Search Results (609)

Background/Objectives: Obesity is a multifactorial condition and a major public health challenge. Conventional treatment centers on caloric restriction, which is often unsustainable and may cause stigma and psychoemotional harm. This study aimed to describe the methodology and assess the effects of a multicomponent nutritional intervention not focused on caloric restriction on psychoemotional outcomes. Women were selected as the target population because of the higher prevalence of obesity-related psychoemotional distress, body dissatisfaction, and weight-related stigma in this group, as well as their greater vulnerability to the psychosocial impacts of weight-focused interventions. Methods: This randomised, parallel, open-label trial included 89 obese women from primary care in Viçosa, Brazil. The participants were allocated into three groups: Group 1 (Control), which received a personalised hypocaloric diet (from 500 to 1000 kcal/day); Group 2 (NutrirCom (NutrirCom is a multicomponent, person-centred nutritional intervention protocol that is not focused on caloric restriction, conceived by a group of researchers at the Federal University of Viçosa for the care of women with obesity in Primary Health Care. It integrates nutritional, psychoemotional, behavioural, and social strategies, with an emphasis on promoting eating autonomy, mental health, and quality of life through a humanised, integrated, and sustainable approach, aiming to enhance the effectiveness of health care delivery and clinical practice)), which received 10 individual NutrirCom-based sessions; and Group 3 (NutrirCom + Social Support), which combined individual NutrirCom sessions with monthly group meetings for social support. Randomisation was stratified by body mass index via Excel^® with concealed allocation. The six-month intervention assessed changes in stress, anxiety, depression, and self-compassion, along with anthropometric and metabolic markers. Results: All groups presented reductions in waist circumference, fasting glucose, and total body fat, with increased lean mass. Anxiety remained unchanged in Group 1 but decreased significantly in Groups 2 (p = 0.002) and 3 (p = 0.005). Only Group 2 showed a significant reduction in depression symptoms (p = 0.023). Self-compassion improved significantly in groups 2 and 3. Conclusions: NutrirCom is a low-cost, scalable, and human-centered intervention that integrates emotional, social, and nutritional aspects of care. This approach shows promise as a sustainable strategy for obesity treatment in primary health care. Registration: Brazilian Registry of Clinical Trials (ReBEC) (no. RBR-87wb8x5). Full article

Background/Objectives: Self-care is a cornerstone of healthy aging and chronic disease management; however, evidence on the most effective intervention models for improving quality of life in older adults with chronic non-communicable diseases (NCDs) remains fragmented. This review aimed to evaluate the effectiveness of self-care interventions in promoting quality of life and health outcomes in older adults with NCDs. Methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251040613). Randomized and non-randomized clinical trials published between 2019 and 2024 were retrieved from Scopus, Web of Science, and EBSCOhost. Eligible studies included adults aged ≥60 years with NCDs receiving self-care interventions. Data extraction and risk of bias assessment were independently performed using Joanna Briggs Institute tools. Results: Twenty-nine studies involving 7241 older adults were included. Self-care interventions comprised nurse-led educational programs, digital health strategies, community- and peer-based approaches, and person-centered care models. Multicomponent and continuous interventions demonstrated consistent improvements in physical and psychological domains of quality of life, self-efficacy, autonomy, symptom management, and treatment adherence. Digital interventions enhanced monitoring and engagement, although their effectiveness varied according to sensory and health literacy limitations. Conclusions: Structured, person-centered, and nurse-led self-care interventions are effective in improving quality of life and autonomy among older adults with NCDs. These findings support their integration into primary and community-based care, reinforcing their relevance for clinical practice, care planning, and the development of assistive and educational strategies in aging care. Full article

The development of high-performance wood-based materials has attracted increasing interest as a means of enhancing the mechanical properties of wood for structural applications. Mechanical densification combined with chemical pretreatment is an effective approach; however, many reported methods rely on complex multi-component chemical systems or severe chemical conditions designed to dissolve lignin or hemicelluloses. In this study, a simplified NaOH-only pretreatment followed by hot-press densification was investigated, targeting selective cell-wall plasticization rather than extensive polymer dissolution. Juniper (Juniperus communis), hawthorn (Crataegus monogyna), and birch (Betula pendula) were used as samples of softwood and hardwood species. Wood specimens were pretreated in 1 M NaOH at 145 °C for 10–30 min and subsequently densified by radial compression. Changes in chemical composition were evaluated by HPLC after acid hydrolysis and FTIR spectroscopy, while microstructural changes were examined using SEM. Physical and mechanical properties were assessed through density measurements and three-point bending tests. The results show that NaOH-only pretreatment induces hemicellulose deacetylation and modification of interpolymer linkages without substantial changes in the main wood polymer contents. Densification resulted in effective lumen collapse and a compact microstructure, leading to a significant increase in density and mechanical properties. Overall, the results demonstrate that efficient wood densification and mechanical enhancement can be achieved by promoting polymer mobility through selective cleavage of interpolymer bonds, using a simplified, single-alkali pretreatment that reduces chemical complexity and material loss while avoiding extensive lignin or hemicellulose dissolution. Full article

