4,415 Results Found

As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and inte...

Fused deposition modeling (FDM) three-dimensional (3D) printing is being increasingly explored as a direct manufacturing method to product pharmaceutical solid dosage forms. Despite its many advantages as a pharmaceutical formulation tool, it remains...

In this work, a hybrid MPC (model predictive control)-PID (proportional-integral-derivative) control system has been designed for the continuous purification and processing framework of active pharmaceutical ingredients (APIs). The specific unit oper...

The increasing resistance of Candida tropicalis to conventional antifungal agents has necessitated the development of effective, biocompatible alternatives derived from natural sources. Garlic (Allium sativum), known for its potent antimicrobial acti...

Objective: This article investigated the structural characteristics, powder properties, and performance variations of co-processed pregelatinized starch (PS) and microcrystalline cellulose (MCC) at varying ratios. Methods: Scanning Electron Microscop...

As one of the most influential industries in public health and the global economy, the pharmaceutical industry is facing multiple challenges in drug research, development and manufacturing. With recent developments in artificial intelligence and mach...

A large variety of pharmaceutical compounds have recently been detected in wastewater and natural water systems. This review highlighted the significance of removing pharmaceutical compounds, which are considered indispensable emerging contaminants,...

The presence of pharmaceuticals in aquatic ecosystems is an issue of increasing concern. Regardless of the low concentration of pharmaceuticals in water, they can have a toxic effect on both humans and aquatic organisms. Advanced oxidation processes...

In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their distribution and behavior of the pharmaceuticals. The examination of...

The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are dis...

Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to...

This article describes the development of a reaction database with the objective to collect data for multiphase reactions involved in small molecule pharmaceutical processes with a search engine to retrieve necessary data in investigations of reactio...

Model-based concepts have been proven to be beneficial in pharmaceutical manufacturing, thus contributing to low costs and high quality standards. However, model parameters are derived from imperfect, noisy measurement data, which result in uncertain...

The invoicing process is critical to the financial management of organizations. However, modeling this process presents challenges such as data updating, information availability, and aligning planned activities with the actual execution of the proce...

Integrated API and drug product processing enable molecules with high clinical efficacy but poor physicochemical characteristics to be commercialized by direct co-processing with excipients to produce advanced multicomponent intermediates. Furthermor...

Although the competence level in pharmaceutical cold chain logistics is adequate in the current healthcare sector, the future will be more unpredictable, disruptive, and chaotic than the world of today because of rapid technological changes, as well...

Target-specific biomolecules, monoclonal antibodies (mAb), proteins, and protein fragments are known to have high specificity and affinity for receptors associated with tumors and other pathological conditions. However, the large biomolecules have re...

The removal of three acid pharmaceuticals—clofibric acid (CLA), diclofenac (DCL), and indomethacin (IND)—by a biological-photocatalytic sequential system was studied. These pharmaceutical active compounds (PhACs) are considered to persist...

Background: The quality of decision-making processes is increasingly recognized as critical to public trust and policy sustainability. Objectives: This narrative review aims to identify and describe process-focused decision support models (DSMs) appl...

A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufacturing process...

Nowadays, the research on the environmental applications of electrochemistry to remove recalcitrant and priority pollutants and, in particular, drugs from the aqueous phase has increased dramatically. This literature review summarizes the application...

The measurement of product temperature is one of the methods that can be adopted, especially in the pharmaceutical industry, to monitor the freeze-drying process and to obtain the values of the process parameters required by mathematical models usefu...

To increase manufacturing flexibility and system understanding in pharmaceutical development, the FDA launched the quality by design (QbD) initiative. Within QbD, the design space is the multidimensional region (of the input variables and process par...

Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination reactions have given opportunities to elegantly make pharmaceutical ingredients. Indeed, these r...

Pharmaceutical contamination poses growing environmental risks, yet industrial adoption of advanced oxidation processes (AOPs) remains limited by high costs and the environmental impacts associated with specialized electrodes. This study demonstrates...

As emerging pollutants, pharmaceutical and personal care products (PPCPs) have received extensive attention due to their high detection frequency (with concentrations ranging from ng/L to μg/L) and potential risk to aqueous environments and human...

Including an active participation of stakeholders along the transportation decision-making process is increasingly recognized as a necessary condition for reaching successful and high-quality decisions. This paper presents a framework for deciding on...

