Search Results (1,631)

Ensuring uninterrupted access to essential medicines in public healthcare systems is a persistent challenge with clinical, economic, and environmental implications. Oncology services are particularly vulnerable to stockouts, which compromise therapeutic continuity and increase reliance on urgent procurement with high carbon and waste footprints. This study proposes a risk-informed, data-driven framework for pharmaceutical inventory governance in a high-complexity public oncology hospital in Chile, aligning with sustainability goals and green supply chain principles. Using operational data from 2023–2024, we integrate descriptive analytics, ABC–XYZ segmentation, and a continuous-review (s, Q) policy extended through a Logistic Risk Index (LRI) that consolidates demand variability, supply performance, and clinical-economic criticality. Empirical analysis reveals strong expenditure concentration in AX/AY segments and significant misalignment between institutional and analytically derived parameters. A Monte Carlo simulation N = 1000 runs per scenario) compares baseline, adjusted, and fully risk-informed policies under stochastic demand and lead-time conditions. Results show that the risk-informed configuration reduces stockout exposure by up to 46%, improves fill rates (93.1% → 96.4%), and shortens replenishment delays, while maintaining total logistic cost stability. Critically, urgent orders decrease from 27.4 to 14.8 per year, avoiding an estimated 630 kg CO₂ emissions and 25 kg of packaging waste annually. These findings demonstrate that resilience, efficiency, and sustainability are not competing objectives but can be jointly achieved through integrated analytics and governance. The proposed approach offers a scalable blueprint for public health systems seeking to transition from reactive inventory management toward anticipatory, transparent, and sustainability-oriented decision-making, contributing to SDG 3 (health and well-being) and SDG 12 (responsible consumption and production). Full article

With the increasing importance of cultural consumption and the sustainable revitalization of intangible cultural heritage (ICH), visual communication has become a key mechanism for translating cultural meanings into contemporary branding contexts. This study develops a semiotics-informed structural model that integrates semiotic theory with consumer behavior frameworks to explain how cultural visual symbols influence brand preference through cultural cognition and cultural identity. Using Wufangzhai as an empirical case, partial least squares structural equation modeling (PLS-SEM) is applied to survey data from 274 consumers. The results indicate that different visual elements exert differentiated effects on cultural cognition, with color and packaging showing stronger influences, while typography plays a more significant role in shaping cultural identity. Cultural identity is also found to mediate the relationship between cultural cognition and brand preference. These findings contribute to cultural branding research and provide practical insights for the design of ICH visual communication systems. Full article

Painho de Porco Preto is a traditional product of the Alentejo region, made with cuts of Alentejano autochthonous breed pigs. The objective of this study was to evaluate how different storage temperatures (4 °C and room temperature (20 ± 2 °C)) could influence the quality and safety of the sliced vacuum-packed Painho de Porco Preto, throughout 6 months of storage. Analyses included physicochemical parameters, microbiological, and sensory analysis. Throughout storage, the product showed low TBARS values (<3 MDA/kg) and stable tocopherol levels under both storage conditions, although the samples at room temperature performed slightly better. a_w and pH values were higher for samples stored at 4 °C, which influenced the results of some parameters. Color coordinate b* had an increase in values by the end of storage for the fat portion of the slices, but the rest of the parameters stayed stable. Nitrate/nitrite contents remained within expected ranges for dry-cured sausages. Microbiological analyses confirmed the absence of major pathogens during the study period, while variations in growth were observed depending on storage temperature. In sum, the results indicate that sliced vacuum-packaged Painho de Porco Preto can maintain acceptable quality and safety for 6 months at room temperature. These findings provide useful information for the meat industry by supporting the optimization of storage strategies and shelf-life management for sliced traditional dry-cured sausages. Full article

