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20 pages, 529 KB  
Article
Fintech Firms’ Valuations: A Cross-Market Analysis in Asia
by Neha Parashar, Rahul Sharma, Pranav Saraswat, Apoorva Joshi and Sumit Banerjee
J. Risk Financial Manag. 2026, 19(1), 74; https://doi.org/10.3390/jrfm19010074 (registering DOI) - 17 Jan 2026
Abstract
This study investigates the valuation dynamics of 30 publicly listed fintech firms across six Asian economies from January 2021 to December 2025. It examines how intrinsic firm-level scale (market capitalization) and extrinsic macroeconomic conditions (GDP growth) jointly influence fintech valuation ratios, as reflected [...] Read more.
This study investigates the valuation dynamics of 30 publicly listed fintech firms across six Asian economies from January 2021 to December 2025. It examines how intrinsic firm-level scale (market capitalization) and extrinsic macroeconomic conditions (GDP growth) jointly influence fintech valuation ratios, as reflected in price-to-earnings (P/E), price-to-book (P/B), and price-to-sales (P/S) measures. It also identifies significant structural heterogeneity and distributional asymmetries in valuation outcomes by implementing a multi-method empirical strategy that includes a Panel Autoregressive Distributed Lag (ARDL) framework, two-way fixed-effects models with interaction terms, and quantile regression. The findings reveal a robust, positive long-run relationship between market capitalization and valuation multiples across all ratios, confirming that firm-level scale as reflected in market capitalization is the primary driver of market value. Critically, the analysis identifies a dual-regime landscape in the Asian fintech sector: developed markets (South Korea, Japan, and Singapore) are fundamentally firm-scale driven, where intrinsic scale is the superior predictor of valuation. In contrast, developing markets (China, India, and Indonesia) are primarily macro-growth driven, exhibiting high sensitivity to GDP growth as a macroeconomic indicator of market expansion. The quantile regression results demonstrate a winner-takes-all effect, where the impact of scale on valuation is significantly more pronounced for highly valued firms in the 75th percentile. These results challenge the efficacy of universal valuation models and provide a context-dependent navigational framework for investors, analysts, and policymakers to distinguish between structural scale and cyclical growth in the rapidly evolving Asian fintech ecosystem. Full article
(This article belongs to the Special Issue The Role of Digitization in Corporate Finance)
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45 pages, 12265 KB  
Article
Cross-Modal Extended Reality Learning in Preschool Education: Design and Evaluation from Teacher and Student Perspectives
by Klimentini Liatou and Athanasios Tsipis
Digital 2026, 6(1), 2; https://doi.org/10.3390/digital6010002 - 26 Dec 2025
Viewed by 454
Abstract
Cross-modal and immersive technologies offer new opportunities for experiential learning in early childhood, yet few studies examine integrated systems that combine multimedia, mini-games, 3D exploration, virtual reality (VR), and augmented reality (AR) within a unified environment. This article presents the design and implementation [...] Read more.
Cross-modal and immersive technologies offer new opportunities for experiential learning in early childhood, yet few studies examine integrated systems that combine multimedia, mini-games, 3D exploration, virtual reality (VR), and augmented reality (AR) within a unified environment. This article presents the design and implementation of the Solar System Experience (SSE), a cross-modal extended reality (XR) learning suite developed for preschool education and deployable on low-cost hardware. A dual-perspective evaluation captured both preschool teachers’ adoption intentions and preschool learners’ experiential responses. Fifty-four teachers completed an adapted Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB) questionnaire, while seventy-two students participated in structured sessions with all SSE components and responded to a 32-item experiential questionnaire. Results show that teachers held positive perceptions of cross-modal XR learning, with Subjective Norm emerging as the strongest predictor of Behavioral Intention. Students reported uniformly high engagement, with AR and the interactive eBook receiving the highest ratings and VR perceived as highly engaging yet accompanied by usability challenges. The findings demonstrate how cross-modal design can support experiential learning in preschool contexts and highlight technological, organizational, and pedagogical factors influencing educator adoption and children’s in situ experience. Implications for designing accessible XR systems for early childhood and directions for future research are discussed. Full article
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22 pages, 690 KB  
Review
Patterns of Elder Caregiving Among Nigerians: An Integrative Review
by Chibuzo Stephanie Okigbo, Shannon Freeman, Dawn Hemingway, Jacqueline Holler and Glen Schmidt
Int. J. Environ. Res. Public Health 2026, 23(1), 2; https://doi.org/10.3390/ijerph23010002 - 19 Dec 2025
Viewed by 373
Abstract
This integrative review on patterns of elder caregiving in Nigeria synthesizes evolving dynamics and determinants of caregiving practices amid demographic and household change. The objective of this review was to identify prevalent patterns of elder caregiving, explore the roles and responsibilities of caregivers, [...] Read more.
