Search Results (755)

Aviation safety depends critically on pilots’ mental and cognitive states, particularly in high-stakes and complex operational environments where human errors cause most safety events today. This paper reviews current advances in real-time monitoring of commercial pilots’ cognitive states through physiological and neurophysiological signals and identifies methods applicable to enhance aviation safety and efficiency. In an increasingly complex and congested system, it is essential to investigate the relationships between pilots’ mental workload, stress, startle effect, and physiological parameters to highlight cognitive overload or deficiencies in real time. This systematic literature review was conducted according to PRISMA 2020 guidelines, using Google Scholar, Scopus, and PubMed, and identified 26 eligible studies. A targeted backward citation search screened 17 additional records, and two studies were added to the initial set. Twenty-eight records were therefore included and the review highlights a range of biometric indicators of pilots’ mental states with varying degrees of validity and operational applicability. Collectively, these studies offer a clear overview of state-of-the-art approaches, while also evidencing constraints related to intrusiveness and real-world feasibility. Physiological monitoring holds strong promise for enhancing pilot performance and safety by detecting early signs of overload and stress. However, its integration into operational aviation remains limited. Future research should prioritise longitudinal, in situ evaluations, multimodal data fusion, and pilot-centred design to ensure practical applicability, non-intrusiveness, and regulatory compliance, ultimately bridging the gap between academic research and cockpit reality. Full article

Background: Μetabolic syndrome (MetS)—comprises central adiposity, elevated blood pressure, dyslipidaemia, and dysglycaemia, increasing the risk of type 2 diabetes and cardiovascular disease. Exercise training improves cardiorespiratory fitness and several MetS components, but real-world effectiveness is limited by poor adherence, restricted supervision, and insufficient personalisation. Objective: This scoping review mapped the clinical intervention evidence on technology-enhanced exercise and structured physical activity relevant to MetS, while distinguishing direct MetS evidence from translational evidence. Methods: In accordance with PRISMA-ScR, we searched PubMed and extended the search to Scopus and Web of Science; a supplementary IEEE Xplore search and a post hoc Embase check were also conducted. Eligible studies were interventions using web-based delivery, wearables, telemonitoring/mobile health (mHealth), artificial intelligence (AI) coaching, virtual reality (VR)/exergaming, or continuous glucose monitoring (CGM) alongside exercise training or structured physical activity. Results: Nineteen studies met the eligibility criteria. The evidence base was weighted toward wearable/app-based feedback and telemonitoring/mHealth/web-based approaches, with fewer studies on VR/exergaming, CGM-enabled exercise, and AI coaching. Most studies were randomised or cluster-randomised, but interventions were usually short term. Across categories, technology most consistently supported adherence, self-monitoring, accountability, remote supervision, and, in selected cases, physiology-informed personalisation. Direct MetS evidence was strongest for wearables with structured feedback, telemonitoring, mHealth, and web-based delivery, whereas AI coaching and CGM were supported by adjacent translational evidence. Conclusions: Technology-enhanced exercise and structured physical activity show promising but heterogeneous and still preliminary potential for MetS management. Key limitations include short follow-up, uneven representation across categories, inconsistent reporting of exercise dose/intensity fidelity and adverse events, and limited equity and implementation outcomes. Full article

The emergence of classicality through quantum decoherence is commonly described from complementary perspectives emphasizing stability (environment-induced superselection), objectivity (Quantum Darwinism), or physical feasibility (information thermodynamics). In realistic open quantum systems, however, these aspects coexist and compete under finite physical resources. In this work we argue that classical structure selection is most naturally understood as a resource-constrained, multi-objective process. We introduce the Informational Economy Functional (IEF), an effective accounting framework that places loss of distinguishability, energetic dissipation, and the generation of redundantly accessible records on equal footing. The associated Principle of Informational Economy characterizes emergent classical structures as those achieving an optimal compromise among stability, objectivity, and energetic feasibility. Classicality is thus neither maximally stable, nor maximally redundant, nor maximally energy-efficient, but instead reflects a Pareto-optimal balance shaped by environmental constraints. The IEF yields falsifiable predictions concerning pointer-structure variability, redundancy deformation, and resource-sensitive trade-offs, and suggests concrete experimental tests in continuously monitored quantum platforms. Classical reality is thereby reinterpreted as the most economical configuration in which information can stably form, propagate, and persist. Full article

