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25 pages, 1759 KiB  
Article
A Comparative Evaluation of the Thermal Performance of Passive Facades with Variable Cavity Widths for Near-Zero Energy Buildings (nZEB): A Modeling Study
by Eugen Iavorschi, Laurențiu Dan Milici, Constantin Ungureanu and Ciprian Bejenar
Appl. Sci. 2025, 15(13), 7019; https://doi.org/10.3390/app15137019 - 22 Jun 2025
Cited by 1 | Viewed by 779
Abstract
In the current context of the transition toward climate neutrality and the pressing need to reduce energy consumption in the construction sector, nZEBs have become a central benchmark in European sustainability policies. These buildings offer multiple benefits, such as reduced operational costs, enhanced [...] Read more.
In the current context of the transition toward climate neutrality and the pressing need to reduce energy consumption in the construction sector, nZEBs have become a central benchmark in European sustainability policies. These buildings offer multiple benefits, such as reduced operational costs, enhanced thermal comfort, and improved indoor air quality. Achieving such performance requires the integration of advanced technological solutions, including passive façades with ventilated cavities. The primary objective of this study is to investigate the influence of cavity geometry on the thermal behavior of a passive façade, through numerical simulations conducted in ANSYS Fluent 17. The study focuses on comparing five distinct configurations with varying cavity widths, aiming to identify the optimal solution in terms of heat transfer efficiency. The main contribution lies in the analysis and correlation of air temperature and velocity distributions with the cavity’s geometric parameters, highlighting the impact of channel width on thermal performance. The configuration with a 12 cm wide air channel recorded the highest heat flux at the outlet, approximately 44 times greater than the façade with a 4 cm wide channel, making it the most efficient solution. The results indicate significantly higher thermal efficiency for the configuration with a larger cavity width, contrary to initial intuitive assumptions. These insights provide a valuable framework for the optimal design of passive façades in nZEB applications and highlight the need for further research, combining numerical and experimental approaches, to develop sustainable and energy-efficient building envelope solutions. Full article
(This article belongs to the Special Issue Advancements in HVAC Technologies and Zero-Emission Buildings)
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27 pages, 744 KiB  
Article
Microhooks: A Novel Framework to Streamline the Development of Microservices
by Omar Iraqi, Mohamed El Kadiri El Hassani and Anass Zouine
Computers 2025, 14(4), 139; https://doi.org/10.3390/computers14040139 - 7 Apr 2025
Viewed by 1503
Abstract
The microservices architectural style has gained widespread adoption in recent years thanks to its ability to deliver high scalability and maintainability. However, the development process for microservices-based applications can be complex and challenging. Indeed, it often requires developers to manage a large number [...] Read more.
The microservices architectural style has gained widespread adoption in recent years thanks to its ability to deliver high scalability and maintainability. However, the development process for microservices-based applications can be complex and challenging. Indeed, it often requires developers to manage a large number of distributed components with the burden of handling low-level, recurring needs, such as inter-service communication, brokering, event management, and data replication. In this article, we present Microhooks: a novel framework designed to streamline the development of microservices by allowing developers to focus on their business logic while declaratively expressing the so-called low-level needs. Based on the inversion of control and the materialized view patterns, among others, our framework automatically generates and injects the corresponding artifacts, leveraging 100% build time code introspection and instrumentation, as well as context building, for optimized runtime performance. We provide the first implementation for the Java world, supporting the most popular containers and brokers, and adhering to the standard Java/Jakarta Persistence API. From the user perspective, Microhooks exposes an intuitive, container-agnostic, broker-neutral, and ORM framework-independent API. Microhooks evaluation against state-of-the-art practices has demonstrated its effectiveness in drastically reducing code size and complexity, without incurring any considerable cost on performance. Based on such promising results, we believe that Microhooks has the potential to become an essential component of the microservices development ecosystem. Full article
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19 pages, 690 KiB  
Article
A Holistic Framework for Developing Expert Systems to Improve Energy Efficiency in Manufacturing
by Borys Ioshchikhes, Robin Zink, Oskay Ozen and Matthias Weigold
Energies 2025, 18(6), 1406; https://doi.org/10.3390/en18061406 - 12 Mar 2025
Viewed by 803
Abstract
Amid growing environmental and societal concerns about energy use, companies face increasing pressure to adopt sustainable manufacturing practices. The European Union’s guiding principles, aimed in part at achieving climate neutrality and fostering green growth, underscore the need for systematic, data-driven approaches to energy [...] Read more.
