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Background: Malnutrition is a significant clinical problem in patients with cancer, occurring not only during hospitalization but also throughout the recovery phase. It brings severe health and economic consequences, affecting patients on both physical and psychological levels. The American Society for Parenteral and Enteral Nutrition (ASPEN) and the European Society for Clinical Nutrition and Metabolism (ESPEN) emphasize the critical importance of early detection of nutritional disorders and timely intervention in oncology populations. The aim of this study was to determine the prevalence of malnutrition and factors associated with malnutrition among hospitalized Polish oncology patients and to draw attention to the need for early nutritional assessment in patients with cancer so as to ensure appropriate nutritional care. Methods: A multicenter cross-sectional study was conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines among adult patients diagnosed with cancer and undergoing oncological treatment. Data collection involved a structured survey questionnaire, anthropometric measurements, and validated screening tools: Mini Nutritional Assessment (MNA), Nutritional Risk Screening Score 2002 (NRS 2002), and Subjective Global Assessment (SGA). Results: The study group comprised 560 patients with a mean age of 55 ± 13.95 years, including 59% women and 41% men. The mean duration of illness was 3.37 years. Advanced-stage cancer was present in 43% of participants, and 66% were undergoing chemotherapy. The mean Body Mass Index (BMI) for the study group was 23.14 kg/m², with a mean MNA score of 16.23 points and a mean NRS 2002 score of 2.39 points. Based on Subjective Global Assessment, moderate malnutrition was identified in 45% of patients, whereas severe malnutrition was confirmed in 27% of the study population. Conclusions: The prevalence of malnutrition among oncology patients is high. Early screening and regular monitoring are essential for the prompt identification of patients at risk, enabling the implementation of appropriate nutritional therapy and the improvement of clinical outcomes. Full article

Driven by the escalating worldwide consumption of animal-sourced commodities, the livestock industry faces intensified constraints regarding its ecological consequences, encompassing large-scale deforestation, elevated greenhouse gas emissions, progressive soil deterioration, and the suboptimal management of hydrological resources. In response to these challenges, the concept of sustainable livestock husbandry integrates production practices with environmental management strategies designed to conserve biodiversity, optimize resource use, and reduce emissions. The objective of this review is to emphasize the significance of sustainable cervid farming as an integral element of contemporary food supply chains, comprehensively addressing its environmental, production, and nutritional dimensions. A comprehensive assessment of current scholarly articles from Scopus, Web of Science, and Google Scholar was performed to explore topics concerning eco-conscious livestock practices, non-conventional farming models, organic rearing, animal well-being, and the evolution of deer breeding. Particular attention was paid to the role of permanent grasslands in venison production, soil protection, carbon sequestration, and biodiversity preservation. The nutritional value of red deer and fallow deer meat and its significance in sustainable food systems are also outlined. As indicated by the analysis of available research findings, extensive cervid farming based on the use of permanent grasslands and local feed resources can reduce environmental pressures through support of landscape conservation, preservation of ecosystem functions, and efficient utilization of biomass that is inedible for humans. Venison is shown to be a valuable source of high-quality protein, minerals, and essential fatty acids, which meets growing consumer demands for high-quality food. The literature review has confirmed that properly managed cervid farming can be an important element of sustainable food production systems combining production goals with environmental protection and animal welfare. It also emphasizes the need for further research into the environmental, economic, and social aspects of this branch of animal production. Full article

The multifunctionality of Moringa oleifera is widely recognized; however, its application in small ruminant production remains limited. This study aimed to analyze research trends, scientific structures, and knowledge gaps related to the use of Moringa oleifera in sheep and goat production through a bibliometric approach. A total of 203 articles published between 2002 and 2025 were retrieved from the Scopus and Web of Science databases and analyzed using VOSviewer (version 1.6.20). Data mining identified contributions from 41 countries, 804 authors, 241 institutional/organization affiliations and 109 journals. Publication output increased markedly after 2020, with India, Egypt, and Mexico leading scientific production. Keyword co-occurrence analysis revealed animal nutrition and productive performance as the main research themes, with recent expansion toward reproductive biology and enteric methane mitigation. A. E. Kholif and G. A. Gouda were the most cited authors. Bibliographic coupling network analysis of journals identified four thematic clusters, indicating disciplinary expansion beyond traditional animal science. Important gaps remain regarding the economic impacts of Moringa oleifera use and the standardization of preparation methods, including plant parts, extraction procedures, solvents, and dosages. Full article

