Search Results (189)

Objectives: The Eight-chop technique is a mechanically based nuclear segmentation method designed to improve surgical efficiency and reduce intraocular tissue stress during phacoemulsification. Early postoperative aqueous flare serves as an objective indicator of surgical invasiveness, whereas corneal endothelial cell density (CECD) loss represents a structural measure of endothelial injury. Although both parameters are clinically important, their relationship has not been systematically investigated in the context of this newer mechanical fragmentation approach. Methods: This prospective observational study included 118 eyes from 70 non-diabetic patients undergoing uncomplicated Eight-chop phacoemulsification. Aqueous flare was measured preoperatively and at postoperative Day 1, Day 7, Week 7, and Week 19 using laser flare photometry. CECD was evaluated preoperatively and at Weeks 7 and 19. Changes over time were analyzed using paired t-tests. Linear mixed-effects models (random intercept = patient ID) were constructed to assess predictors of CECD loss and postoperative intraocular pressure (IOP) reduction. Explanatory variables included Day 1 flare, age, preoperative CECD, nucleus hardness (Emery-Little grade), cumulative dissipated energy (CDE), and irrigation fluid volume. Results: Postoperative flare increased significantly at all time points (all p < 0.001), peaking on Day 7 (16.7 ± 9.21 photon counts/ms). CECD loss was extremely small, averaging 1.38% at Week 7 and 1.46% at Week 19. In mixed-effects models, Day 1 flare was not associated with CECD loss at Week 7 (p = 0.35) or Week 19 (p = 0.85). Significant predictors of CECD loss included Emery-Little grade (p = 0.004 at Week 7; p = 0.025 at Week 19), with borderline contributions from CDE and irrigation volume. IOP decreased significantly at Weeks 7 and 19; however, Day 1 flare did not predict IOP reduction. Conclusions: Eight-chop phacoemulsification produced uniformly low postoperative inflammation and exceptionally small corneal endothelial cell loss. Early postoperative flare did not predict CECD loss, suggesting that the Eight-chop technique provides a highly standardized, low-invasiveness surgical environment. These findings suggest that the Eight-chop technique lowers ultrasound energy requirements and may help reduce corneal endothelial stress relative to standard phacoemulsification. Full article

One of the main sources of entertainment is live video streaming platforms, which allow viewers to watch video streams in real time. However, because of the increasing demand for high quality content, the vulnerability of streaming systems against cyberattacks highlights how crucial it is to implement strong security mechanisms without sacrificing performance. Therefore, the safeguard of video streams against cyberthreats such as content tampering and interception is a top priority while still maintaining robustness against network fluctuations. Two distinct scenarios are proposed to test AES-128 encryption in securing HTTP live streaming segments against content tampering and resilience to packet loss. Results show that AES-128 encryption provides confidentiality and successfully prevents meaningful manipulation of the video content, confirming its reliability as segment encryption does not significantly alter packet loss-induced playback behavior compared to unencrypted streaming under the tested conditions, Performance analysis shows that AES-128 has no significant difference in data loss for up to 4% of network packet loss compared to unencrypted segments. Full article

The hydrophobic region of semaglutide makes it prone to aggregation in aqueous solution, which leads to serious interception in microfiltration. The influences of pH and low concentrations of salts (NaCl, CH₃COONa, Na₂SO₄ and (NH₄)₂SO₄) on the particle size and zeta potential of semaglutide aggregates were studied in this work. The results showed pH could change the zeta potential on the semaglutide surface, but the impact on semaglutide dispersion was limited. When salts were introduced into aqueous solution, NaCl had a more significant dispersion effect on semaglutide than other salts. Under pH 2.5 or pH 8.0 conditions, the addition of 0.01 mol/L NaCl reduced the average particle size of semaglutide aggregates to below 70 nm. The permeability of semaglutide in microfiltration increased from 60% to 86% under optimized conditions with the PES membrane (0.22 μm), and the adsorption loss also reduced 40%. In addition, this study compared the HPLC detection precision of semaglutide samples prefiltered with different microfiltration filters. Some semaglutide was intercepted by various microfiltration filters, resulting in serious detection errors. When semaglutide was dissolved in the aqueous solution containing 0.01 mol/L NaCl with pH 2.5, the detection error was controlled within 1%. Full article

