Search Results (402)

Background: Tinnitus is a prevalent auditory disorder associated with maladaptive cortical plasticity and aberrant neural synchronization across auditory and non-auditory brain networks. Acoustic desynchronization-based sound therapies, such as coordinated reset neuromodulation, aim to counteract pathological oscillatory patterns but commonly require prolonged daily listening sessions and specialized delivery formats, which may limit their accessibility and practicality in routine clinical settings. To address this limitation, a modified desynchronization protocol embedding therapeutic tones within music was developed to improve tolerability and engagement. This study aimed to evaluate the clinical effects of modified Music-Integrated Desynchronization Sound Therapy (mMIDST) on tinnitus severity in patients with chronic tinnitus. Methods: In this prospective, randomized, controlled, single-blind pilot trial conducted at the Otolaryngology Department of Hospital Clínico Universidad de Chile (Santiago, Chile) between July 2024 and July 2025, adults aged 18–75 years with chronic non-pulsatile tinnitus were assigned to receive either mMIDST or an active control intervention consisting of low-frequency stimulation (LFS) embedded within identical music tracks. Participants listened to personalized sound files for one hour daily, five days per week. Tinnitus severity was assessed using the Tinnitus Handicap Inventory (THI), with audiometric evaluations performed at baseline and after one, two, and three months. Between-group differences were analyzed using the Mann–Whitney U test. Results: Twenty-five participants completed the study (15 mMIDST, 10 LFS). Baseline audiometric thresholds and THI scores were comparable between groups. The mMIDST group showed significantly greater reductions in THI scores than the LFS group at two and three months of treatment (p < 0.05). Conclusions: mMIDST was associated with time-dependent improvements in tinnitus-related distress compared with an active control condition. Embedding desynchronization-based tonal stimulation within music may represent a promising and well-tolerated non-invasive approach for chronic tinnitus management. Full article

The Active Music Programme (MAP) is an interdisciplinary initiative designed to foster inclusion, communication, and emotional well-being through participatory music-making. Integrating active music education, guided improvisation, and creative interaction, MAP seeks to enhance quality of life for individuals with diverse abilities. This pilot project, implemented in a special education centre with adolescents and adults with Autism Spectrum Disorder (ASD), combines weekly collaborative sessions led by music and education professionals. Using a qualitative, participatory framework, the study aims to examine how musical engagement is expected to support shared attention, emotional regulation, and social connection, positioning MAP as a replicable model for inclusive education and community practice. Full article

Background/Objectives: Breast cancer is the most prevalent malignancy among women worldwide and remains a major cause of morbidity and mortality. Conventional treatments, while effective, often produce physical and psychological adverse effects that impair quality of life. Complementary therapies (CTs) have gained prominence as supportive strategies to mitigate these effects. This systematic review aimed to evaluate the potential benefits of CTs in women with breast cancer undergoing or having completed chemotherapy and radiotherapy. Methods: Following PRISMA 2020 guidelines and Cochrane standards, a systematic search was conducted in PubMed, CINAHL, Web of Science, and Scopus for studies published up to March 2026. Randomized controlled trials assessing CTs in breast cancer patients were included. Methodological quality was appraised using the PEDro scale, and risk of bias was evaluated using the Cochrane RoB 2 tool. Results: Thirty-two RCTs met the inclusion criteria. The interventions included acupuncture and related techniques, mindfulness-based therapies, massage, dance–movement therapy, music therapy, slow breathing, prayer, and natural products. Overall, CTs produced improvements in pain, fatigue, anxiety, depression, sleep quality, and social well-being, though the effects were sometimes therapy-specific and varied. Conclusions: Complementary therapies represent non-pharmacological strategies that may offer potential benefits across physical, emotional, and social outcomes in women with breast cancer. However, mixed results in certain therapies indicate that conclusions must be drawn cautiously. Future research should pursue methodological consistency and longer follow-ups. Full article

