Search Results (42)

This paper proposes a robust voltage control strategy for grid-forming (GFM) inverters in distribution networks to achieve power support and voltage optimization. Specifically, the GFM control approach primarily consists of a power synchronization loop, a voltage feedforward loop, and a current control loop. A voltage feedforward control circuit is presented to achieve error-free tracking of voltage amplitude and phase. In particular, the current gain is designed to replace voltage feedback for improving the current response and simplifying the control structure. Additionally, in order to optimize voltage and improve the power quality at the terminal of the distribution network, an optimization model for distribution transformers is established with the goal of the maximum qualified rate of the load-side voltage and minimum switching times of transformer tap changers. An enhanced whale optimization algorithm (EWOA) is designed to complete the algorithm solution, thereby achieving the optimal system configuration, where an improved attenuation factor and position updating mechanism is proposed to enhance the EWOA’s global optimization capability. The simulation results demonstrate the validity and feasibility of the proposed strategy. Full article

The permanent magnet synchronous motor (PMSM) is a critical device that converts kinetic energy into mechanical energy. However, it faces issues such as nonlinearity, time-varying uncertainties, and external disturbances, which may degrade the system control performance. To address these challenges, this paper proposes a prescribed performance model-free adaptive fast integral terminal sliding mode control (PP-MFA-FITSMC) method. This approach replaces conventional techniques such as parameter identification, function approximation, and model reduction, offering advantages such as quantitative constraints on the PMSM tracking error, reduced chattering, strong disturbance rejection, and ease of engineering implementation. The method establishes a compact dynamic linearized data model for the PMSM system. Then, it uses a discrete small-gain extended state observer to estimate the composite disturbances in the PMSM online, effectively compensating for their adverse effects. Meanwhile, an improved prescribed performance function and error transformation function are designed, and a fast integral terminal sliding surface is constructed along with a discrete approach law that adaptively adjusts the switching gain. This ensures finite-time convergence of the control system, forming a model-free, low-complexity, high-performance control approach. Finally, response surface methodology is applied to conduct a sensitivity analysis of the controller’s critical parameters. Finally, controller parameter sensitivity experiments and comparative experiments were conducted. In the parameter sensitivity experiments, the response surface methodology was employed to design the tests, revealing the impact of individual parameters and parameter interactions on system performance. In the comparative experiments, under various operating conditions, the proposed strategy consistently constrained the tracking error within ±0.0028 rad, demonstrating superior robustness compared to other control methods. Full article

Calcium (Ca²⁺) signaling is a fundamental regulatory mechanism controlling essential processes in the endothelium, vascular smooth muscle cells (VSMCs), and the extracellular matrix (ECM), including maintaining the endothelial barrier, modulation of vascular tone, and vascular remodeling. Cytosolic free Ca²⁺ concentration is tightly regulated by a balance between Ca²⁺ mobilization mechanisms, including Ca²⁺ release from the intracellular stores in the sarcoplasmic/endoplasmic reticulum and Ca²⁺ entry via voltage-dependent, transient-receptor potential, and store-operated Ca²⁺ channels, and Ca²⁺ elimination pathways including Ca²⁺ extrusion by the plasma membrane Ca²⁺-ATPase and Na⁺/Ca²⁺ exchanger and Ca²⁺ re-uptake by the sarco(endo)plasmic reticulum Ca²⁺-ATPase and the mitochondria. Some cell membranes/organelles are multifunctional and have both Ca²⁺ mobilization and Ca²⁺ removal pathways. Also, the individual Ca²⁺ handling pathways could be integrated to function in a regenerative, capacitative, cooperative, bidirectional, or reciprocal feed-forward or feed-back manner. Disruption of these pathways causes dysregulation of the Ca²⁺ signaling dynamics and leads to pathological cardiovascular conditions such as hypertension, coronary artery disease, atherosclerosis, and vascular calcification. In the endothelium, dysregulated Ca²⁺ signaling impairs nitric oxide production, reduces vasodilatory capacity, and increases vascular permeability. In VSMCs, Ca²⁺-dependent phosphorylation of the myosin light chain and Ca²⁺ sensitization by protein kinase-C (PKC) and Rho-kinase (ROCK) increase vascular tone and could lead to increased blood pressure and hypertension. Ca²⁺ activation of matrix metalloproteinases causes collagen/elastin imbalance and promotes vascular remodeling. Ca²⁺-dependent immune cell activation, leukocyte infiltration, and cholesterol accumulation by macrophages promote foam cell formation and atherosclerotic plaque progression. Chronic increases in VSMCs Ca²⁺ promote phenotypic switching to mesenchymal cells and osteogenic transformation and thereby accelerate vascular calcification and plaque instability. Emerging therapeutic strategies targeting these Ca²⁺-dependent mechanisms, including Ca²⁺ channel blockers and PKC and ROCK inhibitors, hold promise for restoring Ca²⁺ homeostasis and mitigating vascular disease progression. Full article

