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21 pages, 822 KB  
Article
Global Market Shocks and Food Riots: The Impact of Energy Prices, Biofuels, and Financial Speculation in Africa
by Tetsuji Tanaka and Jin Guo
Sustainability 2026, 18(6), 2959; https://doi.org/10.3390/su18062959 - 17 Mar 2026
Abstract
Even though the existing literature has elucidated the domestic causes of riots and the links between global food prices and riots, the relationship between riots and various external factors, such as biofuel production, global crude oil prices, speculation, and the US dollar exchange [...] Read more.
Even though the existing literature has elucidated the domestic causes of riots and the links between global food prices and riots, the relationship between riots and various external factors, such as biofuel production, global crude oil prices, speculation, and the US dollar exchange rate, has yet to be fully analyzed. This study aimed to fill this research gap by examining the associations of these external factors on the occurrence of riots in Africa using the Poisson, negative binomial, and zero-inflated negative binomial models. Our key findings are as follows: (1) U.S. ethanol production and international crude oil prices are positively associated with riot frequency, whereas U.S. biodiesel production is not statistically significant. (2) A higher long share relative to open interest increases riot incidence, while a higher short share reduces it. (3) Both international food prices and African domestic food prices exhibit positive and statistically significant associations with riots. (4) Appreciation of the U.S. dollar is negatively correlated with food riots. Overall, the findings suggest that global energy, financial, monetary, and food price dynamics are systematically linked to food riots in Africa. Full article
(This article belongs to the Special Issue Sustainable Development and Climate, Energy, and Food Security Nexus)
35 pages, 4866 KB  
Article
Today’s Water Meters (Mechanical) Can Sometimes Greatly Overestimate Domestic Consumption Due to Air in Pipelines: A Field Evidence
by Serge Tamari and Víctor Arroyo-Correa
Water 2026, 18(6), 704; https://doi.org/10.3390/w18060704 - 17 Mar 2026
Abstract
Nowadays, most water meters are mechanical and intended to be installed on pipes completely filled with water. But the pipelines of a water supply network may contain air, which poses a metrological problem: if this air flows through the domestic intakes, it can [...] Read more.
Nowadays, most water meters are mechanical and intended to be installed on pipes completely filled with water. But the pipelines of a water supply network may contain air, which poses a metrological problem: if this air flows through the domestic intakes, it can propel the moving part of the meters, resulting in an overestimation of water consumption. By how much? There is a surprising lack of field data on this topic. So, the case of one house is reported: it is located at the top of a steep and sparsely occupied street, with water typically supplied for a few hours per day. The house’s meter (multi-jet) was estimating a huge and erratic consumption: several times more than what would be normally expected on average, and with some daily peaks exceeding the built storage capacity (underground cistern plus roof tank). After one year of monitoring, including the installation of a few devices, it is concluded that: (1) the house’s meter was affected by air in the water supply network (most likely for different reasons, of which three are discussed); (2) a small air-release valve installed just upstream from the meter did not solve the problem; (3) another mechanical meter (single-jet) installed just downstream was also affected by air (although to a lesser extent), and (4) reliable estimates of water consumption were finally obtained with an ultrasonic meter installed at the domestic intake (and with a mechanical meter installed at the roof tank’s outlet). Thus, the case reported emphasizes the need to study more how air in pipelines affects mechanical water meters and to sometimes consider alternatives for measuring domestic water consumption. Full article
(This article belongs to the Section Urban Water Management)
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32 pages, 2479 KB  
Review
Hygrothermal and Climatic Energy Retrofit Strategies for Net-Zero Buildings: Performance Impacts and Occupant Health
by Muhammad Kashif, Saif Ul Haq, Musaddaq Azeem and Hafiz Muhammad Asad Ali
Sustainability 2026, 18(6), 2950; https://doi.org/10.3390/su18062950 - 17 Mar 2026
Abstract
The high energy consumption in the building sector and the increasing impacts of climate change have necessitated the transition to net-zero-energy buildings (NZEBs), in which energy retrofit strategies play a key role. However, neglecting moisture transport and climatic design while improving energy efficiency [...] Read more.
