Search Results (1,785)

The retrofit of existing residential buildings plays a critical role in reducing energy consumption and carbon emissions in the building sector. However, previous retrofit evaluations often fail to account for the age-related thermal and lighting requirements of residents in aging residential buildings, thereby overlooking the substantial behavioral heterogeneity that shapes retrofit effectiveness. This study evaluates the comprehensive performance of different building envelope retrofit strategies, considering occupants’ thermal and visual comfort, from the perspectives of energy efficiency, economic feasibility, and environmental sustainability. First, age-specific differences in occupancy patterns, thermal preferences, and lighting requirements between elderly and non-elderly comparison group occupants were systematically extracted from the literature. Then, a typical high-rise residential building was modeled in EnergyPlus to serve as the reference building, within which the differentiated occupant behavior models were implemented, and the pre-retrofit condition was defined as the baseline scenario. Next, six commonly applied exterior wall insulation materials and different glass configurations and window frames were parameterized and evaluated under varying insulation thicknesses and remaining building service life scenarios. Finally, the energy-saving performance, economic benefits, and carbon reduction potential of envelope retrofit measures were quantitatively assessed across three primary functional zones (bedroom, living room, and study), using area-normalized indicators. The results indicate that, in the retrofit of existing residential buildings, bedrooms and study rooms exhibit greater retrofit benefits than living rooms, primarily due to longer occupancy durations and higher heating demand. In terms of retrofit strategies, exterior wall insulation consistently outperforms window retrofitting in energy-saving potential, with energy-saving rates of approximately 3.2–4.3% depending on functional zone, material type, and insulation thickness. Among the evaluated materials, vitrified microbead insulation performs best overall in terms of energy, economic, and carbon benefits at 40–60 mm thickness. These findings support occupant-informed, low-carbon retrofit decision-making for existing residential buildings. Full article

This study proposes a non-invasive, simplified muscle force estimation model (NSMFEM) designed for elderly individuals and stroke patients under slow walking conditions. The model estimates lower limb muscle forces dynamically using only kinematic parameters—with real-time muscle fiber length as the key variable—thus avoiding the limitations of traditional surface electromyography (sEMG)-based approaches such as environmental interference, signal noise, and difficulty in obtaining deep muscle sEMG. A personalized Digital Twin Musculoskeletal Model (DTMSM) was constructed by scaling a reference kinematic model and calibrating muscle origin/insertion markers based on individual anthropometry. Muscle architecture indices were derived from a multiple regression model with publicly available anatomical data. Twelve elderly subjects (eight healthy ESND and four post-stroke ESP) were evaluated at varying walking speeds. Results at slow speeds (X-slow and slow) show strong Pearson correlations between NSMFEM predictions and reference data for the majority of nine representative lower limb muscles (e.g., TFL, Iliacus, Pectineus, Tib_Ant, Soleus); passive forces of TFL, Iliacus, and Vas_Int also correlate strongly. As speed rises, correlations for some muscles (e.g., Vas_Int, Tib_Post) decline, reflecting the growing influence of segmental acceleration and muscle activation—factors omitted in the model. For stroke patient gait (ESP), Spearman analysis indicates maintained strong correlations for affected side muscles Glut_Max1, TFL, Pectineus, and Soleus, supporting the model’s utility in stroke rehabilitation assessment. Overall, NSMFEM offers a practical, sEMG free method for non-invasive dynamic muscle force estimation in slow walking elderly and post-stroke populations, aiding functional assessment and personalized rehabilitation planning. Future efforts will aim to incorporate muscle activation corrections to extend the model to faster walking speeds. Full article

