Search Results (39)

Two-way channel irrigation pumping stations are widely used along rivers for irrigation and drainage. Due to fluctuating internal and external water levels, these stations often operate under ultra-low or near-zero head conditions, leading to poor hydraulic performance. This study employs computational fluid dynamics (CFD) to investigate such systems’ pressure fluctuation and chaotic dynamic characteristics. A validated 3D model was developed, and the wavelet transform was used to perform time–frequency analysis of pressure signals. Phase space reconstruction and the Grassberger–Procaccia (G–P) algorithm were applied to evaluate chaotic behavior using the maximum Lyapunov exponent and correlation dimension. Results show that low frequencies dominate pressure fluctuations at the impeller inlet and guide vane outlet, while high-frequency components increase significantly at the intake bell mouth and outlet channel. The maximum Lyapunov exponent in the impeller and guide vane regions reaches 0.0078, indicating strong chaotic behavior, while negative values in the intake and outlet regions suggest weak or no chaos. This integrated method provides quantitative insights into the unsteady flow mechanisms, supporting improved stability and efficiency in ultra-low-head pumping systems. Full article

This study investigated the effects of Clostridium butyricum (C. butyricum) supplementation on the bacterial community composition and fermentation characteristics of the digestive system, assessed blood antioxidant capacity, and evaluated growth performance and digestibility in pre-weaning Angus calves. Sixteen male Angus calves were randomly divided into two groups (n = 8). The control group was fed a basal diet, while the other group was supplemented with 2 × 10⁷ colony-forming unit/d C. butyricum in the basal diet. After 8 weeks of feeding, body growth and nutrient intake were measured. Rumen fluid samples, blood samples, and fecal samples were collected and analyzed. Fecal scores were recorded daily, and the frequency of diarrhea treatments was documented. The results showed C. butyricum supplementation improved the digestibility of neutral detergent fiber, crude protein, and ether extract in calves, as well as the growth hormone content in the blood. Furthermore, supplementation elevated isovaleric acid concentrations in the rumen, modulated the microbiome, and increased pre-weaning body weight and average daily gain of calves. Meanwhile, C. butyricum supplementation reduced myeloperoxidase and superoxide dismutase levels while increasing total antioxidant capacity in the blood, alleviating oxidative stress, and enhancing the antioxidant capacity of the body. Intestinal health was also improved, as evidenced by an increase in butyrate content, a reduction in enterotoxigenic Escherichia coli, lower fecal scores, and a decreased need for diarrhea treatments. In summary, dietary C. butyricum supplementation may support digestive system development, enhance antioxidant capacity, and improve growth performance and health status in pre-weaning Angus calves. Full article

Human milk (HM) is a complex biological fluid that plays a significant role in infant health, influenced by maternal dietary habits and body composition. This study aimed to explore how maternal diet and nutritional status affect the microbial composition of HM. In this pilot study, 15 mothers were recruited from a maternity ward and assessed for dietary habits through a semi-structured food frequency questionnaire and a 3-day dietary record. Maternal body composition was evaluated using bioelectrical impedance analysis. HM samples were collected for microbiota analysis, focusing on the diversity and composition of bacterial communities via 16S rRNA sequencing. The study identified that maternal nutrient intake significantly correlated with the composition of HM microbiota. Specifically, Firmicutes abundance showed positive correlations with animal protein (τ = 0.39; p = 0.043), total carbohydrates (τ = 0.39; p = 0.043), and vitamin A (τ = 0.429; p = 0.026). Bacteroidota was positively correlated with retinol (τ = 0.39; p = 0.043). Higher consumption of dietary fiber (>24 g/day) did not yield significant differences in bacterial composition compared to lower intake (<24 g/day) (p = 0.8977). Additionally, no significant differences were found in overall bacterial abundance across different maternal characteristics such as age, mode of delivery, or breastfeeding type. This study underscores the importance of maternal diet in shaping the HM microbiota, which may have implications for infant health. Dietary modifications during lactation could be a strategic approach to promote beneficial microbial colonization in HM. Further research is warranted to confirm these findings and explore the underlying mechanisms. Full article

