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10 Results Found

  • Article
  • Open Access
24 Citations
3,982 Views
33 Pages

This study examined the impact of stirrer speed and bead material loading on fenofibrate particle breakage during wet stirred media milling (WSMM) via three kinetic models and a microhydrodynamic model. Evolution of median particle size was tracked v...

  • Article
  • Open Access
11 Citations
4,245 Views
29 Pages

Do Mixtures of Beads with Different Sizes Improve Wet Stirred Media Milling of Drug Suspensions?

  • Gulenay Guner,
  • Mirsad Mehaj,
  • Natasha Seetharaman,
  • Sherif Elashri,
  • Helen F. Yao,
  • Donald J. Clancy and
  • Ecevit Bilgili

The impacts of bead sizes and bead mixtures on breakage kinetics, the number of milling cycles applied to prevent overheating, and power consumption during the nanomilling of drug (griseofulvin) suspensions were investigated from both an experimental...

  • Article
  • Open Access
11 Citations
3,556 Views
35 Pages

Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

  • Donald J. Clancy,
  • Gulenay Guner,
  • Sayantan Chattoraj,
  • Helen Yao,
  • M. Connor Faith,
  • Zahra Salahshoor,
  • Kailey N. Martin and
  • Ecevit Bilgili

This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporate...

  • Article
  • Open Access
7 Citations
1,903 Views
13 Pages

Research on Hydrodynamic Characteristics of Electronic Paper Pixels Based on Electrowetting

  • Mingzhen Chen,
  • Shanling Lin,
  • Ting Mei,
  • Ziyu Xie,
  • Jianpu Lin,
  • Zhixian Lin,
  • Tailiang Guo and
  • Biao Tang

10 October 2023

In this paper, we propose a driving waveform with a complex ramp pulse for an electrowetting display system. The relationship between the contact angle and viscosity of inks was calculated based on the fluid-motion characteristics of different viscos...

  • Article
  • Open Access
32 Citations
7,875 Views
17 Pages

30 June 2015

The investigation of component dynamics is one of the main tasks of internal combustion engine (ICE) simulation. This prediction is important in order to understand complex loading conditions, which happen in a running ICE. Due to the need for fuel s...

  • Article
  • Open Access
3 Citations
2,676 Views
16 Pages

Modeling of the Electrochemical Motion Sensor Conversion Factor at High Frequencies

  • Vadim Agafonov,
  • Iuliia Kompaniets,
  • Bowen Liu and
  • Jian Chen

20 January 2022

The conversion factor of the electrochemical motion sensors at low frequencies is usually quite high. At the same time, it decreases significantly with the increase in frequency. Thus, increasing the conversion factor for high frequencies is essentia...

  • Article
  • Open Access
25 Citations
4,669 Views
20 Pages

Adequately designed and positioned surface textures are recognized as a promising way to increase load-carrying capacity and reduce frictional losses of journal bearings. The aim of this work is to analyze the local lubrication mechanisms of textures...

  • Article
  • Open Access
5 Citations
3,186 Views
21 Pages

26 November 2022

Surface topography has a significant influence on the friction behaviour in lubricated contacts. During running-in, the surface topography is continuously changed. The surface structure influences the contact stiffness (asperity contact pressure) as...

  • Review
  • Open Access
199 Citations
16,242 Views
35 Pages

Preparation of drug nanoparticles via wet media milling (nanomilling) is a very versatile drug delivery platform and is suitable for oral, injectable, inhalable, and buccal applications. Wet media milling followed by various drying processes has beco...

  • Article
  • Open Access
8 Citations
1,010 Views
28 Pages

14 February 2025

The excellent lubrication and load-bearing synergistic modulation of the meshing interface has been well recognized, as the microtextured tooth surface seems to be a punished area in deep-sea gear thermal elastohydrodynamic lubrication (TEHL). This i...