Background: Workplace violence (WPV) is a pervasive occupational hazard in healthcare that undermines staff safety and quality of care. In Bulgaria, WPV remains widespread and underreported, despite recent legislative initiatives. This study assessed healthcare professionals’ perceptions of the effectiveness of WPV prevention strategies and examined how prior exposure shapes these perceptions. Methods: A nationwide cross-sectional online survey was conducted in December 2024 with 944 healthcare professionals from multiple sectors. Participants rated the perceived effectiveness of 11 prevention strategies, including environmental/security measures, organizational, and national-level interventions, on a three-point scale. Friedman ANOVA with Kendall’s W assessed overall strategy rankings, while Mann–Whitney U tests with rank-biserial correlations compared specific effectiveness ratings between subgroups defined by WPV exposure (experienced or witnessed vs. not exposed in the previous 12 months). Results: In the previous 12 months, 34.7% of respondents reported direct WPV, and 43.4% had either experienced or witnessed incidents. Friedman ANOVA indicated significant differences in perceived effectiveness across strategies (Kendall’s W = 0.13), with stronger differentiation among violence-exposed respondents (W = 0.37) than among non-exposed respondents (W = 0.09). National-level interventions and security/response measures were consistently ranked the highest. Mann–Whitney tests showed significantly higher endorsement of most strategies among violence-exposed professionals, with large effect sizes for security measures and enforcement of sanctions. Conclusions: Bulgarian healthcare professionals view WPV prevention as requiring a multicomponent approach that integrates robust national policy with organizational and environmental measures. Direct exposure to violence is associated with stronger support for security-focused and national interventions. These findings inform context-specific, evidence-based WPV prevention programs for Bulgarian healthcare facilities. Full article

Hetero-multicomponent metal oxide catalysts are attracting increasing attention for wastewater remediation due to their tunable band structures, synergistic redox activity, and enhanced stability. This review thoroughly evaluates recent progress in the synthesis and application of such catalysts, highlighting Ti–Cu–Zn nanostructures as a representative case study. We examine synthesis approaches—including hydrothermal, biosynthesis, precipitation, and spray-based methods, with additional insight into sol–gel and other less commonly applied techniques—with emphasis on their suitability for constructing layered and multicomponent heterostructures. Mechanistic aspects of photocatalysis, Fenton and Fenton-like processes, adsorption, and electrochemical routes are discussed, with particular focus on charge separation, reactive oxygen species (ROS) generation, and pollutant-specific degradation pathways. Comparative performance metrics against antibiotics, pesticides, dyes, and fertilizers are analyzed, alongside considerations of leaching, reusability, and scale-up potential. Importantly, while significant progress has been made for organic micropollutants, applications in heavy metal remediation remain scarce, highlighting an urgent research gap. By situating Ti–Cu–Zn systems within the broader class of multicomponent catalysts, this review not only synthesizes current advances but also identifies opportunities to expand their role in sustainable wastewater management, including field deployment, regulatory compliance, and integration into decentralized treatment systems. Full article

Magnesium hydride (MgH₂) is a promising solid-state hydrogen storage material owing to its high hydrogen capacity and low cost, yet its practical application is limited by sluggish kinetics, high operating temperatures, and poor cycling stability. Among various catalytic approaches, Fe-based catalysts have emerged as attractive candidates due to their abundance, compositional tunability, and effective promotion of hydrogen sorption reactions in MgH₂ systems. This review critically summarizes recent progress in Fe-based catalysts for MgH₂ hydrogen storage, encompassing elemental Fe, iron oxides, Fe-based alloys, and advanced composite catalysts with nanostructured and multicomponent architectures. Mechanistic insights into catalytic enhancement are discussed, with particular emphasis on interfacial electron transfer, catalytic phase evolution, hydrogen diffusion pathways, and synergistic effects between Fe-containing species and MgH₂, supported by experimental and theoretical studies. In addition to catalytic activity, key stability challenges—including catalyst agglomeration, phase segregation, interfacial degradation, and performance decay during cycling—are analyzed in relation to structural evolution and kinetic–thermodynamic trade-offs. Finally, a roadmap for the scalable design of Fe-based catalysts is proposed, highlighting rational catalyst selection, interface engineering, and compatibility with large-scale synthesis. This review aims to bridge fundamental mechanisms with practical design considerations for developing durable and high-performance MgH₂-based hydrogen storage materials. Full article

