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Search Results (414)

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Keywords = design studios

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37 pages, 10560 KiB  
Article
Optimizing Building Performance with Dynamic Photovoltaic Shading Systems: A Comparative Analysis of Six Adaptive Designs
by Roshanak Roshan Kharrat, Giuseppe Perfetto, Roberta Ingaramo and Guglielmina Mutani
Smart Cities 2025, 8(4), 127; https://doi.org/10.3390/smartcities8040127 - 3 Aug 2025
Abstract
Dynamic and Adaptive solar systems demonstrate a greater potential to enhance the satisfaction of occupants, in terms of indoor environment quality and the energy efficiency of the buildings, than conventional shading solutions. This study has evaluated Dynamic and Adaptive Photovoltaic Shading Systems (DAPVSSs) [...] Read more.
Dynamic and Adaptive solar systems demonstrate a greater potential to enhance the satisfaction of occupants, in terms of indoor environment quality and the energy efficiency of the buildings, than conventional shading solutions. This study has evaluated Dynamic and Adaptive Photovoltaic Shading Systems (DAPVSSs) through a comprehensive analysis of six shading designs in which their energy production and the comfort of occupants were considered. Energy generation, thermal comfort, daylight, and glare control have been assessed in this study, considering multiple orientations throughout the seasons, and a variety of tools, such as Rhino 6.0, Grasshopper, ClimateStudio 2.1, and Ladybug, have been exploited for these purposes. The results showed that the prototypes that were geometrically more complex, designs 5 and 6 in particular, had approximately 485 kWh higher energy production and energy savings for cooling and 48% better glare control than the other simplified configurations while maintaining the minimum daylight as the threshold (min DF: 2%) due to adaptive and control methodologies. Design 6 demonstrated optimal balanced performance for all the aforementioned criteria, achieving 587 kWh/year energy production while maintaining the daylight factor within the 2.1–2.9% optimal range and ensuring visual comfort compliance during 94% of occupied hours. This research has established a framework that can be used to make well-informed design decisions that could balance energy production, occupants’ wellbeing, and architectural integration, while advancing sustainable building envelope technologies. Full article
(This article belongs to the Topic Sustainable Building Development and Promotion)
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22 pages, 4331 KiB  
Article
Simulation-Based Design of a Low-Cost Broadband Wide-Beamwidth Crossed-Dipole Antenna for Multi-Global Navigational Satellite System Positioning
by Songyuan Xu, Jiwon Heo, Won Seok Choi, Seong-Gon Choi and Bierng-Chearl Ahn
Sensors 2025, 25(15), 4665; https://doi.org/10.3390/s25154665 - 28 Jul 2025
Viewed by 195
Abstract
This paper presents the design of a wideband circularly polarized crossed-dipole antenna for multi-GNSS applications, covering the frequency range of 1.16–1.61 GHz. The proposed antenna employs orthogonally placed dipole elements fed by a three-branch quadrature hybrid coupler for broadband and wide gain/axial ratio [...] Read more.
This paper presents the design of a wideband circularly polarized crossed-dipole antenna for multi-GNSS applications, covering the frequency range of 1.16–1.61 GHz. The proposed antenna employs orthogonally placed dipole elements fed by a three-branch quadrature hybrid coupler for broadband and wide gain/axial ratio beamwidth. The design is carried out using CST Studio Suite for a single dipole antenna followed by a crossed-dipole antenna, a feed network, and the entire antenna structure. The designed multi-GNSS antenna shows, at 1.16–1.61 GHz, a reflection coefficient of less than −17 dB, a zenith gain of 3.9–5.8 dBic, a horizontal gain of −3.3 to −0.2 dBic, a zenith axial ratio of 0.6–1.0 dB, and horizontal axial ratio of 0.4–5.9 dB. The proposed antenna has a dimension of 0.48 × 0.48 × 0.25 λ at the center frequency of 1.39 GHz. The proposed antenna can also operate as an LHCP antenna for L-band satellite phone communication at 1.525–1.661 GHz. Full article
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24 pages, 56885 KiB  
Article
Bio-Crafting Architecture: Experiences of Growing Mycelium in Minimal Surface Molds
by Anca-Simona Horvath, Alina Elena Voinea and Radu Adrian Arieșan
Sustainability 2025, 17(15), 6835; https://doi.org/10.3390/su17156835 - 28 Jul 2025
Viewed by 371
Abstract
Mycelium is a living material that has gained popularity over the last decade in both architecture and design. Apart from understanding the physical behaviour of novel materials, it is also important to grasp how designers and the general audience perceive them. On the [...] Read more.