Background/Objectives: Sarcopenia, characterized by the loss of muscle mass and strength, is prevalent in older persons and affects their quality of life. Nutritional intervention and physical activity play a key role in its prevention and treatment. This study aims to investigate the relationship between food consumption frequency as assessed through the Mini Nutritional Assessment (MNA) and probable sarcopenia, evaluated by grip strength, in Chilean older persons aged 65 or older. Methods: A correlational, cross-sectional study with a non-probabilistic sample of 155 older persons aged 65 or older was undertaken. Food consumption frequency was assessed using the MNA, and muscle strength was measured using a handgrip dynamometer. The authors analyzed the relationship between food consumption frequency, as assessed by the MNA, and the protein intake index with muscle strength. Results: Participants who consumed less than two servings of fruits and vegetables per day were 4.28 times more likely to have low muscle strength compared to those who consumed two or more servings per day (OR = 4.28; 95% CI: 1.59–11.45). No significant associations were found with the consumption of dairy products, legumes, meat, fish, poultry, or fluids. The protein intake index did not show a significant relationship with muscle strength. Conclusions: The results suggest that a diet rich in fruits and vegetables may have a protective effect on muscle strength in older persons. Promoting adequate intake of these foods could be critical in the prevention of sarcopenia in this population. Full article

Dewatering gas wells typically exhibit a high gas–liquid ratio, making tapered electrical submersible pump (ESP) systems a common choice. However, the flow rate within the pump varies significantly along its length, and production parameters fluctuate considerably across different stages of operation for a gas reservoir. Traditional ESP sizing methods typically consider one single operating case and one single pump model. In contrast, tapered ESP systems require the designer to manually select and combine pump models, stage numbers, and operating frequencies based largely on experience. This process can be cumbersome and time-consuming. To address the limitations of existing ESP sizing methods, this study develops a computational program for ESP operation parameters stage by stage and generates extensive training data. A fully connected neural network (FCNN) based on the backpropagation (BP) algorithm is then trained on these data. The model can predict key parameters such as gas volume fraction (GVF) and flow rate along the pump, operating frequency, and total pump efficiency, using input data such as fluid parameters at the pump’s intake and discharge, as well as pump stage numbers and performance curve data. The model demonstrates high accuracy, with a mean absolute error (MAE) of 0.3431, a mean squared error (MSE) of 0.3231, and a coefficient of determination (R²) of 0.9991. By integrating a wellbore two-phase flow model and leveraging industry experience in pump sizing, a hybrid model for automatic ESP sizing under multiple working conditions is proposed, with the objective of maximizing pump efficiency. This model enables optimal pump sizing, calculates the operating frequency corresponding to given working cases, significantly reduces the workload of designers, and enhances the overall design outcomes. Full article

Recurrent urinary tract infection (rUTI) is a significant public health problem in women. General measures to prevent recurrence include behavioral changes and increased fluid intake, cranberry ingest, use of methenamine hippurate, antibiotic prophylaxis, D-mannose, probiotics, or vaccines. We conducted a literature review of the latest updates on preventing rUTI in December 2024. The search concluded with 27 articles that fulfilled our inclusion criteria. Our review demonstrated that behavioral changes such as correct genital hygiene, avoiding postponing micturition or defecation, urinating after sexual intercourse, and ingesting 1.5–2 L of water could prevent rUTI. The ingestion of cranberries reduces the risk of symptomatic, culture-verified urinary tract infections in women with rUTIs. Methenamine hippurate is an alternative to antibiotics to avoid rUTI. Estrogen reduces rUTI in women with hypoestrogenism. Limited evidence supports using D-mannose, probiotics, and vaccines to prevent rUTI. In conclusion, after successful treatment of the acute episode, preventative measures are needed to reduce rUTI frequency and morbidity according to each patient’s characteristics and preferences. Full article

