Search Results (46)

Aortic stenosis is the most prevalent valvular disease globally. Transcatheter aortic valve replacement (TAVR) has become a well-established treatment for aortic stenosis, offering outcomes comparable to surgical aortic valve replacement (SAVR). Its use has expanded to include younger, lower-risk patients and those with more complex anatomies. Recent advancements in TAVR include the increased adoption of transfemoral access, prosthesis designs optimized for challenging anatomies, enhanced delivery systems with repositioning capabilities, and outer skirts to minimize paravalvular leaks. Despite these innovations, several challenges remain. This review highlights recent updates in transcatheter heart valve (THV) systems, leaflet modification devices, and the current limitations of TAVR. Full article

Background/Objective: Changes in limb volume affect prosthetic socket fit and limb health, which in turn affects the comfort, stability, and usability of a prosthesis. The objective of this research was to identify and evaluate residual limb fluid volume metrics that could be used to identify the need for a prosthetic socket modification or replacement. Methods: A prospective observational study was conducted with transtibial prosthesis users undergoing socket modification or replacement. Participants performed a morning and afternoon 20 min structured activity protocol and self-reported their average socket comfort and other health outcomes before and after their socket was modified or replaced. Limb fluid volume changes across the protocol were recorded using bioimpedance analysis. Results: Anterior region residual limb fluid volume loss was low when the socket comfort score was high. Participants with ESCS_ave increases of ≥2 points pre- to post-modification experienced less limb fluid volume loss post-modification minus pre-modification (mean +0.6%) compared to participants with ESCS_ave increases of <2 points (mean −0.9%) (p = 0.0002). Conclusions: The percentage of fluid volume in the anterior limb may be a useful quantitative metric to explore for the application of bioimpedance monitoring in clinical care, helping to identify when sufficient change has occurred such that a new socket is warranted. Full article

Background: Reverse shoulder arthroplasty (RSA) improves shoulder function in cases of glenohumeral osteoarthritis and rotator cuff arthropathy. The design of the glenosphere influences mobility and scapular impingement. This study evaluates the impact of joint volume on the range of motion (RoM) and identifies design modifications to enhance mobility while reducing the impingement risk. Methods: Thirty-four cadaveric shoulders were implanted with the Aequalis Reversed II^® prosthesis in seven configurations: four with 36 mm spheres (centered, 2 mm eccentric, and lateralized by 5 mm and 7 mm) and three with 42 mm spheres (centered, and lateralized by 7 mm and 10 mm). The joint volumes (inferior, anteroinferior, and posteroinferior) were measured via 3D CT scans. The RoM in adduction and elbow-at-side rotations (IR1 and ER1) was recorded. A statistical analysis identified threshold joint volumes correlating with improved mobility. Results: Larger joint volumes correlated with enhanced mobility. The 42 mm spheres demonstrated better adduction and ER1 compared to those of the 36 mm spheres (p < 0.0001). An inferior volume > 5000 mm³ and anteroinferior/posteroinferior volumes >2500 mm³ were thresholds for significant mobility improvement. Lateralization (≥7 mm) or inferior eccentricity (2 mm) improved the mobility with the 36 mm spheres, with the 36 + 2 configuration offering a practical balance for smaller patients. Conclusions: Increased joint volume enhances mobility, particularly in adduction and elbow-at-side rotations. A sphere with a 2 mm inferior offset or a 42 sphere with 7 mm lateralization optimizes the RoM while minimizing impingement risks. Patient-specific considerations, including anatomy and soft tissue tension, remain essential for optimal prosthesis selection. Full article

Traditional myoelectric controls of trans-humeral prostheses fail to provide intuitive coordination of the necessary degrees of freedom. We previously showed that by using artificial neural network predictions to reconstruct distal joints, based on the shoulder posture and movement goals (i.e., position and orientation of the targeted object), participants were able to position and orient an avatar hand to grasp objects with natural arm performances. However, this control involved rapid and unintended prosthesis movements at each modification of the movement goal, impractical for real-life scenarios. Here, we eliminate this abrupt change using novel methods based on an angular trajectory, determined from the speed of stump movement and the gap between the current and the ‘goal’ distal configurations. These new controls are tested offline and online (i.e., involving participants-in-the-loop) and compared to performances obtained with a natural control. Despite a slight increase in movement time, the new controls allowed twelve valid participants and six participants with trans-humeral limb loss to reach objects at various positions and orientations without prior training. Furthermore, no usability or workload degradation was perceived by participants with upper limb disabilities. The good performances achieved highlight the potential acceptability and effectiveness of those controls for our target population. Full article