Mycelium is a living material that has gained popularity over the last decade in both architecture and design. Apart from understanding the physical behaviour of novel materials, it is also important to grasp how designers and the general audience perceive them. On the one hand, this study investigated mycelium growth in 3D-printed minimal surface shapes using a wood-based filament, and on the other hand, it examined how both designers and the general public experience interacting with mycelium. Using a material-driven design research method, a workshop with architecture students was conducted where various triply periodic minimal surfaces were designed and 3D printed. These shapes were used as molds and impregnated with mycelium, and the growth of mycelium was analyzed visually and photographically. Data on the experiences of the 30 workshop participants of working with mycelium was collected through a survey and analyzed qualitatively. After exhibiting results of the workshop in a public-facing exhibition, semi-structured interviews with members of the general public about their perceptions of mycelium were conducted. Three-dimensionally printed minimal surfaces with wood-based filaments can function as structural cores for mycelium-based composites, and the density of the minimal surface appears to influence mycelium growth, which binds to wood-based filaments. Students exhibited stronger feelings for living materials compared to non-living ones, displaying both biophilia and, to a lesser extent, biophobia. Introducing hands-on workshops with living and experimental materials in design studio settings can help future generations of designers develop sensibilities for, and a critical approach towards, the impact of their design decisions on the environment and sustainability. The study also contributes empirical data on how members of the general public perceive mycelium as a material for design. Full article
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25 pages, 3903 KiB  
Article
An Integrated Multi-Criteria Decision Method for Remanufacturing Design Considering Carbon Emission and Human Ergonomics
by Changping Hu, Xinfu Lv, Ruotong Wang, Chao Ke, Yingying Zuo, Jie Lu and Ruiying Kuang
Processes 2025, 13(8), 2354; https://doi.org/10.3390/pr13082354 - 24 Jul 2025
Viewed by 317
Abstract
Remanufacturing design is a green design model that considers remanufacturability during the design process to improve the reuse of components. However, traditional remanufacturing design scheme decision making focuses on the remanufacturability indicator and does not fully consider the carbon emissions of the remanufacturing [...] Read more.
Remanufacturing design is a green design model that considers remanufacturability during the design process to improve the reuse of components. However, traditional remanufacturing design scheme decision making focuses on the remanufacturability indicator and does not fully consider the carbon emissions of the remanufacturing process, which will take away the energy-saving and emission reduction benefits of remanufacturing. In addition, remanufacturing design schemes rarely consider the human ergonomics of the product, which leads to uncomfortable handling of the product by the customer. To reduce the remanufacturing carbon emission and improve customer comfort, it is necessary to select a reasonable design scheme to satisfy the carbon emission reduction and ergonomics demand; therefore, this paper proposes an integrated multi-criteria decision-making method for remanufacturing design that considers the carbon emission and human ergonomics. Firstly, an evaluation system of remanufacturing design schemes is constructed to consider the remanufacturability, cost, carbon emission, and human ergonomics of the product, and the evaluation indicators are quantified by the normalization method and the Kansei engineering (KE) method; meanwhile, the hierarchical analysis method (AHP) and entropy weight method (EW) are used for the calculation of the subjective and objective weights. Then, a multi-attribute decision-making method based on the combination of an assignment approximation of ideal solution ranking (TOPSIS) and gray correlation analysis (GRA) is proposed to complete the design scheme selection. Finally, the feasibility of the scheme is verified by taking a household coffee machine as an example. This method has been implemented as an application using Visual Studio 2022 and Microsoft SQL Server 2022. The research results indicate that this decision-making method can quickly and accurately generate reasonable remanufacturing design schemes. Full article
(This article belongs to the Section Manufacturing Processes and Systems)
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16 pages, 2799 KiB  
Article
Electromagnetic Wave-Absorption Properties of FDM-Printed Acrylonitrile–Styrene–Acrylate/Multi-Walled Carbon Nanotube Composite Structures
by Aobo Zhou and Yan Wang
Polymers 2025, 17(15), 2010; https://doi.org/10.3390/polym17152010 - 23 Jul 2025
Viewed by 256
Abstract
The growing need for lightweight, customizable electromagnetic wave absorbers with weather resistance in aerospace and electromagnetic compatibility applications motivates this study, which addresses the limitations of conventional materials in simultaneously achieving structural efficiency, broadband absorption, and environmental durability. We propose a fused deposition [...] Read more.