The Spur-thighed tortoise (Testudo graeca) is a long-lived terrestrial reptile listed as ‘Vulnerable’ on the IUCN Red List and protected under CITES Appendix II. As an ecosystem engineer, it plays a vital role in Mediterranean landscapes, yet it frequently faces anthropogenic pressures in urban environments. This study provides an ecological and ethological assessment of a captive T. graeca population (n = 42) in the historical Münire Madrasa Handicrafts Bazaar in Kastamonu, Türkiye. The methodology integrated spatial carrying capacity modeling (Boullon model), systematic ethogram-based observations (120 h), and ethnozoological surveys (n = 200). Spatial analysis revealed that the population exceeds the corrected Real Carrying Capacity (RCC ≈ 10) by four times (Overcapacity Index: 4.2) within the 70 m² area. Ethological findings documented chronic stress, with stereotypic pacing (H1) occupying 32% of the time budget, alongside a significant loss of anti-predator mechanisms due to anthropogenic habituation (İ1). While stakeholders (100%, 95% CI: 98.1–100%) perceive the tortoises as cultural symbols of abundance, the biological reality indicates severe welfare risks, including potential metabolic bone disease from a monotonous anthropogenic diet and a disrupted Ca:P ratio. The site is categorized as a ‘High-Constraint Interaction Zone’. We propose a management transition toward a monitored ‘Urban Wildlife Education Station’ to align local cultural values with international animal welfare and conservation standards. Full article

Telerehabilitation—the remote delivery of rehabilitation services—is undergoing a paradigm shift with the convergence of immersive virtual reality (VR) and wearable biosensor technologies. This perspective article outlines a vision for home-based motor and cognitive rehabilitation that is engaging, personalized, and data-driven. We describe how immersive VR environments (for example, simulations of home settings or supermarkets) coupled with wearable sensors can address current challenges in rehabilitation by increasing patient motivation, enabling real-time biofeedback, and supporting remote clinician supervision. Gamification mechanisms and rich sensory feedback in VR are highlighted as key strategies to enhance user engagement and adherence to therapy. We discuss conceptual innovations such as multi-sensor data integration, dynamic difficulty adaptation, and AI-driven personalization of exercises, derived from recent research and our development experience, and consider their potential benefits for patients with neuro-cognitive-motor impairments (e.g., stroke, Parkinson’s disease, and multiple sclerosis). Implementation scenarios for home-based therapy are presented, emphasizing scalability, standardized digital metrics for monitoring progress, and seamless involvement of clinicians via telehealth platforms. We also critically examine the current limitations of VR and telehealth rehabilitation and how an integrative model could overcome these barriers. More specifically, this perspective defines the engineering requirements of a closed-loop VR-based telerehabilitation framework, including multimodal data synchronization, calibration, signal-quality management, interpretable adaptive control, digital biomarker validation, and practical strategies to improve accessibility, privacy, and scalability in home-based neurological rehabilitation. Full article

Calcium–silicate–hydrate (C-S-H), the primary binding phase governing cement paste cohesion, undergoes progressive physicochemical transformation upon carbonation—a process that critically dictates concrete durability in atmospheric environments. When CO₂ penetrates the porous cement matrix, it triggers a cascade of degradation mechanisms: calcium leaching decalcifies the C-S-H structure, inducing polymerization of silicate chains from dimeric to longer-chain configurations, while concurrent precipitation of calcium carbonate and amorphous silica gel fundamentally reconstitutes the nanoscale architecture. These nanoscale alterations propagate to macroscopic property evolution, manifesting as initial strength and stiffness gains due to pore-filling carbonation products followed by eventual deterioration as the cohesive binding network deteriorates. This review synthesizes current understanding of carbonation-induced structural evolution, examining the coupled influences of environmental parameters—CO₂ concentration, relative humidity, and temperature—alongside C-S-H intrinsic chemistry (Ca/Si ratio, aluminum substitution, and alkali content) on reaction kinetics and material performance. However, significant knowledge gaps persist: predictive models for in-service carbonation rates remain elusive due to the disconnect between idealized laboratory conditions and the heterogeneous, cracked reality of field concrete; the causal linkage between nanoscale C-S-H alteration and macroscale cracking patterns along with physical performance is poorly resolved, and most mechanistic studies rely on synthetic C-S-H, neglecting the compositional complexity of real Portland cement systems. We further propose emerging protection strategies, including surface barrier coatings and low-carbon alternative binders (geopolymers, calcium sulfoaluminate cements, carbon-negative materials such as recycled cement), which demonstrate enhanced carbonation resistance. Future research priorities include developing effective coating barriers for carbonation protection, developing operando characterization techniques for real-time reaction monitoring, deploying machine learning algorithms to bridge atomistic simulations with structural-scale predictions, and establishing long-term field performance databases to validate laboratory-derived degradation models. Full article