Alzheimer’s disease (AD) results in progressive neural degeneration that causes cognitive and non-cognitive symptoms (NCSs). While cognitive symptoms commonly prompt a formal diagnosis, NCSs also contribute significantly to disability, caregiver burden, and overall disease progression. NCSs are rooted in both physiological and psychological consequences of AD, resulting in apathy/motivation loss, emotional dysregulation, anxiety, depression, agitation, and sleep disturbances. Despite progresses in pharmaceutical management of NCSs, variable efficacy, unwanted side effects, and lack of symptom-wide effectiveness often limit therapeutic practicality for people with AD, suggesting a need for the identification of practical adjunctive treatments. Mechanistic evidence of using music interventions as complementary treatment to manage cognitive symptoms in AD has been established, but the potential benefits for NCSs are less clear. Music interventions have the potential to adaptatively alter mechanisms underlying NCSs that span both physiological and psychological domains of symptomology. Physiologically, music has been shown to alter autonomic activity, neurotransmitter release in various brain regions, and mediate hormonal regulation. Psychologically, music interventions have been shown to enhance mechanisms related to motivation, emotional regulation, and resilience to mental stress. Behavioral and neuroimaging evidence further supports this and suggests that the mechanisms of music-induced benefits may aid in counteracting NCSs in people with AD. While the neuromechanistic rationale for music-induced benefits towards NCSs in AD is promising, findings are largely fragmented, leaving therapeutic application difficult. Accordingly, the purpose of this review is to integrate current mechanistic evidence and clinical findings for a rationale and framework for the therapeutic application of music interventions to combat NCSs in AD. Overall, evidence largely supports the use of music as an adjunctive, feasible, and non-invasive therapeutic tool to improve various aspects of NCSs in AD. The translation of mechanistic findings to therapeutic utility are further highlighted. Limitations, challenges, and future directions necessary to fully realize music benefits on NCSs in AD are also discussed with a goal of therapeutic translation. Full article

Objective: This pilot study aimed to explore how a receptive music intervention, based on musical genres reflecting maternal listening preferences during pregnancy, affects distress levels in Italian preterm infants. Specifically, it investigated the effects of soft pop/rock music, compared with classical music, on infants’ LF/HF ratio (derived from heart rate variability [HRV]) and peripheral oxygen saturation (SpO₂), which were used as physiological markers of distress. Method: This retrospective observational pilot study analyzed clinical data routinely collected between May 2014 and January 2015 from 27 preterm infants (gestational age 23–32 weeks; birth weight < 1500 g) who received receptive music therapy as part of standard family-centered care in the NICU. Maternal listening preferences during pregnancy were assessed in 30 mothers via an ad hoc questionnaire; a content analysis identified, at the group level, the three most frequently reported artists (i.e., Jovanotti, Vasco Rossi, and W. A. Mozart), which were used to create three standardized playlists. According to the internal clinical procedure, each infant underwent four sessions on consecutive days: a no-music condition on Day 1, followed by the three music conditions on Days 2–4 in randomized order. The LF/HF ratio and SpO₂ were measured at five time points per session (one pre-test, three intra-session time points, and one post-test). Wilcoxon signed-rank tests were used to compare conditions and time points, with effect sizes and a Benjamini–Hochberg (FDR) correction for multiple comparisons. Results: The LF/HF ratio did not differ significantly across music conditions or relative to the no-music condition. SpO₂ was higher during the Mozart condition than during the no-music condition at three of the five time points; this association remained significant after FDR correction, with medium-to-large effect sizes. No effect was observed for the soft pop/rock conditions on physiological indexes. Conclusions: Receptive music therapy based on maternal listening during pregnancy was not associated with changes in the LF/HF ratio. The Mozart condition was associated with higher SpO₂ than the no-music condition. Given the small sample, the single-center setting, and the retrospective observational design, these findings are preliminary and require confirmation in larger, adequately powered prospective trials. Future studies should also examine the specific musical features (e.g., tempo, harmonic structure, voice timbre) that may drive these physiological responses. Full article

Background/Objectives: Spectral resolution is strongly associated with speech perception for adult cochlear implant users, but the developmental trajectory of spectral resolution in childhood is more complex and far less understood. Music-based training presents a unique opportunity to address this gap, as musical stimuli feature spectral complexity and fine frequency cues which map to spectral resolution. This study explored if a 12-week music-based intervention could support better spectral resolution in children with cochlear implants. Methods: Twelve children with cochlear implants participated in this longitudinal, repeated-measures study. The music training intervention consisted of group-based in-person music therapy and a take-home music app. Participants (six boys, six girls; M age = 7.3 years) were pseudo-randomized into an immediate training group (n = 4) or delayed-start waitlisted group (n = 8). Inclusion criteria required bilateral moderate-to-profound sensorineural hearing loss, prelingual device fitting, and consistent bilateral device use. Eight children had bilateral CIs and four were bimodal listeners. Results: Spectral resolution perception was significantly enhanced after participating in the music intervention with a mean increase of 2 rpo, F(3, 10.7) = 3.859, p = 0.017. Previous engagement with music and age were not associated with spectral resolution. Conclusions: Despite the known limitations of CIs on spectral resolution, the results of this study indicate that music training can improve spectral resolution perception in children using CIs. Full article