With the intention of investigating in further depth the horticultural biodiversity resulting from the selection and conservation effort carried out by farmers (custodians) who are dedicated to growing traditional products, we focused on six local landraces of Brassica rapa L. subsp. sylvestris (L.) Janch.; we conducted analyses addressing the presence of glucosinolates (GLSs), phenolic compounds and the antioxidant capacity of extracts of B. rapa landraces belonging to three groups with different growth phase behavior from planting to inflorescence appearance in the Salento area (Puglia or Apulia region, Italy). The studies focused on three local landraces known by Salento farmers as cima di rapa cinquantina (two separate accessions, 50SC and 50SD), cima di rapa sessantina (accessions 60SC and 60SD) and rapacaula (accessions rcSD and rcGA). We revealed the presence of eleven different glucosinolates and three main flavonoids, such as kaempferol, quercetin and isorhamnetin derivatives. The distribution and content of glucosinolates and flavonoids varied widely among the different landraces. Glucobrassicanapin was the predominant compound in all landraces, followed by gluconapin, except for 60SC, where the main GLS was the indolic glucobrassicin. Moreover, 50SC, 50SD and 60SC are characterized by the highest flavonoid content and the highest antioxidant capacity. The findings provide the basis for the characterization of B. rapa subsp. sylvestris L. local landraces as a useful source of valuable metabolites for human health, as well as for identifying one landrace with higher nutritional value as a starting point for accession conservation and economic development. Full article

Carob has traditionally been used as a nutritious alternative to cocoa. The present study evaluated the physicochemical, microbiological, nutritional, sensorial, phenolic, and antioxidant profile, along with the bioaccessibility of phenolics and antioxidants, of a developed carob-based spreadable product in comparison with two commercially available similar chocolate–hazelnut spreads popular in Greece. Moreover, the implemented food safety management system and the economic impact of the new product were also considered. The carob-based product was slightly more acidic (pH 5.3) and had an increased water activity (a_w = 0.67) when compared to the commercial chocolate spreads. Consumer acceptability for the developed product was almost 80%, and it had a shelf-life of over six months. In terms of nutritional value, the product is suitable for vegans with no added animal protein and preservatives, while it is also low in saturated fat, high in fiber, and very low in sodium. Comparatively, the carob-based product exhibited higher total phenolic (TPC) but lower total flavonoid (TFC) contents and increased DPPH activity than the other two cocoa-based spreads (p < 0.05). Predicted bioaccessibility in the newly developed product was 67% for TPC (p ≥ 0.05) and 10% for total antioxidant capacity (TAC; p < 0.05). Market analysis indicates that there is a considerable margin of profit for the developed product against competition. Conclusively, this research demonstrates that carob-based food products with functional properties can constitute a suitable, promising alternative to conventional cocoa-based similar products. Full article