The growing need for lightweight, customizable electromagnetic wave absorbers with weather resistance in aerospace and electromagnetic compatibility applications motivates this study, which addresses the limitations of conventional materials in simultaneously achieving structural efficiency, broadband absorption, and environmental durability. We propose a fused deposition modeling (FDM)-based approach for fabricating lightweight wave-absorbing structures using acrylonitrile-styrene-acrylate (ASA)/multi-walled carbon nanotube (MWCNT) composites. Results demonstrate that CST Studio Suite simulations reveal a minimum reflection loss of −18.16 dB and an effective absorption bandwidth (RL < −10 dB) of 3.75 GHz for the 2 mm-thick composite plate when the MWCNT content is 2%. Through FDM fabrication and structural optimization, significant performance enhancements are achieved: The gradient honeycomb design with larger dimensions achieved an effective absorption bandwidth of 6.56 GHz and a minimum reflection loss of −32.60 dB. Meanwhile, the stacked stake structure exhibited a broader effective absorption bandwidth of 10.58 GHz, with its lowest reflection loss reaching −22.82 dB. This research provides innovative approaches for developing and manufacturing tailored lightweight electromagnetic wave-absorbing structures, which could be valuable for aerospace stealth technology and electromagnetic compatibility solutions. Full article
(This article belongs to the Section Polymer Processing and Engineering)
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27 pages, 2101 KiB  
Article
Optimizing Essential Oil Mixtures: Synergistic Effects on Cattle Rumen Fermentation and Methane Emission
by Memoona Nasir, María Rodríguez-Prado, Marica Simoni, Susana M. Martín-Orúe, José Francisco Pérez and Sergio Calsamiglia
Animals 2025, 15(14), 2105; https://doi.org/10.3390/ani15142105 - 16 Jul 2025
Viewed by 444
Abstract
Ruminant livestock contribute significantly to methane emissions, necessitating sustainable mitigation strategies. Essential oils (EOs) show promise for modulating ruminal fermentation, but their synergistic effects remain underexplored. Two 24 h in vitro experiments evaluated the synergistic effects of EO blends on rumen microbial fermentation. [...] Read more.
