Search Results (24)

Background: The athletic potential of young athletes is shaped by individual and environmental factors. Objectives: This study examines the physical growth, body composition, biological maturation, motivation, perseverance, physical performance and contextual factors of young male and female track and field athletes. Methods: A total of 425 (224 girls) track and field athletes were recruited and divided into five age cohorts (10, 11, 12, 13, and 14 years respectively). Measurements were assessed across (i) individual (anthropometry, body composition, biological maturation, motivation, and perseverance), (ii) performance (motor performance), and (iii) club context domains. Data analysis used descriptive statistics for clubs’ characteristics, a two-factor ANOVA for anthropometry, body composition, biological maturation, and performance and an ANCOVA for motivation and perseverance. All analyses used STATA 18.0. Results: Sex-related differences were identified in physical growth, maturation, psychological, and performance variables during adolescence. Girls reached their peak height velocity (PHV) around 12 years of age, compared to 14 years in boys. At all ages (except at age 11), girls had higher body fat, and at age 12 were taller and outperformed boys in right-handgrip strength and in sprint (30 m and 40 m). From age 13 years onwards, boys became taller, with greater leg length, greater fat-free mass, and superior results (p < 0.05) in most performance tests. Psychologically, girls reported higher levels of interest–enjoyment, effort–importance, relatedness, and perceived choice; no sex differences were found in perseverance. The clubs involved were of small size, with developing, yet qualified, coaches, with limited support staff and infrastructure. Conclusions: Clear sex differences in physical growth, psychological, and performance variables emerged during adolescence, and were related in part to earlier maturation in girls. Further, there was variation in clubs’ infrastructure and staff that may potentially influence track and field athletes’ growth and development. Full article

Introduction: Virtual Reality (VR) training has potential evidence for reducing the risks of falls of older adults with mild cognitive impairment (MCI). There are indications of a positive training effect of a cognitive-motor intervention method to improve the postural balance and cognition for safer walking. This study aimed to evaluate the training effects of VR training for reducing the risks of falls among older adults with mild cognitive impairment (MCI). Methods: An experimental design was employed to evaluate how the participants attended a full-immersive VR Cave Automatic Virtual Environment (CAVE) training program. Fifty-five participants were randomly assigned to the VR group or the control group. The VR group received 16 training sessions over 8–10 weeks, while the control group received a non-VR falls prevention program. The primary outcome assessed any falls after the study, and the secondary outcomes assessed changes in cognition and executive function, walk speed and balance performances, and the psychological factor such as fear of falling relating to the risk factors of fall. Results: The VR group showed significantly greater improvement than the control group in terms of measures of cognitive-motor performance across group and time interaction. However, there were inconsistent results in functional mobility and fall efficacy between the two groups. Conclusion: This study provides promising evidence on the VR CAVE training for reducing the risks of falls among older adults with MCI from Hong Kong. VR technology-based applications are an emerging area in current aged care and rehabilitation services. Full article

This narrative review explores the significant evolution of sports rehabilitation, tracing its trajectory from basic exercise therapies of the early 20th century to the advanced, neuroplasticity-driven approaches of the 21st century, with a specific focus on anterior cruciate ligament reconstruction (ACLR). The primary aim is to understand how neuroplasticity, motor control, and sensorimotor retraining can optimize recovery, reduce reinjury risk, and enhance long-term athletic performance, and to synthesize current rehabilitation strategies that integrate innovative technologies, such as robotics, virtual reality (VR), and biofeedback systems, to address the neurocognitive deficits that contribute to the alarmingly high reinjury rates (9–29%) observed in young athletes post-ACLR. These deficits include impaired proprioception, motor control, and psychological factors like fear of reinjury. The methodology employed involves a narrative review of peer-reviewed literature from databases including PubMed, Scopus, and Web of Science. The synthesis of findings underscores the importance of holistic rehabilitation approaches, including targeted proprioceptive exercises, dual-task drills, and immersive VR training, in enhancing sensorimotor integration, decision-making, and athlete confidence. Furthermore, this review highlights the critical need for long-term monitoring and interdisciplinary collaboration between neuroscientists, physiotherapists, and engineers to refine rehabilitation protocols and ensure sustained recovery. By leveraging neuroplasticity and advanced technologies, the field can shift from a focus on purely physical restoration to comprehensive recovery models that significantly reduce reinjury risks and optimize athletic performance. Full article