Several global challenges are converging: rising organic solid waste generation, growing food demand, and increasingly unfavorable conditions for food production, including more frequent and severe droughts, water scarcity, and limited agricultural land for expansion. Bioconverting organic waste into alternative protein sources has emerged as a promising strategy to address waste management and feed production challenges simultaneously. This study presents a comprehensive systematic literature review on protein production through the bioconversion of residual biomass using the black soldier fly (BSF, Hermetia illucens). The BSF is a highly voracious organism during its larval stage and can substantially reduce organic waste volumes while converting them into biomass rich in proteins and lipids with high nutritional value for livestock and aquaculture feed formulations. The review examines Waste-to-Protein systems from three perspectives: technical, economic, and environmental. The technical perspective focuses on production system operations and substrate properties. The economic perspective addresses profitability indicators, capital and operating costs, economies of scale, and the economic performance of incorporating insect-derived protein into animal production systems. From an environmental perspective, Life Cycle Assessment (LCA) is the predominant method for evaluating WtP-BSF systems. Among the systems assessed using LCA, 63% rely on crop-derived substrates for larval feeding. These substrates have intrinsic commercial value, and together with the environmental burdens associated with energy consumption during BSFL rearing, they may constrain the overall sustainability and profitability of WtP-BSF systems. By evaluating factors such as feed dosage, larval density, actual organic waste, and eco-efficiency metrics for livestock feed, opportunities for a circular economy could be developed in developing countries, helping to decrease dependence on landfills. Full article

The Northwest Xizang White Cashmere goat has a high global reputation for good goat cashmere germplasm characteristics, and its cashmere industry is the economic pillar of the herdsmen in the northwest plateau of Xizang. Cashmere is produced by the secondary hair follicles of the skin, and the key period of hair follicle development is from birth to 3 months old. This study aimed to explore how early compound nutritional intervention affects lamb growth performance and secondary hair follicle development. We assessed skin follicle density and performed skin transcriptomic and multi-omics analyses to clarify this regulatory effect. The trial was performed at the Northwest Xizang White Cashmere Goat Breeding Farm, Ritu County, Ngari region, Xizang. Thirty newborn single lambs of comparable birth status were randomly divided into control and early compound nutritional intervention groups (n = 15 per group). The results showed that early compound nutritional intervention significantly increased the secondary hair follicle density, total hair follicle density, and secondary/primary hair follicle (S/P) value of lambs (p < 0.05). However, there was no significant difference in the average cashmere fineness between the two groups (p > 0.05). The transcriptome, proteome, and metabolomics analyses of the skin revealed candidate genes related to hair follicle development and the regulation of cashmere fineness: keratin structural genes (KRT10, KRT18, KRT26), cell proliferation and adhesion-related regulatory genes (ITGB2, CSF1R, AKT1), and extracellular matrix coding genes (COL6A1, COL6A2, COL6A6). Moreover, the results revealed that key proteins related to hair follicle development include RBP4, KAP13-3, KRTAP3-1, KRTAP27-1, DKK3, ITGB2, and DUSP23. The differentially expressed metabolites, 15-Deoxy-delta12,14-Prostaglandin J2 and Thromboxane B2 (TXB2), modulate prostaglandin-associated pathways; altered pathway activity subsequently regulates the expression of hair follicle functional genes and key proteins, which may in turn indirectly regulate hair follicle growth and development, thereby affecting hair follicle density and, by extension, cashmere production performance. Therefore, early compound nutritional intervention of Northwest Xizang White Cashmere goats promotes the growth and development of secondary hair follicles. The identified candidate genes and key proteins involved in secondary hair follicle development provide a reference for exploring the mechanism of hair follicle development. Full article

Open-field burning of agricultural residues is a persistent environmental challenge that contributes to greenhouse gas emissions, air pollution, and the loss of valuable biomass resources. This study developed sustainable mushroom cultivation substrates by replacing 50% of conventional sawdust with locally available agricultural residues, including corn stalks, rice straw, sugarcane leaves, and leaf litter, to reduce production costs, enhance mushroom productivity, and promote circular bioeconomy practices. The physicochemical properties, mycelial growth, contamination, yield performance, nutritional composition, economic feasibility, and environmental benefits of the alternative substrates were evaluated using Lentinus sajor-caju and Pleurotus species. Among the tested formulations, corn stalk-based substrates exhibited the most favorable characteristics, with improved nitrogen availability and a more balanced C/N ratio, resulting in faster colonization, lower contamination, quicker fruiting body formation period, and superior biological efficiency. The corn stalk formulation achieved the highest productivity across species, including biological efficiencies of 61.99% for L. sajor-caju, 102.79% for P. cornucopiae, 99.40% for P. ostreatus, and 101.96% for P. pulmonarius. In addition, alternative substrates maintained or enhanced mushroom nutritional quality, with high protein (18.22–31.37%), dietary fiber (up to 30.58%), and low-fat contents (1.11–1.95%). Economic analysis demonstrated that a 50:50 sawdust-biomass substitution strategy substantially reduced substrate costs, achieving approximately 30% savings at industrial production scales. Overall, this study demonstrates that converting agricultural residues into high-value mushroom substrates provides an effective strategy to improve production efficiency, reduce costs, and advance sustainable mushroom cultivation systems. Full article

