Search Results (2,217)

Designing cost-effective, reliable diagnostic sensor suites for complex assets remains challenging due to conflicting objectives across stakeholders. A holistic framework that integrates the Normalised Diagnostic Contribution Index (NDCI)—which scores sensors by separation power, severity sensitivity, and uniqueness—with a Multi-Objective Sensor Optimisation Framework (MOSOF) is presented. Using a high-fidelity virtual aircraft model coupling engine, fuel, electrical power system (EPS), and environmental control system (ECS), NDCI against minimum Redundancy-maximum Relevance (mRMR) is benchmarked under a rigorous nested cross-validation protocol. Across subsystems, NDCI yields more compact suites and higher diagnostic accuracy, notably for engine (88.6% vs. 69.0%) and ECS (67.7% vs. 52.0%). Then, a multi-objective optimisation reflecting an airline use-case (diagnostic performance, cost, reliability, and benefit-to-cost) is executed, identifying a practical Pareto-optimal ‘knee’ solution comprising 12–14 sensors. The recommended suite delivers a normalised performance of ≈0.69 at ≈USD36k with ≈145 kh MTBF, balancing the cross-subsystem information value with implementation constraints. The NDCI-MOSOF workflow provides a transparent, reproducible pathway from raw multi-sensor data to stakeholder-aware design decisions, and constitutes transferable evidence for model-based safety and certification processes in Integrated Vehicle Health Management (IVHM). The limitations (simulation bias, cost/MTBF estimates), validation on rigs or in-service fleets, and extensions to prognostics objectives are discussed. Full article

Background: Amoxicillin, clindamycin and azithromycin are the most frequently prescribed antibiotics for odontogenic infections, but their comparative effects on gut microbiota and intestinal homeostasis remain insufficiently understood. Disruption of gut microbiota, short-chain fatty acid (SCFA) production, and mucosal barrier integrity may contribute to gastrointestinal symptoms. We aimed to compare the impacts of these antibiotics on gut microbiota, SCFA levels, and colonic goblet cells. Methods: C57BL/6N mice were treated with oral amoxicillin, clindamycin, or azithromycin at clinically relevant dosages. Cecal index, fecal water content, and diarrhea index were assessed during treatment and recovery. Gut microbiota composition and absolute bacterial abundance were determined using 16S rRNA amplicon absolute quantification sequencing. SCFAs in cecal contents were quantified by gas chromatography–mass spectrometry. Goblet cell abundance and Muc2 mRNA expression in colon tissues were evaluated using Alcian blue staining and RT-PCR. Results: Amoxicillin caused moderate increases in cecal index, reduced Ligilactobacillus abundance, increased Escherichia-Shigella, lowered SCFA levels, and decreased goblet cells and Muc2 expression, with partial recovery after two weeks. Clindamycin induced more severe dysbiosis, including sustained Proteobacteria expansion, persistent loss of beneficial taxa, 86–90% reduction in SCFA production, and lasting decreases in goblet cells and Muc2 expression without recovery during the observation period. Azithromycin caused mild and reversible changes across all parameters. Conclusions: Among the three antibiotics, azithromycin had the least detrimental effects on gut microbiota, SCFA production, and mucosal barrier function, whereas clindamycin caused profound and persistent intestinal disruption. These findings provide comparative evidence to inform antibiotic selection in clinical practices. Full article