This study explores the trends and causes of disengagement events in Autonomous Vehicles (AVs) using data from the California Department of Motor Vehicles (CA DMV) from 2019 to 2022. Disengagements, defined as instances where control transitions from the AV to a human driver, are crucial indicators of the reliability and trustworthiness of Autonomous Driving Systems (ADS). The analysis identifies a significant correlation between cumulative mileage and disengagement frequency, revealing that 77% of disengagements were initiated by safety drivers. The research categorizes disengagements into system-initiated, driver-initiated, or planned for testing purposes, highlighting that environmental factors and interactions with other road users are the primary causes attributed to the AV system. The findings indicate a downward trend in the ratio of disengagements to mileage, suggesting improvements in AV technology and increasing operator trust. However, the persistent rate of manual disengagements underscores ongoing challenges regarding driver confidence. This research enhances the understanding of ADS performance and driver interactions, offering valuable insights for improving AV safety and fostering technology acceptance in mixed-traffic environments. Future studies should prioritize enhancing system reliability and addressing the psychological factors that influence driver trust in ADS. Full article

Background: Traumatic brain injury (TBI) is a leading cause of mortality worldwide and often results in substantial cognitive, motor, and psychological impairments, triggering oxidative stress, neuroinflammation, and neurodegeneration. This study examined the neuroprotective effects of azithromycin (AZI) in TBI. Methods: TBI was induced in rats using the weight-drop method. Subsequently, rats received a daily intraperitoneal (I.P.) dose of AZI (150 mg/kg) for 28 days. Behavioral tests (Morris water maze, rotarod, and open field tests) were performed to assess cognitive and motor functions. Neurochemical analyses included oxidative stress markers (GSH, SOD, MDA, catalase), inflammatory cytokines (TNF-α, IL-1β), apoptotic markers (caspase-3, Bax, Bcl-2), mitochondrial complexes (complex I, II, III, IV, and V), and the transforming growth factor- beta (TGF-β) as a neurofilament marker. Histological evaluations focused on neuronal integrity in the cortex, hippocampus, and striatum. Results: Treatment with AZI significantly facilitated motor and cognitive function recovery in TBI-affected rats. At the molecular level, AZI effectively reduced oxidative stress markers, ameliorated neuroinflammation by decreasing TNF-α, IL-1β, and neuronal apoptosis, and differentially modulated mitochondrial complexes. Histological assessments revealed enhanced neuronal integrity and fewer pathological changes in AZI-treated rats compared to untreated TBI controls. Conclusions: AZI was shown to interfere with several pathways involved in TBI’s pathophysiology. While preclinical results are promising, further studies are necessary to establish the long-term safety and efficacy of AZI in a clinical setting. This research supports the potential re-purposing of AZI as a novel treatment strategy for TBI and related neurodegenerative disorders. Full article

The main objective was to perform a description of the potential biobehavioral factors that influence disability in patients with migraines and develop a multimodal physiotherapy treatment proposal incorporating therapeutic education and exercise prescription, applying a biobehavioral approach. This manuscript highlights the complex interplay between migraines and physical activity, with many migraine sufferers performing reduced physical activity, even during headache-free intervals. The kinesiophobia present in a significant portion of patients with migraine exacerbates functional disability and compromises quality of life. Psychological elements, especially pain catastrophizing, depression, and self-efficacy, further compound migraine-related disability. Addressing these issues requires a multidisciplinary approach that integrates physical activity and behavioral interventions. We propose a therapeutic education model of motor behavior that emphasizes the enhancement of therapeutic exercise outcomes. This model consists of the four following phases: (1) biobehavioral analysis of movement; (2) goal setting; (3) education about exercise benefits; and (4) movement education. A notable feature is the incorporation of motivational interviewing, a communication strategy that amplifies intrinsic motivation for change. Recent clinical guidelines have advocated for specific exercise modalities to ameliorate migraine symptoms. However, we highlight the importance of a tailored exercise prescription to maximize the benefits of exercise and reduce the possible adverse effects. The integration of exercise with other lifestyle recommendations, such as maintaining consistent sleep patterns and employing stress management techniques, is pivotal for improving outcomes in patients with migraine. Although evidence supports the benefits of these interventions in various painful conditions, further research is needed to establish their efficacy specifically for migraine management. Full article