Amid growing environmental and societal concerns about energy use, companies face increasing pressure to adopt sustainable manufacturing practices. The European Union’s guiding principles, aimed in part at achieving climate neutrality and fostering green growth, underscore the need for systematic, data-driven approaches to energy efficiency. This involves the measurement, monitoring, and analysis of energy data. However, identifying efficiency potentials often relies on expert knowledge, which is becoming increasingly scarce due to skilled labor shortages. Expert systems offer a solution by consolidating and analyzing data to automatically identify energy-saving opportunities. These systems leverage stored expertise, applying it to measurement data to generate actionable insights, while their explicit knowledge representation and transparent reasoning facilitate knowledge transfer. Despite their potential, most expert systems are developed intuitively and tailored to specific applications, limiting their broader adoption. To address this, we propose a holistic framework for systematic expert system development, supported by defined personas and an expert system shell serving as a software template. The framework is demonstrated and evaluated through its application in a metalworking process chain. Full article
(This article belongs to the Section B: Energy and Environment)
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31 pages, 5016 KiB  
Article
Using Neutrosophic Cognitive Maps to Support Group Decisions About Modeling and Analyzing Smart Port Performance
by Antonios Paraskevas, Michael Madas and Yiannis Nikolaidis
Appl. Sci. 2025, 15(4), 1981; https://doi.org/10.3390/app15041981 - 13 Feb 2025
Cited by 1 | Viewed by 988
Abstract
Contemporary ports are facing a variety of challenges due to technological advancements, economic pressures, and changing policies. Key issues include the effects of globalization, rapid advancements in information and communication technologies (ICTs), and the changing nature of port services. In order to tackle [...] Read more.
Contemporary ports are facing a variety of challenges due to technological advancements, economic pressures, and changing policies. Key issues include the effects of globalization, rapid advancements in information and communication technologies (ICTs), and the changing nature of port services. In order to tackle these challenges and achieve operational excellence, adapt to the shifting of activities, and meet new business demands, smart ports have been proposed as a comprehensive solution. These challenges arise because port success is often measured by traditional metrics such as port size and performance. To accurately assess the intelligence of a port, there is a need for a systematic and scientifically sound smart port evaluation method. This paper provides an overview of the concept of a smart port and develops a multi-criteria assessment framework of port smartness based on neutrosophic cognitive maps (NCMs). The unique and valuable characteristic of NCMs lies in their ability to manage the uncertainty associated with the relationship between two concepts, indicating their effects on each other in neutral states. This structure enables the NCM to provide results with a greater degree of sensitivity than fuzzy cognitive maps (FCMs) and allows for a greater degree of freedom of intuition for an expert to express not only the potential impacts but also the uncertainty associated with those impacts. Our methodology can make decisions using incomplete, uncertain, and inconsistent data during the assessment process, providing a rigorous quantitative framework for the assessment of port “smartness”. The proposed solution has the potential to act as a valuable tool in a group decision support environment and can be used to accelerate an organization’s development, improve productivity, and reinforce efforts to achieve strategic and sustainability objectives. To achieve this, an appropriate framework for such a methodology is demonstrated through an illustrative example offering actionable insights for improving port operations. Full article
(This article belongs to the Special Issue Intelligent Logistics and Supply Chain Systems)
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15 pages, 7134 KiB  
Article
Single-Handed Gesture Recognition with RGB Camera for Drone Motion Control
by Guhnoo Yun, Hwykuen Kwak and Dong Hwan Kim
Appl. Sci. 2024, 14(22), 10230; https://doi.org/10.3390/app142210230 - 7 Nov 2024
Cited by 2 | Viewed by 2469
Abstract
Recent progress in hand gesture recognition has introduced several natural and intuitive approaches to drone control. However, effectively maneuvering drones in complex environments remains challenging. Drone movements are governed by four independent factors: roll, yaw, pitch, and throttle. Each factor includes three distinct [...] Read more.
