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11 pages, 235 KB  
Article
Descriptive Survey of Firearm Storage Practices Among Families in the Emergency Department Before and After Jaelynn’s Law in Baltimore
by Joanna S. Cohen, Priyal Patel, Katherine Hoops, Amie Bettencourt and Leticia Manning Ryan
Trauma Care 2026, 6(2), 7; https://doi.org/10.3390/traumacare6020007 - 6 Apr 2026
Viewed by 563
Abstract
Background: Firearm injuries are the leading cause of mortality among youth in the United States and legislation is a key strategy in reducing youth firearm injuries and deaths. Maryland recently enacted a stronger child access prevention (CAP) law known as Jaelynn’s Law, which [...] Read more.
Background: Firearm injuries are the leading cause of mortality among youth in the United States and legislation is a key strategy in reducing youth firearm injuries and deaths. Maryland recently enacted a stronger child access prevention (CAP) law known as Jaelynn’s Law, which mandates secure firearm storage and imposes stricter penalties for violations. Objectives: The aim of this study was to examine firearm storage practices and beliefs in a pediatric and adult emergency department in Baltimore before and after the implementation of Jaelynn’s Law. Method: This descriptive study recruited 396 adult participants from pediatric and adult EDs at Johns Hopkins Hospital before and after the implementation of Jaelynn’s Law. Participants completed a survey on demographics, firearm ownership, and storage practices. Those with unsafe storage practices were provided educational pamphlets and safe storage devices. Data were analyzed using SPSS Statistics 28, with descriptive statistics, t-tests, and Chi-square analyses used to assess differences pre- and post-law implementation. Results: Of the participants, 29% owned firearms, with 86% of firearm owners having children in the home. Firearms were primarily stored locked and unloaded. No significant differences in storage practices were observed after implementation of Jaelynn’s Law. Participants cited quick access for personal protection as a key barrier to safe storage. Conclusions: We found no significant change in safe storage practices post-implementation of Jaelynn’s Law. Concerns about personal safety continue to be of primary concern and public health campaigns, legislative measures, and community investment are necessary to enhance safety and safe storage compliance. Full article
21 pages, 954 KB  
Article
Because I Could Stop for Death: Florida’s Death Row Prisoners in the 1960s and 1970s
by Vivien Miller
Histories 2025, 5(4), 55; https://doi.org/10.3390/histories5040055 - 14 Nov 2025
Viewed by 2739
Abstract
This article focuses on Florida’s death row in the 1960s and 1970s when executions stopped, even though juries continued to return capital verdicts for murder and (until 1977) rape. It first challenges the conventional wisdom surrounding the moratorium years as there were no [...] Read more.
This article focuses on Florida’s death row in the 1960s and 1970s when executions stopped, even though juries continued to return capital verdicts for murder and (until 1977) rape. It first challenges the conventional wisdom surrounding the moratorium years as there were no executions in Florida from mid-May 1964 until May 1979. It investigates the overlapping governor-initiated pauses, court-ordered postponements, and significant state and national court rulings in this period. This article then explores the experiences of male death row prisoners who were held in solitary confinement with limited human contact on a special wing in the Florida State Prison at Raiford, an often violent and unstable maximum-security state prison. Prior to the Furman v. Georgia (1972) U.S. Supreme Court decision, capital prisoners in Florida waited for up to twelve years for courts and politicians to make crucial death penalty decisions. Death row conditions declined as the number of penalized bodies increased threefold between 1963 and 1972. However, Florida’s death row also became a crucial political, social, and cultural space in which some prisoners directly challenged the biopower of the state prison system, by submitting hand-written legal appeals, offering to participate in military service and medical-scientific research, and engaging in collective petitioning and hunger strike. Full article
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20 pages, 1258 KB  
Article
The Crime of Vehicular Homicide in Italy: Trends in Alcohol and Drug Use in Fatal Road Accidents in Lazio Region from 2018 to 2024
by Francesca Vernich, Leonardo Romani, Federico Mineo, Giulio Mannocchi, Lucrezia Stefani, Margherita Pallocci, Luigi Tonino Marsella, Michele Treglia and Roberta Tittarelli
Toxics 2025, 13(7), 607; https://doi.org/10.3390/toxics13070607 - 19 Jul 2025
Viewed by 3746
Abstract
In Italy, the law on road homicide (Law no. 41/2016) introduced specific provisions for drivers who cause severe injuries or death to a person due to the violation of the Highway Code. The use of alcohol or drugs while driving constitutes an aggravating [...] Read more.
