Search Results (226)

Mono- and bis-guanyl hydrazone-functionalized tricyclic compounds were here designed and investigated as putative G-quadruplex ligands in the context of anticancer drug development. The G-quadruplex on Controlled Pore Glass (G4-CPG) assay, a fast and easy screening method based on affinity chromatography for identifying potential G-quadruplex binders, together with biophysical techniques such as circular dichroism and fluorescence spectroscopy, demonstrated a higher selectivity of mono- with respect to disubstituted derivatives in recognizing G-quadruplexes from telomeric and oncogenic DNA regions vs. duplexes. Among the mono-substituted compounds, higher G-quadruplex selectivity was found for those containing the pyrido[3,4-b]indole and dibenzofuran scaffolds compared to the 9H-fluorene, 9H-carbazole, and dibenzothiophene ones. Molecular docking studies suggested that the investigated ligands bound the hybrid telomeric G-quadruplex model by adopting a coplanar arrangement of the core and guanyl hydrazone moieties, both stacked on the 5′-G-quartet, while in the interaction with the parallel oncogenic G-quadruplex model the guanyl hydrazone moieties pointed towards the grooves/loops. Finally, biological assays highlighted the higher potential of mono-guanyl hydrazone-derivatized tricyclic compounds as selective anticancer agents, showing higher anticancer activity and selectivity of action than the bis-guanyl hydrazone derivatives. Full article

Understanding the finishing behavior of hybrid structures produced by additive manufacturing based on FDM is critically important in systems where phases with different thermal and mechanical properties coexist. In this study, the drilling performance of hybrid structures with a PLA/17-4 PH/PLA layer arrangement was comprehensively investigated in terms of thrust force, moment, surface roughness, temperature variation, vibration behavior, and surface integrity. For this purpose, a total of 16 drilling tests were performed on 56 × 56 × 15 mm hybrid specimens with 100% infill density, in a full factorial configuration, at cutting speeds (V) of 80–170 m/min and feed rates (f) of 0.04–0.16 mm/rev. The middle layer was used in the as-printed green state as a 17-4 PH metal-filled filament containing metal particles and binder, without any debinding or sintering step. The results showed that increasing feed rate increased thrust force, moment, and surface roughness in all layers, whereas increasing cutting speed decreased these values and promoted a more stable drilling regime. The middle 17-4 PH layer exhibited lower surface roughness than the outer PLA layers, while thermal measurements indicated limited variation at the hole entrance and higher temperature accumulation at the hole exit. The most favorable drilling condition within the studied hybrid configuration was obtained at 170 m/min and 0.04 mm/rev, whereas the least favorable condition was obtained at 80 m/min and 0.16 mm/rev. Overall, the combination of high cutting speed and low feed rate provided the most suitable drilling window for the studied hybrid structure. The findings also indicated that surface quality was more strongly associated with cutting load and high-frequency vibration components than with vibration level alone. Full article

New partially bio-based, waste-derived composites are manufactured from date palm surface fibers (DPSF), waste coffee filters (CFP), and disposable medical isolation gowns (MIG). These three disposable raw materials fill landfills and create an environmental problem. Therefore, the objective of this current study is to use such materials in creating promised thermal insulation and sound absorption boards. Six hybrid composites with different compositions were made using Polyvinyl acetate (PVA) wood adhesive as a binder. Three of them were made of DPSF and MIG, and the other three were composed of DPSF and the CFP. Different tests were performed on the developed composites, such as thermal conductivity measurements, sound absorption and noise reduction determination, surface morphology image analysis, thermogravimetric analysis, and three-point bending tests. The results showed that the thermal conductivity coefficients for the hybrids DPSF + MIG and DPSF + CFP are in the ranges 0.0493–0.0613 W/(m·K) and 0.052–0.065 W/(m·K), respectively, over the temperature range 24–82 °C. The sound absorption coefficient (SAC) is greater than 0.4 for all composites at frequency bands greater than 500 Hz. The noise reduction coefficient (NRC) is ≥0.45 for all composites. Surface morphology images of the composites were also reported. The results also show that the composites are thermally stable at temperatures up to 258.3 °C. The flexural modulus ranges between 5.0 and 8.46 MPa for the medical isolation gown composites and 2.49 and 5.57 MPa for the coffee filter paper composites. The hybrid composites have a lower moisture content of 0.51% to 2.5%. These promising results support the use of these composites for thermal insulation and sound absorption in building construction as alternatives to conventional thermal insulations derived from crude fuels. Full article