The high energy consumption in the building sector and the increasing impacts of climate change have necessitated the transition to net-zero-energy buildings (NZEBs), in which energy retrofit strategies play a key role. However, neglecting moisture transport and climatic design while improving energy efficiency often leads to reduced building performance, material deterioration, worse occupant health, and indoor environmental problems. This review examines in detail the basic mechanisms of moisture transport, including diffusion, capillary action, and airborne moisture transport, and illustrates how poor moisture control affects thermal performance and resident health. Additionally, a comparative analysis of the impact of retrofit strategies implemented in different climatic regions on energy efficiency, carbon emission reduction, moisture-related failures and net-zero goals is conducted. At the same time, the need exists to incorporate awareness regarding the adverse effects on the health of occupants. This systematic review analyzed 120 peer-reviewed studies published from 1994 to 2026, covering different climatic regions (e.g., cold, temperate, warm–humid, etc.). The analysis found that the energy savings rates were reported to range from 18% to 45%, while the moisture-related failures in inappropriately retrofitted buildings were observed to increase by up to 32% in some cold regions. This research review provides a comprehensive advisory framework for domestic residents to take remedial steps until retrofit experts gain access in order to prevent health risks from mold and moisture ingress, which can contribute to a healthy lifestyle and a net-zero-energy building. Full article
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25 pages, 5502 KB  
Systematic Review
A Systematic Review of the Trajectory of Urban Resilience Research: A Bibliometric Perspective on Global Trends and China’s Pathway
by Meng Han, Gui Fu, Zhirong Wu, Yuxuan Lu, Xuecai Xie and Surui Xu
Sustainability 2026, 18(6), 2945; https://doi.org/10.3390/su18062945 - 17 Mar 2026
Abstract
This study employs bibliometric analysis, utilizing the visualization tools CiteSpace 6.3.R1 and VOSviewer 1.6.18, to systematically examine 8727 documents from the Web of Science Core Collection (2000–2024) related to “resilient cities” and “urban resilience.” It explores the evolution of resilient city research, current [...] Read more.
This study employs bibliometric analysis, utilizing the visualization tools CiteSpace 6.3.R1 and VOSviewer 1.6.18, to systematically examine 8727 documents from the Web of Science Core Collection (2000–2024) related to “resilient cities” and “urban resilience.” It explores the evolution of resilient city research, current international trends, practical developments in China, and future directions. The study addresses key questions concerning the theoretical foundations of resilient cities, research advances in the security field, China’s implementation pathways, and emerging trends. Findings indicate that resilient city discourse has evolved from a narrow focus on engineering-based disaster prevention toward a multidimensional, socio-ecological–economic adaptive system. This progression can be divided into three phases: the theoretical foundation period (2000–2008), the technological integration period (2009–2018), and the complex crisis response period (2019–present). Internationally, practices are increasingly centered on climate change adaptation, supported by multi-level governance frameworks such as the MCR2030 initiative. China demonstrates a “dual-track” approach that combines policy-driven initiatives with localized innovations, advancing through international pilot projects, domestic policy experimentation, and grassroots exploration. The study also highlights differences between Chinese and Western research in perspectives, methodologies, and theoretical frameworks. Future resilient city development is expected to emphasize systematization, digitalization, and equity, leveraging technologies such as digital twins and artificial intelligence while fostering community participation and multi-scale collaborative governance. By systematically outlining the theoretical evolution and practical logic of resilient cities, this study offers insights for urban resilience building in developing countries and provides a methodological reference for enhancing resilience capabilities across different administrative levels. Full article
(This article belongs to the Special Issue Environmental Planning and Governance for Sustainable Cities)
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16 pages, 1981 KB  
Article
Genomic Insights into Ciprofloxacin-Resistant Enteropathogenic Escherichia coli ST752 in Republic of Korea: A One Health Perspective on Its Emergence and Transmission
by Yeongeun Seo, Wooju Kang, Eunkyung Shin, Jungsun Park, Mooneui Hong, Dong-Hyun Roh and Junyoung Kim
Antibiotics 2026, 15(3), 304; https://doi.org/10.3390/antibiotics15030304 - 17 Mar 2026
Abstract
Background/Objectives: We analyzed the whole-genome sequences of ciprofloxacin-resistant (CIP-R) enteropathogenic Escherichia coli (EPEC) ST752 isolates in South Korea to characterize their molecular epidemiology. This lineage has emerged as the predominant CIP-R EPEC clone in South Korea, accounting for 28.8% of human clinical [...] Read more.
