Search Results (17)

Background: Olfactory dysfunction (OD)—including anosmia and hyposmia—is a common and often persistent outcome of viral infections. This systematic review consolidates findings from structural and functional MRI studies to explore how COVID-19 SARS-CoV-2-induced smell loss alters the brain. Considerable heterogeneity was observed across studies, influenced by differences in methodology, population characteristics, imaging timelines, and OD classification. Methods: Following PRISMA guidelines, we conducted a systematic search of PubMed/MEDLINE, Scopus, and Web of Science to identify MRI-based studies examining COVID-19’s SARS-CoV-2 OD. Twenty-four studies were included and categorized based on imaging focus: (1) olfactory bulb (OB), (2) olfactory sulcus (OS), (3) grey and white matter changes, (4) task-based brain activation, and (5) resting-state functional connectivity. Demographic and imaging data were extracted and analyzed accordingly. Results: Structural imaging revealed consistent reductions in olfactory bulb volume (OBV) and olfactory sulcus depth (OSD), especially among individuals with OD persisting beyond three months, suggestive of inflammation and neurodegeneration in olfactory-associated regions like the orbitofrontal cortex and thalamus. Functional MRI studies showed increased connectivity in early-stage OD within regions such as the piriform and orbitofrontal cortices, possibly reflecting compensatory activity. In contrast, prolonged OD was associated with reduced activation and diminished connectivity, indicating a decline in olfactory processing capacity. Disruptions in the default mode network (DMN) and limbic areas further point to secondary cognitive and emotional effects. Diffusion tensor imaging (DTI) findings—such as decreased fractional anisotropy (FA) and increased mean diffusivity (MD)—highlight white matter microstructural compromise in individuals with long-term OD. Conclusions: COVID-19’s SARS-CoV-2 olfactory dysfunction is associated with a range of cerebral alterations that evolve with the duration and severity of smell loss. Persistent dysfunction correlates with greater neural damage, underscoring the need for longitudinal neuroimaging studies to better understand recovery dynamics and guide therapeutic strategies. Full article

Homogenized micro-crack crushing is an optimal rehabilitation technology for concrete pavement; however, when there are weak road base issues, some measures need to be taken to treat the diseases. Grouting is a common technique for addressing weak road base issues. This study developed a new visual indoor grouting test system to analyze the diffusion and consolidation of slag-based geopolymer slurry. The reactants of the geopolymer and the consolidation state of the slurry and aggregate were observed. Moreover, the reinforcement effect of the slurry on a weak road base was studied through the on-site grouting and excavation of the test pit. The results show that, during indoor grouting tests, as the size of the aggregate decreases, the slurry diffusion depth gradually decreases: only 9.5–4.75 mm aggregate formed a complete cylindrical specimen. In the tests of unformed cylindrical specimens, the 9.5–4.75 mm aggregate will develop 20–50 mm splitting surfaces, while the 4.75–2.36 mm aggregate will develop slurry bulbs and veins of different sizes, but the development is not obvious in the 2.36–1.18 mm aggregate. Fine aggregate grouting will exhibit the pressure filtration effect—especially for the 2.36–1.18 mm aggregate, the pressure filtration effect is the most obvious. An SEM microstructural analysis demonstrated that the geopolymer with a water–slag ratio of 0.4 has a faster hydration and dissolution, which results in a decrease in the density of local reactants. However, the polymerization of geopolymers is more complete. The pores of the coarse aggregate are larger and the slurry filling is denser, while the pores of the fine aggregate are smaller and the consolidation is loose locally. The consolidation of aggregates has cracks at local locations, but the width of the cracks is relatively small. On-site grouting applications revealed that the geopolymer slurry filled the bottom voids of pavement slabs and deep gaps in the road base layers, and the average deflection of the driveway decreased from 104.8 (0.001 mm) to 48 (0.001 mm) after grouting. Weak road base conditions were successfully treated, leading to a significant improvement in bearing capacity. Full article