Recent progress in hand gesture recognition has introduced several natural and intuitive approaches to drone control. However, effectively maneuvering drones in complex environments remains challenging. Drone movements are governed by four independent factors: roll, yaw, pitch, and throttle. Each factor includes three distinct behaviors—increase, decrease, and neutral—necessitating hand gesture vocabularies capable of expressing at least 81 combinations for comprehensive drone control in diverse scenarios. In this paper, we introduce a new set of hand gestures for precise drone control, leveraging an RGB camera sensor. These gestures are categorized into motion-based and posture-based types for efficient management. Then, we develop a lightweight hand gesture recognition algorithm capable of real-time operation on even edge devices, ensuring accurate and timely recognition. Subsequently, we integrate hand gesture recognition into a drone simulator to execute 81 commands for drone flight. Overall, the proposed hand gestures and recognition system offer natural control for complex drone maneuvers. Full article
(This article belongs to the Section Aerospace Science and Engineering)
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13 pages, 561 KiB  
Article
Assessing Carbon Sink Capacity in Coal Mining Areas: A Case Study from Taiyuan City, China
by Fan Chen, Yang Liu, Jinkai Guo, He Bai, Zhitao Wu, Yang Liu and Ruijin Li
Atmosphere 2024, 15(7), 765; https://doi.org/10.3390/atmos15070765 - 27 Jun 2024
Cited by 2 | Viewed by 1388
Abstract
Climate warming and air pollution are atmospheric environmental problems that have aroused broad concern worldwide. Greenhouse gas emissions are the main cause of global warming. In addition to reducing carbon emissions, increasing carbon sink capacity and improving environmental quality are essential for building [...] Read more.
Climate warming and air pollution are atmospheric environmental problems that have aroused broad concern worldwide. Greenhouse gas emissions are the main cause of global warming. In addition to reducing carbon emissions, increasing carbon sink capacity and improving environmental quality are essential for building green and low-carbon enterprises under carbon peak and carbon neutrality goals. Currently, the research on the methods and application of carbon sink capacity assessment in coal mining enterprises is limited. Given this, this study estimated the carbon absorption, carbon storage, and net ecosystem productivity of a typical coal mining area in Taiyuan City, China, and compared the characteristics and applicability of the three methods. The results showed the following: (1) The total carbon absorption (carbon sink) of the mining area in 2021 was 117.39 t, the primary source of which is forest land. (2) The total carbon storage in the mining area in 2021 was 29,561.96 t. From different land use types, the carbon storage in the mining area mainly came from forest land (27,867.73 t); from the perspective of carbon pool, soil carbon storage (21,970.96 t) had the most significant contribution to the carbon storage of mining areas. (3) The net ecosystem productivity of the mining area in 2021 was 781.97 g/(m2·a), indicating that the ecosystem of the mining area was a carbon sink. (4) The three estimation methods differed in the current case. The estimation method for carbon absorption is the simplest, and the results are the most intuitive. The estimation method for net ecosystem productivity is the most complex. The carbon sink estimation via carbon storage needs to collect two years of data. Enterprises should assess the carbon sink capacity of mining areas based on existing conditions and data. This study proposes methods for estimating carbon sink capacity in mining areas, which have positive practical significance for the low-carbon green development of coal mine enterprises. Full article
(This article belongs to the Special Issue Urban Air Pollution Control and Low-Carbon Development)
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26 pages, 1278 KiB  
Systematic Review
Assessment of Intuitive Eating and Mindful Eating among Higher Education Students: A Systematic Review
by Fabiane Rezende, Bruno M. P. M. Oliveira and Rui Poínhos
Healthcare 2024, 12(5), 572; https://doi.org/10.3390/healthcare12050572 - 29 Feb 2024
Cited by 6 | Viewed by 5641
Abstract
Background: The role of mindful eating (ME) and intuitive eating (IE) in improving eating behavior, diet quality, and health is an area of increasing interest. Objective: The objective of this review was to identify the instruments used to assess ME and IE among [...] Read more.