This study has been carried out to analyze the influence of the design of three geometric elements (wall thickness, platform width, and chamfer) of Ti-base abutments on the distribution of stresses and strains on the implant, the retention screw, the Ti base, and the bone. This study was carried out using FEA, analyzing eight different Ti-base models based on combinations of the geometric factors under study. The model was adapted to the standard Dynamic Loading Test For Endosseous Dental Implants. A force of 360 N with a direction of 30° was simulated and the maximum load values were calculated for each model, which are related to a result higher than the proportional elastic limit of the implant. The transferred stresses according to von Mises and microdeformations were measured for all the alloplastic elements and the simulated support bone, respectively. These results were validated with a static load test using a creep testing machine. The results show that the design factors involved with the most appropriate stress distribution are the chamfer, a thick wall, and a narrow platform. A greater thickness (0.4 mm) is also related to lower stress values according to von Mises at the level of the retaining screws. In general, the distributions of tension at the implants and microdeformation at the level of the cortical and trabecular bone are similar in all study models. The in vitro study on a Ti-base control model determined that the maximum load before the mechanical failure of the implant is 360 N, in accordance with the results obtained for all the Ti-base designs analyzed in the FEA. The results of this FEA study show that modifications to the Ti-base design influence the biomechanical behavior and, ultimately, the way in which tension is transferred to the entire prosthesis–implant–bone system. Full article

Lower limb amputation is a common surgical procedure performed worldwide. Many individuals require amputation due to various circumstances, with amputations occurring above or below the knee. Surgeons rely on published research to determine the most appropriate technique based on intraoperative and postoperative outcomes. The Gritti–Stokes amputation (GSA) procedure, introduced in 1857, has shown positive results in terms of primary wound healing, reduced mortality rates during and after surgery, and accelerated healing and mobility. However, due to the need for highly trained surgeons and limitations in functional and cosmetic prosthesis fitting, concerns have been raised regarding its utility. Additionally, the procedure is underutilized in cases where it could potentially yield better results. This article provides a comprehensive review of the documented benefits of GSA, suitable candidate selection, limitations, various modifications, and a comparison with traditional approaches to lower limb amputation. The review is focused on evidence published in the last 100 years. Full article

For a large benign lesion within the maxillary sinus, such as an antral pseudocyst, maxillary sinus floor augmentation is more commonly performed using a two-stage approach. This involves first removing the lesion, and then, re-entry following several months of healing. In this case series, we described the “one-bony-window” approach, which is a technical surgical modification of the previous one-stage approach, for simultaneous cyst removal and maxillary sinus floor augmentation. Four patients with large maxillary antral pseudocysts were included. The “one-bony-window” approach involves the preparation of a large window opening of approximately 15 mm × 20 mm at the lateral wall. A mesiodistally extended intentional perforation was made in the upper part of the exposed membrane to enhance the access for instrumentation. The antral pseudocyst was removed in its entirety without being deformed to prevent rupture or leakage of the cystic contents. Subsequent detachment and elevation of the Schneiderian membrane at the sinus floor significantly reduced the perforation site, and bone grafting with implant placement was performed simultaneously. This alleviated the need to surgically repair the perforation. The lateral opening was either uncovered or repositioned using bony window lids. Healing abutments were connected after six months, and the final prosthesis was placed after two months. At the 1-year follow-up, the antral pseudocysts had resolved with no specific recurrence, and the stability of the augmented sinus was maintained with excellent implant survival. Within the limitations of our findings, the “one-bony-window” technique can be suggested for the simultaneous removal of large antral pseudocysts and maxillary sinus floor augmentation with favorable clinical outcomes. Full article

