Search Results (72)

Microplastics are pervasive environmental pollutants that pose risks to human health through ingestion and inhalation. This review synthesizes current practices to reduce exposure and toxicity by examining major exposure routes and dietary interventions. More than 130 papers were analyzed to achieve this aim. The findings show that microplastics contaminate a wide range of food products, with particular concern over seafood, drinking water, plastic-packaged foods, paper cups, and tea filter bags. Inhalation exposure is mainly linked to indoor air quality and smoking, while dermal contact poses minimal risk, though the release of additives from plastics onto the skin remains an area of concern. Recommended strategies to reduce dietary exposure include consuming only muscle parts of seafood, moderating intake of high-risk items like anchovies and mollusks, limiting canned seafood liquids, and purging mussels in clean water before consumption. Avoiding plastic containers, especially for hot food or microwaving, using wooden cutting boards, paper tea bags, and opting for tap or filtered water over bottled water are also advised. To mitigate inhalation exposure, the use of air filters with HyperHEPA systems, improved ventilation, regular vacuuming, and the reduction of smoking are recommended. While antioxidant supplementation shows potential in reducing microplastic toxicity, further research is needed to confirm its effectiveness. This review provides practical, evidence-based recommendations for minimizing daily microplastic exposure. Full article

Nitazenes represent an emerging class of new synthetic opioids characterized by a high-potency μ-opioid receptor (MOR) agonist activity. Background: We report two 20-year-old males who presented with severe neurorespiratory depression with typical opioid syndrome, but no opioid identification based on routine blood and urine screening tests. The first patient recovered with supportive care, mechanical ventilation, and naloxone infusion, whereas the second patient developed post-anoxic cardiac arrest and died from brain death. Methods: A complementary comprehensive toxicological screening using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) was performed, and data were processed using a dedicated molecular network strategy to profile the metabolites. Results: Protonitazene and protonitazepyne, two nitazenes differing in their ethylamine moieties (i.e., a diethyl versus a pyrrolidine substitution, respectively), were identified. We found an extensive metabolism of protonitazene, leading to the identification of multiple phase I (resulting from hydroxylation, N-desethylation, and O-despropylation) and phase II (resulting from glucuronidation) metabolites. By contrast, protonitazepyne metabolism appeared limited, with one metabolite annotated confidently, protonitazepyne acid, which resulted from the oxidative pyrrolidine ring cleavage. Concusions: To conclude, nitazene detection is highly challenging due to its extensive structural and metabolic diversity. Our findings highlight the contribution of the untargeted LC-HRMS screening approach and suggest that diagnostic product ions can serve as robust markers for nitazene identification. Full article

With the rapid expansion of methanol-powered shipping, the emphasis within the industry has increasingly been placed on ensuring the operational safety of these alternative fuel vessels. In this study, the mixture and realizable k-ε models are adopted to simulate the liquid methanol leakage model, and the predictive accuracy of the model is verified through a comparative analysis with experimental results. Given the complexity of ship cabins, a comprehensive exploration of the leakage and diffusion behaviors of methanol under different ambient temperatures, main engine surface temperatures, and leakage port sizes is conducted. The research findings show that an increase in ambient temperature significantly accelerates vapor diffusion by enhancing evaporation and strengthening the wall-accumulation effect. In contrast, an increase in the main engine surface temperature mainly causes local vapor stagnation and has a relatively limited impact on the overall diffusion pattern. An increase in the leakage orifice diameter directly increases the leakage volume, shortens the diffusion period, and promotes nonlinear growth of the vapor height. The research results can not only provide a theoretical basis for the design of cabin structures and ventilation systems of methanol fuel ships but also be applied to the risk prevention and control of methanol leakage scenarios on ships. Full article

ARDS is a challenging syndrome in which the hallmark is alveolar epithelium damage, with the consequent extravasation of fluids into the interstitium and alveolar space. Patients with severe ARDS almost always require mechanical ventilation and aggressive fluid resuscitation, at least in the initial phases. The increased intrathoracic pressure during positive pressure ventilation reduces cardiac output, worsening the circulatory status of these patients even more. In this pathological context, fluid therapies serve as a means to restore intravascular volume but can simultaneously play a detrimental role, increasing the amount of liquid in the lungs and worsening gas exchange and lung mechanics. Indeed, clinical research suggests that fluid overload leads to worsening outcomes, mostly in terms of gas exchange, days of mechanical ventilation, and ICU stay duration. For these reasons, this review aims to provide basic information about ARDS pathophysiology and heart–lung interactions, the understanding of which is essential to guide fluid therapy, together with the close monitoring of hemodynamics and fluid responsiveness. Full article

