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Search Results (302)

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Keywords = fixed-bearing

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18 pages, 4253 KiB  
Article
Influence of Design Parameters of Membrane-Type Flow Controller on Bearing Characteristics of Hydrostatic Guideways
by Yi Chen, Xiaoyu Xu, Ziqi Lin, Maoyuan Li, Guo Bi and Zhenzhong Wang
Micromachines 2025, 16(8), 891; https://doi.org/10.3390/mi16080891 (registering DOI) - 30 Jul 2025
Viewed by 117
Abstract
The hydrostatic guideway has been widely used in ultra-precision machine tools. The flow stability of the hydrostatic guideway has a significant impact on its bearing characteristics, and the flow controller is critical to safeguard the flow stability of the hydrostatic guideway. Currently, most [...] Read more.
The hydrostatic guideway has been widely used in ultra-precision machine tools. The flow stability of the hydrostatic guideway has a significant impact on its bearing characteristics, and the flow controller is critical to safeguard the flow stability of the hydrostatic guideway. Currently, most engineering applications use fixed, fluid-resistance flow controllers, which have a simple structure, low cost, and high reliability. However, when facing complex working conditions, the fixed, fluid-resistance flow controller cannot maintain the flow stability of the hydrostatic guide. In this study, a membrane-type flow controller with variable fluid resistance is designed, and a theoretical model of the flow controller’s bearing characteristics is established, which is verified by fluid–solid coupling simulation and flow rate experiments. Analyzing the influence of the design parameters of the membrane-type flow controller on the performance according to the theoretical model, the design guidelines of the membrane-type flow controller are established, the key structure of the flow controller is clarified, and the design range of the key structure dimensions is given. The results show that the gasket thickness of the membrane-type flow controller has the greatest impact on the performance of the hydrostatic guideways, which should be ensured to have a machining error of less than 0.005 mm. This study is a guide for the design and manufacture of flow controllers, as well as for engineering applications. Full article
(This article belongs to the Section E:Engineering and Technology)
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40 pages, 1430 KiB  
Article
A Stress Analysis of a Thin-Walled, Open-Section, Beam Structure: The Combined Flexural Shear, Bending and Torsion of a Cantilever Channel Beam
by David W. A. Rees
Appl. Sci. 2025, 15(15), 8470; https://doi.org/10.3390/app15158470 - 30 Jul 2025
Viewed by 98
Abstract
Channels with three standard symmetrical sections and one asymmetric section are mounted as cantilever beams with the web oriented vertically. A classical solution to the analysis of stress in each thin-walled cantilever channel is provided using the principle of wall shear flow superposition. [...] Read more.
Channels with three standard symmetrical sections and one asymmetric section are mounted as cantilever beams with the web oriented vertically. A classical solution to the analysis of stress in each thin-walled cantilever channel is provided using the principle of wall shear flow superposition. The latter is coupled with a further superposition between axial stress arising from bending and from the constraint placed on free warping imposed at the fixed end. Closed solutions for design are tabulated for the net shear stress and the net axial stress at points around any section within the length. Stress distributions thus derived serve as a benchmark structure for alternative numerical solutions and for experimental investigations. The conversion of the transverse free end-loading applied to a thin-walled cantilever channel into the shear and axial stress that it must bear is outlined. It is shown that the point at which this loading is applied within the cross-section is crucial to this stress conversion. When a single force is applied to an arbitrary point at the free-end section, three loading effects arise generally: bending, flexural shear and torsion. The analysis of each effect requires that this force’s components are resolved to align with the section’s principal axes. These forces are then considered in reference to its centroid and to its shear centre. This shows that axial stress arises directly from bending and from the constraint imposed on free warping at the fixed end. Shear stress arises from flexural shear and also from torsion with a load offset from the shear centre. When the three actions are combined, the net stresses of each action are considered within the ability of the structure to resist collapse from plasticity and buckling. The novelty herein refers to the presentation of the shear flow calculations within a thin wall as they arise from an end load offset from the shear centre. It is shown how the principle of superposition can be applied to individual shear flow and axial stress distributions arising from flexural bending, shear and torsion. Therein, the new concept of a ‘trans-moment’ appears from the transfer in moments from their axes through centroid G to parallel axes through shear centre E. The trans-moment complements the static equilibrium condition, in which a shift in transverse force components from G to E is accompanied by torsion and bending about the flexural axis through E. Full article
21 pages, 1210 KiB  
Article
Fixed-Time Bearing-Only Formation Control Without a Global Coordinate Frame
by Hanqiao Huang, Mengwen Lu, Bo Zhang and Qian Wang
Electronics 2025, 14(15), 3021; https://doi.org/10.3390/electronics14153021 - 29 Jul 2025
Viewed by 122
Abstract
This work addresses distributed fixed-time bearing-only formation stabilization for multi-agent systems lacking shared orientation knowledge. Addressing the challenge of missing global coordinate alignment in multi-agent systems, this work introduces a novel distributed estimator ensuring almost globally fixed-time convergence of orientation estimates. Leveraging this [...] Read more.
