Search Results (645)

The prototypical complex-forming reactions of OH + CO and OH + SO are critical elementary processes in atmospheric chemistry and combustion systems. The vibrational mode-specific quasi-classical trajectory (QCT) investigations for these two reactions were performed on full-dimensional globally accurate potential energy surfaces (PESs). Integral cross-sections (ICS), differential cross-sections (DCS), and product energy distributions for different vibrational excitation modes were calculated and analyzed. Although both exothermic oxygen-transfer reactions share similar topological features in their PES profiles, their energy landscapes exhibit pronounced differences, giving rise to entirely distinct dynamic and kinetic behaviors. This work will advance our understanding of how PES topology, collision energy, and mode-specific vibrational excitation jointly govern reactivity and energy dissipation in radical oxidation processes involving carbon- and sulfur-containing oxides. Full article

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, and internal radionuclide therapy is an important locoregional option for unresectable disease. This review summarizes the current landscape of transarterial radionuclide therapy for HCC and, as a translational perspective, considers how the carrier, radionuclide, and dosimetry concepts established in HCC may extend to secondary liver tumors (liver metastases). It begins with established transarterial radioembolization (TARE/selective internal radiation therapy, SIRT) using yttrium-90 (⁹⁰Y) microspheres and the shift toward personalized dosimetry and combination with systemic and immune-based therapies. It then examines alternative radionuclides and carrier systems—including holmium-166 (¹⁶⁶Ho) microspheres, iodine-131 (¹³¹I) lipiodol, rhenium-188 (¹⁸⁸Re) lipiodol, and lutetium-177 emulsified in lipiodol (¹⁷⁷Lu-lipiodol)—from the standpoint of their physical properties, radiochemistry, theranostic potential, and preclinical and clinical evidence. Particular attention is given to ¹⁷⁷Lu-based approaches, including their favorable beta energy, the concurrent imageable gamma emission that enables single-photon emission computed tomography (SPECT)-based dosimetry, and the potential to address post-embolization hypoxia-related radioresistance, while noting that the clinical evidence for ¹⁷⁷Lu-lipiodol remains preclinical. The application of these platforms to colorectal and neuroendocrine liver metastases is then outlined. Finally, regulatory, radiation safety, and waste management considerations and the principal challenges to clinical translation are discussed. Full article

Urban and peri-urban regions increasingly face climate-related pressures, competing land-use demands, and the need to expand renewable-energy infrastructure while maintaining agricultural land and landscape functions. Agrivoltaics, which combines photovoltaic energy generation with agricultural production, represents a potentially multifunctional approach to land use; however, regional GIS assessments often stop at environmental suitability surfaces without translating those results into planning-relevant cadastral inventories. This study develops and applies a planning-oriented Geographic Information System (GIS) framework for preliminary statewide agrivoltaic screening in Connecticut. Annual global solar radiation and terrain slope were integrated through a weighted suitability model, while incompatible land-cover classes were treated as hard exclusions through a binary land-cover mask. The workflow subsequently excluded protected and open-space lands, associated suitable areas with cadastral parcels, normalized and dissolved parcel identifiers using ParcelKey, and a recalculated suitable area from the resulting unique parcel geometries and then applied a minimum requirement of 1 ha of cumulative suitable area per retained parcel. The final baseline inventory contained 3497 normalized unique cadastral parcels encompassing 16,366.49 ha of GIS-identified suitable area, with suitable land representing an average of 42.46% of total parcel area. Peri-urban contexts accounted for the largest share of the final suitable area, containing 2497 parcels and 73.16% of the total, compared with 476 urban and 524 rural parcels. Sensitivity analysis indicated strong stability under alternative weighting schemes, with spatial overlap exceeding 99% relative to the baseline. Reducing the suitability-score threshold from 3.0 to 2.5 produced only minor changes, whereas increasing it to 3.5 reduced the inventory to 3095 parcels and 13,712.89 ha. From a sustainability perspective, the framework provides a spatial decision-support approach for coordinating renewable-energy planning with agricultural land stewardship, conservation constraints, and more efficient use of already fragmented land resources. By making the effects of exclusions, parcel thresholds, and analytical assumptions explicit, the approach supports more transparent and reproducible evaluation of land-use trade-offs relevant to sustainable development. The resulting inventory is intended as a first-stage planning resource rather than a determination of project feasibility or site-level sustainability performance. Full article