In Italy, the law on road homicide (Law no. 41/2016) introduced specific provisions for drivers who cause severe injuries or death to a person due to the violation of the Highway Code. The use of alcohol or drugs while driving constitutes an aggravating circumstance of the offence and provides for a tightening of penalties. Our study aims to report on the analysis performed on blood samples collected between January 2018 and December 2024 from drivers convicted of road homicide and who tested positive for alcohol and/or drugs. The majority of the involved subjects were males belonging to the 18–30 and 41–50 age groups. Alcohol, cocaine and cannabinoids were the most detected substances and the most frequent polydrug combination was alcohol and cocaine. We also investigated other influencing factors in road traffic accidents as the day of the week and the time of the day in which fatal road traffic accident occurred, and the time elapsed between the road accident and the collection of biological samples. Our data, in line with the international scenario, strongly support that, in addition to the tightening of penalties, raising awareness plays a key role in preventing alcohol- and drug-related traffic accidents by increasing risk perception and encouraging safer driving behaviors. Full article
(This article belongs to the Special Issue Current Issues and Research Perspectives in Forensic Toxicology)
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15 pages, 576 KB  
Article
Introducing the Women’s Execution Database: Revising the Narrative of Gender and Executions with Empirical Evidence
by Corina Schulze
Sexes 2025, 6(2), 27; https://doi.org/10.3390/sexes6020027 - 7 Jun 2025
Viewed by 3487
Abstract
The Death Penalty Information Center’s (DPIC) website states that, since 1608, 576 executions of women under civil authority have been carried out in the United States. The “Espy file”, cited by the DPIC, is widely considered to be the definitive dataset of all [...] Read more.
The Death Penalty Information Center’s (DPIC) website states that, since 1608, 576 executions of women under civil authority have been carried out in the United States. The “Espy file”, cited by the DPIC, is widely considered to be the definitive dataset of all executions occurring between 1608 and 2002, but only lists about 365 executions of women. The following two major empirical contributions are offered: (1) source verification of the Espy file, suggesting that black women are especially undercounted and that the total number of executions is closer to 700, and (2) the provision of descriptive statistics demonstrating the variability of women’s to men’s execution ratios over time. This study’s primary purpose is the release and publication of a working dataset, the Women’s Execution Database (WEB), which is meant to generate interest in constructing a narrative that validates the importance of gender-focused theories requiring variables that represent gendered experiences with the death penalty. One example of how such a database can verify women’s erasure in mainstream discussions of capital punishment are WEB statistics demonstrating that active resistance to slavery and racism is verifiable via empirical evidence. Full article
(This article belongs to the Section Gender Studies)
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32 pages, 3256 KB  
Article
Analyzing the Successful Incompetent to Be Executed Cases in the United States: A First Pass
by I-An Su, John H. Blume and Stephen J. Ceci
Behav. Sci. 2025, 15(3), 325; https://doi.org/10.3390/bs15030325 - 6 Mar 2025
Cited by 2 | Viewed by 4404
Abstract
More than three decades ago, the Supreme Court of the United States (SCOTUS) ruled that individuals who are not competent (alternatively referred to by the Court as insane) at the time of their scheduled execution cannot be put to death. Despite the years [...] Read more.
