Search Results (166)

Robust monitoring of weld pool dynamics is critical for automated arc welding; however, single-modality sensors are frequently constrained by severe optical interference and high-frequency environmental noise. To address these limitations, we propose M2WPR-Net, a novel multimodal framework that synergizes visual and acoustic signals for simultaneous weld width regression and physical quality classification. The architecture employs a dual-stream ResNet50 backbone to process heterogeneous sensory data. Specifically, the visual stream utilizes a Convolutional Block Attention Module (CBAM) to suppress intense arc glare and localize the weld pool. Concurrently, the acoustic stream transforms 1D audio sequences into 2D Gramian Angular Summation Field (GASF) textures, which are subsequently refined by Squeeze-and-Excitation (SE) networks to isolate target frequency channels. A central contribution of this study is a bidirectional cross-modal attention mechanism based on Query–Key–Value (Q-K-V) matrix operations. Overcoming the shortcomings of static feature concatenation, this module dynamically aligns the modalities, enabling acoustic cues to guide visual feature extraction and vice versa, thereby mitigating information bottlenecks. Optimized via a joint multi-task loss function, the proposed M2WPR-Net significantly outperforms existing single-modal and conventional fusion baselines. Experimental results demonstrate that the network achieves a Mean Absolute Error (MAE) of 0.18 mm for width prediction and a 93.5% accuracy in penetration state classification, confirming its resilience and practical applicability in complex industrial welding environments. Full article

Although chitosan (CS)- and essential oil (EO)-based packaging systems have been widely reviewed, a focused synthesis connecting nano-delivery design with interfacial regulation, film-network evolution, release behavior, and preservation performance in real food systems remains lacking. This review addresses that gap by examining CS-based nano-delivery systems for EOs in active food packaging, with an emphasis on how carrier design and multiscale organization govern functional performance. Major delivery strategies, including nanoemulsions, nanoparticles, nanogels, Pickering emulsions, nanofibrous systems, and nanocomposites, are discussed in relation to EO stabilization, dispersion uniformity, and controlled release. Their effects on film microstructure, mechanical and barrier properties, thermal stability, optical behavior, and antimicrobial and antioxidant activities are further evaluated alongside preservation outcomes in fruits, vegetables, dairy products, meat, and aquatic products. Particular attention is given to structure-function relationships across the carrier, interface, and film-network levels, and to the distinction between established active-packaging functions and emerging smart-packaging applications. Current challenges include EO compositional variability, limited cross-study comparability, sensory constraints, migration and regulatory concerns, and insufficiently scalable fabrication routes. Future work should prioritize mechanism-informed interfacial design, standardized evaluation frameworks, food-specific release-preservation correlations, and scalable green manufacturing. Full article

The introduction of regulations restricting the use of microplastics in cosmetics, combined with the growing demand for sustainable cosmetic formulations and the continuing consumer interest in naturally derived ingredients, increases the need to develop alternative functional materials. The aim of this study was to evaluate the effect of plant-derived microparticles obtained from agro-industrial fruit by-products (orange peel) on the properties of cosmetic emulsions as a function of their concentration. Model emulsions containing 0–5% orange peel microparticles were prepared and analyzed in terms of physicochemical properties (viscosity, pH, color, stability), sensory characteristics, antioxidant activity (DPPH), and their impact on skin biophysical and optical parameters. Results showed that increasing microparticle concentration significantly enhanced emulsion viscosity (from 17,000 to 36,000 mPa·s) and antioxidant activity (from 13% to 77% DPPH inhibition). Application studies revealed a 54% increase in skin hydration and a fourfold reduction in transepidermal water loss (from 24 to 6 g/m²/h) for formulations with the highest concentration. However, concentrations containing 3-5% led to reduced emulsion stability. Although higher concentrations (4–5%) provided stronger antioxidant and skin-related effects, the 2% formulation provided the most favorable balance between physical stability, functional performance, sensory acceptance, and formulation appearance. These findings indicate that natural microparticles derived from orange peel can serve as multifunctional, sustainable ingredients in cosmetic emulsions, providing structuring, antioxidant, and skin-barrier-supporting effects. Full article