This work addresses distributed fixed-time bearing-only formation stabilization for multi-agent systems lacking shared orientation knowledge. Addressing the challenge of missing global coordinate alignment in multi-agent systems, this work introduces a novel distributed estimator ensuring almost globally fixed-time convergence of orientation estimates. Leveraging this estimator, we develop a distributed bearing-only formation control law specifically designed for agents governed by double-integrator dynamics, guaranteeing fixed-time convergence. Comprehensive stability analysis proves the almost global fixed-time stability of the overall closed-loop system. Crucially, the proposed control strategy drives actual formation to achieve the desired geometric pattern with almost global exponential convergence within a fixed time bound. Rigorous numerical experiments corroborate the theoretical framework. Full article
(This article belongs to the Special Issue Research on Cooperative Control of Multi-agent Unmanned Systems)
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22 pages, 11766 KiB  
Article
Seismic Performance of Tall-Pier Girder Bridge with Novel Transverse Steel Dampers Under Near-Fault Ground Motions
by Ziang Pan, Qiming Qi, Ruifeng Yu, Huaping Yang, Changjiang Shao and Haomeng Cui
Buildings 2025, 15(15), 2666; https://doi.org/10.3390/buildings15152666 - 28 Jul 2025
Viewed by 120
Abstract
This study develops a novel transverse steel damper (TSD) to enhance the seismic performance of tall-pier girder bridges, featuring superior lateral strength and energy dissipation capacity. The TSD’s design and arrangement are presented, with its hysteretic behavior simulated in ABAQUS. Key parameters (yield [...] Read more.
This study develops a novel transverse steel damper (TSD) to enhance the seismic performance of tall-pier girder bridges, featuring superior lateral strength and energy dissipation capacity. The TSD’s design and arrangement are presented, with its hysteretic behavior simulated in ABAQUS. Key parameters (yield strength: 3000 kN; initial gap: 100 mm; post-yield stiffness ratio: 15%) are optimized through seismic analysis under near-fault ground motions, incorporating pulse characteristic investigations. The optimized TSD effectively reduces bearing displacements and results in smaller pier top displacements and internal forces compared to the bridge with fixed bearings. Due to the higher-order mode effects, there is no direct correlation between top displacements and bottom internal forces. As pier height decreases, the S-shaped shear force and bending moment envelopes gradually become linear, reflecting the reduced influence of these modes. Medium- to long-period pulse-like motions amplify seismic responses due to resonance (pulse period ≈ fundamental period) or susceptibility to large low-frequency spectral values. Higher-order mode effects on bending moments and shear forces intensify under prominent high-frequency components. However, the main velocity pulse typically masks the influence of high-order modes by the overwhelming seismic responses due to large spectral values at medium to long periods. Full article
(This article belongs to the Special Issue Seismic Analysis and Design of Building Structures)
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25 pages, 7677 KiB  
Article
Seismic Assessment and Strengthening of a Load-Bearing Masonry Structure Considering SSI Effects
by Kyriaki G. Amarantidou, Panagiota S. Katsimpini, George Papagiannopoulos and George Hatzigeorgiou
Appl. Sci. 2025, 15(15), 8135; https://doi.org/10.3390/app15158135 - 22 Jul 2025
Viewed by 332
Abstract
This article examines the seismic assessment and strengthening of a traditional load-bearing masonry structure subjected to strong motion data, with particular emphasis on the effects of soil–structure interaction (SSI). The case study is the Archaeological Museum of Lemnos (AML)—a three-storey building with a [...] Read more.
