Search Results (2,878)

Motor Neuron Diseases (MNDs) such as Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Spinal Muscular Atrophy with Respiratory Distress Type 1 (SMARD1), Multisystem Proteinopathy (MSP), Spinal and Bulbar Muscular Atrophy (SBMA), and ALS associated to Frontotemporal Dementia (ALS-FTD), have traditionally been studied as distinct entities, each one with unique genetic and clinical characteristics. However, emerging research reveals that these seemingly disparate conditions converge on shared molecular mechanisms that drive progressive neuroaxonal degeneration. This narrative review addresses a critical gap in the field by synthesizing the most recent findings into a comprehensive, cross-disease mechanisms framework. By integrating insights into RNA dysregulation, protein misfolding, mitochondrial dysfunction, DNA damage, kinase signaling, axonal transport failure, and immune activation, we highlight how these converging pathways create a common pathogenic landscape across MNDs. Importantly, this perspective not only reframes MNDs as interconnected neurodegenerative models but also identifies shared therapeutic targets and emerging strategies, including antisense oligonucleotides, autophagy modulators, kinase inhibitors, and immunotherapies that transcend individual disease boundaries. The diagnostic and prognostic potential of Neurofilament Light Chain (NfL) biomarkers is also emphasized. By shifting focus from gene-specific to mechanism-based approaches, this paper offers a much-needed roadmap for advancing both research and clinical management in MNDs, paving the way for cross-disease therapeutic innovations. Full article

This paper presents an electromechanical coupling model integrating an equivalent magnetic network (EMN) model of a dual three-phase permanent magnet synchronous motor (DTP-PMSM) with the dynamic model of a helical planetary gear transmission system. Using this model, this study analyzes the dynamic characteristics of an electric drive system, specifically motor phase current, electromagnetic torque, and gear meshing force, under self-fault-tolerant control strategies. Simulation and experimental results demonstrate that the self-fault-tolerant control strategy enables rapid fault tolerance during open-phase faults, significantly reducing system fault recovery time. Meanwhile, compared to the open-phase faults conditions, the self-fault-tolerant control effectively suppresses most harmonic components within the system; only the second harmonic amplitude of the electromagnetic torque exhibited an increase. This harmonic disturbance propagates to the gear system through electromechanical coupling, synchronously amplifying the second harmonic amplitude in the gear system’s vibration response. This study demonstrates that self-fault-tolerant control strategies significantly enhance the dynamic response performance of the electric drive system under open-phase faults conditions. Furthermore, this study also investigates the electromechanical coupling mechanism through which harmonics generated by this strategy affect the gear system’s dynamic response, providing theoretical support for co-optimization electromechanical coupling design and fault-tolerant control in high-reliability electric drive transmission systems. Full article

Electric motors play a decisive role in electric vehicles by converting electrical energy into mechanical motion across various drivetrain components. However, failures in these motors can interrupt the motor function, with approximately 40% of these failures stemming from bearing issues. Key contributors to bearing degradation include shaft voltage, bearing current, and electric discharge material spalling current, especially in motors powered by inverters or variable frequency drives. This review explores the tribological and vibrational aspects of bearing currents, analyzing their mechanisms and influence on electric motor performance. It addresses the challenges faced by electric vehicles, such as high-speed operation, elevated temperatures, electrical conductivity, and energy efficiency. This study investigates the origins of bearing currents, damage linked to shaft voltage and electric discharge material spalling current, and the effects of lubricant properties on bearing functionality. Moreover, it covers various methods for measuring shaft voltage and bearing current, as well as strategies to alleviate the adverse impacts of bearing currents. This comprehensive analysis aims to shed light on the detrimental effects of bearing currents on the performance and lifespan of electric motors in electric vehicles, emphasizing the importance of tribological considerations for reliable operation and durability. The aim of this study is to address the engineering problem of bearing failure in inverter-fed EV motors by integrating electrical, tribological, and lubrication perspectives. The novelty lies in proposing a conceptual link between lubricant breakdown and damage morphology to guide mitigation strategies. The study tasks include literature review, analysis of bearing current mechanisms and diagnostics, and identification of technological trends. The findings provide insights into lubricant properties and diagnostic approaches that can support industrial solutions. Full article