Background: The vestibular system has traditionally been interpreted within a reflex-based framework, mainly centered on gaze stabilization, vestibulo-ocular reflex pathways, and peripheral vestibular deficits. This model remains essential, but it is insufficient to explain the full spectrum of postural, perceptual, visual-motion, and self-motion complaints observed in contemporary clinical otoneurology. Objective: This conceptual narrative review examines selected representative works by Kathleen E. Cullen as landmarks in a broader transition from reflex physiology to predictive, multimodal, context-dependent, body-centered self-motion control. Methods: This is not a systematic or bibliometric review. Papers were selected because they mark distinct conceptual steps in Cullen’s work: neural encoding of self-motion, peripheral and central coding strategies, multimodal integration, active versus passive self-motion, reafference suppression, body-centered encoding, proprioceptive prediction, vestibular cerebellar internal models, sensory reweighting, and clinical translation. Synthesis: Angelaki and Cullen’s 2008 synthesis and Cullen’s subsequent work demonstrate that vestibular processing is inherently multimodal from the earliest central stages and that neural representations of self-motion depend on behavioral context. Vestibular nuclei, visual-vestibular networks, and vestibular cerebellar circuits integrate labyrinthine signals with optic flow, proprioceptive, oculomotor, motor, cerebellar, cortical, and contextual information. This architecture enables the brain to distinguish expected from unexpected motion, suppress predictable vestibular reafference during voluntary action, compute internal estimates of body motion, adapt to altered sensory reliability, and reweight sensory inputs according to task demands. Conclusions: The clinical relevance of this trajectory is substantial. Patients may show preserved high-acceleration vestibulo-ocular reflex responses while experiencing persistent instability, visually induced dizziness, defective self-motion perception, or abnormal sustained vestibular processing. Such dissociations are not paradoxical when the vestibular system is understood as a predictive, distributed, body-centered control system. Cullen’s long lesson offers a neurophysiological foundation for a modern vestibular grammar in which clinical findings are interpreted across the reflexive, perceptual, postural, visual-vestibular, sustained, and predictive domains. Full article

Lactic acid is a key metabolite in Baijiu fermentation and plays an important role in ester formation and overall flavor development. However, D-lactic acid commonly accumulates in Baijiu and often exceeds L-lactic acid, resulting in low L/D ratios that may negatively affect fermentation performance and sensory quality. Therefore, regulating the optical composition of lactic acid is of significant importance. In this study, an L-lactic acid-enriched wheat bran Qu was developed by inoculating Bacillus cereus B12 and applied in light-flavor Baijiu fermentation. The preparation conditions were optimized using single-factor experiments and orthogonal experimental design. The optimal conditions were an inoculation level of 3%, moisture content of 55%, cultivation temperature of 37 °C, and cultivation time of 60 h, under which the microbial biomass reached 2.02 × 10¹⁰ CFU/g. The L-lactic acid-enriched wheat bran Qu influenced fermentation characteristics, including substrate utilization and physicochemical parameters. Notably, it significantly increased lactic acid production, particularly L-lactic acid, thereby improving the optical composition of lactic acid. Meanwhile, the concentrations of key ester compounds, including ethyl lactate and ethyl acetate, were significantly enhanced (p < 0.05). Microbial community analysis revealed shifts in bacterial composition with enrichment of lactic acid-related genera. These findings demonstrate that L-lactic acid-enriched wheat bran Qu can regulate lactic acid production and promote ester formation, providing a potential strategy for improving flavor quality in light-flavor Baijiu fermentation. Full article

Selective laser melting (SLM) equipment operates as a complex cyber–physical system, wherein strong implicit coupling among internal subsystems presents significant challenges for condition monitoring and fault diagnosis. Existing deep learning methods often suffer from feature submersion when processing multi-source heterogeneous data and lack the capability for system-level topological causal inference. To address these issues, we propose a multisystem coupling modeling and anomaly traceability method based on a decoupled graph attention network (ST-DBGAE). Independent local spatiotemporal feature alignment modules are constructed to map heterogeneous sensory data into a unified latent space. This eliminates dimensional discrepancies while strictly maintaining the feature independence of underlying hardware subsystems, such as optical and gas circuits. A dynamic graph attention mechanism with sparse priors is subsequently introduced to adaptively capture time-varying coupling weights triggered by implicit interactions (e.g., thermal fluids), bypassing the need for predefined rigid physical connections. Furthermore, a dual-branch two-stage decoupled optimization architecture is designed. By blocking the cross-interference of global backpropagation, this architecture outputs a continuous equipment health index (HI) based on reconstruction errors and employs a topological difference matrix inference mechanism to reversely anchor the root-cause nodes responsible for cross-system cascading degradation. Experimental results based on over 310,000 real operational monitoring records from industrial SLM equipment demonstrate that the proposed model achieves a comprehensive diagnostic Macro-F1 score of 96.5% across eight operating states. The single-class detection rates (ACCs) of specific underlying anomalies are significantly improved. This method not only enables high-precision equipment health warnings but also provides a physically interpretable microscopic fault propagation mapping for predictive maintenance. Full article