This article examines the seismic assessment and strengthening of a traditional load-bearing masonry structure subjected to strong motion data, with particular emphasis on the effects of soil–structure interaction (SSI). The case study is the Archaeological Museum of Lemnos (AML)—a three-storey building with a composite load-bearing system of timber-framed stone masonry. Over time, the structure has undergone irreversible modifications, primarily involving reinforced concrete (RC) interventions. The building’s seismic performance was evaluated using two finite element models developed in the SAP2000 software (v. 25.3.00). The first model simulates the original structure, strengthened by grout injections, while the second represents the current condition of the structural system following RC additions. Soil–structure interaction was also investigated, given that the local soil is classified as Category D according to Eurocode 8 (EC8). Each model was analyzed under two different support conditions: fixed-base and SSI-inclusive. A suite of appropriate accelerograms was applied to both models, in compliance with Eurocode 8 using the SeismoMatch software, and linear time-history analyses were conducted. The results underscore the significant impact of SSI on the increase of peak tensile stress and interstorey drift ratios (IDRs), and highlight the influence of different strengthening techniques on the seismic response of historic load-bearing masonry structures. Full article
(This article belongs to the Special Issue Vibration Monitoring and Control of the Built Environment)
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32 pages, 10923 KiB  
Article
Numerical Simulation of Hydrodynamic Characteristics for Monopile Foundations of Wind Turbines Under Wave Action
by Bin Wang, Mingfu Tang, Zhenqiang Jiang and Guohai Dong
Water 2025, 17(14), 2068; https://doi.org/10.3390/w17142068 - 10 Jul 2025
Viewed by 232
Abstract
The calculation and evaluation of wave loads represent a critical component in the design process of offshore wind turbines, which is of significant value for ensuring the safety and stability of offshore wind turbines during operation. In recent years, as the offshore wind [...] Read more.
The calculation and evaluation of wave loads represent a critical component in the design process of offshore wind turbines, which is of significant value for ensuring the safety and stability of offshore wind turbines during operation. In recent years, as the offshore wind power industry has extended into deep-sea areas, wind turbines and their foundation structures have gradually increased in scale. Due to the continuously growing diameter of fixed foundation structures, the wave loads they endure can no longer be evaluated solely by traditional methods. This study simplifies the monopile foundation structure of wind turbines into an upright circular cylinder. The open-source CFD platform OpenFOAM is employed to establish a numerical wave tank, and large eddy simulation (LES) models are used to conduct numerical simulations of its force-bearing process in wave fields. Through this approach, the hydrodynamic loads experienced by the single-cylinder structure in wave fields and the surrounding wave field data are obtained, with further investigation into its hydrodynamic characteristics under different wave environments. By analyzing the wave run-up distribution around cylinders of varying diameters and their effects on incident waves, a more suitable value range for traditional theories in engineering design applications is determined. Additionally, the variation laws of horizontal wave loads on single-cylinder structures under different parameter conditions (such as cylinder diameter, wave steepness, water depth, etc.) are thoroughly studied. Corresponding hydrodynamic load coefficients are derived, and appropriate wave force calculation methods are established to address the impact of value errors in hydrodynamic load coefficients within the transition range from large-diameter to small-diameter cylinders in traditional theories on wave force evaluation. This contributes to enhancing the accuracy and practicality of engineering designs. Full article
(This article belongs to the Section Oceans and Coastal Zones)
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20 pages, 5814 KiB  
Article
The Effect of Inflatable Pressure on the Strain Deformation of Flexible Wing Skin Film
by Longbin Liu, Mengyang Fan and Xingfu Cui
Appl. Sci. 2025, 15(13), 7596; https://doi.org/10.3390/app15137596 - 7 Jul 2025
Viewed by 225
Abstract
Flexible inflatable film wings have many functional advantages that traditional fixed rigid wings do not possess, such as foldability, small size, light weight, convenient storage, transportation, and so on. More and more scholars and engineers are paying attention to flexible inflatable wings, which [...] Read more.
