Search Results (3,009)

This study explores the concept of spiritual intelligence from an evolutionary perspective, providing a comprehensive and updated definition. A concept analysis was conducted following Rodgers’ Evolutionary Method, supported by a scoping review in accordance with the Joanna Briggs Institute methodology. Studies explicitly addressing spiritual intelligence, regardless of population, setting, or discipline, were included across quantitative, qualitative, mixed-methods, and review designs. Four databases—PsycINFO, PubMed Central, Scopus, and Web of Science—were searched for publications up to 15 December 2025, using the term “spiritual intelligence.” One-hundred-twelve articles met inclusion criteria and were analyzed through narrative synthesis and inductive analytical processing. Spiritual intelligence emerged as a construct encompassing adaptive cognition, higher consciousness, problem management, and personal growth, often referred to as Spiritual Quotient or Existential Intelligence. Antecedents included self and transcendental awareness, existential questioning, and search for meaning and purpose, while consequents comprised enhanced health, performance, self-awareness, and humanitarian orientation. Defining attributes were equanimity, life-wisdom, transcendental awareness, spiritual consciousness, meaning and purpose creation, and existential questioning. This evolutionary analysis traced the concept from theory to application, revealing its positive influence in daily life. Equanimity and life-wisdom were identified as core attributes, highlighting implications for training and integration of spiritual care in professional practice. Full article

Purpose: Breast cancer (BC) incidence has been increasing rapidly in North Africa, including Morocco, yet evidence regarding modifiable lifestyle factors remains limited. This study aimed to assess the associations between physical activity, sedentary behavior, daily work habits, and BC risk among Moroccan women, addressing an important gap in regional data. Methods: We conducted a case–control study between 2019 and 2023, including 1400 histologically confirmed incident BC cases and 1400 matched controls. Physical activity was assessed across the lifespan, considering type, intensity, and duration. Associations with BC risk were estimated using adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Results: Moderate physical activity was inversely associated with BC risk, showing a clear dose–response relationship. Compared with the lowest physical activity level, the highest quartile showed significantly lower odds of BC (aOR = 0.37 (95% CI: 0.29–0.47). Vigorous physical activity during young adulthood and mid-adulthood was similarly linked to reduced risk. Active daily habits, such as walking and regular stair climbing, were associated with lower odds, whereas frequent occupational fatigue and sweating were linked to increased risk. Conclusions: Our findings highlight a significant inverse association between physical activity and BC risk among Moroccan women. Notably, moderate PA and active daily habits like brisk walking are linked to lower odds of the disease. While these findings support the role of physical activity as an important factor associated with breast cancer prevention, the retrospective design of the study limits causal inference. Full article

Background: Caloric restriction (CR) is a dietary intervention based on limiting calories relative to the basic energy needs of the organism, which changes the intensity of metabolism, causes changes in the functioning of the endocrine and sympathetic systems, and influences the expression of genes in muscle, heart, and brain cells. During the use of CR, there is a transition from carbohydrate supply to increased fat metabolism. Fatty acids are more or less susceptible to free radicals, depending on their molecular structure. Oxidation (peroxidation) contributes to the production of metabolites (including hydroxyeicosatetraenoic acid and hydroxyoctadecadienoic acid), some of which are involved in inflammation. Methods: The aim of this study was to evaluate the effects of long-term caloric restriction on the tissue levels of selected fatty acids and fatty acid-derived lipid mediators with pro-inflammatory or anti-inflammatory properties in skeletal muscle and intestinal tissues. The study was carried out on C57BL/6 mice. During the 8-month experiment, the mice in the study group were fed a 30% calorie restricted diet—according to the Every-Other-Day Diet concept. Analyses were performed on intestinal and muscle tissues collected from animals. Fatty acid derivatives were isolated using solid-phase extraction (C-18 columns) columns, and isolation of fatty acids was performed using a modified Folch method. The compounds were analyzed by liquid and gas chromatography. Results: CR induced detectable alterations in both fatty acid profiles and lipid mediator concentrations in a tissue-specific manner. However, most of these changes did not remain statistically significant after multiple testing correction. Conclusions: These findings suggest potential effects of long-term CR on lipid signaling pathways, although the current dataset lacks the statistical power required to draw definitive conclusions. This study highlights the need for further research using larger sample sizes and integrated multiomic approaches to elucidate the molecular mechanisms underlying lipidomic adaptations to prolonged caloric restriction. Full article