This integrative review on patterns of elder caregiving in Nigeria synthesizes evolving dynamics and determinants of caregiving practices amid demographic and household change. The objective of this review was to identify prevalent patterns of elder caregiving, explore the roles and responsibilities of caregivers, and examine the challenges and support needs within the Nigerian context. Academic Search Complete, CINAHL, PubMed, PsycINFO, and Medline were searched in November 2024. Inclusion criteria were peer-reviewed journal articles published in English focusing on elder caregiving among Nigerians; non-peer-reviewed sources (e.g., dissertations, conference papers, and books) were excluded. Data extraction was performed using a structured matrix, and findings were synthesized thematically. Risk of bias was appraised using SANRA (for narrative reviews) and MMAT (for empirical studies). Twenty studies published between 1991 and December 2022 were included. Analyses were guided by an intersectional conceptual framework spanning five domains: cultural, familial, economic, psychosocial, and policy. The interconnected dimensions illustrate how cultural expectations shape family caregiving roles, which in turn influence economic strain, emotional well-being, and access to institutional support. By emphasizing the interaction among gender, class, and social location within these domains, the framework demonstrates how caregiving operates as a multidimensional and relational process. Thematic synthesis identified six overarching themes: cultural influences, gender differences, family dynamics, economic factors, challenges faced by Nigerian caregivers, and government policies and support. Limitations include reliance on single-reviewer screening and extraction, exclusion of unpublished and non-peer-reviewed sources, restriction to English-language studies, and a focus on the Nigerian context, which may limit generalizability. Findings underscore that elder caregiving in Nigeria is multifaceted and shaped by intersecting gendered, cultural, and economic forces. Policy and practice should prioritize caregiver supports, accessible geriatric services, and gender-sensitive interventions, while future research applies the framework to address gaps in transnational and multilingual evidence. Full article
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19 pages, 1428 KB  
Systematic Review
Service Design for Repair Practices in the Circular Economy: A Systematic Review Approach
by Viktoria Apostolova, Luca Simeone and Linda Nhu Laursen
World 2025, 6(4), 154; https://doi.org/10.3390/world6040154 - 13 Nov 2025
Viewed by 1486
Abstract
Within the circular economy, repair is increasingly recognised as a crucial yet underexplored strategy that extends product lifespans and reduces waste. Service design offers approaches to support this transition by addressing technical, social, and systemic dimensions. This review aimed to synthesise how service [...] Read more.
Within the circular economy, repair is increasingly recognised as a crucial yet underexplored strategy that extends product lifespans and reduces waste. Service design offers approaches to support this transition by addressing technical, social, and systemic dimensions. This review aimed to synthesise how service design contributes to repair practices and identify research gaps. Following PRISMA 2020 guidelines, we systematically searched Scopus and Web of Science, applied inclusion criteria focusing on service design and repair within the circular economy, and conducted multi-step screening and snowballing. From 132 initial records, 73 studies were included (journal articles, conference papers, book chapters). Thematic synthesis identified three areas: micro-level interactions between producers, products, and users (e.g., motivations, trust, communication); meso-level tools, frameworks, and platforms enhancing accessibility and efficiency; and macro-level societal transformation through regulations, standards, and communities. Results highlight service design’s potential to foster systemic change by integrating environmental, social, and economic aspects, while also revealing notable research gaps related to the limited engagement of repairers, policymakers, and cross-level collaboration. Compared to previous studies, this review contributes a novel integrated framework linking micro-, meso-, and macro-level dimensions of repair within the circular economy, offering both conceptual insights and actionable directions for practitioners and policymakers. The study is limited by language constraints and the lack of a formal bias evaluation. All reviewed materials are publicly accessible on OSF. This research was conducted without external financial support. Full article
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19 pages, 305 KB  
Article
Empowering Voices: Implementing Ethical Practices for Young Children’s Assent in Digital Research
by Amanda M. Mirabella, Ilene R. Berson and Michael J. Berson
Educ. Sci. 2025, 15(5), 571; https://doi.org/10.3390/educsci15050571 - 3 May 2025
Cited by 2 | Viewed by 3185
Abstract
This article examines how young children express informed assent in research settings that incorporate digital tools, participatory methods, and play-based approaches. Drawing on data from three studies involving kindergarten and first-grade children (ages 5 to 7) in the southeastern United States, this cross-case [...] Read more.