More than three decades ago, the Supreme Court of the United States (SCOTUS) ruled that individuals who are not competent (alternatively referred to by the Court as insane) at the time of their scheduled execution cannot be put to death. Despite the years that have passed since the Court’s decision and the literal life-or-death stakes involved, competency for execution (CFE) remains underexplored in the psychological, psychiatric, and legal literature. A number of important legal and ethical issues that arise when a person on death row maintains they are not competent to be executed are still unresolved even after the landmark Supreme Court cases such as Ford v. Wainwright (1986), Panetti v. Quarterman (2007), and Madison v. Alabama (2019). In this first-of-its-kind descriptive study, we analyzed the demographic and case characteristics of the 28 successful Ford claimants—individuals in the United States who have been found to be incompetent to be executed and compared them to the general death row population and homicide cases nationwide. Our findings reveal some similarities but also some differences between these claimants and the general death row population and homicide cases: the successful Ford claimants are exclusively male (in keeping with the general prison population on death row), relatively older, and underrepresented among White and Latinx inmates (i.e., Black claimants are more successful than their White and Latinx counterparts at evading execution). Nearly all (96%) suffer from schizophrenia, with 79% experiencing psychiatric comorbidity, yet only 54% received any significant treatment before or after the criminal offense. The claimants’ cases also involve a higher proportion of child victims, male family members, and female non-family member victims, as well as more multiple-victim cases (not indiscriminate) and fewer intraracial homicides. Fewer victims are male, and more are female. However, the cases do not align with typical male-on-male violent crimes or femicide patterns, such as those involving sexual or domestic violence. Additionally, systematic psycho-legal deficiencies are prevalent, including a low rate of mental health evidence (61%) presented at trials and some cases lacking psychiatric involvement in CFE evaluations. Temporal influence and drastic state variations on CFE evaluation are also noted. Although the small sample size limits generalizability, this small-scale descriptive study offers a number of important insights into the complexities of CFE decisions and lays the groundwork for future research and policy development. Full article
(This article belongs to the Special Issue Social Cognitive Processes in Legal Decision Making)
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13 pages, 1212 KB  
Article
Clean Air Benefits and Climate Penalty: A Health Impact Analysis of Mortality Trends in the Mid-South Region, USA
by Chunrong Jia, Hongmei Zhang, Namuun Batbaatar, Abu Mohd Naser, Ying Li and Ilias Kavouras
Climate 2025, 13(3), 45; https://doi.org/10.3390/cli13030045 - 22 Feb 2025
Cited by 1 | Viewed by 3394
Abstract
The lowering air pollution in the US has brought significant health benefits; however, climate change may offset the benefits by increasing the temperature and worsening air quality. This study aimed to estimate the mortality changes due to air pollution reductions and evaluate the [...] Read more.
The lowering air pollution in the US has brought significant health benefits; however, climate change may offset the benefits by increasing the temperature and worsening air quality. This study aimed to estimate the mortality changes due to air pollution reductions and evaluate the potential climate penalty in the Mid-South Region of the US. Daily concentrations of PM2.5 and ozone measured at local monitoring stations in 1999–2019 were extracted from the US Environmental Protection Agency’s Air Quality System. Meteorological data for the same period were obtained from the National Oceanic and Atmospheric Administration’s Local Climatological Data. Annual average age-adjusted all-cause mortality rates (MRs) were downloaded from the US Centers for Disease Control and Prevention’s WONDERS Databases. MRs attributable to exposure to PM2.5, ozone, and high temperatures in warm months were estimated using their corresponding health impact functions. Using Year 1999 as the baseline, contributions of environmental changes to MR reductions were calculated. Results showed that annual average concentrations of PM2.5 and ozone decreased by 46% and 23% in 2019, respectively, compared with the base year; meanwhile, the mean daily temperature in the warm season fluctuated and displayed an insignificant increasing trend (Kendall’s tau = 0.16, p = 0.30). MRs displayed a significant decreasing trend and dropped by 215 deaths/100,000 person-year in 2019. Lower PM2.5 and ozone concentrations were estimated to reduce 59 and 30 deaths/100,000 person-year, respectively, contributing to 23% and 17% of MR reductions, respectively. The fluctuating temperatures had negligible impacts on mortality changes over the two-decade study period. This study suggests that improved air quality may have contributed to mortality reductions, while the climate penalty effects appeared to be insignificant in the Mid-South Region. Full article
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13 pages, 230 KB  
Article
The New Moral Absolutism in Catholic Moral Teaching: A Critique Based on Veritatis Splendor
by Károly Mike
Religions 2025, 16(2), 149; https://doi.org/10.3390/rel16020149 - 28 Jan 2025
Viewed by 4256
Abstract
This paper examines a recent shift in Catholic moral teaching, characterized by the emergence of a ‘new moral absolutism’, in which certain acts traditionally subject to prudential judgment—such as the death penalty, ecological harm, and restrictive migration policies—are increasingly portrayed as universally and [...] Read more.