With the increasing construction of engineering structures on soft soils, accurately assessing their consolidation behavior has become crucial. To address this, Terzaghi’s one-dimensional consolidation model was revisited. The elastic behavior of soil skeleton was modified by incorporating viscous effects using the fractional derivative Merchant model (FDMM), while the linear Darcy’s law governing flux–pressure relations was extended by introducing time memory formalism through the fractional derivative Darcy model (FDDM). The governing equation is derived by incorporating the resulting constitutive behavior of both the soil skeleton and water flow into the Terzaghi’s formulation of the poroelasticity problem. The proposed rheological consolidation model is solved by a forward time-centered space scheme (FTCS). After verifying the numerical procedure with published data, the influence of parameters on both the average degree of settlement and the pressure was comprehensively studied. Full article

Background/Objectives: Primary cutaneous B-cell lymphomas (PCBCL) are a rare and heterogeneous group of non-Hodgkin lymphomas that are confined to the skin at diagnosis and exhibit a tendency for cutaneous recurrence. The 5th edition of the World Health Organization and the 2022 International Consensus Classification recognize three main subtypes: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma/lymphoproliferative disorder (PCMZL/LPD), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL,LT). These subtypes differ in clinical behavior, histopathologic features, immunophenotype, and molecular alterations. Diagnosis and management remain challenging for clinicians. This review aims to provide a comprehensive overview of the defining features and current treatment strategies for PCBCL. Methods: This narrative review synthesizes current literature on the clinical, morphologic, immunohistochemical, and molecular characteristics of PCBCL. It also evaluates the diagnostic utility of immunohistochemistry, gene expression profiling, and molecular assays, particularly in distinguishing primary cutaneous disease from secondary cutaneous involvement by systemic lymphomas. Results: PCFCL arises from germinal center B-cells and must be differentiated from nodal follicular lymphoma. PCMZL/LPD is derived from post-germinal center B-cells and is often linked to chronic antigenic stimulation. Both PCFCL and PCMZL/LPD are indolent and associated with favorable outcomes. By contrast, PCDLBCL,LT is an aggressive lymphoma characterized by genetic alterations activating the NF-κB pathway, commonly including mutations to MYD88 and CD79B. Treatment strategies vary by subtype, ranging from localized therapies for indolent lymphomas to systemic chemoimmunotherapy for aggressive PCBCL. Emerging therapies, such as Bruton tyrosine kinase inhibitors and immunoregulatory agents, are being investigated for relapsed/refractory disease. Conclusions: PCBCL encompass distinct clinicopathologic entities with subtype-specific diagnostic and therapeutic considerations. While current management is guided by clinical behavior, significant knowledge gaps remain regarding the molecular mechanisms underlying skin tropism, immune evasion, and disease progression. Future research could focus on improving molecular characterization and developing personalized and immune-based therapies to enhance outcomes. This review consolidates current knowledge and highlights innovations aimed at advancing the diagnosis and treatment of PCBCL in clinical practice. Full article

Titanium (Ti) is widely used in structural, maritime, aerospace, and biomedical applications because of its outstanding strength-to-weight ratio, superior corrosion resistance, and excellent biocompatibility. However, the lower surface hardness and inferior wear resistance of the Ti and Ti alloys limit their industrial applications. Coating Ti surfaces can initiate new possibilities to give unique characteristics with significant improvement in the Ti component’s functionality. The current research designed and synthesized titanium nitride (TiN), titanium carbide (TiC), titanium carbonitride (TiCN), tantalum nitride (TaN), and niobium nitride (NbN) ceramic coating layers (400 µm) over a Ti substrate using a spark plasma sintering process (SPS). The coatings on the Ti substrate were compact and consolidated at an SPS temperature of 1500 °C, pressure of 50 MPa, and 5 min of holding time in a controlled argon atmosphere. Microstructure investigation revealed a defect-less coating-substrate interface formation with a transition/diffusion zone ranging from 10 µm to 20 µm. Among all of the ceramic coatings, titanium carbide showed the highest improvement in surface hardness, equal to 1817 ± 25 HV, and the lowest coefficient of friction, equal to 0.28 for NbN. Full article