Climate hazards increasingly disrupt schooling, revealing the limits of preparedness models that treat teachers only as implementers. This study reframes teacher empowerment as a climate-resilience capability and examines how governance arrangements enable (or constrain) hazard-ready education systems. Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), searches of Web of Science, Scopus, and Google Scholar (2000–2025) identified 53 eligible studies. Across diverse hazards and settings, the evidence converges on a governance-to-capability pathway: empowerment becomes resilient performance only when the delegated decision space is matched with financed capacity (time, training, contingency resources), timely risk information and functional communication/digital infrastructure, institutionalized cross-sector coordination (education–DRR–health–protection–local government), and learning-oriented accountability (after-action review and adaptive revision rather than punitive compliance). Reported outcomes include higher preparedness quality, earlier protective action, improved learning continuity and safeguarding, and more sustainable teacher well-being/retention. Predictable failure modes include mandate–resource mismatch, accountability overload, unstable centralization–autonomy dynamics, and inequitable empowerment distribution affecting rural schools, women, and contract teachers, and disability inclusion. The evidence gaps remain pronounced for chronic hazards (especially heat and wildfire smoke), high-vulnerability contexts (fragile/conflict settings and informal settlements), and standardized measures of equity, burden distribution, governance performance, and cost-effectiveness. Policies should prioritize integrated governance packages with explicit protection and equity safeguards. Full article

This study employs a constructivist grounded theory approach based on 69 in-depth interviews conducted between March 2022 and December 2023 to examine socio-cognitive dynamics in Korea’s bottled water and household water purifier markets. The study addresses a gap in prior research by explaining how product meanings and stakeholder strategies co-evolve across adjacent “safe-water” markets under regulatory and sustainability pressures. Drawing on qualitative data from 69 stakeholders, including producers (n = 30), consumers (n = 19), and institutional experts (n = 20), we analyze how distrust, risk perception, and health consciousness reshape conceptual systems and market strategies. These shifts drive innovation across markets, including new technologies, service models, and branding strategies. The findings show that socio-cognitive stabilization arises through iterative interactions among institutional shocks, producer reinterpretation, and consumer adaptation. In the bottled water market, the meanings of “natural purity” became materially embedded in packaging, mineral labeling, and brand narratives. In the purifier sector, “technological reliability” was institutionalized through service-based maintenance systems and visible quality control technologies. These processes developed within asymmetric communicative environments shaped by corporate branding capacity and media amplification. This study refines socio-cognitive market theory by specifying boundary conditions under institutional distrust in developed economies. Although Republic of Korea possesses advanced drinking water infrastructure comparable to that of other developed economies, public confidence in tap water has periodically weakened following highly salient contamination incidents and regulatory transitions. This paradox provides a theoretically informative context for examining how product meanings and stakeholder behaviors mutually adapt over time. Although environmental impact metrics were not directly measured, the findings suggest that sustainability policies must address socio-cognitive trust dynamics alongside regulatory instruments such as plastic levies, certification schemes, and transparent risk communication. Full article

The antimicrobial effect of Chios mastic gum essential oil (mastic EO) was evaluated in vitro in a variety of spoilage and pathogenic bacteria and yeast strains isolated from spoiled cheeses with concentrations ranging from 0.006 to 2% (Minimum Inhibitory Concentration (MIC)) and in situ (cheese slices). The mastic EO (2%) was incorporated in sodium alginate edible gel films (Mastic Edible Films (MEFs)), and then the films were applied between the cheese slices that had been previously inoculated with a cocktail of three strains of Listeria monocytogenes (on both sides of the slices) and subjected or not to high-pressure processing (HPP). Cheese samples were vacuum-packaged and cold stored (4 °C), and microbiological, pH and organoleptic (in pathogen-free slices) analyses were employed, while Fourier Transform Infrared (FTIR) spectroscopy was applied as a rapid technique to monitor the biochemical changes present on the slices. Samples without MEF, without the pathogen and with or without HPP were employed as controls. Results showed that the MIC of the mastic EO varied from 0.01% to 1.8% depending on the species and/or strains. Pathogen’s growth was suppressed by HPP, MEF or their combination, which showed the highest efficacy. These results could provide useful data to support risk assessment studies on ready-to-eat foods. Finally, FTIR implementation with data analytics was found to be satisfactory, indicating FTIR’s potential as a reliable information source for cheese quality control. Full article