An early and accurate detection of retinal lesions is imperative to intercept the course of sight-threatening ailments, such as Diabetic Retinopathy (DR) or Age-related Macular Degeneration (AMD). Manual expert annotation of all such lesions would take a long time and would be subject to interobserver tendencies, especially in large screening projects. This work introduces an end-to-end deep learning pipeline for automated retinal lesion segmentation, tailored to datasets without available expert pixel-level reference annotations. The approach is specifically designed for our needs. A novel multi-stage automated ground truth mask generation method, based on colour space analysis, entropy filtering and morphological operations, and creating reliable pseudo-labels from raw retinal images. These pseudo-labels then serve as the training input for a U-Net architecture, a convolutional encoder–decoder architecture for biomedical image segmentation. To address the inherent class imbalance often encountered in medical imaging, we employ and thoroughly evaluate a novel hybrid loss function combining Focal Loss and Dice Loss. The proposed pipeline was rigorously evaluated on the ‘Eye Image Dataset’ from Kaggle, achieving a state-of-the-art segmentation performance with a Dice Similarity Coefficient of 0.932, Intersection over Union (IoU) of 0.865, Precision of 0.913, and Recall of 0.897. This work demonstrates the feasibility of achieving high-quality retinal lesion segmentation even in resource-constrained environments where extensive expert annotations are unavailable, thus paving the way for more accessible and scalable ophthalmological diagnostic tools. Full article

Bone metastases remain a leading cause of morbidity and mortality in patients with advanced breast, prostate, and lung cancers. A striking clinical feature of bone metastasis is the ability of disseminated tumor cells (DTCs) to persist in a dormant state for years or even decades before reawakening to drive overt disease. While the molecular and microenvironmental cues that induce and maintain dormancy have been increasingly studied, the mechanisms governing dormancy escape remain poorly defined yet are critical for preventing relapse. In this review, we synthesize emerging evidence on how the bone microenvironment orchestrates the transition of dormant tumor cells into proliferative lesions. We discuss how osteoclast-mediated bone resorption liberates growth factors such as TGF-β and IGF-1, fueling reactivation; how loss of osteoblast-mediated quiescence signals disrupts the endosteal niche; and how bone marrow adipocytes provide metabolic support through lipid transfer and adipokine secretion. We highlight the role of immune surveillance in maintaining dormancy and how immunosuppressive myeloid populations, regulatory T cells, and inflammatory triggers, such as neutrophil extracellular traps, promote escape. Additional emphasis is placed on extracellular matrix remodeling, mechanotransduction, angiogenic switching, and systemic factors, including aging, hormonal changes, and sympathetic nervous system activation. We also review epigenetic and metabolic reprogramming events within dormant cells that enable reactivation. Finally, we evaluate therapeutic strategies to sustain dormancy or prevent reawakening, including osteoclast-targeted therapies, immune-modulating approaches, and epigenetic or metabolic interventions. By integrating these insights, we identify key knowledge gaps and propose future directions to intercept dormancy escape and delay or prevent metastatic relapse in bone. Full article

This study examined the relationship between training load, mileage, and session rating of perceived exertion (s-RPE) as predictors of injury and illness in Division I women’s soccer players. Twenty-four athletes were monitored over a 13-week season including 69 athlete exposures (49 training sessions and 20 matches). Internal and external load were measured during each athlete exposure. Player injury and illness status were documented daily by medical staff and categorized as healthy, medical attention, or time-loss. Associations between athlete exposures and injury/illness status were analyzed using a mixed-effects ordinal logistic regression model with player ID as a random intercept. A total of 1560 athlete observations were included. Higher daily mileage was associated with increased odds of injury or illness (OR = 1.67, 95% CI: 1.19–2.34). Training load was associated with reduced odds of injury or illness, with each unit increase lowering the odds by 42% (OR = 0.58, 95% CI: 0.41–0.83). Session-RPE was not significantly associated with injury or illness (OR = 0.96, 95% CI: 0.65–1.42). These findings indicate that accumulated mileage elevates injury and illness risk, while structured increases in training load enhance athlete resilience, and reduce injury and illness risk. Monitoring both internal and external workload provides performance staff with a practical approach to optimize training stress, augment recovery, and prepare athletes for the demands of competition in women’s soccer. Full article