Background: Impulsivity assessment may serve as a valuable clinical tool in the stratification of suicide risk. Acting without forethought is a crucial feature in the psychopathology of many psychiatric disturbances and corresponds with suicidal ideations, behaviors, and attempts. Methods: We present data on biological and psychological correlates of impulsivity among young adults (n = 47). Psychological analysis included both the self-description questionnaire—Barratt Impulsiveness Scale (BIS-11)—and neuropsychological behavioral tests, including the Iowa Gambling Task (IGT), the Simple Response Time task (SRT), and the Continuous Performance Test (CPT). mRNA and micro-RNA were isolated from peripheral blood mononuclear cells (PBMC). Expression levels of Brain-Derived Neurotrophic Factor (BDNF) mRNA and its regulatory micro RNAs, mir-1-3p, mir-15a-5p, mir-26a-5p, mir-26b-5p, and mir-195-5p, were analyzed using the quantitative reverse transcription polymerase chain reaction (RT-qPCR) method. proBDNF and BDNF plasma protein levels were quantified using enzyme-linked immunosorbent assay (ELISA). Results: Significant correlations between BDNF mRNA and mir-15a-5p as well as proBDNF levels and mir-1-3p were detected. proBDNF protein levels correlated with motor and perseverance, while mir-26b correlated with cognitive complexity subdimensions of the BIS-11 scale. Correlations between BDNF, miRNAs, and the results of neuropsychological tests were also detected. Conclusions: The BDNF pathway shows a clinical potential in searching for biomarkers of impulse-control impairment. BDNF-regulatory micro-RNAs are detectable and related to clinical parameters in the studied population, which needs further research. Full article

Technological advancement has propelled global economic growth, but it has also led to high rates of pollution emissions, underscoring the urgency of environmental issues. The transportation sector, particularly the rise in individual vehicle ownership, significantly contributes to atmospheric pollution. In this context, Brazil faces growing challenges, largely due to the high number of individual motor vehicles. Transitioning to electric vehicles (EVs) is seen as a sustainable alternative to reduce emissions of polluting gases. However, it is important to consider that EVs may indirectly generate pollution due to energy production in thermal power plants. Nevertheless, EVs are often sought by countries to reduce dependence on imported fuels and to mitigate urban pollution. This study aims to understand the factors influencing the purchase decision of EVs in Brazil through a systematic literature review and validation by specialists using the fuzzy Delphi method. The results indicate 37 variables, grouped into five main blocks: psychological factors, performance factors, environmental factors, barriers, and prospects for the automotive sector. The validation of these variables by specialists provides a solid foundation for the next stage of the research, which involves administering the questionnaire to the general community. Considering these results will lead to strategies aimed at promoting EV adoption, in line with global sustainability challenges and the reduction in CO₂ emissions. Full article

Sports injuries have historically been addressed and treated from a purely physical perspective. Nevertheless, like in many other aspects of sports, it has become evident during the last decades that psychological considerations and consequent interventions are both vital and inevitable in the work with athletes, particularly in the work with junior athletes. Especially in the domains of sports injury prevention and rehabilitation, psychological measures can yield significant benefits for junior athletes. Stress management techniques, cognitive restructuring, mindfulness, motor imagery, or seeking social support have been demonstrated as being highly effective. These techniques, many of them originally intended by sport psychologists to optimize performance, now aid junior athletes in performing at their best while also preventing injury and facilitating a safe return to competition after injury. During injury rehabilitation, sport psychological measures play an important role as well. The purpose of this review is firstly to provide an overview of the psychological factors that significantly support both injury prevention and rehabilitation. We subsequently elaborate on the identification and optimization of these factors by presenting evidence-based psychological interventions and training programs. In addition, we provide science-informed fundamentals that may serve as a basis for the adaptation and/or development of novel psychological measures to support junior athletes during injury prevention and rehabilitation. Full article