A thorough understanding of the microbial ecology of meat products, dominated by critical pathogens such as Salmonella spp., Campylobacter jejuni, Escherichia coli, and Listeria monocytogenes, and marked by risks of resistant biofilm formation and vulnerabilities specific to informal commercial sectors, underscores the need to transition from conventional inert barriers to active nanostructured packaging systems. This review critically analyses the current state of antimicrobial nanomaterials, dissecting their molecular mechanisms of action and dynamic interactions designed to preserve sensory and nutritional food quality. Beyond technical effectiveness, the paper highlights the inherent tension between technological innovation and toxicological uncertainties, addressing major challenges related to migration kinetics in complex lipid matrices and the uneven global regulatory landscape. Main limitations of frequently investigated materials, along with regulatory discrepancies among international authorities and safety variables, are discussed to contextualise the current barriers to industrial implementation. We conclude that although nanotechnology represents a transformative force for extending shelf life, safety validation through rigorous assessment of migration remains imperative to harmonise scientific progress with public health protection. This integrative perspective highlights the imperative of calibrating nanostructural architecture to the bioactive profile, providing strategic design directions essential for the sustainable translation of experimental innovation to industrial scale. Full article

The increasing deployment of collaborative and industrial robots in manufacturing systems places high demands on equipment reliability, availability, and maintenance efficiency. Robotic workcells, in which multiple automated subsystems operate in tightly coordinated cycles, are particularly sensitive to unplanned downtime, as failures of individual components can disrupt the entire production process. Traditional time-based preventive maintenance is often insufficient under such conditions, as it does not adequately reflect actual operating loads or component degradation. This paper proposes a structured framework for the design of an integrated maintenance concept for a multi-robot packaging workcell. The framework systematically combines component identification, criticality assessment, and the selection of appropriate maintenance strategies, including preventive, predictive, corrective, proactive, and reactive approaches. Preventive maintenance is complemented by condition-based monitoring and trend analysis of selected diagnostic parameters, enabling predictive decision-making for critical components. The proposed methodology further integrates maintenance planning and performance evaluation through a computerized maintenance management system (CMMS), supporting the coordination of maintenance activities and the assessment of key performance indicators. The novelty of the proposed framework lies primarily in the dynamic allocation of maintenance strategies based on semi-quantified component criticality and in the structured integration of predictive diagnostic information with CMMS-supported maintenance planning. Unlike traditional RCM-based or single-strategy maintenance approaches, the framework enables coordinated preventive, predictive, corrective, proactive, and reactive actions within a unified decision-making architecture, supporting proactive continuous improvement of maintenance performance through a closed-loop feedback mechanism that updates component criticality based on real-time operational data. The framework is demonstrated on a robotic workcell comprising a collaborative robot, an industrial robot, pneumatic subsystems, and a centralized control architecture. The results suggest that the integrated approach may provide a coherent basis for reducing reactive maintenance actions, improving system availability, and supporting data-driven maintenance planning. As a conceptual framework with partial (pilot) practical implementation within the context of this paper, the proposed approach establishes a foundation for future broader implementation, experimental validation and the integration of advanced diagnostic and prognostic methods, mainly in the context of multi-Robot workcell and production process maintenance. Full article

Background: Fixed-dose combination drugs (FDCs) are combinations of two or more active ingredients in a single dosage form. These formulations have proven effective in combating the development of resistance in diseases such as tuberculosis and malaria. Despite the benefits observed in the aforementioned cases, fixed-dose antibiotics combinations (FDACs) are increasingly raising questions about their rationality. This is the case for several FDACs listed in the AWaRe classification as not recommended, which unfortunately remain available on the pharmaceutical market, particularly in low- and middle-income countries like the Democratic Republic of Congo (DRC). Objectives: To identify the essential medicines available in pharmacies open to the public in the city of Kinshasa and to assess their inclusion in the DRC’s National List of Essential Medicines (NLEM) and in the World Health Organization’s (WHO) List of Essential Medicines (LEM). The rationality of the FDACs circulating in the city of Kinshasa were also evaluated based on the 2023 AWaRe classification. Methods: A cross-sectional and descriptive study was conducted between February and October 2025 in Kinshasa. For this purpose, fifty registered pharmacies open to the public were selected by systematic random sampling as the research sample. Data collection consisted of completing a data collection form after we had provided the pharmacies’ owners with the necessary explanations regarding the importance of the study and guaranteed their anonymity. Results: The controlled FDACs encountered comprised 27 specialties across 15 different formulations. Out of 15 formulations, 12 (80%) were included on the WHO list of non-recommended antibiotics and were not included in the DRC’s NLEM nor in the WHO’s LEM. Some had been withdrawn from the market in their countries of manufacture. Of the 15 FDACs evaluated for their rationality and compliance, the injectable FDACs presented problems related to the relevance and completeness of information contained on their packaging. On their primary packaging, there was a significant difference in the expiration dates of the powder and sterile water for injection contained in the combination pack, ranging from 6 to 36 months. Furthermore, the secondary packaging lacked data related to the sterile water for injection contained in the combination pack. In addition, several medications contained the same therapeutic combination. For injectable FDAC, for example, the combination Ceftriaxone-Sulbactam was represented by eight medications. For oral FDACs, the combination Sulfamethoxazole-Trimethoprim was represented by seven medications. Globally, 100% of these drug combinations originated from India. Conclusions: Fifteen varieties of FDACs were available in Kinshasa, most of which (80%) were unsuitable. It is important that public health authorities address this situation and develop stricter guidelines for granting marketing authorizations, particularly for FDACs. Full article