Rockfalls represent a widespread natural hazard that threatens infrastructures and settlements in mountainous and coastal areas. In Baunei (Sardinia, Italy), steep carbonate cliffs above the SS125 road frequently generate block detachments that endanger traffic and nearby urban areas. The present work adopts a quantitative risk assessment framework, consistent with the Swiss PLANAT guidelines, to evaluate the protective effectiveness of direct-protection forests in combination with engineered barriers. The framework integrates the key components of hazard, exposure, and vulnerability to quantify direct-impact risk and associated economic loss. Using Rockyfor3D simulations, three scenarios were analysed: bare slope, forest only, and forest plus protective works. The results demonstrate that vegetation markedly reduces both runout distance and kinetic energy of falling blocks, halving the direct-impact risk compared to bare-slope conditions. The addition of barriers further decreases residual exposure, with most trajectories intercepted and remaining impacts limited to low-energy classes. Monetised risk estimates confirm an 84% reduction with forest cover alone and near-complete mitigation when complemented by fences, except in short discontinuous segments. The proposed approach offers a replicable and cost-effective tool for rockfall risk management and sustainable protection forest planning in Mediterranean settings. Full article

In Mediterranean semi-arid regions, rainfed olive groves are increasingly being abandoned due to drought, low profitability, and rural depopulation. The long-term impact of abandonment on soil conditions is debated, as it may promote vegetation recovery or lead to degradation. In contrast, some farmers are adopting low-disturbance management practices that allow spontaneous vegetation to establish. These contrasting scenarios offer valuable opportunities for comparison. This study aims to develop a framework to assess the impact of different management regimes on soil health and to investigate (1) the impact of spontaneous vegetation cover (SVC) and tillage regimes on soil organic carbon (SOC), and (2) the long-term ecological dynamics of abandoned groves, through a combination of field surveys, remote sensing, and object detection. SOC was assessed using both ground-based and remote sensing-derived indicators. Vegetation cover was quantified via a grid point intercept method. Field data were integrated with a land-use monitoring framework that includes abandonment assessment through historical orthophotos and a deep learning model (YOLOv12) to detect active and abandoned olive groves. Results show that abandoned zones are richer in SOC than active ones. In particular, the active groves with SVC exhibit a mean SOC of 1%, which is higher than that of tilled groves, where SOC is 0.45%, with no apparent moisture loss. Abandoned groves can be reliably identified from aerial imagery, achieving a recall of 0.833 for abandoned patches. Our results demonstrate the potential of YOLOv12 as an innovative and accessible tool for detecting zones undergoing ecological regeneration or degradation. The study underscores the ecological and agronomic potential of spontaneous vegetation in olive agroecosystems. Full article

The exponential growth of e-commerce and advancements in financial technology have escalated credit card fraud into a major threat, resulting in billions of dollars in global losses annually. This necessitates the development of sophisticated fraud detection systems capable of real-time anomaly interception to safeguard financial activities. While federated learning frameworks have been employed to address data privacy concerns in financial applications, existing approaches often fail to account for the heterogeneity in data distributions across different institutions, such as banks, which hinders collaborative model training. In response, this paper introduces the FED-SPFD model, an innovative federated learning framework designed to detect credit card fraud amidst multi-party heterogeneous data. The model employs a share–private segmentation approach to distinguish shared from private data attributes, facilitating unified feature representation learning. It aligns disparate shared features through local sufficient statistics, thus preventing privacy breaches without directly sharing sample data. Additionally, the integration of a “private autoencoder + standard Gaussian alignment” mechanism stabilizes the training process by ensuring consistent private feature distributions. The efficacy of the FED-SPFD model is demonstrated using a real-world dataset from Kaggle, showcasing significant improvements in recall rate compared to state-of-the-art methodologies. Comprehensive evaluation through ablation studies further validates the framework’s robust contributions to accurate and privacy-preserving fraud detection. Practically, this work offers policymakers a compliant cross-institutional risk collaboration paradigm and provides financial institutions with a privacy-protective solution to enhance fraud detection without data sharing violations. Full article