A coordinated extracellular matrix (ECM) and cytoskeletal remodeling are critical drivers of hepatocellular carcinoma (HCC) progression, yet the upstream post-transcriptional mechanisms regulating these processes in spontaneous canine HCC remain poorly defined. Previously, we reported significantly downregulated miRNAs and enriched pathways from differentially expressed genes (DEGs) in canine HCC tissues. In the present study, we investigated putative post-transcriptional target interactions between the prioritized miRNAs and enriched ECM–cytoskeleton pathway-associated genes (n = 34). Integrative bioinformatic analysis prioritized ACTG1 and SDC1 as the key putative targets of cfa-miR-10a based on their concordant prediction by four target-prediction algorithms, high transcript abundance, and inverse correlations with cfa-miR-10a-5p. RNAhybrid and miRanda analyses supported favorable predicted interactions between cfa-miR-10a and the 3′UTRs of both transcripts, with RNAhybrid minimum free energy values ≤ −20 kcal/mol and miRanda scores ≥ 140. In the matched canine transcriptomic subset, cfa-miR-10a and its predicted targets showed inverse expression trends. Cross-species analysis using TCGA-LIHC datasets further demonstrated concordant dysregulation of ACTG1, SDC1 and hsa-miR-10a-5p in human HCC, despite their weak or non-concordant correlation with hsa-miR-10a-5p. Collectively, these exploratory findings identify a candidate cfa-miR-10a–ACTG1/SDC1 network associated with coordinated ECM and cytoskeletal transcriptomic alterations in canine HCC. While cross-species analysis supports the conservation of target gene dysregulation, the divergent miRNA-mRNA correlation patterns highlight potential species-specific post-transcriptional co-expression landscapes that warrant future functional validation. Full article

We investigate reactive collision dynamics and effective interaction cross-sections using classical trajectory simulations on a reduced-dimensional reactive potential-energy surface containing reactant and product wells separated by an intermediate barrier region. The simulations are performed over a range of collision velocities for which direct scattering, transient trapping, and reactive trajectories coexist within the same interaction landscape. Trajectories are propagated using a velocity-Verlet integration scheme, while reaction probabilities are analyzed as functions of the impact parameter and initial projectile velocity. The calculated probability distributions exhibit strongly localized reactive windows in phase space separated by extended nonreactive regions, indicating pronounced sensitivity of the dynamics to both collision geometry and initial conditions. Probability maps in the (v_x,b) plane reveal a fragmented phase-space structure and highly nonuniform accessibility of the interaction region across the investigated parameter range. The simulations further show substantial variations in the relative importance of reactive, trapped, and back-scattering trajectories with increasing collision velocity, together with non-monotonic behavior of the effective reactive cross-sections. Despite the intentionally reduced dimensionality of the model, the trajectory ensembles reproduce several characteristic features of complex reactive scattering dynamics, including transient trapping, competing dynamical pathways, and broad residence-time distributions. The present results demonstrate that reduced-dimensional classical trajectory approaches can already capture important phase-space mechanisms governing dynamical accessibility and channel competition in reactive molecular collisions. Full article

The hydrogen economy has emerged as a promising pathway to address climate change and ensure long-term global energy security, with water electrolysis powered by renewable energy as a key enabler of sustainable hydrogen production. Recent advances in various electrolyser technologies have enhanced their suitability for industrial applications, creating new opportunities for deploying green hydrogen. To address the gap in integrated, multi-dimensional assessment tools for groundwater-based hydrogen systems in water-scarce developing countries, this study develops and presents a Structured Assessment Framework for Green Hydrogen Production from Groundwater in South Africa—the first framework to simultaneously integrate hydrogeological sustainability screening, electrolyser technology selection under groundwater quality constraints, disaggregated levelised cost of hydrogen (LCOH) analysis including water treatment costs, comparative life cycle assessment (LCA) of green, blue, and grey hydrogen pathways, and policy and governance alignment within a single operationalised architecture. This included integrating five thematic dimensions: groundwater resource assessment, electrolyser technology integration, economic viability, environmental sustainability, and policy and governance considerations. This systematic review was conducted in accordance with the PRISMA 2020 guidelines, drawing on 130 studies retrieved from Scopus and Web of Science (2015–2025). The analysis examines groundwater quality and suitability, the technical feasibility of electrolyser systems, and the comparative implications of grey, blue, and green hydrogen pathways on cost and environmental performance. The framework also provides strategic guidance for deploying renewable-energy-powered hydrogen systems, emphasising life-cycle impacts, regulatory alignment, and the potential for decentralised hydrogen hubs. Findings highlight the significance of strengths, weaknesses, opportunities, and threats (SWOT) for green hydrogen production using groundwater in South Africa, including export potential and strong linkages to the circular economy. The study offers actionable insights for policymakers, planners, and industry stakeholders seeking to advance a sustainable and economically competitive hydrogen landscape. Full article

