Search Results (128)

Post-viral conditions, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC), share > 95% of their symptoms, but the connection between disturbances in their underlying molecular biology is unclear. This study investigates DNA methylation patterns in peripheral blood mononuclear cells (PBMC) from patients with ME/CFS, LC, and healthy controls (HC). Reduced Representation Bisulphite Sequencing (RRBS) was applied to the DNA of age- and sex-matched cohorts: ME/CFS (n = 5), LC (n = 5), and HC (n = 5). The global DNA methylomes of the three cohorts were similar and spread equally across all chromosomes, except the sex chromosomes, but there were distinct minor changes in the exons of the disease cohorts towards more hypermethylation. A principal component analysis (PCA) analysing significant methylation changes (p < 0.05) separated the ME/CFS, LC, and HC cohorts into three distinct clusters. Analysis with a limit of >10% methylation difference and at p < 0.05 identified 214 Differentially Methylated Fragments (DMF) in ME/CFS, and 429 in LC compared to HC. Of these, 118 DMFs were common to both cohorts. Those in promoters and exons were mainly hypermethylated, with a minority hypomethylated. There were rarer examples with either no change in methylation in ME/CFS but a change in LC, or a methylation change in ME/CFS but in the opposite direction in LC. The differential methylation in a number of fragments was significantly greater in the LC cohort than in the ME/CFS cohort. Our data reveal a generally shared epigenetic makeup between ME/CFS and LC but with specific, distinct changes. Differences between the two cohorts likely reflect the stage of the disease from onset (LC 1 year vs. ME/CFS 12 years), but specific changes imposed by the SARS-CoV-2 virus in the case of the LC patients cannot be discounted. These findings provide a foundation for further studies with larger cohorts at the same disease stage and for functional analyses to establish clinical relevance. Full article

This study examines how contract structures influence coordination and innovation incentives in dual-channel telecommunications supply chains. We consider a setting where a mobile network operator (MNO) supplies services both directly to consumers and indirectly through a mobile virtual network operator (MVNO), which competes in the retail market. Using a game-theoretic framework, we evaluate how different contracts—single wholesale pricing, revenue sharing, and quantity discounts—shape strategic decisions, particularly in the presence of investment spillovers between parties. A key coordination problem emerges from the externalized gains of innovation, where one party’s investment generates value for both participants. Our results show that single wholesale and revenue sharing contracts often lead to suboptimal investment and profit outcomes. In contrast, quantity discount contracts, especially when combined with appropriate transfer payments, improve coordination and enhance the total performance of the supply chain. We also find that innovation led by the MVNO, while generally less impactful, can still yield reciprocal benefits for the MNO, reinforcing the value of cooperative arrangements. These findings emphasize the importance of contract design in managing interdependence and improving efficiency in decentralized supply chains. This study offers theoretical and practical implications for telecommunications providers and policymakers aiming to promote innovation and mutually beneficial outcomes through well-aligned contractual mechanisms. Full article

This study conducts a techno-economic evaluation of an all-electric energy station in China. It assesses the system’s feasibility and sustainability. The all-electric energy station integrates multiple components: chillers, air-source heat pumps, electric boilers, water thermal storage, and gas boilers. These components work together to deliver comprehensive cooling and heating services. The research compares this system with an integrated electricity-gas system. It analyzes performance across three key areas: economic benefits, environmental impact, and energy utilization efficiency. The results show significant advantages for the all-electric energy station. Economic analysis reveals that the net present value (NPV) of the all-electric energy station is positive, the internal rate of return (IRR) is high, and the payback period is significantly shorter compared to traditional systems. Sensitivity analysis highlights that the discount rate and initial investment are the most influential factors affecting NPV, while cooling prices present substantial revenue optimization potential. The all-electric configuration exhibits greater sensitivity to parameter variations, underscoring the importance of strategic risk management. Additionally, the all-electric energy station excels in environmental protection. Carbon emissions are reduced by 11.5% compared to conventional systems. As renewable energy increases in the grid, indirect carbon emissions will decrease further. The all-electric energy station demonstrates strong economic feasibility. It plays a crucial role in achieving carbon neutrality and promoting green energy development. This study provides valuable insights for future regional integrated energy systems. Full article

