Kinases are critical intracellular signaling proteins. To better understand kinase-mediated signal transduction, a large-scale human–yeast genetic interaction screen was performed. Among 597 human kinase genes tested, 28 displayed strong toxici...
Background: There is a research gap between genetic predisposition, socioeconomic factors, and their interactions on thyroid tumorigenesis. Methods: Individual and genetic data were obtained from UK Biobank. Logistic regression models were used to ev...
The intensive farming of aquaculture species such as red tilapia (Oreochromis spp.) across diverse production systems can lead to changes in genetic parameters and responses of economically important traits in this species. This study represents the...
Maize (Zea mays L.) is widely cultivated worldwide and in Brazil under different production systems and technology levels. However, the interaction with different environments may hinder an accurate indication of maize genotypes. The effects of the g...
Sporadic Alzheimer’s disease (AD) is a polygenic neurodegenerative disorder. Single-nucleotide polymorphisms (SNPs) in multiple genes (e.g., CLU and ABCA7) have been associated with AD. However, none of them were characterized as causal variant...
Obesity is a multifactorial condition arising from the interaction between genetic and lifestyle factors. We aimed to assess the impact of lifestyle and genetic factors on obesity-related traits in 302 healthy Ghanaian adults. Dietary intake and phys...
Castanopsis hystrix, a timber resource from Southeast Asia, is characterized by rapid growth and high yield, but plantation quality and efficiency improvements are required. Twenty-year-old C. hystrix experimental forests in Yulin, Liuzhou, and Pingx...
Metabolic diseases result from interactions between genetic and lifestyle factors. Understanding the combined influences of single-nucleotide polymorphisms (SNPs) and lifestyle is crucial. This study employs genetic risk scores (GRS) to assess SNPs,...
Background/Objectives: Intervertebral disc degeneration (IDD) is a multifactorial spinal degenerative condition influenced by inherited susceptibility and environmental exposures. Genetic evidence from Chinese Han populations remains limited. This st...
The Super Cryogenic Dark Matter Search (SuperCDMS) experiment is used to search for Weakly Interacting Massive Particles (WIMPs)—candidates for dark matter particles. In this experiment, the WIMPs interact with nuclei in the detector; however,...
Background/Objectives: Management of bipolar disorder is marked by variability in lithium response, with responders constituting a distinct clinical subgroup. Although pharmacogenetic studies implicate polymorphisms in neuroplasticity-related genes (...
Genotype-by-environment interaction (G-by-E) is a common but potentially problematic phenomenon in plant breeding. In this study, we investigated the genotypic performance and two measures of plasticity on a phenotypic and genetic level by assessing...
Adipor1tm1Dgen and Mfrprd6 mutant mice share similar eye disease characteristics. Previously, studies established a functional relationship of ADIPOR1 and MFRP proteins in maintaining retinal lipidome homeostasis and visual function. However, the ind...
Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organis...
The genetic code conceals a ‘code within the codons’, which hints at biophysical interactions between amino acids and their cognate nucleotides. Yet, research over decades has failed to corroborate systematic biophysical interactions acro...
Signal transducer and activator of transcription 3 (STAT3) plays critical roles in tumorigenesis and malignant evolution and has been intensively studied as a therapeutic target for cancer. A number of STAT3 inhibitors have been evaluated for their a...
Nutritional genomics has exploded in the last decade, yielding insights—both nutrigenomic and nutrigenetic—into the physiology of dietary interactions and our genes. Among these are insights into the regulation of magnesium transport and homeostasis...
Wheat (Triticum aestivum L.) is a cornerstone of global nutrition yet yield-focused intensification has often overlooked the biological complexity of nutrient interactions and their implications for nutritional outcomes. This review synthesizes curre...
The human–computer interaction attribute of the interactive genetic algorithm (IGA) allows users to participate in the product design process for which the product needs to be evaluated, and requiring a large number of evaluations would lead to...
Genetic interactions (GIs), such as the synthetic lethal interaction, are promising therapeutic targets in precision medicine. However, despite extensive efforts to characterize GIs by large-scale perturbation screening, considerable false positives...
Paralleling the increasing trends of maternal obesity, gestational diabetes (GDM) has become a global health challenge with significant public health repercussions. In addition to short-term adverse outcomes, such as hypertensive pregnancy disorders...
Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms in microRNAs (mirSNPs) might...
The Ghanaian population is experiencing an upsurge in obesity and type 2 diabetes (T2D) due to rapid urbanization. Besides dietary factors, vitamin D-related genetic determinants have also been shown to contribute to the development of obesity and T2...
Background/Objectives: In Sri Lanka, where obesity is increasingly prevalent, evidence on gene–diet interactions involving macronutrient intake and composition remains limited. We therefore examined these interactions on obesity-related traits....
To create alternative complex patterns, a novel design method is introduced in this study based on the error back propagation (BP) neural network user cognitive surrogate model of an interactive genetic algorithm with individual fuzzy interval fitnes...