Background/Objectives: We analyzed the whole-genome sequences of ciprofloxacin-resistant (CIP-R) enteropathogenic Escherichia coli (EPEC) ST752 isolates in South Korea to characterize their molecular epidemiology. This lineage has emerged as the predominant CIP-R EPEC clone in South Korea, accounting for 28.8% of human clinical isolates and circulating within the One Health interface. Methods: We performed whole-genome sequencing (WGS) and reference-based core-genome single-nucleotide polymorphism (SNP) analysis on 26 CIP-R EPEC ST752 isolates (19 human clinical and 7 poultry-derived isolates). To elucidate their evolutionary history and transmission dynamics, Bayesian phylodynamic and phylogeographic reconstructions were implemented by integrating domestic isolates with a global genome dataset (n = 508). Results: Isolates from human and poultry sources clustered together with an identical virulence profile and minimal genetic distance. The Bayesian molecular clock analysis estimated that the time to the most recent common ancestor of the South Korean clade was 2000.65. Moreover, the phylogeographic analysis supported statistical evidence (Bayes factor 32.16) for the introduction of this lineage into South Korea from Denmark and revealed a strongly supported host transition from humans to poultry (Bayes factor > 10,000), although this requires cautious interpretation due to limited temporal sampling of poultry isolates. Conclusions: Continued integrated One Health surveillance across human, animal, and environmental reservoirs is needed to monitor and prevent the spread of high-risk antimicrobial-resistant clones. Full article
(This article belongs to the Section Antibiotics Use and Antimicrobial Stewardship)
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22 pages, 1425 KB  
Article
Structural Optimization of a Mechanical Lime Kiln Using Multi-Physics Coupling Simulation to Improve Calcination Uniformity
by Jing Yang, Zhenpeng Li, Yunfan Lu, Kangchun Li and Fuchuan Huang
Appl. Sci. 2026, 16(6), 2885; https://doi.org/10.3390/app16062885 - 17 Mar 2026
Abstract
The present study deals with the problem of irregular temperature distribution, simultaneous under-firing and over-firing, and their resultant efficiency and quality problems in a mechanical lime vertical kiln powered by domestic waste flue gas. The numerical simulation and structure optimization were carried out [...] Read more.
The present study deals with the problem of irregular temperature distribution, simultaneous under-firing and over-firing, and their resultant efficiency and quality problems in a mechanical lime vertical kiln powered by domestic waste flue gas. The numerical simulation and structure optimization were carried out based on a 150 kg/h pilot-scale kiln. This combined model was built on the ANSYS Fluent 2022 R1 platform with UDF and UDS, incorporating limestone decomposition kinetics to enable the solution of gas and solid energy equations separately, and simulation of complex transfer and reaction processes. To correct the separation of flows at one inlet, a symmetric four-direction (00, 900, 1800, 2700) air intake plan was suggested. The findings show that this design essentially transforms the internal flow field into uniform and symmetrical temperature and concentration distributions. The calcination region contained both gas and solid temperatures in the optimum range to produce active lime. Specifically, the optimized kiln achieved a temperature range of 1190–1450 K in the calcination zone, a decomposition rate of approximately 82.7% (compared to 5.3% in the original model), and an increase in effective CaO content from 81.7% to 87.7%, with validation errors below 15%. It was demonstrated that the model is reliable, since the outlet simulated values correlated well with the measured ones. The preheating, calcining, and cooling zones’ heights of the optimized kiln adhered to the design requirements. This research is innovative in its application of a multi-physics coupling model with a varying heat source in a kiln and, in turn, identifies the synergism improvement process in the flow, temperature, concentration, and reaction fields. Full article
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37 pages, 4547 KB  
Review
Functionalization of Textile Materials for Advanced Engineering Applications
by Andrey A. Vodyashkin, Mstislav O. Makeev, Dmitriy S. Ryzhenko and Anastasia M. Stoynova
Int. J. Mol. Sci. 2026, 27(6), 2708; https://doi.org/10.3390/ijms27062708 - 16 Mar 2026
Abstract
Textile materials represent a versatile class of engineering substrates widely used in apparel, domestic products, and medical protective systems. Despite their extensive application, large-scale textile production has seen limited integration of fundamentally new functionalization strategies. In recent years, however, advances in materials science [...] Read more.