Flexible inflatable film wings have many functional advantages that traditional fixed rigid wings do not possess, such as foldability, small size, light weight, convenient storage, transportation, and so on. More and more scholars and engineers are paying attention to flexible inflatable wings, which have gradually become a new hot research topic. However, flexible wings rely on inflation pressure to maintain the shape and rigidity of the skin film, and the inflation pressure has a significant influence on the strain deformation and wing bearing characteristics of flexible wing skin film. Here, based on the flexible mechanics theory and balance principle of flexible inflatable film, a theoretical model of structural deformation and internal inflation pressure was constructed, and finite element simulation analysis under different internal inflation pressure conditions was carried out as well. The results demonstrate that the biaxial deformation of flexible wing skin film is closely related to internal inflation pressure, local size, configuration, and film material properties. However, strain deformation along the wingspan direction is quite distinguishing, skin films work under the condition of biaxial plane deformation, and the strain deformation of the spanning direction is obviously higher than that of the chord direction, which all increases with internal inflation pressure. Therefore, it is necessary to pay more attention to bearing strain deformation characteristics to meet the bearing stiffness requirements, which could effectively provide a theoretical reference for the structural optimization design and inflation scheme setting of flexible inflatable wings. Full article
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23 pages, 5894 KiB  
Article
Characteristics of Deep Coal Reservoirs Based on Logging Parameter Responses and Laboratory Data: A Case Study of the Logging Response Analysis of Reservoir Parameters Is Carried Out in Ordos Basin, China
by Xiaoming Yang, Jingbo Zeng, Die Liu, Yunhe Shi, Hongtao Gao, Lili Tian, Yufei He, Fengsheng Zhang and Jitong Su
Processes 2025, 13(7), 2062; https://doi.org/10.3390/pr13072062 - 29 Jun 2025
Viewed by 332
Abstract
The coal reservoir in the Ordos Mizhi block is buried at a depth of over 2000 m. This study aims to obtain the characteristics of the coal reservoir in the Mizhi block through various experimental methods and combine the gas-bearing characteristics obtained from [...] Read more.
The coal reservoir in the Ordos Mizhi block is buried at a depth of over 2000 m. This study aims to obtain the characteristics of the coal reservoir in the Mizhi block through various experimental methods and combine the gas-bearing characteristics obtained from on-site desorption experiments to analyze the gas content and logging response characteristics of the study area. On this basis, a reservoir parameter interpretation model for the study area is established. This provides a reference for the exploration and development of coal-rock gas in the Mizhi block. The research results show that: (1) The study area is characterized by the development of the No. 8 coal reservoirs of the Benxi Formation, with a thickness ranging from 2 to 11.6 m, averaging 7.2 m. The thicker coal reservoirs provide favorable conditions for the formation and storage of coal-rock gas. The lithotypes are mainly semi-bright and semi-dark. The coal maceral is dominated by the content of the vitrinite, followed by the inertinite, and the exinite is the least. The degree of metamorphism is high, making it a high-grade coal. In the proximate analysis, the moisture ranges from 0.36 to 1.09%, averaging 0.65%. The ash ranges from 2.34 to 42.17%, averaging 16.57%. The volatile ranges from 9.18 to 15.7%, averaging 11.50%. The fixed carbon ranges from 45.24 to 87.51%, averaging 71.28%. (2) According to the results of scanning electron microscopy (SEM), the coal samples in the Mizhi block have developed fractures and pores. Based on the results of the carbon dioxide adsorption experiment, the micropore adsorption capacity is 7.8728–20.3395 cm3/g, with an average of 15.2621 cm3/g. The pore volume is 0.02492–0.063 cm3/g, with an average of 0.04799 cm3/g. The specific surface area of micropores is 79.514–202.3744 m2/g, with an average of 153.5118 m2/g. The micropore parameters are of great significance for the occurrence of coal-rock gas. Based on the results of the desorption experiment, the gas content of the coal rock samples in the study area is 12.97–33.96 m3/t, with an average of 21.8229 m3/t, which is relatively high. (3) Through the correlation analysis of the logging parameters of the coal reservoir, the main logging response parameters of the reservoir are obtained. Based on the results of the logging sensitivity analysis of the coal reservoir, the interpretation model of the reservoir parameters is constructed and verified. Logging interpretation models for parameters such as industrial components, microscopic components, micropore pore parameters, and gas content are obtained. The interpretation models have interpretation effects on the reservoir parameters in the study area. Full article
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25 pages, 5206 KiB  
Article
Compressive Behavior of Waste-Steel-Fiber-Reinforced Concrete-Filled Steel Tubes with External Steel Rib Rings
by Jianhua Gao, Xiaopeng Ren, Yongtao Gao, Youzhi Li and Mingshuai Li
Buildings 2025, 15(13), 2246; https://doi.org/10.3390/buildings15132246 - 26 Jun 2025
Viewed by 287
Abstract
In order to explore the axial compression performance of external steel rib ring restraint waste-steel-fiber-reinforced concrete-filled steel tubes (ERWCFSTs), 18 short-column axial compression tests were conducted. The effects of the number of rib rings, rib ring spacing, rib ring setting position, and waste [...] Read more.
