Search Results (117)

Island electrical networks often face stability and resilience issues due to their weakly meshed structure, which lowers system inertia and compromises supply continuity. This challenge is further intensified by the increasing integration of renewable energy sources, promoted by decarbonization goals, whose intermittent and variable nature complicates grid stability management. To address this, Red Eléctrica de España—the transmission system operator of Spain—has planned several improvements in the Canary Islands, including the installation of new wind farms and a second transmission circuit on the island of La Palma. This new infrastructure will complement the existing one and ensure system stability in the event of N-1 contingencies. This article evaluates the stability of the island’s electrical network through dynamic simulations conducted in PSS^®E, analyzing four distinct fault scenarios across three different grid configurations (current, short-term upgrade and long-term upgrade with wind integration). Generator models are based on standard dynamic parameters (WECC) and calibrated load factors using real data from the day of peak demand in 2021. Results confirm that the planned developments ensure stable system operation under severe contingencies, while the integration of wind power leads to a 33% reduction in diesel generation, contributing to improved environmental and operational performance. Full article

Background/Objectives: Outdoor office work (OOW) has been shown to promote health and well-being and to reduce stress. However, few empirical studies have examined research-based, simple approaches to implementing OOW. In preparation for a larger study, we conducted a feasibility study focusing on limited efficacy testing of potentially relevant outcomes for future OOW research. Methods: The simple Pop Out OOW programme consists of three workshops and access to online tutorials designed to support employees in transitioning relevant everyday office tasks outdoors. Before and after a 12-week intervention, employees from five small- and medium-sized Danish companies (N = 70) reported their weekly number of days including OOW, connectedness to nature (CNS and INS), Perceived Stress Scale (PSS), and well-being (WHO-5) scores. Results: At baseline, higher CNS scores were associated with a greater number of days including OOW per week (r = 0.25, p = 0.020). Following the intervention, participants reported a significant increase in the number of days per week with OOW (p < 0.01, d = 0.65). CNS scores also increased significantly (p = 0.019, d = 0.32). No significant changes were observed in stress or well-being scores across the entire sample. However, participants with PSS scores exceeding a national Danish criterion for high stress (n = 11) exhibited a significant and substantial reduction in perceived stress (p < 0.01, d = 1.00). Conclusions: Days including OOW, along with PSS and CNS scores, may serve as relevant outcome measures in future studies evaluating interventions aimed at promoting OOW. These outcomes should be assessed in larger and more diverse and controlled samples to establish generalisability. Full article

High-precision indoor positioning technology is increasingly prominent in its application value in emerging fields such as the Industrial Internet of Things, smart cities, and autonomous driving. 5G networks can transmit large-bandwidth signals and have the capability to transmit and receive signals with multiple antennas, enabling the simultaneous acquisition of angle and distance observation information, providing a solution for high-precision positioning. Differences in the types and quantities of observation information in complex environments lead to positioning scenarios having a multimodal nature; how to propose an effective observation model that covers multimodal scenarios for high-precision robust positioning is an urgent problem to be solved. This paper proposes a three-stage time–frequency synchronization method based on group peak time sequence tracing. Timing coarse synchronization is performed through a group peak accumulation timing coarse synchronization algorithm for multi-window joint estimation, frequency offset estimation is based on cyclic prefixes, and finally, fine timing synchronization based on the primary synchronization signal (PSS) sliding cross-correlation is used to synchronize 5G signals to chip-level accuracy. Then, a tracking loop is used to track the Positioning Reference Signal (PRS) to within-chip accuracy, obtaining accurate distance information. After obtaining distance and angle information, a high-precision positioning method for multimodal scenarios based on 5G heterogeneous measurement combination is proposed. Using high-precision angle observation values as intermediate variables, this algorithm can still solve a closed-form positioning solution under sparse observation conditions, enabling the positioning system to achieve good positioning performance even with limited redundant observation information. Full article

