Search Results (4,295)

Eosinophils are innate immune cells that infiltrate tissues in response to cell proliferation and necrosis, which occurs during normal injury repair, parasitic infections, allergies, and cancer. Their involvement in cancer is controversial particularly with regard to tumor-associated tissue eosinophilia (TATE) and a recently defined mechanism of extracellular trap cell death (ETosis), a particular type of eosinophil cell death that is distinct from both apoptosis and necrosis. This narrative review synthesizes the literature regarding the prognostic significance of TATE, focusing on eosinophil ETosis and the important role of transmission electron microscopy (TEM) in its detection and morphological characterization. The prognostic role of TATE is contradictory: in certain tumors, it is a favorable prognostic marker, while in others, it is unfavorable. However, recent research reveals that TATE is associated with a better prognosis in non-viral neoplasms, but it may correlate with a poor prognosis in virus-related neoplasms, such as human T-lymphotropic virus type 1 (HTLV-1)-associated lymphomas and HPV-positive carcinomas. Our ultrastructural investigations revealed distinct phases of eosinophil ETosis in gastric cancer, which were defined by chromatin decondensation, plasma membrane disruption, granule discharge, and development of extracellular traps. We observed synapse-like interactions between eosinophils, exhibiting ETosis or compound exocytosis, and tumor cells, which showed various degrees of cellular damage, ultimately leading to colloid-osmotic tumor cell death. TEM provides important insights into eosinophil-mediated cytotoxicity, requiring further investigation as potential immune effector mechanisms in non-viral tumors. TATE evaluation, together with the viral status of the neoplasia, may be useful to confirm its prognostic significance and consequently its therapeutic implication in specific cancers. Full article

The analysis of time-resolved S₁–S_n absorption spectra in the 0–500 ps range, together with quantum-chemical calculations, uncovered a photorecoordination reaction for the following complexes of CD6 (a bis(aza-18-crown-6)-containing dienone (ketocyanine dye) with a central cyclohexanone fragment): CD6·(Mⁿ⁺)₂ (M = Ba²⁺, Sr²⁺, Ca²⁺, K⁺). This process takes place over hundreds of fs and involves an “axial-to-equatorial” conformational change, with the solvation shell undergoing rearrangement as well. The characteristic photorecoordination times were found to correlate with the stability constants of the complexes. The lifetimes for the fluorescent states of CD6 and its complexes, namely CD6·(Mⁿ⁺)₂ (M = Ba²⁺, Sr²⁺, Ca²⁺, K⁺), are different; ergo, there is no photoejection of crowned cations into the solution. The calculated conformational profiles in the ground and excited states indicate the presence of an energy barrier in this process. A general photorelaxation pathway is suggested for CD6·(Mⁿ⁺)₂ metal complexes (M = Ba²⁺, Sr²⁺, Ca²⁺, K⁺). The coordination of cations via the carbonyl moiety in the dye molecule promotes photorecoordination of metal cations in the cavities of the azacrown ether fragment. Photorecoordination times were found to correlate with the degree of conjugation between the lone pairs in the N atoms of the aza-18-crown-6 ether and the π subsystem in the dye molecules (established for the CD4–CD6 metal–dye complex series, where CD4 and CD5 are related dyes with central cyclobutanone and cyclopentanone fragments, respectively). Full article

Introduction: Occupational allergic rhinitis (OAR) is a common respiratory condition that can lead to varying degrees of symptom severity, significantly impacting workers’ quality of life and productivity. While occupational risk factors are well established, the influence of nonoccupational factors, such as obesity, that contribute to OAR severity remains largely unexplored. Aims: This study aims to study the association between obesity and the severity of OAR. Methods: A cross-sectional analytical study was conducted among patients diagnosed with OAR at the Occupational Medicine Department of Farhat Hached University Hospital of Sousse. It combines a retrospective review of medical records (2013–2021) with prospective structured telephone interviews (January–March 2023). Data were collected from medical records and supplemented with telephone interviews. The severity of OAR was assessed via the PAREO score and rhinomanometry results. Results: A total of 196 patients were included. The mean age was 39.69 ± 7.92 years, with a sex ratio of 0.53. The most frequently reported symptoms were nasal obstruction (78.6%) and sneezing (88.8%). The mean PAREO score was 5.78 ± 1.61, with severe OAR reported in 59.2% of the patients. Obesity was significantly associated with increased severity of OAR symptoms (p < 0.001; OR = 5.4; 95% CI [2.6–11.1]), a finding confirmed after adjustment for variables such as age, sex, and occupational seniority. Conclusion: Obesity appears to be a modifiable risk factor influencing OAR severity. Integrating weight management strategies into the treatment of OAR patients may contribute to significant symptom relief and improved quality of life. Further longitudinal studies are needed to confirm these findings and explore the underlying mechanisms involved. Full article