This paper examines a recent shift in Catholic moral teaching, characterized by the emergence of a ‘new moral absolutism’, in which certain acts traditionally subject to prudential judgment—such as the death penalty, ecological harm, and restrictive migration policies—are increasingly portrayed as universally and gravely wrong in our age. Simultaneously, traditional moral absolutes, especially in sexual and life ethics, have experienced cautious relativization. Drawing on the framework of Veritatis Splendor (1993), the paper critiques the approach of this new moral absolutism, arguing that it undermines the proper role of individual conscience and situational discernment while failing to provide coherent guidance on complex moral dilemmas. It links its emergence to proportionalist ethics: when traditional moral absolutes are relativized, new types of wrongs take their place. The paper proposes a return to the principles of Veritatis Splendor, advocating for a nuanced approach that preserves the constant and limited set of absolute negative norms and encourages the formation and use of conscience for all other matters. Full article
15 pages, 2015 KB  
Article
Quantification of the Survival Disadvantage Associated with Major Amputation in Patients with Peripheral Arterial Disease
by Maria Elisabeth Leinweber, Emanuel Greistorfer, Julia Rettig, Fadi Taher, Miriam Kliewer, Afshin Assadian and Amun Georg Hofmann
J. Clin. Med. 2025, 14(1), 104; https://doi.org/10.3390/jcm14010104 - 27 Dec 2024
Cited by 6 | Viewed by 4186
Abstract
Objective: Despite advancements in vascular surgery, the mortality among peripheral arterial disease (PAD) patients undergoing major amputations remains high. While a large body of evidence has previously covered survival rates after major amputation, there is less evidence regarding the associated survival penalty [...] Read more.
Objective: Despite advancements in vascular surgery, the mortality among peripheral arterial disease (PAD) patients undergoing major amputations remains high. While a large body of evidence has previously covered survival rates after major amputation, there is less evidence regarding the associated survival penalty from an epidemiological perspective. The present analysis aimed at quantifying the survival disadvantage after major lower limb amputation while investigating which factors are associated with mortality in this patient cohort. Methods: Data from 246 PAD patients undergoing major amputations were retrospectively collected and matched with mortality records from the Austrian National Death Registry. Life expectancy was estimated using population-based life tables, and differences between observed and expected survival were analyzed across subgroups. Results: The median follow-up was 492 days (Q1–Q3: 73–1438), and 82.5% (n = 203) of patients died, with cardiovascular events being the leading cause (41%). A profound discrepancy between estimated (4697 days, Q1–Q3: 2962–6236) and observed survival (457 days, Q1–Q3: 73–1438, p < 0.001) was seen. In men, an associated median survival penalty of 11.2 years was observed, equivalent to a proportionate reduction in life expectancy of over 90%, while the difference in women was 8.7 years, equaling a reduction of 84.6%. In a multiple regression model, 1 year in life expectancy was associated with a survival penalty of −0.96 years, thereby affecting younger patients with the highest life expectancies the most. Conclusions: Major amputation in PAD patients is associated with a significant reduction in survival compared to standardized mortality rates in the general population. The survival disadvantage exceeds 70% of estimated survival times in over 70% of patients. Elevated mortality rates after major amputation in PAD patients should not be interpreted as a causal relationship but as a surrogate for impaired systemic cardiovascular health. Full article
(This article belongs to the Special Issue Vascular Surgery: Recent Developments and Emerging Trends)
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30 pages, 415 KB  
Article
Bahrain Forum for Dialogue Apostolic Journey of Pope Francis to Bahrain as a Step on the Path of Brotherhood Between Religions
by Aldona Piwko and Zofia Sawicka
Religions 2024, 15(12), 1569; https://doi.org/10.3390/rel15121569 - 23 Dec 2024
Cited by 1 | Viewed by 2102
Abstract
The article discusses Pope Francis’s visit to Bahrain in 2022, which, although religiously and politically important, has not yet been exposed to science. This is the second visit of the head of the Catholic Church to the countries of the Persian Gulf, which [...] Read more.
