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Search Results (333)

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16 pages, 2694 KB  
Article
Leveraging Hierarchical Asymmetry for Efficient Resource Discovery in Message Queuing Telemetry Transport
by Hung-Yu Chien, An-Tong Shih and Yuh-Ming Huang
Symmetry 2025, 17(10), 1722; https://doi.org/10.3390/sym17101722 - 13 Oct 2025
Viewed by 107
Abstract
With the rapid growth of the Internet of Things, efficient resource discovery has become essential for effective resource management. Although Message Queuing Telemetry Transport is one of the most widely adopted IoT communication protocols, it lacks a native resource discovery mechanism or any [...] Read more.
With the rapid growth of the Internet of Things, efficient resource discovery has become essential for effective resource management. Although Message Queuing Telemetry Transport is one of the most widely adopted IoT communication protocols, it lacks a native resource discovery mechanism or any resource discovery standards. The existing Message Queuing Telemetry Transport resource discovery relies on symmetric full-mesh synchronization, which causes excessive traffic and unacceptable latency as the system scales up: this restricts its use to only small-size deployments. To overcome these limitations, this paper proposes a Hierarchical Message Queuing Telemetry Transport resource discovery and distribution framework, inspired by the hierarchical design of the Domain Name System. By introducing hierarchical asymmetry, the framework reduces communication overhead, enhances scalability, and maintains efficient real-time query performance, as demonstrated by implementation and simulation results. Full article
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24 pages, 24720 KB  
Article
Parallel Rendezvous Strategy for Node Association in Wi-SUN FAN Networks
by Ananias Ambrosio Quispe, Rodrigo Jardim Riella, Luciana Michelotto Iantorno, Patryk Henrique da Fonseca, Vitalio Alfonso Reguera and Evelio Martin Garcia Fernandez
Sensors 2025, 25(19), 6213; https://doi.org/10.3390/s25196213 - 7 Oct 2025
Viewed by 301
Abstract
The Wi-SUN FAN (Wireless Smart Ubiquitous Network Field Area Network) standard facilitates large-scale connectivity among smart devices in utility networks and smart cities. Specifically designed for Low-Power and Lossy Networks (LLNs), Wi-SUN FAN supports the formation of multiple Personal Area Networks (PANs) and [...] Read more.
The Wi-SUN FAN (Wireless Smart Ubiquitous Network Field Area Network) standard facilitates large-scale connectivity among smart devices in utility networks and smart cities. Specifically designed for Low-Power and Lossy Networks (LLNs), Wi-SUN FAN supports the formation of multiple Personal Area Networks (PANs) and mesh topologies with multi-hop transmissions. However, the node association process, divided into five junction states, often results in prolonged connection times, particularly in multi-hop networks, thereby limiting network scalability and reliability. This study analyzes the factors affecting these delays, with a particular focus on Join State 1 (JS1), which relies on PAN Advertisement (PA) packets that use asynchronous communication and the trickle timer algorithm, frequently causing significant delays. To overcome this challenge in JS1, we propose the Parallel Rendezvous (PR) strategy, which forms synchronized clusters of unassociated nodes and leverages the standard’s PAN Advertisement Solicit (PAS) packets to rapidly disseminate network information. The proposed algorithm, PR Wi-SUN FAN, is evaluated through simulations in various network topologies, demonstrating notable improvements in linear, fully connected, and mesh scenarios. The most significant gains are observed in the linear topology, with reductions of up to 71.22% in association time and 59.56% in energy consumption during JS1. Full article
(This article belongs to the Section Intelligent Sensors)
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31 pages, 11829 KB  
Article
Gateway-Free LoRa Mesh on ESP32: Design, Self-Healing Mechanisms, and Empirical Performance
by Danilo Arregui Almeida, Juan Chafla Altamirano, Milton Román Cañizares, Pablo Palacios Játiva, Javier Guaña-Moya and Iván Sánchez
Sensors 2025, 25(19), 6036; https://doi.org/10.3390/s25196036 - 1 Oct 2025
Viewed by 349
Abstract
LoRa is a long-range, low-power wireless communication technology widely used in Internet of Things (IoT) applications. However, its conventional implementation through Long Range Wide Area Network (LoRaWAN) presents operational constraints due to its centralized topology and reliance on gateways. To overcome these limitations, [...] Read more.