Individuals with developmental disabilities often experience physical and mental chronic conditions from early childhood, which can negatively affect their education, employment, and social participation without appropriate interventions. These impairments frequently limit the acquisition of essential daily living skills, including personal hygiene skills. This study examined a multicomponent intervention package—comprising video prompting, step-by-step instruction based on task analysis, systematic error correction, and reinforcement—to support the acquisition of handwashing skills for two adolescents with developmental disabilities (Autism Spectrum Disorder and Intellectual Disability) and toothbrushing skills for one adolescent. A nonconcurrent multiple-baseline design across participants and skills was employed, including baseline, intervention, maintenance, and generalization phases. The intervention was conducted over eight weeks. The results indicated low and stable baseline performance for both participants, followed by a systematic increase in performance after the introduction of the intervention, reaching accuracy levels between 80% and 91%. Participants demonstrated meaningful improvements in hygiene skill performance following intervention. These gains were maintained over time and generalized to new settings, although a few task steps continued to require prompting. Furthermore, teachers and parents rated the intervention as highly feasible, practical, and useful for supporting hygiene skills, while students reported enjoyment, perceived improvement, and willingness to participate again. Overall, the findings suggest that structured, evidence-based instructional approaches may support increased functional participation in essential daily living skills, particularly when complete independence may not be attainable for all individuals. Full article

This paper investigates the flame behavior and smoke pattern characteristics of lithium-ion battery (LIB) fires using an integrated experimental and numerical simulation approach. Based on fire dynamics theory, a jet flame model for LIB thermal runaway (TR) is developed to analyze the flame height and dynamic characteristics. The results reveal two distinct regimes in LIB jet flames: momentum-controlled dominance in the early TR stage (lasting approximately 3 s) and buoyancy-controlled dominance in subsequent combustion. The jet flame shifts from a momentum-dominated regime (Fr > 5) to a buoyancy-dominated plume (Fr < 5) as the vent velocity decays below 12 m/s. The simulated flame heights align with experimental measurements and the Delichatsios model, validating the numerical approach. Furthermore, the distribution of flame components (e.g., H₂, CO, CO₂, CH₄, C₂H₄) is analyzed, highlighting the influence of multi-component gases on combustion heterogeneity. Smoke pattern analysis demonstrates that soot deposition varies significantly between momentum- and buoyancy-controlled stages, with the former producing darker, concentrated deposits and the latter yielding wider, lighter patterns. These findings provide a theoretical basis for forensic fire investigation (accident reconstruction) and targeted suppression strategies for different combustion stages. Full article

Background: The traditional formula Liqi Yangyin (LQYY) has shown clinical and preclinical efficacy for depression with constipation, yet its molecular mechanisms remain incompletely defined. This study aimed to elucidate its mechanisms using an integrative approach. Methods: Constituents of LQYY were profiled by UPLC-MS/MS and integrated with network pharmacology and molecular docking to identify brain-accessible components and putative targets. A chronic unpredictable mild stress (CUMS) model was used for experimental validation. Outcomes included behavioral tests (sucrose preference test, open field test, and forced swimming test), gastrointestinal indices, including fecal water content, time of first black stool, and intestinal propulsion rate, histopathology of the prefrontal cortex (PFC) and colon, TUNEL staining, NeuN immunofluorescence, Western blotting, and qRT-PCR. Results: LQYY attenuated CUMS-induced weight loss and depressive-like behaviors and improved intestinal transit metrics. It reduced neuronal apoptosis in the PFC and ameliorated colonic injury. Mechanistically, docking and enrichment analyses highlighted hub targets (STAT3, AKT1, ESR1, IL-6, TNF, TP53) and the JAK/STAT pathway. In vivo, LQYY decreased IL-6, TNF-α, ESR1, TP53, and STAT3, and increased AKT1 in the PFC and colon; it also reduced the TUNEL-positive rate and restored NeuN labeling, upregulated Bcl-2, and downregulated p-JAK2/JAK2 and p-STAT3/STAT3 ratios, and the expression of Bax and cleaved-caspase-3 in the PFC, consistent with the suppression of pro-inflammatory and apoptotic signaling. Conclusions: LQYY exerts antidepressant and pro-motility effects in CUMS mice by modulating JAK2/STAT3-centered networks and inhibiting neuronal apoptosis, thus supporting a multi-component, multi-target strategy for treating depression with constipation, and providing a defined molecular hypothesis for future investigation. Full article