Background: Interdialytic weight gain (IDWG), defined as the accumulation of salt and water intake between dialysis sessions, is a critical parameter of fluid management and a marker of adherence to dietary and fluid restrictions in hemodialysis patients. Excessive IDWG has been strongly associated with increased cardiovascular risk, including left ventricular hypertrophy, cardiac dysfunction, and cerebrovascular complications. Additionally, it necessitates more aggressive ultrafiltration, potentially compromising hemodynamic stability, impairing quality of life, and escalating healthcare costs. Despite international guidelines recommending an IDWG target of <4–4.5% of body weight, many patients struggle to achieve this due to barriers in adhering to dietary and fluid restrictions. This review explores the current state-of-the-art strategies to mitigate IDWG and evaluates emerging diagnostic and therapeutic perspectives to improve fluid management in dialysis patients. Methods: A literature search was conducted in PubMed/MEDLINE, Scopus, and Web of Science to identify studies on IDWG in hemodialysis. Keywords and MeSH terms were used to retrieve peer-reviewed articles, observational studies, RCTs, meta-analyses, and systematic reviews. Non-English articles, case reports, and conference abstracts were excluded. Study selection followed PRISMA guidelines, with independent screening of titles, abstracts, and full texts. Data extraction focused on IDWG definitions, risk factors, clinical outcomes, and management strategies. Due to study heterogeneity, a narrative synthesis was performed. Relevant data were synthesized thematically to evaluate both established strategies and emerging perspectives. Results: The current literature identifies three principal strategies for IDWG control: cognitive–behavioral interventions, dietary sodium restriction, and dialysis prescription adjustments. While educational programs and behavioral counseling improve adherence, their long-term effectiveness remains constrained by patient compliance and logistical challenges. Similarly, low-sodium diets, despite reducing thirst, face barriers to adherence and potential nutritional concerns. Adjustments in dialysate sodium concentration have yielded conflicting results, with concerns regarding hemodynamic instability and intradialytic hypotension. Given these limitations, alternative approaches are emerging. Thirst modulation strategies, including chewing gum to stimulate salivation and acupuncture for autonomic regulation, offer potential benefits in reducing excessive fluid intake. Additionally, technological innovations, such as mobile applications and telemonitoring, enhance self-management by providing real-time feedback on fluid intake. Biofeedback-driven dialysis systems enable dynamic ultrafiltration adjustments, improving fluid removal efficiency while minimizing hemodynamic instability. Artificial intelligence (AI) is advancing predictive analytics by integrating wearable bioimpedance sensors and dialysis data to anticipate fluid overload and refine individualized dialysis prescriptions, driving precision-based volume management. Finally, optimizing dialysis frequency and duration has shown promise in achieving better fluid balance and cardiovascular stability, suggesting that a personalized, multimodal approach is essential for effective IDWG management. Conclusions: Despite decades of research, IDWG remains a persistent challenge in hemodialysis, requiring a multifaceted, patient-centered approach. While traditional interventions provide partial solutions, integrating thirst modulation strategies, real-time monitoring, biofeedback dialysis adjustments, and AI-driven predictive tools represent the next frontier in fluid management. Future research should focus on long-term feasibility, patient adherence, and clinical efficacy, ensuring these innovations translate into tangible improvements in quality of life and cardiovascular health for dialysis patients. Full article