Background: The role of mindful eating (ME) and intuitive eating (IE) in improving eating behavior, diet quality, and health is an area of increasing interest. Objective: The objective of this review was to identify the instruments used to assess ME and IE among higher education students and outcomes related to these dimensions. Methods: This review was carried out according to the PRISMA statement, through systematic searches in PubMed, Web of Science, PsycInfo, and Scopus. The inclusion criteria selected for higher education students, levels of ME and/or IE reported, and observational and clinical studies. The exclusion criteria selected against reviews, qualitative studies, and case studies. Quality was assessed using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Results: A total of 516 initial records were identified, from which 75 were included. Cross-sectional studies were the most common research design (86.7%). Most studies were conducted with samples that were predominantly female (90.7%), White (76.0%), aged 18 to 22 years (88.4%), with BMI < 25 kg/m2 (83.0%), and in the United States (61.3%). The Intuitive Eating Scale (IES), the Mindful Eating Questionnaire (MEQ), and their different versions were the most used instruments. The outcomes most studies included were eating behavior and disorders (77.3%), anthropometric assessments (47.8%), mental health (42.0%), and body image (40.6%). Regarding the quality of studies, 34.7% of studies were assigned a positive, 1.3% a negative, and 64.0% a neutral rate. Conclusions: IES and MEQ were the most used instruments. RCT and cohort studies are scarce, and future research with a higher level of quality is needed, especially on the topics of food consumption, diet quality, and biochemical markers. Full article
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18 pages, 366 KiB  
Article
Exploring Actual and Presumed Links between Accurately Inferring Contents of Other People’s Minds and Prosocial Outcomes
by Sara D. Hodges, Murat Kezer, Judith A. Hall and Jacquie D. Vorauer
J. Intell. 2024, 12(2), 13; https://doi.org/10.3390/jintelligence12020013 - 26 Jan 2024
Cited by 2 | Viewed by 2325
Abstract
The term “empathic accuracy” has been applied to people’s ability to infer the contents of other people’s minds—that is, other people’s varying feelings and/or thoughts over the course of a social interaction. However, despite the ease of intuitively linking this skill to competence [...] Read more.
The term “empathic accuracy” has been applied to people’s ability to infer the contents of other people’s minds—that is, other people’s varying feelings and/or thoughts over the course of a social interaction. However, despite the ease of intuitively linking this skill to competence in helping professions such as counseling, the “empathic” prefix in its name may have contributed to overestimating its association with prosocial traits and behaviors. Accuracy in reading others’ thoughts and feelings, like many other skills, can be used toward prosocial—but also malevolent or morally neutral—ends. Prosocial intentions can direct attention towards other people’s thoughts and feelings, which may, in turn, increase accuracy in inferring those thoughts and feelings, but attention to others’ thoughts and feelings does not necessarily heighten prosocial intentions, let alone outcomes. Full article
27 pages, 2972 KiB  
Article
Research on the Risk-Inducing Factors of Prefabricated Building Design Change Based on Improved DEMATEL-ISM
by Ran Sun, Xiaoxiao Geng, Li Zhao, Yingchen Wang and Ruifang Guo
Buildings 2023, 13(12), 3036; https://doi.org/10.3390/buildings13123036 - 6 Dec 2023
Cited by 7 | Viewed by 2066
Abstract
Under the background of China’s progress towards the goals of “carbon peak” and “carbon neutrality”, prefabricated buildings have developed rapidly due to their advantages of energy conservation and environmental protection, low construction cost, and high efficiency. While much attention has been paid to [...] Read more.