This study aims to develop a procedure for the production of 3D-printed forearm prostheses (especially hard outer sockets). The production procedure is designed in the form of a parametric workflow (CAD model), which significantly speeds up the designing process of the prosthesis. This procedure is not fixedly dependent on the software (SW) equipment and is fully transferable into another SW environment. The use of these prostheses will significantly increase the comfort of their patients’ lives. It is possible to produce prostheses faster and in larger amounts and variants by the usage of additive technology. The input for the own production of the prosthesis is a model of the internal soft socket of the patient. This soft socket (soft bed) is made by a qualified prosthetist. A 3D-scanned CAD model is obtained afterward using the scanning method by an automatic laser projector. An editable, parametric external socket (modifiable in any CAD format) is generated from the obtained 3D scan using a special algorithmic model. This socket, after the necessary individual modifications, is transferred to 3D printing technology and produced using powder technology Multi Jet Fusion (HP MJF). The result of the designed and tested procedure is a quickly editable 3D-printed outer socket (main part of prosthesis), which is able to fully replace the current long-fiber composite solution. Production of current solutions is relatively time-consuming, and only one piece is produced in a given time. The newly designed technology eliminates this. This study summarized the possibilities of speeding up the production of forearm prostheses (but not only these) by creating a parametric CAD model that is applicable to different patients. Full article

Objective: Cochlear receptors are sensitive to vibratory stimuli. Based on this sensibility, bone-anchored hearing aids have been introduced to correct unilateral or bilateral conductive or mixed hearing loss and unilateral deafness. The vestibular system is also sensitive to the vibratory stimulus and this type of response is used in clinics to test its functionality. Being aware of this double separated sensibility, we wondered whether bone vibration, which activates the acoustic receptors of patients with bone conduction aids, can also influence the functionality of the vestibular system. Methods: To this end, we recruited 12 patients with a bone-anchored hearing aid and evaluated their vestibular function with and without an activated vibratory acoustic device. Results: Our results show that the vibratory stimulus delivered by the bone conduction aid also reaches and stimulates the vestibular receptors; this stimulation is evidenced by the appearance or modification of some nystagmus findings during bedside vestibular testing. Despite this, none of these patients complained of dizziness or vertigo during prosthesis use. Nystagmus that appeared or changed during acoustic vibratory stimulation through the prosthesis was almost all predominantly horizontal, unidirectional with respect to gaze or body position, inhibited by fixation, and most often consistent with vestibular function tests indicating peripheral vestibular damage. Conclusions: The findings of sound-evoked nystagmus seem to indicate peripheral rather than central vestibular activation. The occurrence of some predominantly horizontal and high-frequency induced nystagmus seems to attribute the response mainly to the utricle and lateral semicircular canal. Full article

The aim of this retrospective case series study was to investigate outcomes in patients with lower limb loss based on whether or not they used a training prosthesis (TP) during rehabilitation. The medical records of 171 consecutive patients admitted to rehabilitation hospitalization between January 2014 and December 2018 following a major amputation of the lower limb were reviewed. Patients were categorized into two groups: patients who underwent rehabilitation with a TP and patients who did not use a TP. Outcomes (i.e., discharge destination, length of stay, number of sockets required, and number of the size adaptation of each socket, as well as functional level) were compared between groups. Of the 171 patients, 126 underwent rehabilitation with a TP, and 45 patients underwent rehabilitation without any TP. In conclusion, we found that patients who used a TP had a significantly shorter hospital length of stay when compared to those who did not. This length of stay for patients with TP was not influenced by age but was lowered by a higher body mass index (BMI), tibial instead of femoral amputation, and the male gender. No association was found between the use of TP and discharge destination, functional level, number of socket modifications, and number of sockets required. Full article

The purpose of this study was to evaluate the inter-limb asymmetry in the kinematic parameters of the approach run in elite-level female Class T63/T64 long jumpers and its relationship to performance. Three Class T63 and nine Class T64 female long jumpers were examined during a competition. The temporal and kinematic parameters of their approach steps (step length: SL; step frequency: SF; average step velocity: SV) were measured using a panning video method and speed radar. The symmetry angle was the measure of inter-limb asymmetry. The results revealed that SF and SV were significantly (p < 0.05) larger in the intact lower limb. Significant (p < 0.05) asymmetry was revealed for SL, SF, and SV in 2/12, 3/12, and 1/12 jumpers, respectively. The direction of asymmetry for SF was towards the leg wearing the prosthesis for all examined jumpers. The official jump distance was significantly (p < 0.05) positively correlated with the maximum velocity attained during the approach and negatively correlated with the symmetry angle for SF. It is concluded that the observed asymmetry in SF was compensated for by the modifications observed in the SL that consequently resulted in no asymmetry in SV, leading the participants to effectively utilize their approach speed optimally in terms of long jump performance. Full article