Objectives: Hydration is essential for overall health; therefore, this study aimed to identify associations between hydration status and beverage consumption, anthropometric measures, and urine biochemical analyses in Polish adults. Poland was chosen due to potential regional dietary habits and hydration patterns that may influence hydration status. Methods: A total of 337 participants completed a beverage frequency questionnaire (FFQ). Blood pressure (BP), anthropometric parameters, and body composition were measured. Urine samples were analyzed for specific gravity (USG), osmolality (Uosm), and potential hydrogen value (pH). Hydration status was assessed using the WUT model (weight, urine color, thirst level), classifying participants into two groups: dehydrated (2-3 WUT components) and properly hydrated (0-1 WUT component). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: Approximately 50% of participants (n = 165) exhibited dehydration symptoms, including higher thirst levels, darker urine, and elevated USG and Uosm (p ≤ 0.05). Dehydrated individuals more frequently reported fatigue (p = 0.009), headaches (p = 0.024), and heavy legs (p = 0.002). Higher BMI (OR: 1.49), waist circumference (OR: 1.79), USG (OR: 2.29), and Uosm (OR: 1.75) increased dehydration risk. Conversely, greater consumption of tea (OR: 0.52) and non-carbonated mineral water (OR: 0.45), higher total body water (OR: 0.49), and handgrip strength (OR: 0.81) were linked to lower dehydration risk. Four dietary patterns were identified: Reasonable, Unhealthy, Minimalist, and Loving Sweet Beverages. Conclusions: Multifactorial hydration assessment, combined with preventive strategies such as regular fluid intake and weight management, may improve hydration. The WUT model and Venn diagram provide a practical tool for hydration assessment in clinical and public health. Full article

To optimize the performance of the RC-DTH air hammer, a mathematical model detailing each phase of the piston’s movement has been constructed in the present work. Simultaneously, a novel piston structure of the RC-DTH air hammer (Type B) with diverse internal flow has been proposed. The impact performance of the structurally modified RC-DTH hammer is analyzed using Computational Fluid Dynamics (CFD). Additionally, an impact energy testing system for the RC-DTH air hammer is developed to confirm the validity of the numerical simulation results. Research results have shown that enhancing both the intake stroke of the upper chamber (F₁) and the outlet stroke of the lower chamber (R₂) of the RC-DTH air hammer piston can effectively improve the piston’s impact performance. Conversely, increasing the inlet stroke of the lower chamber (R₁) and the outlet stroke of the upper chamber (F₂) tends to diminish the piston’s impact performance. Moreover, the quality of the piston influences its striking frequency while having a minimal impact on single-impact energy. As the piston quality increases, the power of the impact diminishes. Once the piston valve stroke parameters are optimized, its impact performance is enhanced by 20.32%. Compared to the GQ89 hammer, the Type B hammer exhibits an 84% increase in impact energy and a 74% increase in impact power. Full article

Centrifugal slurry pumps are extensively applied in industrial industries such as power metallurgy, petrochemicals, deep-sea mining, and other industrial fields. The primary objective of this research is to assess how conveying settings and particle characteristics influence the 100SHL4147 slurry pump’s collision and erosion properties. Firstly, the computational fluid dynamics–discrete element method (CFD-DEM) coupling model fully coupled particle–fluid co-flow numerical simulation interface is built by utilizing the C++ language and the results are proven with tests. Subsequently, the simulation examines the wear properties of different sections through which the flow passes in the 100SHL4147 centrifugal slurry pump. In addition, following theoretical guidance, the slurry pump impeller’s wear resistance performance can be improved by adjusting design factors such as the intake edge location and the blade wrap angle. The results are as follows. It is recommended to replace the impeller promptly due to the findings that indicate that the entire blade’s pressure surface is vulnerable to different degrees of erosion under high-concentration situations. When the particle size increased from 0.4 to 0.8 mm, the wear rate decreased by up to 15%, as fewer particles were transported, lowering the collision frequency. Conversely, smaller particles intensify component wear. Adjusting the blade wrap angle from 66° to 96° reduced impeller and volute wear by an estimated 20%, enhancing the durability but slightly decreasing the delivery capacity. Extending the blade’s leading edge toward the intake improved the flow capacity, although it increased the wear frequency from one-third of the pressure surface to the trailing edge. Full article

