Search Results (23)

Pedicle screw malpositioning remains a frequent complication, with reported rates from 2% to 15%, often leading to revision surgeries. Analyzing mechanical resistance and torque encountered during screw insertion has been implicated as a promising approach for real-time detection. Five fresh-frozen human thoracolumbar spine specimens were utilized in this study. Using 3D-printed templates, correct trajectories were systematically compared against four defined malpositions (medial, lateral, superior, superolateral), with offsets ranging from 2.0 mm to 3.5 mm. Drilling, tapping, and insertion phases were conducted at a constant speed and defined feed force. Contrary to the anticipated behavior, malpositioned trajectories showed no statistically significant difference in peak torque compared to correct trajectories across all phases (e.g., tapping $p=0.944$, $r=0.01$; insertion $p=0.693$, $r=0.05$). Regional stratification between thoracic and lumbar spine also failed to yield significant differences. The only statistically significant difference was observed between the correct trajectory and the superolateral malposition during drilling ($p=0.038$). Under the tested standardized conditions, torque-based mechanical resistance during pedicle screw placement is generally not a reliable and consistent real-time indicator of malposition. Full article

Background/Objectives: Umbilical venous catheters (UVCs) and umbilical artery catheters (UACs) are essential for neonatal care, facilitating medication delivery, nutritional support, and blood pressure monitoring. However, malposition and prolonged catheter dwell time can lead to severe complications, including central line-associated bloodstream infections (CLABSIs). This study aims to evaluate the benefits of ultrasound in confirming catheter tip location, which may impact infection risk, and to assess the effectiveness of modification of the securing method. Methods: This prospective randomized controlled study was conducted from May 2022 to December 2024 at an NICU in Taiwan. Neonates requiring umbilical catheters were randomly assigned to three groups. In Group 1, the catheter length was calculated using a formula, X-ray confirmation was used, and the catheter was secured with traditional tape. In Group 2, ultrasound confirmation was used and the catheter was secured with FoamLite™ sterile dressing and transparent film. In Group 3, ultrasound confirmation was used and the catheter was secured with traditional tape. The outcomes were the rate of complications of the catheters. Results: Groups 2 and 3 demonstrated significantly lower malposition rates, microbial colonization, and CLABSI incidence compared to Group 1 (p = 0.001, 0.006, and 0.026, respectively). No significant difference was observed between Groups 2 and 3, suggesting that accurate tip positioning was more influential in reducing CLABSIs than the securing method itself. Conclusions: Ultrasound guidance improves catheter placement accuracy, minimizes malposition, lowers CLABSI risk, and reduces radiation exposure, supporting its broader implementation in NICUs. Full article

In less than 30 years, Deep Brain Stimulation (DBS) has evolved from an antiparkinsonian rescue intervention into a flexible neuromodulatory therapy with the potential for personalized, adaptive, and enhancement-focused interventions. In this review we collected evidence from seven areas: (i) modern eligibility criteria, and ways to practically improve on these, outside of ‘Core Assessment Program of Surgical Interventional Therapies in Parkinson’s Disease’ (CAPSIT-PD); (ii) cost-effectiveness, where long-horizon models now show positive incremental net monetary benefit for Parkinson’s disease, and rechargeable-devices lead the way in treatment-resistant depression and obsessive–compulsive disorder; (iii) anatomical targets, from canonical subthalamic nucleus (STN) / globus pallidus internus (GPi) sites, to new dual-node and cortical targets; (iv) mechanistic theories from informational lesions, antidromic cortical drive, and state-dependent network modulation made possible by optogenetics and computational modeling; (v) psychiatric and metabolic indications, and early successes in subcallosal and nucleus-accumbens stimulation for depression, obsessive–compulsive disorder (OCD), anorexia nervosa, and schizophrenia; (vi) procedure- and hardware-related safety, summarized through five reviews, showing that the risks were around 4% for infection, 4–5% for revision surgery, 3% for lead malposition or fracture, and 2% for intracranial hemorrhage; and (vii) future directions in connectomics, closed-loop sensing, and explainable machine learning pipelines, which may change patient selection, programming, and long-term stewardship. Overall, the DBS is entering a “third wave” focused on a better understanding of neural circuits, the integration of AI-based adaptive technologies, and an emphasis on cost-effectiveness, in order to extend the benefits of DBS beyond the treatment of movement disorders, while remaining sustainable for healthcare systems. Full article