Precision medicine has reshaped the clinical management of prostate cancer by integrating comprehensive genomic profiling, biomarker-driven patient stratification, and the development of molecularly targeted therapeutics. Advances in next-generation sequencing have uncovered diverse genomic alterations—including homologous recombination repair defects, MSI-H/MMRd, PTEN loss, BRCA1/BRCA2 mutations, ATM alterations, SPOP mutations, and molecular hallmarks of neuroendocrine differentiation—that now inform individualized treatment decisions. This review synthesizes established clinical evidence with emerging translational insights to provide an updated and forward-looking overview of precision oncology in prostate cancer. Landmark trials of PARP inhibitors and PSMA-targeted radioligand therapy have redefined treatment standards for biomarker-selected patients. Concurrently, efforts to optimize immune checkpoint inhibition, AKT pathway targeting, and rational combinations with androgen receptor pathway inhibitors continue to expand therapeutic possibilities. Rapidly evolving investigational strategies—including bipolar androgen therapy (BAT), immunotherapeutic approaches for CDK12-altered tumors, targeted interventions for SPOP-mutated cancers, and epigenetic modulation such as EZH2 inhibition for neuroendocrine prostate cancer—further illuminate mechanisms of tumor evolution, lineage plasticity, and treatment resistance. Integrating multi-omics technologies, liquid biopsy platforms, and AI-assisted imaging offers new opportunities for dynamic disease monitoring and biology-driven treatment selection. By consolidating current clinical practices with emerging experimental directions, this review provides clinicians and researchers with a comprehensive perspective on the evolving landscape of precision medicine in prostate cancer and highlights future opportunities to improve patient outcomes. Full article

The rapid proliferation of Electric Vehicle (EV) infrastructures has led to the massive generation of high-frequency streaming data uploaded to cloud platforms for real-time analysis, while such data supports intelligent energy management and behavioral analytics, it also encapsulates sensitive user information, the disclosure or misuse of which can lead to significant privacy and security threats. This work addresses these challenges by developing a secure and scalable scheme for protecting and verifying streaming data during storage and collaborative analysis. The proposed scheme ensures end-to-end confidentiality, forward security, and integrity verification while supporting efficient encrypted aggregation and fine-grained, time-based authorization. It introduces a lightweight mechanism that hierarchically organizes cryptographic keys and ciphertexts over time, enabling privacy-preserving queries without decrypting individual data points. Building on this foundation, an electric vehicle key management and query system is further designed to integrate the proposed encryption and verification scheme into practical V2X environments. The system supports privacy-preserving data sharing, verifiable statistical analytics, and flexible access control across heterogeneous cloud and edge infrastructures. Analytical and experimental evidence show that the designed system attains rigorous security guarantees alongside excellent efficiency and scalability, rendering it ideal for large-scale electric vehicle data protection and analysis tasks. Full article

Investors use information about companies’ social and environmental performance to make investment decisions, a strategy known as Environmental, Social, and Governance (ESG) investment analysis. ESG screening may offer a mechanism to incentivize corporations to improve their health impact. However, there has been limited investigation of the extent to which ESG investment frameworks capture corporate health impacts in major industries. In this study, we sought to characterize the extent to which ESG frameworks address the health-impacting activities of the food and beverage (F&B) industry. To do this, we conducted a deductive framework analysis during the period of September 2023 to March 2024. Specifically, we identified gaps in existing ESG frameworks by comparing the content of five ESG reporting standards and rating systems to the HEALTH-CORP-FB typology, an evidence-based typology that describes the health-impacting activities of the F&B industry across seven domains (Governance Practices, Political Practices, Preference and Perception Shaping Practices, Economic Practices, Employment Practices, Products and Services, and Environmental Practices). To further assess how ESG frameworks account for the health-impacting activities of the F&B industry, we classified health-focused ESG fields in the packaged foods subindustry by two attributes: relevance to the assigned HEALTH-CORP-FB activity (low, medium, high) and type of business operations addressed (e.g., process, performance). Results indicate that, on average, the ESG fields (n = 1348) covered 39% of the 89 HEALTH-CORP-FB activities (range across frameworks: 27–48%). Higher proportions of activities in the Governance, Environmental, Employment, and Economic Practices domains (range across domains: 43–87%) were represented than activities in the Products and Services, Preference and Perception-Shaping Practices, and Political Practices domains (17–36%). Fields assigned to the latter domains were also less likely to be deemed highly relevant and to measure corporate performance. We conclude that the ESG frameworks included in this study capture some of the activities of the F&B industry that affect population health and health equity; however, critical gaps remain. We discuss how integrating key health-focused ESG indicators (e.g., revenue generation from ultra-processed foods) into existing frameworks could enable investors, public health organizations, civil society, and shareholder advocates to strengthen the accountability of the F&B sector with respect to health. Full article