Diffusion bonding is a process that has proven effective for the joining of metal to ceramic, but the differences in coefficient of thermal expansion still pose challenges during and after the bonding process. This work details the exploration of traditional diffusion-bonding processes using two traditional approaches, which include bonding of a 99.9+% pure Ni foil to SiC, Si₃N₄, and YSZ disks using (1) a hot isostatic press (HIP), with and without added weight to promote interfacial contact, and (2) field-assisted sintering (FAST). Samples were consolidated by heating to 1200 °C and held for 6 h under vacuum before cooling to room temperature during the HIP method. For the FAST technique, bonding experiments were performed at both 800 °C and 1200 °C in a vacuum environment under 10 MPa uniaxial pressure. After the Ni was bonded to the ceramics, diffusion heat treatments were carried out in the HIP. For electroless-plated samples, the heat-treatment temperature was chosen as 825 °C to avoid melting. For electroplated samples, heat treatment occurred at 925 °C or higher. Electroplated YSZ samples were heat-treated at 1150 °C as the Ni-Si eutectic is not a concern in this system. The time at temperature varied from 6 h to 48 h depending on the material combination tested. Post-heat-treatment diffusion characteristics were analyzed using scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDS). A main cause of poor bonding performance in the HIP samples was reduced interfacial contact, while cohesive failures in the FAST samples are likely due to the formation of brittle intermetallic Ni-Si phases. Preliminary results indicate success in bonding Ni to SiC, Si₃N₄, and YSZ using a diffusion-enhanced approach on electroplated specimens. Full article

To study the flow and strength characteristics of loess-based backfill materials, orthogonal tests were used to design a cemented backfill material combining loess, high-water content materials, cement, and fly ash. By using the range, analysis of variance, and multi-variate regression analysis, influences of four key factors on the initial setting time, diffusivity, compressive strength, and shear strength of the backfill material were investigated. These four factors included the mass concentration of loess water (A), the content of high-water content materials (B), cement content (C), and content of fly ash (D). The results showed that the initial setting time, diffusivity, compressive strength, and shear strength of the backfill material were 13~33 min, 400~580 mm, 0.917–3.605 MPa, and 0.360–0.722 MPa, respectively, all distributed in wide ranges. For the initial setting time, the four factors were listed in descending order as A > D > B > C according to their influences; for diffusivity, the four factors were listed as A > B > C > D; for the compressive strength, the four factors were ranked as A > C > D > B; for the shear strength, the four factors were ranked such that A > C > D > B. With regard to the comprehensive index, the four factors were such that A > B > D > C. That is, the factors were listed in descending order as the mass concentration of loess water, cement content, the content of fly ash, and content of high-water content materials according to their significance in influencing characteristics of the loess-based backfill material. Comprehensive analysis indicated that the fluidity of the material was mainly influenced by the mass concentration of loess water, and the two were negatively correlated. The hydro-consolidation effect of materials with high-water contents accelerated material solidification. The strength of the backfill material was mainly influenced by the cement content while only slightly affected by contents of other materials. In this way, a prediction model for characteristic parameters, namely, fluidity and strength, of the loess-based backfill material under the action of various factors was established. Full article

A large-scale immersion experiment was carried out to assess the collapsibility characteristics of loess in Bu Li village located in the Weibei Loess Tableland, and the seepage characteristics and collapsibility evolution of loess were determined. The effects of void ratio, natural moisture content, material composition, and microstructure evolution on the loess collapsibility were characterized by X-ray diffraction, scanning electron microscopy, and water-soluble salt analysis to elucidate the collapsibility mechanisms. The water diffusion morphologies considering various foundation lithologies, initial water contents, and stratum combinations were studied with the numerical simulation method, and an inverted-box-shape barrier measure preventing loess from the water immersion was proposed. The results showed that the maximum consolidation settlement was approximately 380.5 mm for the test site, and the expansion of clay minerals and the dissolution of soluble salts during wetting were the critical reasons for loess collapse. The void ratio and natural moisture content showed a positive and negative correlation with the collapsibility coefficient, respectively, and the concept of collapsibility potential was introduced. The water diffusion morphologies in distinct stratum combinations significantly depended on the permeability capacity of the lower soil layer, and the optimal depths of the vertical barrier were recommended to be set at the maximum inflection point in the diffusion morphology or the main action layer. Full article