Adult acute lymphoblastic leukemia (ALL) is a highly heterogeneous hematologic malignancy where treatment response and relapse risk do not exclusively rely on the identification of genetic lesions but also on dynamic biological states sustained by specific transcriptional and epigenetic programs. Although the integrated application of multi-omics approaches has significantly expanded our knowledge of oncogenic dependencies, cellular plasticity, and mechanisms of therapeutic resistance, its systematic translation into the clinical practice of adult ALL is yet to become a reality. The aim of this review is to provide a critical and focused synthesis on how the integration of genomics, transcriptomics, and epigenetics enables the interpretation of disease biological behaviors and may guide personalized therapeutic strategies while simultaneously addressing the major limitations that hinder clinical implementation. Genomics allows for the identification of driver events and pharmacologically actionable vulnerabilities, whereas transcriptomics, including single-cell analyses, reveals functional states associated with clonal persistence, glucocorticoid resistance, and therapeutic adaptation, even in the absence of new mutations. In parallel, epigenetic signatures emerge as key elements in stabilizing oncogenic programs and resistant phenotypes, contributing to the biological plasticity of leukemic cells and representing potentially reversible therapeutic targets. Taken together, multi-omics signatures provide an integrated functional readout of adult ALL and support a dynamic precision-medicine model. However, adaptive therapeutic decisions aimed at relapse prevention require the full integration of these approaches through standardized strategies, longitudinal studies, and a sustainable implementation of molecular profiling and minimal residual disease monitoring. Full article

While Digital Twins offer transformative potential, their efficacy for real-time control is constrained by the slow data acquisition and the high computational intensity required to process raw datasets like point clouds. This paper identifies these critical bottlenecks—specifically the latency between data capture and actionable insight—and proposes a refined theoretical framework for near-real-time automated progress monitoring and quality reporting. Building on the findings of the NORMENG project and informing the subsequent AutoGreenTraC project, this research synthesizes state-of-the-art advancements in reality capture, including LIDAR, SfM-MVS, and 360-degree vision. The study highlights a fundamental divergence in stakeholder requirements: the need for millimeter-level precision in quality control versus the demand for high-velocity documentation for progress monitoring. A key innovation presented is the shift toward neural rendering techniques to bypass the computational delays of traditional photogrammetry and enable immediate on-site visualization. By structuring a tiered processing hierarchy that combines lightweight edge analysis for immediate safety and progress monitoring with asynchronous high-fidelity Digital Twin updates, the framework aims to establish a single source of truth. Full article

Motion sickness (MS), or kinetosis, is a condition experienced by some individuals in response to rhythmic or irregular body motion. Multiple studies have explored its neurobiological mechanisms and countermeasures, with the sensory-conflict hypothesis remaining the most accepted explanation. Heart-rate variability (HRV) and electrocardiography provide complementary autonomic nervous system perspectives that may support MS assessments. From an applied viewpoint, reliable HRV markers could enable the early detection and continuous monitoring of MS in real-world contexts, such as autonomous vehicles, where passenger comfort and safety are critical, motivating contact-free cardiac sensing for unobtrusive monitoring. This systematic review examines the value of HRV indices in MS, conducted under PRISMA guidelines across PubMed, Scopus, and the Web of Science. The included studies were grouped into four categories based on the methods used to induce MS: mechanical stimulus, real trip, visual stimulus, and virtual reality. Aggregated findings indicate that frequency–domain metrics, particularly the low frequency (LF)/high frequency (HF) ratio, HF power, and mean heart rate (mHR), are most frequently reported in relation to MS. Overall, autonomic dysregulation likely contributes to MS susceptibility, but standardized protocols are needed to validate HRV as a reliable marker. Full article