The fresh pet food market has experienced substantial growth, with manufacturers making quality claims that influence consumer purchasing decisions and veterinary recommendations. This systematic review evaluates the scientific evidence supporting three prevalent claims associated with fresh pet food: that additives, preservatives, and fillers are harmful to pet health; that human-grade ingredients provide superior safety and nutrition compared to feed-grade ingredients; and that whole ingredients offer health advantages over processed ingredients. A comprehensive literature search across the SCOPUS, PubMed, and EBSCO databases identified 4888 potential studies. Following systematic screening and quality assessment, 121 studies met inclusion criteria for analysis. Bayesian meta-analyses of additives (n = 60 studies) and preservatives (n = 39 studies) revealed pooled risk differences of 0.0006 and 0.0003, respectively, with Bayes factors strongly supporting null hypotheses of no adverse effects within regulatory limits. Random-effects meta-analyses of processing effects on ingredient digestibility (n = 102 comparisons, SMD = 1.971, p = 0.005) and nutrient content (n = 137 comparisons, SMD = 1.405, p < 0.001) demonstrated significant heterogeneity, with outcomes highly dependent on ingredient type and processing method rather than processing intensity. Human-grade versus feed-grade ingredient comparisons (n = 6 studies) showed methodological limitations and high risk of bias, preventing definitive conclusions. Current evidence does not substantiate claims that approved additives and preservatives cause harm when used within AAFCO guidelines. Processing effects vary substantially by ingredient matrix and method, with both beneficial and detrimental outcomes observed. This review identifies critical research gaps and provides recommendations for evidence-based marketing practices, targeted research priorities, and informed decision-making by industry professionals and consumers. Full article

Background/Objectives: Penile squamous cell carcinoma (PSCC) is rare but aggressive. Systemic chemotherapy plays a crucial role in the management of node-positive or metastatic cases; however, the supporting evidence predominantly originates from small, non-randomized studies. This review provides a narrative analysis of the cytotoxic classes and regimens employed in PSCC and compares major clinical guidelines to facilitate informed decision-making in practice. Methods: English-language reports were identified in PubMed/Scopus/Google Scholar without date limits. Selection prioritized objective response, survival and toxicity outcomes, and guidance statements across neoadjuvant, adjuvant, and palliative settings. Results: Bleomycin-containing triplet regimens demonstrated efficacy but were associated with unacceptable pulmonary toxicity, leading to their discontinuation in clinical recommendations. Currently, cisplatin/taxane-based combinations remain fundamental in treatment protocols. The paclitaxel–ifosfamide–cisplatin (TIP) regimen achieves approximately 40–50% objective responses in phase II studies and may enable curative surgery, while taxane–cisplatin–5-fluorouracil (TPF) shows comparable efficacy with higher toxicity. For less fit patients, cisplatin–5-fluorouracil (PF) or carboplatin–taxane doublets are pragmatic alternatives. Single-agent taxanes or vinflunine offer modest second-line benefits. Although EAU–ASCO 2023, ESMO–EURACAN 2024, and NCCN v2.2025 are broadly in consensus, recommendations differ regarding eligibility thresholds and regimen preferences. Overall, the quality of the evidence remains low. Conclusions: TIP remains the reference neoadjuvant option for chemotherapy-fit patients with bulky nodal disease; doublets are reasonable when cisplatin fitness is limited; and bleomycin should be avoided. Harmonized eligibility criteria, biomarker-enriched studies, and coordinated multicenter trials are needed to improve outcomes in this rare malignancy. Full article

