Search Results (10)

Small-molecule positive allosteric modulator 1 (SPAM1), which targets pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1-R), has been found to have a neuroprotective effect, and the underlying mechanism was explored in this study. First, using a D-galactose (D-gal)-induced aging mouse model, we confirmed that SPAM1 improves the structure of the hippocampal dentate gyrus and restores the number of neurons. Compared with D-gal model mice, SPAM1-treated mice showed up-regulated expression of Sirtuin 6 (SIRT6) and Lamin B1 and down-regulated expression of YinYang 1 (YY1) and p16. A similar tendency was observed in senescent RGC-5 cells induced by long-term culture, indicating that SPAM1 exhibits significant in vitro and in vivo anti-senescence activity in neurons. Then, using whole-transcriptome sequencing and proteomic analysis, we further explored the mechanism behind SPAM1’s neuroprotective effects and found that SPAM is involved in the longevity-regulating pathway. Finally, the up-regulation of neurofilament light and medium polypeptides indicated by the proteomics results was further confirmed by Western blotting. These results help to lay a pharmacological network foundation for the use of SPAM1 as a potent anti-aging therapeutic drug to combat neurodegeneration with anti-senescence, neuroprotective, and nerve regeneration activity. Full article

Carbon-fiber-reinforced polymer (CFRP) composites are widely used in lightweight structures because of their high specific strength, specific modulus, and low coefficient of thermal expansion. Additionally, the unidirectionally arrayed chopped strand (UACS) laminates have excellent mechanical properties and flowability, making them suitable for fabricating structures with complex geometry. In this paper, the damage process of UACS quasi-isotropic laminates under tensile load was tested using acoustic emission detection technology. The mechanical properties and damage failure mechanism of UACS laminates were studied combined with finite element calculation. By comparing and analyzing the characteristic parameters of acoustic emission signals such as amplitude, relative energy, and impact event, it is found that acoustic emission behavior can accurately describe the damage evolution of specimens during loading. The results show that the high-amplitude signals representing fiber fracture in continuous fiber laminates are concentrated in the last 41%, while in UACS laminates they are concentrated in the last 30%. In UACS laminates, more of the damage is caused by matrix cracks and delamination with medium- and low-amplitude signals, which indicates that UACS laminates have a good suppression effect on damage propagation. The stress–strain curves obtained from finite element analysis agree well with the experiment results, showing the same damage sequence, which confirms that the model described in this research is reliable. Full article

This paper investigates the acoustic radiation characteristics of reinforced laminated cylindrical shell structures in the medium-low frequency range (1~1000 Hz) of aircrafts, submarines, and deepwater thrusters by combining simulation analysis and experimental testing. The research focuses on reinforced laminated plates, where experimental setup is established to measure structural modal parameters and structural acoustic power, and a finite element model is developed to verify the reliability of the finite element modeling method through comparison with experimental and simulation results. Simultaneously, a finite element model of the reinforced laminated cylindrical shell structure is established, and finite element simulation analysis is conducted to investigate the effects of different reinforcement methods, reinforcement quantities, reinforcement lengths, and reinforcement thicknesses on the acoustic radiation characteristics of the structure. The results indicate that in the frequency range of 1~1000 Hz, ribbed reinforcement exhibits better performance in reducing structural noise radiation compared to longitudinal reinforcement. With the increase in reinforcement quantity and thickness, the structural acoustic radiation decreases. Meanwhile, with the increase in reinforcement length, the overall sound power level of the structure shows a trend of first increasing and then decreasing. Full article

Multi-stage hydraulic fracturing (MsHF) is the main technology to improve hydrocarbon recovery from shale plays. Associated with their rich organic contents and laminated depositional environments, shales exhibit transverse isotropic (TI) characteristics. In several cases, the lamination planes are horizontal in shale formations with a symmetric axis that are vertical to the bedding plane; hence, shale formations are known as transverse isotropic vertical (TIV) rocks. Ignoring the TIV nature of shale formations leads to erroneous estimates of in situ stresses and consequently to inefficient designs of fractural geometry, which negatively affects the ultimate recovery. The goal of this study is to investigate the effects of TIV medium characteristics on fractural geometry, spacing, and stress shadow development in the Jurassic Tuwaiq Mountain formation (TMF) in the Jafurah basin, which is a potential unconventional world-class play. This formation is the main source for prolific Jurassic oil reservoirs in Saudi Arabia. On the basis of a petrophysical evaluation in the Jafurah basin, TMF exhibited exceptional unconventional gas characteristics, such as high total organic content (TOC) and low clay content, and it was in the proper maturity window for oil and gas generation. The unconventional Jafurah field covers a large area that is comparable to the size of the Eagle Ford shale play in South Texas, and it is planned for development through multi-stage hydraulic fracturing technology. In this study, analytical modeling was performed to estimate the fractural geometry and in situ stresses in the anisotropic medium. The results show that the Young’s modulus anisotropy had a noticeable impact on fractural width, whereas the impact of Poisson’s ratio was minimal. Moreover, we investigated the impact of stress anisotropy and other rock properties on the stress shadow, and found that a large stress anisotropy could result in fractures being positioned close to one another or theoretically without minimal fractural spacing concerns. Additionally, we estimated the fractural aspect ratio in different propagation regimes and observed that the highest aspect ratio had occurred in the fractural toughness-dominated regime. This study also compares the elastic properties and confirms that TMF exhibited greater anisotropic properties than those of Eagle Ford. These findings have practical implications for field operations, particularly with regard to the fractural geometry and proppant placement. Full article