Under the background of China’s progress towards the goals of “carbon peak” and “carbon neutrality”, prefabricated buildings have developed rapidly due to their advantages of energy conservation and environmental protection, low construction cost, and high efficiency. While much attention has been paid to prefabricated buildings, less has been studied about the risk factors that cause engineering changes. In this paper, the factors that induce the risk of design change were identified from six aspects: personnel management, resource management, organization management, information and communication, collaboration mechanism, and technical level. The improved DEMATEL-ISM model was established in a fuzzy environment, the relationship between the influencing factors was quantitatively analyzed, the hierarchy between the factors was intuitively reflected, and the driving force and dependence of each factor were clearly displayed; it was concluded that poor organizational ability, errors and omissions in design, time lag between design and construction, immature component splitting and deepening design technology, and low standardization of production components in component factories are the key factors that induce the risk of design change. Finally, management implications for the relationship between various factors were proposed. This article provides references and help for the construction industry to effectively manage the risks caused by design changes. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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28 pages, 7911 KiB  
Article
Beam Transmission (BTR) Software for Efficient Neutral Beam Injector Design and Tokamak Operation
by Eugenia Dlougach and Margarita Kichik
Software 2023, 2(4), 476-503; https://doi.org/10.3390/software2040022 - 24 Oct 2023
Cited by 4 | Viewed by 3748
Abstract
BTR code (originally—“Beam Transmission and Re-ionization”, 1995) is used for Neutral Beam Injection (NBI) design; it is also applied to the injector system of ITER. In 2008, the BTR model was extended to include the beam interaction with plasmas and direct beam losses [...] Read more.
BTR code (originally—“Beam Transmission and Re-ionization”, 1995) is used for Neutral Beam Injection (NBI) design; it is also applied to the injector system of ITER. In 2008, the BTR model was extended to include the beam interaction with plasmas and direct beam losses in tokamak. For many years, BTR has been widely used for various NBI designs for efficient heating and current drive in nuclear fusion devices for plasma scenario control and diagnostics. BTR analysis is especially important for ‘beam-driven’ fusion devices, such as fusion neutron source (FNS) tokamaks, since their operation depends on a high NBI input in non-inductive current drive and fusion yield. BTR calculates detailed power deposition maps and particle losses with an account of ionized beam fractions and background electromagnetic fields; these results are used for the overall NBI performance analysis. BTR code is open for public usage; it is fully interactive and supplied with an intuitive graphical user interface (GUI). The input configuration is flexibly adapted to any specific NBI geometry. High running speed and full control over the running options allow the user to perform multiple parametric runs on the fly. The paper describes the detailed physics of BTR, numerical methods, graphical user interface, and examples of BTR application. The code is still in evolution; basic support is available to all BTR users. Full article
(This article belongs to the Special Issue Software Analysis, Evolution, Maintenance and Visualization)
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6 pages, 2062 KiB  
Proceeding Paper
Effects of Multisensory Contexts on Tofu and Soy Sauce Evaluation and Consumption
by Haruka Hiraguchi, Erik van der Burg, Ivo V. Stuldreher, Alexander Toet, Sebastien Velut, Elizabeth H. Zandstra, Demi van Os, Maarten A. Hogervorst, Jan B. F. van Erp and Anne-Marie Brouwer
Biol. Life Sci. Forum 2023, 26(1), 36; https://doi.org/10.3390/Foods2023-15059 - 14 Oct 2023
Viewed by 1022
Abstract
We examined the effects of an informative pitch and multisensory contexts as potential factors influencing individuals’ experience of tofu with soy sauce and the amount consumed outside the lab. Two hundred and sixteen participants watched one of two pitches (promoting either vegetarian diets [...] Read more.
We examined the effects of an informative pitch and multisensory contexts as potential factors influencing individuals’ experience of tofu with soy sauce and the amount consumed outside the lab. Two hundred and sixteen participants watched one of two pitches (promoting either vegetarian diets or exercise) and were guided into one of three multisensory contexts (‘sustainable’, ‘meat’, or ‘neutral’ theme). Participants rated the aroma and appearance of soy sauce and the taste of tofu dipped in it using the intuitive ‘one touch’ EmojiGrid valence and arousal measuring tool. Our results showed that the ‘meat’ context increased arousal ratings for soy sauce and the tendency to consume more tofu relative to the other contexts. Pitch did not influence affective ratings or amounts consumed. We conclude that the multisensory context has the potential to positively affect peoples’ choices and perceptions of plant-based and sustainable food and promote its consumption. Full article
(This article belongs to the Proceedings of The 4th International Electronic Conference on Foods)
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14 pages, 821 KiB  
Article
Some Insights into the Factors Influencing Continuous Citation of Retracted Scientific Papers
by Bor Luen Tang
Publications 2023, 11(4), 47; https://doi.org/10.3390/publications11040047 - 8 Oct 2023
Viewed by 4626
Abstract
Once retracted, the citation count of a research paper might be intuitively expected to drop precipitously. Here, we assessed the post-retraction citation of life and medical sciences papers from two top-ranked, multidisciplinary journals Nature and Science, from 2010 to 2018. Post-retraction citations [...] Read more.