To address the challenge of low modulation recognition accuracy for Low Probability of Intercept (LPI) radar waveforms under low Signal-to-Noise Ratio (SNR) conditions—a critical limitation in current radar signal processing research—this study proposes a novel recognition framework anchored in an improved EfficientNet model. First, to generate time–frequency images, the radar signals are initially subjected to time–frequency analysis using the Choi–Williams Distribution (CWD). Second, the Mobile Inverted Bottle-neck Convolution (MBConv) structure incorporates the Simple Attention Module (SimAM) to improve the network’s capacity to extract features from time–frequency images. Specifically, the original serial mechanism within the MBConv structure is replaced with a parallel convolution and attention approach, further optimizing feature extraction efficiency. Third, the network’s loss function is upgraded to Focal Loss. This modification aims to mitigate the issue of low recognition rates for specific radar signal types during training: by dynamically adjusting the loss weights of hard-to-recognize samples, it effectively improves the classification accuracy of challenging categories. Simulation experiments were conducted on 13 distinct types of LPI radar signals. The results demonstrate that the improved model validates the effectiveness of the proposed approach for LPI waveform modulation recognition, achieving an overall recognition accuracy of 96.48% on the test set. Full article

A permeable reactive barrier (PRB) containing zero-valent iron (ZVI) is an in situ groundwater remediation technology that passively intercepts and treats contaminated groundwater plumes. Over time, secondary mineral precipitation within the PRB diminishes porosity and hydraulic conductivity, altering flow paths, residence times, and sometimes causing bypass of the reactive zone. This study utilizes the THMC software to simulate porosity reduction in a PRB, capturing the coupled effects of fluid flow and geochemical interactions. The simulation results indicate that porosity loss is most significant at the PRB entrance and stabilizes beyond 0.2 m. Porosity reduction is primarily caused by aragonite, siderite, and ferrous hydroxide precipitating in pore spaces. The model further elucidates the influence of groundwater chemistry, demonstrating that variations in bicarbonate concentrations significantly impact mineral precipitation processes, thereby leading to porosity reduction. Furthermore, the study highlights reaction kinetics, with anaerobic iron corrosion rates being critical in controlling porosity reduction via mineral precipitation. THMC software effectively simulates porosity reduction in PRBs, identifies key factors driving clogging, and informs design optimization for long-term remediation. Full article

Diaporthe eres is a harmful pathogen affecting Hongyang kiwifruit (Actinidia chinensis) after harvest, yet the antioxidant defense strategies are not well understood. This research thoroughly examines the dynamics of the antioxidant response during the infection process. Significant findings indicate an initial 3-day latent period (0–3 dpi) that allowed for pathogen establishment, followed by irreversible tissue breakdown characterized by water-soaked lesions at 4 dpi. The study identified a biphasic activation pattern of superoxide dismutase (SOD) with dual activity peaks (1 dpi and 4 dpi), orchestrated by mitochondrial hub gene CEY00_Acc02790 that coordinates peroxidase (POD) networks, while peroxidase (POD) activity exhibited a synchronized but temporary increase, peaking at 4 dpi. Further bioinformatic analysis revealed the possible functional specialization of POD isoforms: α-helix-rich extracellular variants drove cell wall reinforcement through lignification, while random coil-dominant intracellular variants formed to mitigate cytoplasmic reactive oxygen species (ROS) damage, establishing dual physicochemical barriers. Malondialdehyde (MDA) levels rose significantly by 3 dpi, indicating permanent membrane damage. Collectively, these findings elucidate the mechanistic foundation of the Actinidia–Diaporthe pathosystem, identifying the bimodal SOD response and POD specialization as prime targets for developing resistant cultivars and precision postharvest interventions, ultimately reducing losses through biochemical interception of pathogenesis. Full article