Clear aligners are a popular alternative to fixed orthodontic appliances; however, technical data on the optimal final aligner shell thickness for directly printed aligners remain limited. This in vitro experimental pilot study evaluated the mechanical response of patient-specific, directly 3D-printed aligners of four nominal shell thicknesses (0.04, 0.06, 0.08, and 0.10 mm) fabricated from BioMed Clear resin. A single subject with dental crowding was scanned and a set of aligner shells was designed and printed (n = 3 per thickness). Compressive tests up to 1000 N were performed and compressive extension (mm) recorded; group means ± SD were compared by means of one-way ANOVA. No statistically significant differences in compressive extension were found among the four thickness groups (ANOVA, F(3,8) = 2.242, p = 0.161). The 0.08 mm group showed a lower mean compressive extension in this dataset, but the difference did not reach statistical significance; given the small sample size and single-subject nature of the study, this result should be considered exploratory. This recent study clarifies printing and post-processing parameters and highlights limitations and directions for future work. Full article

Objective: This study evaluated the effects of a 12-week High-Intensity Functional Training (HIFT) program combined with thylakoid supplementation on plasma adipo-myokine levels (Decorin, Myostatin, Follistatin, Activin A, and TGF-β1) in men with obesity. Secondary outcomes included anthropometric indices, lipid profiles, and insulin resistance markers. Methods: Sixty men with obesity (age: 27.6 ± 8.4 years; BMI: 32.6 ± 2.6 kg/m²) were randomly assigned to four groups (n = 15 per group): Placebo (PG), Supplement (SG), HIFT + placebo (TPG), and HIFT + supplement (TSG). To ensure robustness against the 27% attrition rate, statistical analyses included both per-protocol and intention-to-treat (ITT) models. HIFT was performed for 3 sessions/week (Borg scale: 15–17). Results: Following Bonferroni correction for multiple endpoints, repeated-measures ANOVA showed significant Time × Group interactions for most adipo-myokines and metabolic markers. Both training groups (TPG and TSG) demonstrated improvements in body composition and insulin sensitivity compared to PG (p < 0.05). While no significant differences were observed between TPG and TSG for systemic metabolic markers, preliminary data suggested that thylakoid supplementation might provide modest complementary modulations in specific myokines (e.g., decorin and follistatin). However, these observed trends did not reach clinical superiority over exercise alone in the broader metabolic profile. Conclusions: Twelve weeks of HIFT is an effective primary driver for modulating the adipo-myokine network in obese men. Although thylakoid supplementation showed potential for selective complementary effects on certain myokines, these findings are exploratory given the small sample size. The clinical significance and long-term complementary value of thylakoid-exercise interactions require further validation in larger, more diverse cohorts. Full article

Background/Objectives: Cephalosporins represent one of the most important classes of β-lactam antibiotics, widely used in clinical practice due to their broad-spectrum activity and favorable safety profile. As generations evolved, structural modifications were introduced to expand antimicrobial coverage and overcome β-lactamase resistance. This study aimed to analyze the drug-like properties of cephalosporins across different generations using molecular descriptors to identify structural and pharmacokinetic patterns influencing bioavailability and oral administration profiles. Methods: Thirty-eight cephalosporins representative of different generations were selected. Molecular data were obtained from PubChem, and SMILES were extracted and validated. Molecular descriptors (including MW, logP, TPSA, HBA, HBD, rotatable bonds, and global complexity indices) were calculated using the SwissADME and ChemDes platforms. Statistical analysis included ANOVA followed by post hoc tests, and principal component analysis (PCA). Results: A progressive increase in molecular weight, polarity, and TPSA was observed across generations, with fourth-generation cephalosporins showing significantly higher values compared to first-generation compounds (p < 0.0001). LogP decreased significantly in fourth-generation agents (p < 0.0001), reflecting increased polarity. PCA revealed that most compounds from generations 1–2 cluster in regions consistent with Lipinski’s and Veber’s rules, whereas fourth- and fifth generation - cephalosporins deviated substantially, prioritizing antimicrobial efficacy over oral bioavailability. Recurrent structural modifications such as oximes, tetrazoles, and aminothiazoles were identified, with increasing frequency in modern generations. Conclusions: The evolution of cephalosporins reflects a strategic shift toward enhanced antimicrobial potency and β-lactamase stability at the expense of oral bioavailability. Understanding these structural transitions provides valuable insights for rational drug design, aiming to balance antimicrobial effectiveness with favorable pharmacokinetic profiles essential for therapeutic success. Full article