Background: Obstructive sleep apnea (OSA) is a highly prevalent and heterogeneous sleep disorder. This study aimed to investigate age- and sex-specific phenotypes of OSA in a large clinical cohort, with special emphasis on the effects of aging and menopause on disease severity, hypoxemic component, symptom expression, comorbidities, and screening tool performance. Methods: A retrospective cross-sectional analysis was conducted on 3736 patients with confirmed OSA referred to a tertiary sleep clinic in Greece between 2013 and 2023. Participants were stratified by age and sex. Women were further classified as pre- and post-menopausal using age as a proxy. Clinical characteristics, comorbidities, questionnaire data and polysomnographic indices were analyzed using parametric and non-parametric statistical methods. Results: OSA severity peaked in middle age and remained high in older adults, while nocturnal hypoxemia and cardiometabolic comorbidities worsened with age. Women presented at an older age and with higher body mass index but lower Apnea Hypopnea Index (AHI) compared to men, yet experienced significantly longer hypoxemia and more severe insomnia. Women over 45 years exhibited a markedly more severe and hypoxic phenotype and substantially higher rates of comorbidities. Screening tool performance varied across subgroups: STOP-BANG was the most consistent, while symptom-based tools performed poorly in young women and elderly patients. Conclusions: OSA is a dynamic dependent disorder with distinct phenotypes across the lifespan. Current screening strategies fail to adequately capture these variations, particularly in women and older adults. A personalized, sex- and age-specific approach to OSA diagnosis and management is essential to reduce underdiagnosis and improve outcomes. Full article

Background: Radiotherapy (RT) combined with androgen deprivation therapy (ADT) is a standard treatment for non-metastatic high-risk (HR) prostate cancer (PC). However, the benefit of elective nodal irradiation (ENI) in clinically node-negative (cN0) patients, although suggested, remains controversial, particularly in the elderly. We report the outcomes of elderly HR PC patients treated with prostate-only RT (PORT) and ADT in a “real-word” setting. Methods: Between 2016 and 2022, 43 consecutive elderly patients (median age 76 years) with HR- or very HR-PC according to NCCN criteria version 1.2026 (cN0, cT3-cT4 and/or ISUP Grade Group 4–5 and/or PSA serum levels at diagnosis ≥ 20 ng/mL) were treated at our institution. All patients were staged with abdominal MRI or CT and bone scan; nineteen patients (44.2%) also underwent 68Ga-PSMA-11 or 18F-fluorocholine PET/CT. All patients received PORT (predominantly moderate hypofractionation, 67.5–70 Gy in 25–28 fractions) and ADT (median duration 24 months). To ensure consistency, all oncological endpoints—Biochemical Failure-Free Survival (BFFS; Phoenix criteria), Disease-Free Survival (DFS), Metastasis-Free Survival (MFS), Prostate Cancer-Specific Survival (PCSS), and Overall Survival (OS)—were calculated from a unified time-zero (initiation of first oncological treatment). DFS was defined as a composite endpoint including biochemical failure, radiological recurrence, or initiation of salvage therapy. Results: at a median follow-up of 60 months, no patient reached the Phoenix threshold, resulting in a 100% 5- and 7-year BFFS. However, 4 patients (9.3%) experienced radiological recurrence detected via PET/CT before reaching the nadir + 2 threshold, yielding an estimated 5-year and 7-year DFS of 94.7% and 71.8%, respectively. The 5- and 7-year MFS was of 97.6% and 88.7%, respectively. Seven deaths occurred, all non-PC related, resulting in a 5-year OS of 86.7% and a Prostate Cancer-Specific Survival of 100%. Gastrointestinal toxicity was notably low (no acute or late G3-G4 events). Conclusions: Our findings suggest that PORT, when combined with long-term ADT and modern staging, provides excellent disease control and a favorable safety profile in elderly HR PC patients. Given the high rate of competing mortality in this population, treatment de-escalation via PORT appears to be a clinically reasonable strategy. These results are hypothesis-generating and warrant validation in prospective randomized trials. Full article