Background: Lower urinary tract symptoms (LUTSs) are a common complaint in adult and elderly men with bladder outlet obstruction, and have a considerable impact on their quality of life. Symptoms affect storage, voiding and post micturition stages. Among the latter, a feeling of incomplete emptying is one of the most bothersome for the patients; a condition that in turn contributes to affect urinary urgency, nocturia and frequency. Common recommendations include self-management practices (e.g., control of fluid intake, double-voiding and distraction techniques) to relieve patients’ symptoms, whose effectiveness, however, is under debate. Methods: In this report we describe two pioneering procedures to favor bladder residual content voiding in people complaining of LUTS disorders. The first is based on motor imagery and the second on the use of odors. The beneficial effects of Mental imagery techniques on various tasks (e.g., in the treatment of several pathological conditions or as valid mnemonics aids have a long tradition and have received consistently experimental support. Thus, a patient (a 68-year-old Caucasian man) complaining of LUTS was trained to use a motor imagery technique (building up a visual image comprising the bladder, the detrusor muscle and the urethra, and to imagine the detrusor muscle contracting and the flow of urine expelled) for 90 days and two odors (coffee and a lavender scented cleanser) for 10 days, as a trigger for micturition. He was asked to record—immediately after the first morning micturition—the time interval between the first (free) and the second (cued) micturition. Results: Reported data suggest the efficacy of motor imagery in favoring the bladder residual urine voiding in a few minutes (M = 4.75 min.) compared to the control condition, i.e., the baseline of the patient (M = 79.5 min.), while no differences between the odor-based procedures (M 1st odorant = 70.6 min.; M 2nd odorant = 71.1 min) and the latter were observed. Conclusions: A procedure based on an imagery technique may, therefore, be of general value—as a suggested protocol—and accordingly can be applicable to clinical settings. An olfactory bladder control hypothesis cannot, however, be ruled out and is discussed as a promising future line of research. Full article

Dental erosion represents the gradual and irreversible depletion of dental hard tissues due to a chemical process, independent of bacterial influence. It has emerged as a notable clinical concern in recent years, primarily attributed to substantial lifestyle shifts resulting in the heightened intake and frequency of acid-containing foods and beverages. Apart from the extrinsic erosive agents derived from external sources, such as dietary habits or medication, intrinsic erosive agents may exist due to pathological reasons with the contents of the stomach including gastric juice, mainly composed of hydrochloric acid, being their sole source. Currently, bioactive materials are used in various forms for the prevention of dental erosion. Such materials include, among others, bioactive glasses (BAGs). BAGs are a type of glass that, when in contact with biological fluids, can elicit a specific biological response. When they come into contact with bodily fluids, they can initiate a series of processes, including the formation of a hydroxyapatite layer on the glass surface. This bioactivity is particularly advantageous in medical and dental applications, where BAGs are used for bone regeneration, tissue repair, and dental restorative or preventive techniques. The aim of this literature review was to analyze and discuss the role of BAGs in protecting the tooth structures from dental erosion. The analysis of the existing literature regarding this topic indicated that the use of BAGs in preventive treatments against tooth erosion can be useful in dental practice. Further clinical evidence is necessary to confirm the effectiveness of the particular preventive measures. Full article

Gyrophoric acid (GA), a lichen secondary metabolite, has attracted more attention during the last years because of its potential biological effects. Until now, its effect in vivo has not yet been demonstrated. The aim of our study was to evaluate the basic physicochemical and pharmacokinetic properties of GA, which are directly associated with its biological activities. The stability of the GA in various pH was assessed by conducting repeated UV-VIS spectral measurements. Microsomal stability in rat liver microsomes was performed using Ultra-Performance LC/MS. Binding to human serum albumin (HSA) was assessed using synchronous fluorescence spectra, and molecular docking analysis was used to reveal the binding site of GA to HSA. In the in vivo experiment, 24 Sprague-Dawley rats (Velaz, Únetice, Czech Republic) were used. The animals were divided as follows. The first group (n = 6) included healthy males as control intact rats (♂INT), and the second group (n = 6) included healthy females as controls (♀INT). Groups three and four (♂GA/n = 6 and ♀GA/n = 6) consisted of animals with daily administered GA (10 mg/kg body weight) in an ethanol-water solution per os for a one-month period. We found that GA remained stable under various pH and temperature conditions. It bonded to human serum albumin with the binding constant 1.788 × 10⁶ dm³mol⁻¹ to reach the target tissue via this mechanism. In vivo, GA did not influence body mass gain, food, or fluid intake during the experiment. No liver toxicity was observed. However, GA increased the rearing frequency in behavioral tests (p < 0.01) and center crossings in the elevated plus-maze (p < 0.01 and p < 0.001, respectively). In addition, the time spent in the open arm was prolonged (p < 0.01 and p < 0.001, respectively). Notably, GA was able to pass through the blood–brain barrier, indicating its ability to permeate into the brain and to stimulate neurogenesis in the hilus and subgranular zone of the hippocampus. These observations highlight the potential role of GA in influencing brain function and neurogenesis. Full article

