Search Results (1,904)

Background/Objectives: Tablet development requires simultaneous optimization of multiple quality attributes under limited experimental budgets, yet formulation–property relationships are highly nonlinear in mixture systems. To support pre-formulation decision-making prior to extensive tablet prototyping, this study proposes an AI framework that organizes formulation and process data together with raw-material property records into a reusable database, and enriches conventional composition/process features with physically motivated mixture descriptors derived from raw-material properties and formulation/process settings. Methods: Mixture-level scalar descriptors are constructed by composition-weighted aggregation of material properties, and particle size distribution (PSD) is incorporated via a compact set of summary statistics computed from composition-weighted mixture PSDs. Three feature sets are compared: (i) Materials + Processes (MP), (ii) MP with scalar Descriptors (MPD), and (iii) MPD with PSD summaries (MPDD). Five target properties are modeled: hardness, disintegration time, flow function, cohesion, and thickness. We train and evaluate Random Forest, Extra Trees Regressor, Lasso, Partial Least Squares, Support Vector Regression, and a multi-branch neural network that processes the three feature blocks separately and concatenates them for prediction. For interpolation assessment, repeated Train/Dev/Test splitting (5:3:2) across multiple random seeds is used, and the effect of feature augmentation is quantified by paired RMSE improvements with bootstrap confidence intervals and paired Wilcoxon signed-rank tests. To assess robustness under practical formulation updates, rolling-origin time-series splits are employed and Applicability Domain indicators are computed to characterize out-of-distribution coverage. Results: Across interpolation evaluations, mixture-descriptor augmentation (MPD/MPDD) improves hardness and disintegration time in most settings, whereas gains for flow function are smaller and cohesion/thickness show mixed effects under limited sample sizes. Conclusions: Under extrapolation-oriented evaluation, the descriptors can improve hardness but may degrade disintegration-time prediction under covariate shift, emphasizing the need for careful descriptor selection and dimensionality control when deploying pre-formulation predictors. Full article

Accurate modeling of learners’ evolving cognitive states is essential for intelligent educational systems, yet many existing knowledge tracing and graph-based approaches rely on static structures or purely sequential representations that inadequately capture dynamic structural changes in learning processes. This study proposes a Learner Cognitive Graph (LCG) framework that integrates dynamic heterogeneous graph modeling, structured behavioral data acquisition, and reinforcement learning-based intervention optimization. A Dynamic Cognition Graph (DCG) is formally defined as a sequence of temporally evolving graph snapshots representing interactions among learners, knowledge concepts, and exercises. A reverse Turing test-based agent with structured prompting is introduced to collect reasoning-oriented behavioral evidence, improving data reliability for cognitive modeling. Temporal message passing, multi-scale memory updating, and self-supervised learning objectives are employed to construct dynamic cognitive representations. Personalized intervention is formulated as a Markov decision process to optimize long-term learning outcomes. Experiments conducted on real-world and simulated educational datasets demonstrate improved knowledge mastery prediction accuracy, cognitive state transition modeling, and intervention efficiency compared with representative baselines. The proposed framework provides a systematic and scalable approach for dynamic cognitive modeling and adaptive educational support. Full article

Project-based organizations (PBOs) face persistent challenges in managing workload fluctuations that influence performance, competitiveness, and resource sustainability. Although previous research has explored bidding strategies and project inflows and outflows, few studies have systematically modeled workload-capacity dynamics or assessed policy responses to manage them effectively. To address this gap, this study develops a system dynamics (SD) model that integrates both pre-award and post-award project phases with internal and external organizational processes. Data for model development were drawn from the literature, industry reports, and expert interviews, resulting in the identification of 28 variables organized into subsystems covering demand, capacity planning, work execution, competitiveness, and financial performance. The model was validated through dimensional and structural tests, expert review, and further examined using social network analysis (SNA) and sensitivity analysis. The SNA results identified workload, production rate, and organizational capacity as the most influential variables. Sensitivity analysis conducted through Monte Carlo experiments, employing screening, regression, and ANOVA (analysis of variance) methods, revealed that capacity adjustment flexibility, minimum capacity, and demand level are critical factors influencing organizational stability. The validated model was then applied to evaluate policy alternatives under two distinct market conditions. Findings indicate that in lowest-price environments, a competitive, market-share-oriented policy enhances utilization and responsiveness, whereas in average-price markets, a stable capacity policy yields more sustainable outcomes. These results demonstrate how project-based organizations can strategically adjust bidding and capacity policies to stabilize workload dynamics and improve long-term operational resilience under different market conditions. The study contributes theoretically by extending the application of SD modeling to workload-capacity management in PBOs and contributes practically by offering a decision-support tool that helps managers assess capacity strategies, reduce risks, and align organizational policies with long-term sustainability objectives. Full article

