Search Results (36)

The seawater circulation pump represents the pump product with the largest flow rate within nuclear power plants. Its energy consumption accounts for a substantial portion of the energy consumed by nuclear power plants. To investigate the internal flow characteristics of the seawater circulation pump and optimize the performance while reducing energy consumption, taking the seawater circulation pump as the research object, the entropy production of each flow passage component of the pump under different flow conditions are analyzed by employing numerical simulation based on the entropy production theory. Additionally, the entropy production mechanisms of the impeller and volute are specifically analyzed. The results demonstrate that under different flow conditions, the impeller and volute are the main flow components contributing to entropy production losses for the entire pump. The leading and trailing edges of the blade and the shroud are the main locations where entropy production occurs in the impeller. Excessive attack angle and circulation are the main factors leading to entropy production. The throat area of the volute is the main entropy production area of the volute, and the secondary flow and vortex caused by flow separation are the main causes of entropy production. Full article

Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) causes a systemic inflammatory response that can worsen patient outcomes. Off-pump surgery has been associated with a reduced inflammatory response. The precise mechanisms and the role of extracellular vesicles (EVs) in this context are not fully understood. This study aimed to investigate the early immune response, including main T- and B-lymphocyte subsets, cytokine profiles, and plasma EVs, in patients undergoing off-pump (n = 18) and on-pump (n = 18) CABG. Thirty-six patients undergoing isolated CABG were enrolled in this randomized control study. Pre- and 24 h postoperative blood samples were analyzed for immune cell populations, cytokine levels, and plasma EV phenotyping. Off-pump CABG triggered a milder immune response than on-pump surgery. On-pump surgery led to greater changes in circulating EVs, particularly platelet- (CD62P+), endothelial- (CD31+), and B-cell-derived (CD19+), as well as platelet- and erythrocyte-derived aggregates (CD41+CD235a+). Levels of platelet-derived EVs, expressing both constitutional and activation markers (CD41+CD62P+) decreased in both groups of patients 24 h after surgery. On-pump cardiac procedures led to an increase in T-regulatory cell-derived EVs (CD73+CD39+), suggesting a potential mechanism for immune suppression compared to off-pump surgery. There were numerous correlations between EV levels and cytokine profiles following on-pump surgery, hinting at a close relationship. Leucocyte-derived EVs exhibited positive correlations with each other and with GRO but showed negative correlations with endothelial-derived EVs (CD90+ and CD31+). Additionally, CD73+ EVs demonstrated positive correlations with platelet counts and with erythrocyte-derived CD235a+ EVs. EV changes were significantly greater after on-pump surgery, highlighting a more pronounced response to this type of surgery and emphasizing the role of EVs as regulators of post-surgical inflammation. Full article

Right-sided mechanical support of the Fontan circulation by existing devices has been compounded by the cross-sectional design of vena cava anastomosis to both pulmonary arteries. Our purpose was to investigate whether increasing inferior vena cava (IVC) flow with a rotary blood pump in the IVC only in an ovine animal model of Fontan would lead to acceptable superior vena cava (SVC) pressure. To achieve this, a Fontan circulation was established in four female sheep by anastomosing the SVC to the main pulmonary artery (MPA) and by interposing a Dacron graft between the IVC and the MPA. A rotary blood pump was then introduced in the graft, and the effect of incremental flows was observed at increasing flow regimen. Additionally, to stimulate increased pulmonary resistance, the experience was repeated in each animal with the placement of a restrictive band on the MPA distally to the SVC and Dacron graft anastomosis. Circulatory support of IVC flow alone increased the systemic cardiac output significantly, both with and without banding, indicating the feasibility of mechanical support of the Fontan circulation by increasing the flow only in the inferior vena cava. The increase in SVC pressure remained within acceptable limits, indicating the potential effectiveness of this mode of support. The findings suggest that increasing the flow only in the inferior vena cava is a feasible method for mechanical support of the Fontan circulation, potentially leading to an increase in cardiac output with acceptable increases in superior vena cava pressure. Full article