The public–private partnerships (PPP) mode is very popular in public infrastructure projects. The PPP model for sponge city construction (SCC) provides an effective way to curb and manage the increasingly serious ecological water problems in China. The quantitative evaluation of value for money (VFM) is an evaluation method that obtains quantitative values through a certain calculation process. However, the current studies lack a dynamic quantitative evaluation of VFM for the entire life cycle of SCC PPP projects, and cannot observe the impact of key factors on the VFM value. By constructing a system dynamics (SD) model for the VFM quantitative evaluation of SCC PPP projects from the perspective of the whole life cycle, this study can intuitively and transparently observe the impact of key factors (such as discount rate and profit margin) on the evaluation results and feasibility of adopting a PPP model in the project, offering policymakers a tool to mitigate the risks of “Pseudo-PPP” projects. After collecting cases in Anhui province from the China PPP Center, this study constructed a life cycle VFM quantitative evaluation system dynamics model suitable for SCC PPP projects that consist of the public sector comparison (PSC) value and PPP value. The results indicate that the system dynamics model can be effectively applied to the dynamic quantitative evaluation of SCC PPP projects and clarify the influence degree on and sensitivity of various factors to the VFM value. Specifically, when the discount rate increases, the decrease in the PPP value is greater than that in the PSC value, leading to an increase in the VFM value. Moreover, a reasonable profit margin is more sensitive to the VFM value and decreases as the reasonable profit margin increases. In addition, choosing different availability service fee calculation methods will result in varying the adjustment range to a reasonable profit margin that drives the adoption of VFM quantitative evaluation. These research findings have provided a viable dynamic research methodology for the quantitative VFM evaluation of SCC PPP projects. This methodology enables the dynamic visualization and easy determination of the acceptable ranges for relevant factors, offers rational policy recommendations for the quantitative evaluation of key factor values, and thereby effectively prevents PPP project violations, promoting fair and reasonable cooperation between governments and private enterprises. Full article

Although impulsive and hedonic purchasing behaviors may seem to contradict sustainability principles, there are unexplored opportunities through which social media platforms and influencers can redirect these impulses toward sustainable actions. Young consumers, increasingly concerned about the ecological impact of their choices, can be encouraged to adopt responsible and sustainable buying behaviors when these are promoted attractively, enjoyably, and emotionally satisfyingly through social media. This research investigates how social media communication influences hedonic and impulsive purchasing behavior in the Romanian clothing market. In the context where social media is one of the main sources of information and influence for consumers, the research analyzes several determining factors of the purchase decision. Price reductions and the use of credit cards are highlighted as elements that facilitate spontaneous and hedonic targeted purchases, while the attractiveness of clothing items and the need felt play an important role in terms of the desire to buy. In addition, sources of information (such as reviews) have a major impact on consumers’ perceptions and their purchase intentions. Additionally, the study investigates factors such as overall shopping experience and its influence on consumer loyalty. It is approached from two perspectives: attitudinal loyalty, reflected in the preference for brands promoted on social media, and behavioral loyalty, expressed through repeat purchases. The results show that social media acts as an accelerator for hedonic and impulsive buying behaviors, prompting consumers to react quickly to stimuli such as discount campaigns or personalized recommendations. The conclusions highlight the importance of adopting digital marketing strategies that capitalize on the consumers emotional need while also strengthening brand loyalty. These perspectives can guide companies in the clothing industry to adapt their promotion methods to the specifics of the Romanian market and the consumer behavior. Full article

Key core technology innovation has become an important strategic path for countries to maintain industrial security amid intensifying global technological competition. As an important innovation paradigm, R&D collaboration is generally regarded as an effective way to achieve such innovation. However, the key issue of which collaborative mechanism is most effective at promoting key core technology innovation remains insufficiently explored. Therefore, systematically comparing the effectiveness of different mechanisms of collaborative innovation is of great strategic significance for achieving key core technology innovation and overcoming Western technological blockades. In this study, the R&D level and market share of key core technology were incorporated into an analytical framework and applied to a differential game focused on the innovation behaviors of leading enterprises, supporting enterprises, and academic research institutions under Nash non-collaborative, cost-sharing, and collaborative mechanisms. A simulation analysis was conducted using the MATLAB 2020a software. The results show that the optimal strategies for the key core technology innovation of innovation entities are negatively correlated with the cost coefficient, discount rate, technology, and market recession coefficient. Meanwhile, they are positively correlated with the sensitivity coefficient of technology R&D and market promotion. Furthermore, the R&D levels and market shares of key core technology are highest under the collaborative mechanism. In this scenario, the revenues of the innovation entity and the overall system reach Pareto optimality. Within a threshold range, the cost-sharing mechanism significantly improves innovative efforts, the R&D level, and the market share of key core technology, leading to a Pareto improvement for both the participants’ and overall system’s revenues compared to the non-collaborative mechanism. This study not only contributes to theoretical results of differential games but also provides valuable suggestions for policymakers and innovation entities to foster key core technology innovation from the perspective of collaboration. Full article