Eating behaviour (EB) is a complex system affected by different factors, including food liking and psychology. Researchers have highlighted the importance of genetics in EB, but little is known. Therefore, this study aimed to investigate the genetic factors involved in EB in Italian cohorts, Friuli-Venezia Giulia (FVG) and Val Borbera (VB). Genome-Wide Association Studies (GWAS) on food liking were performed in FVG (n = 575). The relationships between the genetic findings and other variables of interest (i.e., psychological outcomes) were evaluated using linear regression models. A replication study was carried out in an independent cohort (VB, n = 701). GWAS revealed a significant association between the liking of milk chocolate and a region on chromosome 5. The most associated single nucleotide polymorphism (SNP) was rs73280705 (p = 1.02 × 10⁻⁹), an eQTL for the LARP1 gene in the nucleus accumbens (NAc). Subjects carrying the minor allele of the SNP show a reduced liking for milk chocolate, as well as a minor overall liking for a milk-based food group. The latter finding was replicated in VB (p = 0.026). Regarding the psychological data, these subjects also present a reduced impulsivity (p = 0.031). On the other hand, carriers of the counterpart allele show an increased liking for milk-based food and a high impulsivity (p = 0.023). These data are not influenced by the lactose deficiency allele. The results suggest that this genetic region could play a role in both impulsivity and food liking. Indeed, individuals carrying the LARP1 gene variant show a decrease in liking for milk chocolate and milk-based food, as well as in impulsivity, while the others are more impulsive, like more milk-based foods and, in general, sweet and fatty foods. LARP1 is expressed in the NAc, which is a central driver of reward response controlling the pleasantness and gratification given by food (mostly triggered by highly palatable foods). Moreover, the NAc also plays a role in integrating limbic system stimulation into the motor system, which can lead to addictive and impulsive behaviours. Additional studies are needed to increase our knowledge on this extremely interesting gene association and, overall, on the LARP1 gene’s relationship with milk and mTORC1, food liking, and EB. Full article

Background: Patients with age-related white matter changes (ARWMC) frequently present a gait disorder, depression and cognitive impairment. Our aims are to define which alterations in the gait parameters are associated with motor or neuro-psychological impairment and to assess the role of motor, mood or cognitive dysfunction in explaining the variance of the gait parameters. Methods: Patients with gait disorders admitted to a Neuro-rehabilitation Department, affected by vascular leukoencephalopathy who had ARWMC confirmed by a brain MRI, were consecutively enrolled, classified by a neuroradiological scale (Fazekas 1987) and compared to healthy controls. We excluded subjects unable to walk independently, subjects with hydrocephalus or severe aphasia, with orthopaedic and other neurological pathologies conditioning the walking pattern. Patients and controls were assessed by clinical and functional scales (Mini Mental State Examination, Geriatric Depression Scale, Nevitt Motor Performance Scale, Berg Balance Scale, Functional Independence Measure), and computerised gait analysis was performed to assess the spatial and temporal gait parameters in a cross-sectional study. Results: We recruited 76 patients (48 males, aged 78.3 ± 6.2 years) and 14 controls (6 males, aged 75.8 ± 5 years). In the multiple regression analysis, the gait parameter with overall best model summary values, associated with the ARWMC severity, was the stride length even after correction for age, sex, weight and height (R² = 0.327). The motor performances justified at least in part of the gait disorder (R² change = 0.220), but the mood state accounted independently for gait alterations (R² change = 0.039). The increase in ARWMC severity, the reduction of motor performance and a depressed mood state were associated with a reduction of stride length (R = 0.766, R² = 0.587), reduction of gait speed (R² = 0.573) and an increase in double support time (R² = 0.421). Conclusion: The gait disorders in patients with ARWMC are related to motor impairment, but the presence of depression is an independent factor for determining gait alterations and functional status. These data pave the way for longitudinal studies, including gait parameters, to quantitatively assess gait changes after treatment or to monitor the natural progression of the gait disorders. Full article

Variation during practice is widely accepted to be advantageous for motor learning and is, therefore, a valuable strategy to effectively reduce high-risk landing mechanics and prevent primary anterior cruciate ligament (ACL) injury. Few attempts have examined the specific effects of variable training in athletes who have undergone ACL reconstruction. Thereby, it is still unclear to what extent the variations in different sensor areas lead to different effects. Accordingly, we compared the effects of versatile movement variations (DL) with variations of movements with emphasis on disrupting visual information (VMT) in athletes who had undergone ACL reconstruction. Forty-five interceptive sports athletes after ACL reconstruction were randomly allocated to a DL group (n = 15), VT group (n = 15), or control group (n = 15). The primary outcome was functional performance (Triple Hop Test). The secondary outcomes included dynamic balance (Star Excursion Balance Test (SEBT)), biomechanics during single-leg drop-landing task hip flexion (HF), knee flexion (KF), ankle dorsiflexion (AD), knee valgus (KV), and vertical ground reaction force (VGRF), and kinesiophobia (Tampa Scale of Kinesiophobia (TSK)) assessed before and after the 8 weeks of interventions. Data were analyzed by means of 3 × 2 repeated measures ANOVA followed by post hoc comparison (Bonferroni) at the significance level of p ≤ 0.05. Significant group × time interaction effects, main effect of time, and main effect of group were found for the triple hop test and all eight directions, SEBT, HF, KF, AD, KV, VGRF, and TSK. There was no significant main effect of group in the HF and triple hop test. Additionally, significant differences in the triple hop test and the seven directions of SEBT, HF, KF, KV, VGRF, and TSK were found between the control group and the DL and VMT groups. Between group differences in AD and the medial direction of SEBT were not significant. Additionally, there were no significant differences between VMT and the control group in the triple hop test and HF variables. Both motor learning (DL and VMT) programs improved outcomes in patients after ACL reconstruction. The findings suggest that DL and VMT training programs lead to comparable improvements in rehabilitation. Full article

