Search Results (7,887)

Background: Parkinson’s disease (PD) often involves autonomic dysfunction, most notably impaired baroreflex sensitivity (BRS), which disrupts cardiovascular homeostasis and contributes to orthostatic hypotension (OH). Pharmacological and invasive treatments, including deep brain stimulation, have yielded inconsistent benefits and carry procedural risks, highlighting the need for safer, more accessible alternatives. In this systematic review, we evaluated non-invasive interventions—spanning somatosensory stimulation, exercise modalities, thermal therapies, and positional strategies—aimed at improving cardiovascular autonomic function in PD. Methods: We searched PubMed, Embase, MEDLINE (Ovid), Google Scholar, ScienceDirect, and Web of Science for studies published between January 2014 and December 2024. Eight original studies (n = 8) including 205 participants met the inclusion criteria for analyzing cardiac sympathovagal balance. Results: Five studies demonstrated significant post-intervention increases in BRS. Most reported favorable shifts in heart rate variability (HRV) and favorable changes in the low-frequency/high-frequency (LF/HF) ratio. Across modalities, systolic blood pressure (SBP) decreased by an average of 5%, and some interventions produced benefits that persisted up to 24 h. Conclusion: Although sample sizes were small and protocols heterogeneous, the collective findings support the potential of non-invasive neuromodulation to enhance BRS and overall cardiovascular regulation in PD. Future research should focus on standardized, higher-intensity or combined protocols with longer follow-up periods to establish durable, clinically meaningful improvements in autonomic function and quality of life for people living with PD. Full article

Soil microbial communities are crucial for ecosystem services, soil fertility, and the resilience of agroecosystems. This study investigated how long-term (31 years) agronomic practices—tillage, NPK fertilization, and cropping system—along with measured environmental variables influence the microbial biomass and its community composition in Chernozem soil under corn cultivation. The polyfactorial field experiment included three tillage treatments ((moldboard (MT), ripped (RT), strip (ST)), two fertilization regimes (NPK (N: 160; P: 26; K: 74 kg/ha), and unfertilized control) and two cropping systems (corn monoculture and corn–wheat biculture). The soil samples (0–30 cm) were collected in June and September 2023. Microbial biomass and community structure were quantified using phospholipid fatty acid (PLFA) analysis, which allowed the estimation of total microbial biomass and community composition (arbuscular mycorrhizal (AM) fungi, fungi, Gram-negative (GN) and Gram-positive (GP) bacteria, actinomycetes). Our results showed that microbial biomass increased from June to September, rising by 270% in unfertilized plots and by 135% in NPK-fertilized plots, due to higher soil moisture. Reduced tillage, especially ST, promoted significantly higher microbial biomass, with biomass reaching 290% and 182% of that in MT plots in June and September, respectively. MT had a higher ratio of bacteria-to-fungi compared to RT and ST, indicating a greater sensitivity of fungi to disturbance. NPK fertilization lowered soil pH by about one unit (to 4.1–4.8) and reduced microbial biomass—by 2% in June and 48% in September—compared to the control, with the particular suppression of AM fungi. The cropping system had a smaller overall effect on microbial biomass. Full article

The Tibetan-Himalayan region, recognized as a global biodiversity hotspot, is increasingly threatened by the dual pressures of climate change and human activities. Understanding the vulnerability of plant species to these forces is crucial for effective ecological conservation in this region. This study employed an improved Climate Niche Factor Analysis (CNFA) framework to assess the vulnerability of six representative alpine endemic herbaceous plants in this ecologically sensitive region under future climate changes. Our results show distinct spatial vulnerability patterns for the six species, with higher vulnerability in the western regions of the Tibetan-Himalayan region and lower vulnerability in the eastern areas. Particularly under high-emission scenarios (SSP5-8.5), climate change is projected to substantially intensify threats to these plant species, reinforcing the imperative for targeted conservation strategies. Additionally, we found that the current coverage of protected areas (PAs) within the species’ habitats was severely insufficient, with less than 25% coverage overall, and it was even lower (<7%) in highly vulnerable regions. Human activity hotspots, such as the regions around Lhasa and Chengdu, further exacerbate species vulnerability. Notably, some species currently classified as least concern (e.g., Stipa purpurea (S. purpurea)) according to the IUCN Red List exhibit higher vulnerability than species listed as near threatened (e.g., Cyananthus microphyllus (C. microphylla)) under future climate change. These findings suggest that existing biodiversity assessments, such as the IUCN Red List, may not adequately account for future climate risks, highlighting the importance of incorporating climate change projections into conservation planning. Our study calls for expanding and optimizing PAs, improving management, and enhancing climate resilience to mitigate biodiversity loss in the face of climate change and human pressures. Full article