Textile materials represent a versatile class of engineering substrates widely used in apparel, domestic products, and medical protective systems. Despite their extensive application, large-scale textile production has seen limited integration of fundamentally new functionalization strategies. In recent years, however, advances in materials science have enabled the development of textiles with tailored electrical, adaptive, and biological functionalities. This review summarizes recent progress in the functionalization of textile materials with a focus on approaches relevant to engineering and industrial implementation. Particular attention is given to conductive textiles designed for operation under extreme environmental conditions, including low-temperature climates. Methods for integrating electrically conductive elements into fibrous structures are discussed, highlighting their potential for sensing, thermal regulation, and energy-related applications such as powering portable electronic devices. Inkjet printing is presented as a scalable technique for high-resolution deposition of conductive patterns while preserving the mechanical integrity and aesthetic properties of textile substrates. In addition, adaptive and stimuli-responsive textile systems are reviewed, including materials capable of responding to thermal, optical, or chemical stimuli, with applications in camouflage, wearable systems, and multifunctional surfaces. The review further addresses the development of bioactive textiles, emphasizing antibacterial functionalization using organic and inorganic agents to mitigate the spread of pathogenic microorganisms. The relevance of such materials has been underscored by recent global viral outbreaks. Overall, this work aims to provide a materials science perspective on emerging textile functionalization strategies and to facilitate the transition of these technologies from laboratory-scale research to practical engineering applications. Full article
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22 pages, 3821 KB  
Article
A Simplified Model of a Solar Water Heating System with Phase Change Materials in the Storage Tank
by Barbara Król and Krzysztof Kupiec
Buildings 2026, 16(6), 1172; https://doi.org/10.3390/buildings16061172 - 16 Mar 2026
Abstract
The intermittent and variable nature of solar energy poses challenges for maintaining stable thermal performance in solar heating systems. One effective approach to mitigate this limitation is to store surplus thermal energy during periods of high solar irradiance and release it when solar [...] Read more.
The intermittent and variable nature of solar energy poses challenges for maintaining stable thermal performance in solar heating systems. One effective approach to mitigate this limitation is to store surplus thermal energy during periods of high solar irradiance and release it when solar input is insufficient. Phase change materials (PCMs) are particularly suitable for this purpose due to their ability to absorb and release large amounts of latent heat during phase transition. The aim of this work is to develop a mathematical model of a flow-through tank containing a phase change material in the form of a spherical packed bed. Including longitudinal dispersion in the model equations allows for a more accurate description of the heat transfer process in a tank containing PCM elements. Simulation calculations based on the model were carried out to demonstrate its potential applicability to practical problems. The influence of the following parameters on the process was investigated: tank volume, water flow rate, phase change temperature, process duration, dispersion coefficient during water flow, radius of the packed-bed elements, and cyclic variations of the inlet water temperature. A significant influence of the axial dispersion coefficient in the tank containing PCM on the outlet water temperature profile was demonstrated. It was found that the internal heat transfer coefficient within the packing elements containing PCM falls within the range of 58–145 W/(m2K). Full article
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21 pages, 766 KB  
Article
From Private Trouble to Collective Concern: A Corpus-Based Analysis of Intimate Partner Violence in China News Media
by Shuai Liu, Fang Geng and Zi Yang
Soc. Sci. 2026, 15(3), 190; https://doi.org/10.3390/socsci15030190 - 16 Mar 2026
Abstract
Intimate partner violence (IPV) remains understudied in China despite its public health significance. Previous research lacks comprehensive analysis of how Chinese media frames this issue, creating a gap in understanding the sociocultural factors shaping public discourse. This study employs corpus-based framing analysis of [...] Read more.