Background: The use of cyclin-dependent kinase 4/6 inhibitors (CDK 4/6i) with endocrine therapy (ET) is a first-line standard treatment for hormone receptor-positive (ER+) Human Epidermal Growth factor Receptor-2-negative (HER2-) advanced breast cancer. The data supporting incorporation of CDK 4/6i + ET beyond progression are variable. Here, we report a pooled analysis of this strategy. Methods: A systematic review identified reports of both observational and clinical studies, which evaluated the continuation of CDK4/6i beyond progression. The mean overall response rate (ORR) and progression-free survival (PFS) weighted by the study sample size were calculated. Meta-regression comprising linear regression weighted by the sample size (mixed effects) was performed to explore the association between disease and treatment-related factors and the benefit from continuing CDK4/6i. Quantitative significance was assessed using the Burnand criteria. Results: Thirteen studies comprising 1530 patients were included. The median age was 58 years, 50.8% had visceral metastases, and 48% had ESR1 mutations; the median lines of prior therapies were 1 (range 1–5), and 96.3% received palbociclib as the initial CDK4/6i. Eight studies tested a CDK4/6i switch as the intervention. The median PFS was 5.3 months, and the ORR was 14%. In randomized studies, statistically significant differences were observed between CDK4/6i continuation and control, although it is uncertain whether the magnitude of the effect is clinically meaningful. Increasing age, lack of prior chemotherapy, no visceral metastasis or ESR1 mutations, and a switch to a non-palbociclib CDK4/6i were associated with better outcomes. Conclusion: Continuing a CDK 4/6i + ET beyond progression yields modest benefits. Switching CDK4/6i likely results in improved ORR and PFS. Continuing palbociclib beyond progression is likely ineffectual. Full article

The inconsistency of individual lithium-ion batteries causes the voltage imbalance of the batteries. An effective voltage-balancing circuit is essential to improve the inconsistency of series-connected batteries. This paper presents an isolated resonant voltage-balancing circuit for series-connected lithium-ion batteries based on a multi-port transformer. This circuit utilizes the multi-port transformer to enable free energy flow among the batteries. Without any direct transmission path between the capacitor and the battery string, it achieves full isolation between them. The resonant circuit is adopted to realize the soft-switching operation. Compared with other active balancing circuits, the proposed circuit requires only half a winding and one transistor per individual battery. Consequently, the proposed circuit enhances power density and further improves efficiency and reliability. Additionally, a fixed-group-number control strategy is introduced to enhance the circuit’s equalization voltage capabilities. Finally, a prototype of the voltage-balancing circuit for 24 series-connected lithium-ion batteries is established to verify the effectiveness and feasibility of the proposed circuit. Full article