Ruminant livestock contribute significantly to methane emissions, necessitating sustainable mitigation strategies. Essential oils (EOs) show promise for modulating ruminal fermentation, but their synergistic effects remain underexplored. Two 24 h in vitro experiments evaluated the synergistic effects of EO blends on rumen microbial fermentation. Exp. 1 screened five oils using two triad combinations. Triad 1 tested 10 combinations of thyme (THY), peppermint (PPM), and cinnamon leaf (CIN) oils. Triad 2 tested 10 combinations of anise (ANI), clove leaf (CLO), and peppermint (PPM) oils. Each blend was tested at 400 mg/L, using batch culture methods measuring: pH, ammonia-N (NH3-N), and volatile fatty acids (VFAs). The two most effective blends, designated as T1 and T2, were selected for Exp. 2 to assess total gas and methane (CH4) production using pressure transducer methods. All treatments were incubated in a rumen fluid–buffer mix with a 50:50 forage-to-concentrate substrate (pH 6.6). In Exp. 1, data were analyzed according to the Simplex Centroid Design using R-Studio. In Exp. 2, an analysis was conducted using the MIXED procedure in SAS. Mean comparisons were assessed through Tukey’s test. The results from Exp. 1 identified CIN+PPM (80:20) and ANI+CLO (80:20) as optimal combinations, both increasing total VFAs while reducing acetate/propionate ratios and NH3-N concentrations. In Exp. 2, both combinations significantly reduced total gas and CH4 productions compared to the control, with CIN+PPM achieving the greatest methane reduction (similar to monensin, the positive control). Specific essential oil combinations demonstrated synergistic effects in modulating rumen fermentation and reducing methane emissions, offering potential for sustainable livestock production. Further in vivo validation is required to optimize dosing and assess long-term effects on animal performance. Full article
(This article belongs to the Special Issue Nutrients and Feed Additives in Ruminants)
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19 pages, 2624 KiB  
Article
The Modeling of Electromagnetic Behavior in the High-Frequency Range of Al2O3 and TiO2 Thermoplastic Composites in Support of Developing New Substrates for Flexible Electronics
by Radu F. Damian, Cristina Pachiu, Alexandra Mocanu, Alexandru Trandabat and Romeo Cristian Ciobanu
Crystals 2025, 15(7), 637; https://doi.org/10.3390/cryst15070637 - 10 Jul 2025
Viewed by 279
Abstract
The paper describes the simulation of energy absorption in polymer micro-composites that include dielectric inserts (commercial Al2O3 and TiO2 particles, with three particle sizes of 1, 5 and 25 µm, respectively). The investigated frequency spectrum, mainly from 0.001 to [...] Read more.
The paper describes the simulation of energy absorption in polymer micro-composites that include dielectric inserts (commercial Al2O3 and TiO2 particles, with three particle sizes of 1, 5 and 25 µm, respectively). The investigated frequency spectrum, mainly from 0.001 to 100 GHz, is designed for various uses as substrates in electronic technologies. The electromagnetic simulation software chosen was CST Studio Suite, which evaluates the power loss at different frequencies, playing a crucial role in creating the ideal structure of these substrates. The effective limits of the electromagnetic simulation are specified. It is shown that a considerable increase in absorption occurs, by a factor of 12 to 120, depending on the dielectric material used for the inserts and the mass ratio applied in the insertion technique. Dielectrics with high permittivity provide higher absorption, but also create a nonuniform field distribution within the material, resulting in a high peak-to-average absorption ratio. In scenarios where this behavior is intolerable, the technology must be carefully tuned to improve the consistency of the insertions in the substrate material. The final outcomes of the simulations indicated that for creating new substrates for flexible electronics, polyethylene composites with TiO2 insertions are suggested, particularly at lower concentrations of up to 7% and with a larger radius, such as 25 μm, which could offer significant economic advantages considering that the current concept advises the use of costly particles ranging from nanoscale particles to those 1 μm in size and a composition exceeding 10%. Full article
(This article belongs to the Section Hybrid and Composite Crystalline Materials)
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25 pages, 4876 KiB  
Article
“Metropolitan Parks” in Southern Barcelona: Key Nodes at the Intersection of Green Infrastructure and the Polycentric Urban Structure
by Joan Florit-Femenias, Carles Crosas and Aleix Saura-Vallverdú
Land 2025, 14(7), 1432; https://doi.org/10.3390/land14071432 - 8 Jul 2025
Viewed by 613
Abstract
Contemporary urban planning faces the ongoing challenge of developing Green Infrastructure capable of providing vital ecosystem services. Within this framework, the Barcelona metropolitan area has advanced a network of parks that, while serving local neighborhoods, also aim for metropolitan relevance. This study offers [...] Read more.