Cancer and infectious diseases are major causes of global morbidity and mortality stressing the need to find novel drugs with promising dual anticancer and antimicrobial efficacy. Gold complexes have been studied for the past years due to their anticancer properties, with a few of them displaying antimicrobial properties, which support their pharmacological interest. Within this scope, we investigated six gold bisdithiolate complexes [Au (bdt)₂]⁻ (1), [Au (dcbdt)₂]⁻ (2), [Au (3-cbdt)₂]⁻ (3), [Au (4-cbdt)₂]⁻ (4), [Au (pdt)₂]⁻ (5) and [Au (dcdmp)₂]⁻ (6), and) against the ovarian cancer cell lines A2780 and A2780cisR, the Gram-positive bacteria Staphylococcus aureus Newman, the Gram-negative bacteria Escherichia coli ATCC25922 and Burkholderia contaminans IST408, and the pathogenic yeasts Candida glabrata CBS138 and Candida albicans SC5134. Complexes 2 and 6, with ligands containing aromatic pyrazine or phenyl rings, substituted with two cyanonitrile groups, showed after 24 h of incubation high anticancer activities against A2780 ovarian cancer cells (IC₅₀~5 µM), being also able to overcome cisplatin resistance in A2780cisR cells. Both complexes induced the formation of ROS, activated caspase-3/7, and induced necrosis (LDH release) in a dose-dependent way, in a greater extent in the case of 6. Among the bacterial and fungal strains tested, only complex 6 presented antimicrobial activity against S. aureus Newman, indicating that this complex is a potential novel anticancer and antibacterial agent. These results delve into the structure-activity relationship of the complexes, considering molecular alterations such as replacing a phenyl group for a pyrazine group, and the inclusion of one or two cyanonitrile appendage groups, and their effects on biological activity. Overall, both complexes were found to be promising leads for the development of future anticancer drugs against low sensitive or cisplatin resistant tumors. Full article

The increasing demand for sustainable practices in road construction has prompted the search for environmentally friendly and cost-effective materials. This study explores the incorporation of reclaimed asphalt pavement (RAP) and Panasqueira mine waste (greywacke aggregates) as full replacements for virgin aggregates in hot mix asphalt (HMA), aligning with the objectives of UN Sustainable Development Goal 9. Three asphalt mixtures were prepared: a reference mixture (MR) with granite aggregates, and two modified mixtures (M15 and M20) with 15% and 20% RAP, respectively. All mixtures were evaluated through Marshall stability, stiffness modulus, water sensitivity, and wheel tracking tests. The results demonstrated that mixtures containing RAP and mine waste met Portuguese specifications for surface courses. Specifically, the M20 mixture showed the highest stiffness modulus, improved moisture resistance, and the best performance against permanent deformation. These improvements are attributed to the presence of stiff aged binder in RAP and the mechanical characteristics of the greywacke aggregates. Overall, the findings confirm that the combined use of RAP and mining waste provides a technically viable and sustainable alternative for asphalt pavement construction, contributing to resource efficiency and circular economy goals. Full article

The accurate perception of visual stimuli in human–machine systems is crucial for improving system safety, usability, and task performance. The widespread adoption of digital technology has significantly increased the importance of visual interfaces and information. Therefore, it is essential to design visual interfaces and information with user characteristics in mind to ensure accurate perception of visual information. This study employed the Cognitive Perceptual Assessment for Driving (CPAD) to evaluate and compare gender differences in the ability to perceive visual signals within complex visual stimuli. The experimental setup included a computer with CPAD installed, along with a touch monitor, mouse, joystick, and keyboard. The participants included 11 male and 20 female students, with an average age of 22 for males and 21 for females. Prior to the experiment, participants were instructed to determine whether a signal stimulus was present: if a square, presented as the signal, was included in the visual stimulus, they moved the joystick to the left; otherwise, they moved it to the right. Each participant performed a total of 40 trials. The entire experiment was recorded on video to measure overall response times. The experiment measured the number of correct detections of signal presence, response times, the number of misses (failing to detect the signal when present), and false alarms (detecting the signal when absent). The analysis of experimental data revealed no significant differences in perceptual ability or response times for visual stimuli between genders. However, males demonstrated slightly superior perceptual ability and marginally shorter response times compared to females. Analyses of sensitivity and response bias, based on signal detection theory, also indicated a slightly higher perceptual ability in males. In conclusion, although these differences were not statistically significant, males demonstrated a slightly better perception ability for visual stimuli. The findings of this study can inform the design of information, user interfaces, and visual displays in human–machine systems, particularly in light of the recent trend of increased female participation in the industrial sector. Future research will focus on diverse types of visual information to further validate these findings. Full article