Many composite manufacturing processes employ the consolidation of pre-impregnated preforms. However, in order to obtain adequate performance of the formed part, intimate contact and molecular diffusion across the different composites’ preform layers must be ensured. The latter takes place as soon as the intimate contact occurs and the temperature remains high enough during the molecular reptation characteristic time. The former, in turn, depends on the applied compression force, the temperature and the composite rheology, which, during the processing, induce the flow of asperities, promoting the intimate contact. Thus, the initial roughness and its evolution during the process, become critical factors in the composite consolidation. Processing optimization and control are needed for an adequate model, enabling it to infer the consolidation degree from the material and process features. The parameters associated with the process are easily identifiable and measurable (e.g., temperature, compression force, process time, ⋯). The ones concerning the materials are also accessible; however, describing the surface roughness remains an issue. Usual statistical descriptors are too poor and, moreover, they are too far from the involved physics. The present paper focuses on the use of advanced descriptors out-performing usual statistical descriptors, in particular those based on the use of homology persistence (at the heart of the so-called topological data analysis—TDA), and their connection with fractional Brownian surfaces. The latter constitutes a performance surface generator able to represent the surface evolution all along the consolidation process, as the present paper emphasizes. Full article

Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS). DAD is independently correlated with higher mortality compared with the absence of DAD. Traction bronchiectasis in areas of ground-glass opacity or consolidation is associated with the late fibroproliferative or fibrotic phase of DAD. This study examined whether the 60-day mortality related to DAD could be predicted using high-resolution computed tomography (HRCT) findings and HRCT scores. A total of 34 patients with DAD who received HRCT within 7 days of ARDS diagnosis were enrolled; they were divided into a 60-day survival group and a nonsurvival group, with 17 patients in each group. Univariate and multivariate binary regression analyses and the receiver operating characteristic curve revealed that only the total percentage of the area with traction bronchiectasis or bronchiolectasis was an independent predictor of 60-day mortality (odds ratio, 1.067; 95% confidence interval (CI), 1.011–1.126) and had favorable predictive performance (area under the curve (AUC): 0.784; 95% CI, 0.621–0.946; cutoff, 21.7). Physiological variables, including age, days from ARDS to HRCT, the sequential organ failure assessment (SOFA) score, the PaO₂/fraction of inspired oxygen (FiO₂) ratio, dynamic driving pressure, and dynamic mechanical power, were not discriminative between 60-day survival and nonsurvival. In conclusion, the extent of fibroproliferation on HRCT in early ARDS, presented as the total percentage of area with bronchiectasis or bronchiolectasis, is an independent positive predictor with a favorable predictive ability for the 60-day mortality of DAD. Full article

Cement-sodium silicate grout (CSG) is now widely adopted in water plugging engineering to prevent water inrush disasters, and the gelation and consolidation characteristics of CSG in water environment significantly affect the grouting effect. To obtain an in-depth understanding of the performance of CSG in water, the CSGs with different water-cement ratios and volume ratios were tested, and the gelation properties, the deposition characteristics and the diffusion process of CSG within water were examined. The compressive strength and microstructure of CSG consolidation formed in air and water were also analyzed comparatively. The test results indicate that the CSG consolidation exhibits obvious stratification and segregation phenomena in water, which can be divided into three layers with different substance compositions. The compressive strength of CSG consolidation formed in water is much lower than that of the grout consolidation formed in air, indicating that the water environment has a significant weakening effect on the consolidation properties of CSG. The hydration products and microstructure of CSG consolidation in water change clearly due to the dilution effect of water. Full article

Spain has more than 2.5 M ha of olive groves, with 60% of this area (i.e., 1.5 M ha) concentrated in the region of Andalusia (Southern Spain). Assuming the socio-ecological characteristics of these crops, of which their contribution to ecosystemic services (ES) is fundamental for society, it is highly relevant to direct their management towards practices that guarantee their durability. Organic management of olive groves constitutes a multifunctional model that contributes to ensuring its sustainability and represents 2.4–3.5% of the olive grove area in Spain. Taking the Protected Designation of Origin (PDO) Estepa (Southwestern Spain) as a study model, where organic olive groves are novel, a study of the impacts of erosion on the economic, social, and environmental factors associated with this management was carried out in addition to estimating its impacts. The results showed how organic management promotes edaphic fertility, keeping the levels of diffuse pollution under the legislative limits. Although the increase in erosion has negative effects on the sustainability/durability of agricultural holdings, organic management consolidates a sustainable model that satisfies farmers’ demands. Therefore, organic farming is a model that focuses on the correct use of natural resources associated with the geographical region of study, and contributes to increasing the sustainability of olive groves. Full article