Hashir Hill, also known as Gravity Hill or magnetic hill in Salalah, Oman, is an iconic landmark where vehicles appear to roll uphill on their own. This unusual effect has drawn scientific interest for years. In this study, topographic and gravity measurements were conducted to explore the causes of this phenomenon. Measurements with a Topcon OS-105 compact total station showed that the road actually slopes downward by about 10.5 m over 350 m. Gravity readings from a Scintrex CG-5 gravimeter showed a gradual increase of about 3.17 mGal, which aligns with the free-air gravity correction for the elevation model. No gravity anomalies were found along the route, which suggests the area is in isostatic balance. A physical analysis employing algebraic inequalities related to gravitational potential energy and Newtonian gravity was involved to validate the findings. The results demonstrate that the perceived uphill movement at Hashir Hill is an optical illusion arising from the local landscape’s visual features, rather than from any unusual physical forces. Full article

Assessing the impacts of large-scale photovoltaic plants on soil properties is critical for sustainable land management in arid regions. This study examined a 50 MWp utility-scale PV facility in Siziwangqi, Inner Mongolia, northern China, a cold semi-arid desert steppe where renewable-energy development overlaps with fragile wind-eroded ecosystems. A spatially resolved sampling design contrasted soils at key micro-positions relative to the panels, namely Front, Under, and Behind, with adjacent natural Controls. By integrating laser diffraction analysis, multifractal modeling, and the EPIC erodibility equation, we evaluated soil particle-size probability redistribution and EPIC-estimated intrinsic erodibility. Compared with the silt-dominated surface soil of the natural steppe, soils within the photovoltaic plant exhibited fine-particle retention and lower information and correlation dimensions (D1 and D2), indicating stronger local clustering and a less even particle-size probability distribution. The EPIC-estimated erodibility factor decreased from 0.452 in the Control to approximately 0.361 in the PV micro-locations. These associations should be interpreted as texture- and SOC-based model estimates rather than direct measurements of wind erosion. Overall, multifractal parameters provide complementary proxy descriptors for detecting PV-induced particle sorting and potential changes in intrinsic soil erodibility, underscoring the need for field validation and adaptive management in dryland PV landscapes. These findings provide physical soil evidence for evaluating the environmental sustainability of dryland PV development and for supporting adaptive land management in solar farms. Full article

MXene composites represent an exceptionally promising member of the family of two-dimensional multifunctional materials known for outstanding electrical properties, mechanical strength, chemical tuning abilities, and the potential for wide applications. The paper conducts a profound patent landscape investigation of MXene composites with the help of the WIPO PATENTSCOPE database. In total, 658 patent families were found; duplicate patent entries were eliminated through the application of the Single Family Member method. The results show that China is a patent leader worldwide, followed by PCT applications and the patenting activity of the USA, India, and other countries, which indicates a growing international interest in MXene technologies and materials. The classification of patents also shows that this technology is actively researched in relation to the development of technologies in the field of electrochemical energy storage, polymer engineering, sensing technologies, catalysis, environmental remediation, electronics, and biomedical applications. Additionally, the paper studies the technology development in the field of the creation of MXene antennas, semiconductor devices, and ceramic oxide composites, materials that change shape, anti-corrosion coatings, electrochemical sensors, and many others. Even though substantial advances have been made, obstacles related to efficient manufacturing, oxidation resistance, quality assurance, sustainability, and industry adoption persist. The overall picture of patents shows that MXene-based composite materials have progressed from the testing stage to commercial products with high potential for next-generation technologies. Full article

