CBG extemporaneous emulgel (oil-in-gel emulsion) formulation was developed by spray-drying. The powder (SDE) can be easily reconstituted with purified water, leading to a product with chemical-physical and technological characteristics that are comparable to those of the starting emulgels (E). Thermogravimetric analysis (TGA), attenuated total reflection-Fourier transformed infrared spectroscopy (ATR-FTIR), x-ray powder diffraction (XRPD), and high-performance liquid chromatography (HPLC) analyses demonstrated that the spray-drying treatment did not alter the chemical properties of CBG. This product can represent a metered-dosage form for the localized treatment of cutaneous afflictions such as acne and psoriasis. Full article

Sustainable corn starch nanoparticles were prepared using media milling to stabilize omega-3-rich Pickering emulsions based on chia oil. The milling conditions were as follows: 24 h (milling time), 0.4–0.6 mm (bead diameter), 1600 rpm (impeller speed), 30% (volume occupied by the grinding media), 7% w/v (starch concentration), and 0, 0.07 and 1% w/v of sodium dodecyl sulfate (SDS). Nanosuspensions containing 7% w/v of starch and the three concentrations of SDS were filtered, centrifuged, homogenized, and spray-dried to obtain redispersible powders. The particle size ranges were 2288 ± 211, 385 ± 21, and 278 ± 11 nm with 0, 0.07 and 1% w/v of SDS, respectively. The most stable backscattering profiles obtained during a period of one week were observed with 0.07 and 1% w/v of SDS. Therefore, the surface dilatational rheology of these particles adsorbed at chia oil/water interfaces was studied. A rapid decrease in the interfacial tension within 1 h was obtained with 1% w/v of SDS (down to 3 mN/m). Moreover, the most stable particle size after redispersion was obtained with the highest concentration of SDS. Finally, Pickering emulsions were prepared, and significant coalescence was observed with 0 and 0.07% w/v of SDS (within a few minutes). Nonetheless, in the presence of 1% w/v of SDS, oil droplets showed mean diameters and polydispersity indexes of 280.13 ± 4.60 nm and 0.35 ± 0.02, respectively, with no significant variations during storage for around 1 month. The results show that wet-stirred media milling can be applied to produce sustainable, new food-grade starch nanoparticles able to deliver bioactive compounds from chia oil. Full article

This study entailed performance tests to confirm the bond performance of the proposed new repair material and the pressurization effect of the developed mechanical pressurizing equipment. The physical property changes of the new repair material were reviewed by varying the mixing ratio of high aluminate cement (HAC)-mixed mortar. Strength tests were performed according to the mixing ratios of polymer and silica fume to improve the bond performance. To improve water retention, the mixing ratios of the cellulose and nylon fibers were adjusted, and the change in water retention was measured. The proposed repair material mixing ratio yielded the best performance when pressure was applied to the repair surface. Comparing the existing repair materials and the new repair material prepared by adjusting the ratios of HAC-mixed mortar, cellulose fiber, redispersible powder resin, and other factors confirmed that the new repair material has a high bond strength. Full article

The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors. To this end, we designed and assessed the quality of a multiparticulate reconstitutable suspension powder containing fixed dose rifampicin and pyrazinamide (150 mg/300 mg per 5 mL) which was prepared employing solid–liquid direct dispersion coupled with timed dehydration, and mechanical pulverization. The optimized formulation had a high production yield (96.000 ± 3.270%), displayed noteworthy powder flow quality (9.670 ± 1.150°), upon reconstitution the suspension flow property was non-Newtonian and was easily redispersible with gentle manual agitation (1.720 ± 0.011 strokes/second). Effective drug loading was attained for both pyrazinamide (97.230 ± 2.570%w/w) and rifampicin (97.610 ± 0.020%w/w) and drug release followed a zero-order kinetic model (R² = 0.990) for both drugs. Microscopic examinations confirmed drug encapsulation efficiency and showed that the particulates were micro-dimensional in nature (n < 700.000 µm). The formulation was physicochemically stable with no chemically irreversible drug-excipient interactions based on the results of characterization experiments performed. Findings from organoleptic evaluations generated an overall rating of 4.000 ± 0.000 for its attractive appearance and colour 5.000 ± 0.000 confirming its excellent taste and extremely pleasant smell. Preliminary cytotoxicity studies showed a cell viability above 70.000% which indicates that the FDC formulation was biocompatible. The optimized formulation was environmentally stable either as a dry powder or reconstituted suspension. Accordingly, a stable and palatable FDC antimycobacterial reconstitutable oral suspension powder, intended for flexible dosing in children and adolescents, was optimally fabricated. Full article