The cattle sector plays a critical role in Peru’s agricultural economy, yet it faces challenges related to low productivity and environmental degradation. Sustainable alternatives like silvo-pastoral systems (SPSs) offer promising solutions to enhance both economic returns and ecological outcomes in cattle farming. This study examines the economic viability of an intensive SPS (SPSi) compared to traditional monoculture grass systems in San Martín, Peru. The SPSi under study is in the evaluation phase, integrates grasses, legumes, shrubs, and trees, and has the potential to enhance cattle farming profitability while simultaneously offering environmental benefits such as improved soil health and reduced greenhouse gas emissions. Through a discounted cash flow model over an eight-year period, key profitability indicators—Net Present Value (NPV), Internal Rate of Return (IRR), Benefit–Cost Ratio (BC), and payback period—were estimated for four dual-purpose cattle production scenarios: a traditional system and three SPSi scenarios (pessimistic, moderate, and optimistic). Monte Carlo simulations were conducted to assess risk, ensuring robust results. The results show that the NPV for the traditional system was a modest USD 61, while SPSi scenarios ranged from USD 9564 to USD 20,465. The IRR improved from 8.17% in the traditional system to between 26.63% and 30.33% in SPSi scenarios, with a shorter payback period of 4.5 to 5.8 years, compared to 7.98 years in the traditional system. Additionally, the SPSi demonstrated a 30% increase in milk production and a 50% to 250% rise in stocking rates per hectare. The study recommends, subject to pending validations through field trials, promoting SPSi adoption through improved access to credit, technical assistance, and policy frameworks that compensate farmers for ecosystem services. Policymakers should also implement monitoring mechanisms to mitigate unintended consequences, such as deforestation, ensuring that SPSi expansion aligns with sustainable land management practices. Overall, the SPSi presents a viable solution for achieving economic resilience and environmental sustainability in Peru’s cattle sector. Full article

This research examined the persuasive impact of social norms and financial incentive messaging for encouraging reusable bag use. In an online experiment with a nationally representative sample from the U.S. (n = 753), participants were randomly exposed to static or dynamic descriptive/injunctive norms, discounts/surcharges, combinations, or a control message. Intentions to bring reusable bags when grocery shopping, along with other key demographic and psychological variables, were assessed. ANCOVA results demonstrate the main effects of the messages. Planned contrasts revealed that injunctive norms elicited higher intentions than descriptive norms. Dynamic descriptive norms led to stronger intentions compared to static descriptive norms, with no difference shown between the two injunctive norm conditions. Notably, combining injunctive norms with either incentive boosted intentions beyond standalone messaging, supporting motivational complementarity. Norms overall outperformed incentives, but integrating social and economic appeals shows promise. The predicted superiority of experimental messages in promoting intentions, when compared to a generic pro-environmental appeal (control), was not supported. The findings advance an integrated behavior change approach highlighting normative information and incentives, shedding light on optimal messaging strategies amid pro-environmental interventions. Full article

As the online shopping user base continues to grow rapidly, livestream e-commerce has emerged as a pivotal commercial phenomenon. However, consumers’ impulse purchase intentions in this environment are influenced by numerous interrelated factors, and the underlying mechanisms remain complex. To address the limitations of traditional approaches in modeling nonlinear relationships and hierarchical structures, this study introduces an integrated DEMATEL-AISM approach tailored for the livestream e-commerce context. The $\lambda$-intercept method is applied to simplify the system structure and highlight key influencing factors. Based on prior literature, we designed and distributed structured questionnaires to 558 consumers and industry experts, followed by in-depth interviews with five domain experts. Through this process, an indicator system was developed encompassing 15 factors across three dimensions: product, consumer, and livestream room. Using DEMATEL-AISM, we conducted a causal analysis of these factors. The results reveal that: (1) discount intensity, livestream promotional frameworks, and time pressure are the three most critical factors influencing impulse purchase intentions; (2) product monetary value and design features act as fundamental drivers; and (3) consumer upward and downward anticipated regret, perceived product quality, perceived product scarcity, and perceived streamer’s product knowledge have direct impacts on impulse purchase. By identifying these key factors and revealing their interconnections, this study offers strategic, evidence-based recommendations for enhancing consumer engagement and profitability in livestream e-commerce. The proposed DEMATEL-AISM also provides a novel and effective methodological contribution for analyzing the complex influencing factors of impulse purchase intentions in the e-commerce environment. Full article