Vairimorpha ceranae, an obligate intracellular parasitic fungus, infects the midgut of worker Apis cerana cerana, disrupts nutritional metabolism and immune homeostasis of hosts, and poses severe threats to honeybee health and the sustainable development of apiculture. To date, the expression dynamics of circular RNAs (circRNAs) during pathogen infection and their regulatory functions as competing endogenous RNAs (ceRNAs) remain poorly characterized. In this study, circRNA sequencing was performed on purified V. ceranae spores (VcCK), as well as the midguts of A. cerana cerana worker bees at 7 days post-infection (VcT1) and 10 days post-infection (VcT2). A total of 8,986,470 and 315 circRNAs were identified from the three groups, with their lengths predominantly ranging from 200 to 600 nt. Differential expression analysis screened 575 and 594 differentially expressed circRNAs (DEcircRNAs) from the VcCK vs. VcT1 and VcCK vs. VcT2 comparison groups, respectively. The host genes generating these DEcircRNAs were annotated to 316 and 310 GO terms, alongside 167 KEGG pathways. CeRNA network analysis revealed that DEcircRNAs including novel_circ_006653 target multiple miRNAs, and their downstream target mRNAs are significantly enriched in energy metabolism pathways such as carbon metabolism and glycolysis/gluconeogenesis. RT-qPCR validation exhibited high consistency with transcriptome sequencing data. Further analyses demonstrated that V. ceranae infection drastically remodels the circRNA expression landscape: the total number of circRNAs was sharply reduced, and the dominant circRNA subtype shifted from antisense circRNAs to single-exon circRNAs. Several DEcircRNAs (novel_circ_006653, novel_circ_004839, novel_circ_005596, etc.) may participate in pathogen infection progression via the ceRNA regulatory axis by modulating host energy metabolism, immune responses and cellular biological processes. This study provides novel insights into the molecular interaction mechanisms between microsporidian parasites and their honeybee hosts, and identifies potential molecular targets for the prevention and control of microsporidiosis. Full article

The Qinghai–Tibet Plateau, with an elevation of 4000 m above sea level, is rich in biological resources, and all the native creatures are exposed to extremely inhospitable environmental challenges. However, the detailed adaptation mechanisms of the native organisms to such an environment are still unclear. In this study, in-depth high-throughput RNA-Seq sequencing and metabolome data were deployed to depict the transcription and metabolism landscape of pikas living at 4630 and 2600 m altitude to elucidate the multilayer adaptation mechanisms of pikas to the environment of the Qinghai–Tibet Plateau. We identified significant variations in transcription and metabolism between pikas from 4630 and 2600 m. Various genes functioned in inflammatory-related pathways, including inflammatory mediator regulation of TRP channels and GnRH/HIF-1/p53/TNF signaling pathways, which were more active in pikas from 4630 m. Immune-response-related genes were overall downregulated in high-altitude pikas (e.g., genes for pro-inflammatory mediator synthesis and immune cell recruitment); this may represent a potential adaptive immunomodulatory mode in response to hypoxic stress. The expression of genes involved in cardiac muscle contraction and oxidative phosphorylation pathways was lower in pikas from 4630 m, leading to advantages for pikas in obtaining sufficient oxygen. Pikas from 4630 m have a more active metabolism relevant to amino acids and lipids, which provides energy for pikas to adapt to a high-altitude environment. Metabolome results reach a consensus with metabolic analysis from the transcriptome that pikas from 4630 m contain high levels of various amino acids and lipids. Overall, our study reveals multi-layer adaptive signatures in the left ventricle of plateau pikas at both transcriptional and metabolic levels, advancing our understanding of how Ochotona curzoniae adapts to high-altitude hypoxia on the Qinghai–Xizang Plateau. Full article

Rapid urban-industrial development has intensified surface warming in global cities, including India, posing critical challenges for sustainable urban environments. While advanced AI and remote sensing methods have mapped urban heat patterns, a fundamental thermodynamic understanding of how cities generate, absorb, store, and dissipate heat with the urban land transformation remains underexplored. This study conceptualizes the urban geo-thermodynamics mechanism as a comprehensive framework to quantify urban surface energy exchanges, heat flux dynamics, and thermal responses in the Haldia urban-industrial region (103.84 km²) of eastern India. The analysis employs Landsat-derived impervious surface expansion, land surface temperature (LST), and normalized difference vegetation index (NDVI), NASA POWER radiation fluxes, world settlement footprint 3D structural (2023) and material stock (2024) data, and census-based population records (1991–2021). The integrated mathematical formulations were developed after the remote sensing-GIS-based statistical analysis for the urban energy balance through the Urban Thermodynamic Index (UTI), Urban Heat Retention Efficiency (UHRE), and Urban Cooling Potential (UCP) indices, which were developed from energy balance equations linking net radiation (Q*), anthropogenic flux (${\mathrm{Q}}_{\mathrm{F}}$), sensible and ground heat (${\mathrm{Q}}_{\mathrm{H}}$, ${\mathrm{Q}}_{\mathrm{G}}$), and latent heat flux (${\mathrm{Q}}_{\mathrm{E}}$). The results reveal a 36% increase in UTI and a 28% rise in UHRE between 1991 and 2021, indicating enhanced surface heat accumulation and anthropogenic energy input associated with built-up area and population growth (22.87–53.37 km²) and (1452–2375 person/km²). In contrast, UCP declined by 22%, reflecting reduced evaporative cooling due to vegetation loss, with the regression-based calibration (R² = 0.89; RMSE = 0.74 °C) validating strong correspondence with observed LST. These findings demonstrate a quantifiable link between thermodynamic processes and the transformation of the urban morphological landscape. The proposed mathematical-thermodynamic structure provides a scientific, GIS-based statistical method for urban heat risk assessment, energy-efficient planning, and geo-thermal environmental management, supporting global initiatives toward climate-resilient and sustainable urban development. Full article