The removable partial denture, despite new technologies and new materials, continues to play a significant role in clinical dental practice. The purpose of the following study was to evaluate the design of new retention devices in Kennedy class II scenarios. For the study of “lamellar” retentive devices, four prosthetists were chosen. According to inclusion and exclusion criteria, prosthetists selected 16 patients (8 women and 8 men) whose upper arches had to be rehabilitated using a removable partial prosthesis. The results showed that the parameters taken into consideration, such as satisfaction, stability, aesthetics, and retention, had an average score that was higher than 3.30 (range 1–4), with an average standard deviation of 0.6225 in the four parameters, indicative that the data were relatively homogeneous and coherent. In conclusion, we can state that the skeletonized prosthesis with lamellar retentions, designed for Kennedy class II scenarios, has shown high acceptance in selected patients. Full article

The need to modify removable partial dentures equipped with a metal framework in order to add other prosthetic teeth to replace natural teeth lost by the patient could lead to laboratory procedures so complex as to require the creation of new prostheses with a heavy economic burden. The creation of preformed metal pins to be welded using the economical TIG cold welding method could represent a valid alternative solution with the aim of modifying the prostheses using a reinforced resin capable of adequately resisting masticatory loads. This study evaluates and compares the mechanical robustness and the clinical reliability of these modified prostheses in cases of junctions of one or two contiguous prosthetic teeth. The 6-month follow-up demonstrated the total validity of the method via the absence of significant breakages or detachments in all of the patients analyzed; on the other hand, the prostheses modified using the traditional method and used as controls showed a high incidence of fractures. Full article

Even before considering their introduction into the mouth, the choice of materials for the optimization of the prosthesis depends on specific parameters such as their biocompatibility, solidity, resistance, and longevity. In the first part of this two-part review, we approach the various mechanical characteristics that affect this choice, which are closely related to the manufacturing process. Among the materials currently available, it is mainly polymers that are suitable for this use in this field. Historically, the most widely used polymer has been polymethyl methacrylate (PMMA), but more recently, polyamides (nylon) and polyether ether ketone (PEEK) have provided interesting advantages. The incorporation of certain molecules into these polymers will lead to modifications aimed at improving the mechanical properties of the prosthetic bases. In the second part of the review, the safety aspects of prostheses in the oral ecosystem (fragility of the undercuts of soft/hard tissues, neutral pH of saliva, and stability of the microbiota) are addressed. The microbial colonization of the prosthesis, in relation to the composition of the material used and its surface conditions (roughness, hydrophilicity), is of primary importance. Whatever the material and manufacturing process chosen, the coating or finishes dependent on the surface condition remain essential (polishing, non-stick coating) for limiting microbial colonization. The objective of this narrative review is to compile an inventory of the mechanical and physical properties as well as the clinical conditions likely to guide the choice between polymers for the base of removable prostheses. Full article

Periprosthetic joint infections (PJI) are difficult to treat due to biofilm formation on implant surfaces, often requiring removal or exchange of prostheses along with long-lasting antibiotic treatment. This in vitro study investigated the effect of methylene blue photodynamic therapy (MB-PDT) on PJI-causing biofilms on different implant materials. MB-PDT (664 nm LED, 15 J/cm²) was tested on different Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Cutibacterium acnes strains in both planktonic form and grown in early and mature biofilms on prosthetic materials (polyethylene, titanium alloys, cobalt–chrome-based alloys, and bone cement). The minimum bactericidal concentration with 100% killing (MBC_100%) was determined. Chemical and topographical alterations were investigated on the prosthesis surfaces after MB-PDT. Results showed a MBC_100% of 0.5–5 μg/mL for planktonic bacteria and 50–100 μg/mL for bacteria in biofilms—independent of the tested strain, the orthopedic material, or the maturity of the biofilm. Material testing showed no relevant surface modification. MB-PDT effectively eradicated common PJI pathogens on arthroplasty materials without damage to the materials, suggesting that MB-PDT could be used as a novel treatment method, replacing current, more invasive approaches and potentially shortening the antibiotic treatment in PJI. This would improve quality of life and reduce morbidity, mortality, and high health-care costs. Full article