Switched reluctance motors (SRMs) offer several advantages, including a magnet- and winding-free rotor, high mechanical strength, and exceptional output efficiency. However, the doubly salient pole structure and high-frequency switching power supply result in significant torque ripple and electromagnetic noise, which limit the application in the field of new energy vehicles. To address these issues, this paper proposes a direct instantaneous torque control (DITC) strategy based on an optimal switching angle torque sharing function (TSF). Firstly, an improved cosine TSF is designed to reasonably distribute the total reference torque among the phases, stabilizing the synthesized torque of SRM during the commutation interval. Subsequently, an improved artificial bee colony (ABC) algorithm is used to obtain the optimal switching angle data at various speeds, integrating these data into the torque distribution module to derive the optimal switching angle model. Finally, the effectiveness of the proposed control strategy is validated through simulations of an 8/6-pole SRM. Simulation results demonstrate that the proposed control strategy effectively suppresses torque ripple during commutation and reduces the peak current at the beginning of phase commutation. Full article

Nosema is a diverse fungal genus of unicellular, obligate symbionts infecting various arthropods. We performed comparative genomic analyses of seven Nosema species that infect bees, wasps, moths, butterflies, and amphipods. As intracellular parasites, these species exhibit significant genome reduction, retaining only about half of the genes found in free-living yeast genomes. Notably, genes related to oxidative phosphorylation are entirely absent (p < 0.001), and those associated with endocytosis are significantly diminished compared to other pathways (p < 0.05). All seven Nosema genomes display significantly lower G-C content compared to their microsporidian outgroup. Species-specific 5~12 bp motifs were identified immediately upstream of start codons for coding genes in all species (p ≤ 1.6 × 10⁻⁷²). Our RNA-seq data from Nosema muscidifuracis showed that this motif is enriched in highly expressed genes but depleted in lowly expressed ones (p < 0.05), suggesting it functions as a cis-regulatory element in gene expression. We also discovered diverse telomeric repeats within the genus. Phylogenomic analyses revealed two major Nosema clades and incongruency between the Nosema species tree and their hosts’ phylogeny, indicating potential host switch events (100% bootstrap values). This study advances the understanding of genomic architecture, gene regulation, and evolution of Nosema, offering valuable insights for developing strategies to control these microbial pathogens. Full article

The stability of hydrogen fuel cell system power generation is affected by key variables such as oxygen excess ratio (OER), electric stack temperature, and cathode–anode differential pressure. To increase the fuel cell’s stability, a sliding mode integral separation proportional–integral–derivative (SMC−IS−PID) control strategy was proposed by combining the four−segment integral separation PID (IS−PID) control with the switching control in the sliding mode control (SMC). The control mode is selected through the system variable error and the current variable value; if there are significant systematic variable errors, the switching control in the SMC adopts the four−segment integral separation PID control, which determines the values of the segmentation thresholds and controls the integral weights to reduce the amount of overshoot. When the error of the system variables is small, the switching control in the SMC adopts the improved convergence law control, which introduces the hyperbolic tangent exponential power term, the nonlinear function term, and the saturation function term to improve the convergence law and decrease the control’s convergence time. Experimentally verifying the effectiveness of the control strategy above, the results show that for the OER, the SMC−IS−PID overshoots 0 and realizes no overshooting with a regulation time of 5.019 s. For the temperature of the stack, the SMC−IS−PID overshoots only 0.134% with a regulation time of 40.521 s. For the pressure of the stack, the SMC−IS−PID realizes the system is basically free of oscillation. Full article

Since the development of recombinant DNA technologies, the need to establish biosafety and biosecurity measures to control genetically modified organisms has been clear. Auxotrophies, or conditional suicide switches, have been used as firewalls to avoid horizontal or vertical gene transfer, but their efficacy has important limitations. The use of xenobiological systems has been proposed as the ultimate biosafety tool to circumvent biosafety problems in genetically modified organisms. Xenobiology is a subfield of Synthetic Biology that aims to construct orthogonal biological systems based on alternative biochemistries. Establishing true orthogonality in cell-based or cell-free systems promises to improve and assure that we can progress in synthetic biology safely. Although a wide array of strategies for orthogonal genetic systems have been tested, the construction of a host harboring fully orthogonal genetic system, with all parts operating in an orchestrated, integrated, and controlled manner, still poses an extraordinary challenge for researchers. In this study, we have performed a thorough review of the current literature to present the main advances in the use of xenobiology as a strategy for biocontainment, expanding on the opportunities and challenges of this field of research. Full article