LoRa is a long-range, low-power wireless communication technology widely used in Internet of Things (IoT) applications. However, its conventional implementation through Long Range Wide Area Network (LoRaWAN) presents operational constraints due to its centralized topology and reliance on gateways. To overcome these limitations, this work designs and validates a gateway-free mesh communication system that operates directly on commercially available commodity microcontrollers, implementing lightweight self-healing mechanisms suitable for resource-constrained devices. The system, based on ESP32 microcontrollers and LoRa modulation, adopts a mesh topology with custom mechanisms including neighbor-based routing, hop-by-hop acknowledgments (ACKs), and controlled retransmissions. Reliability is achieved through hop-by-hop acknowledgments, listen-before-talk (LBT) channel access, and duplicate suppression using alternate link triggering (ALT). A modular prototype was developed and tested under three scenarios such as ideal conditions, intermediate node failure, and extended urban deployment. Results showed robust performance, achieving a Packet Delivery Ratio (PDR), the percentage of successfully delivered DATA packets over those sent, of up to 95% in controlled environments and 75% under urban conditions. In the failure scenario, an average Packet Recovery Ratio (PRR), the proportion of lost packets successfully recovered through retransmissions, of 88.33% was achieved, validating the system’s self-healing capabilities. Each scenario was executed in five independent runs, with values calculated for both traffic directions and averaged. These findings confirm that a compact and fault-tolerant LoRa mesh network, operating without gateways, can be effectively implemented on commodity ESP32-S3 + SX1262 hardware. Full article
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17 pages, 10210 KB  
Article
Feature-Driven Joint Source–Channel Coding for Robust 3D Image Transmission
by Yinuo Liu, Hao Xu, Adrian Bowman and Weichao Chen
Electronics 2025, 14(19), 3907; https://doi.org/10.3390/electronics14193907 - 30 Sep 2025
Viewed by 179
Abstract
Emerging applications like augmented reality (AR) demand efficient wireless transmission of high-resolution three-dimensional (3D) images, yet conventional systems struggle with the high data volume and vulnerability to noise. This paper proposes a novel feature-driven framework that integrates semantic source coding with deep learning-based [...] Read more.
Emerging applications like augmented reality (AR) demand efficient wireless transmission of high-resolution three-dimensional (3D) images, yet conventional systems struggle with the high data volume and vulnerability to noise. This paper proposes a novel feature-driven framework that integrates semantic source coding with deep learning-based Joint Source–Channel Coding (JSCC) for robust and efficient transmission. Instead of processing dense meshes, the method first extracts a compact set of geometric features—specifically, the ridge and valley curves that define the object’s fundamental structure. This feature representation which is extracted by the anatomical curves is then processed by an end-to-end trained JSCC encoder, mapping the semantic information directly to channel symbols. This synergistic approach drastically reduces bandwidth requirements while leveraging the inherent resilience of JSCC for graceful degradation in noisy channels. The framework demonstrates superior reconstruction fidelity and robustness compared to traditional schemes, especially in low signal-to-noise ratio (SNR) regimes, enabling practical and efficient 3D semantic communications. Full article
(This article belongs to the Special Issue AI-Empowered Communications: Towards a Wireless Metaverse)
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33 pages, 2539 KB  
Article
Centrality-Based Topology Control in Routing Protocols for Wireless Sensor Networks with Community Structure
by Juan Diego Belesaca, Andres Vazquez-Rodas, Cristihan Ruben Criollo and Luis J. de la Cruz Llopis
Electronics 2025, 14(19), 3812; https://doi.org/10.3390/electronics14193812 - 26 Sep 2025
Viewed by 688
Abstract
Wireless sensor networks (WSNs) are key enablers of efficient communication in the Internet of Things (IoT) ecosystem. These networks comprise numerous sensor nodes that collaboratively collect and transmit data, requiring adaptive and energy-efficient management. However, high node density and resource limitations introduce challenges [...] Read more.