Timely and reliable labor market intelligence is crucial for evidence-based policymaking, workforce planning, and economic forecasting. However, traditional data collection and centralized analytics raise growing concerns about privacy, scalability, and institutional data governance. This paper presents a large language model (LLM)-powered framework for privacy-preserving and scalable labor market analysis, designed to extract, structure, and interpret occupation, skill, and salary information from distributed textual sources. Our framework integrates domain-adapted LLMs with federated learning (FL) and differential privacy (DP) to enable collaborative model training across organizations without exposing sensitive data. The architecture employs secure aggregation and privacy budgets to prevent information leakage during parameter exchange, while maintaining analytical accuracy and interpretability. The system performs multi-task inference—including job classification, skill extraction, and salary estimation—and aligns outputs to standardized taxonomies (e.g., SOC, ISCO, ESCO). Empirical evaluations on both public and semi-private datasets demonstrate that our approach achieves superior performance compared to centralized baselines, while ensuring compliance with privacy and data-sharing regulations. Expert review further confirms that the generated trend analyses are accurate, explainable, and actionable for policy and research. Our results illustrate a practical pathway toward decentralized, privacy-conscious, and large-scale labor market intelligence. Full article

Wearable technologies, such as smartwatches, are increasingly used by people with Chronic Obstructive Pulmonary Disease (COPD) for health monitoring and self-management. However, there is limited evidence-informed guidance available to help patients and healthcare practitioners use these tools effectively in everyday life. Objectives: This study aimed to co-create a digital resource for people with COPD and healthcare practitioners to support the use of smartwatches for self-management. Methods: A participatory co-creation methodology was used, based on the Three Co’s Framework (co-define, co-design, co-refine). Participants included people with COPD, carers, family, or friends of people with COPD; healthcare practitioners; and researchers who attended workshops and individual think-aloud interviews to develop a website and video resource. The resource was refined based on real-time feedback. Data were analysed using rapid qualitative analysis. Results: Twenty-one participants engaged and identified key informational needs, including understanding smartwatch features, interpreting health data, and setting personalised goals. The co-created website and video resource were positively received. Participants valued the inclusion of real-life experiences and practical guidance tailored to both patients and healthcare practitioners. Conclusions: This study presents the first co-created resource for COPD and healthcare practitioners on using smartwatches. The co-creation process was successfully delivered online and face-to-face, demonstrating a robust, inclusive approach to managing multiple stakeholders. The resource offers practical value for patients and practitioners and contributes to the growing field of remote interventions for chronic respiratory conditions. Future research is needed to evaluate its effectiveness. Full article

This scoping review examines public health communication across nine Eastern European and Central Asian states—Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Turkmenistan, and Uzbekistan—highlighting how these systems have transitioned from Soviet-era legacies to contemporary practices. Eligibility criteria included the English- and Russian-language literature published from 1998 onwards, focusing on nine post-Soviet states. Sources of evidence comprised searches in Google Scholar, ScienceDirect, SSRN, Heliyon, MEDLINE/PubMed, and official government websites. Data were charted by three independent reviewers using a standardized form, with discrepancies resolved by senior reviewers. The review identifies persistent gaps in communication during health crises, with a particular focus on the COVID-19 pandemic, where centralized and hierarchical information flows often undermine transparency and responsiveness, as well as further increased health inequalities between rural and urban health outcomes. Despite ongoing reforms, the communication dimension of healthcare systems remains underdeveloped. Findings reveal that centralized and top-down communication remains a dominant feature across the region, hindering timely dissemination of information and limiting the capacity to counter misinformation, as both misinformation and disinformation sometimes emerge from the government. Ultimately, this review contributes a critical analysis of these systematic communication failures and underscores the need to strengthen public health communication and reduce health inequalities. To do it, governments must prioritize transparency, disclose decision-making processes, and rely on evidence-based messaging to build trust. Effective crisis response requires not only government leadership but also the active engagement of the medical and patient communities, supported by civil society and independent media. This review points out the need for more inclusive, transparent, and trust-oriented communication strategies to enhance public health preparedness and resilience in nine Eastern European and Central Asian contexts. Full article

