Search Results (10,166)

In order to tackle resilient supplier selection (RSS) of high uncertainty in resilient supply chain management, an effective correlation coefficients-based multicriteria group decision-making (MCGDM) methodology has been constructed. The major contribution of the present study is twofold. Firstly, in view of that extant criteria systems are all in lack of theoretical rationality, this paper establishes a capabilities-based analytical framework for intensive evaluation of supplier resilience by taking processual viewpoints of dynamic capabilities theory and risk management theory. Secondly, to empower the proposed correlation coefficients-based MCGDM methodology, probabilistic dual hesitant fuzzy uncertain unbalanced linguistic set (PDHF_UUBLS) is employed to capture hybrid uncertainties in decision processes of RSS. Then, theoretically compliant correlation coefficients (CCs) for PDHF_UUBLS are developed, including statistics-based CC, information energy-based CC and their weighted versions. Especially, information energy-based CCs overcome limitations of statistics-based CCs in special cases, thus exhibiting general applicability. In addition, a compatibility-based programming model has also been developed to objectively derive an unknown weighting vector for DMUs. Furthermore, illustrative case studies and comparative experiments have been carried out to verify effectiveness and stability of the proposed methodology. Taken together, this paper satisfies the new normal demand of resilience building in supply chain management and presents an effective MCGDM methodology for handling the key problems of RSS. Full article

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance “vitality,” is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O. sinensis is standardized for its adenosine content, the precursor of ATP, which mediates numerous physiological and pathological processes in many diseases. The related fungus of order Hypocreales, Cordyceps militaris, and its major bioactive constituents, 3′-deoxyadenosine (cordycepin), also exhibit pleiotropic biological activities. This review aims to provide a rationale for the adaptogenic and resilience-supporting effects of these medicinal fungi and to align food and drug regulation in Western countries. Methods: In this narrative review, we integrated results from chemical, pharmacokinetic, network pharmacology, preclinical, and clinical studies of O. sinensis, C. militaris, and cordycepin using network pharmacology and bioinformatics tools. Results: Across studies, recurrent mechanistic hubs included PI3K–Akt, AMPK–mTOR, MAPK, NF-κB, apoptosis, and adaptive stress-response signaling pathways, linking immune regulation and metabolic homeostasis. Experimental studies confirmed modulation of cytokine production, kinase signaling, and mitochondrial regulators. Clinical meta-analyses demonstrate consistent adjunctive benefits in renal and pulmonary disorders, although heterogeneity in preparation and methodological limitations remains significant. The review reveals controversy regarding the bioavailability of cordycepin in vivo and its concentration in vitro studies, raising the hypothesis that cordycepin may act as a driver, triggering the organism’s adaptive stress response in stress-induced and aging-related diseases. Pharmacokinetic data indicate that systemic cordycepin concentrations after oral administration remain in the nanomolar range, suggesting that some predicted molecular interactions may occur indirectly or through systems-level mechanisms. The review, for the first time, suggests establishing a regulatory category for resilience-supporting physiological modulators to align food and drug regulation in the EU with contemporary systems biology, thereby complementing the work of EFSA, EMA, FDA, and Asian authorities. Conclusions: O. sinensis, C. militaris, and 3-deoxyadenosine share a common adaptogenic mechanism for maintaining homeostasis of cellular and integrated biological system functions. The systems-level network analysis and reductionistic molecular ligand preceptor pharmacology provide complementary approaches for understanding the multi-target bioactivity of these fungi. This review clarifies conceptual and regulatory barriers to recognizing resilience-supporting interventions and informs future regulatory innovation. Full article