Future missions to Mars will expose astronauts to several physical and psychological challenges, including exposure to space radiation (SR) and periods of social isolation (SI). Each of these stressors, in addition to mission demands, can affect physical and mental health and potentially negatively impact sleep. The effects of inflight stressors may vary with duration and time course, may be additive or compounding, and may vary with individual differences in stress resilience and vulnerability. Determining how individual differences in resilient and vulnerable phenotypes respond to these mission-related stressors and their interactions with sleep will be crucial for understanding and mitigating factors that can impair performance and damage health. Here, we examined the single and compound effects of ground-based analogs of SI and SR on sensorimotor performance on the balance beam (BB) in rats. We also assessed emotional responses during testing on the BB and assessed whether sensorimotor performance and emotion varied with individual differences in stress resiliency using our established animal model in which stress produces different effects on sleep. Results showed differential motor performance and emotion in the BB task between SI and SR, and these varied based on resilient and vulnerable phenotypes. These findings demonstrate that identifying individual responses to stressors that can impact sensorimotor ability and behavior necessary to perform mission-related tasks will be of particular importance for astronauts and future missions. Should similar effects occur in humans, there may be considerable inter-individual variability in the impact that flight stressors have on the mental health of astronauts and their ability to perform mission-related tasks. Full article

The heterogeneity of symptoms in young patients with major depression disorder makes it difficult to properly identify and diagnose. Therefore, the appropriate evaluation of mood symptoms is important in early intervention. The aim of this study was to (a) establish dimensions of the Hamilton Depression Rating Scale (HDRS-17) in adolescents and young adults and (b) perform correlations between the identified dimensions and psychological variables (impulsivity, personality traits). This study enrolled 52 young patients with major depression disorder (MDD). The severity of the depressive symptoms was established using the HDRS-17. The factor structure of the scale was studied using the principal component analysis (PCA) with varimax rotation. The patients completed the self-reported Barratt Impulsiveness Scale (BIS-11) and Temperament and Character Inventory (TCI). The three dimensions of the HDRS-17 identified as core in adolescent and young patients with MDD were (1) psychic depression/motor retardation, (2) disturbed thinking, and (3) sleep disturbances/anxiety. In our study, dimension 1 correlated with reward dependence and cooperativeness; dimension 2 correlated with non-planning impulsivity, harm avoidance, and self-directedness; and dimension 3 correlated with reward dependence. Conclusions: Our study supports the previous findings, which indicate that a certain set of clinical features (including the HDRS-17 dimensions, not only total score) may represent a vulnerability pattern that characterizes patients with depression. Full article

Non-specific chronic low back pain (NSCLBP) is defined as a complex disorder involving structural, biomechanical, cognitive, psychological, social, and lifestyle factors. Non-pharmacological approaches such as exercise and physical therapy have been proposed in first-line treatments, along with psychological follow-up and pain medication if needed. Our objective was to evaluate the effectiveness of an intensive rehabilitation program with HUBER (a multi-axis motorized platform equipped with force sensors, allowing patients to perform physical exercises in an isometric mode) on the spine flexion-to-extension ratio at 60 and 120°/s, pain, and trunk flexibility in individuals with NSCLBP. Twelve participants underwent a clinical evaluation including isokinetic spine strength and participated in a 6-week rehabilitation program with HUBER 360 Evolution. The main findings of this pilot study show that the flexor/extensor ratios at 60°, the flexibility of the hamstring and quadriceps, and muscular endurance of the trunk, disability, and quality of life were significantly improved at the end of the rehabilitation program (p < 0.05). Low back pain and analgesic medication were also reduced. Exercising with the HUBER Platform seems to be effective in managing NSCLBP but a randomized study with a larger sample size and a control group is necessary. Full article