Search Results (474)

Fluoride remains the keystone of evidence-based caries prevention by stabilizing the mineral balance at the tooth–biofilm–saliva interface. Contemporary understanding emphasizes a predominantly post-eruptive, topical mode of action where fluoride inhibits demineralization and accelerates remineralization. This interfacial catalysis is reinforced by pH-responsive calcium-fluoride-like reservoirs that release fluoride during acid challenges. While community water fluoridation confers population-level reductions, the most effective approach is sustaining low-level fluoride in the biofilm environment. Evidence confirms that toothpastes with 1000–1500 ppm fluoride provide a dose–response benefit in children, while 5000 ppm concentrations are indicated for high-risk scenarios such as root caries and xerostomia. Beyond physicochemical effects, fluoride modulates the oral microbiome by inhibiting bacterial enzymes and proton pumps, shifting community function toward a health-associated state without reducing overall diversity. In restorative dentistry, glass ionomer cements offer superior preventive effects against secondary caries compared to amalgam; however, marginal integrity, adhesive performance, and clinical technique, rather than fluoride release alone, remain the primary determinants of success. Despite well-known risks associated with high systemic intake, such as fluorosis, current evidence does not indicate genotoxic or adverse microbiome effects in humans from routine topical use of standard fluoride products at recommended preventive concentrations. Overall, fluoride’s cariostatic value rests on frequent, low-level exposures that maintain tissues in a repair-favoring state. Full article

The Porous Line is a drawing inquiry that uses materials and processes to engage in a dialogue with a suburban ecosystem. I follow the physicist David Bohm’s proposal to use dialogue as a mode of engagement where habitual modes of thought are suspended, a form of non-judgmental curiosity. I reflect on how immersing a large roll of French imported paper in my everyday environs reveals the porousness between nature and culture. The binary separation of nature and culture has undergone significant criticism as we deal with the climate crisis. As a foundational medium within western art and thought, how can drawing communicate this growing ontological shift? The essay engages in dialogue with Yolngu art from Yirrkala as a guide on what an ecological art practice entails. Their commitment to work with what ‘country’ provides has resulted in innovative and thoughtful new works. In response to propositions seen in Yolngu artworks, this essay engages with place, materiality, and relationality through the process of merging line and ground, the fundamentals of drawing, physically and conceptually. I reflect on the challenges that need to be addressed within western ontologies to develop an ecological approach in drawing. Full article

Multirotor unmanned aerial vehicles (UAVs) rely on electronic speed controllers (ESCs) that decode motor commands from pulse-width modulation (PWM) signals, making the flight-controller-to-ESC command path a physical-layer attack surface for intentional electromagnetic interference (IEMI). This paper presents a mechanism-based analysis of IEMI attacks that induce motor stoppage in UAV brushless DC motor controllers. We develop a timing-error model in which a sinusoidal disturbance on the PWM line shifts the detected edge instants and drives the decoded pulse width into stop-equivalent regimes, and we show that the disturbance reaching the ESC’s thresholding node is shaped by a frequency-selective cascade of the PWM cable’s coupling response and the ESC’s input-path transfer function. We experimentally characterize this model on five commercial ESCs through conducted and radiated injection. The measured thresholds differ by more than an order of magnitude across ESCs and are reordered between frequency bands and injection modes; comparing conducted and radiated results allows us to attribute these differences primarily to the cable coupling response and reveals cases where it either hides or amplifies an ESC’s susceptibility. The susceptible frequency also shifts with PWM cable length in qualitative agreement with transmission-line resonance, confirming that observed radiated susceptibility reflects the joint design of ESC and cable rather than a single intrinsic property. The cable lengths examined here (45–125 cm) are longer than those of compact multirotors and were chosen to place resonances within our antenna’s band; we discuss the implications of this choice and identify shorter, deployment-realistic cables as a priority for future work. Full article

While action video games (AVGs) can enhance cognitive control, mechanisms underlying gaming disorder (GD) remain unclear. Using the Dual Mechanisms of Control framework, two task-switching experiments dissociated proactive and reactive control among AVG players with GD, recreational game users (RGU), and non-gamers (NG). Experiment 1 provided initial evidence that, unlike healthy controls, GD players showed difficulty sustaining proactive preparation over extended intervals and tended to rely more on post-response interference resolution. Experiment 2 further supported this reactive dependence: after prolonged delays, switch costs in the GD group dropped to negligible levels, whereas residual costs persisted in RGU and NG groups. These findings provide converging evidence that GD players exhibit relatively fragile proactive control and a compensatory over-reliance on reactive control. Consequently, cognitive impairment in GD reflects a shift in processing mode rather than a generalized deficit, highlighting mechanism-specific targets for clinical interventions. Full article