Background/Objectives: We sought to characterize the variance and overlap among definitions of Proximal Junctional Kyphosis (PJK) used in the adult spinal deformity (ASD) literature. PJK is defined as excess in PJK angle, a Cobb angle between the upper-instrumented vertebra (UIV) and a supra-adjacent vertebra (SAV), either one (UIV+1) or two (UIV+2) levels rostral of the UIV. No expert consensus exists for threshold angle or which SAV to use. Methods: A total of 116 thoracolumbar fusion patients ≥ 65 years old were reviewed. The UIV+1 and UIV+2 angles were measured. Six definitions of PJK from the literature were evaluated. These definitions were selected based on citation frequency, historical relevance, and accessibility through commonly used databases. Pearson’s Chi-squared and pairwise comparisons were performed to evaluate the distinctness and agreement rates among these definitions. Results: The six definitions of PJK were as follows: [PJK20] PJK angle ≥ 20° with UIV+2 as the (SAV), [PJK10] PJK angle ≥ 10° with a >10° change from pre-op with UIV+2 as the SAV, [PJK2SD] PJK angle > 2 standard deviations from average with UIV+1 as the SAV, [PJK10+10] PJK angle ≥ 10° with a >10° change from pre-op with UIV+1 as the SAV, [PJK15] PJK angle > 15° with UIV+1 as the SAV, and [PJK30] PJK angle > 30° with UIV+2 as the SAV, or displaced rod fracture, or reoperation within 2 years for junctional failure, pseudoarthrosis, or rod fracture. [PJK10] and [PJK2SD] were the most distinct definitions while [PJK20], [PJK10+10], [PJK15], and [PJK30] showed no significant pairwise differences. [PJK2SD] was stringent, while definition [PJK30] included unique diagnostic information not captured by other definitions. Conclusions: The use of [PJK20], [PJK10+10], [PJK15], or [PJK30] is recommended for consistency, with [PJK15] presenting the best balance. Stringent [PJK2SD] may be beneficial for identifying severe PJK, though with low sensitivity. Overall, PJK definitions must be standardized for the consistent reporting of clinical outcomes and research comparability. Full article

Evaluating the renewable energy potential, such as that of solar photovoltaics (PV), is important for developing renewable energy policies. This study investigated rooftop solar PV potential in Thailand based on open-source geographic information system (GIS) building footprints, solar PV power output, and the most recent land use data (2022). GIS-based overlay analysis, buffering, fishnet modeling, and spatial join operations were applied to assess rooftop availability across various building types, taking into account PV module installation parameters and optimal panel orientation. Economic feasibility and sensitivity analyses were conducted using standard economic metrics, including net present value (NPV), internal rate of return (IRR), payback period, and benefit–cost ratio (BCR). The findings showed a total rooftop solar PV power generation potential of 50.32 TWh/year, equivalent to 25.5% of Thailand’s total electricity demand in 2022. The Central region contributed the highest potential (19.59 TWh/year, 38.94%), followed by the Northeastern (10.49 TWh/year, 20.84%), Eastern (8.16 TWh/year, 16.22%), Northern (8.09 TWh/year, 16.09%), and Southern regions (3.99 TWh/year, 7.92%). Both commercial and industrial sectors reflect the financial viability of rooftop PV installations and significantly contribute to the overall energy output. These results demonstrate the importance of incorporating rooftop solar PV in renewable energy policy development in regions with similar data infrastructure, particularly the availability of detailed and standardized land use data for building type classification. Full article