Low-cost air quality sensors enable dense urban monitoring networks but require calibration against reference-grade instruments. While machine learning calibration is well-established for co-located sensor pairs, applying these calibrations to sensors deployed far from any reference station—the operational reality for most network sensors—lacks systematic methodology. We address this gap using 24 months of hourly data (August 2023–July 2025) from Sofia, Bulgaria, where five official reference stations (Executive Environmental Agency) operate alongside 22 AirThings low-cost sensors, four of which are co-located. Random Forest models achieved $R^2\in (0.53,0.75)$ across PM_2.5, PM₁₀, NO₂, and O₃, representing from 40% (for O₃) to 408% (for PM_2.5) improvement over Multiple Linear Regression baselines. Using leave-one-station-out spatial cross-validation, we derived pollutant-specific uncertainty growth rates ($\alpha$) from 3.84% to 5.62% per km, characterizing how calibration uncertainty increases with distance from reference stations (statistically significant for PM₁₀ and O₃, $p<0.05$). Applied to 18 non-co-located sensors, the framework generated 1.2 million calibrated hourly measurements with 95% prediction intervals over the study period. Co-location sites spaced 6 km apart achieve a less than 30% uncertainty increase at network midpoints, within EU Air Quality Directive thresholds for indicative monitoring. These empirically derived $\alpha$ parameters enable network planners to predict measurement reliability at arbitrary sensor locations without ground-truth validation, providing evidence-based guidance for cost-effective hybrid monitoring network design. Full article

Background/Objectives: Dental anxiety represents a significant barrier to oral care in children with neurodevelopmental disorders (NDDs), whose sensory sensitivities and behavioral challenges often complicate clinical management and limit access to treatment. Virtual reality (VR) has emerged as a supportive tool to improve the feasibility of dental procedures in this vulnerable population. This study aims to evaluate whether a VR-based distraction approach could facilitate the completion of dental treatment in children with mild intellectual disability (ID). Methods: A prospective comparative observational study was conducted between February and September 2025 involving 56 children aged 11–15 years with mild ID and moderate dental anxiety (Corah Dental Anxiety Scale, DAS: 9–12). Participants were allocated to two groups of distraction approaches—VR distraction (n = 28) using the Oculus Quest 3^® headset or a monitor-based cartoon (n = 28)—according to device availability and to maintain balanced group sizes. The primary outcome was treatment success, defined as completion of the restorative dental procedure under local anesthesia within 50 min. Results: Treatment success was achieved in 78.6% of the VR group versus 46.4% of the monitor group (p = 0.026). The odds of successful treatment were more than four times higher with VR compared to monitor distraction (OR 4.12; 95% CI: 1.16–16.47), with a risk ratio of 2.50 (95% CI: 1.14–5.50). Stratified analysis suggested a stronger effect in females (OR 12.25; 95% CI: 1.27–118.36) than in males (OR 2.56; 95% CI: 0.53–12.43). Conclusions: VR-based distraction significantly improved dental treatment success in children with mild ID compared with conventional distraction. Although gender differences were observed, they should be interpreted with caution due to the small sample size. This work lays the foundation for developing both short- and long-term protocols to facilitate dental treatment management and cooperation in patients with NDDs. Full article

This paper presents a comprehensive systematic review examining the application of augmented reality (AR) and sensor technologies for visualizing ionizing radiation in virtual training environments. The review methodology involved systematic identification and analysis of the relevant literature based on predetermined criteria including publication type, year of publication, application domain, and technological approach. The literature search encompassed publications from 2011 to 2021 across four major academic databases: Web of Science, Google Scholar, IEEE Xplore, and Scopus. Through rigorous screening following PRISMA 2020 guidelines, 23 research articles met the inclusion criteria for detailed analysis. From 404 initial database records, 360 were excluded during title/abstract screening (primarily for lacking AR components, radiation focus, or training applications) and 4 during full-text assessment (all for lacking sensor integration). The findings reveal that AR-based ionizing radiation visualization has been successfully implemented across diverse domains, including nuclear facility operations, medical procedures, CERN research activities, and educational and monitoring applications. The analysis identified multiple dimensions of impact, encompassing distinct benefits, emerging opportunities, and implementation challenges associated with AR deployment for ionizing radiation training. Each of these dimensions is comprehensively examined and documented within this review. Additionally, this study identifies critical research gaps that currently limit the full potential of AR technology in supporting ionizing radiation training programs. These gaps are systematically analyzed and discussed to establish clear directions for future research endeavors in this emerging field. Full article