Contemporary urban planning faces the ongoing challenge of developing Green Infrastructure capable of providing vital ecosystem services. Within this framework, the Barcelona metropolitan area has advanced a network of parks that, while serving local neighborhoods, also aim for metropolitan relevance. This study offers a forward-looking analysis of selected parks in the southern Llobregat River basin—an area shaped by historic villages and working-class settlements—to evaluate their contribution to both Green Infrastructure and the region’s polycentric structure. Building on previous landmark studies and multidisciplinary perspectives, the research examines eight parks through four spatial and scalar lenses, assessing their territorial role and accessibility, ecological connectivity, urban integration and permeability, and landscape design with both qualitative and quantitative data. Using a comparative framework alongside research-by-design methods tested in urban design studios, the research links analytical insights to design-based strategies. The outcome is a set of actionable guidelines aimed at enhancing local park performance, with broader implications for over 50 ‘Metropolitan Parks’ spread in more than 30 municipalities. These insights contribute to shaping a more integrated, livable, and resilient metropolitan region. Full article
(This article belongs to the Section Land Planning and Landscape Architecture)
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15 pages, 1486 KiB  
Article
Assessment of Building Compactness at Initial Design Stage of Single-Family Houses
by Edwin Koźniewski
Energies 2025, 18(13), 3569; https://doi.org/10.3390/en18133569 - 7 Jul 2025
Viewed by 297
Abstract
The paper is the culmination of research on geometric aspects of assessing the energy demand of a single-family house. In a recent study, two collections of single-family houses were analyzed: (a) a collection of 21 with outlines assumed a priori so that the [...] Read more.
The paper is the culmination of research on geometric aspects of assessing the energy demand of a single-family house. In a recent study, two collections of single-family houses were analyzed: (a) a collection of 21 with outlines assumed a priori so that the building area was constant (which is not achievable in practice) and (b) a collection of 33 real buildings, recently designed by the Polish design studio Galeria Domów. These examples show the functioning of the indicators analyzed by the author in earlier papers and indicate the RCsq indicator that best reflects the assessment of building compactness in percentage points in relation to the ideal shape of the building plan, which is a square. The RCsq index is economically expressed by only two parameters, namely the base area Af and the building outline perimeter P, and therefore is easy to implement in the BIM system and at the same time covers high-rise buildings. As it turned out, the tested buildings from Galeria Domów have very good geometric and therefore energy efficiency. The above-mentioned indicator also highlights the advisability of analyzing the heated part in addition to the standard full-contour analyses. Full article
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16 pages, 3743 KiB  
Article
Evaluation of Different Housing Typologies with a Design Pedagogy
by Yalcin Yildirim, Elif Altas Cakil and Merve Ersoy
Architecture 2025, 5(3), 46; https://doi.org/10.3390/architecture5030046 - 30 Jun 2025
Viewed by 413
Abstract
Design studios generally concentrate on some critical concerns of urban life to overcome, and housing is one of those. Rapid development and advanced technology increase the need for and problems with housing. Such concerns should be addressed in theory, practice, and pedagogy. This [...] Read more.
Design studios generally concentrate on some critical concerns of urban life to overcome, and housing is one of those. Rapid development and advanced technology increase the need for and problems with housing. Such concerns should be addressed in theory, practice, and pedagogy. This study assesses the sophomores’ design output and their understanding of housing typologies based on real-world project sites to contribute to pedagogical aspects. Our study results show that students’ villa typologies generally focus on specific social groups with central themes, including health and recreation, while apartment complex designs converge on community life, urban identity, and tranquility. Based on the survey, students were part of it; they had difficulty with the scale and site-related grading problems, while most wished to work on the other typology theme. This study eventually calls attention to housing problems based on the design students’ perspectives on different residential typologies. Full article
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30 pages, 1033 KiB  
Article
Agile by Design: Embracing Resilient Built Environment Principles in Architectural and Urban Pedagogy
by Anosh Nadeem Butt, Ashraf M. Salama and Carolina Rigoni
Architecture 2025, 5(3), 45; https://doi.org/10.3390/architecture5030045 - 30 Jun 2025
Viewed by 981
Abstract
Climate change, urbanization, and socio-economic inequality are increasing the severity of urban challenges, emphasizing the imperative for a resilient built environment. Yet, architectural education has lagged in adopting resilience principles into its central curricula. This paper critiques dominant pedagogical paradigms and identifies shortcomings [...] Read more.