In order to explore the axial compression performance of external steel rib ring restraint waste-steel-fiber-reinforced concrete-filled steel tubes (ERWCFSTs), 18 short-column axial compression tests were conducted. The effects of the number of rib rings, rib ring spacing, rib ring setting position, and waste steel fiber (WSF) content on the axial compression performance of the columns were analyzed. The results show that the concrete-filled steel tube (CFST) short columns with rib rings were strengthened, the specimens were mainly characterized by drum-shaped failure, and the buckling was concentrated between the rib rings. Without rib ring specimens, the steel tube is unable to resist the rapid increase in lateral expansion, leading to buckling initiation near the bottom of the specimens. The columns with rib rings exhibited a minimum increase of 32.5% and a maximum increase of 53.17% in load-bearing capacity compared to those without rib rings, with an average improvement of 37.78%. The columns achieved the best ductility when the rib ring spacing was 50 mm. When the rib ring spacing remained constant, columns with a number of rib rings no less than the height-to-diameter ratio (H/D) demonstrated more uniform stress distribution and optimal confinement effects. For a fixed number of rib rings, specimens with rib ring spacing between H/8 and H/4 showed significant improvements in both load-bearing capacity and ductility. The confinement effect was better when the rib rings were positioned in the middle of the column height rather than near the ends. The incorporation of WSF resulted in a minimum increase of 2.86% and a maximum increase of 10.49% in column load-bearing capacity, indicating limited enhancement. However, WSF improved the ductility performance of the columns by at least 10%. Combined with theoretical analysis and experimental data, a formula for calculating the bearing capacity of ERWCFSTs was established. Full article
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19 pages, 5013 KiB  
Article
Experimental Testing and PSO-Enhanced Neural Networks for Impact Failure Analysis of H-Section Steel Members
by Pengcheng Chen, Shuwen Bu, Lin Wang, Guoyun Lu, Jinfeng Jiao and Huiwei Yang
Materials 2025, 18(13), 2968; https://doi.org/10.3390/ma18132968 - 23 Jun 2025
Viewed by 277
Abstract
H-section steel members, as a commonly used load-bearing receiving member in building structures, may be subjected to the impact of accidental loads during their service life, and therefore, the impact loads need to be considered when carrying out the design. In this paper, [...] Read more.
H-section steel members, as a commonly used load-bearing receiving member in building structures, may be subjected to the impact of accidental loads during their service life, and therefore, the impact loads need to be considered when carrying out the design. In this paper, based on experimental testing, the particle swarm optimization algorithm (PSO) is used to optimize the hyperparameters of the multilayer perceptron (MLP), and a combined prediction model PSO-MLP for H-section steel members subjected to lateral impact loads is proposed to predict the damage of the H-section steel members after impact. The results show that the prediction model based on PSO-MLP can predict the damage of the H-beam columns more accurately, and compared to the random forest model (RF) and the support vector machine (SVM), the PSO-MLP model has better prediction accuracy and robustness. In addition, the effects of different features on the impact performance of the members were analyzed, in which the weakest impact location is 0.57 L away from the fixed end and the effects of axial compression ratio, flange, and web thickness were similar to the results of previous studies; the impact angle showed a strong nonlinear relationship with the critical impact velocity, which the weakest impact angle is around 50° from the strong axle; and the height and width of the cross-section showed a linear enhancement of the impact performance. Full article
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15 pages, 3484 KiB  
Article
Construction of a Mathematical Model of the Irregular Plantar and Complex Morphology of Mallard Foot and the Bionic Design of a High-Traction Wheel Grouser
by Jinrui Hu, Dianlei Han, Changwei Li, Hairui Liu, Lizhi Ren and Hao Pang
Biomimetics 2025, 10(6), 390; https://doi.org/10.3390/biomimetics10060390 - 11 Jun 2025
Viewed by 427
Abstract
To improve the traction performance of mobile mechanisms on soft ground, such as paddy fields, tidal flats, and swamps, a mallard (Anas platyrhynchos) foot was adopted as a bionic prototype to explore the influence and contribution of the plantar morphology of the toes [...] Read more.