Immersive methods and biometric tools provide a rigorous, context-rich way to study how people perceive and choose food. Immersive methods use extended reality, including virtual, augmented, mixed, and augmented virtual environments, to recreate settings such as homes, shops, and restaurants. They increase participants’ sense of presence and the ecological validity (realism of conditions) of experiments, while still tightly controlling sensory and social cues like lighting, sound, and surroundings. Biometric tools record objective signals linked to attention, emotion, and cognitive load via sensors such as eye-tracking, galvanic skin response (GSR), heart rate (and variability), facial electromyography, electroencephalography, and functional near-infrared spectroscopy. Researchers align stimuli presentation, gaze, and physiology on a common temporal reference and link these data to outcomes like liking, choice, or willingness-to-buy. This approach reveals implicit responses that self-reports may miss, clarifies how changes in context shift perception, and improves predictive power. It enables faster, lower-risk product and packaging development, better-informed labeling and retail design, and more targeted nutrition and health communication. Good practices emphasize careful system calibration, adequate statistical power, participant comfort and safety, robust data protection, and transparent analysis. In food science and consumer behavior, combining immersive environments with biometrics yields valid, reproducible evidence about what captures attention, creates value, and drives food choice. Full article

Background: Optimal nutritional care is essential to improving outcomes in hemodialysis, yet translation of evidence into routine practice remains uneven across settings. To inform health system planning and implementation priorities, we mapped global research on hemodialysis-related nutrition. Methods: We searched the Web of Science Core Collection for English-language original articles on nutrition and hemodialysis from 1 January 2006 to 13 October 2025. Publication trends, productivity by country and institution, influential journals and authors, citation impact, and conceptual structure via Keyword Plus co-occurrence, trend, and thematic evolution analyses were assessed using the bibliometrix package (version 5.0) in R. Results: A total of 332 articles from 115 journals were identified, with substantial growth and multidisciplinary authorship, though international collaboration remains limited. The United States contributed 21.4% of publications and achieved the highest citation impact, while China, Japan, Iran, and Brazil formed the next tier of contributors. The Journal of Renal Nutrition accounted for 16.6% of papers. Highly cited studies established links between dietary intake, mineral and electrolyte management, and survival, while supporting the use of intradialytic oral nutritional supplements. Thematic evolution showed a shift from biochemical markers toward patient-centered priorities, including diet quality, adherence, body composition, mental health, and quality of life. Emerging directions point to whole-diet approaches and microbiome-modulating strategies. Conclusions: Global research on diet and hemodialysis has progressed from foundational nutrient studies to multidimensional, patient-focused approaches. Our findings suggest opportunities for health systems to strengthen dietitian-led models of care, integrate patient-reported outcomes, and prioritize scalable nutrition interventions within routine dialysis services. Full article

Background/Objectives: Tumor biology—particularly HER2 expression, Ki-67 proliferation index, and triple-negative phenotype—has traditionally influenced the timing of breast reconstruction after mastectomy. However, real-world data from Eastern Europe remain limited, and variability in access and clinical practice persists. This study aimed to determine whether tumor biology independently predicts the likelihood of immediate breast reconstruction (IBR) in a multidisciplinary tertiary center. Methods: We performed a retrospective cross-sectional analysis of 208 consecutive patients who underwent mastectomy with or without IBR between January 2023 and January 2024. Associations between tumor biology (HER2 status, Ki-67 index, and triple-negative subtype) and IBR were examined using χ² tests, independent samples t-tests, and multivariate logistic regression adjusting for age, BMI, smoking status, comorbidities, neoadjuvant chemotherapy, pathological tumor size (pT), nodal stage (pN), and surgery type. Statistical significance was set at p < 0.05. Results: IBR was performed in 41.4% of HER2-positive and 41.2% of HER2-negative patients (p = 1.00). Reconstruction rates across Ki-67 quartiles (≤10%, 11–20%, 21–40%, ≥41%) were 50.0%, 37.5%, 34.4%, and 37.5%, respectively (p = 0.58). Triple-negative status was not associated with IBR in multivariate analysis (OR = 0.44, 95% CI 0.08–2.18, p = 0.32). Significant predictors of IBR included younger age (OR = 0.87, 95% CI 0.80–0.93, p < 0.001) and less extensive surgery (OR = 0.23, 95% CI 0.09–0.59, p = 0.002). The mean interval to adjuvant therapy was comparable between IBR (28.7 ± 6.2 days) and non-IBR (27.9 ± 5.8 days) groups (p = 0.34), indicating that reconstruction did not delay systemic treatment. Conclusions: In this real-world Romanian cohort, tumor biology did not significantly influence immediate reconstruction decisions. Age and surgical extent were the main determinants of IBR, suggesting that reconstructive access was guided more by clinical than molecular factors. These findings support the shift toward multidisciplinary, biology-informed, and patient-centered surgical decision-making, in line with current ESMO and NCCN recommendations. Despite limitations—including the retrospective design, single-center setting, incomplete BRCA data, and absence of long-term oncologic outcomes—the study provides novel regional perioperative evidence supporting safe and equitable access to immediate reconstruction across biologic subtypes. Full article