Consistency checking across independently developed implementations of the same industrial control protocol provides an effective signal for defect discovery because an implementation whose response deviates from the majority under identical inputs is more likely to contain faults or robustness issues. However, existing consistency checking methods remain difficult to apply to complex stateful protocols in practice, since sequence dependencies can cause error propagation, large test suites incur high execution cost across multiple implementations, and inconsistent outputs are costly to triage. This paper proposes ConDiffFuzz, a dependency-aware and dynamically adjusted hierarchical consistency checking method for industrial control protocol implementations. ConDiffFuzz analyzes dependencies among check sequences to optimize execution order and dynamically prunes and regenerates dependent sequences after failures to mitigate inconsistency error propagation. The checking process derives implementation-specific finite state machines and inconsistency records, which further support focused differential fuzzing, parallel execution across multiple implementations, and log-based anomaly triage. Experiments on five Modbus over Modbus/TCP implementations show that ConDiffFuzz achieves a test case acceptance rate of 86.00%, increases average path coverage to 74.46%, improves the average number of triggered anomalies by 12.28%, and reduces the false-positive rate by 20.94% compared with four representative baseline fuzzers (SPIKE, BooFuzz, PeachFuzzer, and Kitty). Full article

A major drawback of many proposed biobased alternatives of the most commonly used petroleum-based packaging materials is their relatively poor physical properties. In order to develop more viable alternative packaging materials, these properties need to be modified, while maintaining and improving the other desired characteristics. An investigation was done on corona-charged curcumin-containing PLA films to determine how the addition of the polyphenol impacts its physical properties. Measurements of the surface potential of the films were performed, as was the impact of low pressure on the electret properties. The effect of the corona discharge treatment on the physicochemistry of the surface of composite PLA films was investigated systematically using some complementary surface analytical techniques, such as surface wettability and morphology by scanning electron microscopy. The mechanical properties and conductance of the films were also investigated. A dependency of the decay of the surface potential on the film type and the polarity of the corona was found. It was also established that modifying the surface of the films with corona discharge can cause an increase in their wettability and surface free energy, while also improving their adhesion properties. This is caused by the creation of polar functional groups on the film surface during the charging process. It was also determined that the introduction of curcumin in the PLA films decreases their stiffness, which may be caused by a decrease in intramolecular cohesion. Full article

The most common species of tick in Europe is the castor bean tick (Ixodes ricinus), which is found in forests, parks, and gardens and is active almost all year round. Ticks are among the most important arthropods and vectors of disease, transmitting a wide range of parasites that sometimes lead to the death of infected organisms. The peak incidence of tick-borne diseases occurs between May and September; however, due to global warming, people are increasingly exposed to tick-borne diseases throughout the year. In order to increase the possibility of preventing the transmission of diseases by ticks, it is necessary to become thoroughly familiar with the life cycle of ticks and the environment in which they live. Vaccines are available for some diseases, such as tick-borne encephalitis, while others require a highly specific diagnosis. Another major problem is the long period between the tick bite, which often goes unnoticed or is even ignored by the patient or the doctor, and the development of tick-borne diseases. Increasing attention is being paid to the prevention of tick-borne diseases through prevention of tick bites, quick tick removal, use of repellents, appropriate land management, vaccinations, and the use of plants as natural acaricides. Full article

Glycosphingolipids are amphiphilic compounds that feature sugar or glycan moieties installed onto a ceramide lipid. The synthesis of glycosphingolipids by members of the human gut microbiome, and their known immune stimulating activity, have made them of interest for potential pharmaceutical roles. However, the known diversity of glycosphingolipid glycans in bacteria remains limited, highlighting the need to isolate novel glycosphingolipid-producing organisms as a source of these compounds. The order Sphingomonadales, one of the major clades of sphingolipid producing bacteria, conserves a serine palmitoyltransferase (SPT) enzyme needed for the initial biosynthetic step in sphingolipid production which can be targeted as part of isolation efforts. With these bacteria known to live in diverse environments such as soil microbiomes, soap scum biofilms, and cyanobacterial microbiomes, there are many environments to target for the isolation of these bacteria. In this work, we designed a set of polymerase chain reaction (PCR) primers for the isolation of diverse Sphingomonadales strains by targeting the SPT gene (spt), which we used to isolate strains from the genera Sphingomonas and Novosphingobium in soil, soap scum biofilms, and xenic cyanobacterial cultures. In these efforts, streptomycin improved the encounter rate, as represented by the SPT assay true-positive rate. Our isolates represent novel genomic space: with genomes from both genera that have low similarity to known genomes, suggestive of novel species, while several novel plasmids were also missing known marker sequences. Full article