Urban forests play a crucial role in sustaining habitable urban environments, and tree canopy height (TCH) is a key parameter for characterizing urban forest structure and ecological functions. However, accurate TCH retrieval using spaceborne lidar remains challenging in urban built-up areas because of the high spatial heterogeneity of urban land cover. This study proposes an urban-oriented method for ICESat-2 data processing and TCH extraction and evaluates it in Peoria, Illinois, USA. By integrating spectral constraints with photon spatial distribution patterns, the method further separates non-ground photons into vegetation photons and building photons. Individual tree crown polygons are then introduced as spatial constraints for TCH extraction, helping to overcome the limitations of regular grids in representing both the laser footprint scale and fine urban landscape detail. In addition, a non-exclusive photon-to-crown assignment strategy based on energy weighting allowed each photon to contribute to multiple crowns in proportion to the footprint energy intercepted by each crown. Among the 1391 crowns associated with vegetation photons, 286 met the thresholds for both total and high-weight photon counts and were retained for accuracy assessment. Validation against canopy heights derived from airborne laser scanning (ALS) reference data shows that the proposed method achieves an R² of 0.55 and an RMSE of 2.71 m. Further analysis indicates that retrieval accuracy is primarily controlled by beam strength: strong beams yield higher accuracy (R² ≈ 0.60), whereas daytime and nighttime observations differ only slightly. Overall, after targeted processing, ICESat-2 can provide a set of individual tree canopy height samples in urban built-up areas, which may support local calibration and serve as potential labels for subsequent regional canopy height mapping. Full article

Assessing run-of-river small hydropower (SHP) potential requires balancing conflicting technical, economic, and socio-environmental criteria. Traditional assessment frameworks rely on discrete point-based site inventories, which often overlook regional landscape constraints and project overlap. To overcome this limitation, this study introduces the concept of a Feasibility Surface ($FS$), a novel, continuous spatial landscape that maps overall development viability across an entire drainage basin. Operating within a Geographic Information System ($GIS$), we integrated the Analytic Hierarchy Process ($AHP$) to systematically weight nine multi-dimensional variables across Economic, Ecological, and Social criteria. Input layers were max-normalized using criterion-specific rules and aggregated through a weighted linear combination to generate a continuous Feasibility Index ($FI$). Applied to the Huazuntlán River basin in Mexico, the resulting continuous surface successfully delineates optimal development corridors, moving beyond fixed-point targets. Local one-at-a-time sensitivity analyses confirmed that these spatial clusters are physically robust and highly stable under weight variations. Furthermore, an exhaustive combinatorial search was executed over the continuous surface to extract optimal, non-overlapping multi-plant portfolios that avoid hydraulic interference. Mathematically and practically, this continuous feasibility landscape provides a valuable macro-screening tool for sustainable water resource planning. It allows environmental managers and energy developers to prioritize alternative exploitation corridors, balance localized ecological constraints, and optimize distributed renewable energy portfolios without compromising basin-scale ecological integrity. Full article

The paper explores the underutilized potential of geothermal energy in Romania, focusing on both shallow and deep geothermal systems as sustainable alternatives for heating applications. Romania’s unique geological features, particularly the Pannonian Depression, offer significant geothermal resources, yet these remain largely untapped in many regions. This study presents an analysis of the country’s geothermal reservoirs, highlighting their spatial distribution, thermophysical properties, and technical potential. In-depth data on aquifer characteristics, including temperatures, depths, and capacities, supports a comprehensive assessment of the energy output achievable from these natural systems. Current applications of geothermal resources are reviewed, including successful projects in Oradea and Timiș County, which demonstrate the viability of geothermal systems for residential and commercial heating. Furthermore, this study discusses Romania’s regulatory landscape and incentive frameworks aligned with European Union standards, identifying key barriers and opportunities for growth. With a robust foundation of technical and spatial data, this paper underscores the strategic role geothermal energy can play in Romania’s transition to a low-carbon economy, supporting both environmental sustainability and energy resilience. The results demonstrate how geomatics-based resource mapping and spatial analysis support evidence-based planning of geothermal energy systems at regional and national scales. Full article