Background: Non-small cell lung cancer (NSCLC) constitutes about 80–85% of lung cancers, and ~60–70% of NSCLC patients are diagnosed at an advanced stage of the disease. Concurrent chemoradiotherapy (cCRT) followed by consolidation durvalumab has become the standard of care for unresectable stage III NSCLC, following the phase III PACIFIC trial, which demonstrated significantly improved progression-free survival (PFS) and overall survival (OS) with durvalumab. Methods: We conducted a single-center retrospective study with unresectable stage III NSCLC patients who received cCRT between January 2021 and December 2025 at the Białystok Oncology Center (Poland). Patients with an ECOG performance status of 0–1 and no disease progression (PD) after cCRT were treated with durvalumab consolidation up to 12 months or until PD or unacceptable toxicity. The clinical outcomes and treatment tolerance were analyzed. Results: Out of 94 cCRT-treated patients (pts), 78 received durvalumab consolidation therapy. The median age of the pts was 66.5 years; 64.1% pts were >65 years old. Squamous carcinoma was the predominant histology (56.4%). The median time from cCRT completion to durvalumab initiation was 45 days (range: 15–85). A majority (57.7%) of patients completed the full 12 months of durvalumab. With a median follow-up of 40 months, the median PFS was ~1224 days (40.2 months). At 3 years, PFS was 52.8%. There were no significant differences in PFS by age (<65 vs. ≥65 years), HR:0.65, clinical stage (IIIA vs. IIIB/IIIC) HR:1.01, histology (squamous vs. non-squamous carcinoma), HR:0.76; sex HR:0.6, ECOG 0 vs. 1 HR:0.82; or initiation of durvalumab ≤42 vs. >42 days after cCRT, HR:0.62 (p > 0.05 for all). The sole factor significantly affecting PFS was smoking status: ever-smokers had a longer PFS than never-smokers (median ~46 months vs. ~21 months, HR:2.11, p = 0.04). Durvalumab consolidation was generally well tolerated. Grade 3–4 adverse events (mainly pneumonitis and esophagitis) leading to permanent durvalumab discontinuation occurred in 7 patients (9%), almost all over 65 years old. Conclusions: Real-world data from our single-center study confirm that consolidation durvalumab therapy after cCRT provides substantial clinical benefit in unresectable stage III NSCLC, even in older patients. The PFS and safety outcomes in our cohort, which had a higher proportion of elderly and locally advanced cases, were comparable with those reported in clinical trials (PACIFIC) and observational studies (PACIFIC-R), underscoring the effectiveness and tolerability of this approach in routine practice. We acknowledge the limitations of the retrospective design and sample size, but our findings support the use of cCRT followed by durvalumab in eligible stage III NSCLC patients and highlight the need for further research on optimizing outcomes (e.g., the impact of smoking and other biomarkers). Full article

Background/Objectives: Syncope remains a common problem in the elderly, adversely affecting quality of life, morbidity and mortality. Diagnosis is challenging due to the atypical presentation, multifactorial aetiology, overlap with non-syncoptic falls and increased prevalence of cardiac disease. This study aims to investigate the impact of cardiac syncope in this high-risk population. Methods: A retrospective single-centre observational cohort study, including 171 patients ≥65 years old with syncope of unknown origin or other falls, was conducted. Different diagnostic tests and strategies were utilised during the investigational process, based on clinical judgement and the latest guidelines. Patients were classified either in the ‘high risk’ (‘cardiac’) or ‘low-risk’ (‘autonomic’) pathway. Results: Mean age was 76.4 ± 6.6 years (range: 65–92 years old) and the mean follow-up period was 40.5 months. Our study population was characterised by a high incidence of comorbidities and underlying heart disease, and polypharmacy. One third of the patients did not report prodromals, 81.9% had no recognisable trigger and 43.3% had various 12-lead ECG abnormalities. Overall, 67.8% of the patients were stratified in the ‘cardiac pathway’. Eventually, a final diagnosis was established in 126 patients (73.7%). The cause was cardiac syncope in 56.4%, reflex syncope in 26.2%, orthostatic hypotension in 7.9% and non-syncopal falls in 9.5%. An ILR was implanted in 90.1% with a diagnostic yield of 43%. ECG-based diagnosis occurred in 53.2% whereas time to diagnosis was 4.8 ± 3.3 months. Conclusions: Cardiac disease, mostly arrythmias, represent a common and possibly underestimated cause of unexplained syncope in the elderly. A structured approach including a targeted use of ILRs improves investigational process. Full article

Falls pose severe risks to vulnerable populations, particularly the elderly and individuals with adverse neurological conditions, necessitating reliable and non-obstructive detection systems. While previous multi-modal approaches utilizing video and audio have demonstrated strong performance, they face significant limitations regarding sensitivity to environmental noise. This paper presents a robust, video-only fall detection framework that eliminates reliance on acoustic data to enhance universality. We conduct a comprehensive comparative analysis of five optical flow (OF) algorithms—Horn–Schunck, Lucas–Kanade (LK), LK-Derivative of Gaussian, Farneback, and the spectral method SOFIA—to determine the range of applicability of each technique for capturing fall dynamics. Beyond detection accuracy, we investigate the computational efficiency of each configuration. This optimized, privacy-centric pipeline offers a scalable solution for continuous monitoring in home and clinical settings, addressing the critical need for immediate intervention following high-impact falls. Full article