This study investigates the effect of repeated exposure to optic flow in virtual reality (VR) on postural control in upright standing in older adults. Eighteen participants (>60 years) completed pre/post assessments consisting of quiet standing in a real environment (eyes open/closed), postural responses to simulated forward and backward self-motion in VR, and proprioceptive perturbations induced by bilateral Achilles and tibialis anterior tendon vibration. Intra- (within similar sensory modality) and inter-modal correlations (within different sensory modalities inducing similar directional postural response) were also investigated to provide insight into sensory integration strategies. The intervention consisted of six 100-s VR bouts alternating simulated forward and backward self-motion. Postural outcomes were quantified from force platform recordings as center of pressure (CoP) velocity and excursion. Repeated VR exposure reduced CoP velocity during simulated forward and backward self-motion (p < 0.05). After the intervention, CoP velocity decreased when standing with eyes closed (p < 0.05) but not when eyes were open. Postural response to tendon vibration was not modified by the intervention (p > 0.05). After the intervention, intra-modal correlation for postural responses to optic flow appeared, whereas a pre-existing inter-modal association between Achilles vibration and forward optic flow disappeared. These results indicate that the postural control system remains adaptable in older adults and highlight the potential of VR environments to improve balance in older adults. Full article

As the primary peripheral relay station for vibrissal tactile information, the trigeminal ganglion (TG) features heterogeneous three-dimensional (3D) cytoarchitecture that eludes full characterization using conventional two-dimensional methodologies. A high-resolution 3D imaging and reconstruction pipeline is thus required to unveil TG structural organization and define the spatial framework of target-related sensory neurons. Herein, we established a fluorescence micro-optical sectioning tomography (fMOST)-based workflow for 3D cytoarchitectural mapping of TG anatomy and validated its utility for profiling the distributions of TG neurons innervating vibrissae via single-axon tracing. fMOST imaging coupled with propidium iodide (PI) staining was applied to acquire whole-head anatomical data encompassing the vibrissae and the TG at cellular resolution. Based on clearly resolved cellular morphology and the spatial distribution of neuronal somata, we delineated the soma distribution of TG neurons and revealed a spatially heterogeneous 3D organization pattern, from which we operationally defined two anatomically distinct subdomains: the neuronal soma-rich region (NSRR) and the fiber-rich region (FRR). Furthermore, with retrograde viral/genetic labeling combined with neuronal tracing, TG neurons innervating the C2, D3, and δ vibrissae were observed in both NSRR and FRR, showing partially overlapping yet spatially biased distributions consistent with previous population-level observations of vibrissa-row-dependent topography. Notably, TG neurons innervating the δ vibrissa occupied a comparatively broader spatial extent along the anteroposterior plane in our dataset. Overall, this study facilitates an in-depth mechanistic and anatomical understanding of TG cytoarchitectural organization and underlying functional mechanisms. Full article

Visual discomfort or visual stress is an uncomfortable subjective experience that occurs in response to specific visual stimuli. It affects a large proportion of the population to various degrees, disproportionately impacting those with heightened sensory sensitivities, particularly neurodivergent individuals. We argue that this might stem from a mismatch between the statistical properties of visual stimuli in human-made environments and those in natural environments that the visual system can process efficiently. We discuss the inefficiency with which images with certain spatial, chromatic and temporal characteristics are processed by the visual system and propose a cerebral mechanism to account for the discomfort they induce. The mechanism offers a potential explanation for the large individual differences in susceptibility to discomfort. We highlight two avenues for intervention: (1) environmental modifications aimed at reducing the prevalence of visually stressing stimuli in urban settings, and (2) individual-level strategies, such as personalised optical treatments. Addressing these challenges requires an interdisciplinary effort bridging neuroscience, vision science, interior and urban design and typography to create visually accessible and inclusive environments. Full article