Climate change, urbanization, and socio-economic inequality are increasing the severity of urban challenges, emphasizing the imperative for a resilient built environment. Yet, architectural education has lagged in adopting resilience principles into its central curricula. This paper critiques dominant pedagogical paradigms and identifies shortcomings in interdisciplinary collaboration, digital tool adoption, and practical problem-solving. Moving its focus from local to international best practices for resilience, the study extracts key dimensions for learning architecture and explores case studies in leading schools that reflect pioneering, resilience-centric pedagogies. The findings highlight the importance of scenario-based learning, participatory design, and the use of technologies like AI, GIS, and digital twins to strengthen resilience. The article also explores how policy reformulation, accreditation mandates, and cross-sector collaborations can enforce the institutionalization of resilience education. It demands a pedagogical shift toward climate adaptation design studios, inter/transdisciplinary methods, and technological skills. The study ends with action guidelines for teachers, policymakers, and industry professionals who want to ensure that architectural education becomes responsive to resilient urban futures. Full article
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13 pages, 3040 KiB  
Article
Design and Development of Dipole Magnet for MIR/THz Free Electron Laser Beam Dumps and Spectrometers
by Ekkachai Kongmon, Kantaphon Damminsek, Nopadon Khangrang, Sakhorn Rimjaem and Chitrlada Thongbai
Particles 2025, 8(3), 66; https://doi.org/10.3390/particles8030066 - 25 Jun 2025
Viewed by 809
Abstract
This study presents the design and development of electromagnetic dipole magnets for use as beam dumps and spectrometers in the MIR and THz free-electron laser (FEL) beamlines at the PBP-CMU Electron Linac Laboratory (PCELL). The magnets were optimized to achieve a 60-degree bending [...] Read more.
This study presents the design and development of electromagnetic dipole magnets for use as beam dumps and spectrometers in the MIR and THz free-electron laser (FEL) beamlines at the PBP-CMU Electron Linac Laboratory (PCELL). The magnets were optimized to achieve a 60-degree bending angle for electron beams with energies up to 30 MeV, without requiring water cooling. Using CST EM Studio for 3D magnetic field simulations and ASTRA for particle tracking, the THz dipole (with 414 turns) and MIR dipole (with 600 turns) generated magnetic fields of 0.1739 T and 0.2588 T, respectively, while both operating at currents below 10 A. Performance analysis confirmed effective beam deflection, with the THz dipole showing that it was capable of handling beam energies up to 20 MeV and the MIR dipole could handle up to 30 MeV. The energy measurement at the spectrometer screen position was simulated, taking into account transverse beam size, fringe fields, and space charge effects, using ASTRA. The energy resolution, defined as the ratio of energy uncertainty to the mean energy, was evaluated for selected cases. For beam energies of 16 MeV and 25 MeV, resolutions of 0.2% and 0.5% were achieved with transverse beam sizes of 1 mm and 4 mm, respectively. All evaluated cases maintained energy resolutions below 1%, confirming the spectrometer’s suitability for high-precision beam diagnostics. Furthermore, the relationship between the initial and measured energy spread errors, taking into account a camera resolution of 0.1 mm/pixel, was evaluated. Simulations across various beam energies (10–16 MeV for the THz dipole and 20–25 MeV for the MIR dipole) confirmed that the measurement error in energy spread decreases with smaller RMS transverse beam sizes. This trend was consistent across all tested energies and magnet configurations. To ensure accurate energy spread measurements, a small initial beam size is recommended. Specifically, for beams with a narrow initial energy spread, a transverse beam size below 1 mm is essential. Full article
(This article belongs to the Special Issue Generation and Application of High-Power Radiation Sources 2025)
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29 pages, 4906 KiB  
Article
Ex Vivo Molecular Studies and In Silico Small Molecule Inhibition of Plasmodium falciparum Bromodomain Protein 1
by David O. Oladejo, Titilope M. Dokunmu, Gbolahan O. Oduselu, Daniel O. Oladejo, Olubanke O. Ogunlana and Emeka E. J. Iweala
Drugs Drug Candidates 2025, 4(3), 29; https://doi.org/10.3390/ddc4030029 - 21 Jun 2025
Viewed by 465
Abstract
Background: Malaria remains a significant global health burden, particularly in sub-Saharan Africa, accounting for high rates of illness and death. The growing resistance to frontline antimalarial therapies underscores the urgent need for novel drug targets and therapeutics. Bromodomain-containing proteins, which regulate gene expression [...] Read more.