Objective: The insertion of venous catheters into supra-aortic vessels is a standard procedure in the treatment of a large number of diseases. Incorrect placement of venous catheters into and accidental perforation of arterial vessels is a rare but serious complication that can lead to severe bleeding, dissections, and strokes. Materials and Methods: We present a case of iatrogenic malposition of a Broviac catheter into the right vertebral artery and its successful treatment through stenting of the perforation site using a Walrus balloon catheter to achieve a secure treatment position and eventually cover the perforation site. Additionally, we conducted a systematic literature review on endovascular rescue procedures in inadvertent injuries of the supra-aortic arteries related to venous catheter placement. Results: A balloon guide catheter was used to achieve a secure treatment position for the deployment of a stent graft covering the perforation site, ensuring no significant arterial hemorrhage occurred during the removal of the incorrectly placed Broviac catheter. The review of the literature on endovascular rescue procedures for supra-aortic arterial vessel damage caused by venous catheter placement revealed that endovascular treatment has been successful in all reported cases of catheter-related supra-aortic arterial injury. Primary stent graft placement without additional actions was the most common treatment approach. Conclusions: In the treatment of iatrogenic injuries to the supra-aortic vessels, endovascular treatment strategies represent a safe, reliable, and generally recognized option and thus are used much more frequently than surgical procedures. Key point: In rare cases of accidental malposition of venous catheters into supra-aortic arterial vessels, endovascular insertion of a stent graft covering the perforation site using a balloon guide catheter can be a safe treatment option. Full article

Background: Supplemental teeth are a rare subtype of supernumerary elements that closely resemble the morphology of normal dentition. Their occurrence in the mandibular anterior region is extremely uncommon. Aim: To describe the clinical features, diagnosis, and phased orthodontic management of a rare case involving bilateral supplemental mandibular incisors in a pediatric patient. Case report: A 7-year-old female patient presented with early mixed dentition and significant lower anterior crowding due to the presence of two fully erupted supplemental mandibular incisors. Treatment phase I included extraction of the malpositioned supplemental teeth and rapid maxillary expansion to transversally coordinate the arches. By the end of phase I, spontaneous alignment of the remaining lower incisors was observed. Discussion: The presence of two supplemental mandibular incisors is extremely rare in Caucasian populations. Supernumerary teeth can cause crowding, impaction, or delayed eruption of adjacent permanent teeth. Timely extraction can prevent such complications and often allows spontaneous alignment. Conclusions: The prompt removal of supplemental mandibular incisors, when they have just erupted, might lead to the alignment of the other incisors, considering that they spontaneously occupy the extractive spaces often without the aid of fixed appliances first line. Full article

This study investigates the occurrence of dystocia in sheep farming, particularly focusing on the Batna region in eastern Algeria. Dystocia, or difficulty in parturition, represents a significant economic challenge, contributing to high perinatal mortality rates, maternal death, and reduced reproductive efficiency in sheep. This study aimed to identify the primary causes and risk factors associated with dystocia through surveys conducted with local veterinarians. The research findings suggest that fetal malposition, fetal oversize, and incomplete cervical dilation are the leading causes of dystocia. Additionally, maternal factors such as incomplete cervical dilation and uterine torsion were also a common cause. The risk of dystocia increases with parity and litter size and decreases with body score. Early veterinary intervention, including cesarean sections, reduced lamb mortality and greatly improved reproductive outcomes. These findings underline the importance of effective management strategies in preventing and managing dystocia in sheep farming. Full article

Background: Peripherally inserted central catheters (PICCs) are becoming an increasingly utilised alternative to traditional central venous access devices. Their uptake, particularly among oncology patients, is due to their growing ease of access, suitability for medium-term use and perceived safety profile. However, PICCs can be a source of severe and life-threatening complications such as central line-associated bloodstream infection (CLABSI), deep vein thrombosis (DVT), pulmonary embolism (PE), malpositioning, dislodgement, and occlusion. Methods: This narrative was constructed from a literature review of the PubMed database, utilising MESH terms for peripherally inserted central catheters, percutaneous central catheters, PICC, and complications. Randomised controlled trials, systematic reviews, and meta-analyses published between 2015 and 2025 were included. Additional articles were obtained through targeted PubMed searches or from references within previous articles. Results: Major periprocedural complications were seen in 1.1% of PICC insertions, CLABSI in 1.4–1.9%, venous thrombosis embolism (including PE) in 2.3–5.9%, and malpositioning in 7.87%. The overall PICC complication incidence was 9.5–38.6%, which is greater than that of centrally inserted central venous access. A higher BMI, diabetes mellitus, chronic renal failure, and malignancy were the most significant predictive factors for PICC-associated complications. Conclusions: PICC complications are common, occurring more frequently than other forms of central venous access, and may lead to significant morbidity and mortality. Appropriate assessment of patient risk factors and optimisation strategies may reduce complication rates. Full article