The growing need for high-efficiency and reliable propulsion systems in naval applications, particularly within the evolving landscape of submarine warfare, has led to an increased interest in multiphase Permanent Magnet AC motors. This study presents a modelling and simulation approach for a 3MW, seventeen-phase Permanent Magnet AC motor designed for submarine propulsion, integrating an AI-based drive control system. Despite the advantages of multiphase motors, such as higher power density and enhanced fault tolerance, significant challenges remain in achieving precise torque and variable speed, especially for externally mounted motors operating under deep-sea conditions. Existing control strategies often struggle with the inherent nonlinearities, unmodelled dynamics, and extreme environmental variations (e.g., pressure, temperature affecting oil viscosity and motor parameters) characteristic of such demanding deep-sea applications, leading to suboptimal performance and compromised reliability. Addressing this gap, this research investigates advanced control methodologies to enhance the performance of such motors. A MATLAB/Simulink framework was developed to model the motor, whose drive system leverages an AI-optimised dual fuzzy-PID controller refined using the Harmony Search Algorithm. Additionally, a combination of Indirect Field-Oriented Control (IFOC) and Space Vector PWM strategies are implemented to optimise inverter switching sequences for precise output modulation. Simulation results demonstrate significant improvements in torque response and control accuracy, validating the efficacy of the proposed system. The results highlight the role of AI-based propulsion systems in revolutionising submarine manoeuvrability and energy efficiency. In particular, during a test case involving a speed transition from 75 RPM to 900 RPM, the proposed AI-based controller achieves a near-zero overshoot compared to an initial control scheme that exhibits 75.89% overshoot. Full article

The study of vibration characteristics and suppression methods in integrated electric drive systems of electric vehicles is of critical importance. To investigate these characteristics, both current harmonics within the motor and nonlinear factors within the drivetrain were considered. A 17-degree-of-freedom nonlinear torsional–planar dynamic model was developed, with electromagnetic torque and output speed as coupling terms. The model’s accuracy was experimentally validated, and the system’s dynamic responses were analyzed under different working conditions. To mitigate vibrations caused by torque ripple, a coordinated control strategy was proposed, combining a quasi-proportional multi-resonant (QPMR) controller and a full-frequency harmonic controller (FFHC). The results demonstrate that the proposed strategy effectively suppresses multi-order current harmonics in the driving motor, reduces torque ripple by 45.1%, and enhances transmission stability. In addition, the proposed electromechanical coupling model provides valuable guidance for the analysis of integrated electric drive systems. Full article

This paper presents an advanced energy management system (EMS) for optimizing power distribution in a battery/ultracapacitor (UC) hybrid energy storage system (HESS) for electric vehicles (EVs). The proposed EMS accounts for all energy flow scenarios within a practical driving cycle. A regenerative braking control strategy is developed to maximize kinetic energy recovery using an induction motor, efficiently distributing the recovered energy between the UC and battery. Additionally, a power flow management approach is introduced for both motoring (discharge) and braking (charge) operations via bidirectional buck–boost DC-DC converters. In discharge mode, an optimal distribution factor is dynamically adjusted to balance power delivery between the battery and UC, maximizing efficiency. During charging, a DC link voltage control mechanism prioritizes UC charging over the battery, reducing stress and enhancing energy recovery efficiency. The proposed EMS is validated through simulations and experiments, demonstrating significant improvements in vehicle acceleration, energy efficiency, and battery lifespan. Full article