Against the dual backdrop of rapid population aging and legacy neighborhood renewal, morphologically planning-locked legacy neighborhoods in high-density cities face persistent imbalances in outdoor activity spaces that undermine aging-in-place participation and health equity. This study advances a Spatial Pathology framework. Using nine representative communities in Longtan Subdistrict, Dongcheng District, Beijing, we develop a GIS-assisted spatial audit, a systematic behavioral observation protocol with temporal-intensity metrics, and a validated perception instrument. These tools form a closed evidentiary loop with explicit indicator definitions, formulas, and decision thresholds, alongside a reproducible analytic and visualization pipeline. Tri-dimensional baselines revealed substantial inter-community disparities: Spatial Quality Index (SQI) ranged from 43.3 to 77.0; activity intensity varied from 1.5 to 15.7 persons/100 m²·hour; and overall satisfaction scores spanned 3.88–4.49. It quantifies and identifies three core paradoxes in outdoor activity spaces within this context: (1) the Functional Failure Paradox with FFI exceeding +0.5 and ELR surpassing 60% in dormant communities; (2) the Value Misalignment Paradox where Facilities & Equipment showed the strongest satisfaction impact (β = 0.344) yet the largest unmet-need gap (VQGI > +8); (3) the Practice–Perception Decoupling Paradox evidenced by a negative correlation (r = −0.38) between usage intensity and satisfaction. These paradoxes reveal the spatial roots of planning-locked legacy neighborhoods—compound mechanisms of planning inertia, decision–demand information gaps, and elderly adaptability masking environmental deficits. We translate the diagnosis into typology-specific prescriptions—reactivating dormant spaces via “route–node–plane” continuity and proximal micro-spaces; decongesting peak periods through elastic zoning and equipment redistribution; and precision calibration of facilities and walking loops—implemented through co-creation and light-touch stewardship. This provides evidence-based, precision-targeted intervention pathways for micro-renewal of aging neighborhoods, supporting localized implementation of UN Sustainable Development Goals (SDG 11 Sustainable Cities; SDG 10 Reduced Inequalities). This methodological framework is transferable to other high-density aging cities, offering theoretical scaffolding and empirical reference for multi-source geographic data-driven urban spatial analysis and equity-oriented age-friendly retrofitting. Full article

The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT) was launched in 2025 to address urgent gaps in supportive care for Canadians with cancer experiencing demoralization syndrome (loss of meaning, dysphoria, disheartenment, helplessness, a sense of failure) and related psychosocial distress. CAN-PACT has six major objectives: (1) to develop a national interdisciplinary research and practice network; (2) to set research priorities through structured stakeholder engagement; (3) to develop and provide PAT training and education for clinicians, researchers, and patients; (4) to pilot test the feasibility of intervention and assessment procedures; (5) to conduct a multi-center, randomized controlled trial of PAT for people with advanced cancer; and (6) to inform and influence healthcare policy on PAT in Canada. We discuss the background and need for PAT in cancer, describe challenges currently limiting its use, and outline CAN-PACT’s strategy for building capacity, generating Canadian evidence, and preparing the oncology healthcare environment for potential implementation. This manuscript presents a summary overview of CAN-PACT as a multi-objective research program; detailed protocols for each discrete study component will be published separately as the research program progresses. Through environmental scans, national engagement, targeted training, rigorous research, and ongoing collaboration with policymakers, CAN-PACT aims to enable equitable access to safe, evidence-based PAT for people with advanced cancer in Canada’s publicly funded cancer centers. Full article