Food safety can be regarded as a critical aspect of consumer protection, and there is a clear need for related research within the context of food delivery apps. In addition, food safety is a multidimensional concept, and its definition may vary depending on the specific context in which it is examined. Therefore, this work investigates food safety in the case of food delivery apps from the perspective of consumers in the Korean market. Food safety was conceptualized through four sub-dimensions: food healthiness, eco-friendly packaging, review information, and hygiene. The study examined the effects of these four factors on trust in food delivery apps and the influence of trust on continuance intention. Also, this work inspects the moderating role of hygiene in the relationship between trust and continuance intention. The survey participants were recruited via an online survey conducted through a professional research firm, yielding 300 valid responses. Hypotheses were tested using structural equation modeling and Hayes’ Process Macro Model 1. The results show that trust is positively influenced by eco-friendly packaging, review information, and hygiene. Additionally, trust significantly affects continuance intention, with hygiene demonstrating a significant moderating effect. This research contributes to the literature by clarifying the definition of food safety in food delivery apps and elucidating the relationships among its key sub-dimensions. Full article

To continuously improve the efficiency of the construction project delivery process, various innovative methods and technologies have been developed and adopted in the past decades. Among these methods, modular construction has become a popular option due to its short on-site installation time generated by off-site prefabrication. However, the process of modular construction requires a highly integrated system to accurately connect multiple phases, including material packaging, transportation logistics, locating and tracking, and on-site installation. Accordingly, this process typically poses a significant challenge for contractors to efficiently manage the materials needed for daily tasks. This paper introduces a construction material management system that integrates every phase from off-site packaging to on-site installation. The integrated system was developed based on Logistic Chain and Building Information Modeling (BIM) using a three-layer framework, namely material packaging, inventory management, and material locating and tracking. The new system utilizes recent innovative technologies for transparent consolidation and highly efficient operation of off-site inventory management and on-site visualization. The developed system was further examined in a real-world case study project. The material handling time was then analyzed and compared with benchmark data without using the integrated system. The results indicated that the newly developed system was able to effectively reduce the time of locating materials and the rate of missing materials during on-site installation. In addition, this case study project added value to the verification of the broader system’s capabilities for inventorying, tracking, and visualizing construction materials. The findings of this project provide valuable knowledge and insight into improving construction efficiency through an integrated material management system. Future research is needed to expand the applicability of multiple framework designs and assess the cost–benefit analysis for production-scale and commercial use. Full article