Wireless sensor networks (WSNs) are key enablers of efficient communication in the Internet of Things (IoT) ecosystem. These networks comprise numerous sensor nodes that collaboratively collect and transmit data, requiring adaptive and energy-efficient management. However, high node density and resource limitations introduce challenges such as control overhead, packet collisions, interference, and energy inefficiency. To mitigate these issues, this paper adopts the Hybrid Wireless Mesh Protocol (HWMP), standardized under IEEE 802.11s for wireless mesh networks (WMNs), as the routing protocol in WSNs. HWMP’s hybrid design combining reactive and proactive routing is well-suited for dynamic and mobile environments, making it applicable to WSNs operating under similar conditions. Building on this foundation, we propose a community-aware topology control mechanism that constructs a Connected Dominating Set (CDS) to serve as the network’s energy-efficient backbone. Node selection is guided by centrality metrics and detected community structures to enhance routing efficiency and network longevity. The mechanism is evaluated across six mobility scenarios characterized by realistic movement patterns. Comparative results show that incorporating community structure significantly improves routing performance and reduces energy consumption, validating the approach’s effectiveness in real-world WSN deployments. Full article
(This article belongs to the Special Issue Energy-Efficient Wireless Sensor Networks for IoT Applications)
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16 pages, 6424 KB  
Article
Design and Fabrication of a Transparent Screen-Printed Decagonal Fractal Antenna Using Silver Nanoparticles
by Khaloud Aljahwari, Abdullah Abdullah, Prabhakar Jepiti and Sungjoon Lim
Fractal Fract. 2025, 9(9), 600; https://doi.org/10.3390/fractalfract9090600 - 15 Sep 2025
Viewed by 687
Abstract
This study presents a compact, wideband fractal antenna fabricated using silver nanoparticles (AgNPs) and screen-printing technology. The antenna consists of a decagonal monopole patch and a mesh ground plane, both printed on a transparent polyethylene terephthalate (PET) substrate. The proposed antenna has a [...] Read more.
This study presents a compact, wideband fractal antenna fabricated using silver nanoparticles (AgNPs) and screen-printing technology. The antenna consists of a decagonal monopole patch and a mesh ground plane, both printed on a transparent polyethylene terephthalate (PET) substrate. The proposed antenna has a compact size of 18 × 16 × 0.55 mm3, achieved by stacking two PET layers joined using double-sided tape. The antenna covers both C- and X-bands, with measured optical transmittance of 68.1% and radiation efficiency of 72%. The simulated −10 dB bandwidth (without bending) spans 4–10.8 GHz and 11.2–12.5 GHz, while the measured −10 dB bandwidth is 3.8–11.2 GHz without bending, 3–11.4 GHz at 30° bending, and 3–11.2 GHz at 45° bending, confirming that there was stable performance under flexure. The conductive patterns were formed using silver nanoparticle paste with a sheet resistance of 0.2 Ω/sq, followed by annealing in a vacuum oven at 140 °C for 20 min. The proposed antenna was tested under 30° and 45° bending, and the measured S11 remained stable, confirming flexibility. The use of a flexible, optically transparent PET substrate enables installation on curved or see-through surfaces. Combining compact size, wideband performance, cost-effective fabrication, and optical transparency, the antenna demonstrates strong potential for application in X-band radar, C-band satellite communications, and S-band Wi-Fi. Full article
(This article belongs to the Section Engineering)
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27 pages, 730 KB  
Article
Alleviating the Communication Bottleneck in Neuromorphic Computing with Custom-Designed Spiking Neural Networks
by James S. Plank, Charles P. Rizzo, Bryson Gullett, Keegan E. M. Dent and Catherine D. Schuman
J. Low Power Electron. Appl. 2025, 15(3), 50; https://doi.org/10.3390/jlpea15030050 - 8 Sep 2025
Viewed by 899
Abstract
For most, if not all, AI-accelerated hardware, communication with the agent is expensive and heavily bottlenecks the hardware performance. This omnipresent hardware restriction is also found in neuromorphic computing: a novel style of computing that involves deploying spiking neural networks to specialized hardware [...] Read more.