Accurate semantic segmentation of indoor architectural elements, such as staircases and elevators, is critical for safe and efficient robotic navigation, particularly in complex multi-floor environments. Traditional fusion methods struggle with occlusions, reflections, and low-contrast regions. In this paper, we propose a novel feature fusion module, Skip-Connection Fusion (SCF), that dynamically integrates RGB (Red, Green, Blue) and depth features through an adaptive weighting mechanism and skip-connection integration. This approach enables the model to selectively emphasize informative regions while suppressing noise, effectively addressing challenging conditions such as partially blocked staircases, glossy elevator doors, and dimly lit stair edges, which improves obstacle detection and supports reliable human–robot interaction in complex environments. Extensive experiments on a newly collected dataset demonstrate that SCF consistently outperforms state-of-the-art methods, including PSPNet and DeepLabv3, in both overall mIoU (mean Intersection over Union) and challenging-case performance. Specifically, our SCF module improves segmentation accuracy by 5.23% in the top 10% of challenging samples, highlighting its robustness in real-world conditions. Furthermore, we conduct a sensitivity analysis on the learnable weights, demonstrating their impact on segmentation quality across varying scene complexities. Our work provides a strong foundation for real-world applications in autonomous navigation, assistive robotics, and smart surveillance. Full article

This study investigated the nuanced influence of urban morphology on the thermal performance of nine mass housing blocks (21–26, 28–30) in New Belgrade’s Central Zone. These blocks, showcasing diverse structures, provided a robust basis for evaluating the design parameters. ENVI-met simulations were used to assess two scenarios: an “asphalt-only” environment, isolating the urban structure’s impact, and a “real-world” scenario, including green infrastructure (GI). Overall, the findings emphasize that while GI offers mitigation, the inherent urban built structure fundamentally determines thermal outcomes. An urban block’s thermal performance, it turns out, is a complex interplay between morphological factors and local climate. Crucially, simple metrics like Green Area Percentage (GAP) and Building Coverage Ratio (BCR) proved unreliable predictors of thermal performance. This highlights the critical need for urban planning regulations to evolve beyond basic surface indicators and embrace sophisticated, context-sensitive design principles for effective heat mitigation. Optimal performance arises from morphologies that actively manage heat accumulation and facilitate its dissipation, a characteristic exemplified by Block 22’s integrated design. However, even the best-performing Block 22 remains warmer compared to denser central areas, suggesting that urban densification can be a strategy for heat mitigation. Given New Belgrade’s blocks are protected heritage, targeted GI reinforcements remain the only viable approach for improving the outdoor thermal comfort. Full article

The relationship between temperature and mortality is well-documented, yet most existing studies assume this relationship remains static over time. This study investigates whether the temperature-mortality association in Chicago from 1987 to 2000 has changed in shape or location of key features, such as change points. We apply nonparametric regression techniques to estimate the temperature-mortality functions for each year using daily mortality and temperature data from the National Morbidity, Mortality, and Air Pollution Study (NMMAPS) database. A permutation-based test is used to assess whether the shapes of these functions differ across time, while a bootstrap procedure evaluates the consistency of change points. Intensive simulation studies are conducted to evaluate the permutation-based test and bootstrap procedure based on Type I error and power. The proposed tests are compared with F tests in terms of Type I error and power. For the real data set, the analysis finds significant variation in the functional shapes across years, indicating evolving mortality responses to temperature. However, the estimated change points—temperatures associated with peak mortality—remain statistically consistent. These findings suggest that while the population’s overall vulnerability pattern may shift, the temperature threshold linked to maximum mortality has remained stable. This study contributes to understanding the temporal dynamics of climate-sensitive health outcomes and highlights the importance of flexible modeling in public health and climate adaptation planning. Full article

Air–sea interactions play a pivotal role in shaping cyclone development and evolution. In this context, this study investigates the role of ocean optical properties and solar radiation penetration in modulating subsurface heat content and their subsequent influence on the intensity of Mediterranean cyclones. Using a regional coupled ocean–wave–atmosphere model, we conducted sensitivity experiments for Storm Daniel (2023) comparing two solar radiation penetration schemes in the ocean model component: one with a constant light attenuation depth and another with chlorophyll-dependent attenuation based on satellite estimates. Results show that the chlorophyll-driven radiative heating scheme consistently produces warmer sea surface temperatures (SSTs) prior to cyclone onset, leading to stronger cyclones characterized by deeper minimum mean sea-level pressure, intensified convective activity, and increased rainfall. However, post-storm SST cooling is also amplified due to stronger wind stress and vertical mixing, potentially influencing subsequent local atmospheric conditions. Overall, this work demonstrates that ocean bio-optical processes can meaningfully impact Mediterranean cyclone behavior, highlighting the importance of using appropriate underwater light attenuation schemes and ocean color remote sensing data in coupled models. Full article