Background/Objectives: The COVID-19 pandemic affected frontline workers’ mental health, including healthcare workers, firefighters, and police officers, increasing the need for effective interventions. This study focuses on the pandemic’s psychological impact, perceived stress, depression/anxiety symptoms, and resilience, examining if a brief virtual reality (VR)–based relaxation session could reduce psychological symptoms. Methods: In this preliminary study with data collected in 2025 from frontline workers who had served during the acute phase of the COVID-19 pandemic, 54 frontline workers completed a baseline assessment of the perceived psychological impact of COVID-19 pandemic, general perceived well-being, perceived stress (PSS-4), anxiety/depression (PHQ-4) and resilience (RS-25). Each participant then engaged in a 10-min immersive VR relaxation session featuring a calming 360° nature environment with audio guidance, after which questionnaires were re-administered. Paired samples t-tests and repeated-measures ANOVA evaluated pre-/post-session differences, and a hierarchical multiple linear regression model tested predictors of the change in stress. Results: Pre-session results showed moderate perceived stress and resilience and low depression/anxiety. Occupation groups varied in baseline stress, mostly reporting negative pandemic psychological effects. After VR, significantly perceived well-being increased, and stress decreased, whereas depression/anxiety changes were nonsignificant. Repeated-measures ANOVA revealed a main effect of time on stress (p = 0.003) without occupation-by-time interaction (p = 0.246), indicating all occupational groups benefited similarly from the VR session. Hierarchical regression indicated baseline depression and higher perceived pandemic-related harm independently predicted greater stress reduction, whereas resilience and baseline anxiety showed no statistically significant results. Conclusions: A single VR relaxation session lowered perceived stress among frontline workers, particularly those reporting higher baseline depression or pandemic-related burden. Limitations include the absence of a control group. Results support VR-based interventions as feasible, rapidly deployable tools for high-stress settings. Future research should assess longer-term outcomes, compare VR to alternative interventions, and consider multi-session protocols. Full article

Polysaccharides (PSs) are the most abundant carbohydrates in nature, performing essential biological functions such as immune system regulation, structural support, and cell communication. PSs from marine microalgae have gained increasing attention due to their diverse biological activities and potential applications in various fields, including the human health sector. These natural macromolecules, primarily composed of glucose, xylose, galactose, rhamnose, and fucose, exhibit bioactive properties influenced by their molecular weight, sulfation degree, and structural complexity. Microalgal PSs can function as antiviral, antimicrobial, antioxidant, immunomodulatory, and antitumor agents, making them promising candidates for pharmaceutical and nutraceutical applications. Additionally, their physicochemical properties make them valuable as bioactive ingredients in cosmetics, serving as hydrating agents, UV protectants, and anti-ageing compounds. The production of PSs from microalgae presents a sustainable alternative to terrestrial plants, as microalgae can be cultivated under controlled conditions, ensuring high yield and purity while minimizing environmental impact. Despite their potential, challenges remain in optimizing extraction techniques, enhancing structural characterization, and scaling up production for commercial applications. This review provides an overview of the principal biological activities of PSs from eukaryotic microalgae and their possible use as ingredients for cosmetic applications. Challenges to address to implement their use as products to improve human health and wellbeing are also discussed. Full article

Natural polysaccharides (PSs) have shown inhibitory effects on differentiated cancer cells (DCCs), but their activity against cancer stem cells (CSCs) remains poorly understood. Here, we report that PSs from wheat cell cultures (WCCPSs) inhibit the proliferation of both DCCs and CSCs derived from HCT-116 colorectal cancer cells. Among them, NA and DC fractions showed the strongest anti-CSC activity. NA, rich in xylose, was effective at lower concentrations, while DC, enriched in xylose and galacturonic acid (GalUA), exhibited higher potency, with a lower IC₅₀ and preferential activity against CSCs at higher doses. WCCPSs reduced β-catenin levels, and some fractions also downregulated Ep-CAM, CD44, and c-Myc. Notably, DC increased caspase-3 without inducing cytochrome C and caspase-8 overexpression, suggesting a mechanism promoting CSC differentiation rather than apoptosis. Correlation analysis linked xylose content to reduced c-Myc expression, and GalUA levels to increased caspase-3. These results suggest that WCCPS bioactivity may be related to their monosaccharide composition. Overall, our findings support the potential of wheat-derived PSs as CSC-targeting agents that suppress self-renewal and promote differentiation, offering a promising approach to reduce tumor aggressiveness and recurrence. Full article