For most, if not all, AI-accelerated hardware, communication with the agent is expensive and heavily bottlenecks the hardware performance. This omnipresent hardware restriction is also found in neuromorphic computing: a novel style of computing that involves deploying spiking neural networks to specialized hardware to achieve low size, weight, and power (SWaP) compute. In neuromorphic computing, spike trains, times, and values are used to communicate information to, from, and within the spiking neural network. Input data, in order to be presented to a spiking neural network, must first be encoded as spikes. After processing the data, spikes are communicated by the network that represent some classification or decision that must be processed by decoder logic. In this paper, we first present principles for interconverting between spike trains, times, and values using custom-designed spiking subnetworks. Specifically, we present seven networks that encompass the 15 conversion scenarios between these encodings. We then perform three case studies where we either custom design a novel network or augment existing neural networks with these conversion subnetworks to vastly improve their communication performance with the outside world. We employ a classic space vs. time tradeoff by pushing spike data encoding and decoding techniques into the network mesh (increasing space) in order to minimize intra- and extranetwork communication time. This results in a classification inference speedup of 23× and a control inference speedup of 4.3× on field-programmable gate array hardware. Full article
(This article belongs to the Special Issue Neuromorphic Computing for Edge Applications)
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16 pages, 2835 KB  
Article
Improving Traps for Spotted Lanternflies, Lycorma delicatula (Hemiptera: Fulgoridae), by Leveraging Their Own Signals
by Miriam F. Cooperband and Kelly M. Murman
Insects 2025, 16(9), 930; https://doi.org/10.3390/insects16090930 - 4 Sep 2025
Viewed by 754
Abstract
The spotted lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae) (SLF), is a damaging invasive pest and generalist phloem feeder that has been found in 18 states in the United States. It has a complex multimodal communication system involving semiochemicals, emitted both from their honeydew and [...] Read more.
The spotted lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae) (SLF), is a damaging invasive pest and generalist phloem feeder that has been found in 18 states in the United States. It has a complex multimodal communication system involving semiochemicals, emitted both from their honeydew and their bodies, and substrate-borne vibrations. Sensitive and effective traps for detection and survey are essential management tools, but no potent lures for SLF exist yet. We sought to test an alternative that relies on live-trapped SLF acting as lures to improve trap efficacy after the first SLF is captured. SLF circle traps were modified by replacing the commonly used plastic collection bag with a mesh bag pinned to the tree trunk. These allowed the trapped SLF to remain alive and generate signals through the mesh bag, thus leveraging their natural modes of communication to draw additional SLF into the traps. We compared mesh and plastic bags over three years targeting fourth instars and adults and found that prior to oviposition, circle traps with mesh bags captured significantly more fourth instar (70% mesh: 30% plastic) and adult SLF (59% mesh: 41% plastic) compared to plastic bags, but during oviposition time, the results were mixed. Full article
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16 pages, 3585 KB  
Article
High-Performance Optically Transparent EMI Shielding Sandwich Structures Based on Irregular Aluminum Meshes: Modeling and Experiment
by Anton S. Voronin, Bogdan A. Parshin, Mstislav O. Makeev, Pavel A. Mikhalev, Yuri V. Fadeev, Fedor S. Ivanchenko, Il’ya I. Bril’, Igor A. Tambasov, Mikhail M. Simunin and Stanislav V. Khartov
Materials 2025, 18(17), 4102; https://doi.org/10.3390/ma18174102 - 1 Sep 2025
Viewed by 982
Abstract
Highly efficient shielding materials, transparent in the visible and IR ranges are becoming important in practice. This stimulates the development of cheap methods for creating transparent conductors with low sheet resistance and high optical transparency. This work presents a complex approach based on [...] Read more.