Background: Music listening is increasingly applied in medical and healthcare settings as a non-pharmacological intervention to modulate psychophysical outcomes such as anxiety, pain, stress, mood, and physiological parameters. Despite a rapidly expanding evidence base, receptive music-based interventions remain highly heterogeneous with respect to theoretical rationale, music design, and methodological rigor. Objective: The primary aim of this review was to critically examine methodological and conceptual limitations of music listening approaches (based on pre-recorded music listening, without the presence of the music therapist during the listening phase) and to map the range of such interventions across clinical domains. Methods: A systematic search of PubMed was independently conducted by two reviewers for randomized controlled trials published between January 2020 and December 2025. Eligible studies investigated psychophysical outcomes of pre-recorded music listening in clinical or medical populations. Studies involving music listening in relational settings, live music, multimodal interventions, or neuromotor rehabilitation were excluded. Results: Of 280 records initially identified, 63 studies met the inclusion criteria. Most studies employed conventional familiar music, frequently self-selected by participants. Fewer than half reported explicit musical parameters, and only five studies documented the involvement of a certified music therapist. Substantial heterogeneity was observed in music listening experiences, potentially confounding outcome interpretation. Conclusions: Although music listening interventions appear feasible and potentially beneficial across diverse clinical contexts, major methodological and conceptual limitations persist. Greater involvement of music therapy professionals, standardized reporting of musical parameters, clearer theoretical rationales linking musical structure to clinical outcomes, and improved control group design are required to enhance reproducibility, interpretability, and clinical translation. Full article

This review aimed to evaluate the effectiveness and feasibility of non-pharmacological interventions to reduce anxiety and agitation and improve observable wellbeing and patient engagement for people with dementia in acute hospital environments. The global increase in dementia has resulted in a substantial number of acute hospital beds occupied by people with dementia. Hospitalisation can exacerbate behavioural and psychosocial symptoms of dementia (BPSD) including anxiety and agitation, which negatively affects patient experience, safety and care. Clinical guidance recommends non-pharmacological interventions as a first-line tactic to manage BPSD. However, evidence for the effectiveness and feasibility of these interventions remains fragmented in such pressured environments. A systematic search of seven databases was conducted for studies published in the last ten years (2015–25), following the PRISMA guidelines. Fourteen studies met the eligibility criteria and included a total of 749 people with dementia. Studies used mixed interventions; music, music therapy and person-centred care highly featured and most studies reported reductions in observable BPSD during or immediately after interventions. Secondary benefits included wellbeing, reduced psychotropic medicine use, length of hospitalisation and high staff and patient acceptability. There was limited evidence for sustained effects beyond intervention. This review supports the feasibility and effectiveness of non-pharmacological interventions in acute hospitals to support dementia-inclusive, person-centred care. Full article

Generative artificial intelligence (AI)-based music generation has the potential to create new opportunities for music therapy; however, integrated examinations of generative AI and music therapy remain limited. This paper provides a focused survey of recent studies that apply generative AI within music therapy-related contexts, examining how such approaches have been explored in relation to therapeutic considerations, including emotional and physiological regulation. Rather than offering an exhaustive historical review, we analyze generative AI-augmented music therapy systems from a system-level perspective, focusing on their overall design and implementation. Based on this survey, we discuss open research challenges at the intersection of generative music, adaptive systems, and digital health, and outline future research directions toward scalable and personalized generative AI-based music therapy. Full article

Background/Objectives: Childhood hearing loss (HL) affects auditory, linguistic, and social development. Alongside conventional rehabilitation, music-based interventions have gained increasing attention for their potential to support both auditory and non-auditory domains. This narrative review aims to summarize current evidence on the use of music-based interventions in children with HL. Methods: A narrative review of the literature was conducted, examining studies involving pediatric cochlear implant or hearing aid users. Publications were categorized into three main areas: musical auditory perception, musical training, and music therapy. Results: Studies on musical auditory perception demonstrate persistent limitations in pitch and timbre perception in children with HL, while rhythmic abilities appear relatively preserved. Musical training interventions, particularly those targeting rhythm, have been associated with improvements in auditory perception, linguistic processing, and selected cognitive skills, although parental involvement and long-term designs remain limited. Existing literature on music therapy is scarce but suggests potential benefits extending beyond auditory skills to emotional regulation, social interaction, and quality of life. Conclusions: Music-based interventions represent a promising complementary approach in pediatric hearing rehabilitation. While musical training is more widely studied, music therapy is still underrepresented despite its holistic focus. Further structured studies are needed to define standardized protocols and outcome measures for music therapy in children with HL. Full article