Basal insulin analogs, typically administered once or twice daily, have been one of the two pillars of the multiple daily injection (MDI) insulin therapy of patients with type 1 diabetes (T1D) for the last twenty years. Recently, once-weekly basal insulin analogs have been developed and are in late-phase clinical trials. One of these analogs is insulin icodec (icodec), appropriately developed to bind reversibly to albumin and to be gradually released into the patient’s circulation. Icodec has been tried mostly in clinical trials of adult patients with type 2 diabetes. A recent phase 3a clinical trial comprising adult patients with T1D was designed to evaluate icodec’s efficacy and safety compared with a daily basal insulin analog (degludec) after a 26-week main phase plus a safety extension of another 26 weeks. Icodec showed non-inferiority to once-daily degludec in glycated hemoglobin (HbA1c) reduction at week 26, and no significant differences in time in range (TIR) (70–180 mg/dL) and in time above range (TAR) (>180 mg/dL). On the other hand, it was associated with increased rates of clinically significant hypoglycemia (blood glucose < 54 mg/dL) and severe hypoglycemia (external assistance need for recovery), remaining either below or close to the internationally recommended targets for hypoglycemia. Another once-weekly insulin analog, basal insulin Fc (BIF), has been investigated in a phase 2 clinical trial comprising adult patients with T1D, with equally promising results. These preliminary data suggest that once-weekly insulin analogs could be of use for some patients with T1D, for example, patients not taking insulin regularly or those who are on MDI and wish for fewer injections. In addition, due to its prolonged mode of action, it could decrease the risk of diabetic ketoacidosis and the need for hospitalization. Additionally, patients with T1D that struggle with wearing diabetes mellitus devices/closed-loop insulin pumps either due to the cost or due to skin issues may also benefit from long-acting insulin. There is increasing evidence of the benefits of adjunctive therapies to insulin in T1D patients, but these therapies are not FDA-approved due to a possible higher risk of diabetic ketoacidosis. These long-acting insulin analogues could be used with adjunctive therapies in selected patients. This review aims to present available data on the mode of action, clinical trial results, and possible benefits of once-weekly insulin analogs for patients with T1D. In addition, it intends to suggest a future research framework for important clinical questions, such as once-weekly insulin analog use and exercise, sick days, or surgery, that will enhance our knowledge regarding this indisputable innovation in insulin management. Full article

The hydrogen cycle system, one of the main systems used for hydrogen fuel cells, has many advantages. It can improve the efficiency, the water capacity, and the management of thermal fuel cells. It can also enhance the safety of the system. Therefore, it is widely used in hydrogen fuel cell vehicles. We introduce the structure and principles of hydrogen cycle pumps, ejectors, and steam separators and analyze and summarize the advantages of the components, as well as reviewing the latest research progress and industrialization status of hydrogen cycle pumps and ejectors. The technical challenges in hydrogen circulation systems and the development direction of key technologies in the future are discussed. This paper aims to provide a reference for research concerning hydrogen energy storage application technology in hydrogen fuel cell systems. Full article

The reactor control rod drive mechanism (CRDM) controls the startup, shutdown and power of the reactor; it is one of the key pieces of equipment to ensure the normal operation of the reactor. CRDM is complex, mainly composed of stator, rotor, bearing, roller, etc. The characteristic analysis of the vibration monitoring signal is one of the important methods of the CRDM state evaluation. In view of the characteristics of large noise interference and the difficulty in analyzing the vibration monitoring signal of CRDM, this paper proposes a noise reduction method for the vibration signal of CRDM based on complete ensemble empirical mode decomposition with adaptive amplitude correction noise and spectral kurtosis (CEEMDAACN-SK), which can deeply reduce the vibration signal of CRDM. Firstly, the proposed CEEMDAACN algorithm is used to decompose the vibration signal of CRDM to obtain multiple intrinsic mode functions (IMF). Then, the spectral kurtosis of each IMF component is analyzed to obtain the spectral kurtosis map of each IMF component, which is compared with the spectral kurtosis map of the original signal. Finally, the denoising reconstruction of the signal is carried out to obtain the final denoising signal. Through experimental analysis, the performance of the proposed CEEMDAACN-SK denoising algorithm is better than the complete ensemble empirical mode decomposition with adaptive noise and spectral kurtosis (CEEMDAN-SK) algorithm in terms of results. The method proposed in this paper can be applied not only to the vibration signal noise reduction of CRDM, but also to other equipment and fields, such as nuclear power main circulation pump and the chemical industry. Full article

