Search Results (2,502)

Large language models (LLMs) often tend to hallucinate, especially in domain-specific tasks and tasks that require reasoning. Previously, we introduced SubGraph Retrieval Augmented Generation (SG-RAG) as a novel Graph RAG method for multi-hop question answering. SG-RAG leverages Cypher queries to search a given knowledge graph and retrieve the subgraph necessary to answer the question. The results from our previous work showed the higher performance of our method compared to the traditional Retrieval Augmented Generation (RAG). In this work, we further enhanced SG-RAG by proposing an additional step called Merging and Ordering Triplets (MOT). The new MOT step seeks to decrease the redundancy in the retrieved triplets by applying hierarchical merging to the retrieved subgraphs. Moreover, it provides an ordering among the triplets using the Breadth-First Search (BFS) traversal algorithm. We conducted experiments on the MetaQA benchmark, which was proposed for multi-hop question-answering in the movies domain. Our experiments showed that SG-RAG MOT provided more accurate answers than Chain-of-Thought and Graph Chain-of-Thought. We also found that merging (up to a certain point) highly overlapping subgraphs and defining an order among the triplets helped the LLM to generate more precise answers. Full article

Opportunistic Networks (OppNets) lack the capability to maintain consistent end-to-end paths between source and destination nodes, unlike Mobile Ad Hoc Networks (MANETs). This absence of stable routing presents substantial challenges for data transmission in OppNets. Due to node mobility, routing paths are inherently dynamic, requiring the selection of neighboring nodes as intermediate hops to forward data toward the destination. However, frequent node movement can cause considerable delays for senders attempting to identify appropriate next hops, consequently degrading the quality of service (QoS) in OppNets. To mitigate this challenge, this paper proposes an alternative approach for scenarios where senders cannot locate suitable next hops. Specifically, we propose utilizing direct communication via line of sight (LoS) between sender and receiver nodes to satisfy QoS requirements. The proposed scheme is experimented with using the ONE simulator, which is widely used for OppNet experiments and study, and compared against existing schemes such as the history-based routing protocol (HBRP) and AEProphet routing protocol. Full article

Background/Objectives: Humulus lupulus (hops) are a perennial, dioecious plant widely cultivated for beer production, used for their distinguishing aroma and bitterness—traits that confer high added value status. Various hop-derived compounds have been reported to exhibit antioxidant, antimicrobial, antiproliferative and other bioactive effects. This systematic review and meta-analysis assesses the impact of hop compounds on the viability of diverse cancer cell lines. Methods: A comprehensive literature search was performed following PRISMA guidelines. Data were synthesized via multivariate meta-analysis and meta-regression, using IC₅₀ values as the effect size. Key variables included assay type (SRB, tetrazolium salt-based, crystal violet), exposure duration (24, 48, 72 h), specific hop compound and cancer cell line. Results: Of 622 articles identified, 61 met eligibility criteria, yielding 354 individual experiments. Meta-regression of xanthohumol (XN) IC₅₀ values across SRB, tetrazolium and crystal violet assays revealed no statistically significant differences at 24 h (p = 0.77), 48 h (p = 0.35) and 72 h (p = 0.70), supporting the interchangeability of the methods. Meta-analysis confirmed that hop constituents inhibit cancer cell proliferation; XN emerged as the most potent flavonoid (IC₅₀ = 16.89 μM at 72 h), while lupulone was the strongest compound overall (IC₅₀ = 5.00 μM at 72 h). Crude hop extracts demonstrated greater antiproliferative selectivity for cancer versus non-cancer cells (IC₅₀ = 35.23 vs. 43.80 μg/mL at 72 h). Conclusions: Hop compounds, and particularly bitter acids, demonstrate promising antiproliferative activity against cancer cells with comparatively low toxicity to healthy cells. Furthermore, our analysis confirms the comparability of SRB, tetrazolium-based and crystal violet assays, supporting the robust integration of antiproliferative data. Full article