This research investigates the relationship between mineralogical composition and compressive strength in alkali-activated cement–sand mortars incorporating palm oil fuel ash (POFA) as a partial replacement of Portland cement. POFA was introduced at 5 wt.% and 10 wt.% of the binder, and activation was achieved using a NaOH–Na₂SiO₃ solution (3:1 mass ratio). Compressive strength and bulk density were evaluated at 7 and 28 days, while phase evolution was analyzed by X-ray diffraction (XRD) coupled with Rietveld refinement. The results demonstrate that POFA incorporation significantly modified the CaO–SiO₂–Al₂O₃ balance of the system, promoting the consumption of portlandite and the formation of Na- and K-rich aluminosilicate phases such as albite and muscovite. The control mixture exhibited the highest compressive strength values, whereas increasing POFA content reduced both strength and density due to calcium dilution, lower gel compactness, and increased porosity. Nevertheless, all mixtures exhibited progressive strength development over time, indicating continued hydration and geopolymerization reactions associated with the formation of hybrid C–(N,K)–A–S–H gels. These findings demonstrate that POFA can effectively participate in alkali-activated hybrid binders when applied at controlled replacement levels, highlighting its potential as a sustainable supplementary material for lower-carbon cementitious systems. Full article

Tool wear in CNC milling increases friction and torque demand at the tool-workpiece interface, which is reflected in spindle motor current. This study develops a non-intrusive tool wear condition classification method using spindle motor current monitoring during practical CNC milling of commercial medium-carbon steel workpieces (JIS S50C/AISI SAE 1050-equivalent; as-received and non-heat-treated; nominal laboratory hardness approximately 4.3 HRC). Experiments were performed on a Tongtai MDV-508 vertical machining center at fixed cutting conditions (3000 rpm spindle speed, 2 mm axial depth of cut, 5 mm cutting width, and 300 mm/min feed rate) using eight TiAlN-coated fine-grain WC–Co solid carbide end mills (10 mm diameter, four flutes; nominal Co binder approximately 10 wt%). An oil-based HS Highstart/HS-SSHS-BH10 cutting fluid was applied through the machine external coolant nozzle in flood mode at an estimated nominal flow rate of approximately 3 L/min and near-room coolant temperature (25 ± 2 °C), and was used as supplied without dilution. A clamp-type AC current sensor was installed on one phase line supplying the spindle motor, and current was acquired using an NI-9221 module at 20 kHz. Cutting intervals were isolated by envelope-based segmentation, concatenated, and divided into 1 s windows (0.5 s overlap) for feature extraction. Three feature sets were evaluated: time-domain statistics, frequency-domain statistics, and an FFT→PCA hybrid representation. Tool states (New, Mid-life, Old) were labeled using post-process surface roughness Ra thresholds supported by microscope observation. The PCA transformation was fitted only on training data and then applied to the held-out test data. A logistic regression classifier achieved 97.44% test accuracy (152/156 windows; 95% Wilson CI: 93.59–99.00%) with the PCA-hybrid features, outperforming time-domain (89.74%) and frequency-domain (94.87%) models. The results support spindle current monitoring as a low-cost approach for quality-aligned tool condition monitoring, while the external validity remains limited to the tested machine, material, tool, coolant, and cutting-parameter combination. Full article

Stabilizing weak soils is a well-known pavement and geotechnical engineering technique. This technique involves introducing minimal cementitious materials to improve the soil’s geotechnical characteristics. This paper investigates the use of recycled industrial polymer waste (IPW) as a reinforcement material in the presence of cementitious binders to stabilize weak silty sand soil (SM), supporting sustainable engineering practices. The randomly distributed IPW were added as percentages of 0%, 5%, and 10% to a mixture of lime soil and cement soil, with varying amounts of 0% to 6% of lime (L) and 0% to 6% of ordinary Portland cement (OPC), respectively. The laboratory experiments were conducted on natural and stabilized samples in wet (unsoaked) and submerged (soaked) conditions. The experimental program included Proctor compaction, California bearing ratio (CBR), unconfined compressive strength (UCS), durability tests, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction analyses. The resilient modulus (Mr) was estimated using an empirical equation. The outcomes of this experimental study show that adding a combination of IPW shreds with a small amount of L and/or OPC to the SM soil provides a significant increase in the UCS, CBR, durability and Mr values compared with case of SM with only L, which allows for superior characteristics and increases strength and stiffness parameters throughout any phase of earthwork construction design, resulting in stronger and stiffer subgrades. These results were reinforced by microstructural observations from SEM, EDS, and DRX, confirming the formation of cementitious gels and chemical compounds, consistent with the macro-scale mechanical improvements. The expected practical outcomes include potential reductions in pavement thickness, which can help lower pavement stabilization costs and extend its service life. Additionally, the use of waste materials to replace raw materials contributes to decreased energy consumption and emissions, although detailed assessments are needed to quantify these effects. Full article

