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  • Article
  • Open Access
1 Citations
2,365 Views
16 Pages

First National Prevalence in Italian Horse Population and Phylogenesis Highlight a Fourth Sub-Type Candidate of Equine Hepacivirus

  • Roberto Nardini,
  • Giulia Pacchiarotti,
  • Valentina Svicher,
  • Romina Salpini,
  • Maria Concetta Bellocchi,
  • Raffaella Conti,
  • Marcello Giovanni Sala,
  • Davide La Rocca,
  • Luca Carioti and
  • Maria Teresa Scicluna
  • + 3 authors

16 April 2024

Equine hepacivirus (EqHV, Flaviviridae, hepacivirus) is a small, enveloped RNA virus generally causing sub-clinical hepatitis with occasional fatalities. EqHV is reported in equids worldwide, but for Italy data are limited. To address this, a survey...

  • Article
  • Open Access
8 Citations
3,875 Views
12 Pages

Phylogenesis of the Functional 1-Aminocyclopropane-1-Carboxylate Oxidase of Fungi and Plants

  • Yanan Li,
  • Man Qi,
  • Qi Zhang,
  • Zhixu Xu,
  • Yan Zhang,
  • Yuqian Gao,
  • Yuancheng Qi,
  • Liyou Qiu and
  • Mingdao Wang

29 December 2022

The 1-aminocyclopropane-1-carboxylic acid (ACC) pathway that synthesizes ethylene is shared in seed plants, fungi and probably other organisms. However, the evolutionary relationship of the key enzyme ACC oxidase (ACO) in the pathway among organisms...

  • Systematic Review
  • Open Access
1 Citations
2,809 Views
25 Pages

Molecular Characterization of Small Ruminant Lentiviruses in Sheep and Goats: A Systematic Review

  • Paola Gobbi,
  • Silvia Pavone,
  • Massimiliano Orso,
  • Fabrizio Passamonti,
  • Cecilia Righi,
  • Maria Serena Beato,
  • Francesco Feliziani and
  • Monica Giammarioli

8 December 2024

Small ruminant lentiviruses (SRLVs) are responsible for chronic and progressive multisystemic clinical forms, which significantly reduce flocks’ productivity and have a considerable economic impact on the small ruminant industry. Due to the inc...

  • Review
  • Open Access
68 Citations
9,750 Views
13 Pages

Monkeypox, a Literature Review: What Is New and Where Does This concerning Virus Come From?

  • Giorgio Tiecco,
  • Melania Degli Antoni,
  • Samuele Storti,
  • Lina Rachele Tomasoni,
  • Francesco Castelli and
  • Eugenia Quiros-Roldan

27 August 2022

Among the Poxviridae family, orthopoxvirus is the most notorious genus. Several DNA viruses belonging to this group are known to produce human disease from the life-threatening variola virus (VARV) (the causative agent of smallpox), monkeypox virus (...

  • Communication
  • Open Access
3 Citations
2,659 Views
15 Pages

6 August 2023

Nuclear and cytoplasmic DNA barcoding regions are useful for plant identification, breeding, and phylogenesis. In this study, the genetic diversity of 17 Diplotaxis species, was investigated with 5 barcode markers. The allelic variation was based on...

  • Article
  • Open Access
33 Citations
3,657 Views
12 Pages

Genetic Characterization of Porcine Circovirus 3 Strains Circulating in Sardinian Pigs and Wild Boars

  • Silvia Dei Giudici,
  • Giulia Franzoni,
  • Piero Bonelli,
  • Pier Paolo Angioi,
  • Susanna Zinellu,
  • Viviana Deriu,
  • Tania Carta,
  • Anna Maria Sechi,
  • Francesco Salis and
  • Annalisa Oggiano
  • + 1 author

Porcine circovirus 3 (PCV3) is a recently discovered member of the Circoviridae family. So far, its presence has been reported in North America, Asia, South America, and Europe. In this study, blood and tissue samples from 189 Sardinian suids (34 dom...