The article discusses Pope Francis’s visit to Bahrain in 2022, which, although religiously and politically important, has not yet been exposed to science. This is the second visit of the head of the Catholic Church to the countries of the Persian Gulf, which is part of the refreshing interreligious dialogue between Christians and Muslims. This article analyzes changes in the Catholic Church’s understanding of dialogue with Islam, as illustrated by Pope Francis’s visit to Bahrain. Using comparative analysis, the article highlights the evolving nature of interreligious dialogue and its role in strengthening Muslim–Christian connections. The papal visit to Bahrain caused much controversy among human rights activists. Bahrain is seen, on one hand, as a tolerant and religiously inclusive country, but on the other, as a nation that frequently violates human rights, particularly in cases involving differences among its members. Pope Francis, as a diplomat, was not afraid to talk about some social issues in Bahrain (death penalty, discrimination, labor law) from the beginning of his visit. Pope Francis’s attitude and the benefits of interreligious dialogue that he has generated may not only confirm the presence of Christians in Bahrain but, above all, must change their destiny in the countries of the region that have so far treated this religion as an enemy. This article is an analysis of sources and their systematic review. The authors have focused on the interpretation of Pope Francis’s statements and their reception in the world. Interreligious and intercultural dialogue, as well as interpersonal fraternities, are extremely important in the international policy of the Holy See. Full article
14 pages, 229 KB  
Article
The Post-Harmonisation Health and Safety Challenges of Construction Industry Managers
by Richard Phelps, Janis Jansz, Ping Chang and Apurna Ghosh
Safety 2024, 10(4), 98; https://doi.org/10.3390/safety10040098 - 24 Nov 2024
Cited by 1 | Viewed by 2381
Abstract
To minimise the occurrence of injuries, illnesses and deaths due to work-related causes, it is important to have effective workplace health safety legislation that is known and used. The introduction of more stringent workplace health and safety legislation across Australia has brought greater [...] Read more.
To minimise the occurrence of injuries, illnesses and deaths due to work-related causes, it is important to have effective workplace health safety legislation that is known and used. The introduction of more stringent workplace health and safety legislation across Australia has brought greater responsibility, and harsher penalties, for managers. The importance of the role those in management play in influencing and shaping a culture of safety is well researched, but little has been done to determine whether those in management are ready to assume that role. This study aimed to identify what has informed Western Australian construction industry managers who are working within the mining sector and ultimately shaped their approach to occupational health and safety. NVivo software was used to analyse the data by the creation of codes and subcodes to identify themes and subthemes. Analysis of two focus groups’ participants’ responses identified that many managers had insufficient work health and safety education to understand their obligations and that other challenges include insufficient preparedness of managers, particularly newly promoted supervisors and other management staff, rapid promotion, and the bureaucracy of modern workplace health and safety. The findings from this study can assist organisations to better prepare managers to fulfil their workplace health and safety obligations and reduce some of the post-harmonisation challenges. Full article
23 pages, 845 KB  
Systematic Review
Explaining Gender Neutrality in Capital Punishment Research by Way of a Systematic Review of Studies Citing the ‘Espy File’
by Corina Schulze
Sexes 2024, 5(4), 521-543; https://doi.org/10.3390/sexes5040036 - 12 Oct 2024
Cited by 1 | Viewed by 3522
Abstract
Peer-reviewed journal articles provide the data for this study, given that their findings undergird the quantitative data referenced by prominent organizations, courts, and policy-makers. The “Espy file”, based on the research of Major Watt Espy, Jr., is used to identify studies due to [...] Read more.
Peer-reviewed journal articles provide the data for this study, given that their findings undergird the quantitative data referenced by prominent organizations, courts, and policy-makers. The “Espy file”, based on the research of Major Watt Espy, Jr., is used to identify studies due to the dataset’s esteem and prolific usage. It is the largest known dataset of men’s and women’s executions in the United States since 1608 and has been of monumental significance to capital punishment research. The protocol established by the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses (PRISMA) is the methodology followed due to its conformity to scientific standards and acceptance in scholarly communities. The initial sampling frame involved 613 studies which were narrowed to 79 peer-reviewed journal articles that cited or utilized the Espy file. The empirical findings justify the contention that past and current studies, while interdisciplinary, require new voices and approaches to contribute to the study of capital punishment. Mainstream death penalty research does not generally incorporate critical theories including, for example, gender, intersectional, Black feminist, Queer, and other theories that focus less on quantitative data and more on how capital punishment is a reflection of institutional, historical, and social processes that are hierarchical and defined by power. The findings suggest that not only are executed women removed from many analyses, but so are inclusionary methodologies and theoretical approaches that could bolster the legitimacy of academic studies (inside academia as well as the judicial system) and our understanding of capital punishment in general. Full article
(This article belongs to the Section Gender Studies)
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9 pages, 1826 KB  
Case Report
Forensic Entomological Examinations for Animal Welfare Offices under Suboptimal Preservation Conditions
by Kristina Baumjohann and Mark Benecke
Forensic Sci. 2024, 4(3), 387-395; https://doi.org/10.3390/forensicsci4030023 - 1 Aug 2024
Cited by 2 | Viewed by 6151
Abstract
A female dog had allegedly been alive one day before its death. The veterinary office thought about accusing the dog’s owner for animal cruelty and commissioned forensic entomological expertise for the calculation of the time of insect colonization on the dog’s body. The [...] Read more.