Highly efficient shielding materials, transparent in the visible and IR ranges are becoming important in practice. This stimulates the development of cheap methods for creating transparent conductors with low sheet resistance and high optical transparency. This work presents a complex approach based on preliminary modeling of the shielding characteristics of two-layer sandwich structures based on irregular aluminum mesh (IAM) formed by the cracked template method. Experimentally measured spectral dependences of the transmission coefficient of single-layer IAM are used as a reference point for modeling. According to the simulation results, two types of sandwich structures were designed using IAM, with varying filling factors and a fixed PMMA layer thickness of 4 mm. The experimentally measured shielding characteristics of the sandwich structures in the range of 0.01–7 GHz are in good agreement with the calculated data. The obtained structures demonstrate a shielding efficiency of 55.96 dB and 65.55 dB at a frequency of 3.5 GHz (the average range of 5G communications). At the same time, their optical transparency at a wavelength of 550 nm are 84.07% and 75.78%, respectively. Our sandwich structures show electromagnetic shielding performance and uniform diffraction pattern. It gives them an advantage over structures based on regular meshes. The obtained results highlight the prospect of the proposed comprehensive approach for obtaining highly efficient, low-cost optically transparent shielding structures. Such materials are needed for modern wireless communication systems and metrology applications. Full article
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18 pages, 1618 KB  
Article
The Role of Surgical and Perioperative Factors in Shaping Gut Microbiome Recovery After Colorectal Surgery
by Julia Kohn, Alexander Troester, Zachary Ziegert, Julia Frebault, Sonja Boatman, Maria Martell, Harika Nalluri-Butz, Matthew C. Bobel, Paolo Goffredo, Abigail J. Johnson, Cyrus Jahansouz, Christopher Staley and Wolfgang B. Gaertner
Antibiotics 2025, 14(9), 881; https://doi.org/10.3390/antibiotics14090881 - 31 Aug 2025
Viewed by 944
Abstract
The gut microbiome is essential for gut health, immune regulation, and metabolism, but pathogenic bacteria like Enterococcus and Streptococcus can disrupt these processes, increasing infection risk after colorectal surgery. Prior studies show that intravenous antibiotics and surgical bowel preparation (SBP, including mechanical preparation [...] Read more.
The gut microbiome is essential for gut health, immune regulation, and metabolism, but pathogenic bacteria like Enterococcus and Streptococcus can disrupt these processes, increasing infection risk after colorectal surgery. Prior studies show that intravenous antibiotics and surgical bowel preparation (SBP, including mechanical preparation with oral antibiotics) significantly disrupt the gut microbiota, potentially delaying postoperative recovery. However, the effects of surgical indication (e.g., diagnosis) and operation type on gut microbiome composition and function remain unclear. This study examines how SBP, resectional and non-resectional surgery, and underlying diagnoses shape the postoperative gut microbiome and microbial recovery. Methods: Fecal samples were collected from patients undergoing colonoscopy (n = 30), non-resectional (ventral mesh rectopexy, transanal surgery; n = 25), or resectional surgery with primary anastomosis (n = 26) at baseline, intraoperatively, and on postoperative days (POD) 10, 30, and 180. Microbial diversity was assessed through 16S rRNA sequencing, and short-chain fatty acid (SCFA) levels were measured to evaluate functional changes. Results: Alpha diversity (Shannon indices) decreased across all groups, recovering by POD10 in colonoscopy patients and by POD180 in non-resectional and resectional cohorts. Beta diversity (community composition) also returned to baseline by POD10 in colonoscopy patients and POD180 in non-resectional patients, but the resectional cohort did not fully recover (p < 0.001). Both surgical cohorts showed substantial losses of commensal bacteria through POD30, with notable increases in Streptococcus in resectional patients (p < 0.0001) and Enterococcus in both surgical cohorts (p < 0.0001). Functionally, only the resectional cohort experienced significant reductions in SCFA levels (p < 0.015) relative to baseline levels. Diagnosis minimally influenced long-term microbiota recovery, although cancer patients tended to have more stable microbiomes compared to patients with diverticulitis. Conclusions: These findings indicate that perioperative factors, especially surgical resection and SBP, significantly impact gut microbial recovery, with pathogenic bacteria persisting up to 6 months post-surgery. Full article
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33 pages, 4268 KB  
Review
Targeting Bacterial Biofilms on Medical Implants: Current and Emerging Approaches
by Alessandro Calogero Scalia and Ziba Najmi
Antibiotics 2025, 14(8), 802; https://doi.org/10.3390/antibiotics14080802 - 6 Aug 2025
Viewed by 2443
Abstract
Biofilms are structured communities of microorganisms encased in a self-produced extracellular matrix, and they represent one of the most widespread forms of microbial life on Earth. Their presence poses serious challenges in both environmental and clinical settings. In natural and industrial systems, biofilms [...] Read more.