In water injection development of tight oil reservoirs (TORs), the complex fracture network formed by hydraulic fracturing and water injection induction is the key factor determining the development effectiveness. Accurate inversion of water injection-induced fracture parameters holds significant importance for enhancing reservoir development outcomes. This paper innovatively proposes a parameter inversion framework that integrates the Embedded Discrete Fracture Model (EDFM) with intelligent optimization algorithms. EDFM efficiently characterizes complex unstructured fracture systems while maintaining mass conservation between the matrix and fractures; intelligent optimization algorithms automatically invert parameters such as fracture half-length, orientation, and conductivity. First, a three-dimensional geological model of the TOR is constructed, utilizing EDFM to handle the impact of fractures on the seepage field. Based on considerations of fracture geometry, conductivity, and stress sensitivity, a coupled fluid dynamics model for fractures and matrix is developed. Subsequently, an objective function is built based on water injection production dynamic data, and the Projection-Iterative-Methods-based Optimizer (PIMO) algorithm is employed to achieve efficient inversion of fracture parameters. Taking a TOR in the Ordos Basin as an example for verification, through synthetic model validation, this method significantly improves the accuracy and efficiency of history matching, with inversion results reliably guiding numerical simulation predictions. The results demonstrate that this method can effectively enhance the precision of fracture parameter identification, offering clear advantages in inversion speed and accuracy over traditional trial-and-error approaches. This study provides new insights for modeling induced fractures in TORs and optimizing water injection development strategies. Full article

In this study, a generalized and advanced form of the near soft set theory (NST) framework is proposed for information aggregation (IA) processes. The primary motivation of the study is to address the lack of similarity-based uncertainty modeling in the literature by integrating the parametric structure of soft sets with the similarity-oriented structure of nearness approximation spaces. Within this framework, the AND-product and OR-product operations are introduced as the main methodological tools, and their algebraic structures are analyzed in detail. It is mathematically demonstrated that these operations satisfy fundamental properties such as idempotency, absorption, distributivity, and De Morgan identities. The principal original contribution of the study is the development of a novel Uni–Int-based decision-making mechanism that enables the systematic distinction between strong and acceptable alternatives. In addition, the boundary frequency indicator ($b_r$), which quantitatively evaluates the reliability of objects under perceptual uncertainty and is introduced for the first time in the literature, is proposed. The applicability of the proposed model is demonstrated through a real-estate selection problem, and a sensitivity analysis is conducted to reveal the determining effect of the nearness parameter r on decision granularity. The obtained findings indicate that the proposed NST framework provides a more flexible, more discriminative, and structurally robust decision-support model than classical approaches, particularly for similarity-based IA problems. Full article

Grid-forming (GFM) battery energy storage system (BESS) inverters are becoming a cornerstone of resilient microgrids, where severe voltage sags and abrupt operating shifts can challenge both voltage regulation and controller stability. Finite-set model predictive control (FS-MPC) offers fast transient response and multi-objective coordination, yet conventional designs rely on static cost-function weights that are typically tuned offline and may become suboptimal under disturbance-driven regime changes. This paper proposes a forecast-guided KAN-adaptive FS-MPC framework that (i) formulates the inner-loop predictive control in the stationary αβ frame, thereby avoiding PLL dependency and mitigating loss-of-lock risk under extreme sags, and (ii) introduces an Operating Stress Index (OSI) that fuses load forecasts with reserve-margin or percent-operating-reserve signals to quantify grid vulnerability and trigger resilience-oriented control adaptation. A lightweight Kolmogorov–Arnold Network (KAN), parameterized by learnable B-spline edge functions, is embedded as an online weight governor to update key FS-MPC weighting factors in real time, dynamically balancing voltage tracking and switching effort. Experimental validation under high-frequency microgrid scenarios shows that, under a 50% symmetrical voltage sag, the proposed controller reduces the worst-case voltage deviation from 0.45 p.u. to 0.16 p.u. (64.4%) and shortens the recovery time from 35 ms to 8 ms (77.1%) compared with static-weight FS-MPC. In the islanding-like transition case, the proposed method restores the PCC voltage within 18 ms, whereas the static baseline fails to recover within 100 ms. Moreover, the deployed KAN governor requires only 6.2 μs per inference on a 200 MHz DSP, supporting real-time embedded implementation. These results demonstrate that forecast-guided adaptive weighting improves transient resilience and power quality while maintaining DSP-feasible computational complexity. Full article