Given the high neuromechanical demands and frequent asymmetries in badminton, this study investigated the impact of a four-week asymmetry-targeted intervention on single-leg hop performance in elite junior badminton players and examined whether asymmetry-based indices could predict training responsiveness. Twenty-two national-level athletes (aged 15–18) were randomized into an experimental group (EG) undergoing neuromechanical training with EMG biofeedback or a control group (CG) following general plyometric exercises. Key performance metrics—Jump Height, Reactive Strength Index (RSI), Peak Power, and Active Stiffness—were evaluated pre- and post-intervention. Two novel composite indices, Force Efficiency Ratio (FER) and Asymmetry Impact Index (AII), were computed to assess force production efficiency and asymmetry burden. The EG showed significant improvements in Jump Height (p = 0.030), RSI (p = 0.012), and Peak Power (p = 0.028), while the CG showed no significant changes. Contrary to initial hypotheses, traditional asymmetry metrics showed no significant correlations with performance variables (r < 0.1). Machine learning models (Random Forest) using FER and AII failed to classify responders reliably (AUC = 0.50). The results suggest that targeted interventions can improve lower-limb explosiveness in youth athletes; however, both traditional and composite asymmetry indices may not reliably predict training outcomes in small elite groups. The results highlight the need for multidimensional and individualized approaches in athlete diagnostics and training optimization, especially in asymmetry-prone sports like badminton. Full article

Frequency-hopping multiple access is widely adopted to blunt narrow-band jamming and limit spectral disclosure in cyber–physical systems, yet its practical resilience depends on three sequence-level properties. First, balancedness guarantees that every carrier is occupied equally often, removing spectral peaks that a jammer or energy detector could exploit. Second, a wide gap between successive hops forces any interferer to re-tune after corrupting at most one symbol, thereby containing error bursts. Third, a no-hit zone (NHZ) window with a zero pairwise Hamming correlation eliminates user collisions and self-interference when chip-level timing offsets fall inside the window. This work introduces an algebraic construction that meets the full set of requirements in a single framework. By threading a permutation over an integer ring and partitioning the period into congruent sub-blocks tied to the desired NHZ width, we generate balanced wide gap no-hit zone frequency-hopping (WG-NHZ FH) sequence sets. Analytical proofs show that (i) each sequence achieves the Lempel–Greenberger bound for auto-correlation, (ii) the family and zone sizes satisfy the Ye–Fan bound with equality, (iii) the hop-to-hop distance satisfies a provable WG condition, and (iv) balancedness holds exactly for every carrier frequency. Full article

This paper proposes a multi-hop peer-to-peer (P2P) video streaming architecture designed to support dynamic, conversation-aware communication. The primary contribution is a decentralized system built on WebRTC that eliminates reliance on a central media server by employing super node aggregation. In this architecture, video streams from multiple peer nodes are dynamically routed through a group of super nodes, enabling real-time reconfiguration of the network topology in response to conversational changes. To support this dynamic behavior, the system leverages WebRTC data channels for control signaling and overlay restructuring, allowing efficient dissemination of topology updates and coordination messages among peers. A key focus of this study is the rapid and efficient reallocation of network resources immediately following conversational events, ensuring that the streaming overlay remains aligned with ongoing interaction patterns. While the automatic detection of such events is beyond the scope of this work, we assume that external triggers are available to initiate topology updates. To validate the effectiveness of the proposed system, we construct a simulation environment using Docker containers and evaluate its streaming performance under dynamic network conditions. The results demonstrate the system’s applicability to adaptive, naturalistic communication scenarios. Finally, we discuss future directions, including the seamless integration of external trigger sources and enhanced support for flexible, context-sensitive interaction frameworks. Full article

Background and Objectives: Although the use of allografts in revision anterior cruciate ligament reconstruction is associated with theoretical advantages, it has historically led to poorer clinical results and lower survival rates. However, the heterogeneity of the available literature makes it difficult to elucidate the effectiveness of allographs, as most of the studies published do not make any reference to some of the key aspects related to the processing of the allograft employed. The present study analyzed the clinical results and the survival of allografts in patients undergoing revision anterior cruciate ligament reconstruction with a well-characterized, single type of allograft. Materials and Methods: This was a retrospective observational study analyzing a series of patients undergoing revision anterior cruciate ligament reconstruction with an Achilles tendon allograft with a bone block (FlexiGraft, LifeNet Health), subjected to low-dose irradiation at dry ice temperatures. Preoperative and follow-up clinical variables (IKDC, pain, hop test, and YBT scores) were recorded. Survival was analyzed using the Kaplan–Meier methodology. Results: A total of 39 patients (34 male, 5 female) were included in the study. The mean patient age was 37.3 years and mean postoperative follow-up was 78.7 months. Forty-one percent of patients were competitive athletes, and all of the patients in the sample exhibited preoperative instability. The mean allograft thickness was 9.2 mm. During surgery, 51.3% of patients required meniscus repair and 20.5% had to be treated for chondral defects. At the last follow-up visit, 92.3% of the subjects presented with IKDC grade A and 7.7% with IKDC grade B. The mean subjective IKDC score was 0.79 and mean pain intensity was 1.15 according to the VAS scale. Limb symmetry, as measured by the various hop tests and the Y balance test, were within the safety range, with 74.4% of patients succeeding in returning to their previous level of sport. Ten-year survival was estimated at 97.4%. Conclusions: Allografts obtained and processed following the current regulations governing patient selection and graft harvesting, which are additionally processed without recourse to chemical procedures and sterilized at less than 2 MRad in dry ice conditions, represent an effective and safe alternative in revision anterior cruciate ligament reconstruction. Full article