The “Warburg effect” consists of a metabolic shift in energy production from oxidative phosphorylation to glycolysis. The continuous activation of glycolysis in cancer cells causes rapid energy production and an increase in lactate, leading to the acidification of the tumour microenvironment, chemo- and radioresistance, as well as poor patient survival. Nevertheless, the mitochondrial metabolism can be also involved in aggressive cancer characteristics. The metabolic differences between cancer and normal tissues can be considered the Achilles heel of cancer, offering a strategy for new therapies. One of the main causes of treatment resistance consists of the increased expression of efflux pumps, and multidrug resistance (MDR) proteins, which are able to export chemotherapeutics out of the cell. Cells expressing MDR proteins require ATP to mediate the efflux of their drug substrates. Thus, inhibition of the main energy-producing pathways in cancer cells, not only induces cancer cell death per se, but also overcomes multidrug resistance. Given that most anticancer drugs do not have the ability to distinguish normal cells from cancer cells, a number of drug delivery systems have been developed. These nanodrug delivery systems provide flexible and effective methods to overcome MDR by facilitating cellular uptake, increasing drug accumulation, reducing drug efflux, improving targeted drug delivery, co-administering synergistic agents, and increasing the half-life of drugs in circulation. Full article

The aim of cardiopulmonary bypass is the maintenance of a sufficient whole body perfusion and gas exchange during open or closed heart surgery procedure (coronary artery bypass grafting, valve repair and replacement, surgical intervention on the ascending aorta and/or aortic arch, repair of congenital malformations, and finally implantation of ventricular assist devices or cardiac transplantation). The main components of cardiopulmonary bypass are the pump that supplies the circulation and the oxygenator that regulates gas exchange. However, even though this technology has been extensively developed and improved over the last decades, one of the major drawbacks—which is the fact that blood has to flow through tubing systems with foreign surfaces—persists so far. Nevertheless, interesting innovations have been made more recently in order to better control the side-effects that culminate into a major activation of the coagulation and inflammatory systems: among them, miniaturization of the circuits, together with reduction of the priming volume and a simplified cardioplegia concept. All of these lead to a significant decrease of hemodilution and thereby a significant reduction of volume overload during surgery. In this brief review we will present some of these most interesting topics around minimized circuits and the simplified low-volume cardioplegia and discuss their potential benefits on the clinical outcome. Full article

The intelligent fault diagnosis of main circulation pumps is crucial for ensuring their safe and stable operation. However, limited research has been conducted on this topic, and applying existing fault diagnosis methods designed for other equipment may not yield optimal results when directly used for main circulation pump fault diagnosis. To address this issue, we propose a novel ensemble fault diagnosis model for the main circulation pumps of converter valves in voltage source converter-based high voltage direct current transmission (VSG-HVDC) systems. The proposed model employs a set of base learners already able to achieve satisfying fault diagnosis performance and a weighting model based on deep reinforcement learning that synthesizes the outputs of these base learners and assigns different weights to obtain the final fault diagnosis results. The experimental results demonstrate that the proposed model outperforms alternative approaches, achieving an accuracy of 95.00% and an F₁ score of 90.48%. Compared to the widely used long and short-term memory artificial neural network (LSTM), the proposed model exhibits improvements of 4.06% in accuracy and 7.85% in F₁ score. Furthermore, it surpasses the latest existing ensemble model based on the improved sparrow algorithm, with enhancements of 1.56% in accuracy and 2.91% in F₁ score. This work presents a data-driven tool with high accuracy for the fault diagnosis of main circulation pumps, which plays a critical role in maintaining the operational stability of VSG-HVDC systems and satisfying the unmanned requirements of offshore flexible platform cooling systems. Full article