Red mud, a by-product of aluminum production, leads to significant environmental challenges due to its alkalinity and presence of soluble compounds. This study explores its valorization through agglomeration with blast furnace sludge as a reducing agent to form self-reducing briquettes. Five C/Fe₂O₃ ratios (0.131, 0.262, 0.523, 0.840 and 1.000) were tested to determine the most effective reducing condition, with 0.840 emerging as optimal based on thermal analysis (mass loss of 27.44 wt.% at 1200 °C and iron formation specific energy of 450 J g⁻¹). Briquettes prepared with three agglomeration methods varying in water content (water/starch ratios of 6:1, 12:1 and 18:1) were evaluated through drop, compression and abrasion tests. The agglomeration method with a 12:1 water/solid ratio, involving both starch gelatinization and red mud water absorption, produced the most mechanically resistant briquettes (19.210 MPa). The mechanical and metallurgical properties of the 0.840-2W briquettes after reduction at 700, 950, 1200 and 1450 °C (temperature maintenance for 15 min) were assessed to define the best compromise between the reduction degree and mechanical strength. While reduction at 950 °C led to the weakest structure (0.449 MPa) but poor metallization, 1450 °C ensured the highest degree of reduction (94%) with adequate brittleness to facilitate a possible subsequent magnetic separation. Full article

In order to address the significant nonlinear dynamic characteristics and limited trajectory tracking accuracy of unmanned vehicles under cornering conditions, this paper proposes a trajectory tracking control strategy based on Adaptive Model Predictive Control (AMPC). First, to enhance the accuracy of the vehicle model, an 11-degree-of-freedom vehicle dynamics model is established, incorporating pitch, roll, yaw, rotation around the Z-axis, and wheel-axis rotation. The vehicle motion equations are derived using Lagrangian analytical mechanics. Meanwhile, the tire model is optimized by accounting for the influence of vehicle attitude changes on tire mechanical properties. Based on the principles of nonlinear model predictive control (NMPC) and adaptive control, the AMPC algorithm is developed, its prediction model is constructed, and appropriate control constraints are defined to ensure improved accuracy and stability in trajectory tracking. Finally, simulations under double-lane-change and serpentine driving conditions are conducted using a co-simulation platform involving Carsim and Matlab/Simulink. The results demonstrate that the proposed controller achieves high trajectory tracking accuracy, effectively suppresses vehicle yaw, pitch, and roll motions, and enhances both the smoothness of trajectory tracking and the overall dynamic stability of the vehicle. Full article

Known attacks on the tropical implementation of Stickel protocol involve finding minimal covers for a certain covering problem, and this leads to an exponential growth in the worst case time required to recover the secret key as the used polynomial degree increases. The computational inefficiency of this attack is also observed in practice, unless the number of explored covers is limited, on the expense of the success rate of the attack. Consequently, it can be argued that Alice and Bob can still repel these attacks on tropical Stickel protocol by utilizing very high polynomial degrees, a feasible approach due to the efficiency of tropical operations. The same is true for the implementation of Stickel protocol over some other semirings with idempotent addition (such as the max–min or digital semiring). In this paper, we propose alternative methods to attack the Stickel protocols that avoid solving the covering problem. These methods involve framing the attacks as a mixed integer linear programming (MILP) problem or applying certain heuristic global optimization techniques. We also include a number of numerical experiments to analyze the success rate and the time required to execute the suggested attacks in practice. Full article