Biofilms are structured communities of microorganisms encased in a self-produced extracellular matrix, and they represent one of the most widespread forms of microbial life on Earth. Their presence poses serious challenges in both environmental and clinical settings. In natural and industrial systems, biofilms contribute to water contamination, pipeline corrosion, and biofouling. Clinically, biofilm-associated infections are responsible for approximately 80% of all microbial infections, including endocarditis, osteomyelitis, cystic fibrosis, and chronic sinusitis. A particularly critical concern is their colonization of medical devices, where biofilms can lead to chronic infections, implant failure, and increased mortality. Implantable devices, such as orthopedic implants, cardiac pacemakers, cochlear implants, urinary catheters, and hernia meshes, are highly susceptible to microbial attachment and biofilm development. These infections are often recalcitrant to conventional antibiotics and frequently necessitate surgical revision. In the United States, over 500,000 biofilm-related implant infections occur annually, with prosthetic joint infections alone projected to incur revision surgery costs exceeding USD 500 million per year—a figure expected to rise to USD 1.62 billion by 2030. To address these challenges, surface modification of medical devices has emerged as a promising strategy to prevent bacterial adhesion and biofilm formation. This review focuses on recent advances in chemical surface functionalization using non-antibiotic agents, such as enzymes, chelating agents, quorum sensing quenching factors, biosurfactants, oxidizing compounds and nanoparticles, designed to enhance antifouling and mature biofilm eradication properties. These approaches aim not only to prevent device-associated infections but also to reduce dependence on antibiotics and mitigate the development of antimicrobial resistance. Full article
(This article belongs to the Special Issue Antibacterial and Antibiofilm Properties of Biomaterial)
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22 pages, 1272 KB  
Review
Pharmacy Technicians in Immunization Services: Mapping Roles and Responsibilities Through a Scoping Review
by Carolina Valeiro, Vítor Silva, Jorge Balteiro, Diane Patterson, Gilberto Bezerra, Karen Mealiff, Cristiano Matos, Ângelo Jesus and João Joaquim
Healthcare 2025, 13(15), 1862; https://doi.org/10.3390/healthcare13151862 - 30 Jul 2025
Cited by 1 | Viewed by 999
Abstract
Background: Pharmacy technicians are increasingly involved in immunization services, enhancing vaccine accessibility and reducing pharmacies’ workload. This scoping review aims to (1) provide a comprehensive overview of pharmacy technicians’ involvement in immunization services across various healthcare settings and countries, and (2) conduct a [...] Read more.