Modular multilevel converters (MMCs) have gained widespread adoption in high-voltage direct current (HVDC) transmission due to their high voltage levels, low harmonic content, and high scalability. However, conventional control methods such as finite control set model predictive control (FCS-MPC) suffer from a heavy computational burden and sensitivity to system parameter variations, limiting the performance of MMCs. This paper proposes a data-driven approach based on model-free adaptive control with an event-triggered mechanism that demonstrates superior robustness against parameter mismatches and enhanced dynamic performance in response to sudden output changes. Moreover, the introduction of the event-triggered mechanism effectively reduces redundant operations, decreasing the computational burden and switching losses. Finally, the proposed strategy is validated through a MATLAB/Simulink simulation model. Full article

Background: This research was designed to carry out a meta-analysis in order to evaluate the dissimilarities in the stability of alveolar bone round dental implants and implant failure between platform switching (PS) and platform mating (PM). Methods: The investigation utilized a comprehensive search strategy that incorporated controlled vocabulary (MeSH) and free-text terms. This search was performed by two reviewers to identify published systematic reviews. Three major electronic databases, including Medline via PubMed, the Cochrane database, and Embase, were searched up to November 2023. Results: Initially, 466 articles were identified, but only twelve studies met the criteria for inclusion in the meta-analysis. The results showed that the pooled mean difference for reducing marginal bone loss (MBL) was −0.60 (95% confidence interval (CI), −0.91 to −0.28; p < 0.01). A sensitivity analysis was conducted by excluding a single study, which yielded a result of −0.46 (95% CI, −0.66 to −0.25; p < 0.01). The test for overall effect was significant (p < 0.01), and it revealed that there were significant differences between subgroups. However, the meta-analysis on implant failure did not show a significant difference between PS and PM implants. Conclusions: In conclusion, the study found that PS implants are more effective in reducing MBL compared to PM implants. Nevertheless, no significant difference was observed in the long-term effectiveness of reducing MBL and implant failure rate. Full article

This paper introduces an innovative method for load frequency control (LFC) in multi-area interconnected power systems vulnerable to denial-of-service (DoS) attacks. The system is modeled as a switching system with two subsystems, and an adaptive control algorithm is developed. Initially, a dynamic linear data model is used to model each subsystem. Next, a model-free adaptive control strategy is introduced to maintain frequency stability in the multi-area interconnected power system, even during DoS attacks. A rigorous stability analysis of the power system is performed, and the effectiveness of the proposed approach is demonstrated by applying it to a three-area interconnected power system. Full article

This paper demonstrates the utilization of Pontryagin Neural Networks (PoNNs) to acquire control strategies for achieving fuel-optimal trajectories. PoNNs, a subtype of Physics-Informed Neural Networks (PINNs), are tailored for solving optimal control problems through indirect methods. Specifically, PoNNs learn to solve the Two-Point Boundary Value Problem derived from the application of the Pontryagin Minimum Principle to the problem’s Hamiltonian. Within PoNNs, the Extreme Theory of Functional Connections (X-TFC) is leveraged to approximate states and costates using constrained expressions (CEs). These CEs comprise a free function, modeled by a shallow neural network trained via Extreme Learning Machine, and a functional component that consistently satisfies boundary conditions analytically. Addressing discontinuous control, a smoothing technique is employed, substituting the sign function with a hyperbolic tangent function and implementing a continuation procedure on the smoothing parameter. The proposed methodology is applied to scenarios involving fuel-optimal Earth−Mars interplanetary transfers and Mars landing trajectories. Remarkably, PoNNs exhibit convergence to solutions even with randomly initialized parameters, determining the number and timing of control switches without prior information. Additionally, an analytical approximation of the solution allows for optimal control computation at unencountered points during training. Comparative analysis reveals the efficacy of the proposed approach, which rivals state-of-the-art methods such as the shooting technique and the adaptive Gaussian quadrature collocation method. Full article