The influence of competitive standards on physical performance in professional football remains controversial, particularly when teams from different divisions compete against each other. This study aimed to analyze position-specific differences in physical performance, both in possession and out of possession, between Spanish First and Second Division teams during direct competition. Match data from 25 Copa del Rey fixtures across three seasons were analyzed using a validated multi-camera tracking system. Physical performance variables were examined according to playing position. First Division players accumulated greater total distance during in-possession phases, particularly central defenders (CDs), wide defenders (WDs), central midfielders (CMs), and wide midfielders (WMs), whereas Second Division players covered greater distances during out-of-possession phases, mainly CDs, WDs, and CMs. In addition, First Division CMs exhibited higher high-speed running in possession, while Second Division forwards (FWs) demonstrated greater high-speed running and defensive high-speed running. Differences in maximum velocity were also observed in CDs, with higher values recorded in the First Division. Overall, these findings indicate that physical performance is modulated by the competitive standard and playing position. However, the interpretation of these differences should not be dissociated from the tactical nature of football, as players’ specific positions and the tactical roles derived from them may condition the physical demands imposed during different phases of play, rather than reflecting isolated physical capacity. Full article

Background: Dementia is a growing global public health concern and identifying modifiable risk and protective factors is crucial for its prevention. Fruits and vegetables, due to their antioxidant and anti-inflammatory properties, may offer neuroprotective benefits. This study aims to investigate the prevalence of adequate fruit and vegetable consumption and its association with dementia and cognitive impairment no dementia (CIND) in individuals aged 50 years and older. Methods: This cross-sectional, population-based study analysed data from 2865 participants in the second wave (2019–2021) of the Brazilian Longitudinal Study of Ageing (ELSI-Brazil). CIND was defined as a global cognitive Z-score ≤ −1.5, and dementia as cognitive decline with impairment in at least one instrumental activity of daily living. Adequate consumption of fruits, vegetables, and both combined (FV) was defined as daily intake on all seven days of the week. Associations were assessed using multivariate Poisson regression models, with prevalence ratios (PRs) and 95% confidence intervals (CIs). Results: The study sample consisted of 2865 participants. The prevalence of adequate fruit consumption was 58.08% (95% CI: 56.3–59.9), vegetables 44.14% (95% CI: 42.31–45.9), and FV 32.18% (95% CI: 30.5–33.9). Adequate vegetable consumption was significantly associated with CIND (PR: 0.19; 95% CI: 0.07–0.50; p < 0.001), while adequate fruit consumption was associated with higher prevalence of CIND (PR: 1.47; 95% CI: 1.22–1.77) and FV (PR: 0.20; 95% CI: 0.07–1.58; p = 0.003). No significant association was observed between fruit, vegetable, and FV consumption and dementia. Conclusions: Adequate vegetable and combined FV consumption were protective against CIND, though not associated with dementia. Nonetheless, overall adequate intake remains low in older Brazilian adults. Full article