A metal-free multicomponent polymerization (MCP) method was developed for synthesizing sulfur-containing polythioamides, using elemental sulfur, dicarboxylic acids, and diamines as monomers. This approach offers a versatile strategy for producing polythioamides with excellent thermal stability and high mechanical strength. The synthesized polymers demonstrated a maximum Hg(II) adsorption capacity of 187 mg·g⁻¹, with adsorption efficiencies exceeding 90% for most polymers. Both aliphatic and aromatic polythioamides showed similar high adsorption performance, indicating the universal applicability of this synthesis method. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) confirmed the strong interaction between Hg(II) ions and the sulfur-containing thioamide groups. These results highlight the potential of MCP-based polythioamides as efficient adsorbents for mercury removal, with promising applications in environmental remediation. Full article

Sweeteners are commonly blended to exploit synergistic effects, enabling the desired sweetness to be attained while reducing total usage. However, establishing a quantitative relationship between mixed sweeteners’ concentration and sweetness intensity remains a key challenge. This study developed a sensory evaluation–machine learning approach to construct prediction models for binary/ternary mixtures of five sweeteners (sucrose, glucose, fructose, mannitol, and sorbitol). After feature selection of molecular descriptors and comparison of seven machine learning regression models, the Multilayer Perceptron achieved superior performance for the binary mixtures (R² = 0.9828), while the Support Vector Regression exhibited optimal performance for the ternary mixtures (R² = 0.9825). Concentration–sweetness intensity curves of mixed sweeteners at specific concentrations were generated using these two optimal prediction models. Results showed that at low concentrations, ternary blends of one sugar and two polyols (mannitol and sorbitol) exhibited stronger synergism than binary mixtures in the same concentration range. Specifically, blending the composite system of 1% mannitol and 2% sorbitol with 1% sucrose, 1% glucose, and 1% fructose separately increased the sweetness intensity by 39.6%, 42.8%, and 37.4%, respectively. This work confirms that machine learning can establish a quantitative relationship between multi-component sweeteners’ concentration and sweetness intensity, reveal their complex interactions, and provide a novel approach for intelligent sensory assessment and formulation design. Full article

Background/Objectives: Between 20 and 30% of the global population experiences Chronic Pain (CP). A comprehensive, interdisciplinary approach incorporating non-pharmacological interventions and active patient participation is recommended. This study evaluated the short- and medium-term effectiveness of a multicomponent workshop compared with a control group. Methods: A detailed description of the workshop and a single-group before–after evaluation in 197 patients were recently published. The present study used a quasi-experimental before–after design with a three-month follow-up, comparing an intervention group (n = 64) with a contemporaneous control group that continued with usual care (n = 64). Validated scales were used to measure pain, well-being, quality of life (QoL), self-esteem, resilience, anxiety, and depression. Two ad hoc surveys assessed satisfaction and perceived impact on pain, medication use, habits, and mood. Results: A total of 128 patients participated (64 per group). The intervention group showed statistically significant improvements in all indicators at both short-term (end of workshop) and medium-term (three months) follow-up. Pain decreased by −1.3 (−3.0–0) [3 months: −1.0 (−3.0–−1.0)], anxiety by −3.0 (−5.0–−1.0) [3 months: −3.0 (−5.0–1.0)], and depression by −4.0 (−7.0–−2.0) [3 months: −3.0 (−6.0–0)]. Well-being increased by 3.0 (1.0–4.0) [3 months: 1.0 (0–4.0)]; QoL by 0.213 (0.072–0.388) [3 months: 0.185 (0.013–0.337)]; perceived health by 13.5 (0–30.0) [3 months: 10.0 (0–30.0)]; self-esteem by 4.5 (1.0–7.3) [3 months: 3.0 (−1.0–6.0)], and resilience by 1.0 (−1.0–5.0) [3 months: 1.0 (0.0–5.0)]. In the control group, resilience worsened (−1.0 [−5.0–1.0], p = 0.002) and depression increased (1.0 [−1.0–3.0], p = 0.037). Pain decreased in 47 participants (74.6%) at the end of the workshop [3 months: 34 (65.4%)]. Of 55 who used medication, 48 (81.4%) reduced their intake [3 months: 34; 68.0%]. Healthy habits improved in 58 (92.1%) [3 months: 40; 78.4%]. Mood improved: 26 (41.3%) described themselves as “cheerful” and 24 (38.1%) as “neutral” [3 months: 23; 44.2% and 14; 26.9%]. Overall satisfaction: 9.7 (scale 0–10). Conclusions: The workshop enabled patients to mitigate pain, actively participate in self-care, and improve quality of life, self-esteem, and emotional well-being. These effects persisted three months post-intervention. Full article