Background/Objectives: The management of ocular tumors often necessitates surgery, either alone or in combination with radiotherapy, chemotherapy, or other modalities. While crucial for tumor control, these treatments can significantly impact the ocular surface, leading to both acute and chronic complications. This review examines iatrogenic ocular surface diseases resulting from oncologic interventions, emphasizing their pathophysiology, diagnostic challenges, and management strategies. Methods: A literature review was conducted to identify studies on iatrogenic ocular surface complications associated with ocular tumor treatments. Results: Ocular surface complications include direct damage from surgical manipulation, leading to corneal opacities and persistent epithelial defects, as well as dry eye disease secondary to postoperative chemosis. These disruptions may progress to more severe conditions such as keratopathy, corneal ulcers, limbal stem cell deficiency, and stromal scarring, further impairing visual function. Structural alterations contribute to eyelid malpositions—including ectropion, entropion, round eye, and lagophthalmos—which exacerbate exposure-related damage and ocular surface instability. In cases of uveal melanomas, the exposure of episcleral brachytherapy plaques can induce chronic conjunctival irritation, promoting adhesion formation and symblepharon. Surgical interventions disrupt ocular surface homeostasis, while radiotherapy and chemotherapy exacerbate these effects through cytotoxic and inflammatory mechanisms. Conclusions: Preventing and managing iatrogenic ocular surface complications require a multidisciplinary approach involving early diagnosis, personalized treatment strategies, and targeted postoperative care. Comprehensive pre- and postoperative planning is essential to optimize both visual function and long-term ocular surface integrity, ultimately ensuring a balance between oncologic control with functional and aesthetic preservation. Full article

Background/Objectives: Few studies report on hip rotation after total hip arthroplasty (THA); however, details of the factors affecting the hip rotation angle are unknown. We aimed to investigate the factors related to hip rotation after THA. Methods: This study included 124 consecutive patients who underwent THA. We retrospectively analyzed the correlation between changes in the rotation angle of the femur relative to the pelvis, global femoral offset, and femoral version and leg lengthening. Moreover, we performed a multivariate regression analysis of these parameters to calculate the efficacy of the change in the rotation angle of the femur relative to the pelvis. Results: Leg lengthening and femoral version change were negatively correlated, whereas change in global femoral offset was positively correlated with leg lengthening, with correlation coefficients of 0.376, 0354, and 0.334, respectively. Regarding the multiple regression analysis, only leg lengthening was correlated with the change in rotation angle of the femur relative to the pelvis, with a coefficient of −0.336. Conclusions: The change in the rotation angle of the femur relative to the pelvis is only associated with leg lengthening in multivariate analysis. In actual planning, in cases where the hip is internally rotated, it may be better not to excessively increase leg length, decrease anterior stem anteversion, or increase global femoral offset. Thus, physicians should avoid large leg lengthening for patients with highly external rotation in their hip joint as it may lead to increased internal rotation of the hip, consequently resulting in relative malpositioning and subsequent implant impingement and/or dislocation following THA. Full article