To improve the traction performance of mobile mechanisms on soft ground, such as paddy fields, tidal flats, and swamps, a mallard (Anas platyrhynchos) foot was adopted as a bionic prototype to explore the influence and contribution of the plantar morphology of the toes and webbing on the anti-subsidence function during its locomotion on wet and soft substrates and to apply this to the bionic design of high-traction wheel grousers. A handheld three-dimensional laser scanner was used to scan the main locomotion postures of a mallard foot during ground contact, and the Geomagic Studio software was utilized to repair the scanned model. As a result, the main three-dimensional geometric models of a mallard foot during the process of touching the ground were obtained. The plantar morphology of a mallard foot was divided into three typical parts: the plantar irregular edge curve, the lateral webbing surface, and the medial webbing surface. The main morphological feature curves/surfaces were extracted through computer-aided design software for the fitting and construction of a mathematical model to obtain the fitting equations of the three typical parts, and the mathematical model construction of the plantar irregular morphology of the mallard foot was completed. In order to verify the sand-fixing and flow-limiting characteristics of this morphological feature, based on the discrete element method (DEM), the numerical simulation of the interaction between the plantar surface of the mallard foot and sand particles was carried out. The simulation results show that during the process of the mallard foot penetration into the loose medium, the lateral and medial webbing surfaces cause the particles under the foot to mainly move downward, effectively preventing the particles from spreading around and significantly enhancing the solidification effect of the particles under the sole. Based on the principle and technology of engineering bionics, the plantar morphology and movement attitude characteristics of the mallard were extracted, and the characteristics of concave middle and edge bulge were applied to the wheel grouser design of paddy field wheels. Two types of bionic wheel grousers with different curved surfaces were designed and compared with the traditional wheel grousers of the paddy field wheel. Through pressure-bearing simulation and experiments, the resistance of different wheel grousers during the process of penetrating into sand particles was compared, and the macro–micro behaviors of particle disturbance during the pressure-bearing process were analyzed. The results show that a bionic wheel grouser with unique curved surfaces can well encapsulate sand particles at the bottom of the wheel grouser, and it also has a greater penetration resistance, which plays a crucial role in improving the traction performance of the paddy field wheel and reducing the disturbance to the surrounding sand particles. This paper realizes the transformation from the biological model to the mathematical model of the plantar morphology of the mallard foot and applies it to the bionic design of the wheel grousers of the paddy field wheels, providing a new solution for improving the traction performance of mobile mechanisms on soft ground. Full article
(This article belongs to the Special Issue Bioinspired Engineered Systems)
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12 pages, 668 KiB  
Article
Xenogeneic Testicular Cell Vaccination Induces Long-Term Anti-Cancer Immunity in Mice
by Victor I. Seledtsov, Ayana B. Dorzhieva, Adas Darinskas, Alexei A. von Delwig, Elena A. Blinova and Galina V. Seledtsova
Curr. Issues Mol. Biol. 2025, 47(6), 443; https://doi.org/10.3390/cimb47060443 - 10 Jun 2025
Viewed by 1177
Abstract
Cancer/testis antigen (CTA) gene products are expressed in most malignant tumours, while under normal conditions their expression is primarily restricted to testicular cells. In this study, we investigated the prophylactic application of a xenogeneic (ram-derived) testicular cell (TC) vaccine for cancer prevention in [...] Read more.