Vertical containment barriers—critical for intercepting contaminant transport in subsurface environments—demand materials that balance low permeability with adequate strength, particularly in stress-sensitive mountainous terrain. Plastic concrete, as a key barrier material, provides essential properties, including exceptional stress relaxation, to suppress fracture development under compressive loads, coupled with effective seepage control. This study examines its strength performance through experiments on varied mixing techniques (dry, wet, and 24 h hydration), unconfined compression under uncontaminated conditions (water–binder ratios: 1.3–2.1, bentonite content: 20–30%, ages: 14–90 days), barium ion immersion (1–5 g/L, pH 7–11), and dry–wet cycling (10 cycles). Key findings demonstrate that (1) the strength of samples prepared by dry mixing and wet mixing is lower than that of samples mixed for 24 h, and all specimens met the target design strength following 28 days of curing; (2) under pollution-free conditions, strength decreases with higher water–binder ratios and bentonite content, showing a linear relationship. Strength increases exponentially with age; (3) in the presence of Ba²⁺, strength gradually decreases as Ba²⁺ concentration and pH increase, particularly notably at 3 g/L Ba²⁺ and pH 11. Strength increases with age, following a power relationship; (4) under dry–wet cycles, ion concentration has minimal impact on sample quality and surface state but significantly affects strength, with higher ion concentrations leading to greater strength loss and susceptibility to cycles; (5) during solution immersion, higher ion concentrations and pHs result in greater strength loss and worse erosion resistance. Full article

Low plant stands at early crop establishment contribute to yield reduction in legumes. Gap-filling has been suggested as a mechanism to mitigate these losses. There is, however, limited understanding of a yield-compensation mechanism in the cowpea. This study aimed to investigate the mechanism of yield-compensation in some accessions of cowpeas at Minjibir and Shika in Northern Nigeria. The experiment was laid out in a split plot fitted into a randomized complete block design in three replicates. The main plot consisted of four plant densities (33,333; 66,666; 99,999; 133,333 plants ha⁻¹) while the subplots consisted of six cowpea accessions (IT89KD-288, IT93K-452-1, IT99K-537-1-1, IT98K-205-8, IT08K-150-27, and DANILA). Results showed that plant density and environment affected grain yield. Total grain yield increased with increasing plant density and was higher at Minjibir than at Shika. The highest total grain yield of 1793.3 kg ha⁻¹ was observed in the accession DANILA at 99,999 plants ha⁻¹, while the lowest (1100 kg ha⁻¹) was observed in the accession IT98K-205-8 at 33,333 plants ha⁻¹. Leaf area index, stand count at harvest, and intercepted photosynthetically active radiation were positively correlated with total grain yield at both locations, suggesting that these traits could be considered for cowpea improvement. Cowpea growers and breeders could consider the erect (IT93K-452-1 and IT98K-205-8) and semi-erect accessions (IT99K-573-1-1 and IT08K-150-27) for cultivation at 133,333 plants ha⁻¹. Prostrate accessions (IT89KD-288 and DANILA) could be planted at 99,999 plants ha⁻¹ at Minjibir. The accessions IT93K-452-1-1, IT98-205-8, IT99K-573-1-1, and IT08K-150-27 could be considered for cultivation at Shika irrespective of plant density. Full article

With the rapid advances of global climate change and urbanization, urban flooding is causing greater losses. Existing urban flood control and drainage engineering design standards are often applied to single projects. This paper proposes a set of urban flood model-driven optimization of flood control and drainage engineering solutions. Applied to Shenzhen’s Shawan interception project, the preferred option demonstrates significant improvements, such as the following: a 25% reduction ratio of the maximum designed water depth at key points of the Shawan River main stream, a 0.26% reduction in the maximum submerged area of the urban surface, a 3.27% reduction in the full pipe rate of drainage pipe, and a 10.81% reduction in the overflow rate of inspection wells. The comprehensive flood control and drainage benefits are the best, and they achieve the solution of problems within the basin. Aiming at the shortage of comprehensive consideration of project scale, combination mode, and control scheme in urban flood control planning and design, this simulation scheme proposes a set of detailed design technologies of urban flood control engineering based on a flood numerical model. The analysis results show that the ideas proposed in this paper can provide a reference for the design of urban flood control and drainage engineering. Full article