This article examines how young children express informed assent in research settings that incorporate digital tools, participatory methods, and play-based approaches. Drawing on data from three studies involving kindergarten and first-grade children (ages 5 to 7) in the southeastern United States, this cross-case analysis explores how children navigated their participation using multimodal and relational strategies. Conceptual play theory, social semiotics, and participatory research frameworks guided the analysis, emphasizing assent as an evolving, co-constructed process rather than a singular verbal agreement. Through video recordings, field notes, and action-oriented transcripts, we investigated how children expressed comfort, curiosity, and agency across diverse contexts—including virtual reality storytelling, video-cued reflection, and interactive eBooks. Findings illustrate that assent was negotiated through gesture, movement, silence, humor, and peer interaction, often extending beyond adult-defined research routines. Children reinterpreted their roles, shaped the pace of sessions, and co-constructed meaning through play and dialogue. This retrospective synthesis of three previously conducted studies offers practical and ethical insights for researchers working with young children, including the importance of ongoing assent checkpoints, developmentally appropriate explanations, and flexible research environments. We argue that ethical research with children must prioritize multimodal communication, child-led pacing, and relational trust to support authentic and meaningful participation. By reframing assent as a dynamic and multimodal process, this research contributes to emerging conversations about ethical responsiveness, agency, and inclusive practices in early childhood research. Full article
11 pages, 961 KB  
Review
The Ural Owl as a Keystone Species in Interspecific Interactions Among Avian Predators—A Review
by Łukasz Kajtoch
Diversity 2025, 17(2), 109; https://doi.org/10.3390/d17020109 - 1 Feb 2025
Cited by 1 | Viewed by 2411
Abstract
Ural owls are one of the largest owls in Europe, exhibiting known aggressive behaviour toward other raptors. They are known to interact with nearly all sympatric owls and many diurnal raptors. To summarise these interactions, a literature search was undertaken in the Web [...] Read more.
Ural owls are one of the largest owls in Europe, exhibiting known aggressive behaviour toward other raptors. They are known to interact with nearly all sympatric owls and many diurnal raptors. To summarise these interactions, a literature search was undertaken in the Web of Sciences and Scopus databases using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology as well principal books on owl biology. The search revealed 22 relevant publications that (along with the book data) described the Ural owl’s relations with seven owls and six diurnal raptor species. The Ural owl is subordinate only to the largest predators like golden eagles and eagles, although only its chicks are known to be killed. Contrary to that, the Ural owls shape the distribution of numerous other species, mostly by strong competition (e.g., forcing tawny owls to breed in suboptimal habitats) or by predation (killing smaller owls and diurnal raptors). Their occurrence could be also protective for some species like boreal owls thanks to the removal of intermediate predators. The relations of Ural owls with goshawks are interesting, which seem to live in some balance—temporal avoidance of activity with frequent co-occurrence. Thanks to their association with old-growth forests and their impact on other predators in their territories, Ural owls act as keystone species in mountainous and boreal forests in Europe. Considering this ecosystem service, Ural owls should be effectively protected e.g., by designing forest-management-free zones around their nesting sites. Full article
(This article belongs to the Special Issue Birds in Temperate and Tropical Forests—2nd Edition)
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17 pages, 1236 KB  
Article
Free Sampling, Bundling, and Digital Formatting: Exploring Strategy Effects of Digital Goods Retailers
by Li Chen
J. Theor. Appl. Electron. Commer. Res. 2025, 20(1), 11; https://doi.org/10.3390/jtaer20010011 - 13 Jan 2025
Cited by 1 | Viewed by 3665
Abstract
Retailers of digital goods such as e-books, online newspapers, and mobile applications often use strategies in multiple aspects. Meanwhile, they need to consider the interrelation between their strategies. Nevertheless, little rigorous research has been conducted on the strategy effects of retailers. Our paper [...] Read more.