In this paper, the natural waste pinecone as a carbon precursor for the generation of satisfactory sulfur host materials in lithium–sulfur batteries was realized by introducing molybdenum carbide nanoparticles into the derived carbon structure. The conductive pinecone-derived carbon doped with N, O reveals an expansive specific surface area, facilitating the accommodation of a higher sulfur load. Moreover, the integration of Mo₂C nanoparticles also significantly enhances its chemical affinity and catalytic capacity for polysulfides (LiPSs) to alleviate the shuttle effect and accelerate sulfur redox conversion. As a result, the WPC-Mo₂C/S electrode displays excellent electrochemical performance, including a low capacity decay rate of 0.074% per cycle during 600 cycles at 1 C and an outstanding rate capacity (631.2 mAh g⁻¹ at 3 C). Moreover, with a high sulfur loading of 5.5 mg cm⁻², the WPC-Mo₂C/S electrode shows a high area capacity of 5.1 mAh cm⁻² after 60 cycles at 0.2 C. Full article

Phenylalanine (Phe)-free protein substitutes (PSs) are used to provide an adequate intake of amino acids (AAs), except Phe, allowing control of blood Phe levels in patients with Phenylketonuria (PKU). Although indicated as a standard dietary treatment for these patients, free AAs mixtures are not absorbed as natural proteins, thus creating an oxidized and inflamed state in the intestine. Nowadays, PSs on the market also include slow-release amino acids (SR-AAs) formulas. The present work aims to investigate the effects of an SR-AAs formula on both oxidative and inflammatory status in human intestinal Caco-2 cells, comparing its mechanism of action with that of a mixture of free AAs. In more detail, oxidative stress and inflammation were induced at the cellular level using H₂O₂ and lipopolysaccharides (LPSs), respectively, and both free AAs and SR-AAs PSs were tested to evaluate if they were able to restore a more balanced condition. According to our findings, free AAs aggravate the intestinal oxidative and inflammatory status caused by H₂O₂ and LPS in human intestinal Caco-2 cells, which SR-AAs significantly improve. In conclusion, our results offer preclinical novelty on these products’ mechanisms of action, thus improving the dietary management of patients with PKU. Full article

The Spent Fuel Pool (SFP) is part of the fuel handling and storage system and is generally arranged in an independent building on the Nuclear Island (NI) of Nuclear Power Plants (NPPs). According to the HAF102—Safety Regulations for Nuclear Power Plants Design, it is necessary to ensure the smooth implementation of the safety functions of the SFP under various operating conditions. If the SFP is arranged inside containment, its protection requirements for external events will be significantly reduced, but new requirements will be raised for accident response measures inside containment, namely, that the system performs safety functions to ensure the long-term cooling of both the reactor core and spent fuel components. The reactor type that employs passive principles to realize the above functions requires a reasonable design of the layout of the Passive Safety System (PSS) to ensure nuclear safety. Based on existing reactor schemes, this article analyzes the design of a full-range passive concept for these reactors with an SFP built-in containment. The main focus of this article is on the long-term natural circulation process of PSS in containment under conditions of hypothetical accidents, and the arrangement of system items. Conceptual plans for the operation and layout of the safety system are obtained, which can provide references for the research and design of NPPs with SFP built-in containment. Full article