(1) Background: Traditionally, hop is propagated using rhizome fragments or herbaceous stem cuttings. Micropropagation, therefore, offers a viable alternative for the large-scale production of healthy, genetically uniform plants, regardless of the season and within confined spaces. A temporary immersion system (TIS) facilitates plant propagation by alternating immersions of microcuttings in liquid culture medium with dry periods, preventing gas accumulation through forced ventilation. (2) Methods: In this study, the response of hop plantlets, cv. Columbus, cultured in media with and without sucrose, in solid and liquid culture systems (Plantform^TM bioreactor), was evaluated, considering its effect on morpho-physiological parameters, on the total phenolic content, and on antioxidant capacity. Moreover, to make the TIS more efficient, the effect of immersion duration (three and six minutes every twelve hours) was evaluated. (3) Results: The presence of sucrose in the culture medium improved plant proliferation in both culture systems tested: solid and liquid (particularly for explants immersed for three minutes). In the TIS, plantlets with a higher antioxidant capacity were obtained when sucrose-free culture medium was used. (4) Conclusions: This study confirms the efficacy of the TIS as a hop propagation method but also as a valid tool to produce biomass to be used as a source of bioactive compounds. Full article

This article analyses the use of low-temperature PCMs in devices supplementing a room ventilation system to prevent the overcooling effect. In this study, the phase change is numerically simulated in an axisymmetric system consisting of two tubes. One is filled with RT11HC with an initial temperature of 0 °C, while air with an inlet temperature of 20 °C flows through the other, heating the PCM and causing it to melt. Calculations are performed using commercial software with the apparent heat method for a system of given dimensions. Spatial distributions of the system temperature and liquid volume fraction at different time moments (from 0 to 120 min) are determined. It is found that the results depended mainly on the method of determining the latent heat. For the beginning of the charging process (t < 40 min), the values of the liquid phase fraction determined by the H and S methods are similar, while the one determined by the G method is definitely higher (even three times at t = 10 min). In turn, the outlet air temperature determined by the S method is lower than that determined by the other methods. The size and shape of the mesh have no significant effect on the results. Full article

In view of the current situation where research on the dust diffusion laws of different dust source points is limited and the gap with the actual field situation is too large; this study employs an innovative gas–liquid–solid triphase coupling method to investigate how dust moves and spreads in the fully mechanized excavation face 431305 at the Liangshuijing Mine; focusing on both the dust field and the dust–fog coupled field. The results indicate that using the long-pressure short-suction ventilation method; dust movement in the roadway is primarily influenced by the airflow; which can be classified into vortex; jet; and return flow regions. The analysis reveals that different dust source points affect dust distribution patterns. Dust source 1 generates the highest dust concentration; primarily accumulating on the duct side and return air side of the roadway. By contrast; dust source 2’s dust mainly gathers at the heading and the front of the cutting head. Dust sources 3 and 4 show lower dust concentrations near the top of the roadway. Dust source 5 achieves the most effective dust removal; aided by airflow and a suction fan; showcasing superior dust performance. A comprehensive comparison indicates that dust source 1 has the highest overall dust concentration. Therefore; further simulation of the distribution law of dust generated at dust source 1 under the action of water mist reveals that the dust concentration near the heading face is reduced from 2000 mg/m³ under the action of single air flow to about 1100 mg/m³. At t = 5 s; the spray droplets almost cover the entire tunneling face; leading to a significant decrease in dust concentration within 10–25 m from the tunneling face. Within 40 s; both coal dust and spray droplets are significantly reduced. The field measurement results verify the accuracy of the simulation results and provide certain guidance for promoting the sustainable development of the coal industry. Full article

This study aims to explore the diagnostic potential of blood lipid profiles in suspected ventilator-associated pneumonia (VAP). Early detection of VAP remains challenging for clinicians due to subjective clinical criteria and the limited effectiveness of current diagnostic tests. Blood samples from 20 patients, with ages between 6 months and 15 years, were collected at days 1, 3, 6, and 12, and an untargeted lipidomics analysis was performed using a Ultra high Pressure Liquid Chromatography hyphenated with High Resolution Mass Spectrometry UPLC-HRMS (TIMS-TOF/MS) platform. Patients were stratified based on modified pediatric clinical pulmonary index score (mCPIS) into high (mCPIS ≥ 6, n = 12) and low (mCPIS < 6, n = 8) VAP suspicion groups. With the untargeted lipid profiling, we were able to identify 144 lipid species from different lipid groups such as glycerophospholipids, glycerolipids, and sphingolipids, in the blood of children with VAP. Multivariate and univariate statistical analyses revealed a distinct distribution of blood lipid profiles between the studied groups, indicating the potential utility of lipid biomarkers in discriminating VAP presence. Additionally, specific lipids were associated with pharyngeal culture results, notably the presence of Klebsiella pneumoniae and Staphylococcus aureus, underscoring the importance of lipid profiling in identifying the microbial etiology of VAP. Full article