A female dog had allegedly been alive one day before its death. The veterinary office thought about accusing the dog’s owner for animal cruelty and commissioned forensic entomological expertise for the calculation of the time of insect colonization on the dog’s body. The statement of the dog’s owner was proven false by us on the grounds of (a) the advanced state of decomposition and (b) the minimal developmental time of fly larvae found on the dog’s body. The darkening and deformation of the fly maggots as well as insufficient temperature data made case work trickier than usual. We worked through the case by creating forensic entomological temperature scenarios. The court used the entomological evidence and issued a penalty order. Full article
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25 pages, 8213 KB  
Article
Automatic Perception of Typical Abnormal Situations in Cage-Reared Ducks Using Computer Vision
by Shida Zhao, Zongchun Bai, Lianfei Huo, Guofeng Han, Enze Duan, Dongjun Gong and Liaoyuan Gao
Animals 2024, 14(15), 2192; https://doi.org/10.3390/ani14152192 - 27 Jul 2024
Cited by 5 | Viewed by 1880
Abstract
Overturning and death are common abnormalities in cage-reared ducks. To achieve timely and accurate detection, this study focused on 10-day-old cage-reared ducks, which are prone to these conditions, and established prior data on such situations. Using the original YOLOv8 as the base network, [...] Read more.
Overturning and death are common abnormalities in cage-reared ducks. To achieve timely and accurate detection, this study focused on 10-day-old cage-reared ducks, which are prone to these conditions, and established prior data on such situations. Using the original YOLOv8 as the base network, multiple GAM attention mechanisms were embedded into the feature fusion part (neck) to enhance the network’s focus on the abnormal regions in images of cage-reared ducks. Additionally, the Wise-IoU loss function replaced the CIoU loss function by employing a dynamic non-monotonic focusing mechanism to balance the data samples and mitigate excessive penalties from geometric parameters in the model. The image brightness was adjusted by factors of 0.85 and 1.25, and mainstream object-detection algorithms were adopted to test and compare the generalization and performance of the proposed method. Based on six key points around the head, beak, chest, tail, left foot, and right foot of cage-reared ducks, the body structure of the abnormal ducks was refined. Accurate estimation of the overturning and dead postures was achieved using the HRNet-48. The results demonstrated that the proposed method accurately recognized these states, achieving a mean Average Precision (mAP) value of 0.924, which was 1.65% higher than that of the original YOLOv8. The method effectively addressed the recognition interference caused by lighting differences, and exhibited an excellent generalization ability and comprehensive detection performance. Furthermore, the proposed abnormal cage-reared duck pose-estimation model achieved an Object Key point Similarity (OKS) value of 0.921, with a single-frame processing time of 0.528 s, accurately detecting multiple key points of the abnormal cage-reared duck bodies and generating correct posture expressions. Full article
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14 pages, 3213 KB  
Article
Qualitative/Quantitative Analysis of Alcohol and Licit/Illicit Drugs on Post-Mortem Biological Samples from Road Traffic Deaths
by Anna Carfora, Alessandro Feola, Raffaella Petrella, Giusy Ambrosio, Stefano Festinese, Ilaria Fracassi, Paolo Palermo, Martina Zampone and Carlo Pietro Campobasso
Separations 2023, 10(12), 589; https://doi.org/10.3390/separations10120589 - 1 Dec 2023
Cited by 1 | Viewed by 3568
Abstract
Alcohol and drug abuse is a major contributory factor of all road deaths in Europe. The aim of this study is to investigate the prevalence of alcohol and licit/illicit drug intake among victims of road accidents in Campania region (Italy). A retrospective analysis [...] Read more.