Background: Malaria remains a significant global health burden, particularly in sub-Saharan Africa, accounting for high rates of illness and death. The growing resistance to frontline antimalarial therapies underscores the urgent need for novel drug targets and therapeutics. Bromodomain-containing proteins, which regulate gene expression through chromatin remodeling, have gained attention as potential targets. Plasmodium falciparum bromodomain protein 1 (PfBDP1), a 55 kDa nuclear protein, plays a key role in recognizing acetylated lysine residues and facilitating transcription during parasite development. Methods: This study investigated ex vivo PfBDP1 gene mutations and identified potential small molecule inhibitors using computational approaches. Malaria-positive blood samples were collected. Genomic DNA was extracted, assessed for quality, and amplified using PfBDP1-specific primers. DNA sequencing and alignment were performed to determine single-nucleotide polymorphism (SNP). Structural modeling used the PfBDP1 crystal structure (PDB ID: 7M97), and active site identification was conducted using CASTp 3.0. Virtual screening and pharmacophore modeling were performed using Pharmit and AutoDock Vina, followed by ADME/toxicity evaluations with SwissADME, OSIRIS, and Discovery Studio. GROMACS was used for 100 ns molecular dynamics simulations. Results: The malaria prevalence rate stood at 12.24%, and the sample size was 165. Sequencing results revealed conserved PfBDP1 gene sequences compared to the 3D7 reference strain. Virtual screening identified nine lead compounds with binding affinities ranging from −9.8 to −10.7 kcal/mol. Of these, CHEMBL2216838 had a binding affinity of −9.9 kcal/mol, with post-screening predictions of favorable drug-likeness (8.60), a high drug score (0.78), superior pharmacokinetics, and a low toxicity profile compared to chloroquine. Molecular dynamics simulations confirmed its stable interaction within the PfBDP1 active site. Conclusions: Overall, this study makes a significant contribution to the ongoing search for novel antimalarial drug targets by providing both molecular and computational evidence for PfBDP1 as a promising therapeutic target. The prediction of CHEMBL2216838 as a lead compound with favorable binding affinity, drug-likeness, and safety profile, surpassing those of existing drugs like chloroquine, sets the stage for preclinical validation and further structure-based drug design efforts. These findings are supported by prior experimental evidence showing significant parasite inhibition and gene suppression capability of predicted hits. Full article
(This article belongs to the Section In Silico Approaches in Drug Discovery)
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27 pages, 10012 KiB  
Article
Beam Emittance and Bunch Length Diagnostics for the MIR-FEL Beamline at Chiang Mai University
by Kittipong Techakaew, Kanlayaporn Kongmali, Siriwan Pakluea and Sakhorn Rimjaem
Particles 2025, 8(3), 64; https://doi.org/10.3390/particles8030064 - 21 Jun 2025
Viewed by 1120
Abstract
The generation of high-quality mid-infrared free-electron laser (MIR-FEL) radiation depends critically on precise control of electron beam parameters, including energy, energy spread, transverse emittance, bunch charge, and bunch length. At the PBP-CMU Electron Linac Laboratory (PCELL), effective beam diagnostics are essential for optimizing [...] Read more.