Ultra-high-performance concrete incorporating coarse aggregates (UHPC-CA) exhibits pronounced multi-scale heterogeneity and staged damage evolution. However, existing single-scale reinforcement strategies often fail to address the complete micro-to-macro fracture process, leaving a critical research gap in achieving full-stage crack control. To address this, this study introduces a novel cross-scale toughening strategy using hybrid steel fibers (SF) and calcium carbonate whiskers (CCW), and decouples the coupled influences of water-to-binder (W/B) ratio, coarse aggregate (CA), and multi-scale fibers via an orthogonal design. Mechanical properties, fiber dispersion, and pore structure are jointly characterized to establish structure–property relationships. An optimal composition (W/B = 0.32, CA = 18%, SF = 2%, CCW = 1%) is identified, achieving a balanced enhancement of strength and ductility. Results indicate that matrix densification is primarily controlled by W/B via pore refinement, while mechanical performance is governed by the interplay between fiber spatial uniformity and interfacial integrity; the roles of CA and CCW are clearly stress-state dependent. Furthermore, a novel cross-scale synergistic mechanism is revealed, in which micro-scale CCW regulates microcrack initiation and stabilizes the pre-peak response, whereas macro-scale SF dominates post-peak behavior through crack bridging and pull-out energy dissipation. This sequential activation enables a full-stage enhancement of tensile performance, shifting failure from brittle localization to pseudo-ductile multiple cracking. The findings provide a correlative framework for tailoring UHPC-CA through multi-scale hybrid reinforcement. Full article

The aim of this research was to evaluate the efficacy of water-soluble epoxy resin (ER) in regard to stabilising clay soils, specifically for the design of column-type reinforcement in soft ground. An extensive laboratory program was conducted to assess the mechanical enhancement of a silty clay soil via ER, both as a standalone stabiliser and in combination with cement, bentonite, and sodium polyacrylate (PA). In addition, the study investigated the impacts of thermal stabilisation and electro-osmotic dewatering on resin–soil specimens. Specimens stabilised solely with ER exhibited poor strength development due to the inhibition of polymerisation by water. The addition of bentonite at low concentrations resulted in low early strength development and a moderate increase in the final strength. The use of cement provided the most significant strength gains, which were further enhanced by optimising the dosage of PA, although an excessive PA content significantly reduced the strength properties. In terms of physical treatments, thermal stabilisation at an optimal temperature of 60 °C for 24 h substantially improved the performance of ER. Electro-osmotic treatment accelerated the development of early strength but failed to provide appreciable strength improvement, and resulted in brittle behaviour and reduced toughness in the later stages (90–180 days). These findings offer critical guidelines for optimising mix designs and treatment protocols for geotechnical ground improvement projects. Full article

This study extends beyond traditional single-binder assessments by developing a mechanistic framework for interpreting the behavior of multi-component geopolymer systems. It systematically examines the roles of industrial by-products (granulated blast-furnace slag), agricultural residues (barley straw ash), and construction-derived materials (recycled granite powder) when integrated into a metakaolin-based matrix, with particular emphasis on their influence on gel formation pathways, microstructural refinement, and macroscopic performance. A sustainable geopolymer concrete (SGC) system was formulated using multi-binder combinations at replacement levels ranging from 5% to 30%. Comprehensive evaluations were conducted, including fresh properties, mechanical performance, durability characteristics, thermal resistance, and microstructural features. The results demonstrate that the 70Mk–30GBFS composition facilitates the development of a dense hybrid C–(A)–S–H/N–A–S–H gel network, resulting in a 26.8% enhancement in compressive strength and a 32.0% decrease in chloride ion penetration. Rather than depending on empirical relationships, the study establishes a mechanistically grounded link between precursor chemistry, interfacial transition zone (ITZ) refinement, and performance limits. These findings contribute to a deeper understanding of multi-component geopolymer design and support the development of high-performance, sustainable concrete materials for structural applications. Full article