With the electrification of generator sets, electric locomotives, new energy vehicles, and other industries, AC motors subject bearings to an electric field environment, leading to galvanic corrosion due to the use of variable frequency power supply drives. The phenomenon of bearing discharge breakdown in subway traction motors is a critical issue in understanding the relationship between shaft current strength and the extent of bearing damage. This paper analyzes the mechanism of impulse discharge that leads to galvanic corrosion damage in bearings at a microscopic level and conducts electric thermal coupling simulations of the traction motor bearing discharge breakdown process. It examines the temperature rise associated with lubricant film discharge breakdown during the dynamic operation of the bearing and investigates how breakdown channel parameters and operational conditions affect the temperature rise in the micro-region of bearing lubrication. Ultimately, the results of the electric thermal coupling simulation are validated through experimental tests. This study revealed that in an electric field environment, the load-bearing area of the outer ring experiences significantly more severe corrosion damage than the inner ring, whereas non-bearing areas remain unaffected by electrolytic corrosion. When the inner ring reaches a speed of 4500_rpm, the maximum widths of electrolytic corrosion pits for the outer and inner rings are measured at 89 um and 51 um, respectively. Additionally, the highest recorded temperatures for the breakdown channels in the outer and inner rings are 932 °C and 802 °C, respectively. Furthermore, as the inner ring speed increases, both the width of the electrolytic corrosion pits and the temperature of the breakdown channels rise. Specifically, at inner ring speeds of 2500_rpm, 3500_rpm, and 4500_rpm, the widths of the electrolytic pits in the outer ring raceway load zone were measured at 34 um, 56 um, and 89 um, respectively. The highest temperatures of the lubrication film breakdown channels were recorded as 612 °C, 788 °C, and 932 °C, respectively. This study provides a theoretical basis and data support for the protective and maintenance practices of traction motor bearings. Full article

This article presents a comparative study of the storage of energy produced by photovoltaic panels by means of two types of batteries: Lead–Acid and Lithium-Ion batteries. The work involved the construction of a model in MATLAB-Simulink for controlling the loading/unloading of storage batteries with energy produced by photovoltaic panels through a buck-type DC-DC convertor, controlled by means of the MPPT algorithm implemented through the method of incremental conductance based on a MATLAB function. The program for the MATLAB function was developed by the author in the C++ programming environment. The MPPT algorithm provides maximum energy transfer from the photovoltaic panels to the battery. The electric power taken over at a certain moment by Lithium-Ion batteries in photovoltaic panels is higher than the electric power taken over by Lead–Acid batteries. Two types of batteries were successively used in this model: Lead–Acid and Lithium-Ion batteries. Based on the results being obtained and presented in this work it may be affirmed that the storage battery Lithium-Ion is more performant than the Lead-Acid storage battery. At the Laboratory of Electrical Machinery and Drives of the Engineering Faculty of Bacau, an experimental stand was built for a storing system for electric energy produced by photovoltaic panels. For controlling DC-DC buck-type convertors, a program was developed in the programming environment Arduino IDE for implementing the MPPT algorithm for incremental conductance. The simulation part of this program is similar to that of the program developed in C++. Through conducting experiments, it was observed that, during battery charging, along with an increase in the charging voltage, an increase in the filling factor of the PWM signal controlling the buck DC-DC convertor also occurred. The findings of this study may be applicable to the storage of battery-generated electrical energy used for supplying electrical motors in electric cars. Full article

The detection of proteins plays a key role in disease diagnosis and drug development. For this, we numerically investigated a novel microfluidic motor actuated by an induced-charge electro-osmotic (ICEO) whirling flow. An alternating current–flow field effect transistor is engineered to modulate the profiles of ICEO streaming to stimulate and adjust the whirling flow in the circle microfluidic chamber. Based on this, we studied the distribution of an ICEO whirling flow in the detection chamber by tuning the fixed potential on the gate electrodes by the simulations. Then, we established a fluid–structure interaction model to explore the influence of blade structure parameters on the rotation performance of microfluidic motors. In addition, we investigated the rotation dependence of microfluidic motors on the potential drop between two driving electrodes and fixed potential on the gate electrodes. Next, we numerically explored the capability of these microfluidic motors for the detection of low-abundance proteins. Finally, we studied the regulating effect of potential drops between the driving electrodes on the detection performance of microfluidic motors by numerical simulations. Microfluidic motors actuated by an ICEO whirling flow hold good potential in environmental monitoring and disease diagnosis for the outstanding advantages of flexible controllability, a simple structure, and gentle work condition. Full article