The laser sintering of polymers is an additive manufacturing technology that is becoming increasingly established in the industrial environment. This study investigated the thickness-dependent permeation properties of laser-sintered (LS) polymers as required to design and produce components with a special barrier performance to gaseous substances. Helium and oxygen permeation experiments were carried out on quenched and standard LS polyamide 12 (PA12) sheets generated with two, four, six, and eight layers at a constant powder layer thickness of 100 µm. The structural properties of the sheets were examined by differential scanning calorimetry, light microscopy, and X-ray micro-computed tomography. A reduction in thickness resulted in higher diffusion coefficients for both types of LS sheets. An explanation could be the large volume fraction of poorly sintered powder particles adhering to the surfaces and incomplete melting and low consolidation of the polymer at small thicknesses. The thickness-dependency of the solubility coefficients was the opposite, especially for the standard LS sheets, which might be related to the larger pore volume in thicker sheets. As both effects compensated for each other, nearly constant permeation coefficients for all thicknesses were observed. The results provide further insights into different material characteristics of thin LS PA12 structures and offer new information on factors relevant to their solution and diffusion behavior. Full article

The magnetic properties of the recycled hydrogenation disproportionation desorption recombination (HDDR) Nd-Fe-B powder, doped with a low weight fraction of DyF₃ nanoparticles, were investigated. Spark plasma sintering (SPS) was used to consolidate the recycled Nd-Fe-B powder blends containing 1, 2, and 5 wt.% of DyF₃ grounded powder. Different post-SPS sintering thermal treatment conditions (600, 750, and 900 °C), for a varying amount of time, were studied in view of optimizing the magnetic properties and developing characteristic core-shell microstructure in the HDDR powder. As received, recycled HDDR powder has coercivity (H_Ci) of 830 kA/m, and as optimally as SPS magnets reach 1160 kA/m, after the thermal treatment. With only 1–2 wt.% blended DyF₃, the H_Ci peaked to 1407 kA/m with the thermal treatment at 750 °C for 1 h. The obtained H_Ci values of the blend magnet is ~69.5% higher than the starting recycled HDDR powder and 17.5% higher than the SPS processed magnet annealed at 750 °C for 1 h. Prolonging the thermal treatment time to 6 h and temperature conditions above 900 °C was detrimental to the magnetic properties. About ~2 wt.% DyF₃ dopant was suitable to develop a uniform core-shell microstructure in the HDDR Nd-Fe-B powder. The Nd-rich phase in the HDDR powder has a slightly different and fluorine rich composition i.e., Nd-O-F₂ than in the one reported in sintered magnets (Nd-O-F). The composition of reaction zone-phases after the thermal treatment and Dy diffusion was DyF₄, which is more abundant in 5 wt.% doped samples. Further doping above 2 wt.% DyF₃ is ineffective in augmenting the coercivity of the recycled HDDR powder, due to the decomposition of the shell structure and formation of non-ferromagnetic rare earth-based complex intermetallic compounds. The DyF₃ doping is a very effective single step route in a controlled coercivity improvement of the recycled HDDR Nd-Fe-B powder from the end of life magnetic products. Full article

The Taiwanese, who have accumulated rich experience from the strategy, have greatly promoted the development of the rural economy in mainland China through the establishment of rural Taiwanese enterprises. In the process of the strategy of rural revitalization, it is important to draw on the experience from Taiwan, and to acknowledge the leading role of Taiwanese entrepreneurs. In this study, we considered 941 rural Taiwanese enterprises that were registered in townships and villages in mainland China. Based on the cultural diffusion model, spatial analysis of GIS, and statistical methods, this study analyzed the spatial pattern and evolution of rural Taiwanese enterprises, and predicted the spatial diffusion pattern as well. The study found the following: (1) The reform and opening-up policy leads to the core position of Dongguan and Kunshan, and continues to consolidate the dual-core pattern with a noticeable combined effect. (2) Rural Taiwanese enterprises are mainly engaged in the secondary industry, with characteristics of small-scale and strong independence. They tend to be located in secondary cities in developed regions, in order to reduce costs and obtain maximum profits. (3) They display a V-shaped pattern covering the Eastern coastal line and Hunan-Sichuan line, with Guangdong as the node. (4) It is predicted that, in the next decade, the growth of the enterprises will slow down and their spatial diffusion pattern will be more conspicuous. While the spatial diffusion of Taiwanese enterprises slows down, more domestic investment may lead to industry vitalization in rural China. Full article