Terminal forensics in large mobile networks is a vital activity for identifying compromised devices and analyzing malicious actions. In contrast, the study described here begins with the domain of terminal forensics as the primary focus, rather than the threat itself. This paper proposes a new multi-criteria decision-making (MCDM) model that integrates complex picture fuzzy sets (CPFS) with the combinative distance-based assessment (CODAS), referred to throughout as complex picture fuzzy CODAS (CPF-CODAS). The aim is to assist in forensic analysis for detecting mobile botnet command and control (C&C) systems. The CPF-CODAS model accounts for the uncertainty, hesitation, and complex numerical values involved in expert decision-making, using degrees of membership as positive, neutral, and negative values. An illustrative forensic case study is constructed where three mobile devices are evaluated by three cybersecurity professionals based on six key parameters related to botnet activity. The results demonstrate that the model can effectively distinguish suspicious devices and support the use of the CPF-CODAS approach in terminal forensics of mobile networks. The robustness, symmetry, and advantages of this model over existing MCDM methods are confirmed through sensitivity and comparison analyses. In conclusion, this paper introduces a novel probabilistic decision-support tool that digital forensic specialists can incorporate into their workflow to proactively identify and prevent actions of mobile botnet C&C servers. Full article

Background: Dementia is a progressive neurodegenerative condition that impairs cognitive functions such as memory, language comprehension, and problem-solving. Assistive technologies can provide vital support at various stages of dementia, significantly improving the quality of life by aiding daily activities and care. However, for these technologies to be effective and widely adopted, a human-centred design (HCD) approach is of consequence for both their development and evaluation. Objectives: This scoping review aims to explore how HCD principles have been applied in the design of assistive technologies for people with dementia and to identify the extent and nature of their involvement in the design process. Eligibility Criteria: Studies published between 2017 and 2025 were included if they applied HCD methods in the design of assistive technologies for individuals at any stage of dementia. Priority was given to studies that directly involved people with dementia in the design or evaluation process. Sources of Evidence: A systematic search was conducted across five databases: Web of Science, JSTOR, Scopus, and ProQuest. Charting Methods: Articles were screened in two stages: title/abstract screening (n = 350) and full-text review (n = 89). Data from eligible studies (n = 49) were extracted and thematically analysed to identify design approaches, types of technologies, and user involvement. Results: The 49 included studies covered a variety of assistive technologies, such as robotic systems, augmented and virtual reality tools, mobile applications, and Internet of Things (IoT) devices. A wide range of HCD approaches were employed, with varying degrees of user involvement. Conclusions: HCD plays a critical role in enhancing the development and effectiveness of assistive technologies for dementia care. The review underscores the importance of involving people with dementia and their carers in the design process to ensure that solutions are practical, meaningful, and capable of improving quality of life. However, several key gaps remain. There is no standardised HCD framework for healthcare, stakeholder involvement is often inconsistent, and evidence on real-world impact is limited. Addressing these gaps is crucial to advancing the field and delivering scalable, sustainable innovations. Full article

The research in this paper aims to analyze the perception and degree of involvement of employees from a Romanian shipyard in the process of preparing sustainability reports, with a focus on the integration of ESG criteria into organizational performance. The motivation for this study is to understand how directly productive employees within a shipyard see the usefulness of improving sustainability performance by integrating ESG criteria. To conduct this research, the authors used a survey-based analysis method, which was carried out using a questionnaire. This was sent online to target employees, and the defined hypotheses were validated based on the results obtained using IBM SPSS Statistics 22 statistical analysis software. The statistical results have shown that the employees in the analyzed departments perceive the importance of measuring, monitoring, and reporting sustainability performance in the company’s value chain. The originality of the work lies in the fact that this is the first study of its kind to be carried out within a shipyard in our country, with direct implications for the development of future sustainability reports. Full article