The analysis of genetic gain and changes in economic traits among modern and older cultivars is important to estimate breeding progress, evaluate the effectiveness of selection methods, identify optimised and neglected attributes, detect trade-offs, and inform strategies in crop improvement programs. This meta-analysis analysed global genetic gain and changes in seed yield, yield-related traits, and seed compositional attributes in soybean (Glycine max [L.] Merr.). A meta-database comprising 272 genetic gain data points recorded from 29 studies and 2555 mean performances captured from 34 research papers was compiled from research reporting cultivars released globally between the 1920s and 2010s. The mean values extracted from these studies were subjected to the R-Software analysis of variance (ANOVA) to reveal the effects of year of cultivar release and production region on the studied agronomic and compositional attributes. Boxplots were constructed to visualise data distribution and variability, and Pearson correlation and principal component analysis (PCA) were performed to examine inter-relationships among the measured traits with year of cultivar release and production region. Significant differences (p < 0.001) in mean performance were found among decades of cultivar release for seed yield (SY), number of seeds per pod (NSPod), days to flowering (DTF), days to maturity (DTM), and total biomass (TB). Cultivars released in the 2000s attained the highest mean SY of 3737.62 kg ha⁻¹, compared to 2156.08 kg ha⁻¹ observed for varieties released in the 1960s. Annual mean increases for SY ranged from 1.75 to 47 kg ha⁻¹year⁻¹, driven primarily by improvements in number of seeds per plant (NSP), NSPod, plant height (PH), DTF, TB, and hundred seed weight (HSW). Conversely, seed protein content (SPC) declined across most breeding programs, while seed oil content (SOC) showed only modest improvement, and no consistent genetic gains were documented for micronutrient traits, including iron (Fe), zinc (Zn), calcium (Ca), or phytic acid (PA) content. Phytic acid, a potent chelator of essential minerals and a known inhibitor of protein digestibility in monogastric species, represents a critical but largely untracked compositional target in global soybean breeding. The absence of PA as a systematically monitored trait constitutes a significant gap in the literature, with direct implications for the nutritional quality of improved cultivars. Future breeding programs should adopt an integrated approach that simultaneously targets high SY, enhanced micronutrient bioavailability, and reduced antinutritional factor concentrations to advance both agricultural productivity and global food and nutrition security. Full article

Food is lost and wasted at different points in the food supply chain, causing serious environmental, social and economic implications. School lunches are a significant source of food waste at the consumption stage. This study, undertaken in the framework of the Interreg Central Europe project ‘foodCIRCUS’, investigates food preparation, consumption, and waste generation in six educational institutions (three primary schools and three kindergartens) in Wrocław, Poland. Monitoring was done during five consecutive days in each institution (October–December 2024), covering food produced and eaten as well as unserved food, serving leftovers, and plate waste for the main lunch components (soup, protein, starch, and vegetables). The main results give an overall amount of food waste of 236 g/meal planned, with a wastage level of 45%. This is higher than values reported in the literature and higher than the commonly cited global estimate of approximately 30% across the entire food supply chain. Most of the wastage occurred as plate waste (27% of the total food prepared), whereas unserved food constitutes 18%. Primary schools show higher levels of unserved food due to variability in meal uptake, whereas kindergartens show higher plate waste. Vegetables and certain starch-based dishes (groats) have the highest wastage levels. It can be concluded that both operational and behavioral factors cause food waste in school canteens. The national nutrition guidelines lead to a consistent overproduction of food in kindergartens and primary schools, both with their own kitchens and served by catering companies. Reduction strategies should focus on behavioral approaches such as nudging or awareness-raising and operational optimization (e.g., improved forecasting and portion control), as well as redistribution approaches for surplus. The national nutrition guidelines should be interpreted and implemented less strictly. Each pupil should be given the chance to eat portions according to the amounts based on the guidelines, but this does not mean that these amounts have to be prepared for all the pupils potentially attending lunch (as for many it is not their only nutrition source). Full article