Background and Objectives: Rheumatoid arthritis (RA) is a multisystem autoimmune disease that needs immunosuppressive treatment. Previously, studies have shown an increased risk of cancer in patients with RA compared with the general population. The purpose of this study was to explore the associations between RA and cancer risk, providing updated insights into the incidence of specific cancers in patients with RA. Materials and Methods: A total of 746 cancer cases were observed, with the most common types being nonmelanoma skin cancer (139 cases), breast cancer (87 cases), lung cancer (47 cases), and Hodgkin lymphoma (43 cases). Results: Compared with the general Lithuanian population, patients with RA had an increased overall cancer risk, with an SIR of 1.17 and 95% CI of 1.09–1.26. Hematological cancers and nonmelanoma skin cancers were the most common types of cancer in the RA population, and patients with RA had a significantly greater risk of site-specific cancers (non-Hodgkin lymphoma: SIR 4.19, 95% CI 1.57–11.18; Hodgkin lymphoma: SIR 3.03, 95% CI 2.11–4.36; myeloma: SIR 3.00, 95% CI 1.84–4.90; leukemia: SIR 2.39, 95% CI 1.62–3.54; and skin nonmelanoma: SIR 1.54, 95% CI 1.27–1.83). Male patients with RA had an increased risk of prostate and kidney cancer (SIR 1.40, 95% CI 1.12–1.75; SIR 1.85, 95% CI 1.11–3.06). Our study revealed a significantly lower risk of colorectal cancer among patients with RA. Additionally, we observed a statistically significant reduction in the risk of mouth and pharynx cancers; however, this finding was based on only three observed cases. Conclusions: Patients with RA remain particularly affected by an increased cancer risk. Knowing these risks, we need clear recommendations for specific screenings in patients with RA, which could allow for early diagnosis and better cancer treatment in the early stages. Full article

Background: The common fat mass and obesity-associated (FTO) gene variant rs9939609 has been linked to elevated risk of obesity and Type 2 diabetes mellitus (T2DM). Eating and sleeping windows gained clinical interest as factors in weight maintenance and have been linked to T2DM risk. Objective: To study the association and interaction between the common FTO rs9939609 variant and eating and sleeping windows to affect T2DM risk in a large community cohort. Methods: This cross-sectional study included 12,254 adult participants. Genetic, anthropometric, and lifestyle behaviors data including eating and fasting windows were analyzed. Logistic and linear regression models, as well as chi-square tests, were applied under additive, dominant, and recessive genetic models (adjusted for age, sex, and BMI). Results: Significant associations between FTO rs9939609 x eating and sleeping window interactions were demonstrated in relation to T2DM risk. Longer eating windows and later last meal timing were associated with an increased risk for T2DM under the additive model (OR = 1.029, 95% CI = 1.002–1.055, and OR = 1.066, 95% CI = 1.012–1.122, respectively), while longer fasting windows were found to be protective under additive model (OR = 0.972, 95% CI = 0.947–0.998). Later bedtime onset was associated with an increased risk for T2DM under additive model (OR = 1.101, 95% CI = 1.005–1.220). Hours of night sleep significantly interacted with FTO rs9939609 under additive genetic model. FTO rs9939609 risk allele carriers with prolonged sleeping windows (OR = 1.137, 95% CI = 1.039–1.354) and poorer sleeping quality (OR = 1.185, 95% CI = 1.038–1.354) had increased risk of T2DM. Conclusions: Eating and fasting windows, late last meal timing, hours of night sleep, late bedtime onset, and poorer sleep quality are significantly associated with T2DM risk among FTO rs9939609 risk carriers and may reflect metabolic vulnerability associated with FTO risk alleles. These findings highlight potential behavioral modification to attenuate genetic risk and provide evidence for actionable prevention strategies in genetically predisposed populations. Full article