  • Article
  • Open Access
21 Citations
3,938 Views
14 Pages

Ecotyping of Anaplasma phagocytophilum from Wild Ungulates and Ticks Shows Circulation of Zoonotic Strains in Northeastern Italy

  • Laura Grassi,
  • Giovanni Franzo,
  • Marco Martini,
  • Alessandra Mondin,
  • Rudi Cassini,
  • Michele Drigo,
  • Daniela Pasotto,
  • Elena Vidorin and
  • Maria Luisa Menandro

26 January 2021

Anaplasma phagocytophilum (A. phagocytophilum) is a tick-borne pathogen causing disease in both humans and animals. Human granulocytic anaplasmosis (HGA) is an emerging disease, but despite the remarkable prevalence in European ticks and wild animals...

  • Review
  • Open Access
9 Citations
5,381 Views
13 Pages

B Chromosomes in Genus Sorghum (Poaceae)

  • Martina Bednářová,
  • Miroslava Karafiátová,
  • Eva Hřibová and
  • Jan Bartoš

9 March 2021

B chromosomes (Bs) are supernumerary dispensable genomic elements that have been reported in several thousand eukaryotic species. Since their discovery, Bs have been subjected to countless studies aiming at the clarification of their origin, composit...

  • Article
  • Open Access
5 Citations
3,105 Views
20 Pages

Distinct Uptake Routes Participate in Silver Nanoparticle Engulfment by Earthworm and Human Immune Cells

  • Bohdana Kokhanyuk,
  • Viola Bagóné Vántus,
  • Balázs Radnai,
  • Eszter Vámos,
  • Gyula Kajner,
  • Gábor Galbács,
  • Elek Telek,
  • Mária Mészáros,
  • Mária A. Deli and
  • Péter Engelmann
  • + 1 author

17 August 2022

The consequences of engineered silver nanoparticle (AgNP) exposure and cellular interaction with the immune system are poorly understood. The immunocytes of the Eisenia andrei earthworm are frequently applied in ecotoxicological studies and possess f...

  • Article
  • Open Access
14 Citations
2,726 Views
13 Pages

The identification and classification of strains of Acanthamoeba, a potentially pathogenic ubiquitous free-living amoeba, are largely based on the analysis of 18S rDNA sequences, currently delineating 23 genotypes, T1 to T23. In this study, the seque...

  • Article
  • Open Access
15 Citations
4,099 Views
14 Pages

Occurrence of Macrophomina phaseolina on Chickpea in Italy: Pathogen Identification and Characterization

  • Eliana Dell’Olmo,
  • Pasquale Tripodi,
  • Massimo Zaccardelli and
  • Loredana Sigillo

Climate change has led to the spread of plant pathogens in novel environments, causing dramatic crop losses and economic damage. Botryosphaeriaceae represents a massive fungal family, containing a huge number of plant pathogens, which are able to inf...

  • Systematic Review
  • Open Access
10 Citations
4,240 Views
29 Pages

20 September 2022

Viral hepatitis has recently assumed relevance for equine veterinary medicine since a variety of new viruses have been discovered. Equine Hepacivirus (EqHV) is an RNA virus belonging to the Flaviviridae family that can cause subclinical hepatitis in...

  • Article
  • Open Access
17 Citations
2,696 Views
13 Pages

Acanthamoeba is a ubiquitous free-living amoeba capable of being an opportunistic pathogen in humans and animals. A critical step in infection is the adhesion of the amoeba to host cells and tissues, and two major parasite adhesins, mannose-binding p...

  • Article
  • Open Access
17 Citations
5,361 Views
12 Pages

Immunohistochemistry of the Gut-Associated Lymphoid Tissue (GALT) in African Bonytongue (Heterotis niloticus, Cuvier 1829)

  • Eugenia Rita Lauriano,
  • Alessio Alesci,
  • Marialuisa Aragona,
  • Simona Pergolizzi,
  • Anthea Miller,
  • Kristina Zuwala,
  • Michal Kuciel,
  • Giacomo Zaccone,
  • Antonino Germanà and
  • Maria Cristina Guerrera

24 January 2023

Heterotis niloticus is a basal teleost, belonging to the Osteoglossidae family, which is widespread in many parts of Africa. The digestive tract of H. niloticus presents similar characteristics to those of higher vertebrates, exhibiting a gizzard-lik...