Retailers of digital goods such as e-books, online newspapers, and mobile applications often use strategies in multiple aspects. Meanwhile, they need to consider the interrelation between their strategies. Nevertheless, little rigorous research has been conducted on the strategy effects of retailers. Our paper makes an exploratory effort by investigating retailers’ bundling and multi-formatting strategies on their free sample size decisions. Drawing from the prior literature, we develop a set of hypotheses related to the interplay of strategies. We collected data about 316 e-books from a popular e-commerce platform. Based on this unique dataset, we conducted a set of regression analyses to test the interactions of retailers’ strategies. Our results show that retailers would like to offer smaller free samples for e-books with which retailers offer bundling options and audiobook formats with the same content. In addition, for the bundle design features, we find that the bundle size has a significant impact on the free sample size, but the recommended bundle has not exerted such impact. Overall, our research contributes new knowledge and presents practical insights for retailers to better manage their strategy mix. Full article
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24 pages, 3816 KB  
Article
Sequence Analysis-Enhanced AI: Transforming Interactive E-Book Data into Educational Insights for Teachers
by Yaroslav Opanasenko, Emanuele Bardone, Margus Pedaste and Leo Aleksander Siiman
Educ. Sci. 2025, 15(1), 28; https://doi.org/10.3390/educsci15010028 - 31 Dec 2024
Cited by 1 | Viewed by 3368
Abstract
This study explores the potential of large language models as interfaces for conducting sequence analysis on log data from interactive E-Books. As studies show, qualitative methods are not sufficient to comprehensively study the process of interaction with interactive E-Books. The quantitative method of [...] Read more.
This study explores the potential of large language models as interfaces for conducting sequence analysis on log data from interactive E-Books. As studies show, qualitative methods are not sufficient to comprehensively study the process of interaction with interactive E-Books. The quantitative method of educational data mining (EDM) has been considered as one of the most promising approaches for studying learner interactions with E-Books. Recently, sequence analysis showed potential in identifying typical patterns of interaction from log data collected from the Estonian Interactive E-Book Platform Opiq, allowing one to see the types of sessions from students in different grades, clusters of students based on the amount of the content they studied, and the interaction type they preferred. The main goal of the present study is to understand how teachers can utilize insights from CustomGPT to enhance their understanding of students’ interaction strategies with digital learning environments (DLEs) such as Opiq, and what the potential areas for further development of such tools are. We specified the process for developing a chatbot for transferring teachers’ queries into sequence analysis results and gathered feedback from teachers, allowing us both to estimate current design solutions to make sequence analysis results available and to find potential vectors of its development. Participants provided explicit feedback on CustomGPT, appreciating its potential for group and individual analysis, while suggesting improvements in visualization clarity, legend design, descriptive explanations, and personalized tips to better meet their needs. Potential areas of development, such as integrating personalized learning statistics, enhancing visualizations and reports for individual progress and mitigating AI hallucinations by expanding training data, are described. Full article
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9 pages, 1313 KB  
Article
The Effectiveness of Applying Artificial Intelligence in Sick Children’s Communication
by Hsin-Shu Huang and Bih-O Lee
Bioengineering 2024, 11(11), 1097; https://doi.org/10.3390/bioengineering11111097 - 31 Oct 2024
Cited by 1 | Viewed by 2197
Abstract
Pediatric nursing students are required to be taught how to overcome their own psychological stress during their internship in order to understand sick children’s emotional reactions, as well as to be able to interact and communicate with such children. This quasi-experimental study proves [...] Read more.