Background: Pharmacy technicians are increasingly involved in immunization services, enhancing vaccine accessibility and reducing pharmacies’ workload. This scoping review aims to (1) provide a comprehensive overview of pharmacy technicians’ involvement in immunization services across various healthcare settings and countries, and (2) conduct a comparative analysis of training curricula for pharmacy technicians on immunization. Methods: A scoping review was conducted following the Arksey and O’Malley framework. A comprehensive search of the PubMed and Scopus databases was performed using keywords and MeSH terms such as “pharmacy technician(s)”, “immunization”, “vaccination”, “role”, and “involvement”. Studies included assessed pharmacy technicians’ roles in vaccine administration, training, and public health outcomes. Descriptive and thematic analyses were used to synthesize the findings. In addition, a supplementary analysis of immunization training curricula was conducted, reviewing programs from different countries to identify similarities, differences, and gaps in course structure, content, and delivery formats. Lastly, a comprehensive toolkit was developed, offering guidelines intended to facilitate the implementation of immunization training programs. Results: A total of 35 articles met the inclusion criteria, primarily from the United States of America (n = 30), Canada (n = 2), Ethiopia (n = 1), Denmark (n = 1) and United Kingdom (n = 1). The findings indicate that pharmacy technicians contribute significantly to vaccine administration, patient education, and workflow optimization, particularly in community pharmacies. The COVID-19 pandemic accelerated their involvement in immunization programs. Key challenges include regulatory barriers, a lack of standardized training, and resistance from other healthcare professionals. Facilitators include legislative support (e.g., the PREP Act), structured training programs, and collaborative pharmacist–technician models. Conclusions: Pharmacy technicians can play a vital role in expanding immunization services, improving vaccine uptake, and reducing pharmacist workload. Addressing regulatory inconsistencies, enhancing training, and fostering interprofessional collaboration are crucial for their effective integration of immunization programs. Since immunization by pharmacy technicians is not yet allowed in many EU countries, this review will provide a foundational basis to address their potential to support the healthcare workforce and improve access to immunization services. Full article
(This article belongs to the Special Issue Policy Interventions to Promote Health and Prevent Disease)
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16 pages, 2709 KB  
Perspective
Fentanyl Research: Key to Fighting the Opioid Crisis
by Cristina Rius, Antonio Eleazar Serrano-López, Rut Lucas-Domínguez, Andrés Pandiella-Dominique, Carlos García-Zorita and Juan Carlos Valderrama-Zurián
J. Clin. Med. 2025, 14(15), 5187; https://doi.org/10.3390/jcm14155187 - 22 Jul 2025
Viewed by 1179
Abstract
Background/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the [...] Read more.
Background/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. Methods: To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted. A total of 53,670 documents were retrieved related to opioid scientific production, among which 1423 articles (3%) focused specifically on fentanyl. The 21,546 MeSH terms identified in these documents were analysed by publication year and specific fields: Psychiatry and Psychology, Chemicals and Drugs, Healthcare, Diseases, and Phenomena and Processes. R-statistical/FactoMineR libraries were used for the correspondence analysis. Results: In the first overdose death wave, research focused on improving therapies and reducing side effects. The second wave emphasised detoxification methods with naltrexone, methadone, and behavioural therapies. The third wave addressed psychological treatments and HIV-syringe-sharing prevention. The fourth wave prioritised less addictive analogues and understanding consumer profiles to combat the epidemic. Conclusions: Fentanyl research has evolved alongside real-world challenges, reinforcing the connection between patients’ needs, healthcare professionals’ roles, illicit users, policymakers, and the research community’s contributions to addressing both therapeutic use and its broader societal impact. These findings highlight the necessity for an interdisciplinary approach to scientific research integrating prevention, treatment, education, legal reform, and social support, emphasising the need for public health policies and collaborative research to mitigate its impact. Full article
(This article belongs to the Section Pharmacology)
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14 pages, 667 KB  
Systematic Review
The Role of Mobile Applications in Enhancing the Health-Related Quality of Life of Children with Cancer: A Systematic Review and Meta-Analysis
by Ana González-Díaz, Bibiana Pérez-Ardanaz, Nora Suleiman-Martos, José L. Gómez-Urquiza, Cristina Canals Garzón and Juan Gómez-Salgado
Children 2025, 12(7), 927; https://doi.org/10.3390/children12070927 - 14 Jul 2025
Viewed by 613
Abstract
Background/Objectives: Childhood cancer, although relatively rare, has a profound impact on the quality of life of affected children and their families. Technological advances have facilitated the development of mobile applications (apps) aimed at enhancing symptom monitoring and improving communication with healthcare teams. [...] Read more.