Underwater sonar object detection is challenging because targets are often small, boundaries are blurred, background clutter is strong, and labeled sonar data are limited. To address these issues, we propose T2C-DETR, a detector built on RT-DETR with three task-oriented improvements: (i) a Transformer–Convolution dual-channel backbone (TCDCNet) for complementary global-context and local-detail modeling, (ii) a Noise Filtering Module (NFM) inserted before neck fusion to suppress noise-dominated activations, and (iii) a stage-wise transfer-learning strategy tailored to small sonar datasets. We evaluate the method under three pre-training sources (COCO 2017, DOTA, and an infrared dataset) and then fine-tune on a self-built sonar dataset. Experimental results show that T2C-DETR achieves AP50 of 97.8%, 98.2%, and 98.5% at 72–73 FPS, consistently outperforming the RT-DETR baseline, YOLOv5-Imp, and MLFFNet in the accuracy–speed trade-off. These results indicate that combining global–local representation learning with targeted noise suppression is effective for practical real-time sonar detection. Full article

Non-organic (muscle) weakness (NOw) is proposed as a distinct pathological entity characterized by maladaptive neuroplasticity (learning) affecting motor control. Functional deficits are most directly revealed through the manual muscle testing (MMT) break test, which uniquely exposes a muscle’s ability to adapt to increasing external load, potentially serving as an index of motor control integrity. We advance the “muscle-motor-movement PTSD” (mPTSD) model in which learning during pain or stress (trauma) yields chronic avoidance (inhibition) of the associated muscles. In a second stage, compensatory synergies develop, overriding attempts at hypertrophy-oriented training. This non-systematic, integrative review synthesizes clinical reports, learning theories, motor control and pain literature, and objective tests of force and movement over time during MMT. Predictive processing and reinforcement learning offer complementary accounts of how hyper-precise priors and passive avoidance may maintain NOw beyond functional recovery. Unexplained muscle weakness is found in non-specific musculoskeletal disorders and functional motor disorder (functional weakness), but may also contribute to other conditions, such as kinesiophobia. Effective alternative treatments for NOw may act by updating or erasing maladaptive motor learning by disrupting memory reconsolidation, allowing immediate restoration of function. Analogous to psychoneuroimmunology’s role in immune function, we propose “psychoneurokinesiology”, the study of how maladaptive learning affects movement. Full article

Ensuring the structural integrity and operational safety of oil and gas pipelines is a critical challenge due to their extensive geographical coverage and exposure to environmental and anthropogenic risks. Traditional inspection approaches including ground patrols and manned aerial surveys are labor-intensive, costly, and often lack real-time responsiveness. While unmanned aerial vehicles (UAVs) enable flexible and high-resolution monitoring, their practical deployment requires lightweight, robust detection models capable of real-time inference on embedded edge hardware under heterogeneous environmental conditions. This paper presents an end-to-end, edge-deployable UAV inspection framework for simultaneous detection of above-ground pipelines and visually observable anomaly/leak indicators using the official Ultralytics YOLOv26n object detector. A curated dataset of 6127 UAV images acquired across desert, semi-urban, and industrial environments was annotated with two classes (Pipeline and Anomaly/Leak) and partitioned into training 87.5%, validation 8.3%, and testing 4.2% subsets. The detector was fine-tuned from COCO-pretrained weights for 300 epochs at 600 × 600 resolution and evaluated using COCO-style metrics. On the held-out test set, the proposed model achieved 92.4% mAP@0.5 and 75.0% mAP@0.5:0.95, with 89.7% precision, 90.2% recall, and 89.9% F1-score at the selected operating threshold. Optimized TensorRT deployment on an NVIDIA Jetson Xavier NX sustained real-time inference at 18 FPS, demonstrating suitability for onboard UAV processing. Rather than proposing a new detector architecture, the study contributes a domain-specific annotated UAV dataset, deployment-oriented benchmarking, and an end-to-end edge inference workflow for corridor-scale monitoring. The proposed framework can help reduce environmental contamination risk and improve personnel safety during pipeline inspection. Full article