In this paper, we propose the Adaptive Power-Controlled Energy-Efficient Depth-Based Routing (APC-EEDBR) protocol. This protocol is designed to address the challenges posed by complex environments and limited resources in underwater-sensor networks. Employing a dual-weight adjustment mechanism and adaptive power control enables the protocol to achieve energy-efficient relay selection and enhance the link stability. The protocol adopts a cluster-free, hop-by-hop communication strategy and a cross-layer design to improve path stability and forwarding efficiency while mitigating hotspot issues in data aggregation areas. The simulation results demonstrate that the APC-EEDBR protocol effectively reduces energy consumption and communication overhead by approximately 16%, and significantly prolongs the network lifetime by about 39% compared with EEDBR. Full article

Vanillin photoinduced deprotonation was evaluated and analyzed. Vibronic states and transitions were computationally investigated. Optimizations and vertical electron transitions in the gas phase and with the continuum solvation model were computed using the time-dependent density functional theory. Static absorption and emission (photostatic optical) spectra were statistically averaged over the excited instantaneous molecular conformers fluctuating on quantum–classical molecular dynamic trajectories. Photostatic optical spectra were generated using the hybrid quantum–classical molecular dynamics for explicit solvent models. Conical intersection searching and nonadiabatic molecular dynamics simulations defined potential energy surface propagations, intersections, dissipations, and dissociations. The procedure included mixed-reference spin–flip excitations for both procedures and trajectory surface hopping for photodynamics. Insignificant structural deformations vs. hydroxyl bond cleavage followed by deprotonation were demonstrated starting from different initial structural conditions, which included optimized, transition state, and several other important fluctuating configurations in various environments. Vanillin electronic structure changes were illustrated and analyzed at the key points on conical intersection and nonadiabatic molecular dynamics trajectories by investigating molecular orbital symmetry and electron density difference. The hydroxyl group decomposed on transition to a σ-molecular orbital localized on the elongated O–H bond. Full article

The paper concerns a study of drying and the creation of a statistical model for measuring the relative humidity of the drying environment in a belt dryer, as well as the moisture content of hop heads, stems, and bracts. The SAAZ variety was used, which is widely cultivated in the Czech Republic, and the data from harvesting seasons since 2017 were recorded. The findings demonstrated the influence and dependence of the moisture content of hop cones and their parts on the relative humidity of the drying environment in a belt dryer of hops. This dependence was confirmed by a statistical analysis of the measured values. Furthermore, a quadratic model was developed based on measurements taken over three harvest seasons. The model is applicable to predict the moisture content of the hops at a given location based on the relative humidity of the drying environment in the belt dryer and could be useful for developing an automatic hop-drying system. Full article

Heterogeneous information network (HIN) embedding transforms multi-type nodes into low-dimensional vectors to preserve structural and semantic information for downstream tasks. However, it struggles with multiplex networks where nodes connect via diverse semantic paths (metapaths). Information fusion mainly improves the quality of node embedding by fully exploiting the structure and hidden information within the network. Current metapath-based methods ignore information from intermediate nodes along paths, depend on manually defined metapaths, and overlook implicit relationships between nodes sharing similar attributes. Our objective is to develop an adaptive framework that overcomes limitations in existing metapath-based embedding (incomplete information aggregation, manual path dependency, and ignorance of latent semantics) to learn more discriminative embeddings. We propose an adaptive multi-hop neighbor information fusion model for heterogeneous network embedding (ANHNE), which: (1) autonomously extracts composite metapaths (weighted combinations of relations) via a multipath aggregation matrix to mine hierarchical semantics of varying lengths for task-specific scenarios; (2) projects heterogeneous nodes into a unified space and employs hierarchical attention to selectively fuse neighborhood features across metapath hierarchies; and (3) enhances semantics by identifying potential node correlations via cosine similarity to construct implicit connections, enriching network structure with latent information. Extensive experimental results on multiple datasets show that ANHNE achieves more precise embeddings than comparable baseline models. Full article