The rapid expansion of global aquaculture and increasing demand for sustainable protein sources have intensified the search for alternatives to conventional fish meal. Wolffia globosa, the smallest and fastest-growing flowering plant, has emerged as a promising yet underutilized aquatic resource with significant potential in aquaculture nutrition and sustainable food systems. Despite growing interest in aquatic plant-based proteins, comprehensive evaluation of W. globosa across nutrition, cultivation, and application systems remains limited. This review synthesizes current knowledge on its biology, nutritional composition, functional properties, and application potential in aquaculture and circular bioeconomy systems. W. globosa exhibits rapid vegetative propagation, high biomass productivity, and minimal resource requirements, enabling efficient cultivation in nutrient-rich environments. It contains high-quality protein (20–48% dry weight), essential amino acids, polyunsaturated fatty acids, dietary fiber, vitamins, minerals, and diverse bioactive compounds with antioxidant and immunomodulatory properties. Feeding studies demonstrate its potential to enhance growth performance, feed efficiency, and physiological health in aquatic species. Additionally, its capacity to absorb nitrogen and phosphorus supports nutrient recycling and water quality improvement in integrated aquaculture systems. However, variability in nutrient composition, limited large-scale cultivation data, insufficient long-term feeding trials, and uncertain economic feasibility at industrial scale remain key challenges for its commercial adoption. Overall, W. globosa represents a promising but still developing biomass resource with strong potential to reduce dependence on fish meal while supporting environmentally efficient aquaculture and future food systems. Future research should focus on optimizing cultivation practices, developing efficient processing technologies, and validating long-term feeding performance to facilitate its large-scale adoption. Full article

To verify the growth-promoting effects of Bacillus amyloliquefaciens on silage maize (Zea mays L.), optimize its application dosage, and elucidate rhizosphere microecological responses, this study executed field experiments in both conventional and saline-alkali soils. We comprehensively assessed how varying biofertilizer dosages (0, 300, and 600 kg ha⁻¹) influenced crop phenotypes, soil physical and chemical attributes, and rhizosphere microbial communities. Results demonstrated that applying B. amyloliquefaciens substantially enhanced biomass and crude protein accumulation in silage maize, without compromising its ideal carbohydrate profile and fermentation characteristics. The observed growth stimulation was likely linked to efficient mobilization of native soil nutrients. Following biofertilizer application, significant surges in available potassium, available phosphorus, and inorganic nitrogen were recorded at both locations, coupled with successful pH buffering in the saline-alkali plots. Microbial analysis indicated a notable expansion of the copiotrophic Proteobacteria phylum, with the bio-inoculant displaying dose-dependent shifts. Specifically, Xanthobacteraceae was heavily recruited in standard agricultural soils to hasten nutrient mineralization, while stress-tolerant bacterial groups like Nitrosomonadaceae were stimulated under saline-alkali conditions. Furthermore, comprehensive phenotypic and nutritional evaluations demonstrated that, among the tested doses, an application rate of 300 kg ha⁻¹ effectively optimizes crop performance. Higher doses do not yield proportional biological benefits, likely due to the carrying capacity limits of the rhizosphere microecology. In summary, B. amyloliquefaciens can support high-yield and high-quality silage maize production by activating soil nutrients and remodeling the core rhizosphere microbiome in a habitat-specific manner. Among the tested doses, 300 kg ha⁻¹ showed the best performance, but further studies with lower doses and longer durations are needed to determine the true optimal application rate and to assess its economic and environmental sustainability. Full article