Pediatric nursing students are required to be taught how to overcome their own psychological stress during their internship in order to understand sick children’s emotional reactions, as well as to be able to interact and communicate with such children. This quasi-experimental study proves that the application of AI image health education e-books by the nursing teacher is more effective than traditional paper handout teaching materials in improving nursing students’ self-efficacy when using therapeutic games to deal with and reduce sick children’s fears of medical examinations and treatments (p < 0.05). AI-driven tools can enable the development of personalized e-learning materials that target specific areas for cognitive improvement. This targeted approach can enhance knowledge retention and skill development, resulting in better-prepared healthcare professionals. Full article
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16 pages, 267 KB  
Article
Teacher’s Use of English and Spanish Interactive Strategies during Wordless Shared Book Reading: Relations to Emergent Bilingual Children’s Responses
by Natalia M. Rojas, Gigliana Melzi and Adina Schick
Educ. Sci. 2024, 14(10), 1096; https://doi.org/10.3390/educsci14101096 - 8 Oct 2024
Viewed by 1947
Abstract
Little attention has been paid to describing the ways early childhood education (ECE) teachers implement interactive strategies and the use of Spanish and English, in real time, to support Spanish–English emergent bilingual children’s contributions to shared book reading interactions. Video recordings from 19 [...] Read more.
Little attention has been paid to describing the ways early childhood education (ECE) teachers implement interactive strategies and the use of Spanish and English, in real time, to support Spanish–English emergent bilingual children’s contributions to shared book reading interactions. Video recordings from 19 ECE classrooms during shared book reading were used to conduct sequential analysis to examine the different types of interactive strategies (e.g., questions, extensions) implemented by bilingual ECE teachers and emergent bilinguals’ responses to these strategies. This study found that teachers’ interactive strategies may reflect a degree of reciprocity, with teachers and children sensitively attuned to one another’s contributions in real time. Teachers’ questions in English and Spanish were related to emergent bilinguals’ responses across a wide range of language complexity. Similarly, teachers and emergent bilinguals tended to respond to one another in the language of the prior utterance, suggesting teachers and emergent bilinguals are attuned to the contributions of one another. By examining teacher–child dynamics, this study produced results that can address issues that may have direct, translatable implications for ECE practice and intervention efforts. Full article
19 pages, 5022 KB  
Article
Authentication Framework for Augmented Reality with Data-Hiding Technique
by Chia-Chen Lin, Aristophane Nshimiyimana, Morteza SaberiKamarposhti and Ersin Elbasi
Symmetry 2024, 16(10), 1253; https://doi.org/10.3390/sym16101253 - 24 Sep 2024
Cited by 2 | Viewed by 1653
Abstract
Currently, most existing research on the security of augmented reality (AR) primarily focuses on user-to-user or user-to-infrastructure authentication, aiming to establish secure communication and prevent potential attacks, such as man-in-the-middle attacks, among others. AR techniques enable users to interact with virtual information and [...] Read more.
Currently, most existing research on the security of augmented reality (AR) primarily focuses on user-to-user or user-to-infrastructure authentication, aiming to establish secure communication and prevent potential attacks, such as man-in-the-middle attacks, among others. AR techniques enable users to interact with virtual information and objects within the real environment. However, creating virtual objects can be time-consuming, and unfortunately, malicious individuals may unlawfully copy these objects and integrate them into their own AR scenarios. It is essential to authenticate whether AR objects and the associated content they interact with are legitimately integrated. This paper proposes a novel method for authenticating AR-delivered content using data-hiding techniques with the symmetric property. The proposed method utilizes data hiding to embed data within the content that AR objects interact with, enabling the identification of illegal and tampered AR objects. A scenario involving an AR e-book is defined, and two data-hiding methods are applied to this scenario. The experimental results demonstrate that both data-hiding methods effectively identify the tampered image page of an AR e-book under different tone versions, new trigger image(s) added, or new image(s) replacement. Full article
(This article belongs to the Special Issue Symmetry and Asymmetry in Information Security and Network Security)
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27 pages, 897 KB  
Article
Causal Relations and Cohesive Strategies in the Narratives of Heritage Speakers of Russian in Their Two Languages
by Judy R. Kupersmitt, Sveta Fichman and Sharon Armon-Lotem
Languages 2024, 9(7), 248; https://doi.org/10.3390/languages9070248 - 15 Jul 2024
Cited by 1 | Viewed by 1796
Abstract
Causal relations allow a very detailed insight into the narrative skills of children from various backgrounds; however, their contribution has not been sufficiently studied in bilingual populations. The present study examines the expression of causal relations and the linguistic forms used to encode [...] Read more.