Sudden cardiac death (SCD) is a major global health issue, defined as sudden natural death presumed to be of cardiac cause. While in the elderly SCD is commonly associated with coronary artery disease, in the younger population it is linked to inherited cardiomyopathies or channelopathies, even though SCD can remain unexplained even after a comprehensive autopsy in a substantial proportion of cases. In this context, genetic testing has gained importance, supported by the widespread availability of techniques such as next-generation and whole-exome/genome sequencing and their reduced costs. This state-of-the-art review summarizes the genetic bases of sudden cardiac death among cardiomyopathies, channelopathies and in sudden unexplained death presumed to be of arrhythmic cause. Among the structural causes, inherited cardiomyopathies such as hypertrophic, dilated, non-dilated left ventricular, arrhythmogenic right ventricular and restrictive ones represent major substrates for malignant ventricular arrhythmias mostly arising from variants in sarcomeric or desmosomal genes. Channelopathies (long or short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia) are caused by variants in genes encoding cardiac ion channels and/or regulatory proteins, which equally predispose to high risk of life-threatening ventricular arrhythmias. In sudden arrhythmic death syndrome, with a structurally normal heart, post-mortem genetic testing (molecular autopsy) can uncover an underlying inherited condition. However, variants of uncertain significance are detected in more than half of the cases, underscoring the need for a multidisciplinary approach. Genetic testing also plays a key role in cascade screening of first-degree relatives. While monogenic variants drive risk in inherited cardiac disorders, emerging evidence suggests that polygenic contributions may modulate SCD susceptibility, highlighting future roles for polygenic risk scores in risk stratification. Full article

Background: Changes in body composition, such as decreased muscle mass and increased adipose tissue, are significant in older adults, impacting health, functional capacity, and increasing the risk of metabolic diseases, functional decline, and frailty. Bioelectrical Impedance Analysis (BIA) is a non-invasive tool for assessing body composition, including fat-free mass (FFM), skeletal muscle mass (SMM), and fluid distribution (e.g., ECW/TBW ratio). Complementing BIA, the Mini Nutritional Assessment (MNA) serves as a validated tool for identifying malnutrition risk in the elderly. This study aimed to understand the correlation between BIA-derived parameters, MNA scores and clinical outcomes. Methods: This cross-sectional study involved 195 older adults (mean age 72.8 ± 5.4 years), divided into two groups based on body composition profiles determined by cluster analysis. Data collected included demographics, comprehensive BIA parameters (BMI, fat mass, FFM, SMM, ECW/TBW, phase angle), MNA scores, self-assessed health, chronic disease prevalence, frailty index (TFI), and functional limitations (EQ-5D). Statistical analyses included descriptive statistics, t-tests/ANOVA, chi-square tests, Pearson’s/Spearman’s correlations, point-biserial correlations, regression analyses, and ROC curve analysis to compare groups, explore variable relationships, and assess predictive abilities for malnutrition risk. Results: The first group had significantly higher BMI, AFM (AFM), FFM, and SMM, but a lower ECW/TBW ratio compared to Group 2 (N = 115), which was predominantly female and had higher frailty scores. MNA scores showed significant positive correlations with FFM (rho = 0.165, p = 0.021) and SMM (rho = 0.182, p = 0.011), and a negative correlation with ECW/TBW (rho = −0.188, p = 0.008). Higher adiposity (BMI, fat mass) correlated positively with arterial hypertension and obesity. Lower FFM and SMM were negatively correlated with gastroesophageal reflux disease. Skeletal muscle mass (AUC = 0.634, cut-off ≤ 17.3 kg) and ECW/TBW ratio (AUC = 0.626, cut-off ≥ 49.7%) showed modest discriminatory capacity to identify malnutrition risk. Individuals at risk of malnutrition reported greater functional limitations and lower self-assessed health. Numerous BIA parameters, including segmental muscle mass, total body water, phase angle, and impedance values, significantly correlated with MNA scores. Conclusions: The study highlights the importance of body composition analysis, particularly BIA, in correlation with MNA, for assessing nutritional status, functional limitations, and chronic disease associations in older adults. Integrating BIA and MNA into geriatric assessments provides a complementary profile of nutritional and functional vulnerability. Full article