  • Article
  • Open Access
2 Citations
2,014 Views
15 Pages

Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals

  • Barshagul Baikara,
  • Kobey Karamendin,
  • Yermukhammet Kassymbekov,
  • Klara Daulbayeva,
  • Temirlan Sabyrzhan,
  • Sardor Nuralibekov,
  • Yelizaveta Khan,
  • Nurlan Sandybayev,
  • Sasan Fereidouni and
  • Aidyn Kydyrmanov

8 May 2025

Low pathogenic H9N2 avian influenza viruses have become widespread in wild birds and poultry worldwide, raising concerns about their potential to spark pandemics or their role in enhancing the virulence and infectivity of H5Nx viruses through genetic...

  • Article
  • Open Access
2 Citations
1,406 Views
17 Pages

Genome Sequencing of a Fusarium Endophytic Isolate from Hazelnut: Phylogenetic and Metabolomic Implications

  • Andrea Becchimanzi,
  • Beata Zimowska,
  • Marina Maura Calandrelli,
  • Luigi De Masi and
  • Rosario Nicoletti

This study reports on the whole genome sequencing of the hazelnut endophytic Fusarium isolate Hzn5 from Poland. It was identified as a member of the Fusarium citricola species complex based on a phylogenetic analysis which also pointed out that other...

  • Article
  • Open Access
2 Citations
1,386 Views
9 Pages

3 February 2025

Blastocystis is a common intestinal protist with a global distribution, frequently found in humans and various animals. Despite its prevalence, its role in human health remains debated, oscillating between being a harmless commensal and a potential p...

  • Article
  • Open Access
7 Citations
2,586 Views
15 Pages

Genetic Characterization of Echinococcus granulosus sensu stricto Isolated from Human Cysts from Sardinia, Italy

  • Cinzia Santucciu,
  • Piero Bonelli,
  • Angela Peruzzu,
  • Alessandro Fancellu,
  • Antonella Farà,
  • Scilla Mastrandrea,
  • Giovanni Drocchi,
  • Antonio Cossu,
  • Stefano Profili and
  • Giovanna Masala
  • + 1 author

This study involved 20 patients affected by cystic echinococcosis (CE) who were referred to different hospitals of Sardinia (Italy) from 2017 to 2022. By means of a multidisciplinary approach, diagnosis was confirmed for CE in 18 patients and for dif...

  • Review
  • Open Access
312 Citations
26,945 Views
49 Pages

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

  • Giorgio Milazzo,
  • Daniele Mercatelli,
  • Giulia Di Muzio,
  • Luca Triboli,
  • Piergiuseppe De Rosa,
  • Giovanni Perini and
  • Federico M. Giorgi

15 May 2020

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide...

  • Article
  • Open Access
2 Citations
4,333 Views
10 Pages

Phylogenetic Relationships between Phlebiopsis gigantea and Selected Basidiomycota Species Inferred from Partial DNA Sequence of Elongation Factor 1-Alpha Gene

  • Marcin Wit,
  • Zbigniew Sierota,
  • Anna Żółciak,
  • Ewa Mirzwa-Mróz,
  • Emilia Jabłońska and
  • Wojciech Wakuliński

24 May 2020

Phlebiopsis gigantea (Fr.) Jülich has been successfully used as a biological control fungus for Heterobasidion annosum (Fr.) Bref., an important pathogen of pine and spruce trees. The P. gigantea species has been known for many years, but our un...

  • Article
  • Open Access
3 Citations
2,074 Views
13 Pages

Conflicting Evidence between Clinical Perception and Molecular Epidemiology: The Case of Fowl Adenovirus D

  • Giovanni Franzo,
  • Giulia Faustini,
  • Claudia Maria Tucciarone,
  • Daniela Pasotto,
  • Matteo Legnardi and
  • Mattia Cecchinato

14 December 2023

Fowl adenoviruses (FAdVs, species FAdV-A/-E) are responsible for several clinical syndromes reported with increasing frequency in poultry farms in the last decades. In the present study, a phylodynamic analysis was performed on a group of FAdV-D Hexo...