Causal relations allow a very detailed insight into the narrative skills of children from various backgrounds; however, their contribution has not been sufficiently studied in bilingual populations. The present study examines the expression of causal relations and the linguistic forms used to encode them in narratives of bilingual children speaking Russian as the Heritage Language (HL) and Hebrew as the Societal Language (SL). Narratives were collected from 21 typically developing Russian–Hebrew bilingual children using the Frog story picture book and were coded for frequency and type of episodic components, and for causal relations focusing on enabling and motivational relations. Results showed that the number of episodic components was higher in Hebrew than in Russian. An in-depth analysis showed that more components were mentioned in the first five episodes, particularly at the onset of the story. Causal relations were similar in both languages but were differently distributed across the languages—more enabling relations in Russian stories and more motivational relations in Hebrew stories. Production of episodic components and causal relations was affected by language proficiency but not by age of onset of bilingualism (AoB). In terms of language forms, lexical chains (e.g., search~find) were the most frequent means for inferring relations. Syntactic and referential cohesion were used in dedicated episodes to convey relations in both languages. Finally, a higher number of significant correlations between narrative productivity measures, episodic components, and causal relations were found in SL/Hebrew than in HL/Russian. The study results underscore the need to understand how language-specific abilities interact with knowledge of narrative discourse construction. Full article
(This article belongs to the Special Issue Heritage Russian Bilingualism across the Lifespan)
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14 pages, 948 KB  
Article
Using Cooking Schools to Improve the Pleasure of Food and Cooking in Patients Experiencing Smell Loss
by Alexander Wieck Fjaeldstad
Foods 2024, 13(12), 1821; https://doi.org/10.3390/foods13121821 - 10 Jun 2024
Cited by 4 | Viewed by 2448
Abstract
Smell loss affects around 15–20% of the population, with a major effect on the quality of life. The most common complaint is the impairment of the eating experience, with around 90% of patients reporting this issue. A study conducted at a specialised Taste [...] Read more.
Smell loss affects around 15–20% of the population, with a major effect on the quality of life. The most common complaint is the impairment of the eating experience, with around 90% of patients reporting this issue. A study conducted at a specialised Taste and Smell Clinic investigated if food and cooking can positively affect the enjoyment of food, subjective cooking skills, and quality of life in patients with smell loss. The 49 participants in the study received a 5-week cooking school course that focused on emphasizing the other senses to regain the enjoyment of food. Participants gained more confidence in cooking, and their quality of life improved significantly. Positively evaluated recipes were adjusted based on feedback and published as free e-books in Danish, German, and English. Eating and cooking are multisensory experiences, and the perception of food depends on the complex interaction of senses and surroundings. If the olfactory input is reduced or absent, both the enjoyment and cooking experience can be negatively affected. Therefore, focusing on food and cooking can have a positive impact on patients with smell loss. Full article
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14 pages, 701 KB  
Article
Building Vocabulary Bridges: Exploring Pre-Service Primary School Teachers’ Dispositions on L2 Vocabulary Instruction for Emergent Bilinguals through Interactive Book Reading
by Eline Decraene, Silke Vanparys, Maribel Montero Perez and Hilde Van Keer
Educ. Sci. 2023, 13(12), 1220; https://doi.org/10.3390/educsci13121220 - 7 Dec 2023
Cited by 1 | Viewed by 3068
Abstract
A strong vocabulary is crucial for language acquisition and can profoundly influence academic and societal success. Interactive book reading (IBR) offers an effective approach for vocabulary instruction as it provides a dynamic and engaging word-learning context. However, as children progress from preschool to [...] Read more.