Objective: In spine surgery, ensuring the safety of vital structures is crucial, and various instruments contribute to the surgeon’s confidence. This study aims to present outcomes from spinal cases operated on using the freehand technique and neuronavigation with an O-arm in our clinic. Additionally, we investigate the impact of surgical experience on outcomes by comparing early and late cases operated on with neuronavigation. Method: We conducted a retrospective analysis of spinal patients operated on with the freehand technique and neuronavigation in our clinic between 2019 and 2020, with a minimum follow-up of 2 years. Cases operated on with neuronavigation using the O-arm were categorized into early and late groups. Results: This study included 193 patients, with 110 undergoing the freehand technique and 83 operated on utilizing O-arm navigation. The first 40 cases with neuronavigation formed the early group, and the subsequent 43 cases comprised the late group. The mean clinical follow-up was 29.7 months. In the O-arm/navigation group, 796 (99%) of 805 pedicle screws were in an acceptable position, while the freehand group had 999 (89.5%) of 1117 pedicle screws without damage. This rate was 98% in the early neuronavigation group and 99.5% in the late neuronavigation group. Conclusions: The use of O-arm/navigation facilitates overcoming anatomical difficulties, leading to significant reductions in screw malposition and complication rates. Furthermore, increased experience correlates with decreased surgical failure rates. Full article

Background: Central venous catheters (CVCs) are indispensable tools in intensive care and emergency medicine. CVC malpositions still occur frequently and can cause various complications leading to increased patient mortality. A microbubbles test (MBT) can be used to confirm correct CVC positioning. However, there is serious doubt regarding whether the currently applied threshold of a 2 s push-to-bubbles time (PTB time) for rapid atrial swirl sign (RASS) in an MBT is reliable and accurate. The aim of the present study was to prove the quality of a new threshold: 1 s. Methods: Consecutive patients who were admitted to the intensive care unit (ICU) in a German neurological specialist hospital from 1 March 2021 to 20 July 2022 were enrolled. After ultrasound-guided CVC insertion, an MBT was performed, PTB time was measured, and RASS was interpreted. Additionally, a chest X-ray (CXR) was requested to check CVC position. Results: A total of 102 CVCs (98% jugular and 2% subclavian) were inserted in 102 patients (38% female and 62% male; median age: 66 years). Negative RASS (PTB time > 1 s) was observed in 2 out of 102 patients, resulting in an echocardiographic malposition rate of 2.0%. CXR confirmed the echocardiographic results. After correcting CVC position in the initially malpositioned CVCs, the PTB time was <1 s (positive RASS). The MBT protocol took about 0.5 min on average, while the CXR results were all available within 30 min. Sensitivity, specificity, and positive and negative predictive value were each 100% for the detection of CVC malpositions via an MBT using a threshold of 1 s compared to CXR. Conclusions: A new threshold of a 1 s PTB time for RASS in an MBT could detect CVC malpositions with excellent quality compared to CXR. Since the MBT was fast and safe and could be performed at the bedside, we propose that an MBT with the new and reliable threshold of 1 s should be routinely used in patient care. Full article

Sacroiliac (SI) joint dysfunction can lead to debilitating pain but can be treated with minimally invasive sacroiliac joint fusion (SIJF). This treatment is commonly performed using 2D fluoroscopic guidance. This makes placing the implants without damaging surrounding neural structures challenging. Virtual surgical planning (VSP) using simulated fluoroscopic images may improve intraoperative guidance. This article describes a workflow with VSP in SIJF using simulated fluoroscopic images and evaluates achieved implant placement accuracy. Ten interventions were performed on 10 patients by the same surgeon, resulting in a total of 30 implants; the median age was 39 years, and all patients were female. The overall mean implant placement accuracy was 4.9 ± 1.26 mm and 4.0 ± 1.44°. There were no malpositioning complications. VSP helped the surgeon understand the anatomy and determine the optimal position and length of the implants. The planned positions of the implants could be reproduced in surgery with what appears to be a clinically acceptable level of accuracy. Full article

Fertility rate and hatchability rate are low for all types of double-yolk (DY) eggs in comparison to single-yolk eggs (SY), but these parameters also depend on the number of developing embryos in the egg. The hatchability rate of double-yolk eggs containing two developing embryos (DY2F) is vastly lower than in the case of double-yolk eggs containing only one embryo (DY1F). The aim of the study was to determine the differences between egg fertility rate, hatchability rate, time of embryonic mortality, and embryo malposition during incubation in three types of eggs from Hy-Line Brown hens: SY, DY1F and DY2F. In addition, the quality of the hatched chicks was assessed using the Pasgar©score. Following a 21-day incubation, chicks were obtained from DY1F and SY eggs. No chicks were obtained from DY2F eggs, although the embryos in these eggs developed up to the late stage of incubation. Early (≤7 d of incubation), middle (8–14 d), and late (≥15 d) embryonic mortality was significantly higher in DY eggs than in SY eggs. The embryonic mortality rate during early incubation was the same for DY1F and DY2F eggs, but middle and late embryonic mortality were significantly higher for DY2F eggs. Based on evaluation of embryo position according to Landauer, only three types of malposition that could potentially lead to embryonic death were noted. There were fewer malpositioned embryos in double-yolk eggs containing one embryo. Quality assessment of chicks (Pasgar©score) showed no differences between chicks hatched from eggs containing one yolk and those hatched from double-yolk eggs with one developing embryo, but chicks from double-yolk eggs were significantly heavier. The results of the research will contribute to a better understanding of the development and mortality of embryos in double-yolk eggs. Full article