Intimate partner violence (IPV) remains understudied in China despite its public health significance. Previous research lacks comprehensive analysis of how Chinese media frames this issue, creating a gap in understanding the sociocultural factors shaping public discourse. This study employs corpus-based framing analysis of 603 news articles (435,581 words) from major Chinese newspapers spanning 2012–2022, a period encompassing significant legal developments including the 2016 Domestic Violence Law. We analyze how IPV is framed through examination of keyword frequencies, collocation patterns, and concordance analysis. Our findings reveal that IPV is predominantly framed as matrimonial conflict and family dispute rather than criminal violence requiring state intervention. We argue that framing IPV as a ‘family issue’ operates as a spatial containment strategy, relocating violence to the domestic sphere while rerouting intervention into administrative/civil channels rather than criminal accountability spaces. Our findings reveal significant imbalances in stakeholder representation, with government and legal voices dominating the public discourse domain while community support organizations are marginalized. Source attribution patterns produce uneven zones of legitimacy, where state actors occupy authorized public space while survivors’ experiences remain confined to private, silenced domains. This research enhances the understanding of IPV media coverage in China while highlighting the need for more inclusive public discourse. Full article
(This article belongs to the Special Issue Zones of Violence: Mediating Gender, Power, and Place)
28 pages, 3433 KB  
Article
Techno-Economic Optimization of an Integrated Renewable-Hydrogen-Data Center Hub for Yanbu Industrial City in Saudi Arabia
by Abdulaziz A. Alturki
Energies 2026, 19(6), 1482; https://doi.org/10.3390/en19061482 - 16 Mar 2026
Abstract
Global data center electricity demand is projected to double to 945 TWh by 2030, yet no optimization framework jointly sizes renewable generation, battery storage, hydrogen export infrastructure, and flexible computing loads within a single industrial hub. This paper develops a two-layer techno-economic workflow [...] Read more.
Global data center electricity demand is projected to double to 945 TWh by 2030, yet no optimization framework jointly sizes renewable generation, battery storage, hydrogen export infrastructure, and flexible computing loads within a single industrial hub. This paper develops a two-layer techno-economic workflow for an integrated renewable–hydrogen–data center hub in Yanbu Industrial City, Saudi Arabia. HOMER Pro provides baseline capacity sizing and dispatch across four scenarios; a Pyomo-based mixed-integer linear program, calibrated to within 2% of the baseline, then extends the system to include a 60 MW data center (30 MW critical, 30 MW flexible), multi-sink hydrogen allocation (domestic, ammonia, methanol), and low-grade waste heat recovery. Battery storage emerges as the dominant cost–carbon lever: its removal raises the levelized cost of electricity (LCOE) from 0.052 to 0.181 USD/kWh (+250%) and increases CO2 emissions from 1.83 to 2763 kt/yr, a factor of 1510. The Integrated Hub reduces annualized costs by 8.2% (36.9 M USD/yr) and emissions by 28% relative to a separate-build counterfactual, driven by shared PV–battery infrastructure and hydrogen export revenues of 58.5 M USD/yr. Export demand raises the electrolyzer capacity factor from 8.65% to 24.3%, cutting the levelized cost of hydrogen from 10.5 to 6.8 USD/kg. Waste heat recovery reduces the levelized cost of heat by 17%, and co-location lowers the levelized cost of compute by 23% (from 0.055 to 0.042 USD/GPU/hr). These results provide quantitative design principles for industrial hub planners considering data center co-location in high-solar regions with hydrogen export ambitions. Full article
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17 pages, 9521 KB  
Article
Pan-Genome Analysis of the Fructokinase Gene Family Reveals a Light-Regulated SiPhyC–SiFRK4 Module Controlling Carbon Partitioning in Foxtail Millet
by Lu He, Juan Zhao, Guangxin Wang, Ling Yuan, Xingchun Wang and Zhirong Yang
Plants 2026, 15(6), 907; https://doi.org/10.3390/plants15060907 - 15 Mar 2026
Abstract
Fructokinase (FRK) initiates fructose phosphorylation, channeling carbon into central metabolic pathways, yet its functional diversity and regulatory networks in C4 cereals remain poorly understood. Here, we performed a comprehensive pan-genome analysis of the FRK gene family in foxtail millet (Setaria italica [...] Read more.
