Search Results (29,812)

Guanidines are structurally unique, highly basic, nitrogen-containing organic compounds with strong hydrogen-bonding ability and biological activity, providing valuable functionality in medicinal chemistry, organocatalysis, and materials science. Among modern strategies for assembling guanidine-containing molecules, cycloaddition reactions have emerged as powerful tools due to their efficiency, stereoselectivity, and ability to rapidly build molecular complexity. Recent innovations have expanded cycloaddition methodologies for generating guanidine functionalities, incorporating guanidine-containing substrates, and using guanidine-based catalysts. This review summarizes these advances and highlights the current trends in guanidine-related cycloaddition chemistry. Full article

Background: The aim of this study was to examine the relationship between anxiety levels, emotional intelligence, and stress coping strategies in individuals diagnosed with personality disorders. According to Lazarus and Folkman’s transactional model of stress, the appraisal of stressors and available psychological resources determines the selection of coping strategies—whether adaptive or maladaptive. Material and Methods: This observational case series study involved 30 individuals diagnosed with personality disorders (ICD-10 codes F60 and F61). Psychological assessments were conducted at two time points: upon admission to a day-care psychiatric unit and after three months of standard therapeutic intervention. The following standardized instruments were administered: the State-Trait Anxiety Inventory (STAI), the Emotional Intelligence Questionnaire (INTE), and the Mini-COPE Inventory for Coping with Stress. Results: Elevated levels of anxiety—particularly trait anxiety—were significantly associated with maladaptive coping strategies, including denial and self-blame. Conversely, higher emotional intelligence was positively correlated with the use of adaptive coping mechanisms, such as planning and proactive problem-solving. Conclusions: The findings support the hypothesis that both anxiety and emotional intelligence are significant predictors of stress coping styles in individuals with personality disorders. The results underscore the importance of considering these psychological variables in the design and implementation of therapeutic programs. Enhancing emotional intelligence may substantially improve treatment outcomes and overall psychological functioning in this clinical population. However, further studies with larger sample sizes are needed. Full article

While advanced imaging techniques and ordered porous materials like MOFs have gained prominence, gas sorption remains the indispensable tool for characterizing the multiscale heterogeneity of industrially important disordered solids, such as catalysts and shales. This review examines recent developments in gas sorption methodologies specifically tailored for rigid, disordered porous media. We discuss experimental advances, including the choice of adsorbate and the utility of the overcondensation method for probing macroporosity and ensuring saturation. Furthermore, we critically evaluate theoretical approaches for determining pore size distributions (PSDs), contrasting classical methods with Density Functional Theory (DFT) and Grand Canonical Monte Carlo (GCMC) simulations. Special emphasis is placed on the impact of pore-to-pore cooperative effects, such as advanced condensation, cavitation, and pore-blocking, on the interpretation of sorption isotherms. We highlight how complementary techniques, including integrated mercury porosimetry, NMR, and computerized X-ray tomography (CXT), are essential for deconvolving these complex network effects and validating void space descriptors. We conclude that, while “brute force” molecular simulations on image-based reconstructions are progressing, “minimalist” pore network models, which incorporate cooperative mechanisms, currently offer the most empirically adequate approach. Ultimately, gas sorption remains unique in its ability to statistically characterize void spaces from Angstroms to millimeters in a single experiment. Full article

Staphylococcus aureus, particularly its multidrug-resistant strains, poses a critical biological hazard throughout the global food supply chain, underscoring the need to transition from inert petroleum-based packaging to active, biodegradable alternatives. This review presents a comprehensive analysis of the structure function relationships and interfacial interaction mechanisms that govern polysaccharide-, protein-, and lipid-based films designed for the targeted inhibition of S. aureus. We critically evaluate the extent to which the intrinsic molecular features—such as the polycationic charge density of chitosan and the amphiphilic self-assembly of fatty acids—determine baseline antibacterial activity. A key contribution of this work is the elucidation of three synergistic pathways: physical barrier effects, chemical interference, and biological regulation. Furthermore, we discuss how composite systems, such as polysaccharide lipid hybrids and protein nanomaterial scaffolds, exploit charge complementarity and controlled-release kinetics to surpass the performance limitations of single-component materials. Finally, we address the critical trade-offs between mechanical integrity and antimicrobial efficacy, proposing a roadmap for intelligent, stimuli-responsive packaging that is capable of responding to microbial metabolic cues. Overall, this review provides a theoretical foundation for the rational design of high-performance biodegradable films to safeguard global food safety. Full article