This paper presents the continuation of experimental investigations conducted by the present authors to measure and compare the thermal and fluid dynamic performance of a residential hydronic air coil using nanofluids. The prior experiments were limited to testing only one volumetric concentration (1%) of aluminum oxide (Al₂O₃) nanofluid. They compared it with the base fluid, a 60% ethylene glycol/40% water mixture by mass (60% EG). The original tests revealed some deficiencies in the experimental setup, which was subsequently revised and improved. This paper summarizes the results of experiments from the improved test bed using three concentrations of Al₂O₃ nanofluids: 1, 2, and 3% volumetric concentrations prepared with an average particle size of 45 nm in a 60% EG dispersion. The test bed in these experiments simulates a small air handling system typical of heating, ventilation, and air conditioning (HVAC) applications in cold regions. Entering conditions for the air and liquid were selected to emulate typical commercial air handling systems operating in cold climates. Contrary to previous findings, our test results revealed that nanofluids did not perform as well as expected. Prior predictions from many analytical and numerical studies had promised significant performance gain. The performance of the 1% nanofluid was generally equal to that of the base fluid under identical inlet conditions. However, the performance of the 2% and 3% nanofluids was considerably lower than that of the base fluid. The higher concentration nanofluids exhibited heat rates up to 14.6% lower than the 60% EG and up to 44.3% lower heat transfer coefficient. The 1% Al₂O₃/60% EG exhibited a 100% higher pressure drop across the coil than the base fluid, considering equal heat output. This performance degradation was attributed to the inability to maintain nanofluid dispersion stability, agglomeration, and subsequent decline in the thermophysical properties. Full article

Disposal tunnels in geological repositories are ventilated continuously for over 50 years until their closure. Under these conditions, an unsaturated zone of mixed liquid and gas phases forms around the tunnels. Moreover, drying is assumed to progress from the host rock to the tunnels. To understand these drying processes, this study investigated the migration and precipitation of solutes via capillary forces during drying in packed columns using silica sand or glass beads as packed layers and X-ray CT analysis. In addition, the apparent permeability of a column packed with silica sand containing precipitation was examined using a flow experiment. The results indicate that the precipitation and accumulation of solutes were significant near the drying surfaces of the columns. The apparent mass transfer coefficient at a relatively early stage of the drying process indicates that the migration rate of solutes depends strongly on the capillary forces during the drying process. Furthermore, the apparent permeability of the columns with precipitation decreased significantly. These indicate that the precipitation and accumulation of solutes with drying in the groundwater reduce the porosity and permeability, and the advection of groundwater around the repository may be suppressed. Full article

Growth environment greatly alters many facets of pathogen physiology, including pathogenesis and antimicrobial tolerance. The importance of host-mimicking environments for attaining an accurate picture of pathogen behaviour is widely recognised. Whilst this recognition has translated into the extensive development of artificial cystic fibrosis (CF) sputum medium, attempts to mimic the growth environment in other respiratory disease states have been completely neglected. The composition of the airway surface liquid (ASL) in different pulmonary diseases is far less well characterised than CF sputum, making it very difficult for researchers to model these infection environments. In this review, we discuss the components of human ASL, how different lung pathologies affect ASL composition, and how different pathogens interact with these components. This will provide researchers interested in mimicking different respiratory environments with the information necessary to design a host-mimicking medium, allowing for better understanding of how to treat pathogens causing infection in these environments. Full article