Obstruction differential diagnosis involves tumors, “acute abdomen”, and chronic pseudo-obstruction (CIPO). Pediatric CIPO cases have different backgrounds than adults’ and impairs development. The cases are rare; diagnosis and treatment are still not well established. Diagnosis is complex; clinical, radiological, molecular, and manometric pathologic data are essential. The performance of broad radiological investigations and manometry is cumbersome in a small intestine. Herein, we present cases of a 14-year-old girl and 11-year-old boy with visceral myopathies (VMs). Presented cases show unique hardship in the analysis of standing and contrast bedside X-ray images—the colon distension alone speaks to Hirschsprung, and the clinicians could not confirm suspected short-segment disease for a long time. VMs are usually diagnosed up to 12 months of life and accompanied by other organ dysfunctions, which are herein absent. The key features here were also the involvement of the small intestine, lack of distant colon contraction, and for the long-lasting case in the boy, loss of haustration. The initial diagnosis relied on clinical data (vomiting, malabsorption, >6-month obstruction, and uncharacteristic biochemical tests), radiology (lack of tumor, enlargement of diameter, and fluid in small and large intestines), and manometry (presence of propagation wave and of anal inhibitory reflex in recto–anal manometry). Examination of intestinal muscle biopsies involved hematoxylin-eosin, trichrome-Masson staining, and immunohistochemistry. The characteristics were fibrosis, small vacuoles, muscle layer thinning, and decreased expression of smooth muscle actin and desmin. The localization of biopsies was chosen after X-ray examination, due to interruption and with various degree changes. The final diagnosis was put forward after the analysis of all accessible data. The diagnosis of VM underlines the importance of interdisciplinary co-work. An earlier intestine muscle biopsy and well-designed molecular panel might fasten the process of diagnosis. Deeper exploration of phenotype–genotype correlation of various VM presentations in the future is crucial for personalized treatment. Full article

Background/Objectives: Wilson’s disease (WD) is an autosomal recessive disorder characterized by pathological copper accumulation, primarily in the liver and brain. Severe hepatic involvement can be effectively treated with liver transplantation (LT). Geographic variation in ATP7B mutations suggests the presence of regional patterns that may impact disease presentation and management. This study aims to investigate the genetic basis of WD in patients from a major LT center in Iran. Methods: A retrospective analysis was conducted on clinical, biochemical, and pathological data from patients suspected of WD who underwent evaluation for LT between May 2020 and June 2025 at Shiraz University of Medical Sciences. Genetic testing was carried out on 20 patients at the Shiraz Transplant Research Center (STRC). Direct mutation analysis of ATP7B was performed for all patients, and the results correlated with clinical and demographic information. Results: In total, 20 WD patients who underwent liver transplantation (15 males, 5 females) carried 25 pathogenic or likely pathogenic ATP7B variants, 21 of which were previously unreported. Fifteen patients were homozygous, and five were compound-heterozygous; all heterozygous combinations occurred in the offspring of second-degree consanguineous unions. Recurrent changes included p.L549V, p.V872E, and p.P992S/L, while two nonsense variants (p.E1293X, p.R1319X) predicted truncated proteins. Variants were distributed across copper-binding, transmembrane, phosphorylation, and ATP-binding domains, and in silico AlphaMissense scores indicate damaging effects for most novel substitutions. Post-LT follow-up showed biochemical normalization in the majority of recipients, with five deaths recorded during the study period. Conclusions: This single-center Iranian study reveals a highly heterogeneous ATP7B mutational landscape with a large proportion of novel population-specific variants and underscores the benefit of comprehensive gene sequencing for timely WD diagnosis and family counseling, particularly in regions with prevalent consanguinity. Full article

The study presents the results of investigations into various types of anhydrous pyrolysis aimed at determining the kinetic parameters of hydrocarbon generation processes from source rocks. Surface outcrop samples from the Silesian, Dukla, and Skole units, characterized by a low level of thermal maturity, were used as experimental material. The samples predominantly represented the Menilite Beds from the aforementioned three units, but also included Istebna, Lgota, Verovice, and Spas beds, which exhibit significantly lower parameters that describe generation properties. The anhydrous pyrolysis experiments provided information on the rate of organic matter decomposition (TG/DSC), the degree of conversion (Rock-Eval), the quality of the obtained products (Py/GC), and the isotopic composition of the gaseous products (Py/GC/IRMS). Chromatographic analyses confirmed the oil-prone nature of kerogen contained in the Menilites from the Dukla Unit (Tylawa area), the Silesian Unit (Iwonicz fold), and the Skole Unit, revealing an equal share of all hydrocarbon fractions: C₁–C₉, C₁₀–C₁₅, and C₁₅₊. Through the integration of pyrolytic studies conducted on potential source rocks in the polish Outer Carpathians, a new type of information was obtained regarding the rate of organic matter decomposition, as well as the fractional and isotopic composition of the pyrolysis products. The set of obtained results was used to estimate the activation energy and characterize the potential source levels. The innovative aspect of this approach involved the isotopic characterization of gaseous products generated during thermal degradation of the source rocks. These data were subsequently used to establish genetic correlations with natural gases accumulated in hydrocarbon reservoirs of the Carpathian region. It has been demonstrated that pyrolysis using PY-GC-IRMS can yield results comparable to those obtained through generation in natural geological conditions. Full article