This study examines strategies to enhance transport inclusivity and passenger satisfaction for persons with disabilities in public bus systems in the Philippines. Drawing on data collected through an online questionnaire from 396 persons with disabilities who responded across various regions in the country, this study investigates eight key factors affecting satisfaction: vehicle design, diverse seating options, sensory considerations, assistance services, safety measures, subsidies/discounts, accessibility, and communication and information quality. Structural equation modeling (SEM) was used to analyze the hypothesized relationships between these variables, passenger satisfaction, and intention to reuse public transport. The SEM results revealed that accessibility (β = 0.359, p = 0.005), vehicle design (β = 0.248, p < 0.001), diverse seating options (β = 0.485, p < 0.001), safety measures (β = 0.3867, p = 0.001), and subsidies/discounts (β = 0.447, p < 0.001) significantly influenced passenger satisfaction. In turn, satisfaction had a strong positive effect on the future intention to use public transport (β = 0.760, p < 0.001). However, sensory considerations (β = 0.163, p = 0.225), assistance (β = 0.133, p = 0.519), and communication and information quality (β = 0.171, p = 0.345) were not statistically significant. The model demonstrated a good fit (chi-square/df = 4.03; SRMR = 0.078; NFI = 0.956), supporting the robustness of the proposed framework. These findings suggest that design-centered improvements and subsidies/discounts are critical to inclusive transport experiences, while overreliance on assistance may not guarantee satisfaction. This study recommends promoting autonomy through universal design, enhancing digital and physical accessibility, and increasing public awareness. These insights are intended to guide policymakers and transit authorities in creating a more inclusive, equitable, and user-driven transportation system. Full article

The intensification of agricultural practices, such as the extensive use of synthetic fertilizers, the expansion of irrigation systems, and land use conversion, has led to substantial biodiversity loss and the disruption of ecosystem functions. Traditional washing procedures for fresh produce involve substantial water usage and can generate wastewater, which requires proper management to prevent environmental contamination. By skipping the washing stage, these reduced water and energy inputs contribute to more sustainable agricultural practices. Although this approach may benefit sustainability and the environment, the market success of a product with a sustainable attribute ultimately depends on consumer acceptance and their willingness to pay (WTP) for it. This study investigates consumer preferences and WTP for a local potato variety called “Agria”, with a specific focus on the sustainability attribute concerning the sale of washed versus unwashed potatoes. We conducted an experimental study with consumers in northeastern Spain, where this potato variety is grown, and simulated market shares under varying price scenarios. The methodology involved a choice experiment that evaluated three characteristics: price, local origin, and presentation (washed versus unwashed). The methodology also incorporated attribute non-attendance (ANA) to capture all aspects of the decision-making process. The findings reveal that consumers preferred the locally grown variety over those from other origins and were willing to pay a premium. Although consumers preferred washed potatoes, they would purchase unwashed potatoes at a discount price of EUR 0.2/kg. The results provide marketing and pricing strategies for local producers and retailers and market share projections aligned with consumer preferences for local food. Empirically, the study contributes to the literature on consumer preferences and sustainable food systems by (i) integrating the “washed versus unwashed” attribute with local origin to inform more effective marketing strategies; and (ii) supporting local potato growers through the identification of viable lunch strategies for a differentiated, unwashed product that extends shelf life, reduces food waste, and promotes sustainability by lowering water and energy use in post-harvest processing. For methodologically, it applies ANA in the context of potato choice experiments—an approach rarely used in this domain—to enhance the understanding of consumer decision-making. Full article

The differential toll policy has emerged as an effective method for regulating expressway traffic flow and has positively impacted the efficiency of vehicular movement, as well as balanced the spatial and temporal distribution of the road network. However, the acceptance of differentiated charging policies and the range of rates associated with these policies warrant further investigation. This study employs both revealed preference (RP) and stated preference (SP) survey methods to assess users’ willingness to accept the current differentiated toll scheme and to analyze the proportion of users opting for alternative travel routes and their behavioral characteristics in simulated scenarios. Additionally, we construct a Structural Equation Model-Latent Class Logistics (SEM-LCL) to explore the mechanisms influencing differentiated toll road alternative travel choices while considering user heterogeneity. The findings indicate that different tolling strategies and discount rates attract users variably. The existing differentiated tolling scheme—based on road sections, time periods, and payment methods—significantly affects users’ choices of alternative routes, with the impact of tolling based on vehicle type being especially pronounced for large trucks. The user population is heterogeneous and can be categorized into three distinct groups: rate-sensitive, information-promoting, and conservative-rejecting. Furthermore, the willingness to consider alternative travel routes is significantly influenced by factors such as gender, age, driving experience, vehicle type, travel time, travel distance, payment method, and past differential toll experiences. The results of this study provide valuable insights for highway managers to establish optimal toll rates and implement dynamic flow regulation strategies while also guiding users in selecting appropriate driving routes. Full article