  • Article
  • Open Access
15 Citations
5,024 Views
19 Pages

Algerian Olive Germplasm and Its Relationships with the Central-Western Mediterranean Varieties Contributes to Clarify Cultivated Olive Diversification

  • Kamel Atrouz,
  • Ratiba Bousba,
  • Francesco Paolo Marra,
  • Annalisa Marchese,
  • Francesca Luisa Conforti,
  • Benedetta Perrone,
  • Hamza Harkat,
  • Amelia Salimonti and
  • Samanta Zelasco

1 April 2021

Olive tree with its main final product, olive oil, is an important element of Mediterranean history, considered the emblematic fruit of a civilization. Despite its wide diffusion and economic and cultural importance, its evolutionary and phylogenetic...

  • Case Report
  • Open Access
3 Citations
2,265 Views
8 Pages

First Case of Candida Auris Sepsis in Southern Italy: Antifungal Susceptibility and Genomic Characterisation of a Difficult-to-Treat Emerging Yeast

  • Stefania Stolfa,
  • Giuseppina Caggiano,
  • Luigi Ronga,
  • Lidia Dalfino,
  • Francesca Centrone,
  • Anna Sallustio,
  • Davide Sacco,
  • Adriana Mosca,
  • Monica Stufano and
  • Maria Chironna
  • + 9 authors

Candida auris is an emerging yeast considered a serious threat to global health. We report the first case of C. auris candidemia in Southern Italy, characterized using whole genome sequencing (WGS), and compared with a second strain isolated from a p...

  • Article
  • Open Access
2 Citations
1,333 Views
11 Pages

The molecular classification of Acanthamoeba is currently based on the analysis of 18S rDNA sequences, delimiting around twenty genotypes (T1–T23). In some cases, however, the resolution of 18S is limited, and other genetic markers could be use...

  • Communication
  • Open Access
3 Citations
2,059 Views
7 Pages

Phylogenetic Analysis of Chandipura virus: Insights from a Preliminary Genomic Study

  • Marta Giovanetti,
  • Valeria Micheli,
  • Alessandro Mancon,
  • Davide Mileto and
  • Alberto Rizzo

25 January 2025

Chandipura virus (CHPV) is an arthropod-borne virus linked to encephalitis in humans, primarily in India. Its evolutionary dynamics and transmission pathways remain poorly understood due to limited genomic data. This study analyzed 23 publicly availa...

  • Article
  • Open Access
2 Citations
1,604 Views
12 Pages

Molecular Genotyping of Circulating Enterovirus in the Lazio Region from 2012 to 2023

  • Martina Rueca,
  • Francesco Vairo,
  • Martina Spaziante,
  • Lavinia Fabeni,
  • Federica Forbici,
  • Giulia Berno,
  • Cesare Ernesto Maria Gruber,
  • Simonetta Picone,
  • Camilla Ajassa and
  • Maria Beatrice Valli
  • + 2 authors

24 June 2024

Enteroviruses (EVs) are ubiquitous viruses that circulate worldwide, causing sporadic or epidemic infections, typically during the summer and fall. They cause a broad spectrum of illnesses, ranging from an unspecified febrile clinical presentation to...

  • Article
  • Open Access
4 Citations
2,633 Views
10 Pages

Detection and Molecular Characterization of a Novel Species of Circovirus in a Tawny Owl (Strix aluco) in Southern Italy

  • Matteo Legnardi,
  • Laura Grassi,
  • Giovanni Franzo,
  • Maria Luisa Menandro,
  • Claudia Maria Tucciarone,
  • Adriano Minichino,
  • Ludovico Dipineto,
  • Luca Borrelli,
  • Alessandro Fioretti and
  • Mattia Cecchinato

7 January 2022

Thanks to recent developments in molecular methods, many new species have been discovered within the genus Circovirus, which comprises viruses of veterinary relevance found in a broad range of hosts. In particular, several circoviruses are known to i...

  • Article
  • Open Access
14 Citations
3,583 Views
17 Pages

Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket

  • Anna Bertelli,
  • Pasqualina D’Ursi,
  • Giovanni Campisi,
  • Serena Messali,
  • Maria Milanesi,
  • Marta Giovanetti,
  • Massimo Ciccozzi,
  • Francesca Caccuri and
  • Arnaldo Caruso

14 December 2021

Genotype screening was implemented in Italy and showed a significant prevalence of new SARS-CoV-2 mutants carrying Q675H mutation, near the furin cleavage site of spike protein. Currently, this mutation, which is expressed on different SARS-CoV-2 lin...