The building sector has a significant environmental impact throughout the life cycle of a building. Reducing the environmental load of the building sector is essential for creating a sustainable society. Many current reports focus on carbon emission, while other environmental impacts remain insufficiently evaluated. Furthermore, buildings serve different functions depending on the region, and the types and quantities of primary materials used vary accordingly. Under these circumstances, little research has focused specifically on Japan. This study conducted a life cycle assessment (LCA) covering the life cycle of material inputs (structural and finishing materials) for 95 buildings in Japan. In addition to greenhouse gas emissions, multi-criteria analysis, including characterization and integration (characterization such as acidification, ozone layer destruction, and photochemical ozone; damage assessment; and integration using LIME2 and LIME3), was conducted. Based on analyses of numerous buildings, the objectives were to clarify trends in environmental impact emissions by building use, conduct an environmental impact analysis that could serve as a future benchmark, and discuss for reducing these environmental impacts. First, the analysis of trends such as maximum, median, and minimum values across six building types revealed that the environmental impact per square meter tended to be lower for production and logistics facilities and higher for offices, government buildings, schools, hospitals, hotels, and condominiums across many indicators. However, significant variations were observed between individual buildings within each category. These results can serve as a benchmark for the environmental impact of future buildings in Japan. Next, GHG emissions and integration (LIME2, LIME3) were quantitatively identified for materials with high emissions, and the factors were considered. Furthermore, processes with high environmental impacts associated with the material were analyzed and identified. Ready-mixed concrete, reinforcing bars, and steel frames showed high values across quantitative indicators, whereas wood and other materials varied by indicator. Finally, based on these findings, perspectives for reducing the environmental impact of key materials are proposed for each stakeholder group. Full article

(1) Background/Objectives: Gap formation contributes to the clinical failure of partial crowns. Therefore, it was analyzed at the interfaces between restoration, luting material, and tooth in partial crowns made of lithium disilicate ceramic (LS2) and nanohybrid composite (RBC) after thermomechanical loading (TCML) using optical coherence tomography (OCT). (2) Materials and Methods: Sixteen human mandibular molars were restored with CAD/CAM partial crowns made of LS2 (IPS e.max^® CAD) or RBC (Tetric^® CAD) using adhesive cementation (Variolink^® Esthetic DC). The restorations were imaged by OCT (1550 nm, 28 kHz) at t0 = 24 h, t1 = 90 days of water, t2 = after TCML with 480,000 loading cycles, and t3 = TCML with 1,200,000 loading cycles. Gap lengths (%) at interface 1 (partial crown-luting material) and interface 2 (luting material–enamel/dentin) were quantified. Groupwise and pairwise comparison of OCT parameters was conducted using the Mann–Whitney U, Friedman, and Conover–Iman tests with Bonferroni correction (α = 0.05). (3) Results: At interface 1, LS2 showed a larger median gap length than RBC (ceramic = 48.4%; composite = 5.2%, p < 0.01). At interface 2, the largest median gap length for LS2 was measured at the dentin (ceramic = 59.7%; composite = 52.5%), while for RBC, the enamel was more affected (ceramic = 26.2%; composite = 36.9%). (4) Conclusions: OCT enables reliable gap detection in partial crowns under functional loading and is therefore suitable for monitoring adhesive interface integrity. Under in vitro conditions, both materials demonstrated stable adhesive performance without debonding, while material-dependent differences in gap formation and distribution were observed. Full article

Polymer additive manufacturing (AM) has grown rapidly in the past decade, with material extrusion, vat photopolymerization, powder bed fusion and jetting now widely used for functional polymer parts. The mechanical performance of these parts depends strongly on process parameters such as layer height, build orientation, energy input and post-processing conditions, which motivate the development of predictive models for process–property relationships. Classical approaches based on Taguchi designs, ANOVA and response surface methodology have provided valuable insight, but the potential of modern machine learning (ML) techniques is not yet fully exploited. This review surveys recent work on ML-based prediction of mechanical properties of polymer AM parts using process parameters as inputs. Across the literature, well-tuned artificial neural networks, tree-based ensembles and support vector regression typically achieve prediction errors below about 5–10% for strength and modulus, showing that data-driven surrogates can substantially reduce experimental trial-and-error in process optimization. Ongoing challenges include small datasets, missing standardized error metrics, and limited coverage of non-quasi-static phenomena like fatigue, impact, and environmental degradation. Full article