Poultry nutrition has evolved beyond simply formulating diets to meet nutrient requirements, with greater attention given to feed efficiency, animal health, environmental challenges, and the quality of poultry products. This Special Issue brings together 11 studies covering a range of topics, including alternative ingredients, functional dietary additives, feed processing, heat-stress mitigation, intestinal microbiota, and poultry product quality. The studies investigated insect meals, Bombyx mori, Camelina sativa, and Spirulina platensis, in addition to phytogenic compounds, selenium, fermented feeds, and enzyme-based approaches. The results show that these nutritional strategies can influence growth performance, nutrient utilization, immune and antioxidant responses, as well as meat and egg characteristics. At the same time, several factors may limit their application in commercial poultry production. These include differences in the composition of alternative ingredients, variation in responses under different experimental conditions, and the relatively small number of studies carried out under commercial production settings. Future studies should place greater emphasis on understanding their mechanisms of action, establishing appropriate inclusion levels, and assessing potential interactions among different strategies. It will also be important to consider the economic feasibility and environmental consequences of their use. Such information will help translate experimental findings into practical and more consistent nutritional strategies for poultry. Full article

This paper explores the potential for promoting Ethiopian teff flour through the European Union’s Geographical Indications (GI) framework. After outlining the evolution of GI regulations in the international trade context and the EU’s role in quality policy for agri-food products, the paper assesses the value of teff as a high-potential product. Originated and domesticated around Axum, teff is a staple crop in Ethiopia, both nutritionally and socio-economically, cultivated by a multitude of smallholder farmers. However, access to European markets is hindered by insufficient enforcement of food safety standards, lack of quality control, and inconsistent labelling practices. Recognition as a GI—specifically as a Protected Geographical Indication (PGI)—could enhance the visibility, traceability, and legal protection of Ethiopia’s teff. The paper also highlights challenges in advocating for the development of a detailed product specification aligned with EU regulations. Integrating teff production into the GI system may strengthen rural economies, preserve traditional knowledge, and increase the international profile of a product with significant nutritional and economic potential. Full article

Background/Objectives: Children and adolescents living with HIV (ALHIV) are among the most vulnerable groups affected by HIV and AIDS. Their vulnerability exposes them to several challenges, such as HIV-related stigma and/or interrupted academic activities due to health-related complications. Since they are still minors who cannot independently make decisions regarding their own lives, most of the challenges extend to their caregivers, who sometimes provide care and support under difficult psychological, social, and economic conditions. This study aimed to explore the lived experiences and challenges of primary caregivers caring for ALHIV in Gauteng Province of South Africa. Methods: A qualitative exploratory design with phenomenological orientation was adopted. Eight primary caregivers of ALHIV were purposively sampled and interviewed using individual face-to-face semi-structured interviews. Data was analysed thematically according to the eight steps of Tesch’s qualitative analysis framework. Since it involved human participants, this study was subjected to ethical clearance by the Research Ethics Committee of the University of South Africa, which imposed conditions for upholding ethical principles such as informed consent and confidentiality. Results: Primary caregivers encounter challenges such as regular monitoring of ALHIV who are always sick, treatment adherence monitoring, behavioural management, financial strain, stigma and discrimination, lack of proper nutrition and managing adolescents’ academic difficulties. These challenges require support from multidisciplinary team members which include nurses because they play a crucial role in supporting treatment adherence among ALHIV and in strengthening the capacity of primary caregivers to provide effective treatment support. Conclusions: It is essential to adopt an integrated approach to psychosocial, as well as financial support interventions targeting primary caregivers. Full article