Remote sensing has become a cornerstone of modern agricultural monitoring, addressing the dual challenges of increasing production while ensuring environmental sustainability. Based on a conceptual framework developed over the past decade, key application areas include yield estimation, phenology, stress assessment (e.g., drought), crop mapping, and land-use change detection. In Central Europe, regionally specific conditions such as fragmented land ownership, small and irregular plots, and high climate variability shape these applications. Annual field crops, such as cereals, oilseeds, maize, and forage crops dominate production and represent the primary focus of monitoring efforts. Optical data from Sentinel-2 are effective for mapping crop types and analyzing phenology, especially when dense time series are available. However, persistent cloud cover during critical growth phases limits the effectiveness of optical approaches, prompting the integration of radar data from Sentinel-1. Multi-sensor strategies increase the robustness of classification and temporal continuity, supporting monitoring under adverse conditions. Reliable reference data from systems such as the Land Parcel Identification System enables parcel-level validation and facilitates object-oriented analyses in line with management needs. Future developments will increasingly rely on advanced time-series analysis, machine learning, and the integration of agrometeorological and crop model data. As climate change intensifies drought frequency and yield variability, remote sensing will play a pivotal role in enabling near-real-time monitoring and decision support within the evolving landscape of digital agriculture ecosystems. The aim of this review article is to provide an overview of crop monitoring in the Central European region over approximately the past fifteen years, emphasizing trends in subsequent technological and procedural developments. Full article

Scientific publishing is currently constrained by an unstructured narrative bottleneck paradigm, which increasingly diverges from the scale, complexity, and computational nature of modern research. Despite rapid advancements in data generation and analysis, scientific knowledge is predominantly disseminated as static narrative artifacts, thereby limiting reproducibility, machine accessibility, and cumulative integration. This study explores how scientific communication can be restructured to facilitate scalable validation and reliable knowledge accumulation. We propose the Object-Oriented Scientific Information paradigm, wherein scientific contributions are represented as executable, machine-interpretable objects that integrate structured data, reproducible methodologies, and formally encoded semantic claims. To operationalize this paradigm, we delineate the architecture of an Autonomous Knowledge Engine, a modular neuro-symbolic system that combines domain-specialized Mixture-of-Experts routing, formal verification of claims, and an information-theoretic filter based on marginal information gain. This architecture enables continuous validation, redundancy control, and the integration of scientific contributions within an active knowledge graph. The analysis demonstrates that Object-Oriented Scientific Information (OOSI) and Autonomous Knowledge Engine (AKE) fundamentally differ from existing document-based, executable, and semantic publishing models by shifting epistemic control from narrative evaluation to computational verification. We conclude that transitioning toward a computable scientific record is essential for sustaining reliable and self-correcting science in the context of accelerating knowledge production. Full article

To reduce charging time and improve operational efficiency at integrated energy stations (IESs) for electric vehicles (EVs), this paper develops a sustainability-oriented collaborative optimization model by coupling vehicle routing behavior with charging decision-making. Firstly, a dynamic road network model is established to simulate vehicle arrivals at IESs from different network nodes. Then, considering grid peak–valley electricity prices, station electricity procurement costs and EV charging demand, a dynamic pricing strategy for IESs is proposed to guide EVs to charge at off-peak hours so as to realize peak shaving and valley filling for the power grid. Meanwhile, the NSGA-III algorithm is improved through the introduction of Good Point Set initialization and an adaptive crossover mechanism, and the Good Point Set initialization and Adaptive Crossover NSGA-III (GPS-AC-NSGA-III) algorithm is proposed to solve the scheduling optimization problem. Finally, the CRITIC-based TOPSIS method is employed to identify the optimal compromise solution from the Pareto-optimal set. Case studies further prove the effectiveness of the proposed multi-objective collaborative optimization model for EVs and IESs. Compared with scenarios without dynamic Dijkstra-based navigation and dynamic pricing, the IES daily revenue increased by 39.83%, pollutant emissions decreased by 0.4%, and the peak-to-valley load difference ratio was reduced by 4.94%. The results indicate that dynamic Dijkstra-based vehicle routing improves travel efficiency, while the proposed dynamic pricing strategy enhances station profitability and smooths grid load fluctuations. Overall, the proposed framework contributes to sustainable transportation and energy systems by reducing pollutant emissions, improving energy efficiency, and enhancing the operational stability of integrated energy infrastructure, thereby supporting the transition toward low-carbon and sustainable urban energy systems. Full article