Background and Objectives: This prospective, randomized study aimed to evaluate the effects of different local anesthetic (LA) volume–dose combinations administered during supraclavicular brachial plexus block (SCBPB), a widely used technique in upper extremity surgery. These effects were assessed by analyzing changes in the ratios of optic nerve sheath diameter (ONSD) to eyeball transverse diameter (ETD), obtained by ultrasound (US) and considered indirect measures of intracranial pressure (ICP). Materials and Methods: Sixty four ASA I–II patients aged 18–50 years undergoing upper extremity surgery were randomized into four groups receiving 15 mL (Group A), 20 mL (Group B), 25 mL (Group C), or 30 mL (Group D) of LA (equal volumes of 0.5% bupivacaine and 2% prilocaine). ONSD/ETD ratios were measured bilaterally at baseline, 20, and 60 min. Perfusion index (PI), end-tidal carbon dioxide (EtCO₂), block onset times and block duration were also assessed. Results: Groups C and D showed significant bilateral increases in both ONSDint/ETD and ONSDext/ETD ratios at 20 and 60 min compared with baseline (p < 0.05). Group B demonstrated a significant increase only in the ONSDext/ETD ratio on the block side, whereas Group A showed no significant change. PI increased earlier and more markedly with increasing LA volume–dose. No significant intergroup differences were observed in EtCO₂. In pairwise comparisons, sensory block onset was significantly longer in Group A than in Groups B, C, and D (p < 0.001). Motor block onset was significantly longer in Group A than in Groups C and D, and in Group B than in Group D (p < 0.001). Analgesia duration was significantly shorter in Group A than in Groups B, C, and D, and in Group B than in Groups C and D (p < 0.001). Conclusions: Increasing the LA volume–dose in US-guided SCBPB accelerates sensory and motor block onset and significantly prolongs block duration. A volume-dependent increase in ONSD/ETD ratios was observed on both the blocked and contralateral sides. PI showed an early and marked increase, particularly in high-volume–dose administrations, reflecting block success. Non-invasive EtCO₂ monitoring did not detect significant changes. Full article

Background/Objectives: This study aimed to examine how interpupillary distance (IPD) influences motor and sensory binocular vision functions at distance and near, and to examine associations between different motor and sensory binocular vision functions. Methods: A descriptive cross-sectional study was performed involving 100 random participants of both genders, aged 20 to 38 years. Optically corrected and non-strabismic participants were selected from King Saud University, Riyadh, Saudi Arabia between June 2024 and June 2025. Distance and near IPD were assessed with a pupillometer. Motor binocular functions included horizontal phoria using the von Graefe technique and near point of convergence (NPC). Sensory binocular vision was assessed using crossed and uncrossed TNO and Random-dot E stereopsis tests at near and distance respectively. Statistical analysis was conducted using SPSS version 26 (p ≤ 0.05). Results: IPD and phoria were not significantly associated at distance or near. However, moderate and significant correlations were found between IPD (distance and near) and NPC. Significant correlations were also found between IPD and both crossed and uncrossed stereopsis at distance, but correlations were weak or non-significant at near. A strong correlation was observed between NPC and stereopsis at distance. Conclusions: As interpupillary distance (IPD)increases, near point of convergence (NPC) receded, and stereopsis at distance declined, suggesting that anatomical variation influences binocular vision primarily at distance. Full article

Background/Objectives: Wolfram syndrome type 1 (WS1) is a rare, progressive, multisystem neurodegenerative disorder characterized by diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. As survival has improved, an increasing number of affected women are reaching reproductive age. However, evidence on pregnancy and peripartum management in WS1 remains scarce, and practical guidance is limited. This case report describes the multidisciplinary management of pregnancy and delivery in a woman with genetically confirmed WS1 and highlights key considerations for peripartum care. Case Presentation: A woman with genetically confirmed WS1 and long-standing multisystem involvement, including diabetes mellitus, diabetes insipidus, neurogenic bladder requiring frequent self-catheterization, progressive neurologic manifestations, and severe sensory impairment, achieved pregnancy through assisted reproduction with oocyte donation and was closely monitored by a multidisciplinary team. Due to persistent breech presentation, a planned external cephalic version was performed at 37 + 5 weeks’ gestation with immediate availability for cesarean delivery. After unsuccessful attempts, cesarean delivery was performed under combined spinal–epidural anesthesia. Peripartum management focused on strict glycemic control, careful monitoring of fluid balance and urine output, neuraxial anesthesia with proactive hemodynamic management, precautions related to the cochlear implant, and tailored communication strategies. Postpartum recovery was favorable, although anemia on postoperative day 1 required transfusion of one unit of packed red blood cells and intravenous iron therapy. Discussion and Conclusions: Pregnancy in WS1 represents a high-risk clinical scenario because of the coexistence of endocrine, urologic, and neurologic comorbidities, while published evidence on peripartum management remains limited. This case supports an individualized, multidisciplinary approach to obstetric and anesthetic planning and the use of a practical framework to optimize peripartum management and enhance maternal–fetal safety in this rare condition. Full article