This study presents the design and evaluation of a dexterous prosthetic hand featuring five fingers, ten independently actuated joints, and four passively driven joints. The hand’s dexterity is enabled by a novel rigid–flexible coupled finger mechanism that incorporates a 1-active–1-passive joint configuration, which can enhance the dexterity of traditional rigid actuators while achieving a human-like workspace. Each finger is designed with a specific degree of rotational freedom to mimic natural opening and closing motions. This study also elaborates on the mapping of eight-channel electromyography to finger grasping force through improved TCN, as well as the control algorithm for grasping flexible objects. A functional prototype of the prosthetic hand was fabricated, and a series of experiments involving adaptive grasping and handheld manipulation tasks were conducted to validate the effectiveness of the proposed mechanical structure and control strategy. The results demonstrate that the hand can stably grasp flexible objects of various shapes and sizes. This work provides a practical solution for prosthetic hand design, offering promising potential for developing lightweight, dexterous, and highly anthropomorphic robotic hands suitable for real-world applications. Full article

Objectives: The process of social rehabilitation involves several stages, from assessing an individual’s condition and determining their potential for rehabilitation to implementing a personalized plan with continuous monitoring of progress. Advances in information technology, including artificial intelligence, enable the use of software-assisted solutions for objective assessments and personalized rehabilitation strategies. The research aims to present interconnected semantic models that represent expandable knowledge in the field of rehabilitation, as well as an integrated framework and methodology for constructing virtual assistants and personalized decision support systems based on these models. Materials and Methods: The knowledge and data accumulated in these areas require special tools for their representation, access, and use. To develop a set of models that form the basis of decision support systems in rehabilitation, it is necessary to (1) analyze the domain, identify concepts and group them by type, and establish a set of resources that should contain knowledge for intellectual support; (2) create a set of semantic models to represent knowledge for the rehabilitation of patients. The ontological approach, combined with the cloud cover of the IACPaaS platform, has been proposed. Results: This paper presents a suite of semantic models and a methodology for implementing decision support systems capable of expanding rehabilitation knowledge through updated regulatory frameworks and empirical data. Conclusions: The potential advantage of such systems is the combination of the most relevant knowledge with a high degree of personalization in rehabilitation planning. Full article

The germination, seedling growth, and crop productivity of maize seeds are significantly impacted by seed aging. This study investigated the efficacy of silver nanoparticles (AgNPs) as a seed priming agent for maize inbred lines exhibiting varying degrees of aging tolerance. Two inbred lines, aging-sensitive I178 and aging-tolerant X178, were used. AgNP treatment significantly promoted the germination of I178 (from 55% to 85%, compared with water treatment). Notable improvements were observed in root length, shoot length, and lateral root formation after AgNP treatment in I178. However, X178 showed no significant changes in germination and seedling growth after the AgNP treatment. Further transcriptomic analysis was performed on X178 and I178 before (water treatment) and after AgNP treatment to study genes and the expression network of the mechanism induced by AgNP promotion. In I178, AgNP treatment led to a substantial increase in differentially expressed genes (DEGs). A total of 800 DEGs were identified, with 517 being upregulated and 283 downregulated. The DEGs in I178 were mainly involved in metabolic processes, stress responses, and membrane repair. For example, genes related to lipid metabolism and membrane integrity were upregulated, along with seven genes associated with antioxidant action and redox metabolism. This indicates that AgNPs might enhance membrane stability and stress tolerance in I178. In contrast, X178 had a limited transcriptomic response to AgNP treatment. Although 874 DEGs were detected, the number of genes related to key processes like those in I178 did not change significantly, which is in line with its inherent aging tolerance. Overall, these results suggest that AgNPs can effectively improve seed vigor and counteract the negative effects of seed aging, especially in aging-sensitive maize lines. The mechanism likely occurs through regulating gene expression related to stress response, metabolic repair, and membrane stability. This study provides new insights into the molecular basis of AgNP-mediated seed vigor enhancement, which has potential implications for improving seed quality in agricultural production. Full article