The association of hydration knowledge and health habits with hydration status and fluid intake is rarely examined. We sought to determine whether knowledge or physical health behaviors predict physiological hydration status and fluid intake. Ninety-six participants (59 female; 27 ± 10 year) completed the previously validated hydration survey. Participants then recorded total fluids consumed (TFC), collected urine, and tracked void frequency for 24 h. Hydration status was assessed via 24 h urine specific gravity (USG) and osmolality (U_osm). Health behaviors included self-reported physical activity, BMI, smoking, alcoholic drinking, and sleep status. TFC was significantly correlated with 24 h USG (r = −0.390; p < 0.001), U_osm (r = −0.486; p < 0.001), total urine volume (r = 0.675; p < 0.001), and void frequency (r = 0.518; p < 0.001). Hydration knowledge was not correlated with 24 h USG (r = 0.085; p = 0.420), U_osm (r = 0.087; p = 0.419), urine total volume (r = 0.019; p = 0.857), void frequency (r = 0.030; p = 0.771), or TFC (r = 0.027; p = 0.813). Hydration knowledge did not predict 24 h USG (LR⁺ = 1.10; LR⁻ = 0.90), U_osm (LR⁺ = 0.81; LR⁻ = 1.35), or TFC (LR⁺ = 1.00; LR⁻ = 1.00). Health habits did not predict 24 h USG, U_osm, or TFC. In conclusion, self-reported 24 h diet and fluid log recording is comparable to hydration status verification via 24 h urine collection. Hydration knowledge and health habits are not related to, or predictive of, hydration status. Full article

A continuous flow with reagent injection method on a novel inlaid microfluidic platform for nitrite determination has been successfully developed. The significance of the high-frequency monitoring of nutrient fluctuations in marine environments is crucial for understanding our impacts on the ecosystem. Many in-situ systems face limitations in high-frequency data collection and have restricted deployment times due to high reagent consumption. The proposed microfluidic device employs automatic colorimetric absorbance spectrophotometry, using the Griess assay for nitrite determination, with minimal reagent usage. The sensor incorporates 10 solenoid valves, four syringes, two LEDs, four photodiodes, and an inlaid microfluidic technique to facilitate optical measurements of fluid volumes. In this flow system, Taylor–Aris dispersion was simulated for different injection volumes at a constant flow rate, and the results have been experimentally confirmed using red food dye injection into a carrier stream. A series of tests were conducted to determine a suitable injection frequency for the reagent. Following the initial system characterization, seven different standard concentrations ranging from 0.125 to 10 µM nitrite were run through the microfluidic device to acquire a calibration curve. Three different calibrations were performed to optimize plug length, with reagent injection volumes of 4, 20, and 50 µL. A straightforward signal processing method was implemented to mitigate the Schlieren effect caused by differences in refractive indexes between the reagent and standards. The results demonstrate that a sampling frequency of at least 10 samples per hour is achievable using this system. The obtained attenuation coefficients exhibited good agreement with the literature, while the reagent consumption was significantly reduced. The limit of detection for a 20 µL injection volume was determined to be 94 nM from the sample intake, and the limit of quantification was 312 nM. Going forward, the demonstrated system will be packaged in a submersible enclosure to facilitate in-situ colorimetric measurements in marine environments. Full article