When encountering sedimentary rocks with obvious laminations or fracture development zones, the conductivity of the conductive medium in different directions will change significantly, and the subsurface medium will exhibit macroscopic conductivity anisotropy. To analyze the impact of electrical anisotropy on the surface–borehole transient electromagnetic exploration method, we used the finite element method to investigate the electrical anisotropy surface–borehole transient electromagnetic three-dimensional (3D) forward algorithm, in which we used a tetrahedral mesh to spatially discretize the time–domain Maxwell equation. Then, we discretized it using the second-order backward Eulerian difference method, and we obtained the fields through the PARDISO solver. The validity and correctness of the algorithm were verified through comparison of a one-dimensional (1D) anisotropic model, a complex three-dimensional (3D) isotropic model, and a three-dimensional (3D) anisotropic half-space model. A typical anisotropic geological model was constructed to analyze the effects of anisotropic strata and anomalies in the different principal axis directions on the surface–borehole transient electromagnetic response. The results show that the response of the anisotropic medium is related to the direction of the transmitting source, and the response pattern is complex and volatile. The electrical anisotropic anomaly does affect the amplitude, which should be given special attention when performing surface–borehole transient electromagnetic inversion interpretation. Full article

Unbonded LRBs (laminated rubber bearings) are commonly applied in small-to-medium-span bridges in China. The frictional sliding characteristics of LRBs have a vital influence on the seismic response of the bridge. Nine square LRBs were subjected to the quasi-static displacement loading test in this paper, and the differences in sliding characteristics of LRBs at the interface of steel and concrete test pad were investigated. The variation of the friction coefficient during sliding was then analyzed. Based on the experimental data, a three-fold mechanical constitutive model of LRBs that considers the breakaway-sliding friction characteristics is established. Further, the bridge seismic demands in longitudinal directions with different friction interfaces are compared by nonlinear dynamic analysis on a typical LRB-supported concrete bridge. The results show the causalities of the displacements and decreases of the friction coefficient of the LRB. The breakaway coefficient of friction of the concrete surface was generally greater than that of the steel in the pre-sliding stage, while the sliding coefficient of friction of the steel interface in the post-sliding stage was greater than that of the concrete. Moreover, the proposed three-fold constitutive model is able to simulate the frictional sliding behavior of LRBs accurately. Lastly, the seismic design of small-to-medium-span bridges should take into account the breakaway-sliding friction effect of the LRBs and the preference for steel as friction pads for LRBs is recommended. Full article

There has been an increase in the use of ultrasonic arrays for the detection of defects in composite structures used in the aerospace industry. The response of a defect embedded in such a medium is influenced by the inherent anisotropy of the bounding medium and the layering of the bounding medium and hence poses challenges for the interpretation of the full matrix capture (FMC) results. Modeling techniques can be used to understand and simulate the effect of the structure and the defect on the received signals. Existing modeling techniques, such as finite element methods (FEM), finite difference time domain (FDTD), and analytical solutions, are computationally inefficient or are singularly used for structures with complex geometries. In this paper, we develop a novel model based on the Gaussian-based recursive stiffness matrix approach to model the scattering from a side-drilled hole embedded in an anisotropic layered medium. The paper provides a novel method to calculate the transmission and reflection coefficients of plane waves traveling from a layered anisotropic medium into a semi-infinite anisotropic medium by combining the transfer matrix and stiffness matrix methods. The novelty of the paper is the developed model using Gaussian beams to simulate the scattering from a Side Drilled Hole (SDH) embedded in a multilayered composite laminate, which can be used in both immersion and contact setups. We describe a method to combine the scattering from defects with the model to simulate the response of a layered structure and to simulate the full matrix capture (FMC) signals that are received from an SDH embedded in a layered medium. The model-assisted correction total focusing method (MAC-TFM) imaging is used to image both the simulated and experimental results. The proposed method has been validated for both isotropic and anisotropic media by a qualitative and quantitative comparison with experimentally determined signals. The method proposed in this paper is modular, computationally inexpensive, and is in good agreement with experimentally determined signals, and it enables us to understand the effects of various parameters on the scattering of a defect embedded in a layered anisotropic medium. Full article