  • Article
  • Open Access
14 Citations
3,496 Views
12 Pages

Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?

  • Giovanni Franzo,
  • Maria Luisa Menandro,
  • Claudia Maria Tucciarone,
  • Giacomo Barbierato,
  • Lorenzo Crovato,
  • Alessandra Mondin,
  • Martina Libanora,
  • Federica Obber,
  • Riccardo Orusa and
  • Laura Grassi
  • + 2 authors

9 August 2021

Canine circovirus (CanineCV) is a recently identified virus affecting both domestic and wild carnivores, including foxes, sometimes in presence of severe clinical signs. Its circulation in wild animals can thus represent a potential threat for endang...

  • Article
  • Open Access
5 Citations
3,238 Views
17 Pages

29 September 2022

The biogenetic law (recapitulation law) states that ontogenesis recapitulates phylogenesis. However, this law can be distorted by the modification of development. We showed the recapitulation of phylogenesis during the differentiation of various cell...

  • Feature Paper
  • Article
  • Open Access
22 Citations
5,029 Views
28 Pages

10 October 2020

Calcium (Ca2+) plays a critical role in the regulation of growth and development and environmental stress responses in plants. The membrane-associated Ca2+ transport proteins are required to mediate Ca2+ signaling and maintain Ca2+ homeostasis. Ca2+...

  • Review
  • Open Access
17 Citations
6,930 Views
16 Pages

Fruit Breeding in Regard to Color and Seed Hardness: A Genomic View from Pomegranate

  • Xinhui Zhang,
  • Yujie Zhao,
  • Yuan Ren,
  • Yuying Wang and
  • Zhaohe Yuan

10 July 2020

Many fruit trees have been whole-genome sequenced, and these genomic resources provide us with valuable resources of genes related to interesting fruit traits (e.g., fruit color, size and taste) and help to facilitate the breeding progress. Pomegrana...

  • Review
  • Open Access
62 Citations
11,304 Views
40 Pages

15 June 2015

The genus Sobemovirus, unassigned to any family, consists of viruses with single-stranded plus-oriented single-component RNA genomes and small icosahedral particles. Currently, 14 species within the genus have been recognized by the International Com...

  • Review
  • Open Access
28 Citations
14,262 Views
37 Pages

8 July 2010

In the last two decades, large scale axenic cell cultures of the marine species comprising the family Euplotidae have resulted in the isolation of several new classes of terpenoids with unprecedented carbon skeletons including the (i) euplotins, high...

  • Article
  • Open Access
13 Citations
5,200 Views
19 Pages

Genome Mining of Non-Conventional Yeasts: Search and Analysis of MAL Clusters and Proteins

  • Katrin Viigand,
  • Kristina Põšnograjeva,
  • Triinu Visnapuu and
  • Tiina Alamäe

16 July 2018

Genomic clustering of functionally related genes is rare in yeasts and other eukaryotes with only few examples available. Here, we summarize our data on a nontelomeric MAL cluster of a non-conventional methylotrophic yeast Ogataea (Hansenula) polymor...

  • Article
  • Open Access
3 Citations
3,733 Views
9 Pages

Genome and Phylogenetic Analysis of Infectious Hematopoietic Necrosis Virus Strain SNU1 Isolated in Korea

  • Woo Taek Oh,
  • Jin Woo Jun,
  • Sib Sankar Giri,
  • Saekil Yun,
  • Hyoun Joong Kim,
  • Sang Guen Kim,
  • Sang Wha Kim,
  • Se Jin Han,
  • Jun Kwon and
  • Se Chang Park

21 October 2019

Infectious hematopoietic necrosis virus (IHNV), one of the most important pathogenic fish viruses, affects trout fisheries and causes considerable economic losses. Currently, in Korea, more studies on IHNV infection are being reported. However, relat...