The transfer of mobile genetic elements (MGEs) has been known as a strategy adopted by organisms for survival and adaptation to the environment. The rhizosphere, where microbes and plants coexist, is a hotspot of MGE transfers. In this review, we dis...
Modulation of n-3 fatty acids on genetic susceptibility to type 2 diabetes (T2D) is still not clear. In a case-control study of 622 Chinese T2D patients and 293 healthy controls, a genetic risk score (GRS) was created based on nine T2D genetic varian...
Introduction: A genetic algorithm (GA)-based approach was designed to predict drug–drug interactions (DDIs) triggered by cytochrome P450 3A (CYP3A) inhibition or induction in horses. Methods: Area under the concentration-time curve ratios (AUCR...
Autophagy-mitophagy pathways are essential for regulating immune homeostasis. However, their contribution to population-level chronic low-grade systemic inflammation (SI) remains unclear. The objective was to investigate the association between varia...
Betula alnoides is a valuable timber species with wide ecological adaptability in Southeast Asia and southern China. There are more than 150,000 ha of B. alnoides plantations in China until now. However, heavy differentiation in growth and quality tr...
Tomato yellow leaf curl virus (TYLCV), tomato leaf curl New Delhi virus (ToLCNDV), and tomato chlorosis virus (ToCV) are emerging viruses that cause significant damage to tomato (Solanum lycopersicum). TYLCV and ToLCNDV are single-stranded DNA viruse...
29 September 2017
Obesity, which develops over time, is one of the leading causes of chronic diseases such as cardiovascular disease. However, hundreds of BMI (body mass index)-associated genetic loci identified through large-scale genome-wide association studies (GWA...
DNA methylation in insects is integral to cellular differentiation, development, gene regulation, genome integrity, and phenotypic plasticity. However, its evolutionary potential and involvement in facilitating rapid adaptations in insects are enigma...
A better knowledge of factors organizing crop genetic diversity in situ increases the efficiency of diversity analyses and conservation strategies, and requires collaboration between social and biological disciplines. Four areas of anthropology may c...
Asthma is a complex heterogeneous disease caused by gene–environment interactions. Although numerous genome-wide association studies have been conducted, these interactions have not been systemically investigated. We sought to identify genetic...
Energy intense nature of cement kiln demands optimal operation to minimize the energy requirement. Optimal control of cement kiln is achieved by proper tuning of the model predictive controller (MPC), which is addressed in this work. Genetic algorith...
Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of a...
15 October 2017
Background: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk facto...
Ciliopathies are genetic syndromes that link skeletal dysplasias to the dysfunction of primary cilia. Primary cilia are sensory organelles synthesized by intraflagellar transport (IFT)—A and B complexes, which traffic protein cargo along a micr...
There has been thorough research on the genotype by diet interaction and the extent of its impact on the genetic evaluation, using a partly replaced marine animal protein on the gilthead seabream. To do that, 8356 individuals were gathered from two b...
Folate-mediated one-carbon metabolism (FMOCM) is linked to DNA synthesis, methylation, and cell proliferation. Vitamin B6 (B6) is a cofactor, and genetic polymorphisms of related key enzymes, such as serine hydroxymethyltransferase (SHMT), methionine...
In response to the inadequate color-matching effectiveness and the difficulty of restoring color intentions in cultural heritage recreation, a Cultural Color Interactive Genetic Algorithm (Cultural Color IGA) is proposed, which combines a color netwo...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and expose patients to increased risk of hepatic and cardiovascular (CV) morbidity and mortality. Both environmental factors and genetic predispos...
Background: Cardiotoxic complications represent a major challenge in patients receiving anticancer therapy and may be influenced by interactions among demographic and genetic factors contributing to structural, functional, and electrophysiological my...
Selecting hyperparameters for training convolutional neural networks (CNNs) and determining the amount of training image data required for reliable generalization remain challenging and often time-consuming tasks, typically relying on manual trial-an...
Background/Objectives: Depression and anxiety disorders exhibit significant clinical heterogeneity, which complicates diagnosis and treatment. This study investigated whether tripartite interactions between biological sex, the serotonin transporter g...
Integration of archaeology, modern genetics, and ancient DNA holds promise for the reconstruction of the human past. We examine the advances in research on the indigenous peoples of Polynesia to determine: (1) what do archaeological and genetic data...
Seed development is under the control of complex and coordinated molecular networks required for the formation of its different components. The seed coat development largely determines final seed size and shape, in addition to playing a crucial role...
The assessment of 1000-kernel weight holds significant importance in determining maize grain yield, and elucidating its underlying genetic mechanisms is imperative for enhancing its overall performance. The material for the study consisted of 26 doub...
The genotype-by-environment interaction (G × E) might have crucial impacts on the performance and fitness of agricultural species, such as Pacific whiteleg shrimp (Litopenaeus vannamei). This study explores how enhancements in management practi...
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