Background/Objectives: Childhood cancer, although relatively rare, has a profound impact on the quality of life of affected children and their families. Technological advances have facilitated the development of mobile applications (apps) aimed at enhancing symptom monitoring and improving communication with healthcare teams. This systematic review aimed to analyse the effect of mobile applications on the health of children with cancer, with a specific focus on health-related quality of life (HRQoL). Methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines. Searches were performed in PubMed (Medline), CINAHL, Cochrane and Scopus databases using MeSH terms such as Smartphone, Mobile Applications, Child Health, Neoplasms, and Digital Health, with no date restrictions, and including studies published in English, Spanish or Portuguese. We included original research studies that examined the use of mobile apps in paediatric oncology patients. The search was completed in January 2025. Results: Of the 324 records initially identified, 14 studies (mainly pilot studies, early-phase clinical trials, and observational designs) met the inclusion criteria. Interventions commonly focused on symptom tracking (pain, nausea, fatigue), promoting treatment adherence, and delivering educational content. Several studies reported high user acceptance and a potential positive impact on HRQoL, particularly when gamification strategies were incorporated to sustain children’s engagement. Conclusions: Despite the preliminary nature and small sample sizes of most studies, mobile applications appear to be effective in supporting symptom management, communication, and health education in paediatric oncology. Their use may contribute to improvements in HRQoL. Further high-quality research involving younger children and diverse socio-cultural contexts is required to confirm their effectiveness. Full article
(This article belongs to the Section Pediatric Hematology & Oncology)
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12 pages, 489 KB  
Systematic Review
Technologies and Auditory Rehabilitation Beyond Hearing Aids: An Exploratory Systematic Review
by María Camila Pinzón-Díaz, Oswal Martínez-Moreno, Natalia Marcela Castellanos-Gómez, Viviana Cardona-Posada, Frank Florez-Montes, Johnatan Vallejo-Cardona and Luis Carlos Correa-Ortiz
Audiol. Res. 2025, 15(4), 80; https://doi.org/10.3390/audiolres15040080 - 3 Jul 2025
Viewed by 1838
Abstract
Background: Traditionally, auditory rehabilitation in people with hearing loss has sought training in auditory skills to achieve an understanding of sound messages for communication. Assistive or supportive technology is limited to hearing aids that transmit sound through the air or bone to be [...] Read more.
Background: Traditionally, auditory rehabilitation in people with hearing loss has sought training in auditory skills to achieve an understanding of sound messages for communication. Assistive or supportive technology is limited to hearing aids that transmit sound through the air or bone to be used by the individual, and only in recent times have technologies for rehabilitation, of high cost and difficult access, begun to be used, employed by audiology professionals. Objective: The objective of this study was to compile the evidence reported in the literature on the use of technology in auditory rehabilitation for the improvement of hearing skills in people with hearing loss, beyond hearing aids and cochlear implants. Method: A systematic review of the literature was conducted between 2018 and 2024 in PubMed, Scopus, and Web of Science databases, using as search terms Technology AND “Auditory Rehabilitation” validated in DeCS and MeSH thesauri; the PICO method was used to propose the research question, and the PRISMA strategy was used for the inclusion or exclusion of the articles to be reviewed. Results: In the first search, 141 documents were obtained. Subsequently, inclusion criteria, such as development with vibrotactile stimulation, Information and Communication Technologies (ICTs), among others, and exclusion criteria, such as those related to cochlear implants and air conduction hearing aids, were applied, and finally, articles related to natural language processing, and other systematic reviews were excluded so that the database was reduced to 14 documents. To this set, due to their relevance, two papers were added, for a total of sixteen analyzed. Conclusions: There are solutions ranging from the use of smartphones for telehealth to solutions with multiple technologies, such as the development of virtual environments with vibrotactile feedback. Hearing-impaired people and even professionals in this area of healthcare have a high level of acceptance of the use of technology in rehabilitation. Finally, this article highlights the crucial role of technology in auditory rehabilitation, with solutions that improve hearing skills and the positive acceptance of these tools by patients and audiology professionals. Full article
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