Objective: In fetuses with suspicion of congenital heart disease (CHD), assessment by segmental fetal echocardiography is of great importance. This study sought to examine the concordance of expert fetal echocardiography and postnatal MRI of the heart at a high-volume paediatric heart centre. Methods: The data of two hundred forty-two fetuses have been gathered under the condition of full pre- and postnatal and the presence of a pre- and postnatal diagnosis of CHD. The haemodynamically leading diagnosis was determined for each test person and was then sorted into diagnostic groups. The diagnoses and diagnostic groups were used for the comparison of diagnostic accuracy in fetal echocardiography. Results: All comparisons between the diagnostic methods for detection of congenital heart disease showed an “almost perfect” (Cohen’s Kappa > 0.9) strength of agreement for the diagnostic groups. The diagnosis made by prenatal echocardiography showed a sensitivity of 90–100%, a specificity and a negative predictive value of 97–100%, and a positive predictive value of 85–100%. The diagnostic congruence resulted in an “almost perfect” strength of agreement for all evaluated diagnoses (transposition of great arteries, double outlet right ventricle, hypoplastic left heart, tetralogy of Fallot, atrioventricular septal defect). An agreement of Cohen’s Kappa > 0.9 was achieved for all groups, with exception of the diagnosis of double outlet right ventricle (0.8) in prenatal echocardiography compared to postnatal echocardiography. This study came to the result of a sensitivity of 88–100%, a specificity and negative predictive value of 97–100%, and a positive predictive value of 84–100%. The performance of cardiac magnetic resonance imaging (MRI) as an additional measure to echocardiography had an added value in the description of the malposition of the great arteries when diagnosed with double outlet right ventricle and in the detailed description of the anatomy of the lung circulation. Conclusions: Prenatal echocardiography could be shown to be a reliable method for detection of congenital heart disease when regarding the slightly lower accuracy of diagnosis for double outlet right ventricle and right heart anomalies. Furthermore, the impact of examiner experience and the consideration of follow-up examinations for further improvement of diagnosis accuracy may not be underestimated. The main advantage of an additional MRI is the possibility to obtain a detailed anatomic description of the blood vessels of the lung and the outflow tract. The conduction of further studies that include false-negative and false-positive cases, and studies that are not set within the high-risk-group, as well as studies in a less specialized setting, would allow the completion and investigation of possible differences and discrepancies when comparing the results that have been obtained in this study. Full article

During the maintenance period of a future fusion reactor power plant, called DEMOnstration Power Plant (DEMO), remotely handled casks are required to confine and handle DEMO in-vessel components during their transportation between the reactor and the active maintenance facility. In order to limit the dispersion of activated dust, a Contamination Control Door (CCD) is designed to be placed at an interface between separable containments (e.g., vacuum vessels and casks) to inhibit the release of contamination at the interface between them. The remotely operated CCD—technically, a double lidded door system—consists of two separable doors (the cask door and port door) and three different locking mechanisms: (i) between the cask door and cask, (ii) between the cask door and port door and (iii) between the port door and port. The locking mechanisms are selected and assessed according to different criteria, and the structure of the CCD is optimized using an Abaqus Topology Optimization Module. Due to the elastic properties of the CCD, deflections will occur during the lifting procedure, which may lead to malfunctions of the CCD. A test rig is developed to investigate the performance of high-risk components in the CCD in the case of deflections and also malpositioning. Misalignment can be induced along three axes and three angles intentionally to test the single components and items. The aim is to identify a possible range of operating in the case of misalignments. It is expected that the proposed CCD design should be able to operate appropriately in the case of ±3 mm translational misalignments and ±1° rotational misalignments. Full article