Cucumbers (Cucumis sativus L.) are highly sensitive to cold, but grafting onto cold-tolerant rootstocks can enhance their low-temperature resilience. This study investigates the physiological and molecular mechanisms by which exogenous vitamin C (Vc) mitigates cold stress in grafted cucumber seedlings. Using cucumber ‘Chiyu 505’ as the scion and pumpkin ‘Chuangfan No.1’ as the rootstock, seedlings were grafted using the whip grafting method. In the third true leaf expansion stage, seedlings were foliar sprayed with Vc at concentrations of 50, 100, 150, and 200 mg L⁻¹. Three days after initial spraying, seedlings were subjected to cold stress (8 °C) for 3 days, with continued spraying. After that, morphological and physiological parameters were assessed. Results showed that 150 mg L⁻¹ Vc treatment was most impactive, significantly reducing the cold damage index while increasing the root-to-shoot ratio, root vitality, chlorophyll content, and activities of antioxidant enzymes (SOD, POD, CAT). Moreover, this treatment enhanced levels of soluble sugars, soluble proteins, and proline compared to control. However, 200 mg L⁻¹ treatment elevated malondialdehyde (MDA) content, indicating potential oxidative stress. For transcriptomic analysis, leaves from the 150 mg L⁻¹ Vc and CK treatments were sampled at 0, 1, 2, and 3 days of cold stress. Differential gene expression revealed that genes associated with photosynthesis (LHCA1), stress signal transduction (MYC2-1, MYC2-2, WRKY22, WRKY2), and antioxidant defense (SOD-1, SOD-2) were initially up-regulated and subsequently down-regulated, as validated by qRT-PCR. Overall, we found that the application of 150 mg L⁻¹ Vc enhanced cold tolerance in grafted cucumber seedlings by modulating gene expression networks related to photosynthesis, stress response, and the antioxidant defense system. This study provides a way for developing Vc biostimulants to enhance cold tolerance in grafted cucumbers, improving sustainable cultivation in low-temperature regions. Full article

The concept of “platinum sensitivity” has long guided prognostic assessment and treatment selection in recurrent ovarian cancer. However, the emergence of targeted agents, such as bevacizumab and poly (ADP-ribose) polymerase inhibitors, has complicated its clinical utility. In contrast, emerging evidence suggests that platinum sensitivity may also be applicable to recurrent endometrial cancer. As in ovarian cancer, a prolonged platinum-free interval (PFI) in recurrent endometrial cancer is associated with an improved efficacy of subsequent platinum-based chemotherapy. The PFI is linearly correlated with the response rate to platinum re-administration, progression-free survival, and overall survival. Patients are typically classified as having platinum-resistant or platinum-sensitive disease based on a PFI cutoff of 6 or 12 months. However, unlike in ovarian cancer—where the duration of response to second-line platinum-based chemotherapy rarely exceeds the prior PFI (~3%)—approximately 30% of patients with recurrent endometrial cancer exhibit a sustained response to platinum rechallenge that extends beyond their preceding PFI. Despite the incorporation of immune checkpoint inhibitors into the treatment landscape of endometrial cancer, the role of platinum sensitivity in clinical decision-making—particularly regarding treatment sequencing and drug selection—remains a critical and unresolved issue. Further research is warranted to elucidate the mechanisms underlying platinum resistance and to guide optimal therapeutic strategies. Full article

The siphon effect between airports has amplified the polarization in passenger throughput, undermining the balanced development and sustainability of airport clusters. The airport siphon effect occurs when one airport attracts a disproportionate share of passengers, concentrating traffic at the expense of others, which affects the overall resilience of the entire airport cluster. To address this issue, this study proposes a siphon index, expands the range of ground transportation options for passengers, and establishes a zero-siphon model to assess the impact of siphoning on the resiliency of airport clusters. Using this framework, four major airport clusters in China were selected as research subjects, with regional aviation accessibility serving as a measure of resilience. The results showed that among the four airport clusters, the siphon effect is most pronounced in the Guangzhou region. To explore the implications of this effect further, three airport disruption scenarios were simulated to assess the resilience of the Pearl River Delta airport cluster. The results indicated that the intensity and timing of disruptive events significantly affect airport cluster resilience, with hub airports being particularly sensitive. This study analyzes the risks associated with excessive route concentration, providing policymakers with critical insights to enhance the sustainability, equity, and resilience of airport clusters. The proposed strategies facilitate coordinated infrastructure development, optimized air–ground intermodal connectivity, and risk mitigation. These measures contribute to building more sustainable and adaptive aviation networks in rapidly urbanizing regions. Full article