Music therapy (MT) is increasingly being integrated into intensive care unit (ICU) settings to modulate pain, stress, and emotional dysregulation. Although clinically promising, objective biomarkers for quantifying its neurophysiological effects are still missing. In this context, the electroencephalogram (EEG) represents a valid tool to assess cortical dynamics associated with cognitive–affective engagement elicited by MT. Our study aims to evaluate the role of electroencephalography as an objective tool for monitoring cortical responses to MT in the ICU. EEGs acquired from nine burn patients undergoing MT in the ICU were considered. Signals were preprocessed to improve the signal-to-noise ratio. Then, six frequency bands (delta, theta, alpha, beta, gamma, and sensorimotor rhythm) were extracted to compute band powers and derive 37 involvement indexes, which were statistically compared across three experimental phases: before, during, and after MT. Results demonstrate that involvement indexes effectively capture neurophysiological shifts induced by MT. Significant differences were observed in 22 indexes when comparing During-MT and Post-MT phases, with 2 indexes being statistically different also when comparing During-MT and Pre-MT phases; 5 indexes differed statistically when comparing Pre-MT and Post-MT phases. These results suggest a transient cortical engagement elicited during MT in ICU settings. Our findings align with previous research reporting EEG (and certain EEG-derived involvement indexes) sensitivity to capture music-induced cognitive and emotional modulation. This confirms electroencephalography potential to objectively reflect MT effects and support its integration in multidisciplinary burn care; however, analysis on larger cohorts is necessary to validate EEG as a clinical tool in MT. Full article

Elementary music teachers in the United States face many challenges today, including an increasing cultural divide between teachers and students, worsening student behavior, and excessive exposure to technology in children’s lives. These challenges are magnified due to the hundreds of students elementary music teachers see weekly, the lack of teaching and planning time, and inadequate teaching resources, making it difficult to fully understand the culture and learning needs of every child. However, music educators may find culturally sustaining pedagogy (CSP) a useful tool for meeting the needs of a diverse student body. Further, when teachers engage in kid culture, the environments and activities that only children have, there is a plethora of music and media to use that children prefer that can help increase engagement and reduce behavioral problems. In this Perspective article, I provide three sample lessons that model instructional strategies that challenge current systems of power and representation in music education and center student agency through singing, chanting, moving, playing, and creating. Using repertoire that students already know and prefer, such as “Old Town Road,” Fortnite dances, and the song “See You Again”, draws from children’s funds of knowledge. Moving away from the Western art music canon and traditional formal education structures (like standard notation) in favor of learning by ear, peer collaboration, and improvisation decolonizes the curriculum. Critical reflexivity occurs when the teacher acts as a learner, constantly adjusting lessons to ensure student agency and addressing ethical issues, such as the intellectual property rights of creators whose work is used in media like Fortnite. By using melodies, songs, and video game movements children already know, music teachers can use the materials and learning processes in kid culture to engage in culturally sustaining pedagogy. I aim to inspire educators and researchers to reflect on sustaining children’s dynamic, cultural practices and better understand how to authentically bring popular music and media into elementary music lessons to provide a more engaging, relevant, and transformative music education. Full article

Background: Peripheral venous cannulation is one of the most common clinical procedures, yet it often causes significant pain, anxiety, and discomfort for patients. While pharmacological methods exist, non-pharmacological interventions offer a low-cost, low-risk alternative that eliminates waiting times for anesthetic onset. The aim of this review is to synthesize the various nonpharmacological interventions for procedural pain reduction during PIVC in adults, covering interventions ranging from psychological distraction to advanced procedural support technologies. Methods: A systematic review was conducted following PRISMA 2020 guidelines and the Joanna Briggs Institute (JBI) framework. Databases including PubMed, CINAHL, Web of Science, and Scopus were searched for studies published between 2015 and 2025. Inclusion criteria focused on randomized controlled trials (RCTs) and quasi-experimental studies involving adult patients undergoing PIVC. Results: Thirty studies (29 randomized controlled trials and one experimental study) were included in the final analysis. The interventions were categorized into three primary groups: distraction techniques, physical methods, and behavioral techniques. The application of virtual reality (VR), optical illusion cards, and music therapy significantly reduced pain scores and enhanced patient satisfaction. Similarly, physical methods, such as thermomechanical stimulation (e.g., the Buzzy^® device), local heat application, and vibration, were found to be effective in lowering pain intensity compared to standard care. Behavioral techniques, including the “cough trick,” diaphragmatic breathing, and the Valsalva maneuver, consistently demonstrated efficacy in reducing both procedural pain and anxiety. Notably, while most interventions successfully reduced pain, certain methods—such as near-infrared (NIR) vein visualization—improved procedural success rates without significantly altering the subjective perception of pain. Conclusions: Findings from this review suggest that non-pharmacological interventions may serve as effective, safe, and feasible adjuncts for pain management during peripheral venous cannulation. Techniques such as the cough trick and vibration-based devices are particularly recommended due to their ease of integration into routine nursing practice, potentially improving patient comfort and clinical outcomes. Full article