X-ray crystallography remains the gold standard for high-resolution structural biology, yet obtaining diffraction-quality crystals continues to pose a major bottleneck due to inherently low success rates. This review advocates a paradigm shift from probabilistic screening to rational engineering, reframing crystallization as a controllable self-assembly process. We provide a comprehensive overview of strategies that connect fundamental physicochemical principles to practical applications, beginning with contact design, which involves the active engineering of crystal contacts through surface entropy reduction (SER), introduction of electrostatic patches. Complementing these molecular approaches, we discuss physicochemical strategies that exploit heterogeneous nucleation on functionalized surfaces and gold nanoparticles (AuNPs) to lower the energy barrier for crystal formation. We also address scaffold design, utilizing rigid fusion partners and polymer-forming chaperones to promote crystallization even from low-concentration solutions. Furthermore, we highlight principles for controlling the behavior of multi-component complexes, based on our experimental experience. Finally, we examine de novo lattice design, which leverages AI tools such as AlphaFold and RFdiffusion to program crystal lattices from first principles. Together, these strategies establish an integrated workflow that links thermodynamic stability with crystallizability. Full article

Indoor exposure to particulate matter (PM_2.5 and PM₁₀) remains a significant public health problem, especially in high-traffic areas, where outdoor pollution, building characteristics, and user activity jointly influence indoor air quality. This study aims to synthesise and compare the effectiveness of key technical solutions to reduce indoor PM concentrations in different types of buildings. A comprehensive review and comparative analysis of published experimental and field studies were conducted, covering residential, educational, office, medical, sports, and heritage buildings. The interventions evaluated included mechanical ventilation and filtration systems, portable HEPA air cleaners, integrated building envelope solutions, airflow optimisation strategies, and selected auxiliary technologies. Reported performance metrics such as baseline indoor and outdoor PM concentrations, air exchange rate (ACH), filter class, clean air delivery rate (CADR), and percentage reduction were systematically analysed. The results indicate that mechanical filtration, particularly high-efficiency HVAC (Heating Ventilation and Air-Conditioning) systems and HEPA filters, provide the most reliable and repeatable reductions in PM_2.5 and PM₁₀, especially under controlled airflow and recirculation conditions. Integrated approaches that combine airtight building envelopes, mechanical ventilation, and local air purification achieved the highest overall effectiveness. The findings confirm that successful PM mitigation requires context-specific multicomponent strategies tailored to building type, outdoor pollution load, occupancy, and ventilation design. Full article

To address clock drift arising from the absence of GPS synchronization during ocean-bottom seismic observations, we propose a time-offset correction and quality-control scheme that uses the correlation of P-wave empirical Green’s functions (EGFs) as the metric, and we demonstrate its efficacy in mitigating cross-correlation asymmetry caused by azimuthal noise in shallow-water environments. The method unifies the time delays of the four components into a single objective function, estimates per-node offsets via sparse weighted least squares with component-specific weights, applies spatial second-difference smoothing to suppress high-frequency oscillations, and performs spatiotemporally constrained regularized iterative optimization initialized by the previous day’s inversion to achieve a robust solution. Tests on a real four-component ocean-bottom node (4C-OBN) hydrocarbon exploration dataset show that, after conventional linear clock-drift correction of the OBN system, the proposed method can effectively detect millisecond-scale time jumps on individual nodes; compared with traditional noise cross-correlation time-shift calibration based on surface-wave symmetry, our four-component fusion approach achieves superior robustness and accuracy. The results demonstrate a marked increase in the coherence of the four-component cross-correlations after correction, providing a reliable temporal reference for subsequent multicomponent seismic processing and quality control. Full article