Hybrid railway assets such as workshops and depots combine building, mechanical, electrical and plumbing (MEP)/industrial, and linear infrastructure domains, increasing coordination complexity and challenging continuity from the Project Information Model (PIM) to the Asset Information Model (AIM). Although Employer’s Information Requirements (EIR), Asset Information Requirements (AIR), and the BIM Execution Plan (BEP) prescribe deliverables and processes, a persistent gap remains between documentary prescriptions and the auditable evidence needed to support traceable decisions within the Common Data Environment (CDE). This paper proposes an ISO 19650-aligned governance framework that operationalizes the EIR/AIR → BEP → CDE transition by: (i) structuring the asset using Functional Units (FUs) as a stable anchor for PIM → AIM continuity; and (ii) implementing a pre-Published Quality Gate that separates control into three non-substitutable dimensions (spatial, semantic, and data). The approach is implemented as a tool-neutral, reproducible workflow (inputs → checks → outputs → publish) and produces a minimal, persistent evidence package in the CDE (file-level report, package summary, publish/hold decision record, and Nonconformity Report (NCR)/BIM Collaboration Format (BCF) traceability), with explicit roles governing the Shared → Published transition. Across 22 Industry Foundation Classes (IFC), deliverables from two depot cases and multiple delivery states, All Gates Pass ranged from 25.0% to 44.4% depending on Case × State; overall, 14/22 deliverables (63.6%) would be held pending correction under the gate. Although validated on Spanish railway depots, the framework is grounded in ISO/openBIM standards and is designed for transferability to other international contexts and complex asset types where multidisciplinary federation and PIM → AIM continuity pose similar challenges. Full article

Quantum metrology uses the principles of quantum mechanics to improve the accuracy of parameter estimation so that it can surpass the classical limit. However, noise and the challenge of preparing multipartite entangled states hinder practical applications. In this work, we use the Lipkin-Meshkov-Glick model as the experimental platform and the quantum parameter estimation package QuanEstimation as a tool to improve the quantum parameter estimation in many-body systems by using Hamiltonian control optimization. We apply auto-GRAPE, PSO, and DE algorithm to optimize the time-dependent control field. Our results show that the optimal control strategy can significantly enhance the quantum Fisher information and reduce the quantum Cramér-Rao bound even under environmental noise. These findings provide a way to achieve the parameter estimation limit in a noisy environment and promote the development of practical quantum metrology applications. Full article

The problem of multi-criteria selection of network security configurations (NSC) under resource constraints and the necessity to comply with information security (IS) policies is addressed in this study. A formal mathematical model of the problem has been developed, encompassing the definition of a set of possible security mechanism configurations, the formalization of objective functions reflecting security levels, throughput, and deployment costs, and the introduction of constraints on feasible solutions. The NSGA-II (Non-dominated Sorting Genetic Algorithm II) optimization algorithm is employed to generate a set of Pareto-optimal solutions, ensuring uniform coverage of compromise configurations. A software package implemented in Python 3 incorporates modules for population generation, fitness evaluation, selection, crossover, mutation operators, and result visualization. Computational experiments (CE) were conducted to validate the effectiveness of the proposed approach. The evolution dynamics of the Pareto hypervolume were analyzed, the uniformity of solution distribution in the objective space was studied, and the impact of algorithm parameters on convergence to the optimal solution was examined. The results demonstrate that the proposed methodology enables the formation of NSC sets that achieve a balanced trade-off between security, throughput, and IS system deployment costs. Full article

Growing global environmental awareness has fueled a “green” market, but also a confusing array of information, raising risks of misinformation. In response, sustainability certifications and instruments have become crucial tools in the cosmetics industry. However, the rapid spread of these ecolabels has created new problems, including market fragmentation, consumer confusion, and heightened concerns about greenwashing. This study conducts a systematic comparative analysis of 24 prominent sustainability schemes within the cosmetics sector. We developed an analytical framework to assess each instrument across three dimensions: (i) value chain coverage (from sourcing to end-of-life), (ii) corporate sustainability scope (environmental, social, governance), and (iii) verification and transparency mechanisms. The results reveal a fragmented landscape with significant scope imbalances. Most instruments robustly cover upstream impacts (e.g., ingredient sourcing), but downstream phases—including consumer use, packaging, and circularity—are markedly under-addressed. At the corporate level, environmental criteria dominate, with social and governance dimensions inconsistently integrated. Verification rigor and transparency vary widely, with many relying on confidential audits or self-declaration. In conclusion, while valuable as market instruments, prevailing certifications are insufficient as standalone assurance tools. The findings highlight a misalignment with emerging regulations, underscoring the need for greater lifecycle integration, enhanced transparency, and alignment with comprehensive corporate sustainability frameworks. Full article