Silicomanganese slag (SiMnS), a Mn-bearing by-product from silicomanganese alloy production, is often stockpiled in large quantities and may pose environmental concerns due to potential metal leaching. This study develops an OPC-rich hybrid SiMnS–steel slag–fly ash–OPC-activated composite binder, referred to as SMSAB, in which OPC accounts for 55% of the solid precursor mass. Different alkali contents and sodium silicate moduli were investigated, and the optimised paste was characterised in terms of mechanical strength, reaction products, pore structure, carbon-footprint and heavy-metal leaching. The best performance was obtained at an alkali content of 4% and a sodium silicate modulus of 1.0, giving 28-day compressive and flexural strengths of 65.13 MPa and 3.37 MPa, respectively. XRD, SEM-EDS, FTIR and MIP results showed that the main reaction products were C-(A)-S-H, N-A-S-H and C-N-A-S-H gels, which refined the pore structure and produced a dense matrix. The reduction in Mn leaching may be associated with physical encapsulation, possible charge-balancing interactions within gel structures, changes in Mn-related bonding environments and the presence of Mn-bearing phases. Leaching concentrations of Zn, Mn, Cr, Cu and Ni satisfied the Grade III groundwater limits used in China. The calculated carbon intensity of SMSAB was 3.97 kg·(m³·MPa)⁻¹, indicating a favourable strength-to-emission balance compared with the reference systems considered. It should be noted that the present work examines paste specimens only; aggregate skeleton, traffic loading, freeze–thaw cycling and wet–dry/moisture cycling were not included. Therefore, the results demonstrate binder-level potential rather than direct qualification of SMSAB as a pavement base or subbase material. Full article

The construction sector is responsible for significant global energy consumption and CO₂ emissions, largely driven by carbon-intensive materials such as ordinary Portland cement and steel. In response to increasing decarbonization and circular economy demands, several strategically relevant categories of sustainable construction materials have been developed, particularly natural and bio-based systems, recycled and waste-derived materials, low-carbon cementitious binders, and emerging multifunctional composites. However, research remains fragmented across material classes and performance metrics. This systematic review evaluates advances published between 2018 and 2026 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 methodology. Peer-reviewed studies were systematically identified and analyzed to compare mechanical performance, durability, embodied carbon reduction, and life-cycle environmental impacts across these selected material pathways. The results indicate substantial decarbonization potential. Low-carbon cementitious materials report CO₂ reductions of approximately 10–75% relative to conventional systems, while engineered timber and bamboo demonstrate 28–70% lower carbon footprints due to reduced embodied energy and biogenic carbon storage. Recycled aggregates and industrial by-products enhance circularity but remain sensitive to transport distance and processing intensity. Trade-offs between mechanical capacity and environmental performance are evident in lightweight and bio-based systems. Overall, sustainability gains are maximized through integrated hybrid construction strategies rather than isolated material substitution. This review provides a comparative evidence-based synthesis and identifies key research gaps and implementation challenges for accelerating low-carbon construction. Full article

Balancing low segment wear with stable cutting forces remains a challenge in granite sawing. This work compares diamond-impregnated saw segments produced by microwave– hybrid sintering (MWHS) and hot pressing (HP) when cutting Rosa Porriño granite. Tests were performed under tap-water cooling (22 L min⁻¹) while varying peripheral speed (20–40 m s⁻¹), feed speed (22–38 mm s⁻¹), and cutting depth (9–18 mm). Cutting forces were recorded during successive slots, and wear was quantified as mass loss per machined area (1.2–3.0 m² per test). MWHS segments exhibited lower wear than HP segments, with reductions up to ~20%, consistent with improved diamond retention and reduced binder exposure to debris-driven abrasion. Under higher cutting severity, however, MWHS segments developed higher forces, indicating reduced grit renewal and progressive blunting, plausibly linked to stronger diamond–matrix bonding and the low-friability diamond grade used. In contrast, HP segments operated at lower forces but showed higher wear, consistent with greater surface renewal through controlled grit release. Tuning diamond friability and matrix compliance in MWHS is proposed to stabilize forces while preserving the wear advantage. Overall, MWHS is a viable route for granite cutting segments, but further optimization is required to achieve HP-equivalent behavior across the tested conditions. Full article