Background: Atopic dermatitis (AD) is a chronic, pruritic and relapsing inflammatory skin disorder affecting children’s quality of life (QoL). Despite rising global prevalence, data on its impact on QoL in low-resource settings remain limited. This study aimed to assess the impact of AD and associated factors on the QoL of children and assesses the effect of educational intervention in Ethiopia. Methods: A prospective cohort study was conducted among 461 AD children and their caregivers across four randomly selected hospitals dermatology clinics in Ethiopia from October 2022 to March 2024. Assessments included AD Severity using Scoring Atopic Dermatitis (SCORAD), Infants’ Dermatitis Quality of Life Index (IDLQI) for children aged 0–4, and Children’s Dermatology Life Quality Index (CDLQI) for children aged 5 to 16. Participants received educational guidance from trained nurses during follow-up beyond routine AD treatment. Trained personnel collected clinical and sociodemographic data. AD severity and QoL were reassessed after 6 months. Descriptive, univariate, and linear regression analyses identified factors influencing QoL, with associations reported as odds ratios (95% CI) and significance set at p < 0.05. Results: Of 461 children, 424 (92%) completed follow-up. Most were under five (67%) with a median age of 3 years; 72.2% had AD onset before age two. Most caregivers were female (68.9%). After six months, clinical signs of AD, including dryness, erythema, excoriation, and lichenification, improved notably. Mild AD increased by 33.5%, while moderate and severe cases decreased by 17.5% and 16%, respectively. QoL significantly improved across all domains (p = 0.001). Baseline disease severity (β = 0.11), change in severity (ΔSCORAD) (β = 0.043), number of dependents (β = −0.71), and age at disease onset (β = 0.005) as significant predictors of QoL. Conclusions: AD significantly impairs QoL in Ethiopian children, with greater severity causing more disruption. Routine treatments with educational interventions significantly improve disease severity and QoL. Integrated clinical and psychosocial care approaches for pediatric AD are crucial in resource-limited settings. Full article

3D printing offers great potential for rapid and cost-effective fabrication of microfluidic lab-on-a-chip systems. Through a comparative approach, we implemented staggered herringbone mixer (SHM), Tesla mixer, and split and recombine mixer (SAR), along with a basic unperturbed channel into one chip and performed comparative mixing efficiency experiments. We also introduced a phaseguide-based, T-shaped stop structure at the Y-shaped inlets for bubble-free and parallel filling. The structures were analyzed with two poorly mixable dye solutions at flow rates ranging from 1 µL/min to 200 µL/min. The mixing efficiency was evaluated using optical gray value analysis and compared against diffusion-based mixing. The fluid-aligning phaseguides in the 3D-printed system were shown to work. Among the three different mixing structures tested, SHM exhibited the best mixing efficiency at all tested flow rates. Uniformly designed SHM structures contain a region of poor mixing between the two zones of turbulence. In a non-uniform design, fluid breakers were placed between two SHM units to redirect poorly mixed fluids to the edges, resulting in 100% mixing efficiency across all measured flow rates. These results, especially SHM with fluid breakers, support the development of cost-effective injection-molded lab-on-a-chip systems with improved mixing functionalities at close range instead of simple long-length meandric systems. Full article

Physicians performing cardiac angiography are exposed to scattered radiation originating from the patient, and visualizing scattered radiation sources could help optimize radiation protection strategies. In this study, an existing scattered radiation source visualization system comprising a high-sensitivity CMOS camera, thallium-activated cesium iodide scintillator, and pinhole collimator was extended to incorporate a depth camera and employed to visualize scattered radiation sources in three dimensions under conditions simulating clinical cardiac angiography. Scattered radiation source images were captured using a patient phantom under multiple irradiation directions of a biplane angiography system, and changes in the images and dose rate reaching the system were evaluated with and without radiation protection equipment and for various ceiling-mounted radiation shielding positions. The scattered radiation source was visualized on the patient phantom surface for a 5-s exposure in three-dimensional images and was observed around the X-ray tube in one direction. Radiation protection equipment reduced both the scattered radiation source intensity and dose rate. The greatest reduction occurred when the ceiling-mounted radiation shielding was positioned near the physician. Irradiation at caudal angles caused the highest increase in scattered radiation source intensity and dose rate. These findings suggest that this system can support the optimization of radiation protection practices and education. Full article