Once retracted, the citation count of a research paper might be intuitively expected to drop precipitously. Here, we assessed the post-retraction citation of life and medical sciences papers from two top-ranked, multidisciplinary journals Nature and Science, from 2010 to 2018. Post-retraction citations accounted for a staggering 47.7% and 40.9% of total citations (median values), respectively, of the papers included in our analysis. These numbers are comparable with those from two journals with lower impact factors, and with retracted papers from the physical sciences discipline. A more qualitative assessment of five papers from the two journals with a high percentage (>50%) of post-retraction citations, all of which are associated with misconduct, reveal different contributing reasons and factors. Retracted papers associated with highly publicized misconduct cases are more prone to being cited with the retraction status indicated, or projected negatively (such as in the context of research ethics and misconduct discussions), with the latter also indicated by cross-disciplinary citations by humanities and social sciences articles. Retracted papers that retained significant validity in their main findings/conclusions may receive a large number of neutral citations that are somewhat blind to the retraction. Retracted papers in popular subject areas with massive publication outputs, particularly secondary publications such as reviews, may also have a high background citation noise. Our findings add further insights to the nature of post-retraction citations beyond the plain notion that these are largely made through sheer ignorance or negligence by the citing authors. Full article
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31 pages, 21611 KiB  
Article
Post-Subduction Granite Magmatism and Gold-Sulfide Mineralization in the Abu Zawal (Fatira) Area, Eastern Desert, Egypt
by Refaey M. El-Wardany, Jiangang Jiao, Basem Zoheir, Mustafa Kumral, Mustafa Kaya and Amr Abdelnasser
Minerals 2023, 13(4), 489; https://doi.org/10.3390/min13040489 - 30 Mar 2023
Cited by 2 | Viewed by 5102
Abstract
Gold-sulfide mineralization in the Abu Zawal (Fatira) mine area, North Eastern Desert of Egypt, is related to porphyritic felsite dikes and elongate silicification zones in granitic rocks. These felsite dikes and the host granitic rocks exhibit major and trace element geochemical features typical [...] Read more.
Gold-sulfide mineralization in the Abu Zawal (Fatira) mine area, North Eastern Desert of Egypt, is related to porphyritic felsite dikes and elongate silicification zones in granitic rocks. These felsite dikes and the host granitic rocks exhibit major and trace element geochemical features typical of calc-alkaline and metaluminous I-type granites, likely originated in a late-orogenic setting. Their geochemical characteristics along with their fractionated LREE relative to HREE patterns imply either formation in a subduction-related environment or generation from subduction-modified source materials. Partial melting of subduction-metasomatized lower crustal rocks during extension following the lithospheric thickening may account for the production of such fertile, high Sr/Y and La/Yb magmas. In the Abu Zawal (Fatira) area, NE-trending altered felsite dikes, hydrothermal breccias, quartz enclaves, and wall-rock replacements are characterized by disseminations of chalcopyrite, pyrite, and rare gold. Alteration mineralogy, dominated by sericite, drusy quartz, kaolinite, calcite, and specular hematite, combined with the available fluid inclusion data suggests moderate to low temperature and near neutral pH conditions. The geochemical data of the altered wallrocks and mass balance calculations indicate significant mass losses in the altered rocks consistent with fluid/wallrock ratios higher than unity and near neutral pH conditions. Considering that the silica-rich host rocks, hydrothermal alteration, and sulfide-bearing hydrothermal quartz breccia in Fatira mine area were intuitively related to sulfur-saturated, oxidized felsic magmatism and associated hydrothermal systems, they are most likely linked to the post-subduction felsite porphyries (post-Hammamat felsites ~ 607 Ma), or pertaining to the late phases of the subaerial high-K calc-alkaline volcanics (Dokhan Volcanics ≤ 620 Ma). Full article
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19 pages, 386 KiB  
Article
Mathematical Analysis on Current–Voltage Relations via Classical Poisson–Nernst–Planck Systems with Nonzero Permanent Charges under Relaxed Electroneutrality Boundary Conditions
by Yiwei Wang, Lijun Zhang and Mingji Zhang
Membranes 2023, 13(2), 131; https://doi.org/10.3390/membranes13020131 - 19 Jan 2023
Cited by 2 | Viewed by 1483
Abstract
We focus on a quasi-one-dimensional Poisson–Nernst–Planck model with small permanent charges for ionic flows of two oppositely charged ion species through an ion channel. Of particular interest is to examine the dynamics of ionic flows in terms of I–V (current–voltage) relations with boundary [...] Read more.