Magnesium oxychloride cement (MOC), produced from reactive MgO and MgCl₂, has re-emerged as a promising low-carbon binder due to its rapid setting and high early-age strength. Yet its limited resistance to moisture and immersion remains the principal barrier to broader construction deployment. This review synthesizes the MOC evidence base using a structured approach that combines PRISMA-informed study identification and screening with bibliometric mapping to contextualize research evolution and thematic development. The review follows a structured data extraction of mix design, curing conditions, characterization methods, and performance outcomes. The synthesis confirms that MOC performance is strongly system-dependent. MgO reactivity, MgCl₂ concentration, mixture ratios, and curing regime govern hydration products, microstructure, and durability, accounting for the apparent variation across studies. Comparative assessment shows that improvements in water resistance are most consistently reported for phosphate-based modification, SCM incorporation, and polymer/hybrid strategies. However, benefits are frequently accompanied by trade-offs in workability, setting, strength development, and cost, and reinforcement compatibility and corrosion risk remain insufficiently resolved for structural applications. The review highlights gaps in reporting and durability testing that currently limit cross-study comparability and translation, and it consolidates priority research directions toward standardized protocols, mechanism-based durability design, scale-up validation, and robust sustainability assessment. Full article

This study evaluates the potential of using Granulated Waste Tire Rubber (GWTR) as an alternative raw material in geopolymer mortars an eco-friendly, low-carbon alternative to traditional cement-based systems. The research investigates the synergistic effect of industrial by-products, such as slag (from ferrochrome plants) and fly ash (from thermal power plants), combined with varying proportions of GWTR (1/4, 1/3, and 1/2 by volume). A total of 22 mixtures were prepared using diverse binder pastes, including pure cement, slag-based, and fly ash-based geopolymer systems, alongside their cement-substituted derivatives. The mechanical and physical performances were assessed through compressive strength, flexural strength, and Ultrasonic Pulse Velocity (UPV) tests at 3, 7, 28, and 180 days, complemented by SEM microstructural analyses. The findings indicate that while GWTR significantly reduces the mechanical properties of pure cement matrices, this negative impact is substantially mitigated in geopolymer mortars supplemented with 5–10% cement. Mixtures containing 1/4 GWTR with 90–95% slag or fly ash (M6, M7, M15, M16) yielded the most successful results in terms of both strength and sustainability, specifically, mixtures M7 and M16 because the hybrid binder synergy effectively compensated for the rubber-induced porosity, ensuring a denser matrix and structural-grade compressive strength alongside high sustainability. Significant decreases in performance were observed at higher GWTR ratios, particularly at the 1/2 level. Overall, the study demonstrates that integrating GWTR into optimized geopolymer systems offers a viable pathway for the valorization of environmental waste and minimizing the ecological footprint of the construction industry. Full article

This study investigates the combined effect of incorporating recycled concrete aggregates (RCAs) and glass fibers (GFs) on the properties of geopolymer concrete. The precursor binder consisted of a blend of ground granulated blast furnace slag and fly ash. Furthermore, two types of GFs (i.e., short and long) were incorporated, either individually or in hybrid combinations, to enhance the performance of the concrete. Experimental results revealed that replacing natural aggregates (NAs) with RCAs in geopolymer concrete production had no tangible impact on workability but resulted in a slight reduction in the density, ultrasonic pulse velocity, and bulk resistivity. Similarly, the compressive strength and modulus of elasticity decreased by up to 18 and 57%, respectively. Meanwhile, the addition of GFs, particularly in hybrid configurations, effectively mitigated these reductions. Among the hybrid mixtures, a short-to-long fiber ratio (A:B) of 1:3 yielded the most significant improvements of the physical, mechanical, and durability properties, with increases of up to 16%, 91%, and 61%, respectively. Several correlation equations were established to describe the relationships between the physical, mechanical, and durability properties of GF-reinforced geopolymer concrete and were compared with existing codified models. The outcomes provide critical insights into the synergistic roles of RCA and GFs in tailoring high-performance, eco-efficient concrete systems. This research supports the advancement of sustainable concrete production and promotes the broader structural adoption of geopolymer technologies. Full article