Background: Given the importance of early-life intervention in reducing future obesity, screening models that more accurately identify infants at risk are crucial. The aim of this study was to develop models based solely on growth parameters for better predicting childhood overweight than the current WHO growth chart risk prediction. Methods: A retrospective national cohort study was conducted among children born in Israel between August 2014 and June 2016, followed for at least 18 months. Machine learning models were generated to predict childhood overweight. Three models for 0–3, 3–6, and 6–12 months were generated. These models were compared with the current WHO growth chart predictions. The outcome was defined as overweight in early childhood, based on weight-for-length (or weight-for-height) ≥97th percentile, according to WHO standards, measured at 18–36 months of age. Results: Overall, 198,503 children were included, and 150,572, 146,584, and 149,628 infants were included in Models 1, 2, and 3, respectively, with an average target age of two years. The models demonstrated high predictive performance (AUC) for the 0–3 months’ model (0.76 [95% CI: 75 to 76.9%]), for the 3–6 months’ model (0.822 [95% CI: 81.3 to 83.0%]) and for 6–12-month-old infants (0.872 [95% CI: 86.6 to 87.8%]). The first two models better predict the risk of early childhood overweight than the current WHO growth chart prediction. Conclusions: These models are unique in that they are based on growth parameters, usually screened at early childhood worldwide, and can be implemented in any system collecting growth measurements of infants, providing better risk prediction than the current WHO growth charts. A web calculator is provided. Full article

Objective: This double-blind, parallel-group randomized controlled trial is the first to investigate the synergistic effects of interval resistance plus progressive aerobic training with fisetin supplementation on adipokines in obesity. Methods: Sixty sedentary men with obesity (BMI < 30 kg/m²) completed 12 weeks of thrice-weekly interval resistance training (eight exercises, 3 × 13 reps at 60% 1RM with 20% 1RM active rest), immediately followed by staged aerobic bouts (50–70% HRmax). Participants were randomized into the control-placebo (P), fisetin (F; 200 mg/day), training-placebo (TP), or training + fisetin (TF) groups. The primary outcomes were asprosin, MCP-1, and adiponectin; secondary outcomes included leptin and lipid profile. Data were analyzed via ANCOVA with Bonferroni post hoc tests. Results: Statistical analyses were conducted following the intention-to-treat (ITT) principle using an analysis of covariance (ANCOVA) model, which revealed extensive effects of the interventions on the participants’ anthropometric and biochemical indices. Regarding body composition, after adjusting for baseline values, a significant difference in mean body weight was observed between groups (F (3, 55) = 9.444, p < 0.001, ηp² = 0.340); Bonferroni post hoc tests confirmed that the training plus fisetin (TF), training-placebo (TP), and fisetin (F) groups all achieved significant weight loss compared to the placebo (P) group. Furthermore, body mass index (BMI) showed a significant inter-group difference (p = 0.021), with post hoc analysis revealing that only the TF group reached a statistically significant reduction compared to the placebo (p = 0.024; 95% CI [−3.760, −0.172]). In the assessment of biochemical and inflammatory variables, the interventions exerted a highly significant effect on asprosin (F (3, 55) = 36.047, p < 0.001; ηp² = 0.663) and MCP-1 (F (3, 55) = 29.570, p < 0.001; ηp² = 0.617). The findings indicated that the TF group experienced the most substantial reductions in both asprosin (−60.71%) and MCP-1 (−46.50%) levels. Regarding adipokines, significant increases in adiponectin levels were observed in the TP (29.38%) and TF (27.67%) groups (p < 0.05), whereas changes in leptin were statistically significant only in the TF group relative to the placebo (p = 0.049). The lipid profile results indicated a statistically significant difference in the TF group in improving all markers; this group achieved greater reduction compared to other groups, including reductions in LDL-C, triglycerides (TG), and total cholesterol (TC) (p < 0.001), while simultaneously showing a significant elevation in HDL-C. Post hoc analyses confirmed robust statistical differences in all lipid parameters for both the TF and TP groups compared to the placebo group (p < 0.05), whereas the placebo group experienced a deterioration in status characterized by a significant increase in LDL-C (p = 0.027) and a significant decline in HDL-C concentrations (p = 0.006). Conclusions: In conclusion, 12 weeks of combined interval resistance–aerobic training and fisetin supplementation significantly reduced pro-inflammatory adipokines and improved lipid profiles in obese men. These findings suggest that asprosin serves as a potential modulator in metabolic risk reduction; however, since direct mechanistic assays were not conducted, these implications remain hypothetical. Future research employing molecular readouts is warranted to confirm the underlying pathways involved. Full article