Purpose: Porto-systemic shunting (PSS) in patients with Abernethy malformation (AM) or obstruction of the portal vein (OVP) is often associated with normal liver parenchyma and hepatic function. This association provides an interesting natural model for studying the brain functional connectivity changes secondary to PSS but independently from hepatic (dys)function. Because PSS can be eliminated with appropriate interventions, these particular conditions offer a unique physio-pathological model where the same patient can be studied in both “active PSS” and “absent PSS” conditions (pre- and post-cure analyses). Methods: Four children (<18 years) who were evaluated for Abernethy malformation (n = 2) or portal cavernoma (n = 2) and underwent corrective surgery (living-donor liver transplantation for AM, or Meso-Rex bypass for OPV, respectively) were included in the study. Brain magnetic resonance imaging and resting-state functional magnetic resonance imaging (rest-fMRI) were acquired in all patients before and after the corrective surgery. A functional connectome analysis was performed before (“active PSS” condition) and after (“absent PSS”—physiological condition) the cure of PSS. Results: As a result of the cancelation of PSS, rest-fMRI connectomics revealed a statistically significant (p < 0.05 family-wise error) improvement in global brain functional connectivity in both groups following each surgical procedure. Conclusions: In this clinical model of isolated PSS (with absence of hepatic dysfunction), brain functional connectivity was altered even in young patients and in the absence of hyperammonemia; moreover, specific interventions to cancel out PSS consequently significantly improved brain functional connectivity. Full article

The European Ground Motion Service (EGMS) and geospatial data are integrated in this paper to evaluate ground deformation and its effects on critical infrastructures in the Preveza Regional Unit. The EGMS, a new service of the Copernicus Land Monitoring Service, employs information from the C-band Synthetic Aperture Radar (SAR)-equipped Sentinel-1A and Sentinel-1B satellites. This allows for the millimeter-scale measurement of ground motion, which is essential for assessing anthropogenic and natural hazards. The study examines ground displacement from 2018 to 2022 using multi-temporal Synthetic Aperture Radar Interferometry (MTInSAR). The Regional Unit of Preveza was selected for study area. According to the investigation, the area’s East–West Mean Velocity Displacement varies between 22.5 mm/y and −37.7 mm/y, while the Vertical Mean Velocity Displacement ranges from 16 mm/y to −39.3 mm/y. Persistent Scatterers (PSs) and Distributed Scatterers are the sources of these measurements. This research focuses on assessing the impact of ground deformation on 21 school units, 2 health centers, 1 hospital, 4 bridges and 1 dam. The findings provide valuable insights for local authorities and other stakeholders, who will greatly benefit from the information gathered from this study, which will lay the groundwork for wise decision-making and the creation of practical plans to strengthen the resistance of critical infrastructures to ground motion. Full article

Objective: Numerous studies have highlighted the prevalence of mental health disorders among healthcare professionals during the COVID-19 pandemic, with varying indications of emotional strain. This study compares the psychological functioning of healthcare workers at the onset of the pandemic and two years later, offering a comprehensive assessment of their emotional and mental health status in the evolving context of COVID-19. Methods: This longitudinal analysis examined the relationship between stress, emotional processing, and their positive/negative impacts on medical personnel working in Polish hospitals and outpatient clinics in 2020 (n = 285) and 2022 (n = 252). The study employed the Toronto Alexithymia Scale-20 (TAS-20), Cohen’s Perceived Stress Scale (PSS-10), Mini-COPE, Acceptance of Illness Scale (AIS), Emotional Processing Scale (EPS), STAI, and PANAS to assess psychological responses and coping mechanisms. Results: Findings revealed a significant increase in denial, substance use, self-blame, negative mood, and impaired psychological and somatic functioning, alongside heightened symptoms of depression and anxiety. Conversely, a marked decrease in planning, positive reinterpretation, acceptance, religious coping, and seeking social support (both emotional and instrumental) was observed over the two-year period. Conclusion: The prolonged nature of the COVID-19 pandemic has profoundly affected the psychological resilience of healthcare professionals, eroding critical emotional resources necessary for maintaining interpersonal relationships and mental well-being. These results underscore the need for targeted interventions to support the mental health of medical staff in the ongoing crisis. Full article