The generation of high-quality mid-infrared free-electron laser (MIR-FEL) radiation depends critically on precise control of electron beam parameters, including energy, energy spread, transverse emittance, bunch charge, and bunch length. At the PBP-CMU Electron Linac Laboratory (PCELL), effective beam diagnostics are essential for optimizing FEL performance. However, dedicated systems for direct measurement of transverse emittance and bunch length at the undulator entrance have been lacking. This paper addresses this gap by presenting the design, simulation, and analysis of diagnostic stations for accurate characterization of these parameters. A two-quadrupole emittance measurement system was developed, enabling independent control of beam-focusing in both transverse planes. An analytical model was formulated specifically for this configuration to enhance emittance reconstruction accuracy. Systematic error analysis was conducted using ASTRA beam dynamics simulations, incorporating 3D field maps from CST Studio Suite and fully including space-charge effects. Results show that transverse emittance values as low as 0.15 mm·mrad can be measured with less than 20% error when the initial RMS beam size is under 2 mm. Additionally, quadrupole misalignment effects were quantified, showing that alignment within ±0.95 mm limits systematic errors to below 33.3%. For bunch length measurements, a transition radiation (TR) station coupled with a Michelson interferometer was designed. Spectral and interferometric simulations reveal that transverse beam size and beam splitter properties significantly affect measurement accuracy. A 6% error due to transverse size was identified, while Kapton beam splitters introduced additional systematic distortions. In contrast, a 6 mm-thick silicon beam splitter enabled accurate, correction-free measurements. The finite size of the radiator was also found to suppress low-frequency components, resulting in up to 10.6% underestimation of bunch length. This work provides a practical and comprehensive diagnostic framework that accounts for multiple error sources in both transverse emittance and bunch length measurements. These findings contribute valuable insight for the beam diagnostics community and support improved control of beam quality in MIR FEL systems. Full article
(This article belongs to the Special Issue Generation and Application of High-Power Radiation Sources 2025)
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24 pages, 14095 KiB  
Article
Embodied Learning in Architecture: A Design Studio Model Utilizing Extended Reality
by Jin Mi Lee
Buildings 2025, 15(13), 2158; https://doi.org/10.3390/buildings15132158 - 20 Jun 2025
Viewed by 471
Abstract
This study presents a novel pedagogical model for architectural education that integrates an extended-reality (XR) enhanced learning environment with embodied cognitive approaches. Addressing the limited application of technology-driven embodied experiences in architectural education and the lack of empirical studies assessing their effectiveness, this [...] Read more.
This study presents a novel pedagogical model for architectural education that integrates an extended-reality (XR) enhanced learning environment with embodied cognitive approaches. Addressing the limited application of technology-driven embodied experiences in architectural education and the lack of empirical studies assessing their effectiveness, this research examines how an XR-integrated design studio model facilitates ideation, design development, and reflective practice. Using an action-research methodology over 15 weeks, the study involved 12 third-year architecture students divided into experimental and control groups. The first two stages assessed the model’s impact on time management, decision-making, and students’ sense of ownership in the design process, while the third and fourth stages evaluated the quality of design outcomes, creativity, presentation skills, and overall student satisfaction. The findings demonstrate that an embodied cognition-based XR learning environment significantly enhances students’ experiential understanding of design proposals, encourages active exploration of design alternatives, and supports problem-solving within the architectural design process. The model also improved decision-making and time management by enabling students to comprehensively experience and evaluate their proposals. This study highlights the pedagogical value of integrating embodied cognition principles with immersive digital environments in architectural education and provides a structured framework for leveraging emerging technologies to enhance creativity and innovation in design studios. Full article
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