Fugitive methane emissions from the mining industry, particularly so-called ventilation air methane (VAM) emissions, are considered among the largest sources of greenhouse gas (GHG) emissions. VAM emissions not only contribute to the global warming but also pose a significant hazard to mining safety due to the risk of accidental fires and explosions. This research presents a novel approach that investigates the capture of CH₄ in a controlled environment using 1-butyl-3-methylimidazolium bis (trifluoromethylsulfonyl) imide [BMIM][TF₂N] ionic liquid (IL), which is an environmentally friendly solvent. The experimental and modelling results confirm that CH₄ absorption in [BMIM][TF2N], in a packed column, can be a promising technique for capturing CH₄ from point sources, particularly the outlet streams of ventilation shafts in underground coal mines, which typically accounts for <1% v/v of the flow. This study assessed the effectiveness of CH₄ removal in a packed bed column by testing various factors such as absorption temperature, liquid and gas flow rates, flow pattern, packing size, desorption temperature, and desorption pressure. According to the optimisation results, the following parameters can be used to achieve a CH₄ removal efficiency of 23.8%: a gas flow rate of 0.1 L/min, a liquid flow rate of 0.5 L/min, a packing diameter of 6 mm, and absorption and desorption temperatures of 303 K and 403.15 K, respectively. Additionally, the experimental results indicated that ILs could concentrate CH₄ in the simulated VAM stream by approximately 4 fold. It is important to note that the efficiency of CH₄ removal was determined to be 3.5-fold higher compared to that of N₂. Consequently, even though the VAM stream primarily contains N₂, the IL used in the same stream shows a notably superior capacity for removing CH₄ compared to N₂. Furthermore, CH₄ absorption with [BMIM][TF₂N] is based on physical interactions, leading to reduced energy requirements for regeneration. These findings validate the method’s effectiveness in mitigating CH₄ emissions within the mining sector and enabling the concentration of VAM through a secure and energy-efficient procedure. Full article

This study evaluated the effects of different drying techniques on the physicochemical properties of Pleurotus citrinopileatus Singer (P. citrinopileatus), focusing on the ergothioneine (EGT) contents. The P. citrinopileatus was subjected to natural ventilation drying (ND), freeze-drying (FD), and hot-air drying (HD). EGT was extracted using high-hydrostatic-pressure extraction (HHPE), and response surface methodology (RSM) was employed with four variables to optimize the extraction parameters. The crude EGT extract was purified by ultrafiltration and anion resin purification, and its antioxidant activity was investigated. The results showed that the ND method effectively disrupted mushroom tissues, promoting amino acid anabolism, thereby increasing the EGT content of mushrooms. Based on RSM, the optimum extracting conditions were pressure of 250 MPa, extraction time of 52 min, distilled water (dH₂O) as the extraction solvent, and a 1:10 liquid–solid ratio, which yielded the highest EGT content of 4.03 ± 0.01 mg/g d.w. UPLC-Q-TOF-MSE was performed to assess the purity of the samples (purity: 86.34 ± 3.52%), and MS² information of the main peak showed primary ions (m/z 230.1) and secondary cations (m/z 186.1050, m/z 127.0323) consistent with standard products. In addition, compared with ascorbic acid (VC), EGT showed strong free radical scavenging ability, especially for hydroxyl and ATBS radicals, at more than 5 mmol/L. These findings indicate that the extraction and purification methods used were optimal and suggest a possible synthetic path of EGT in P. citrinopileatus, which will help better explore the application of EGT. Full article

This study focuses on advancing sweat management in clothing using low-current operating textile electroosmotic pumps, which could be beneficial for microenvironments with restricted ventilation, such as the one between the skin and protective wear. These systems, employing silver–copper fabric electrodes, a polycarbonate membrane with microchannels, and an adhesive web, enabled directed liquid transport. The critical role of the adhesive layer preparation is emphasized, often overlooked in previous research. Various adhesive perforations were tested for their impact on the flow under current action, both with and against gravity. Specific adhesive application techniques are proposed, found to significantly influence the flow rate and textile assembly cohesion. The custom setup yielded flow rates of up to 8.8 ± 0.08 mg min⁻¹ cm⁻², suitable for diverse human sweat rates. Optimization hinges on the delicate balance between binding and the active surface areas of the adhesive. Full article

The aim of the research is to assess changes in odour concentration in the ventilated air of a production hall, using different types of biofilter fillings and different types of membranes. Deodorisation was carried out using a mobile combined biofilter at a plant producing lard and liquid oils. Ventilated air from the hall contained organic and inorganic pollutants. Two types of fillings were used for technological tests: stumpwood chips mixed with pine bark and a mix of stumpwood chips with pine bark and green waste compost. Two types of membranes were also used, differing in thickness, permeability, and water resistance. The subjects of the research were the air supplied to the filter, lifted directly from the bed, and the air above the membranes. The deodorisation efficiency—the percentage reduction in the odour concentration value as a result of air flow through the bed and membranes—was calculated. The filtration methods used allowed the selection of the most advantageous technological variant from the point of view of deodorisation effectiveness: a mix of stumpwood chips with pine bark and the Pro Eko Tex UV membrane. It has a total odour reduction efficiency of 99.3–99.9% and has been added to full-scale implementation works. Full article