Photodynamic therapy (PDT) has emerged as a promising therapeutic approach owing to its non-invasive nature and minimal toxicity. PDT involves the administration of a photosensitizing agent (PS), which, upon light activation, induces a photodynamic reaction (PDR), leading to targeted cell destruction. However, developing resistance to PDT poses a significant challenge to its effectiveness. Various factors, including properties and administration of PSs, mediate this resistance. Despite the widespread use of substances like 5-aminolevulinic acid (5-ALA) and protoporphyrin, their efficacy is limited due to restricted tumor penetration and a lack of tumor targeting. To address these limitations, nano-delivery techniques and newer PSs like Aza-BODIPY and its derivatives, which offer enhanced tissue penetration, are being explored. In this paper, we provide an overview of resistance mechanisms in PDT and discuss novel methods, substances, and technologies to overcome resistance to improve clinical outcomes in tumor treatment. Full article

Steroidal 5α-reductase type 2 (S5αR2) is a key enzyme involved in the conversion of testosterone (TST) to dihydrotestosterone (DHT), a crucial process in the development of benign prostatic hyperplasia (BPH). Phytosterols (PSs), natural plant-derived compounds, have been proposed as potential inhibitors of S5αR2, but studies on their efficacy are limited. This study evaluates the inhibitory effects of three PSs (β-sitosterol, stigmasterol, and campesterol) on S5αR2 activity using a combined in vitro and in silico approach. The inhibitory activity of the respective PSs was assessed in vitro, by measuring TST and DHT, while molecular docking and dynamics explored PS interactions with S5αR2’s active site. The in vitro tests indicated significantly higher IC₅₀ values (β-sitosterol, 3.24 ± 0.32 µM; stigmasterol, 31.89 ± 4.26 µM; and campesterol, 15.75 ± 5.56 µM) for PSs compared to dutasteride (4.88 × 10⁻³ ± 0.33 µM), suggesting a lower efficiency in inhibiting S5αR2. The in silico studies confirmed these observations, explained by the lower binding affinity identified for PSs to the enzyme’s active site in the molecular docking studies and the reduced stability of the interactions with the active site of the enzyme during the molecular dynamics simulations compared to dutasteride. The results suggest that PSs exhibit low-to-negligible inhibitory activity against S5αR2 (µM range) compared to the synthetic inhibitor dutasteride (nM range). Among the three PSs studied, β-sitosterol showed the highest inhibitory activity and the best stability in its interaction with S5αR2, when compared with stigmasterol and campesterol. Full article

Over the last ten years, there has been a remarkable enhancement in the power conversion efficiency (PCE) of perovskite solar cells (PSCs), with poly (3,4-ethylenedioxythiohene):poly (styrenesulfonate) (PEDOT:PSS) emerging as a prevalent choice for the hole transport layer (HTL). Nevertheless, the evolution of the widely utilized PEDOT:PSS HTL has not kept pace with the swift advancements in PSC technology, attributed to its suboptimal electrical conductivity, acidic nature, and inadequate electron-blocking performance. This study presents a novel approach to enhance the HTL by introducing molybdenum oxide (MoO₃) into the PEDOT:PSS, leveraging the conductivity and solution processing compatibility of MoO₃. Two methods for MoO₃ integration were explored: an ammonium molybdate tetrahydrate (AMT) precursor and the direct addition of MoO₃ nanoparticles. The carrier dynamics of PSCs modified by MoO₃ are significantly optimized. Therefore, the PCE of the device modified by AMT and molybdenum oxide is increased to 18.23 and 19.64%, respectively, and the stability of the device is also improved. This study emphasizes the potential of MoO₃ in contributing to the development of more efficient and stable PSCs. Full article