A municipal wastewater treatment plant (WWTP) is a melting pot of numerous pharmaceuticals and personal care products (PPCPs) together with many other substances. The removal of PPCPs using advanced oxidation processes within a WWTP is one way to red...

To produce high-quality pharmaceuticals, a real-time monitoring method for the high-shear wet granulation process (HSWG) was developed based on near-infrared spectroscopy (NIRS). Samples consisting of lactose, potato starch, and hydroxypropyl cellulo...

This study developed an extended model of goal-direct behavior (EMGB) to investigate the role of non-pharmaceutical interventions (NPIs) in predicting latent cruise travelers’ decision-making process in the COVID-19 pandemic context to foster the gro...

Over the last decade, the conical mill has emerged as a potential piece of equipment to use for continuous dry coating pharmaceutical powders. In this work, silicon dioxide was used as a guest particle on two excipients, fast flow lactose (FFL) and g...

In this study, an AM-based continuous processing reactor system was designed, manufactured, and assembled on a laboratory scale for the generation of pharmaceutical substances with an improved process control. The developed AM-based (additively manuf...

Rabies remains a persistent zoonotic threat, particularly in regions where domestic dogs are the main source of human and animal infections. This mathematical model studies the dynamics of rabies transmission between canine populations (dog-to-dog) a...

The widespread introduction of antibiotics into medical practice, starting in the late 1940s and early 1950s, radically transformed healthcare, raised it to a qualitatively new level, allowed saving human lives in previously hopeless situations, and...

Due to various potential toxicological threats to living organisms even at low concentrations, pharmaceuticals and personal care products in natural water are seen as an emerging environmental issue. The low efficiency of removal of pharmaceuticals a...

Pharmaceuticals are biologically active compounds used for therapeutical purposes in humans and animals. Pharmaceuticals enter water bodies in various ways and are detected at concentrations of ng L⁻¹–μg L⁻¹. Their presence in th...

In this work, the degradation of the pharmaceutical losartan, in simulated fresh urine (which was considered because urine is the main excretion route for this compound) by sonochemistry and UVC/H₂O₂ individually, was studied. Initially, special atte...

The judicious use of buffering capacity is important in the development of future continuous pharmaceutical manufacturing processes. The potential benefits are investigated of using optimal-averaging level control for tanks that have buffering capaci...

The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being co...

Drug R&D innovation contributes to the high-quality development of the pharmaceutical industry, which is related to people’s life and health, economic development, and social stability. Tax incentives and industry cooperation are conducive...

The presence of pharmaceuticals in the aquatic environment presents a challenge to modern science. The most significant impact this can induce is the emergence of antibiotic resistance, which can lead to a global health emergency. It is important to...

The development and application of emerging technologies of Industry 4.0 enable the realization of digital twins (DT), which facilitates the transformation of the manufacturing sector to a more agile and intelligent one. DTs are virtual constructs of...

Several nanomedicine based medicinal products recently reached the market thanks to the drive of the COVID-19 pandemic. These products are characterized by criticality in scalability and reproducibility of the batches, and the manufacturing processes...

The Electro-Fenton (E-Fenton) technique has shown great potential in wastewater treatment, while the sustainable and continuing supply of Fe2⁺ remains challenging. Herein, we demonstrate the construction of a novel E-Fenton system by magnetically dec...

Pharmaceutical industry effluents often contain high concentrations of refractory organic solvents, chemical oxygen demand (COD), and total dissolved solids (TDSs). These wastewaters, including N-containing organic solvents known for their persistenc...

Taste masking in pharmaceutical products is a complex and subjective process that requires reliable evaluation methods. This review focuses on the electronic tongue (e-tongue), an emerging sensor-based technology designed to mimic human taste percept...

Hydroxyl radical (•OH) scavenging demand can be an indicator that represents the water quality characteristics of raw water. It is one of the key parameters predicting UV/H₂O₂ system performance and affects the operating parameters. Based on the...

The incessant release of pharmaceuticals into the aquatic environment continues to be a subject of increasing concern. This is because of the growing demand for potable water sources and the potential health hazards which these pollutants pose to aqu...

In all production processes of solid dosage forms, powders with a multitude of distributed properties must be processed [...]

Introduction: Deficits of self-regulation (SR) are a hallmark of externalizing (EXT: offending or aggressive behaviors) symptoms in adolescence. Objectives: This scoping review aims (1) to map non-pharmaceutical interventions targeting SR processes t...