Strong chiral responses in planar dielectric metasurfaces are important for polarization-selective nanophotonic devices, but achieving large and reversible circular dichroism (CD) in simple dielectric structures remains challenging. This work proposes a symmetry-broken silicon metasurface that realizes near-infrared chiral response based on bound states in the continuum (BICs). The unit cell consists of a silicon nanoblock with two through-air grooves. The in-plane displacement of the air grooves breaks the C₂ rotational symmetry and splits the BIC-related polarization singularity into two circularly polarized points (C points) with opposite handedness. By further introducing out-of-plane tilting, one of the C points is shifted to the Г point, enabling spin-selective coupling between normally incident circularly polarized light and the quasi-BIC mode. Reversing the out-of-plane tilt switches the sign of CD, with values reaching −0.98 and 0.98, approaching the theoretical limits of ±1. Under oblique incidence, the structure can also exhibit near-limit CD responses. Finally, by introducing graphene, the structure achieves tunable circular-polarization-selective absorption, with the absorption of CD approaching the theoretical limits of ±0.5 for the coupled system. This work provides a new design idea for compact chiral nanophotonic materials by using symmetry breaking to control spin-selective quasi-BIC coupling and tunable chiral absorption. Full article

The interaction between light and chiral plasmonic metasurfaces provides a powerful mechanism for controlling polarization states at the nanoscale. Utilizing displacement Talbot lithography for large-area fabrication, we characterized the chiroptical response by measuring the evolution of Stokes parameters to quantify phase retardation between orthogonal polarization components. To elucidate the underlying physical mechanism, we employ a hybrid finite element method and rigorous coupled-wave analysis approach to investigate the behavior of the far-field and local-field configurations. Our results reveal that the phase shift is highly sensitive to symmetry-breaking features, where the interplay between different modes dictates the overall circular dichroism signal. Furthermore, the analysis of local field plots suggests specific contributions of plasmonic modes to the chiroptical response. We conclude that the phase shift effects, characterized via Stokes parameters and modal analysis, provide a robust metric for engineering chiroptical properties in these systems. This work establishes a fundamental framework for developing compact polarization-control elements and enhances the understanding of phase-modulated light-matter interactions in chiral plasmonic metasurfaces. Full article

Umbilical cord mesenchymal stromal cells (UC-MSCs) are a key element of regenerative medicine due to their ability to secrete growth factors that stimulate proliferation and angiogenesis, and modulate the inflammatory response. Despite their widespread use, the influence of the perinatal microenvironment on their biological properties remains poorly understood. The aim of this study was to assess the influence of pH and blood gas parameters in umbilical cord blood on the global transcriptomic profile of UC-MSCs and to analyze the correlation between the metabolic status of the newborn and the expression of key trophic factors: EGF, FGF2, FGFR1, FGFR3, GDNF, HGF, IGF1, NES, NGF, and PGF. Methods: The study was conducted in two stages. In the first phase, transcriptomic screening was performed using Affymetrix HuGene 2.0 ST microarray on cells isolated from three environmental groups defined by cord blood pH: acidic (pH < 7.35), physiological (7.35–7.39), and alkaline (pH ≥ 7.4). In the second phase, the results were validated using qPCR on an expanded study group (N = 50). Gene expression levels (RQ) were related to blood gas parameters (pH, pCO₂, pO₂, cHCO₃) and the presence of clinical features of threatened neonatal asphyxia. Results: Microarray analysis revealed that environmental pH acts as a molecular phenotypic switch. Under low pH conditions (<7.35), a shift in cell profile from proliferative to structural–migratory was observed. Significant overexpression of genes responsible for extracellular matrix (ECM) organization and adhesion (e.g., COMP, DCN, LUM, FMOD) was observed, while pathways related to cell cycle and cell division (↓CDK1, AURKA, TOP2A) were downregulated. qPCR validation confirmed these observations, demonstrating a strong positive correlation between blood pH and the expression of regenerative mediators: FGFR1 (r = 0.28), EGF (r = 0.30), NGF (r = 0.39), and IGF1 (r = 0.30). A negative correlation was also found between carbon dioxide pressure (pCO₂) and the expression of NGF, FGFR1, and EGF. A significant clinical finding was that in newborns diagnosed with threatened asphyxia, EGF, FGFR1, and NGF gene expression was significantly reduced, indicating impaired trophic potential of the cells in response to metabolic stress. Conclusions: These results indicate that cord blood gas parameters are critical regulators of the genetic activity of UC-MSCs. Metabolic and respiratory acidosis not only inhibit the cells’ proliferative potential but also force them into a matrix remodeling mode, permanently modifying their transcriptomic profile. This suggests that the neonatal acid–base status may serve as an objective indicator of the “biological quality” of isolated stromal cells, which has significant implications for their future applications in cell therapies. Full article