Phosphatidylinositol 3-kinase alpha (PI3Kα) is frequently mutated in head and neck squamous cell carcinoma (HNSCC), leading to the constitutive activation of the PI3K/Akt pathway, which promotes tumor cell proliferation, survival, and metastasis. PI3Kα allosteric inhibitors demonstrate therapeutic potential as both monotherapy and combination therapy, particularly in patients with PIK3CA mutations or resistance to immunotherapy, through the precise targeting of mutant PI3Kα. Compared to ATP-competitive PI3Kα inhibitors such as Alpelisib, the allosteric inhibitor RLY-2608 exhibits enhanced selectivity for mutant PI3Kα while minimizing the inhibition of wild-type PI3Kα, thereby reducing side effects such as hyperglycemia. To date, no allosteric PI3Kα inhibitors have been approved for clinical use. To develop novel PI3Kα inhibitors with improved safety and efficacy, we employed a scaffold hopping approach to structurally modify RLY-2608 and constructed a compound library. Based on the structural information of the PI3Kα allosteric site, we conducted the systematic virtual screening of 11,550 molecules from databases to identify lead compounds. Through integrated approaches, including molecular docking studies, target validation, druggability evaluation, molecular dynamics simulations, and metabolic pathway and metabolite analyses, we successfully identified a promising novel allosteric PI3Kα inhibitor, H-18 (3-(2-chloro-5-fluorophenyl)isoindolin-1-one). H-18 has not been previously reported as a PI3Kα inhibitor, and provides an excellent foundation for subsequent lead optimization, offering a significant starting point for the development of more potent PI3Kα allosteric inhibitors. Full article

Numerous protocols have emerged to address the energy depletion problem in Wireless Sensor Networks (WSNs). Among these protocols, the Dynamic Multi-Hop Routing (DMR) protocol adopts a dynamic technique for routing data across the network. The use of the DMR protocol has shown promising results in reducing energy consumption, prolonging the network lifetime, and increasing throughput. To improve the performance of WSNs, this paper proposes the Enhanced Dynamic Multi-Hop Routing (EDMR) protocol as a modification of the DMR protocol. The EDMR protocol introduces an effective sleeping mechanism that selectively deactivates clusters that do not generate significantly updated data for a specific duration. This mechanism reduces redundant transmissions, thereby saving energy and prolonging the network lifetime. The EDMR protocol incorporates static and dynamic approaches to support two major categories of applications: monitoring and event-driven applications. The proposed protocol is evaluated against the DMR protocol, the Enhanced Dynamic Multi-Hop Technique (EMDHT-LEACH) protocol, and the Low-Energy Adaptive Clustering Hierarchy (LEACH) protocol. The simulation results demonstrate that the EDMR protocol mitigates energy depletion, extends the network lifetime, increases stability, and improves network throughput toward the Base Station (BS), while reducing packet redundancy compared with the other protocols. Full article

Identifying and eliminating critical links in multi-hop networks is essential for enhancing overall network resilience. In this study, we propose a novel algorithm to detect links that significantly impact the pairwise connectivity of multi-hop networks. We formulate the critical link detection problem as minimizing pairwise connectivity subject to a total edge weight constraint c. The proposed method first computes the maximum flow between neighboring nodes to evaluate strong connections, and then progressively contracts these nodes to expose weaker connections. Throughout this iterative process, the algorithm records previously identified flows to minimize redundant flow computations. At each step, it also keeps track of the cut sets that reduce the network’s pairwise connectivity. Ultimately, it selects the subset of these cut sets whose removal minimizes pairwise connectivity while satisfying the total weight constraint c. This approach consistently identifies fewer yet more impactful critical edges than traditional Min-Cut or Greedy strategies. We evaluate the performance of our method against existing algorithms across various network sizes and node degrees. Experimental results show that the proposed method consistently discovers more influential edges and achieves a 34–38% reduction in pairwise connectivity, outperforming Greedy (22–24%), Min-Cut (24–32%), and Degree-based (12–19%) methods. Full article