Emotions and affective responses are core intervention targets in music therapy. Through acoustic elements, music can evoke emotional responses at physiological and neurological levels, influencing cognition and behavior while providing an important dimension for evaluating therapeutic efficacy. However, emotions are inherently abstract and difficult to represent directly. Artificial intelligence models therefore provide a promising tool for modeling and quantifying such abstract affective states from physiological signals. In this paper, we propose a structured and explicitly factorized multi-modal representation learning framework for joint affective state and preference inference. Instead of entangling heterogeneous dynamics within monolithic encoders, the framework decomposes representation learning into cross-channel interaction modeling and intra-channel temporal–spectral organization modeling. The framework integrates electroencephalography (EEG), peripheral physiological signals (GSR, BVP, EMG, respiration, and temperature), and eye-movement data (EOG) within a unified temporal modeling paradigm. At its core, a Dynamic Token Feature Extractor (DTFE) transforms raw time series into compact token representations and explicitly factorizes representation learning into (i) explicit channel-wise cross-series interaction modeling and (ii) temporal–spectral refinement via learnable frequency-domain gating. These complementary structural modules are implemented through Cross-Series Intersection (CSI) and Intra-Series Intersection (ISI), which perform low-rank channel dependency learning and adaptive spectral modulation, respectively. A hierarchical cross-modal fusion strategy integrates modality-level tokens in a representation-consistent and interaction-aware manner, enabling coordinated modeling of neural, autonomic, and attentional responses. The entire framework is optimized under a unified multi-task objective for valence, arousal, and liking prediction. Experiments on the DEAP dataset demonstrate consistent improvements over state-of-the-art methods. The model achieves 98.32% and 98.45% accuracy for valence and arousal prediction, 97.96% for quadrant classification in single-task evaluation, and 92.8%, 91.8%, and 93.6% accuracy for valence, arousal, and liking in joint multi-task settings. Overall, this work establishes a structure-aware and factorized multi-modal representation learning framework for robust affective decoding and intelligent music therapy systems. Full article

Over the years, the impact of music on the prenatal and neonatal stages of human life has gained significant scientific attention. This study provides a comprehensive bibliometric review of research investigating how music influences fetal and newborn development. Using the Scopus and Web of Science databases, a search of relevant studies published in English between January 2006 and July 2025 was conducted, whose basic criterion was the use of the following keywords: “music” and “fetus” or “fetal”. Additional terms such as “fetus development”, “fetus heart rate”, “fetus movement”, “mother–fetus relationship”, “newborn”, etc., were also utilized. In result, 75 publications were selected, and their bibliographic data and full sources were retrieved. The included studies were grouped according to two perspectives that consider the impact of music (1) on the development of the fetus and the newborn, and (2) on maternal health and mother–fetus bonding. Using VOSviewer, bibliometric mapping was performed, which allowed to obtain keyword co-occurrence network and co-authorship network. The chosen literature was then quantitatively and qualitatively analyzed. The analysis revealed a sharp upward trend in publications starting in 2015, with a temporary decline in 2020 due to the COVID-19 pandemic. The highest number of publications were from Iran. The most investigated topics were related to the fetus heart and maternal health. The most common publication type and research methodology were, respectively, article and experiment. While the key authors Lordier, L., Filippa, M., Grandjean, D., and Monaci, M.G. lead the field, the co-authorship network remains fragmented into isolated and relatively small research groups. The Journal of Maternal–Fetal and Neonatal Medicine emerged as the leading publication outlet, while the study by Graven et al. entitled “Auditory Development in the Fetus and Infant” remains the most cited work. The keyword co-occurrence network allowed the identification of three main thematic clusters indicating the physiological, clinical, and therapeutic aspects of the impact of music on fetal and neonatal development. A qualitative analysis revealed that music plays a vital role in early human development and maternal well-being, demonstrating positive effects of auditory stimuli on fetal and newborn physiology, as well as on the mother–fetus relationship, while being a non-invasive and non-pharmacological method of intervention. However, the lack of a fully connected global research community and standardized protocols for, e.g., choosing the musical repertoire, sound administration, and the duration of exposure suggests the need for increased international collaboration to further integrate music therapy into standard clinical practices for prenatal and neonatal care. Full article