  • Article
  • Open Access
3 Citations
6,443 Views
26 Pages

A Data-Driven Approach to Construct a Molecular Map of Trypanosoma cruzi to Identify Drugs and Vaccine Targets

  • Swarsat Kaushik Nath,
  • Preeti Pankajakshan,
  • Trapti Sharma,
  • Priya Kumari,
  • Sweety Shinde,
  • Nikita Garg,
  • Kartavya Mathur,
  • Nevidita Arambam,
  • Divyank Harjani and
  • Kamal Rawal
  • + 11 authors

26 January 2023

Chagas disease (CD) is endemic in large parts of Central and South America, as well as in Texas and the southern regions of the United States. Successful parasites, such as the causative agent of CD, Trypanosoma cruzi have adapted to specific hosts d...

  • Article
  • Open Access
43 Citations
5,728 Views
12 Pages

Compartmentalized Replication of SARS-Cov-2 in Upper vs. Lower Respiratory Tract Assessed by Whole Genome Quasispecies Analysis

  • Martina Rueca,
  • Barbara Bartolini,
  • Cesare Ernesto Maria Gruber,
  • Antonio Piralla,
  • Fausto Baldanti,
  • Emanuela Giombini,
  • Francesco Messina,
  • Luisa Marchioni,
  • Giuseppe Ippolito and
  • Maria Rosaria Capobianchi
  • + 1 author

We report whole-genome and intra-host variability of SARS-Cov-2 assessed by next generation sequencing (NGS) in upper (URT) and lower respiratory tract (LRT) from COVID-19 patients. The aim was to identify possible tissue-specific patterns and signat...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,789 Views
13 Pages

Multiple Typing Approach to Characterize Toxoplasma gondii Strains from Captive and Livestock Species in Northern Italy Suggests the Circulation of Type-II Variants

  • Filippo Maria Dini,
  • Martha Ynés Salas-Fajardo,
  • Roberta Taddei,
  • Mattia Ramini,
  • Silvia Vianello,
  • Monica Caffara and
  • Roberta Galuppi

12 December 2024

Toxoplasma gondii is a widespread foodborne parasite that affects both humans and animals worldwide. The genetic characterization of this parasite has become crucial due to its epidemiological and clinical implications. The present study focused on t...

  • Article
  • Open Access
2 Citations
2,100 Views
13 Pages

In Silico Predicting the Presence of the S100B Motif in Edible Plants and Detecting Its Immunoreactive Materials: Perspectives for Functional Foods, Dietary Supplements and Phytotherapies

  • Vincenzo Romano Spica,
  • Veronica Volpini,
  • Federica Valeriani,
  • Giovanni Carotenuto,
  • Manuel Arcieri,
  • Serena Platania,
  • Tiziana Castrignanò,
  • Maria Elisabetta Clementi and
  • Fabrizio Michetti

11 September 2024

The protein S100B is a part of the S100 protein family, which consists of at least 25 calcium-binding proteins. S100B is highly conserved across different species, supporting important biological functions. The protein was shown to play a role in gut...

  • Article
  • Open Access
8 Citations
3,613 Views
19 Pages

4 September 2020

Background and objectives: Anatomical dissection is an indispensable means of acquiring knowledge about the variability of the human body. We detected the co-existence of several arterial variations within one female anatomic specimen during routine...

  • Article
  • Open Access
10 Citations
3,579 Views
17 Pages

Identification of the Intestinal Microbes Associated with Locomotion

  • Ji-Seon Ahn,
  • Yu-Jin Choi,
  • Han-Byeol Kim,
  • Hea-Jong Chung and
  • Seong-Tshool Hong

Given the impact of the gut microbiome on human physiology and aging, it is possible that the gut microbiome may affect locomotion in the same way as the host’s own genes. There is not yet any direct evidence linking the gut microbiome to locom...

  • Article
  • Open Access
3 Citations
3,694 Views
16 Pages

Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages

  • Viviana Cafiso,
  • Stefano Stracquadanio,
  • Veronica Dovere,
  • Flavia Lo Verde,
  • Alessandra Zega,
  • Giuseppe Pigola,
  • Simona Barnini,
  • Emilia Ghelardi and
  • Stefania Stefani

20 November 2021

The treatment of multidrug-resistant Gram-negative infections is based on colistin. As result, COL-resistance (COL-R) can develop and spread. In Acinetobacter baumannii, a crucial step is to understand COL-R onset and stability, still far to be eluci...