Cancer/testis antigen (CTA) gene products are expressed in most malignant tumours, while under normal conditions their expression is primarily restricted to testicular cells. In this study, we investigated the prophylactic application of a xenogeneic (ram-derived) testicular cell (TC) vaccine for cancer prevention in an experimental animal model. C57BL/6 mice were immunised three times with either xenogeneic (ram) or syngeneic (mouse) formaldehyde-fixed spermatogenic tissue-derived cells. Following vaccination, mice were implanted with live B16 melanoma or LLC carcinoma cells. Tumour-bearing mice were subsequently assessed for survival and immunological parameters indicative of anti-cancer immunity. Xenogeneic vaccination with TCs induced cross-reactive immune responses to both B16 melanoma and LLC carcinoma antigens (Ags), as determined by an MTT ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Prophylactic vaccination with xenogeneic TCs (xTCs), but not syngeneic TCs (sTCs), significantly improved survival rates, with 30% of vaccinated mice surviving after LLC carcinoma implantation. The induced immunity was long-lasting as mice implanted with LLC carcinoma cells 3–6 months post-vaccination exhibited prolonged survival. Furthermore, lymphoid cells from surviving vaccinated mice were capable of adoptively transferring anti-cancer immunity to naïve animals, significantly increasing their survival rates upon subsequent LLC carcinoma cell implantation. Vaccinated mice bearing LLC tumours exhibited a reduction in regulatory CD4⁺CD25⁺Foxp3⁺ T cells in the spleen, with no effect observed in the central memory CD4⁺CD44⁺CD62L⁺ T-cell compartment. Moreover, vaccinated mice displayed increased interferon gamma (IFN-γ) levels in the blood, with no significant changes in interleukin-10 (IL-10) levels. Prophylactic vaccination with xenogeneic CTAs effectively induces long-term, stable anti-cancer immunity, demonstrating potential for future immunopreventive strategies. Full article
(This article belongs to the Section Molecular Medicine)
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23 pages, 2627 KiB  
Article
Using Continuous Flight Auger Pile Execution Energy to Enhance Reliability and Reduce Costs in Foundation Construction
by Darym Júnior Ferrari de Campos, José Camapum de Carvalho, Paulo Ivo Braga de Queiroz, Luan Carlos Sena Monteiro Ozelim, José Antonio Schiavon, Dimas Betioli Ribeiro and Vinicius Resende Domingues
Automation 2025, 6(2), 24; https://doi.org/10.3390/automation6020024 - 9 Jun 2025
Viewed by 889
Abstract
Continuous flight auger piles (CFAPs) are highly versatile and productive deep foundation elements. Known for their execution speed, low noise, and minimal vibration, they are extensively used in Brazil, particularly for urban projects or environmentally sensitive areas. Technologically, they employ a Real-Time Operation [...] Read more.
Continuous flight auger piles (CFAPs) are highly versatile and productive deep foundation elements. Known for their execution speed, low noise, and minimal vibration, they are extensively used in Brazil, particularly for urban projects or environmentally sensitive areas. Technologically, they employ a Real-Time Operation System (RTOS) to control the execution energy for each drilled pile. When used effectively, this energy-based monitoring system can provide information that replaces or correlates with other challenging-to-measure variables, accommodating the impact of various exogenous variables on a pile’s execution and performance. Foundation designers often define one or more characteristic lengths for different pile groups, considered representative for each group despite uncertainties and morphological changes along the terrain. Hence, considering an energy-based control, which enables an individual assessment for each pile, is beneficial given soil’s complexity, which can vary significantly even within a small area. By determining the optimal execution energy, individualized stopping criteria for piles can be established, directly influencing costs and productivity and enhancing reliability. The present paper proposes a methodological workflow to automate the necessary calculations for execution energies, correlate them with bearing capacities measured by load tests or estimated from standard soil surveys, and predict the execution energy and corresponding stopping criteria for the drilling depth of each pile. This study presents a case study to illustrate the methodology proposed, accounting for a real construction site with multiple piles. It shows that considering fixed-length piles may not favor safety, as the energy-based analysis revealed that some piles needed longer shafts. This study also shows that for the 316 CFAPs analyzed with depths ranging from 8 to 14 m, a total of 564 m of pile shafts was unnecessary (which accounted for more than 110 m3 of concrete), indicating that cost optimization is possible. Overall, these analyses improve design safety and reliability while reducing execution costs. The results demonstrate that execution energy can serve as a proxy for subsurface resistance, correlating well with NSPT values and bearing capacity estimations. The methodology enables the individualized assessment of pile performance and reveal the potential for improving the reliability and cost-effectiveness of the geotechnical design process. Full article
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44 pages, 4172 KiB  
Article
A Novel Nature-Inspired Optimization Algorithm: Grizzly Bear Fat Increase Optimizer
by Moslem Dehghani, Mokhtar Aly, Jose Rodriguez, Ehsan Sheybani and Giti Javidi
Biomimetics 2025, 10(6), 379; https://doi.org/10.3390/biomimetics10060379 - 7 Jun 2025
Viewed by 574
Abstract
This paper introduces a novel nature-inspired optimization algorithm called the Grizzly Bear Fat Increase Optimizer (GBFIO). The GBFIO algorithm mimics the natural behavior of grizzly bears as they accumulate body fat in preparation for winter, drawing on their strategies of hunting, fishing, and [...] Read more.