During the early years of interaction between humans and computer systems, user authentication and identification was carried out with the support of knowledge-based factors (something the user knows: passwords, PINs, etc.) and tokens (something the user possesses: credentials, RFID cards, etc.) or a combination of both. In other words, the user presents a token and a password to the system in order to gain access. These solutions pose major challenges: Knowledge-based systems, which rely on secrets like passwords, are vulnerable to those secrets being guessed, shared, or forgotten. On the other hand, tokens are also vulnerable; some, despite implementing encryption, attract cyber attackers who can forge them, and users can share or lose them. In the search for more robust methods, the use of biometrics has been considered. Full article

Background and Aim: The correct identification of patients presenting with chest pain and the stratification of their risk for major adverse cardiovascular events (MACE) is essential. The aim of this study was to evaluate subjects who came to the ED for chest pain through the chest pain score, the HEART score and the TIMI risk score in order to assess their validity and prognostic accuracy and to compare their performance. Methods: Patients included in the study met the following criteria: age ≥18 years, reported atraumatic chest pain, and consent to participate in the clinical study. Subsequently, the final scores were calculated based on the information collected and a follow-up was performed to assess the occurrence of adverse cardiovascular events (MACEs) at 30 days. The MACEs considered were a composite endpoint of STEMI or NSTEMI myocardial infarction, positive coronary angiography for critical lesions, percutaneous coronary angioplasty, coronary artery bypass grafting, and death. Results: A total of 102 patients were included in the study sample, divided into 76 patients who did not develop MACEs and 26 patients who experienced MACEs. The AUC values of the ROC curves of the chest pain score, HEART score and TIMI risk score were 0.8312, 0.9757 and 0.9378 respectively. Conclusions: All three scores examined were considered excellent tools to predict the onset of MACEs in patients with chest pain at different points of clinical management, although the HEART score outperformed both the chest pain score and the TIMI risk score in terms of prognostic accuracy. Full article

Wastewaters from the food industry and domestic sources contain large amounts of ammonium, a major contributor to eutrophication. Recovering this nutrient for fertilizer use offers both environmental and agricultural benefits. Poplar chop-derived biochars were prepared under different pyrolysis temperatures (300–500 °C) and chemical modifications (acidic and alkaline) to optimize ammonium (NH₄⁺) adsorption and fertilizer reuse. The biochars were characterized by zeta potential, SEM–EDX, FTIR, and specific surface area measurements. Batch adsorption tests revealed that the alkaline-modified biochar produced at 300 °C achieved the highest capacity (4.63 mg NH₄⁺/g biochar) and 62% removal efficiency. Adsorption kinetics followed a pseudo-second-order model (R² = 0.97) but showed only marginal differences among models without independent mechanistic evidence. The Temkin isotherm described the equilibrium data the best (R² > 0.99). Ammonium-enriched biochars enhanced seed germination by up to 54% compared to the control and increased plant biomass up to 12-fold in pot experiments. These results demonstrate that optimized biochars can effectively recover ammonium from wastewater; moreover, the observed plant growth improvement suggests potential slow-release behavior, promoting nutrient recycling and sustainable agriculture. Full article