This study investigates the nonlinear dynamic response and chaos evolution of a shape memory alloy hybrid composite (SMAHC) actuator beam under coupled thermal, harmonic, and aerodynamic excitations. A reduced-order nonlinear dynamic model was developed by combining Euler–Bernoulli beam theory, von Karman geometric nonlinearity, the Brinson SMA constitutive relation, and first-order piston-theory aerodynamics. The governing equations were derived from Hamilton’s principle, discretized by the weighted residual method, and solved using the Newmark-beta algorithm. Chaotic evolution was quantified using a largest Lyapunov exponent-based chaos intensity indicator rather than the exact Kolmogorov–Sinai entropy. The reduced-order model was compared with ABAQUS finite element simulations under representative coupled aerodynamic and harmonic loading. The MATLAB prediction and ABAQUS response gave a dominant frequency of approximately 9.50 Hz, close to the prescribed excitation frequency of 9.55 Hz, with peak displacement amplitudes of approximately 0.0285 mm and 0.0324 mm, respectively. A supplementary ABAQUS modal-frequency separation check supported the use of the two-mode reduced-order model for the dominant low-frequency response, while also clarifying its limitation for high-dimensional chaotic modal interactions. The parametric results showed that an increasing excitation amplitude and aerodynamic load promoted frequency broadening and chaotic transitions. The Lyapunov-based indicator rose near γ = 65 under λ* = 100 and near λ* = 328 under γ = 30. Temperature-dependent SMA recovery stress further shifted the transition threshold by modifying the effective stiffness and internal restoring action of the beam. These results provide a reduced-order framework for interpreting nonlinear response transitions in SMAHC actuator beams in thermo-aeroelastic environments. Full article

Raman spectroscopic analysis of fluorite was conducted in a diamond anvil cell (DAC) over a pressure range of 0.5–20.5 GPa under different hydrostatic environments, whereas the electrical conductivity was measured at 298–873 K and 1.2–19.6 GPa. High-resolution transmission electron microscopy (HRTEM) observations were performed on both the initial and recovered samples after recovery to ambient conditions. Three representative pressure-transmitting media (PTMs), including silicone oil, the mixture of methanol and ethanol (4:1 volume ratio, ME), and helium, were employed to control the degree of hydrostaticity within the DAC sample chamber. Experimental results indicate that the pressure-induced abrupt change in A_1g, A_3g, B_1g and B_2g Raman modes, together with the discontinuities in pressure-dependent Raman shifts, Grüneisen parameters, and electrical conductivity, can efficiently characterize the α (cubic structure, space group $Fm\overline{3}m$, No 225)-to-γ (cotunnite structure, PbCl₂-type, space group Pnma, No 62) phase transition in fluorite. The transition pressures are determined to be 10.4, 9.6, 8.9 and 7.5 GPa under conditions of no PTM, silicone oil, ME and helium, respectively, demonstrating that the structural phase transition of fluorite is highly sensitive to hydrostaticity. Raman spectroscopy and electrical conductivity measurements upon decompression reveal that the phase transition is reversible, which is further confirmed by the HRTEM microstructural observation on both the initial and recovered samples. The linear relationships between electrical current and sinusoidal voltage, with the nonlinearity factors close to 1.00, manifest the Ohmic response of fluorite under high pressure. Finally, our high-temperature and high-pressure electrical conductivity results revealed the negative dependence of transition temperature on pressure, and the phase boundary between cubic and PbCl₂-type fluorite was determined as: P (GPa) = 13.057 (±1.008) − 0.008 (±0.001) T (K). The obtained phase diagram of fluorite can be employed to deeply explore the high-pressure phase stability and structural transitions of other similar binary halide family minerals. Full article