  • Article
  • Open Access
789 Views
57 Pages

Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration

  • Georg W. J. Auburger,
  • Jana Key,
  • Suzana Gispert,
  • Isabel Lastres-Becker,
  • Luis-Enrique Almaguer-Mederos,
  • Carole Bassa,
  • Antonius Auburger,
  • Georg Auburger,
  • Aleksandar Arsovic and
  • Nesli-Ece Sen
  • + 1 author

3 February 2026

Polyglutamine expansion in Ataxin-2 (ATXN2) is responsible for rare, dominantly inherited Spinocerebellar Ataxia type 2 (SCA2). Together with its paralog Ataxin-2-like (ATXN2L), both proteins have received much interest, since the deletion of their y...

  • Review
  • Open Access
80 Citations
15,273 Views
23 Pages

Adaptation of Forest Trees to Rapidly Changing Climate

  • Joanna Kijowska-Oberc,
  • Aleksandra M. Staszak,
  • Jan Kamiński and
  • Ewelina Ratajczak

21 January 2020

Climate change leads to global drought-induced stress and increased plant mortality. Tree species living in rapidly changing climate conditions are exposed to danger and must adapt to new climate conditions to survive. Trees respond to changes in the...

  • Article
  • Open Access
4 Citations
4,087 Views
14 Pages

miR398 Attenuates Heat-Induced Leaf Cell Death via Its Target CSD1 in Chinese Cabbage

  • Biting Cao,
  • Jianxia Jiang,
  • Jinjuan Bai,
  • Xuan Wang,
  • Yajie Li,
  • Wenna Shao,
  • Shengwu Hu,
  • Yuke He and
  • Xiang Yu

Previous research has shown that miR398 contributed to plant thermotolerance by silencing its target gene COPPER/ZINC SUPEROXIDE DISMUTASE1 (CSD1) in Arabidopsis thaliana. However, the phylogenesis of miR398 and CSD1 in Brassica crop and their role i...

  • Article
  • Open Access
17 Citations
6,941 Views
18 Pages

Estimation of Genome Size in the Endemic Species Reseda pentagyna and the Locally Rare Species Reseda lutea Using comparative Analyses of Flow Cytometry and K-Mer Approaches

  • Fahad Al-Qurainy,
  • Abdel-Rhman Z. Gaafar,
  • Salim Khan,
  • Mohammad Nadeem,
  • Aref M. Alshameri,
  • Mohamed Tarroum,
  • Saleh Alansi,
  • Naser B. Almarri and
  • Norah S. Alfarraj

3 July 2021

Genome size is one of the fundamental cytogenetic features of a species, which is critical for the design and initiation of any genome sequencing projects and can provide essential insights in studying taxonomy, cytogenetics, phylogenesis, and evolut...

  • Article
  • Open Access
21 Citations
4,634 Views
35 Pages

Classification and Validation of Spatio-Temporal Changes in Land Use/Land Cover and Land Surface Temperature of Multitemporal Images

  • Vimala Kiranmai Ayyala Somayajula,
  • Deepika Ghai,
  • Sandeep Kumar,
  • Suman Lata Tripathi,
  • Chaman Verma,
  • Calin Ovidiu Safirescu and
  • Traian Candin Mihaltan

25 November 2022

Land transfiguration is caused by natural as well as phylogenesis-driving forces, and its consequences for the regional environment are a significant issue in understanding the relationship between society and the environment. Land use/land cover pla...

  • Review
  • Open Access
8 Citations
5,475 Views
16 Pages

The Role of Helicobacter pylori Heat Shock Proteins in Gastric Diseases’ Pathogenesis

  • Olga Maria Manna,
  • Celeste Caruso Bavisotto,
  • Melania Ionelia Gratie,
  • Provvidenza Damiani,
  • Giovanni Tomasello and
  • Francesco Cappello

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human stomach and is associated with several gastric diseases, including gastritis, peptic ulcer disease, and gastric cancer. The bacterium’s ability to thrive in t...