Background: Brain-derived neurotrophic factor (BDNF) is central to synaptic plasticity and neurodevelopment. Toxic metal exposure is linked to oxidative stress and neuroinflammation, yet its effects on BDNF signaling remain unclear. Objectives: To systematically synthesize evidence from human and experimental studies on the association between environmental or occupational metal exposure and BDNF alterations, and to highlight research gaps with an emphasis on hexavalent chromium (Cr(VI)). Methods: PubMed, Scopus, and ScienceDirect were searched following PRISMA guidelines. Eligible studies included human observational research and animal models reporting quantitative associations between metal exposure (biomarkers/environmental measures) and BDNF outcomes (protein or gene expression). Data were extracted on exposure assessment, BDNF measurement, and neurobehavioral outcomes. Study quality was assessed using NOS (human studies) and SciRAP (experimental studies). Results: Nineteen studies were included. Across metals such as Pb, Hg, Cd, As, Mn, and mixtures, exposure was associated with altered BDNF levels in blood or brain tissue, often alongside oxidative stress markers, inflammatory changes, and cognitive or behavioral impairment in animal models. Most human studies reported decreased circulating BDNF with higher exposure, while experimental evidence suggested context-dependent regulation across exposure windows and brain regions. Conclusions: The available evidence supports a biologically plausible link between metal exposure and BDNF dysregulation. No eligible studies evaluated BDNF in relation to Cr(VI), indicating a major research gap. Future studies should integrate neurotrophic biomarkers with exposome-oriented designs to clarify chromium-related neurotoxicity and support Adverse Outcome Pathway (AOP)-informed frameworks. Full article

This study develops a multi-objective optimization framework for sustainable container truck dispatching in port logistics, addressing the limited joint consideration of environmental compliance, worker-sensitive assignment, and operational efficiency in traditional dispatching practice. The problem is formulated as a constrained assignment-and-scheduling model under time-window, compliance, capacity, and service requirements. To balance optimality and real-time responsiveness, a dual-path solution strategy is proposed, combining a mixed-integer linear programming (MILP) model for small-scale instances with a Priority-Based Constructive Heuristic with Conflict Resolution (PBCH-CR) for medium-to-large-scale scenarios. Computational experiments on scenario-based synthetic instances calibrated to empirical port-operation distributions show that PBCH-CR maintains 100% environmental compliance for assigned orders, improves familiarity-oriented matching relative to the FCFS baseline, and sustains strong emergency-response performance within sub-minute computation times. Sensitivity analysis further shows that improving urgency-oriented performance entails a reduction in freight-revenue-oriented performance. Overall, the framework provides a practical approach to balancing environmental compliance, operational efficiency, and worker-sensitive dispatching, with relevance to Sustainable Development Goals 11 and 13 and to SDG 8-related objectives. Full article

Autonomous navigation is essential for orchard transportation robots to support automated operations and precision orchard management. However, in trellis orchards, dense vegetation and complex canopy structures often degrade the stability of GNSS-based navigation in in-row environments. To address this issue, this study proposes a GNSS–vision integrated navigation framework for orchard transportation robots. The performance of GNSS-based navigation in out-of-row environments and vision-based navigation in in-row environments was experimentally evaluated under representative orchard operating conditions. In out-of-row areas, the robot employs GNSS-based path planning and trajectory tracking to achieve reliable navigation in relatively open, lightly occluded environments. During in-row navigation, a deep learning-based real-time object detection approach is used to detect tree trunks and trellis supporting structures. By integrating corner-point selection with temporal RANSAC-based line fitting, a stable orchard row structure is constructed to generate robust navigation references. The visual perception module serves as the front-end sensing component of the navigation system and is designed to be independent of specific object detection architectures, allowing flexible integration with different real-time detection models. Field experiments were conducted under various orchard layouts and growth stages. The average lateral deviation of GNSS-based navigation in out-of-row scenarios ranged from 0.093 to 0.221 m, while the average heading deviation of in-row visual navigation was approximately 5.23° at a robot speed of 0.6 m/s. These results indicate that the proposed perception and navigation methods can maintain stable navigation performance within their respective applicable scenarios in trellis orchard environments. The experimental findings provide a practical and engineering-oriented basis for future research on automatic navigation mode switching and system-level integration of orchard transportation robots. Full article