Alcohol and drug abuse is a major contributory factor of all road deaths in Europe. The aim of this study is to investigate the prevalence of alcohol and licit/illicit drug intake among victims of road accidents in Campania region (Italy). A retrospective analysis of road traffic deaths from 2013 to 2022 in Campania was performed. The toxicological results from fluid samples collected at autopsy were reviewed. In total, 228 road deaths occurred, mostly during nights and weekends. A total of 106 victims tested positive for alcohol and/or drugs, among which 39 (36.8%) tested positive for alcohol only, 27 (25.5%) for alcohol and drugs in association; and 40 (37.7%) for licit/illicit drugs only, either individually or in combination. Polydrug intake has been found in 21 victims, and nine in combination with alcohol. The most detected drugs were cocaine and Δ9THC, followed by benzodiazepines. Blood alcohol concentration (BAC) > 1.5 g/L was found in most alcohol positives, both alone and in association with drugs. Despite the penalties for driving under the influence of alcohol (DUI) and drugs (DUID), no decrease in the number of alcohol and/or drugs related fatal road accidents has been observed. DUI and/or DUID cases were approximately one third of the entire sample study. Full article
(This article belongs to the Section Forensic Science and Toxicology)
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15 pages, 980 KB  
Article
Identifying Predictors Associated with Risk of Death or Admission to Intensive Care Unit in Internal Medicine Patients with Sepsis: A Comparison of Statistical Models and Machine Learning Algorithms
by Antonio Mirijello, Andrea Fontana, Antonio Pio Greco, Alberto Tosoni, Angelo D’Agruma, Maria Labonia, Massimiliano Copetti, Pamela Piscitelli, Salvatore De Cosmo and on behalf of the Internal Medicine Sepsis Study Group
Antibiotics 2023, 12(5), 925; https://doi.org/10.3390/antibiotics12050925 - 18 May 2023
Cited by 8 | Viewed by 3790
Abstract
Background: Sepsis is a time-dependent disease: the early recognition of patients at risk for poor outcome is mandatory. Aim: To identify prognostic predictors of the risk of death or admission to intensive care units in a consecutive sample of septic patients, comparing different [...] Read more.
Background: Sepsis is a time-dependent disease: the early recognition of patients at risk for poor outcome is mandatory. Aim: To identify prognostic predictors of the risk of death or admission to intensive care units in a consecutive sample of septic patients, comparing different statistical models and machine learning algorithms. Methods: Retrospective study including 148 patients discharged from an Italian internal medicine unit with a diagnosis of sepsis/septic shock and microbiological identification. Results: Of the total, 37 (25.0%) patients reached the composite outcome. The sequential organ failure assessment (SOFA) score at admission (odds ratio (OR): 1.83; 95% confidence interval (CI): 1.41–2.39; p < 0.001), delta SOFA (OR: 1.64; 95% CI: 1.28–2.10; p < 0.001), and the alert, verbal, pain, unresponsive (AVPU) status (OR: 5.96; 95% CI: 2.13–16.67; p < 0.001) were identified through the multivariable logistic model as independent predictors of the composite outcome. The area under the receiver operating characteristic curve (AUC) was 0.894; 95% CI: 0.840–0.948. In addition, different statistical models and machine learning algorithms identified further predictive variables: delta quick-SOFA, delta-procalcitonin, mortality in emergency department sepsis, mean arterial pressure, and the Glasgow Coma Scale. The cross-validated multivariable logistic model with the least absolute shrinkage and selection operator (LASSO) penalty identified 5 predictors; and recursive partitioning and regression tree (RPART) identified 4 predictors with higher AUC (0.915 and 0.917, respectively); the random forest (RF) approach, including all evaluated variables, obtained the highest AUC (0.978). All models’ results were well calibrated. Conclusions: Although structurally different, each model identified similar predictive covariates. The classical multivariable logistic regression model was the most parsimonious and calibrated one, while RPART was the easiest to interpret clinically. Finally, LASSO and RF were the costliest in terms of number of variables identified. Full article
(This article belongs to the Special Issue Antibiotic Resistance and Antimicrobial Use in Elderly Patients)
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