Petroleum hydrocarbons remain major environmental contaminants, and understanding the mechanisms governing their biodegradation is essential for designing effective remediation plans. The strategy in this article is slightly different from other cases in the literature. Such literature models require, for their elaboration, a significant number of experiments; the number of experimental determinations is at least proportional to the square of the number of constants introduced in the mathematical expressions. For this reason, the strategy followed in this article is different—starting from a set of experiments carried out and presented in a coherent and published manner, a simple methodology for building specific and minimal models, which will allow solving specific problems, was effectively developed. This study develops a nonlinear mathematical structure, expressed as a system of coupled differential equations, that simultaneously describes the degradation of petroleum hydrocarbons and the dynamics of hydrocarbon-degrading bacteria and fungi in soil–sludge mixtures. The model was calibrated using experimental data obtained from biopiles prepared with different volumetric ratios of contaminated soil and sewage sludge. Approximate analytical solutions were derived and the distributed constants were evaluated. For a consistent discussion, the analytical solutions were assessed against numerical desk simulations performed with a classical fourth-order Runge–Kutta method, which accurately reproduced the nonlinear behavior of the specific system. This numerical approach was chosen in order to overcome the proper difficulties encountered in this strategy implementation. The results show that the soil–sludge ratio strongly influences biodegradation efficiency, while kinetic parameters determine whether microbial communities evolve toward a stationary regime or accelerated contaminant removal. The combined analytical–numerical framework provides a robust predictive tool for optimizing mixture composition and improving the design of bioremediation treatments for petroleum-contaminated soils. Full article

Ground deformation is a major geohazard in many urban areas, requiring reliable monitoring and forecasting for hazard mitigation. Although Multi-Temporal InSAR enables high-resolution deformation monitoring, most prediction approaches rely on single-point modeling and fail to exploit spatial dependencies within deformation fields. This study proposes a spatiotemporally synchronous prediction framework for large-scale InSAR deformation fields, integrating sequence preprocessing, spatiotemporal modeling, and deformation pattern analysis. First-order differencing reduces sequence non-stationarity, while a patch-based encoder-decoder structure preserves spatial topology during dimensionality reduction. The core prediction model, built on PredRNNv2, captures the long-term spatiotemporal evolution of InSAR deformation sequences. In addition, independent component analysis (ICA) combined with K-means clustering identifies dominant deformation patterns and their geological associations. The framework is evaluated using synthetic datasets simulating multiple deformation mechanisms and Sentinel-1 InSAR time-series data over the Beijing Plain from 2015 to 2025. Results show that the model accurately captures deformation evolution and identifies transitions associated with groundwater regulation. These findings demonstrate the potential of deep spatiotemporal learning for large-scale InSAR deformation prediction and geohazard mechanism interpretation. Full article

In the past five years, China has continuously strengthened its policy support for the development of new-type agricultural business entities. However, the implementation of these policies has faced various complexities, and the specific effectiveness of such support remains unclear. Additionally, many aspects of rural support policies need improvement. This study, based on survey data from 1349 rural households in Shandong Province, a major agricultural region in China, employs Pareto analysis and a multinomial ordered Probit model to examine the effectiveness and influencing factors of policies supporting new-type agricultural business entities. The results show the following: (1) the overall satisfaction of farmers with the support policies falls between “neutral” and “relatively satisfied,” with a mean score of 3.69; (2) factors such as the ease of obtaining financial support, the amount of government subsidies, policy awareness, evaluations of tax policies, and land use regulations have a positive influence on satisfaction with the support policies. Based on these findings, we recommend innovating fiscal and tax subsidy mechanisms and strengthening the dissemination and publicity of agricultural support policies to ensure their effective and orderly implementation. Additionally, it is essential to improve land use regulation policies and rural property rights trading mechanisms to promote the rational allocation of resources, enhance policy-oriented agricultural insurance to fully harness its income-enhancing effects for agricultural producers, thereby ensuring the long-term stability and sustainable development of the policy support system for new-type agricultural business entities. Full article