To meet the increasing demands of aircraft engines for high thrust-to-weight ratios and elevated turbine inlet temperatures, turbine blades have been progressively designed with thin-walled structures. It has been demonstrated that the mechanical properties of Ni₃Al-based single-crystal alloys (SXs) are highly sensitive to specimen thickness. In this study, the high-cycle fatigue behavior of [111]-oriented Ni₃Al-based SXs with wall thicknesses of 0.3, 0.5, and 0.8 mm was systematically investigated under tensile–tensile loading conditions at 1000 °C. The results revealed that, as the wall thickness decreased, the fatigue life of the alloy significantly deteriorated, while the crack initiation site gradually shifted from the specimen interior toward the surface and near-surface regions. Furthermore, the fatigue failure mode transitioned from being dominated by internal defects to being controlled primarily by near-surface damage. Near-surface damage induced by high-temperature oxidation and geometric constraints was identified as the primary factor responsible for the degradation of the high-cycle fatigue performance of the SXs. In addition, the cyclic deformation behavior at 1000 °C was governed by the synergistic effects of dislocation climb, cross-slip, and γ′-phase shearing. This study provides both theoretical guidance and experimental evidence for the structural optimization of next-generation single-crystal turbine blades for advanced aircraft engines. Full article

Red clay in humid-hot environments suffers from severe water sensitivity and rainfall-induced slope instability, while traditional cement/lime stabilization faces high carbon emission challenges. Existing studies on plant ash-modified red clay mainly focus on basic mechanical properties, while systematic research on water retention characteristics and slope stability under extreme rainfall in humid-hot climates remains insufficient. To address this gap, this study proposes a sustainable stabilization method using agricultural waste-derived plant ash for red clay modification in humid-hot regions. Red clay exhibits distinct engineering behaviors owing to its unique physicochemical properties, leading to compromised slope stability and reduced resistance to rainwater infiltration. In this study, red clay was stabilized with 5%, 10%, 15%, and 20% plant ash. Laboratory tests evaluated compaction characteristics, shear strength, and water retention, supported by microstructural analysis via scanning electron microscopy (SEM). Slope stability under rainfall conditions was further simulated using ABAQUS 2022 software. Key findings include: (1) The addition of plant ash significantly altered the compaction properties. As the plant ash content increased from 0% to 20%, the maximum dry density of the modified red clay decreased linearly from 1.68 g/cm³ (unmodified soil) to 1.53 g/cm³, while the optimum moisture content rose from 21.86% to 23.85%. (2) The mechanical properties exhibited a non-linear response, peaking at 10% ash content. At this optimum dosage, the unconfined compressive strength, cohesion, and internal friction angle increased by 70.4%, 83.0%, and 37.1%, respectively, compared to untreated soil. (3) Plant ash enhanced water retention capacity, shifting the soil-water characteristic curve (SWCC). The modified soil demonstrated faster dehydration at low suction but improved water retention at high suction. The permeability coefficient decreased by an order of magnitude. Microstructural analysis revealed reduced porosity and fracture infilling by cementitious gels. (4) Numerical simulations confirmed that 10% plant ash reduced maximum slope displacement from 0.96 m to 0.61 m under heavy rainfall (90 mm total precipitation over 36 h, peak intensity 90 mm/day), elevating the safety factor from 0.85 to 1.45. Failure modes transitioned from deep-seated slip to localized shallow erosion. These results demonstrate that plant ash is a sustainable and effective additive for red clay slope stabilization in tropical climates. Full article

Additively manufactured cellular architectures frequently exhibit brittle failure under impact due to layer-induced stress concentrations. Through the programming of architectural and material design, specifically combining Fused Deposition Modeling (FDM) lattice topology with hyperelastic polyurea infiltration, this study achieves active control over the macroscopic transition from catastrophic structural fragmentation to stable progressive collapse. To evaluate this, auxetic and honeycomb specimens printed with ABS and glass-fiber-reinforced polyamide (PA-GF) were evaluated in unreinforced and polyurea-infiltrated states under quasi-static compression, three-point bending, and Charpy impact loading. Results show that the compressive response depends primarily on cellular topology; the pure auxetic (A-A) configuration provided the highest stiffness and energy absorption. Polyurea infiltration did not significantly alter elastic stiffness but increased post-yield stability, leading to a 96.6% elastic recovery in PA-GF A-A structures. In flexure, the base polymer governed stiffness, with ABS structures measuring 68% stiffer than PA-GF. Unreinforced ABS achieved 34% higher specific energy absorption (SEA) than PA-GF under compression, with the A-H topology maximizing SEA. Under dynamic impact, PA-GF absorbed an average of 70% more energy than ABS, and the H-A configuration recorded the highest impact resistance. The addition of polyurea shifted the failure mode from brittle fragmentation to stable elastomeric deformation, increasing absorbed impact energy by 52% for ABS and over 30% for PA-GF, preventing catastrophic structural failure. Integrating topological sequencing with elastomeric confinement provides a direct method to control energy dissipation and damage tolerance in 3D-printed cellular composites. Full article