Flatland metasurfaces provide a fundamentally distinct approach to optical gas sensing by confining light–matter interaction to planar, subwavelength interfaces, where resonant energy storage and near-field enhancement replace extended optical path lengths. This review presents a physics-driven perspective on metasurface-enabled gas sensing, focusing on how gaseous analytes perturb the complex eigenmodes of engineered planar resonators. Diverse sensing modalities, including enhanced molecular absorption, refractive index-induced resonance shifts, loss modulation, polarization conversion, and chemo-optical transduction, are unified within a common perturbative framework that links sensitivity to mode confinement, quality factor, and analyte overlap. The analysis highlights fundamental trade-offs imposed by material dispersion, intrinsic loss, and radiation balance across plasmonic, dielectric, polaritonic, and hybrid metasurface platforms operating from the visible to the terahertz regime. Attention is given to the limits of chemical selectivity in flatland architectures and to the role of functional materials, multimodal transduction, and computational inference in addressing these constraints. System-level considerations, including thermal stability, fabrication tolerance, and integration with detectors and electronics, are identified as critical determinants of real-world performance. By consolidating disparate approaches within a unified flatland framework, this review provides physical insight and design guidance for the development of compact, integrable, and application-specific optical gas sensing systems. Full article

Reciprocating compressor air volume control systems have been extensively investigated, with a primary objective of reducing energy consumption and associated carbon footprints. As a multi-actuator system, failures in this energy-efficient configuration can trigger severe operational disruptions with cascading consequences. To address this, we initially constructed numerical models of the multi-actuator energy-efficient system to decode the variational patterns of compressor dynamic pressure pulsations and connecting-rod small-end bush tribological behaviors under partial actuator fault conditions, thereby establishing foundational data for fault degradation stratification. Building upon this, we propose a Prognostics and Health Management (PHM) algorithm using fault degradation analysis, thereby materializing self-recovery functionality in response to various fault conditions. Experimental validation demonstrates that the self-recovery algorithm successfully contained deterioration propagation through proactive intervention. The system achieved autonomous healing within 8 s (mild faults) and 13 s (moderate faults), constraining discharge fluctuations and vibration amplitude within allowable thresholds. This study establishes a solution framework for preserving multi-actuator energy-efficient systems’ health, accuracy, and economy. Full article

Climate-smart forestry (CSF) is a comprehensive approach that aims to sustainably enhance wood productivity (production), improve forest resilience and adaptation, sequester carbon (mitigation), and support broader development goals. This strategy is profoundly linked with Forest Genetic Resources (FGR), which are crucial for the adaptive capacity and long-term sustainability of forest ecosystems in the face of the escalating climatic changes. Climate change presents significant risks, including increased air temperatures, altered precipitation regimes, and a rise in extreme weather events, leading to tree mortality, shifts in vegetation distribution, and a potential loss of critical forest functions and services, such as carbon sequestration capacity. While forests have inherent resilience, the rapidity and magnitude of projected changes may exceed their natural adaptive capacity, potentially resulting in local extinction and degradation of ecosystems. This review explores various facets of the interplay between CSF and FGR, emphasizing their role in sustainable forest management. Key areas of focus include: (1) Genetic Diversity, (2) Genotype Selection and Breeding, (3) Modern Breeding Techniques, (4) Molecular Breeding, (5) Genomic Prediction (GP), (6) Breeding Programs, (7) Silvicultural Practices, (8) Adaptation Mechanisms, (9) Phenotypic Plasticity, (10) Migration, particularly Assisted Gene Flow (AGF) and (11) Reproductive Material Management. Ultimately, the study highlights the crucial role of FGR in the resilience of forest ecosystems and proposes future actions for their integration into CSF strategies, including in situ and ex situ conservation, assisted migration, advanced research and development, community involvement, and supportive policy frameworks, all vital for the long-term sustainability and vitality of forest ecosystems in a changing climate. Full article

Betaine, a simple natural zwitterion, is currently attracting widespread attention. Although historically labeled as an osmoregulator in agriculture and a methyl donor in animal nutrition, the molecule is now being repositioned at the forefront of green chemistry and materials science due to its unique physicochemical structure. This review critically explores the expanding horizon of betaine applications, bridging the gap between its established biological functions and its emerging roles in recently reported technologies, such as deep eutectic solvents (DESs), cocrystal engineering, and sustainable polymer synthesis. Beyond summarizing its versatile functionality across biomedicine, food science, and industrial formulations, we provide a comprehensive bibliometric analysis to map the evolution of research trends, identifying a clear focus toward industrial ecology and advanced materials. By synthesizing current advancements and discussing potential future directions, this work highlights betaine not merely as a supplement, but as a versatile molecular component with potential applications in sustainable materials and chemical engineering processes. Full article