Electrical insulation failure is the most common failure mechanism in electrical machines (motors and generators). High temperatures and/or temperature gradients (HTTG) are the main drivers of insulation failure in electrical machines. HTTG combine with and augment other destructive effects from over-voltage, to voltage transients, overload and load variations, poor construction techniques, and thermal cycling. These operating conditions cause insulation damage that leads to electrical insulation failure. The insulation failure process is greatly accelerated by pollutants and moisture absorption. A simple and robust way to reduce HTTG and moisture adsorption is by maintaining constant internal temperatures. The current method to maintain elevated internal temperatures and reduce condensation issues is by internal electrical heating elements. This paper examines the effectiveness of applying thermoelectric coolers (TECs), solid-state heat pumps (Peltier devices), as heaters to raise a motor’s internal temperature by pumping heat into the motor core rather than heating the internal air. TEC technology is relatively new, and the application of TECs to heat a motor’s internal volume has not previously been explored. In this paper, we explore the hypothesis that TECs can pump heat into a motor when out of service, reducing the HTTG by maintaining high winding slot temperatures and eliminating condensation issues. This paper describes a test motor setup with simple resistive heating (traditional method), compared with the application of TECs with heat sinks, heat pipes, and a water circulation heat exchanger, to gauge the capability of TECs to heat the inner core or winding area. In this paper, we demonstrate the full integration of TECs into a motor. The results show that each of the systems incorporating the TECs would effectively pump heat into the core and keep the winding hot, eliminating condensation issues and water ingress due to thermal cycling. Full article

E. coli O157:H7 is a known Shiga toxin-producing Escherichia coli (STEC), causing foodborne disease globally. Cattle are the main reservoir and consumption of beef and beef products contaminated with E. coli O157:H7 is an important source of STEC infections in humans. To emphasize the cattle-to-human transmission through the consumption of contaminated beef in Bishoftu, Ethiopia, whole-genome sequencing (WGS) was performed on E. coli O157 strains isolated from three sources (cattle, beef, and humans). Forty-four E. coli O157:H7 isolates originating from 23 cattle rectal contents, three cattle hides, five beef carcasses, seven beef cuts at retail shops, and six human stools in Bishoftu between June 2017 and May 2019 were included. This study identified six clusters of closely related E. coli O157:H7 isolates based on core genome multilocus sequence typing (cgMLST) by targeting 2513 loci. A genetic linkage was observed among the isolate genomes from the cattle rectal contents, cattle hides, beef carcasses at slaughterhouses, beef at retail shops, and human stool within a time frame of 20 months. All the strains carried practically the same repertoire of virulence genes except for the stx2 gene, which was present in all but eight of the closely related isolates. All the strains carried the mdfA gene, encoding for the MdfA multi-drug efflux pump. CgMLST analysis revealed genetically linked E. coli O157:H7 isolates circulating in the area, with a potential transmission from cattle to humans through the consumption of contaminated beef and beef products. Full article

Main circulation pump is the only high-speed rotating equipment in primary loop of nuclear power plant. Its function is to ensure the normal operation of primary loop system by controlling the circulating flow of reactor coolant. In order to ensure long-term healthy operation of nuclear power main circulating pump, a method for identifying the health states of nuclear power main circulating pump based on ensemble empirical mode decomposition (EEMD) and support vector machine optimized by optimized quantum genetic algorithm (OQGA-SVM) is proposed. Vibration signal of main circulating pump is decomposed by EEMD. Vibration signal characteristics of nuclear power main circulating pump in healthy state and different fault states are analyzed and target characteristic indexes are put forward. Then, health state identification model of main circulation pump of OQGA-SVM is established, and target characteristic indexes are used as input parameter of the model. Finally, combined with experimental data, the model analysis and validation show that the health state identification method of nuclear power main circulating pump based on EEMD-OQGA-SVM can accurately and effectively identify the states of main circulation pump, has a higher identification accuracy than EEMD-SVM method and is more efficient and accurate than EEMD-QGA-SVM method. Full article