There is a growing need for accessible and engaging rehabilitation tools for individuals with neurodevelopmental disorders such as Cerebral palsy (CP), Down syndrome (DS), and Autism spectrum disorder (ASD). Serious games offer a promising approach, yet few are tailor-made to meet the therapeutic demands of these populations. A tailor-made, non-immersive virtual reality (VR) serious games framework featuring a basketball task was developed, with therapist-controlled modules for customization and monitoring. Twenty-eight participants (CP: 14; DS: 7; ASD: 7) completed the game across eight sessions, grouped into three practice phases: an initial session, an early adaptation phase, and a consolidated practice phase. Performance metrics included accuracy, reaction time, and number of victories. All groups improved performance across phases, with accuracy increasing significantly in central (p = 0.005) and total positions (p = 0.007). The number of victories also increased from the initial to the early adaptation phase (p = 0.019) and from the initial to the consolidated practice phase (p = 0.008). Participants with ASD showed significantly higher accuracy than the DS group, while CP and DS participants showed a temporary increase in reaction time during the early adaptation phase, followed by a reduction in the consolidated phase, suggesting task adaptation. These findings support the feasibility and short-term effectiveness of a modular, tailor-made serious games platform for telerehabilitation. Full article

Plug-in hybrid electric vehicles (PHEVs) are expected to reduce fleet CO₂ emissions, but real-world operation often differs markedly from type-approval values. Using European OBFCM data for 457,555 PHEVs (2021–2023) from 14 manufacturers, we quantify the “test-to-reality” CO₂ gap and assess whether traction battery capacity contains an independent signal or mainly reflects vehicle segmentation and in-use behavior. Battery capacity shows only limited standalone explanatory power, while controlling for segment, monitoring year, and manufacturer and incorporating OBFCM-derived usage indicators greatly improves model fit and substantially reduces the apparent battery–gap relationship. We further find strong heterogeneity across vehicle segments, indicating that battery size is not a universal lever of real-world PHEV CO₂ performance. Overall, the results support interpreting battery capacity primarily as a proxy for market positioning and real-world usage (notably charging/engine-dominant operation), highlighting the need to complement type-approval metrics with usage-sensitive indicators when evaluating PHEV compliance in practice. Full article

Power electronic converters are being pushed toward higher power density and switching frequency, turning both design and operation into multi-objective, multi-physics optimization problems. While analytical rules and gradient-based methods remain essential, they often struggle with non-convex, mixed-integer trade-offs that include thermal behavior, Electromagnetic Interference/Electromagnetic Compatibility (EMI/EMC), and reliability constraints. This review surveys intelligent optimization approaches for power electronics across design-time, commissioning-time, and run-time horizons. We propose a deployment-oriented taxonomy of intelligent optimization approaches covering metaheuristics, surrogate-assisted and learning-guided design, constrained optimization via model predictive control, reinforcement learning-based supervisory policies, and hybrid physics-informed methods. For each family, we summarize typical tasks, computational and data requirements, robustness, interpretability, and validation maturity, highlighting where intelligent methods provide clear benefits and where classical approaches remain preferable. Reliability- and diagnostics-oriented optimization is discussed with emphasis on residual-based monitoring, stress-aware operation, and lifetime proxies. Practical adoption barriers—model–reality mismatch, data scarcity, real-time determinism, and certification—are synthesized into recurring design patterns that improve deployability. Finally, a conceptual cognitive design framework is proposed that couples virtual engineering, physics-informed surrogates, human-in-the-loop validation, and knowledge reuse in a closed-loop workflow, offering a structured perspective on how intelligent optimization may be integrated more reliably into industrial design practice. Full article