This paper introduces a novel nature-inspired optimization algorithm called the Grizzly Bear Fat Increase Optimizer (GBFIO). The GBFIO algorithm mimics the natural behavior of grizzly bears as they accumulate body fat in preparation for winter, drawing on their strategies of hunting, fishing, and eating grass, honey, etc. Hence, three mathematical steps are modeled and considered in the GBFIO algorithm to solve the optimization problem: (1) finding food sources (e.g., vegetables, fruits, honey, oysters), based on past experiences and olfactory cues; (2) hunting animals and protecting offspring from predators; and (3) fishing. Thirty-one standard benchmark functions and thirty CEC2017 test benchmark functions are applied to evaluate the performance of the GBFIO, such as unimodal, multimodal of high dimensional, fixed dimensional multimodal, and also the rotated and shifted benchmark functions. In addition, four constrained engineering design problems such as tension/compression spring design, welded beam design, pressure vessel design, and speed reducer design problems have been considered to show the efficiency of the proposed GBFIO algorithm in solving constrained problems. The GBFIO can successfully solve diverse kinds of optimization problems, as shown in the results of optimization of objective functions, especially in high dimension objective functions in comparison to other algorithms. Additionally, the performance of the GBFIO algorithm has been compared with the ability and efficiency of other popular optimization algorithms in finding the solutions. In comparison to other optimization algorithms, the GBFIO algorithm offers yields superior or competitive quasi-optimal solutions relative to other well-known optimization algorithms. Full article
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35 pages, 7887 KiB  
Article
Triaxial Experimental Study of Natural Gas Hydrate Sediment Fracturing and Its Initiation Mechanisms: A Simulation Using Large-Scale Ice-Saturated Synthetic Cubic Models
by Kaixiang Shen, Yanjiang Yu, Hao Zhang, Wenwei Xie, Jingan Lu, Jiawei Zhou, Xiaokang Wang and Zizhen Wang
J. Mar. Sci. Eng. 2025, 13(6), 1065; https://doi.org/10.3390/jmse13061065 - 28 May 2025
Viewed by 309
Abstract
The efficient extraction of natural gas from marine natural gas hydrate (NGH) reservoirs is challenging, due to their low permeability, high hydrate saturation, and fine-grained sediments. Hydraulic fracturing has been proven to be a promising technique for improving the permeability of these unconventional [...] Read more.
The efficient extraction of natural gas from marine natural gas hydrate (NGH) reservoirs is challenging, due to their low permeability, high hydrate saturation, and fine-grained sediments. Hydraulic fracturing has been proven to be a promising technique for improving the permeability of these unconventional reservoirs. This study presents a comprehensive triaxial experimental investigation of the fracturing behavior and fracture initiation mechanisms of NGH-bearing sediments, using large-scale ice-saturated synthetic cubic models. The experiments systematically explore the effects of key parameters, including the injection rate, fluid viscosity, ice saturation, perforation patterns, and in situ stress, on fracture propagation and morphology. The results demonstrate that at low fluid viscosities and saturation levels, transverse and torsional fractures dominate, while longitudinal fractures are more prominent at higher viscosities. Increased injection rates enhance fracture propagation, generating more complex fracture patterns, including transverse, torsional, and secondary fractures. A detailed analysis reveals that the perforation design significantly influences the fracture direction, with 90° helical perforations inducing vertical fractures and fixed-plane perforations resulting in transverse fractures. Additionally, a plastic fracture model more accurately predicts fracture initiation pressures compared to traditional elastic models, highlighting a shift from shear to tensile failure modes as hydrate saturation increases. This research provides new insights into the fracture mechanisms of NGH-bearing sediments and offers valuable guidance for optimizing hydraulic fracturing strategies to enhance resource extraction in hydrate reservoirs. Full article
(This article belongs to the Special Issue Advances in Marine Gas Hydrates)
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