Hemorrhagic shock (HS) management is based on a timely, rapid, definitive source control of bleeding/s and on blood loss replacement. Stopping the hemorrhage from progressing from any named and visible vessel is the main stem fundamental praxis of efficacy and effectiveness and an essential, obligatory, life-saving step. Blood loss replacement serves the purpose of preventing ischemia/reperfusion toxemia and optimizing tissue oxygenation and microcirculation dynamics. The “physiological classification of HS” dictates the timely management and suits the ‘titrated hypotensive resuscitation’ tactics and the ‘damage control surgery’ strategy. In any hypotensive but not yet critical shock, the body’s response to a fluid load test determines the cut-off point between compensation and progression between the time for adopting conservative treatment and preparing for surgery or rushing to the theater for rapid bleeding source control. Up to 20% of the total blood volume is given to refill the unstressed venous return volume. In any critical level of shock where, ab initio, the patient manifests signs indicating critical physiology and impending cardiac arrest or cardiovascular accident, the balance between the life-saving reflexes stretched to the maximum and the insufficient distal perfusion (blood, oxygen, and substrates) remains in a liable and delicate equilibrium, susceptible to any minimal change or interfering variable. In a cardiac arrest by exsanguination, the core of the physiological issue remains the rapid restoration of a sufficient venous return, allowing the heart to pump it back into systemic circulation either by open massage via sternotomy or anterolateral thoracotomy or spontaneously after aorta clamping in the chest or in the abdomen at the epigastrium under extracorporeal resuscitation and induced hypothermia. This is the only way to prevent ischemic damage to the brain and the heart. This is accomplishable rapidly and efficiently only by a direct approach, which is a crush laparotomy if the bleeding is coming from an abdominal +/− lower limb site or rapid sternotomy/anterolateral thoracotomy if the bleeding is coming from a chest +/− upper limbs site. Without first stopping the bleeding and refilling the heart, any further exercise is doomed to failure. Direct source control via laparotomy/thoracotomy, with the concomitant or soon following venous refilling, are the two essential, initial life-saving steps. Full article

NorA is one of the main native MDR efflux pumps of Staphylococcus aureus, contributing to reduced susceptibility towards fluoroquinolones and biocides, but little is known about its variability within S. aureus or its distribution and conservation among other staphylococci. We screened for sequences homologous to S. aureus norA and found it in 61 out of the 63 Staphylococcus species described. To the best of our knowledge, this is the first study to report the occurrence of norA across the Staphylococcus genus. The norA phylogenetic tree follows the evolutionary relations of staphylococci and the closely related Mammalliicoccus genus. Comparative analyses suggest a conservation of the NorA function in staphylococci. We also analyzed the variability of norA within S. aureus, for which there are several circulating norA alleles, differing up to 10% at the nucleotide level, which may hamper proper norA detection. We demonstrate the applicability of a PCR-based algorithm to detect and differentiate norA alleles in 52 S. aureus representing a wider collection of 89 isolates from different hosts. Our results highlight the prevalence of norAI and norAII in different settings and the association of norA alleles with specific S. aureus clonal lineages. Ultimately, it confirms the applicability of our PCR-based algorithm to rapidly detect and assign the different norA alleles, a trait that may impact antimicrobial efflux capacity and the search for potential NorA inhibitors. Full article

This paper takes the bottom pumping roadway of 33190 machine roadway in the No.10 mine of China PingMeiShenMa Group as the engineering background. This mine is a hydrothermal mine, with strong heat conduction and thermal convection activities between the surrounding rock and geothermal water. This forms a geothermal anomaly area, making the overall temperature of the surrounding rock temperature field increase and affecting the mine thermal environment. According to the measured field data and the engineering geological conditions of the roadway, a roadway seepage-heat transfer model is constructed using the comsol numerical simulation software, emulating the effect of geothermal water upwelling to the roadway through random cracks in the surrounding rock at different temperatures and pressures, which has an impact on the airflow temperature field of the roadway. The study shows that the evolution law of the airflow temperature field in the roadway under different water upwelling temperatures and pressures is roughly the same, and the temperature at the entrance of the roadway is almost unchanged: the heating rate is 0, and then increases linearly. The variation in the airflow outlet temperature is analyzed, both under the conditions of same temperature but different pressure, and under the same pressure but different temperature. The water upwelling temperature and the cooling efficiency are positively correlated, and the overall growth rate of the airflow temperature is positively correlated with the water upwelling temperature and pressure; however, the effect of temperature is far greater than that of pressure. The upwelling temperature of geothermal water is the main influencing factor on the temperature field of the airflow in the roadway. Therefore, it is possible to reduce the temperature of upwelling water by laying heat insulation materials on the bottom plate, evacuating geothermal water and circulating cold-water by injection, so as to improve the thermal environment of water-heated mines and increase their production efficiency. Full article