Fructokinase (FRK) initiates fructose phosphorylation, channeling carbon into central metabolic pathways, yet its functional diversity and regulatory networks in C4 cereals remain poorly understood. Here, we performed a comprehensive pan-genome analysis of the FRK gene family in foxtail millet (Setaria italica), identifying 697 SiFRKs across 110 accessions and revealing extensive presence–absence variation shaped by evolution and domestication. Among nine characterized members in the reference genome, SiFRK4 exhibited broad and high expression, a diurnal rhythm, and substantial natural variation. Biochemical assays confirmed its fructokinase activity in vitro. We discovered a novel physical interaction between SiFRK4 and the key photoreceptor Phytochrome C (SiPhyC), which co-localized in the cytoplasm. Functional analysis of SiPhyC mutants demonstrated that loss of SiPhyC disrupted carbohydrate homeostasis, elevating fructose while depleting sucrose and starch. Our findings reveal a physical and genetic link between the light-signaling component SiPhyC and the metabolic enzyme SiFRK4, suggesting their interaction influences carbon partitioning. This study provides foundational insights into the sugar metabolism network of a resilient C4 model crop and identifies potential targets for metabolic engineering and breeding. Full article
(This article belongs to the Section Plant Genetics, Genomics and Biotechnology)
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13 pages, 2088 KB  
Article
Insights into Nuclear Mitochondrial Sequence Distribution in the Pig Genome Based on the Latest Reference Assembly
by Hongtao Li, Cheng Yang, Guiming Zhu, Qin Zhang, Chao Ning and Dan Wang
Animals 2026, 16(6), 919; https://doi.org/10.3390/ani16060919 - 14 Mar 2026
Abstract
Horizontal transfer of mitochondrial DNA into the nuclear genome generates nuclear mitochondrial sequences (NUMTs), which serve as molecular fossils reflecting long-term mitochondrial–nuclear interactions and genome evolution. However, the biological mechanisms governing NUMT integration, retention, and evolutionary fate remain incompletely understood in domesticated animals. [...] Read more.
Horizontal transfer of mitochondrial DNA into the nuclear genome generates nuclear mitochondrial sequences (NUMTs), which serve as molecular fossils reflecting long-term mitochondrial–nuclear interactions and genome evolution. However, the biological mechanisms governing NUMT integration, retention, and evolutionary fate remain incompletely understood in domesticated animals. Here, using the latest pig reference genome assembly (Sscrofa11.1), we present a comprehensive genome-wide characterization of NUMTs in pigs and provide new insights into their genomic distribution and evolutionary constraints. We identified 513 high-confidence NUMTs, of which 460 were chromosomally mapped, accounting for 0.0106% of the nuclear genome. Beyond increased detection, our analyses reveal that pig NUMTs exhibit non-random origins, preferentially integrate into genomic regions under weak selective constraint, and are frequently associated with repetitive elements, consistent with a DNA repair-mediated insertion mechanism. NUMTs predominantly occur as short, fragmented sequences and show signatures of long-term neutral evolution, while insertions disrupting coding sequences are strongly selected against. Synteny-based analyses further identified clustered NUMT regions and duplicated NUMTs, suggesting secondary genomic duplication events following initial integration. Comparative analysis with the earlier Sscrofa10.2 assembly demonstrates that improved genome quality substantially enhances NUMT detection, particularly in repetitive and GC-rich regions, clarifying previously ambiguous sequence-context associations. Together, this high-quality pig NUMT map provides a robust foundation for future functional, evolutionary, and population-level investigations and contributes to the conservation and utilization of pig genetic resources. Full article
(This article belongs to the Section Pigs)
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20 pages, 1292 KB  
Article
Institutional Conditions for Digital Innovation and Transformation: A Contingent Framework for Smart Technology Adoption in Developing Nations
by Ibrahim Ejdayid Ajbarah Mansour and Abdelhamid Bouchachia
Sustainability 2026, 18(6), 2868; https://doi.org/10.3390/su18062868 - 14 Mar 2026
Abstract
This paper addresses the persistent failure of major digital investments to achieve sustained smart technology adoption in developing countries, limiting productivity and business growth. Although existing research identifies institutional weaknesses as a central barrier, it provides limited guidance on how progress can occur [...] Read more.