Background/Objectives: Nasal reconstruction after non-melanoma skin cancer excision remains challenging due to the need to restore both nasal form and function while ensuring oncologic safety. Beyond surgical success, patient-reported outcomes are increasingly recognized as essential components of postoperative evaluation. The aim of this study was to retrospectively assess oncologic, surgical, and patient-reported outcomes in a real-world cohort of patients undergoing nasal reconstruction following skin cancer excision. Methods: A retrospective cohort study was conducted on 60 patients treated at the University Hospital “G. Martino” (Messina, Italy) between 2019 and 2022. Reconstructive techniques included direct closure, full-thickness skin grafts, local or regional flaps. Oncologic outcomes and postoperative complications were recorded during routine follow-up. Patient-reported outcomes were evaluated using a semi-structured PROM-derived questionnaire adapted from the FACE-Q Skin Cancer Module, NOSE, and SCaFF domains. Internal consistency of the questionnaire was assessed using Cronbach’s alpha. Results: Basal cell carcinoma was the most frequent diagnosis (55%), and the nasal ala, dorsum, and tip were the most commonly involved subunits. Local flaps were performed in 42% of cases. No histologically confirmed recurrences were observed in the flap-reconstructed subgroup during the available follow-up, whereas recurrences were observed in patients managed with non-flap reconstructive approaches. Postoperative complications were uncommon; however, one fatal infectious event occurred in a high-risk patient undergoing complex reconstruction for recurrent disease. The PROM-derived questionnaire demonstrated good internal consistency (Cronbach’s α = 0.82). Functional symptoms were rare, with 93% of patients reporting no snoring or nasal obstruction and 97% reporting no nasal voice alteration. Aesthetic satisfaction was rated as satisfactory or very satisfactory by 63% of patients, and social relationships were not affected in 85%. Patient-perceived recurrence risk (38%) exceeded histologically confirmed recurrence (15%). Conclusions: In this elderly real-world cohort, flap-based nasal reconstruction was associated with generally favorable patient-centered outcomes and low complication rates. The discrepancy between patient-perceived and confirmed recurrence highlights the role of oncologic anxiety. Prospective studies using fully validated PROMs are warranted to support standardized outcome comparison and guide clinical decision-making. Full article

Mild behavioral impairment (MBI) constitutes a late-life transition state that is associated with an increased risk of cognitive impairment and dementia. Herein, we cross-sectionally describe the MBI construct and its relationship with cognitive status in Mexican-Mestizos (MM) older adults. Participants were classified according to their cognitive and behavioral statuses using tests administered to older adults and their informants. APOE_rs429358/rs7412 variants were genotyped by real-time PCR. Multivariate correlation and Principal Components Analysis (PCA) were used in statistical analysis. A total of 246 participants were included, 56.1% were classified as individuals with NC, 13.0% had subjective cognitive decline, and 30.9% had mild cognitive impairment. A total of 37% (91/246) of participants from all over the cognitive spectrum met the MBI criteria; among this group, APOEε4 homozygosity was associated with two subdomains of the MBI. Subjective cognitive complaint, symptoms of depression, and cognitive decline reported by the informant were associated with an increased risk for MBI (ORs in the range of 4.7–15.89). The first three components of PCA explained 68.0% of the variance of the dataset, including the MBI-checklist total score as a main contributor. Well-known risk factors for dementia also correlated with this PCA. MBI could be a potential marker for cognitive decline in non-demented MM elderly people; however, observed associations should be confirmed in future longitudinal studies. Full article