Hollow graphitic nanoshells (HGSs) are widely investigated as battery materials because their conductive shells and internal voids can simultaneously influence ion transport, electron percolation, and mechanical stress accommodation. Yet, the field remains largely morphology-driven, with performance often attributed generically to “hollowness” rather than to structural parameters. This review examines HGSs from a parameter-oriented perspective. It highlights key structural features, including graphitization degree, shell thickness, cavity size, pore architecture, and defect or dopant chemistry. These features collectively shape electrochemical behavior. We discuss how these features influence transport kinetics, interphase stability, volumetric efficiency, and mechanical resilience across insertion, metal anode, multivalent, solid-state, and halogen chemistries. Major synthesis approaches, including hard-templated, soft-templated, self-templated, and biomass-derived routes, are evaluated based on the structural control they provide and the influence of synthesis conditions on shell architecture, graphitic ordering, and pore structure. Special attention is given to how these structural features develop during processing and how they affect ion accessibility, conductivity, and stability. Finally, we outline a shift toward quantitative, parameter-driven engineering supported by operando diagnostics, electrode-level modeling, and standardized reporting. HGSs will only achieve practical relevance when structural optimization extends beyond particle morphology to transport uniformity, interfacial stability, network connectivity, and life-cycle responsibility. Full article

Heavy metal pollution from mining activities and urban runoff poses a serious threat to public health and aquatic ecosystems in vulnerable communities around the Bolivia–Peru transboundary Lake Titicaca basin. This study evaluates the use of two abundant wetland plants—totora (Schoenoplectus californicus) and reed (Phragmites australis)—as low-cost, locally available biosorbents for the removal of dissolved iron (Fe²⁺) from the Pallina River, a major contaminant source to Cohana Bay. Monitoring data from Bolivia’s Ministry of Environment and Water (2019–2022) revealed Fe²⁺ concentrations exceeding the national legal limit (0.3 mg/L) by more than 20 times during the dry season. Laboratory experiments using synthetic Fe²⁺ solutions (20 mg/L) optimized biosorption conditions, identifying pH 5, 4–6 g/L biomass, fine particle size (0.15–0.212 mm), and a 3 h contact time as optimal. Both plants followed pseudo-second-order kinetics and Langmuir isotherms. Totora showed superior performance, achieving a maximum capacity of 7.8 mg/g compared to reed’s 2.9 mg/g. Continuous-flow column tests removed up to 95% of Fe²⁺ from synthetic water. When applied to real Pallina River water, totora achieved 50% Fe²⁺ removal despite reduced efficiency due to competing organic matter. The findings demonstrate the potential of totora-based biosorption as a scalable, nature-based solution for transboundary water management. The policy implications of this study are profound under the national and global water and wetland governance mechanisms and transboundary frameworks like the Binational Autonomous Authority of Lake Titicaca (ALT, est. 1996) and Ramsar Convention. Full article

The order Herpesvirales contains three families, Orthoherpesviridae, Alloherpesviridae, and Malacoherpesviridae. The time since divergence of families from the common ancestor makes protein primary sequence comparison an insensitive tool for identifying common genes. Comparison of three-dimensional protein structures can reveal similarities that are not evident in primary sequences. Salmonid herpesvirus 1 (SalHV-1) is an alloherpesvirus. Complete sequencing of SalHV-1 VR-868 strain Winthrop by a combination of short- and long-read methods revealed 120 putative open reading frames (ORFs). BLAST search for similar protein sequences discovered five ORFs that encoded proteins with homologs in the orthoherpesviruses, including the major capsid protein, capsid triplex subunit 2, the catalytic subunit of the DNA polymerase, the helicase subunit of the helicase/primase complex, and the terminase ATPase subunit. An annotation of the ORFs of SalHV-1 was performed in which ORFs of SalHV-1 were modeled using AlphaFold3, and the models were used as prompts for structural similarity search using DALI and FoldSeek. Completion of this search strategy for the entire genome expanded the set of genes shared among the Herpesvirales to include additional proteins related to DNA replication and genome integrity, capsid assembly and genome packaging, and capsid nuclear egress. No homologs for any tegument proteins or proteins of the conserved entry apparatus of the Herpesviridae (gB, gH or gL) were discovered. Full article