This paper addresses the persistent failure of major digital investments to achieve sustained smart technology adoption in developing countries, limiting productivity and business growth. Although existing research identifies institutional weaknesses as a central barrier, it provides limited guidance on how progress can occur within such constraints. To address this gap, the Institutional Framework for Smart Technology Adoption (IFSTA), pronounced Eye-f-sta, is developed as a contingent institutional framework linking digital transformation theory with practical assessment tools. IFSTA argues that adoption success depends not on technology alone, but on strategic alignment with specific institutional contexts. The framework is built around three core pillars, governance architecture, socio-technical infrastructure, and adaptive capacity, and explains how their interactions generate differentiated adoption outcomes across five institutional contexts. Localization is conceptualized as a cross-cutting mediating mechanism through which governance arrangements, standards, platforms, and capabilities are adapted to domestic realities, shaping both current performance and future transformation potential. Three questions guide the analysis: how institutional contexts moderate the impact of infrastructure investment; what complementarities and compensatory mechanisms enable progress under institutional constraints; and how digital investments can be sequenced according to institutional starting points. To operationalize this logic, the Performance–Knowledge Index (PKI) is introduced as a context-sensitive diagnostic tool that identifies binding constraints and supports sequenced intervention design. The study contributes a contingent institutional model, a methodological bridge between diagnosis and implementation, and a structured, actionable framework for advancing sustainable digital adoption in developing economies. Full article
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38 pages, 2636 KB  
Review
The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors
by Slovénie Pyndiah
Int. J. Mol. Sci. 2026, 27(6), 2662; https://doi.org/10.3390/ijms27062662 - 14 Mar 2026
Abstract
Cellular survival and adaptability depend on the dynamic regulation of proteins—the central actors of biological systems. Through mechanisms such as post-translational modifications, protein turnover, and the formation of membraneless organelles, cells can sense and respond to a variety of stressors. Recent advances in [...] Read more.
Cellular survival and adaptability depend on the dynamic regulation of proteins—the central actors of biological systems. Through mechanisms such as post-translational modifications, protein turnover, and the formation of membraneless organelles, cells can sense and respond to a variety of stressors. Recent advances in artificial intelligence and chemical biology have provided powerful tools to study and manipulate these processes, paving the way for novel therapeutic strategies in cancer. This review explores how cells “tame” their proteome in response to stress by coordinating protein synthesis, modification, degradation, and structural organization to maintain functional resilience. Full article
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59 pages, 7331 KB  
Review
Human–Robot Interaction in Indoor Mobile Robotics: Current State, Interaction Modalities, Applications, and Future Challenges
by Arman Ahmed Khan and Kerstin Thurow
Sensors 2026, 26(6), 1840; https://doi.org/10.3390/s26061840 - 14 Mar 2026
Abstract
This paper provides a comprehensive survey of Human–Robot Interaction (HRI) for indoor mobile robots operating in human-centered environments such as hospitals, laboratories, offices, and homes. We review interaction modalities—including speech, gesture, touch, visual, and multimodal interfaces—and examine key user experience factors such as [...] Read more.
This paper provides a comprehensive survey of Human–Robot Interaction (HRI) for indoor mobile robots operating in human-centered environments such as hospitals, laboratories, offices, and homes. We review interaction modalities—including speech, gesture, touch, visual, and multimodal interfaces—and examine key user experience factors such as usability, trust, and social acceptance. Implementation challenges are discussed, encompassing safety, privacy, and regulatory considerations. Representative case studies, including healthcare and domestic platforms, highlight design trade-offs and integration lessons. We identify critical technical challenges, including robust perception, reliable multimodal fusion, navigation in dynamic spaces, and constraints on computation and power. Finally, we outline future directions, including embodied AI, adaptive context-aware interactions, and standards for safety and data protection. This survey aims to guide the development of indoor mobile robots capable of collaborating with humans naturally, safely, and effectively. Full article
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