Rock–concrete composites are critical load-bearing elements in geotechnical engineering applications such as slope support. Their mechanical response and damage evolution after fatigue disturbances, such as blasting and mechanical operations, govern the long-term stability and safety of engineered structures. To fully capture these complex behaviors, this study presents a novel multi-scale approach by integrating uniaxial compression tests with three-dimensional digital image correlation and discrete element modeling. This combined experimental–numerical framework is employed to systematically examine the macro- and meso-scale mechanical behavior, crack evolution, and energy response of composites with varying interface angles after quasi-static cyclic loading. The results reveal that as the interface angle increases, the peak strength declines markedly while the brittleness index increases, reflecting a distinct transition in the failure mode from plastic-dissipation-dominated to elastic-energy-storage-dominated. Consequently, the dominant failure mechanism shifts from tensile to shear-slip control. Furthermore, fatigue disturbances exacerbate material degradation, inducing a composite “interface shear–end tension” failure in specimens with higher interface angles and significantly raising the proportion of shear cracks. Energy analysis indicates that cyclic loading enhances the elastic energy storage capacity, and the energy conversion threshold rises continuously with the interface angle. These findings clarify the multi-scale control mechanisms of interface geometry on fatigue-induced failure, providing a theoretical foundation for predicting fatigue life and enabling early pre-warning of failures in rock–concrete engineering structures. Full article

The accumulation of intermediate products, particularly volatile fatty acids (VFAs) like propionic acid (HPr) or its dissociated form, can inhibit biogas production during anaerobic digestion (AD) at low concentrations. Knowledge about the response of microorganisms to VFA inhibition can help control the digesters. In this study, we aimed to determine how sodium propionate (NaPr) inhibits the AD of municipal sewage sludge by identifying shifts in the microbial community. Four 5 L reactors were operated in semi-continuous mode using sewage sludge and then loaded with different levels of NaPr. The reactors operated at 37 °C with two hydraulic retention times. The results show that there was no apparent inhibition of biogas production at NaPr loading up to 20.3 mmol·L⁻¹. However, moderate inhibition was observed at 81 mmol·L⁻¹, corresponding to an approximate 10% decrease in methane production, while a ≈40% decrease in methane production was observed at 135.3 mmol·L⁻¹. Sequencing analysis revealed that the community composition was dominated by Bacillota, Bacteroidota, Proteobacteria, Chloroflexi, and Cloacimonadota, with Halobacterota and Euryarchaeota as the main archaeal groups. PERMANOVA revealed incubation time as the primary driver of community structure, followed by NaPr concentration. Elevated NaPr levels resulted in a decline in Methanothrix and Methanobrevibacter and promoted distinct syntrophic propionate-oxidizing bacteria (SPOB). Full article

Achieving adequate load capacity and ensuring ductile behavior are crucial for reinforced-concrete knee joints to prevent a complete structural collapse if an adjacent member fails. The reinforcement detailing plays a critical role in achieving these factors. In this study, the performance of a knee joint under closing moments was analyzed using innovative truss-shaped reinforcement and simplified mechanical joints, in comparison to traditional reinforcement detailing, through four large-scale specimens. The findings showed that incorporating a truss-shaped reinforcement system with the suggested detailing effectively redistributed stresses in the knee-joint area and decreased stress concentration at the bent-bar zone, thus helping to prevent premature joint failure when compared to conventional specimens. Overall, the proposed system shifted the failure mode towards a highly ductile response. Furthermore, the suggested specimen experienced significant increases in both the yield load and the ultimate load, with the yield-load boost ranging from around 29.5% to 70.5%, and the ultimate-load increase ranging from 20% to 81%. Additionally, the proposed reinforcement system exhibited notably higher displacement capacity, with increases ranging from 88% to 347%. The proposed specimen also showed a considerable enhancement in displacement ductility, with an increase of roughly 160% to 382% relative to traditional specimens. The results matched well with the created analytical models confirming the effectiveness of the proposed load-transfer system. Full article