We focus on a quasi-one-dimensional Poisson–Nernst–Planck model with small permanent charges for ionic flows of two oppositely charged ion species through an ion channel. Of particular interest is to examine the dynamics of ionic flows in terms of I–V (current–voltage) relations with boundary layers due to the relaxation of neutral conditions on boundary concentrations. This is achieved by employing the regular perturbation analysis on the solutions established through geometric singular perturbation analysis. Rich dynamics are observed, particularly, the nonlinear interplays among different physical parameters are characterized. Critical potentials are identified, which play critical roles in the study of ionic flows and can be estimated experimentally. Numerical simulations are performed to further illustrate and provide more intuitive understandings of our analytical results. Full article
(This article belongs to the Special Issue Ion Channels in Membranes)
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16 pages, 1324 KiB  
Review
Does the Measurement of Ejection Fraction Still Make Sense in the HFpEF Framework? What Recent Trials Suggest
by Alberto Palazzuoli, Michele Correale, Massimo Iacoviello and Edoardo Gronda
J. Clin. Med. 2023, 12(2), 693; https://doi.org/10.3390/jcm12020693 - 15 Jan 2023
Cited by 7 | Viewed by 7556
Abstract
Left ventricular ejection fraction (LVEF) is universally accepted as a cardiac systolic function index and it provides intuitive interpretation of cardiac performance. Over the last two decades, it has erroneously become the leading feature used by clinicians to characterize the left ventricular function [...] Read more.
Left ventricular ejection fraction (LVEF) is universally accepted as a cardiac systolic function index and it provides intuitive interpretation of cardiac performance. Over the last two decades, it has erroneously become the leading feature used by clinicians to characterize the left ventricular function in heart failure (HF). Notably, LVEF sets the basis for structural and functional HF phenotype classification in current guidelines. However, its diagnostic and prognostic role in patients with preserved or mildly reduced contractile function is less clear. This is related to several concerns due to intrinsic technical, methodological and hemodynamic limitations entailed in LVEF measurement that do not describe the chamber’s real contractile performance as expressed by pressure volume loop relationship. In patients with HF and preserved ejection fraction (HFpEF), it does not reflect the effective systolic function because it is prone to preload and afterload variability and it does not account for both longitudinal and torsional contraction. Moreover, a repetitive measurement could be assessed over time to better identify HF progression related to natural evolution of disease and to the treatment response. Current gaps may partially explain the causes of negative or neutral effects of traditional medical agents observed in HFpEF. Nevertheless, recent pooled analysis has evidenced the positive effects of new therapies across the LVEF range, suggesting a potential role irrespective of functional status. Additionally, a more detailed analysis of randomized trials suggests that patients with higher LVEF show a risk reduction strictly related to overall cardiovascular (CV) events; on the other hand, patients experiencing lower LVEF values have a decrease in HF-related events. The current paper reports the main limitations and shortcomings in LVEF assessment, with specific focus on patients affected by HFpEF, and it suggests alternative measurements better reflecting the real hemodynamic status. Future investigations may elucidate whether the development of non-invasive stroke volume and longitudinal function measurements could be extensively applied in clinical trials for better phenotyping and screening of HFpEF patients. Full article
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