To improve the stability and safety of electric vehicles during medium-to-high-speed cornering, this paper investigates torque differential control for dual rear-wheel hub motor drive systems, extending beyond traditional speed control based on the Ackermann steering model. A nonlinear three-degree-of-freedom vehicle dynamics model incorporating the Dugoff tire model was established. By introducing the maximum correntropy criterion, an unscented Kalman filter was developed to estimate longitudinal velocity, sideslip angle at the center of mass, and yaw rate. Building upon the speed differential control achieved through Ackermann steering model-based rear-wheel speed calculation, improvements were made to the conventional exponential reaching law, while a novel switching function was proposed to formulate a new sliding mode controller for computing an additional yaw moment to realize torque differential control. Finally, simulations conducted on the Carsim/Simulink platform demonstrated that the maximum correntropy criterion unscented Kalman filter effectively improves estimation accuracy, achieving at least a 22.00% reduction in RMSE metrics compared to conventional unscented Kalman filter. With torque control exhibiting higher vehicle stability than speed control, the RMSE values of yaw rate and sideslip angle at the center of mass are reduced by at least 20.00% and 4.55%, respectively, enabling stable operation during medium-to-high-speed cornering conditions. Full article

Aiming at the multifunctional requirements of the limited space in high-end vehicle side-door latches, a double single-loop RRUPRR mechanism driven by a single motor for both electric releasing and cinching is proposed based on the POC set. The kinematical equations of the RRURR mechanism possess 2 × 2 analytical solutions. In order to apply the current motion/force transmission performance index of the parallel mechanisms to the transmission performance analysis of the serial mechanisms, matching methods for chain-driving transference and the moving/fixed platform inversion are proposed. The solution of the performance index of a single-degree-of-freedom single-loop mechanism is equivalent to the solution of the input motion/force transmission performance index of a parallel mechanism. The overall motion/force transmission performance index of a single-loop mechanism is constructed, and the corresponding calculation procedure is defined. Chain-driving transference can be obtained through forward and inverse solutions of the RRURR mechanism. In response to the extremely high requirements for motion/force transmission performance of electric release mechanisms, the proposed overall motion/force transmission performance index is used to calculate for the input motion screw and corresponding transmission-force screw of the single-loop RRURR mechanism and obtain the overall motion/force transmission performance of the mechanism. The performance atlas of the mechanism shows that it has excellent motion/force transmission characteristics within the workspace. Using ADAMS simulation software, the driving torque required for electric releasing and cinching of a vehicle side-door latch mechanism with a single motor is analyzed. The overall motion/force transmission performance index of a single-loop mechanism can be applied to single-loop overconstrained mechanisms and non-overconstrained mechanisms. Full article

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major global health challenge characterized by complex adipose–liver interactions mediated by adipokines and hepatokines. Despite rapid field evolution, a comprehensive understanding of research trends and translational advances remains fragmented. This study systematically maps the scientific landscape through bibliometric analysis, identifying emerging domains and future clinical translation directions. Methods: A comprehensive bibliometric analysis of 1002 publications from 2004 to 2025 was performed using thematic mapping, temporal trend evaluation, and network analysis. Analysis included geographical and institutional distributions, thematic cluster identification, and research paradigm evolution assessment, focusing specifically on adipokine–hepatokine signaling mechanisms and clinical implications. Results: The United States and China are at the forefront of research output, whereas European institutions significantly contribute to mechanistic discoveries. The thematic map analysis reveals the motor/basic themes residing at the heart of the field, such as insulin resistance, fatty liver, metabolic syndrome, steatosis, fetuin-A, and other related factors that drive innovation. Basic clusters include metabolic foundations (obesity, adipose tissue, FGF21) and adipokine-centered subjects (adiponectin, leptin, NASH). New themes focus on inflammation, oxidative stress, gut microbiota, lipid metabolism, and hepatic stellate cells. Niche areas show targeted fronts such as exercise therapies, pediatric/novel adipokines (chemerin, vaspin, omentin-1), and advanced molecular processes that focus on AMPK and endoplasmic-reticulum stress. Temporal analysis shows a shift from single liver studies to whole models that include the gut microbiota, mitochondrial dysfunction, and interactions between other metabolic systems. The network analysis identifies nine major clusters: cardiovascular–metabolic links, adipokine–inflammatory pathways, hepatokine control, and new therapeutic domains such as microbiome interventions and cellular stress responses. Conclusions: In summary, this study delineates current trends and emerging areas within the field and elucidates connections between mechanistic research and clinical translation to provide guidance for future research and development in this rapidly evolving area. Full article