Rural revitalization has emerged as a core agenda in the global pursuit of sustainable development, with its success fundamentally hinging on enhancing the resilience of rural households to withstand shocks and restore their livelihoods. In contrast to mainstream research that primarily examines whether Medical Financial Assistance (MFA) reduces medical burden, this paper focuses on MFA as ex-post cash compensation and investigates whether and how it affects the sustainable livelihood recovery of low-income rural households following health shocks, thereby providing empirical evidence for understanding the foundational role of health security in rural revitalization. A quasi-natural experiment is constructed by leveraging the institutional feature that MFA eligibility is activated by exogenous health shocks. Using two-wave balanced panel data (2021–2022) from a nationally designated deep poverty-stricken county in Hebei Province, China, the Propensity Score Matching–Difference-in-Differences (PSM-DID) method and mediation models are employed for causal identification and mechanism testing. The findings indicate that (1) MFA significantly promotes household income recovery. It enables recipient households to recover per capita net income by an average of approximately 13.2% (p < 0.01), demonstrating a protective recovery effect, and simultaneously recovers per capita non-farm labor income by an average of approximately 13.8% (p < 0.05), revealing a developmental recovery effect. The latter is partially mediated by the non-farm labor participation rate (mediation ratio 51.7%, Sobel Z = 2.10). This finding validates the “time release effect,” demonstrating that MFA stimulates endogenous dynamics by restoring health capital and releasing labor previously constrained by family care responsibilities. It thereby extends the application of health capital theory from the individual to the household level. (2) Mechanism analysis shows that the protective recovery effect is fully mediated by the amount of MFA received (mediation ratio 326.7%, Sobel Z = 12.85), providing empirical evidence for precautionary saving theory in the context of targeted social assistance and revealing the potential productive attributes of the social safety net. (3) Heterogeneity analysis reveals clear group targeting and shock thresholds. The protective effect is concentrated among elderly households, while the developmental effect is primarily evident in middle-aged households. Both recovery effects manifest significantly only for households experiencing major disease shocks, confirming the theoretical expectation of “conditional effectiveness,” namely that policy effects are systematically moderated by household life-cycle characteristics and the severity of health shocks. This study demonstrates that MFA serves both as a safety net and an empowerment tool, but its effectiveness is highly contingent upon household characteristics and shock severity. By uncovering the foundational mechanisms through which health security contributes to rural household resilience, this study provides empirical evidence from China for building sustainable poverty prevention systems in the global process of rural revitalization. Full article

Background: The elderly remain a population group at risk of developing severe forms of SARS-CoV-2 infection. Age and the prevalence of comorbidities are important risk factors for mortality related to COVID-19. Severity scores enhance medical practice, proving to be useful tools in predicting mortality. Objectives: The purpose of this study is to assess the predictive accuracy of the CURB-65, Pneumonia Severity Index, MuLBSTA, COVID-GRAM and PADUA scores in patients over 70 years of age diagnosed with SARS-CoV-2 infection. Methods: We performed a retrospective study between June 2023 and December 2024, analyzing demographic data, vaccination status, comorbidities, discharge status, and computed the five scores. Results: A total of 173 patients aged over 70 years old were included in the study. Among them, 56.06% were male with a median age of 79.72 ± 6.55. Many patients had at least one comorbidity (93.06), among which hypertension (67.63%), neurological pathology (41.61%), diabetes mellitus (28.90%) and obesity (28.32%). Tumor pathology was associated with an increased risk of death. Admission to the intensive care unit and mechanical ventilation were also risk factors for increased mortality in the study population. The area under the ROC curve (AUC) of the scores (in descending order) was: 0.914 for PADUA, 0.854 for MuLBSTA, 0.831 for PSI, 0.719 for CURB-65 and 0.703 for COVID-GRAM. Conclusions: All the severity scores used were significantly higher in the non-survivor group, with PSI, MuLBSTA, and PADUA scores revealing acceptable prediction ability for mortality. Full article

Sarcopenia is a complex condition marked by reductions in muscle strength, mass, and overall physical performance, which has significant consequences for functional autonomy and metabolic health in elderly women. This study aimed to examine the correlations between lower limb strength, functional capabilities, and metabolic indicators in community-dwelling older women categorized according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. A total of thirty-eight women aged ≥ 60 years underwent assessments, including anthropometric, hemodynamic, and metabolic evaluations, along with functional tests such as handgrip strength, chair-rise test, gait speed, Timed Up-and-Go, and maximal isometric hip extension strength (MIHE). The criteria for probable sarcopenia were established using the handgrip thresholds set by the EWGSOP2. Women identified as having probable sarcopenia displayed markedly lower MIHE, diminished gait speed, inferior performance in chair-rise and Timed Up-and-Go tests, decreased muscle mass, and a lower resting metabolic rate than their non-sarcopenic counterparts. MIHE exhibited robust correlations with muscle mass, resting metabolic rate, and functional performance metrics. These results suggest that assessments of lower limb and trunk strength yield pertinent insights beyond handgrip strength alone. Function-oriented evaluations may improve sarcopenia screening and facilitate the identification of older women at risk of functional and metabolic deficiencies in community-based environments. Full article