Background/Objectives: Visual motion is a powerful contributor to postural control, yet its influence on modulation of the Ia afferent pathway remains to be confirmed. This study investigated whether optic-flow simulating self-motion modulates the soleus Hoffmann (H) reflex recorded in the soleus during upright stance in immersive virtual reality. Methods: Fourteen healthy adults completed two experimental sessions, each comprising four visual conditions of increasing optic-flow complexity. In one session, participants stood freely on a force platform (free standing) whereas in the other, postural sways were restricted (supported standing). Surface EMG, posterior tibial nerve stimulation, and force-platform recordings were collected. Results: During free standing, optic flow substantially increased postural sway [F(3,13) = 15.7, p < 0.001, η² = 0.55], with higher sway in all optic-flow conditions (~13 mm/s) compared with static viewing (~10 mm/s). In contrast, soleus H-reflex amplitude was not modulated by optic flow [F(3,13) = 0.2, p = 0.57], remaining stable across conditions (~44% M_max). Background EMG and CoP position preceding stimulation were similar across conditions. In supported standing, used to isolate the effect of optic flow independently to postural control, H-reflex amplitude again showed no condition effect [F(3,13) = 0.2, p = 0.86]. Conclusions: These findings indicate that postural perturbation induced by optic flow was not accompanied by a modulation of the Ia afferent-motoneuron transmission of the soleus under the used experimental conditions. The results suggest that postural control under virtual optic flow is mediated predominantly by supraspinal sensory-integration mechanisms, rather than by modulation of the Ia-monosynaptic reflex pathway. Full article

The aim of this study was to investigate the substitution of egg yolk in mayonnaise-type sauces with alternative protein components and to optimize the hydrocolloid composition for improved stability and rheological properties. Mustard powder (1%), soybean flour (1%), casein (2%), and cream powder (1%) blends were employed as emulsifiers. The influence of the ratio of potato starch, carboxymethylcellulose (CMC), pectin, and xanthan gum (0–1% each) on the properties of low-fat mayonnaise formulations with 30% oil content was examined. Sedimentation and thermal stability tests revealed high resistance of all samples (98–99%) after 24 h of storage. Optical microscopy confirmed a homogeneous structure with individual dispersed particles of 100–150 μm corresponding to plant protein inclusions. The particle size distribution D [3,4] exhibited a bimodal profile with peaks at 0.1–1 μm and 2–8 μm, indicating efficient homogenization. Storage experiments demonstrated an increase in particle size by 1.4–1.6 times and a decrease in viscosity, likely due to flocculation and aggregation of polysaccharide clusters into larger agglomerates. Among the tested formulations, the sample containing 0.3% CMC, 0.3% xanthan gum, and 0.4% pectin showed the most favorable physicochemical and sensory properties, highlighting the synergistic effect of hydrocolloid blends in stabilizing reduced-fat mayonnaise-type emulsions. Full article

Emerging evidence highlights the critical role of corneal nerves in the pathophysiology of dry eye disease (DED) and other related ocular surface disorders (OSDs). These conditions increasingly demonstrate neuropathic and neurotrophic components, wherein alterations in corneal nerve morphology and function contribute to symptomatology and disease progression. Recent advances in imaging and diagnostic modalities have enabled detailed, in vivo evaluation of corneal nerve architecture and sensory function, offering novel insights into underlying mechanisms and therapeutic responses. This review comprehensively examines current and emerging technologies for corneal nerve assessment, both structural and functional. The structural methods include in vivo confocal microscopy (IVCM), optical coherence tomography (OCT)-based nerve imaging (e.g., micro-OCT), and emerging technologies like multiphoton microscopy. The functional methods of corneal nerve assessment include advanced esthesiometers, quantitative sensory testing (QST), and functional magnetic resonance imaging (fMRI). The emerging technologies also include AI-driven analytical platforms that can be applied to both structural and functional methods. These various nerve assessment modalities can aid in delineating DED subtypes, selecting targeted treatments, monitoring nerve regeneration, and predicting treatment outcomes. By integrating structural and functional assessments, these technologies are reshaping the diagnosis, phenotyping, and management of DED and other related OSDs, paving the way for personalized therapeutic approaches. Full article