Underwater propulsion systems are the fundamental functional modules of underwater robotics and are crucial in intricate underwater operational scenarios. This paper proposes a biomimetic underwater robot propulsion scheme that is motivated by the hindlimb movements of the bullfrog. A multi-linkage mechanism was developed to replicate the “kicking-and-retracting” motion of the bullfrog by employing motion capture systems to acquire biological data on their hindlimb movements. The FDM 3D printing and PC board engraving techniques were employed to construct the experimental prototype. The prototype’s biomimetic and motion characteristics were validated through motion capture experiments and comparisons with a real bullfrog. The biomimetic bullfrog hindlimb propulsion system was tested with six-degree-of-freedom force experiments to evaluate its propulsion capabilities. The system achieved an average thrust of 2.65 N. The effectiveness of motor drive parameter optimization was validated by voltage comparison experiments, which demonstrated a nonlinear increase in thrust as voltage increased. This design approach, which transforms biological kinematic characteristics into mechanical drive parameters, exhibits excellent feasibility and efficacy, offering a novel solution and quantitative reference for underwater robot design. Full article

AAA+ ATPases are ring-shaped hexameric protein complexes that operate as elaborate macromolecular motors, driving a variety of ATP-dependent cellular processes. AAA+ ATPases undergo large-scale conformational changes that lead to the conversion of chemical energy from ATP into mechanical work to perform a wide range of functions, such as unfolding and translocation of the protein substrate inside a proteolysis chamber of an AAA+-associated protease. Despite extensive biochemical studies on these macromolecular assemblies, the mechanism of substrate unfolding and degradation has long remained elusive. Indeed, until recently, structural characterization of AAA+ protease complexes remained hampered by the size and complexity of the machinery, harboring multiple protein subunits acting together to process proteins to be degraded. Additionally, the major structural rearrangements involved in the mechanism of this complex represent a crucial challenge for structural biology. Here, we report the main advances in deciphering molecular details of the proteolytic reaction performed by AAA+ proteases, based on the remarkable progress in structural biology techniques. Particular emphasis is placed on the latest findings from high-resolution structural analysis of the ClpXP proteolytic complex, using crystallographic and cryo-EM investigations. In addition, this review presents some additional dynamic information obtained using solution-state NMR. This information provides molecular details that help to explain the protein degradation process by such molecular machines. Full article

The dynamics of the vibrational mode of motion of the driving member of a nonideal system, a mixing–whipping device based on a simple slide-crank mechanism, was studied. The highly nonlinear differential equations of motion were solved numerically by the Runge–Kutta method. The interaction of the mixing–whipping device with the nonideal excitation source causes the rotational speed of the engine shaft and the rotation angle of the driving member to fluctuate, accomplishing a damped process. The parameters of the device and the nonideal energy source have an effect on the kinematic, vibrational and energy characteristics of the system. An increase in the engine’s torque, crank length, number and radius of piston holes, and piston mass, as well as a decrease in the fluid’s density, leads to a reduction in the oscillation range of the crank angle, amplitude and period of angular velocity oscillations of the engine shaft and the mixing–whipping force power. The effects of a nonideal energy source may be used in designing a mixing–whipping device based on a slider-crank mechanism to select effective system parameters and an energy-saving motor in accordance with the requirements of technological processes and products. Full article