A strong vocabulary is crucial for language acquisition and can profoundly influence academic and societal success. Interactive book reading (IBR) offers an effective approach for vocabulary instruction as it provides a dynamic and engaging word-learning context. However, as children progress from preschool to primary grades, the emphasis on IBR declines, despite the persistent need for comprehensive literacy education, particularly for emergent bilinguals. This study aims to uncover the reasons underlying the diminishing use of IBR and focuses on the dispositions (i.e., knowledge and beliefs) of pre-service teachers regarding L2 vocabulary instruction during IBR with emergent bilinguals. Semi-structured interviews were conducted with 36 pre-service teachers in Flanders. Thematic analysis revealed a foundational knowledge base for vocabulary instruction during IBR, with most beliefs aligning with scientific evidence. Nevertheless, some beliefs contradicted research findings, particularly concerning the deliberate use of IBR to achieve specific learning objectives, harnessing students’ home languages and fully realizing IBR’s potential for optimal vocabulary acquisition. Furthermore, preconditions at the class, school, educational policy and parental levels emerged as crucial factors for effectively implementing vocabulary instruction during IBR. These findings serve as pivotal starting points for further refining pre-service teacher education and developing in-service professional development in Flanders. Full article
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29 pages, 5612 KB  
Review
Colorectal Cancer: Disease Process, Current Treatment Options, and Future Perspectives
by Amusa S. Adebayo, Kafilat Agbaje, Simeon K. Adesina and Oluwabukunmi Olajubutu
Pharmaceutics 2023, 15(11), 2620; https://doi.org/10.3390/pharmaceutics15112620 - 12 Nov 2023
Cited by 78 | Viewed by 14010
Abstract
Colorectal cancer (CRC) is one of the deadliest malignancies in the US, ranking fourth after lung, prostate, and breast cancers, respectively, in general populations. It continues to be a menace, and the incidence has been projected to more than double by 2035, especially [...] Read more.
Colorectal cancer (CRC) is one of the deadliest malignancies in the US, ranking fourth after lung, prostate, and breast cancers, respectively, in general populations. It continues to be a menace, and the incidence has been projected to more than double by 2035, especially in underdeveloped countries. This review seeks to provide some insights into the disease progression, currently available treatment options and their challenges, and future perspectives. Searches were conducted in the PubMed search engine in the university’s online library. The keywords were “Colorectal Cancer” AND “disease process” OR “disease mechanisms” OR “Current Treatment” OR “Prospects”. Selection criteria were original articles published primarily during the period of 2013 through 2023. Abstracts, books and documents, and reviews/systematic reviews were filtered out. Of over 490 thousand articles returned, only about 800 met preliminary selection criteria, 200 were reviewed in detail, but 191 met final selection criteria. Fifty-one other articles were used due to cross-referencing. Although recently considered a disease of lifestyle, CRC incidence appears to be rising in countries with low, low–medium, and medium social demographic indices. CRC can affect all parts of the colon and rectum but is more fatal with poor disease outcomes when it is right-sided. The disease progression usually takes between 7–10 years and can be asymptomatic, making early detection and diagnosis difficult. The CRC tumor microenvironment is made up of different types of cells interacting with each other to promote the growth and proliferation of the tumor cells. Significant advancement has been made in the treatment of colorectal cancer. Notable approaches include surgery, chemotherapy, radiation therapy, and cryotherapy. Chemotherapy, including 5-fluorouracil, irinotecan, oxaliplatin, and leucovorin, plays a significant role in the management of CRC that has been diagnosed at advanced stages. Two classes of monoclonal antibody therapies have been approved by the FDA for the treatment of colorectal cancer: the vascular endothelial growth factor (VEGF) inhibitor, e.g., bevacizumab (Avastin®), and the epidermal growth factor receptor (EGFR) inhibitor, e.g., cetuximab (Erbitux®) and panitumumab (Verbitix®). However, many significant problems are still being experienced with these treatments, mainly off-target effects, toxic side effects, and the associated therapeutic failures of small molecular drugs and the rapid loss of efficacy of mAb therapies. Other novel delivery strategies continue to be investigated, including ligand-based targeting of CRC cells. Full article
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