The scope of additive manufacturing, particularly fused deposition modelling (FDM), can indeed be explored with the fabrication of multi-material composite laminates using this technology. Laminar composite structures made up of two distinct materials, namely acrylonitrile butadiene styrene (ABS) and carbon fiber reinforced polylactic acid (CF-PLA), were produced using the FDM process. The current study analyzes the effect of various printing parameters on the interfacial bond strength (IFBS) of the ABS/CF-PLA laminar composite by employing response surface methodology. The physical examination of the tested specimens revealed two failure modes, where failure mode 1 possessed high IFBS owing to the phenomenon of material patch transfer. Contrarily, failure mode 2 yielded low IFBS, while no patch transfer was observed. The analysis of variance (ANOVA) revealed that printing parameters were highly interactive in nature. After extensive experimentation, it was revealed that good quality of IFBS is attributed to the medium range of printing speed, high infill density, and low layer height. At the same time, a maximum IFBS of 20.5 MPa was achieved. The study presented an empirical relation between printing parameters and IFBS that can help in forecasting IFBS at any given printing parameters. Finally, the optimized printing conditions were also determined with the aim to maximize IFBS. Full article

A new, transparent, metal-free absorber, based on the use of multilayer graphene/dielectric laminates (GLs), is proposed for applications in the low-terahertz frequency range. The designed absorber has a total thickness of around 70 µm and consists of a front matching dielectric layer followed by a GL, a dielectric spacer and a back GL. The laminates are periodic structures constituted of graphene sheets separated by 50-nm-thick polyethylene terephthalate (PET) interlayers, while the matching layer and the spacer are one-quarter-wavelength thick and made of PET. The GLs are modeled as homogeneous-equivalent single layers (ESLs) characterized by their sheet resistances R_s. An innovative analytical method is proposed in order to select R_s values optimizing the electromagnetic wave absorption either in low-gigahertz or low-terahertz frequency range. The frequency spectra of the absorption, reflection and transmission coefficients are computed in the range up to 4 THz by using different values of R_s. Then, realistic R_s values of chemically doped graphene monolayers over PET substrates are considered. The designed absorbers are characterized by an absorption coefficient with a peak value of about 0.8 at the first resonant frequency of 1.1 THz, and a 1.4 THz bandwidth centered at 1.5 THz with reflection coefficient below - 10 dB. Moreover, the optical transmittance of the proposed absorbers are computed by means of the optical matrix theory and it is found to be greater than 86% in all the visible ranges. Full article

Multi-scale bedding fractures, i.e., km-scale regional bedding fractures and cm-scale lamina-induced fractures, have been the focus of unconventional oil and gas exploration and play an important role in resource exploration and drilling practice for tight oil and gas. It is challenging to conduct numerical simulations of bedding fractures due to the strong heterogeneity without a proper mechanical criterion to predict failure behaviors. This research modified the Tien–Kuo (T–K) criterion by using four critical parameters (i.e., the maximum principal stress (σ₁), minimum principal stress (σ₃), lamina angle (θ), and lamina friction coefficient (μ_lamina)). The modified criterion was compared to other bedding failure criteria to make a rational finite element simulation constrained by the four variables. This work conducted triaxial compression tests of 18 column samples with different lamina angles to verify the modified rock failure criterion, which contributes to the simulation work on the multi-scale bedding fractures in the statics module of the ANSYS workbench. The cm-scale laminated rock samples and the km-scale Yanchang Formation in the Ordos Basin were included in the multi-scale geo-models. The simulated results indicate that stress is prone to concentrate on lamina when the lamina angle is in an effective range. The low-angle lamina always induces fractures in an open state with bigger failure apertures, while the medium-angle lamina tends to induce fractures in a shear sliding trend. In addition, the regional bedding fractures of the Yanchang Formation in the Himalayan tectonic period tend to propagate under the conditions of lower maximum principal stress, higher minimum principal stress, and larger stratigraphic dip. Full article