Retailing strategy can be considered as the most critical factor for the success of industries. Managing deteriorating products in retail demands a strategic approach aimed at mitigating losses while maximizing profitability. This entails a proactive stance towards identifying products nearing expiration, becoming obsolete or showing signs of deterioration. Offering discounts or promotions can stimulate consumer interest and clear out inventory. The promotion of products within the context of retail management involves a multifaceted approach aimed at increasing awareness, generating interest, and ultimately driving sales. Sustainability helps retailers to develop social as well as economic consistency. Every country and their respective governments are currently working towards sustainable development. New technologies in this direction have been introduced. The present paper introduces a retailing model considering green technology as it is becoming popular to lower environmental risks. The items considered in this study are perishable in nature. As product prices and the promotion of products highly influence demand, a demand pattern dependent on price and promotion is therefore considered. This paper presents a sustainable retail-based inventory model that considers preservation technology to lower the rate of deterioration and increase product shelf life. As carbon emissions is currently the biggest threat to the environment, enforcing a penalty may lower its emissions. Carbon emissions costs due to storage, transportation, and preservation are considered herein. This model studies the effect of various cost parameters on the model. A numerical analysis is performed to validate the result. The results of this study show that the implementation of preservation technology not only increases cycle time but also significantly reduces total cost, hence increasing profit. Sensitivity analysis is performed to show the behaviors of different cost parameters on total cost and decision variables. Mathematica 11 and Maple 18 software are used for graphical representation. Full article

The objective of this study was to address the limitations of biodegradable plastics—low economic benefits and marketing difficulties. To this end, this study analyzed the production processes of two biodegradable plastics: polylactic acid (PLA) and polybutylene adipate terephthalate (PBAT). Based on this analysis, economic, technical, and environmental improvement indicators were constructed, and an optimization model with the three objectives of profit, carbon emission cost, and process risk was established. In this study, we embedded the improved NSGA-III algorithm to obtain the Pareto optimal solution set. We also proposed the entropy-weighted efficiency index (EWEI) for the analysis of transport advantages based on the distribution of biodegradable plastics production, road density, and regional prices. With a production line capacity of 10,000 tons and an 8% discount rate, the 10-year return of PBAT products was 7,039,931.23 yuan higher than that of PLA products. The profit of PBAT products was 488.92 yuan higher than that of PLA products per ton of production. However, PBAT products exhibited higher carbon-emission cost and process risk than PLA products, especially process risk, by 0.11%. The East China region has obvious geographical advantages, but the Southwest region is constrained by limitations in production capacity and the presence of mountainous terrain. Therefore, it is imperative to optimize China’s overall industrial layout of biodegradable plastics, strengthen the profit acquisition of biodegradable plastics, support the sustainable promotion of the biodegradable plastics market, and effectively minimize the environmental pollution caused by traditional plastics. Full article

Sustainable transport is an important trend in smart cities to achieve sustainability development goals. It refers to the use of transport modes with low emissions, energy consumption and negative impacts on the environment. Ridesharing is one important sustainable transport mode to attain the goal of net zero greenhouse gas emissions. The discount-guaranteed ridesharing problem (DGRP) aims to incentivize drivers and riders and promote ridesharing through the guarantee of a discount. However, the computational complexity of the DGRP poses a challenge in the development of effective solvers. In this study, we will study the effectiveness of creating new self-adaptive differential evolution (DE) algorithms based on an old saying to solve the DGRP. Many old sayings still have far-reaching implications today. Some of them influence the organization of management teams for companies and decisions to improve performance and efficiency. Whether an old saying that works effectively for human beings to solve problems can also work for developers to create effective optimization problem solvers in the realm of artificial intelligence is an interesting research question. In our previous study, one self-adaptive algorithm was proposed to solve the DGRP. This study demonstrates how to create a series of self-adaptive algorithms based on the old saying “Two heads are better than one” and validates the effectiveness of this approach based on experiments and comparison with the algorithms proposed previously. The new finding of this study is that the old saying not only works effectively for human beings to solve problems but also works effectively in the creation of new scalable and robust self-adaptive algorithms to solve the DGRP. In other words, the old saying provides a simple and systematic approach to the development of effective optimization problem solvers in artificial intelligence. Full article