Background/Objectives: Franz Tappeiner (1816–1902) is often celebrated as a pioneer of alpine medicine and the founder of Tappeiner Promenade in Meran (South Tyrol, Italy). However, his legacy extends far beyond the scenic infrastructure, encompassing a comprehensive vision of physical activity as a public health intervention. His multidisciplinary practice anticipated the principles of contemporary rehabilitation, preventive medicine, and climate-sensitive public health. Methods: This historical public health analysis, combining biographical, contextual, and material–spatial approaches, reinterprets Tappeiner’s writings, institutional engagements, and civic projects through the lens of modern public health frameworks. Drawing on primary materials (e.g., published articles, autobiographical fragments, and commemorative texts) and recent evidence from rehabilitation and environmental health research, these contributions were contextualized. Results: Tappeiner’s early focus on infectious disease prevention (e.g., cholera and tuberculosis) transitioned into a strategic emphasis on recovery and behavioral therapy through environmental design. The walking therapy model of Max Joseph Oertel, locally realized in the Tappeiner Promenade, prefigured modern concepts such as structured green rehabilitation, walkability, and urban-health citizenship. His systematic integration of graded walking into civic infrastructure represents one of the earliest documented examples of embedding physical activity promotion at the population level. He contributed substantial personal funds to the path’s construction, embedding therapeutic gradients, curating vegetation, and promoting inclusive design to support convalescence. Contemporary research supports the intuition that green, low- to moderate-intensity walking improves cardiometabolic health, psychological well-being, and functional capacity. Moreover, his integrative ethos, merging clinical medicine, civic ethics, and spatial intervention, parallels contemporary eco-social models of public health. Conclusions: Franz Tappeiner’s career exemplifies a still-relevant model of physician leadership that is empirically grounded, socially accountable, and ecologically attuned, with physical activity promotion embedded as a central element of his public health vision. His work invites reflection on how medical professionals can shape not only individual care but also urban environments and collective health futures. Full article

The incorporation of carbon nanotubes (CNT) into cementitious composites has shown strong potential for enhancing mechanical performance. However, conventional dispersion methods, such as ultrasonication and chemical functionalization, are costly, complex, and difficult to scale for construction applications. This study introduces an alternative approach based on the in situ synthesis of CNT on active silica grains, which enables their direct incorporation into mortar formulations. The material was produced via chemical vapor deposition and characterized by scanning electron microscopy, thermogravimetric analysis, energy-dispersive spectroscopy, and Fourier-transform infrared spectroscopy. The resulting nanostructured active silica (NAS) exhibited high carbon content (80.7%) and a 1350% yield, confirming efficient nanotubular deposition. Residual oxygen (9.12%), Mg (0.75%), and Al (0.17%) indicated partial retention of catalytic species, while Fe–Co promoters with Mg–Al modifiers enabled a catalytically active surface favorable to CNT growth. Mortars incorporating NAS restored the flexural strength losses associated with cement replacement by silica, achieving values comparable to the reference mixture and outperforming the silica-only sample; compressive strength increased by ~16.5%. These results demonstrate that NAS promotes effective CNT dispersion at the composite scale without additional dispersion techniques, reduces process complexity, and adds value to commercial silica, providing a scalable route for developing nanostructured cementitious composites for construction applications. Full article

Biochar obtained from digestate is a promising material in the context of digestate management. However, it is important to note that the properties of the resulting material are largely dependent on the parameters of the pyrolysis process, with temperature being a particularly significant factor. The objective of this study was to evaluate the impacts of the digestate pyrolysis temperature on the chemical structure, thermal stability, and thermal decomposition characteristics of biochar produced at temperatures of 400, 500, 600, and 800 °C in an inert nitrogen atmosphere. Material characterization was performed using a range of analytical techniques, including elemental analysis, FTIR spectroscopy, thermogravimetric analysis (TGA/DTG), and coupled TGA–FTIR analysis, in order to identify volatile products released during the heating process. The results demonstrated that elevating the pyrolysis temperature results in progressive carbonization and aromatization of the carbon structure. Concurrently, functional groups containing oxygen and hydrogen were eliminated, as evidenced by declines in the H/C and O/C atomic ratios. FTIR analysis confirmed the disappearance of aliphatic and hydroxyl bands, as well as the dominance of aromatic structures and mineral components in biochar subjected to high-temperature treatment. The TGA results demonstrated an enhancement in thermal stability with increasing pyrolysis temperature. Concurrently, the TGA–FTIR analysis revealed a substantial decline in the emission of volatile decomposition products from biochar obtained at temperatures ≥600 °C. Overall, the pyrolysis temperature of digestate determines the utilization potential of the resulting biochar; in particular, low-temperature biochar can be used as a soil amendment and methane fermentation stimulant, while high-temperature biochar can be used for contaminant immobilization in soil and long-term carbon sequestration. Full article