A fundamental problem at the intersection of process control and operations is the design of detection schemes monitoring a process for cyberattacks using operational data. Multiplicative false data injection (FDI) attacks modify operational data with a multiplicative factor and could be designed to be detection evading without in-depth process knowledge. In a prior work, we presented a control mode switching strategy that enhances the detection of multiplicative FDI attacks in processes operating at steady state (when process states evolve within a small neighborhood of the steady state). Control mode switching on the attack-free process at steady-state may induce transients and generate false alarms in the detection scheme. To minimize false alarms, we subsequently developed a control mode switch-scheduling condition for processes with an invertible output matrix. In the current work, we utilize a reachable set-based detection scheme and use randomized control mode switches to augment attack detection capabilities. The detection scheme eliminates potential false alarms occurring from control mode switching, even for processes with a non-invertible output matrix, while the randomized switching helps bolster the confidentiality of the switching schedule, preventing the design of a detection-evading “smart” attack. We present two simulation examples to illustrate attack detection without false alarms, and the merits of randomized switching (compared with scheduled switching) for the detection of a smart attack. Full article

Background: While the outcomes of chronic phase chronic myeloid leukemia (CP-CML) patients aged over 65 years have been extensively evaluated in real-life experiences, limited data exist for the very elderly population (i.e., aged ≥ 75 years), especially for next-generation tyrosine kinase inhibitors (TKIs). In this retrospective study, we sought to evaluate the safety and efficacy of TKIs in this particular setting of patients. Methods: We conducted a retrospective analysis of a multicenter cohort of 123 newly diagnosed CP-CML very elderly patients. Results: The median age at diagnosis was 80 years (range: 75–96). In the first line, 86.1% of patients received imatinib, 7.1% dasatinib, 5.6% nilotinib, and 0.81% received bosutinib. A total of 31 patients (25.2%) switched to second-line therapy, nine patients to a third line, and one patient to a fourth line of therapy. Resistance to treatment was the primary reason for switching therapy in both the first (64.5%) and second lines (77.7%). At diagnosis, reduced doses were administered in 36.5% of patients, in 61.2% in the second line, and in all patients in subsequent lines of therapy. In the first-line setting, 71.9% of patients achieved an early molecular response (EMR, i.e., 3-month BCR::ABL1^IS < 10%); at 6, 12, and 24 months, MR3 was reached by 35.7%, 55.7%, and 75.0% of patients, respectively, with 16.6%, 35.7%, and 51.7% achieving a deep molecular response (DMR) at the same time points. Treatment-free remission (TFR) was successfully attempted in 11 patients. During the follow-up period, adverse events (AEs) were observed in 78.8% of patients, including 22 cases of cardiovascular AEs. Toxicity grade ≥ 3 was more commonly observed in patients treated with standard doses of TKIs compared to reduced doses (p = 0.033). Overall, the median follow-up was 46.62 months (range: 1.8–206.2), and 43 patients died due to non-CML-related causes. Three patients died due to disease progression to advanced (n = 1) and blastic (n = 2) phases. The 5-year overall survival (OS) for the entire cohort was 71.9% (95% CI: 0.63–0.81), with no significant difference between the patients treated with standard doses of TKIs compared to those treated with reduced doses (p = 0.35). Conclusions: TKIs appear to be safe and effective even in very elderly CML patients, and dose optimization strategies yield satisfactory molecular responses for adequate disease control with an improved safety profile. Full article